TNF-alpha NF-kB signaling pathway (Rattus norvegicus)

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ENCY ->NUERActivationMethylationSumoylation(Protein-protein interaction)AcetylationPhosphorylationMTDesumoylationControlDeacetylationCY ->NUCytoplasmInhibitionEndoplasmic reticulumMolecular associationReceptorGOPalmitoylationDephosphorylationCYDeubiquitinationGolgi apparatusPlasma membraneLigandPMNucleusDemethylationAutophosphorylationEnzyme complexMolecule in the pathwayUbiquitinationNUMitochondrionCY ->NUECCY ->NURecruitmentProteolytic cleavageDTranslocationReaction through unknown mechanisms/moleculesAccession Number: NetPath 9; cellmap:9EndosomeProteins in a complex interactionExtracellularGlycosylationCY ->NURELBNfkb1Usp11Tnfrsf8Rps11LOC685179Map2k5G3bp2TRAF5TifaRelaMark2GeneNfkbiaPolr1aRipk1CraddMcm7NALP4PrkacaNfkbibKTN1TnfUBCH5CBtrcHIST3H3RelaTnfrsf1bAlplFkbp5TraipUbe2d2ChukYWHAQPtk2PapolaGtf2iTnfIkbkgPebp1Tnip1Psmd6Birc2Nfkb1Smarce1RGD1561988Bag4Kpna3Akt1Tnfrsf1bTraddLrpprcFancd2Hspb1TnfNfkbizMap3k2Traf3RelaNr2c2LOC681193Pkn1Birc3Casp8TnfDpf2FaddTraf2Mtif2Traf4Csnk2a2SKP1AUbe2iRipk2RELBTBKBP1Nr2c2RPS13Casp8ap2YwhabRelSUMO1Gene 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


Description

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Comments

GenMAPP notes 
NetPath 9 ; cellmap:9 - TNF-alpha/NF-kB Signaling Pathway This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP231(r28972) with a 85% conversion rate.

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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
117025view11:52, 16 May 2021EweitzModified title
69441view19:05, 8 July 2013MaintBotUpdated to 2013 gpml schema
67702view11:51, 26 June 2013DdiglesOntology Term : 'tumor necrosis factor mediated signaling pathway' added !
41766view02:41, 2 March 2011MaintBotRemoved redundant pathway information and comments
34134view19:31, 9 December 2009MaintBotAutomatic update of empty xrefs
32438view17:16, 15 August 2009MaintBotFixed text labels
32108view13:47, 14 August 2009MaintBotFixed group labels
31458view21:14, 13 August 2009MaintBotFixed text labels
30990view00:56, 30 July 2009MaintBotConverted from Homo sapiens
21642view11:32, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:TNF-alpha-NF-kB NetPath 9]] moved to [[Pathway:WP457]]: Moved to stable identifier
8450view13:46, 7 January 2008MaintBot[[Pathway:Rat:TNF-alpha-NF-kB NetPath 9]] moved to [[Pathway:Rattus norvegicus:TNF-alpha-NF-kB NetPath 9]]: Renaming species
7841view16:22, 18 December 2007MaintBotfixed category names
7309view12:42, 4 November 2007MaintBotAdded categories to GPML
6603view22:20, 22 May 2007A.Pandeygpml file for [[Rat:TNF-alpha-NF-kB_NetPath_9]]

External references

DataNodes

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NameTypeDatabase referenceComment
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Zfand5GeneProduct293960 (Entrez Gene)

Annotated Interactions

No annotated interactions
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