Histidine, purine, and pyrimidine superpathway (Saccharomyces cerevisiae)
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NH3
5âÂÂ-phosphoribosyl-4-(N-
H2O
H2O
D-erythro-imidazole-glycerol-phosphate
imidazole acetol-phosphate
2-oxoglutarate
H2O
5-phosphoribosyl-n-formylglycineamidine
UTP
phosphoribosyl-AMP
acceptor
H2O
H+
phosphoribosylformiminoAICAR-phosphate
NAD
carbamoyl-phosphate
AMP
5âÂÂ-phosphoribosyl-N-formylglycineamide
H2O
HCO3
H2O
H2O
5-phosphoribosylamine
phosphoribosyl-carboxy-aminoimidazole
H+
fumerate
H2O
dihydroorotate
oxidized thioredoxin
orotate
orotidine-5âÂÂ-phosphate
CTP
NAD
H2O
H2O
AMP
THF
histidinal
CO2
carbamoyl-L-aspartate
histidinol
AMP
H+
5âÂÂ-phosphoribosyl-5-aminoimidazole
H2O
reduced flavodoxin
H2O
NAD
reduced thioredoxin
sucinocarboxamide)-5-aminoimidazole
H2O
L-aspartate
5-phospho-ribosyl-glycineamide
UMP
phosphoribosyl-ATP
CO2
UDP
reduced acceptor
phosphoribosyl-formamido-carboxamide
IMP
deoxy-GTP
phosphoribulosylformimino-AICAR-P
H2O
H2O
H2O
oxidized flavodoxin
THF
L-aspartate
phosphate
L-glutamine
L-histidine
ATP
PRS4
URA2
10-formyl-THF
phosphate
pyrophosphate
PRS1
L-histidinol-phosphate
xanthosine-5-phosphate
dGDP
ATP
HIS5
ADE5,7
ATP
GDP
HIS2
PRS5
HIS4
URA2
URA10
ATP
URA5
L-glutamate
ADP
NADH
GUK1
NADH
HIS6
2 ATP
PRS2
ADP
NADH
YNK1
HIS3
L-glutamate
ATP
ADE4
URA8
ATP
GUA1
HIS4
ADE1
ADP
GTP
ATP
pyrophosphate
ADP
URA1
pyrophosphate
IMD4
phosphate
GMP
pyrophosphate
URA7
L-glutamine
phosphate
URA4
L-glutamate
ATP
L-glutamate
ATP
HIS1
ribose-5-phosphate
ADP
YNK1
ATP
phosphate
ADE5,7
URA6
HIS4
RNR4
2 ADP
L-glutamine
L-glutamine
L-glutamine
phosphate
L-glutamine
pyrophosphate
IMD2
ADP
ADE8
ADE17
ADP
ADP
ADP
10-formyl-THF
ADE2
phosphate
RNR2
ATP
ATP
RNR1
phosphate
L-glycine
PRS3
ATP
L-glutamate
HIS4
PRPP
L-glutamate
ATP
ADE6
RNR3
ADE16
IMD3
phosphate
ADE16
ATP
AICAR
ADP
CDP
ADE13
URA3
ADP
L-glutamate
phosphate
ADP
ATP
ADE17
Description
No description
Comments
GenMAPP remarks
Based on
http://pathway.yeastgenome.org/biocyc/
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Quality Tags
Ontology Terms
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Bibliography
''Histidine, purine, and pyrimidine superpathway''; YeastPathways,
History
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Compare
Revision
Action
Time
User
Comment
135544
view
20:00, 23 September 2024
Khanspers
Modified description
135448
view
21:58, 5 September 2024
Khanspers
Ontology Term : 'classic metabolic pathway' added !
135447
view
21:58, 5 September 2024
Khanspers
removed GenMAPP comments
135446
view
21:57, 5 September 2024
Khanspers
135445
view
21:56, 5 September 2024
Khanspers
lit ref
135314
view
00:05, 17 August 2024
Khanspers
interactions
122754
view
05:17, 10 May 2022
Egonw
Added identifiers to water nodes
117345
view
11:53, 20 May 2021
Eweitz
Modified title
107259
view
14:35, 17 September 2019
MaintBot
ChEBI identifier normalization
94664
view
13:18, 4 October 2017
DeSl
Changed ribose-5-P label to D-ribose-5-P
94663
view
13:17, 4 October 2017
DeSl
Connected all lines, changed all textlabels to metabolite nodes, connected all genes to the lines.
93079
view
09:22, 28 July 2017
Elisa
Fixed some of the unconnected interactions (left side of the pathway).
