Nanoparticle triggered autophagic cell death (Homo sapiens)

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3PhagophoreAutophagosomeCELLSURVIVALAutophagosome formationVMP1Ambra1LC3-IIATG10InsulinTCS-1mTORC1PI3k/AKT3-MAPI3KCIIIULK1ATG9Carbon nanotubeAMPKIRBCL-2TCS-22Beclin1Atg14Lp150PI3KCIIIUVRAGBeclin1Bif1p150PI3KCIIILC3-IATG3ATG4ATG7ATG12ATG5ATG16LAu NPLysosomeimpairment5LysosomeAutophagolysosomeAUTOPHAGICCELL DEATHULK2PAMAMFeO NP14


Programmed cell death: autophagic cell death. Autophagy (self-eating) is a survival mechanism deployed by cells to cope with conditions of nutrient deprivation. However, unrestrained autophagy can result in genetically programmed cell death. Carbon nanotubes, PAMAMs, and iron oxide nanoparticles were reported to trigger autophagic cell death through the perturbation of the mTOR pathway, while gold nanoparticles may induce autophagy blockade through lysosomal impairment.

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  1. Li C, Liu H, Sun Y, Wang H, Guo F, Rao S, Deng J, Zhang Y, Miao Y, Guo C, Meng J, Chen X, Li L, Li D, Xu H, Li B, Jiang C; ''PAMAM nanoparticles promote acute lung injury by inducing autophagic cell death through the Akt-TSC2-mTOR signaling pathway.''; J Mol Cell Biol, 2009 PubMed Europe PMC Scholia
  2. Liu HL, Zhang YL, Yang N, Zhang YX, Liu XQ, Li CG, Zhao Y, Wang YG, Zhang GG, Yang P, Guo F, Sun Y, Jiang CY; ''A functionalized single-walled carbon nanotube-induced autophagic cell death in human lung cells through Akt-TSC2-mTOR signaling.''; Cell Death Dis, 2011 PubMed Europe PMC Scholia
  3. Andón FT, Fadeel B; ''Programmed Cell Death: Molecular Mechanisms and Implications for Safety Assessment of Nanomaterials.''; Acc Chem Res, 2012 PubMed Europe PMC Scholia
  4. Khan MI, Mohammad A, Patil G, Naqvi SA, Chauhan LK, Ahmad I; ''Induction of ROS, mitochondrial damage and autophagy in lung epithelial cancer cells by iron oxide nanoparticles.''; Biomaterials, 2012 PubMed Europe PMC Scholia
  5. Ma X, Wu Y, Jin S, Tian Y, Zhang X, Zhao Y, Yu L, Liang XJ; ''Gold nanoparticles induce autophagosome accumulation through size-dependent nanoparticle uptake and lysosome impairment.''; ACS Nano, 2011 PubMed Europe PMC Scholia


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101755view14:00, 5 November 2018EgonwAdded a missing identifier (for mTORC1)
92315view08:49, 20 May 2017EgonwOntology Term : 'nanomaterial response pathway' added !
89322view22:07, 1 September 2016EgonwFixed weird chars in references.
89066view08:12, 19 August 2016FehrhartConverted interaction to graphical line
85994view09:53, 23 June 2016FehrhartConnected some lines
79822view07:41, 17 April 2015EgonwMarked a metabolite as @Type Metabolite.
78509view10:29, 7 January 2015MaintBotadded missing graphIds
77899view14:40, 28 October 2014Bart SmeetsModified description
77668view12:02, 5 October 2014EgonwReplaced 'Uniprot-SwissProt' by 'Uniprot-TrEMBL'.
74142view10:19, 1 April 2014Bart SmeetsExpanded description of nanoparticles in pathway, added corresponding literature references.
73823view14:48, 25 February 2014Bart SmeetsAdded a few GeneIDs
70990view06:25, 20 September 2013EgonwAnother NPO term.
70989view06:24, 20 September 2013Egonw
70984view21:15, 19 September 2013EgonwMore gene IDs.
70983view20:49, 19 September 2013EgonwAdded a few gene IDs.
65252view10:07, 6 June 2013EgonwAdded the literature reference. Again.
65251view10:00, 6 June 2013EgonwOK, the last corner.
65154view15:25, 5 June 2013EgonwAnother corner of the pathway.
64853view06:57, 4 June 2013EgonwAdded the literature reference.
64735view11:56, 2 June 2013EgonwOntology Term : 'autophagy pathway' added !
64734view11:55, 2 June 2013EgonwExtended the pathway to match more content of the figure in the cited paper.
64677view06:42, 1 June 2013AndraOntology Term : 'cell death pathway' added !
64676view06:39, 1 June 2013AndraModified categories
64624view20:47, 30 May 2013EgonwAdded the literature reference.
64623view20:45, 30 May 2013EgonwNew pathway

External references


View all...
NameTypeDatabase referenceComment
3-MAMetabolite1673 (PubChem-compound)
ATG10GeneProductENSG00000152348 (Ensembl)
ATG12GeneProductENSG00000145782 (Ensembl)
ATG16LGeneProductENSG00000085978 (Ensembl)
ATG3GeneProductENSG00000144848 (Ensembl)
ATG4GeneProductENSG00000101844 (Ensembl)
ATG5GeneProductENSG00000057663 (Ensembl)
ATG7GeneProductENSG00000197548 (Ensembl)
ATG9GeneProductENSG00000181652 (Ensembl)
Ambra1GeneProductENSG00000110497 (Ensembl)
Atg14LGeneProductENSG00000126775 (Ensembl)
Au NPNPO_401 (NanoParticle Ontology)
BCL-2GeneProductENSG00000171791 (Ensembl)
Beclin1 GeneProductENSG00000126581 (Ensembl)
Bif1GeneProductENSG00000097033 (Ensembl)
Carbon nanotubeNPO_606 (NanoParticle Ontology)
FeO NPNPO_273 (NanoParticle Ontology)
IR GeneProductENSG00000171105 (Ensembl)
InsulinProteinP01308 (Uniprot-TrEMBL)
LC3-IGeneProductENSG00000101460 (Ensembl)
PAMAMNPO_965 (NanoParticle Ontology)
TCS-1GeneProductENSG00000165699 (Ensembl)
TCS-2GeneProductENSG00000103197 (Ensembl)
ULK1GeneProductENSG00000177169 (Ensembl)
ULK2GeneProductENSG00000083290 (Ensembl)
UVRAGGeneProductENSG00000198382 (Ensembl)
VMP1GeneProductENSG00000062716 (Ensembl)
mTORC1ComplexQ6718498 (Wikidata)
p150 GeneProductENSG00000167670 (Ensembl)

Annotated Interactions

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