Nanoparticle triggered autophagic cell death (Homo sapiens)

From WikiPathways

Description

Quality Tags

Ontology Terms

Bibliography

1. Li C, Liu H, Sun Y, Wang H, Guo F, Rao S, Deng J, Zhang Y, Miao Y, Guo C, Meng J, Chen X, Li L, Li D, Xu H, Li B, Jiang C; ''PAMAM nanoparticles promote acute lung injury by inducing autophagic cell death through the Akt-TSC2-mTOR signaling pathway.''; J Mol Cell Biol, 2009 PubMed Europe PMC Scholia
2. Liu HL, Zhang YL, Yang N, Zhang YX, Liu XQ, Li CG, Zhao Y, Wang YG, Zhang GG, Yang P, Guo F, Sun Y, Jiang CY; ''A functionalized single-walled carbon nanotube-induced autophagic cell death in human lung cells through Akt-TSC2-mTOR signaling.''; Cell Death Dis, 2011 PubMed Europe PMC Scholia
3. Andón FT, Fadeel B; ''Programmed Cell Death: Molecular Mechanisms and Implications for Safety Assessment of Nanomaterials.''; Acc Chem Res, 2012 PubMed Europe PMC Scholia
4. Khan MI, Mohammad A, Patil G, Naqvi SA, Chauhan LK, Ahmad I; ''Induction of ROS, mitochondrial damage and autophagy in lung epithelial cancer cells by iron oxide nanoparticles.''; Biomaterials, 2012 PubMed Europe PMC Scholia
5. Ma X, Wu Y, Jin S, Tian Y, Zhang X, Zhao Y, Yu L, Liang XJ; ''Gold nanoparticles induce autophagosome accumulation through size-dependent nanoparticle uptake and lysosome impairment.''; ACS Nano, 2011 PubMed Europe PMC Scholia

History

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Compare	Revision	Action	Time	User	Comment
	101755	view	14:00, 5 November 2018	Egonw	Added a missing identifier (for mTORC1)
	92315	view	08:49, 20 May 2017	Egonw	Ontology Term : 'nanomaterial response pathway' added !
	89322	view	22:07, 1 September 2016	Egonw	Fixed weird chars in references.
	89066	view	08:12, 19 August 2016	Fehrhart	Converted interaction to graphical line
	85994	view	09:53, 23 June 2016	Fehrhart	Connected some lines
	79822	view	07:41, 17 April 2015	Egonw	Marked a metabolite as @Type Metabolite.
	78509	view	10:29, 7 January 2015	MaintBot	added missing graphIds
	77899	view	14:40, 28 October 2014	Bart Smeets	Modified description
	77668	view	12:02, 5 October 2014	Egonw	Replaced 'Uniprot-SwissProt' by 'Uniprot-TrEMBL'.
	74142	view	10:19, 1 April 2014	Bart Smeets	Expanded description of nanoparticles in pathway, added corresponding literature references.
	73823	view	14:48, 25 February 2014	Bart Smeets	Added a few GeneIDs
	70990	view	06:25, 20 September 2013	Egonw	Another NPO term.
	70989	view	06:24, 20 September 2013	Egonw
	70984	view	21:15, 19 September 2013	Egonw	More gene IDs.
	70983	view	20:49, 19 September 2013	Egonw	Added a few gene IDs.
	65252	view	10:07, 6 June 2013	Egonw	Added the literature reference. Again.
	65251	view	10:00, 6 June 2013	Egonw	OK, the last corner.
	65154	view	15:25, 5 June 2013	Egonw	Another corner of the pathway.
	64853	view	06:57, 4 June 2013	Egonw	Added the literature reference.
	64735	view	11:56, 2 June 2013	Egonw	Ontology Term : 'autophagy pathway' added !
	64734	view	11:55, 2 June 2013	Egonw	Extended the pathway to match more content of the figure in the cited paper.
	64677	view	06:42, 1 June 2013	Andra	Ontology Term : 'cell death pathway' added !
	64676	view	06:39, 1 June 2013	Andra	Modified categories
	64624	view	20:47, 30 May 2013	Egonw	Added the literature reference.
	64623	view	20:45, 30 May 2013	Egonw	New pathway

External references

DataNodes

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Name	Type	Database reference	Comment
3MA	GeneProduct
AMPK	GeneProduct
Ambra1	GeneProduct
Atg14L	GeneProduct
BCL-2	GeneProduct
Beclin1	GeneProduct
Bif1	GeneProduct
IR
Insulin	Protein
Nanomaterial
PI3KCIII	GeneProduct
PI3k/AKT	GeneProduct
TCS-1	GeneProduct
TCS-2	GeneProduct
ULK1/2	GeneProduct
UVRAG	GeneProduct
mTORC1
p150	GeneProduct

Annotated Interactions

No annotated interactions