93011
view
14:46, 24 July 2017
DeSl
Changed wrong CAS number (salt) for correct ChEBI ID
85638
view
16:11, 4 June 2016
Egonw
Fixed the CAS number.
71897
view
10:35, 22 October 2013
Mkutmon
changed AICAR from Unknown to Metabolite
70270
view
21:50, 15 July 2013
MaintBot
updated to 2013 schema
69872
view
18:00, 11 July 2013
Egonw
Marked a few DataNodes with CAS registry numbers as metabolites.
67670
view
11:47, 26 June 2013
Ddigles
Ontology Term : 'nucleotide metabolic pathway' added !
41803
view
04:48, 2 March 2011
MaintBot
Removed redundant pathway information and comments
21558
view
11:32, 14 November 2008
MaintBot
[[Pathway:Saccharomyces cerevisiae:Superpathway of Histidine Purine and Pyrimidine Biosynthesis]] moved to [[Pathway:WP416]]: Moved to stable identifier
12861
view
08:06, 17 May 2008
MaintBot
automated metabolite conversion
8948
view
14:13, 7 January 2008
MaintBot
Added to category $category
8946
view
14:13, 7 January 2008
M.Braymer
Uploaded new pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
10-formyl-THF
2800-34-2 (CAS)
2 ADP
58-64-0 (CAS)
2 ATP
1927-31-7 (CAS)
ADE13
GeneProduct
S000004351 (SGD)
ADE16
GeneProduct
S000004018 (SGD)
ADE17
GeneProduct
S000004727 (SGD)
ADE1
GeneProduct
S000000070 (SGD)
ADE2
GeneProduct
S000005654 (SGD)
ADE4
GeneProduct
S000004915 (SGD)
ADE5,7
GeneProduct
S000003203 (SGD)
ADE6
GeneProduct
S000003293 (SGD)
ADE8
GeneProduct
S000002816 (SGD)
ADP
58-64-0 (CAS)
AICAR
3031-94-5 (CAS)
ATP
1927-31-7 (CAS)
CDP
63-38-7 (CAS)
GDP
146-91-8 (CAS)
GMP
85-32-5 (CAS)
GTP
2564-35-4 (CAS)
GUA1
GeneProduct
S000004830 (SGD)
GUK1
GeneProduct
S000001550 (SGD)
HIS1
GeneProduct
S000000857 (SGD)
HIS2
GeneProduct
S000001921 (SGD)
HIS3
GeneProduct
S000005728 (SGD)
HIS4
GeneProduct
S000000535 (SGD)
HIS5
GeneProduct
S000001378 (SGD)
HIS6
GeneProduct
S000001282 (SGD)
IMD2
GeneProduct
S000001259 (SGD)
IMD3
GeneProduct
S000004424 (SGD)
IMD4
GeneProduct
S000004520 (SGD)
L-glutamate
56-86-0 (CAS)
L-glutamine
56-85-9 (CAS)
L-glycine
56-40-6 (CAS)
L-histidine
71-001 (CAS)
L-histidinol-phosphate
25679-93-0 (CAS)
NADH
53-84-9 (CAS)
PRPP
97-55-2 (CAS)
PRS1
GeneProduct
S000001664 (SGD)
PRS2
GeneProduct
S000000901 (SGD)
PRS3
GeneProduct
S000001003 (SGD)
PRS4
GeneProduct
S000000164 (SGD)
PRS5
GeneProduct
S000005422 (SGD)
RNR1
GeneProduct
S000000872 (SGD)
RNR2
GeneProduct
S000003563 (SGD)
RNR3
GeneProduct
S000001328 (SGD)
RNR4
GeneProduct
S000003412 (SGD)
URA10
GeneProduct
S000004884 (SGD)
URA1
GeneProduct
S000001699 (SGD)
URA2
GeneProduct
S000003666 (SGD)
URA3
GeneProduct
S000000747 (SGD)
URA4
GeneProduct
S000004412 (SGD)
URA5
GeneProduct
S000004574 (SGD)
URA6
GeneProduct
S000001507 (SGD)
URA7
GeneProduct
S000000135 (SGD)
URA8
GeneProduct
S000003864 (SGD)
YNK1
GeneProduct
S000001550 (SGD)
dGDP
102783-74-4 (CAS)
phosphate
14265-44-2 (CAS)
pyrophosphate
2466-09-3 (CAS)
ribose-5-phosphate
3615-55-2 (CAS)
xanthosine-5-phosphate
523-98-8 (CAS)
Annotated Interactions
No annotated interactions
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