Oxidation by cytochrome P450 (Equus caballus)

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1Cytochrome P450 genesactivated O2NAD+CYP4F2dia1CYP2G1Pcyp4NADHcyp11b2cyp4cyp51cyp24a1lzgc:63920H2Ocyp1aFe2+CYP19A1CYP2F1CYP2C18cyp11b2CYP2C9CYP4F2cyb5r3CYP4F2SubstrateCYP4F2cyb5acyp26b1cyp4CYP2C19cyb5bCYPcyp1aCYP2S1PORCYP2B6CYP27B1cyp26c1CYP2W1zgc:174342Fe3+CYP2D6si:dkey-69h9.1CYPcyp17a1zgc:112177cyp2u1Substrate-OHcyb5aCYP2E1cyp11a1zgc:63986SubstrateSubstrateCYP3A4cyb5aSubstrateCYP27A1NADP+CYP2A7A9JRH5_DANREcyb5bCYP4F2cyp27c1Fe2+CYP3A7LOC570455CYP3A5CYPcyp1b1SubstrateCYPO2CYPCYP2A13zgc:153291cyp26a1CYP3A43O2CYP46A1cyb5bFe3+cyp4cyp4CYP2A6Fe3+NADPHcyp4v2LOC793249Fe3+CYP2C8CYP2J2Fe2+cyp51CYP4F2Fe2+


Description

Oxidation of a substrate by Cytochrome P450. Adapted from Niesink et al., Chapter 3, p. 47-48.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP43(r29608) with a 56% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Niesink, R.J.M, Vries, de, J., Hollinger, M.A.; ''Toxicology; Principles and Applications''; , 1996

History

View all...
CompareRevisionActionTimeUserComment
118190view10:51, 25 May 2021EweitzModified title
107103view14:18, 17 September 2019MaintBotChEBI identifier normalization
88272view14:35, 1 August 2016FehrhartOntology Term : 'hepatocyte' added !
88271view14:35, 1 August 2016FehrhartOntology Term : 'phase I biotransformation pathway via cytochrome P450' added !
88270view14:34, 1 August 2016FehrhartOntology Term : 'xenobiotics biodegradation pathway' added !
80418view10:13, 20 June 2015EgonwWater is not a gene product.
79836view07:41, 18 April 2015EgonwFixed metabolite identifiers.
79407view20:38, 21 March 2015Khanspersupdate schema
79406view20:37, 21 March 2015KhanspersModified title
79405view20:36, 21 March 2015KhanspersReverted to version '00:33, 21 February 2013' by Khanspers
68742view22:53, 6 July 2013MaintBotUpdated to 2013 gpml schema
58875view00:33, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
40915view22:41, 1 March 2011MaintBotRemoved redundant pathway information and comments
31826view12:25, 14 August 2009MaintBotFixed group labels
30788view23:37, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
A9JRH5_DANREGeneProductENSDARG00000056587 (Ensembl)
CYPGeneProduct
CYP19A1GeneProduct
CYP27A1GeneProduct
CYP27B1GeneProductENSDARG00000045015 (Ensembl)
CYP2A13GeneProduct
CYP2A6GeneProduct
CYP2A7GeneProduct
CYP2B6GeneProduct
CYP2C18GeneProduct
CYP2C19GeneProduct
CYP2C8GeneProduct
CYP2C9GeneProduct
CYP2D6GeneProduct
CYP2E1GeneProduct
CYP2F1GeneProduct
CYP2G1PGeneProduct
CYP2J2GeneProduct
CYP2S1GeneProduct
CYP2W1GeneProduct
CYP3A4GeneProduct
CYP3A43GeneProduct
CYP3A5GeneProduct
CYP3A7GeneProduct
CYP46A1GeneProduct553543 (Entrez Gene)
CYP4F2GeneProductENSDARG00000053530 (Ensembl)
Fe2+Metabolite29033 (ChEBI)
Fe3+Metabolite29034 (ChEBI)
H2OMetabolite962 (Pubchem-compound)
LOC570455GeneProductENSDARG00000008858 (Ensembl)
LOC793249GeneProductENSDARG00000037550 (Ensembl)
NAD+Metabolite15846 (ChEBI)
NADHMetabolite16908 (ChEBI)
NADP+Metabolite18009 (ChEBI)
NADPHMetabolite16474 (ChEBI)
O2MetaboliteHMDB01377 (HMDB)
PORGeneProduct568202 (Entrez Gene)
SubstrateGeneProduct
Substrate-OHGeneProduct
activated O2Metabolite
cyb5aGeneProductENSDARG00000055643 (Ensembl)
cyb5bGeneProductENSDARG00000053954 (Ensembl)
cyb5r3GeneProductENSDARG00000005891 (Ensembl)
cyp11a1GeneProductENSDARG00000002347 (Ensembl)
cyp11b2GeneProductENSDARG00000042014 (Ensembl)
cyp17a1GeneProductENSDARG00000033566 (Ensembl)
cyp1aGeneProductENSDARG00000026039 (Ensembl)
cyp1b1GeneProductENSDARG00000068934 (Ensembl)
cyp24a1lGeneProductENSDARG00000070420 (Ensembl)
cyp26a1GeneProductENSDARG00000033999 (Ensembl)
cyp26b1GeneProductENSDARG00000077121 (Ensembl)
cyp26c1GeneProductENSDARG00000056029 (Ensembl)
cyp27c1GeneProductENSDARG00000058439 (Ensembl)
cyp2u1GeneProductENSDARG00000026548 (Ensembl)
cyp4GeneProductENSDARG00000004964 (Ensembl)
cyp4v2GeneProductENSDARG00000062132 (Ensembl)
cyp51GeneProductENSDARG00000042641 (Ensembl)
dia1GeneProductENSDARG00000018966 (Ensembl)
si:dkey-69h9.1GeneProductENSDARG00000017982 (Ensembl)
zgc:112177GeneProductENSDARG00000020898 (Ensembl)
zgc:153291GeneProductENSDARG00000051925 (Ensembl)
zgc:174342GeneProductENSDARG00000053068 (Ensembl)
zgc:63920GeneProductENSDARG00000069018 (Ensembl)
zgc:63986GeneProductENSDARG00000006040 (Ensembl)

Annotated Interactions

No annotated interactions
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