Nanoparticle triggered autophagic cell death (Homo sapiens)

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Revision as of 10:07, 6 June 2013 by Egonw (Talk | contribs)
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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Ambra1Beclin1Atg14Lp150PI3KCIIIPhagophoreAutophagosome formationAutophagosomeCELLSURVIVALIRInsulinPI3k/AKTNanomaterialAMPKmTORC1ULK1/2PI3KCIIIBCL-23MALC3-IIATG10TCS-1TCS-2ATG9VMP1UVRAGBeclin1Bif1p150PI3KCIIILC3-IATG3ATG4ATG7ATG12ATG5ATG16LNanomaterialLysosomeimpairmentLysosomeAutophagolysosomeAUTOPHAGICCELL DEATHName: Nanoparticle triggered autophagic cell deathOrganism: Homo sapiens


Description

No description

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Quality Tags

Image:Curated.pngReview changes for Approved
Image:MissingXref.pngAnnotate nodes
Image:Wplogo_31.pngCommunity: Adverse Outcome Pathways

Ontology Terms

Bibliography

  1. Li C, Liu H, Sun Y, Wang H, Guo F, Rao S, Deng J, Zhang Y, Miao Y, Guo C, Meng J, Chen X, Li L, Li D, Xu H, Li B, Jiang C; ''PAMAM nanoparticles promote acute lung injury by inducing autophagic cell death through the Akt-TSC2-mTOR signaling pathway.''; J Mol Cell Biol, 2009 PubMed Europe PMC Scholia
  2. Liu HL, Zhang YL, Yang N, Zhang YX, Liu XQ, Li CG, Zhao Y, Wang YG, Zhang GG, Yang P, Guo F, Sun Y, Jiang CY; ''A functionalized single-walled carbon nanotube-induced autophagic cell death in human lung cells through Akt-TSC2-mTOR signaling.''; Cell Death Dis, 2011 PubMed Europe PMC Scholia
  3. Andón FT, Fadeel B; ''Programmed Cell Death: Molecular Mechanisms and Implications for Safety Assessment of Nanomaterials.''; Acc Chem Res, 2012 PubMed Europe PMC Scholia
  4. Khan MI, Mohammad A, Patil G, Naqvi SA, Chauhan LK, Ahmad I; ''Induction of ROS, mitochondrial damage and autophagy in lung epithelial cancer cells by iron oxide nanoparticles.''; Biomaterials, 2012 PubMed Europe PMC Scholia
  5. Ma X, Wu Y, Jin S, Tian Y, Zhang X, Zhao Y, Yu L, Liang XJ; ''Gold nanoparticles induce autophagosome accumulation through size-dependent nanoparticle uptake and lysosome impairment.''; ACS Nano, 2011 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
101755
Approved
AOP
view14:00, 5 November 2018EgonwAdded a missing identifier (for mTORC1)
92315view08:49, 20 May 2017EgonwOntology Term : 'nanomaterial response pathway' added !
89322view22:07, 1 September 2016EgonwFixed weird chars in references.
89066view08:12, 19 August 2016FehrhartConverted interaction to graphical line
85994view09:53, 23 June 2016FehrhartConnected some lines
79822view07:41, 17 April 2015EgonwMarked a metabolite as @Type Metabolite.
78509view10:29, 7 January 2015MaintBotadded missing graphIds
77899view14:40, 28 October 2014Bart SmeetsModified description
77668view12:02, 5 October 2014EgonwReplaced 'Uniprot-SwissProt' by 'Uniprot-TrEMBL'.
74142view10:19, 1 April 2014Bart SmeetsExpanded description of nanoparticles in pathway, added corresponding literature references.
73823view14:48, 25 February 2014Bart SmeetsAdded a few GeneIDs
70990view06:25, 20 September 2013EgonwAnother NPO term.
70989view06:24, 20 September 2013Egonw
70984view21:15, 19 September 2013EgonwMore gene IDs.
70983view20:49, 19 September 2013EgonwAdded a few gene IDs.
65252view10:07, 6 June 2013EgonwAdded the literature reference. Again.
65251view10:00, 6 June 2013EgonwOK, the last corner.
65154view15:25, 5 June 2013EgonwAnother corner of the pathway.
64853view06:57, 4 June 2013EgonwAdded the literature reference.
64735view11:56, 2 June 2013EgonwOntology Term : 'autophagy pathway' added !
64734view11:55, 2 June 2013EgonwExtended the pathway to match more content of the figure in the cited paper.
64677view06:42, 1 June 2013AndraOntology Term : 'cell death pathway' added !
64676view06:39, 1 June 2013AndraModified categories
64624view20:47, 30 May 2013EgonwAdded the literature reference.
64623view20:45, 30 May 2013EgonwNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
3MAGeneProduct
AMPKGeneProduct
ATG10GeneProduct
ATG12GeneProduct
ATG16LGeneProduct
ATG3GeneProduct
ATG4GeneProduct
ATG5GeneProduct
ATG7GeneProduct
ATG9GeneProduct
Ambra1GeneProduct
Atg14LGeneProduct
BCL-2GeneProduct
Beclin1 GeneProduct
Bif1GeneProduct
IR
InsulinProtein
LC3-IGeneProduct
LC3-IIGeneProduct
Nanomaterial
PI3KCIIIGeneProduct
PI3k/AKTGeneProduct
TCS-1GeneProduct
TCS-2GeneProduct
ULK1/2GeneProduct
UVRAGGeneProduct
VMP1GeneProduct
mTORC1
p150 GeneProduct

Annotated Interactions

No annotated interactions

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