EGFR1 signaling pathway (Gallus gallus)

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1NUNUEndoplasmic reticulumCYPhosphorylationAccession Number : NetPath 4; cellmap:4DPMPMGlycosylationCYCYCYNUMAMAAcetylationMitochondrionNUCYDENECPMCYReaction through unknown mechanisms/moleculesMolecule in the pathwayDeubiquitinationCYAutophosphorylationCYNUMACYCYPMMAInhibitionCYDDephosphorylationGOCYPMPlasma membraneSumoylationControlCYPMRecruitmentCYCYDemethylationPalmitoylationPMNUMolecular associationGene SymbolPMPMNUTranslocationMAMAPMMAPMCYCYPMCYGolgi apparatusNUCYNUERMANUNUMA(Protein-protein interaction)PMAutodephosphorylationPMCYEndosomePMPMNucleusMTCYNUMAProteolytic cleavageMAMAMACYNUMANUCYMethylationUbiquitinationCYPMDesumoylationCYCYCYProteins in a complex interactionNUCYPMDeacetylationActivationENMAMACytoplasmMACYNUNUENCYMAEnzyme complexCYReceptorPMMAPMExtracellularNUNUCYCYCYCYMANUMAPMPMLigandRPS6KA3MAP2K2MAPK1APPL2EGFREPS15L1RCJMB04_17i9VAV2MAP3K3SRCCAV2HDAC1TGIF1SH2D3CPTPRRSTAT3CRKRGS16SHOC2ERRFI1MAPK8CRKLEGFRSPRY2RCJMB04_8f10APPL1ELF3RCJMB04_13d16STAT5ACEBPBRBBP7EPN1SIN3AAKT1MAPK7EPPK1GAB1RALBMAPK14EEF1A1MAP3K2CAV1STAT5BRPS6KA3MYCPLD1APPL1VAV1FOXO1ASH3BGRLAPPL1TNIP1EPS8KRT17PIK3CGPRKCZSOS1YWHABAPPL2PLD1SOCS3CBLPLCG1RCJMB04_5a10EGFRMAP2K7RALGDSPXNPLD2PRKCGRCJMB04_16p24KRASVAV3WASLSTAT5ADUSP1SMAD2RFXANKMCF2JUNDDNM1MAPK1HIST3H3PLSCR1FOSUSP6NLPIK3CAMAP3K1INPPL1PLCG2RAC1FOXO1APIK3CBCSKSH3GL2RIPK1HTTSP1RPS6KA5RASA1REPS2CEBPANCK1JAK2MAP3K4RAF1ZNF259MAP2K1GAB2EGFSTAT3GRB2MAPK3RCJMB04_1d5KLF11KRT18RCJMB04_5a10PTK2BPLCG1GRB14PTPN6PIK3R2DOK2EGFHIP1SPRY2CREB1CBLBRAB5ASH3KBP1MAP2K1GRB7RCJMB04_4o17PRKCBPLEC1PIK3R1ARF4ITCHSTAT2DDEF1SMAD2NRASGRB10SNRPD2ELK1PIK3R3SHC1KRT8ARF4RPS6KA2KRT7PITPNARAF1NDUFA13GAB1BCAR1EEF1A1PTPN11PTPN12HAT1SNCAPAK1MAP3K2EGFRPTK6ARF4EGFPRKAR1AARAFATF1SOCS1PTPN5PTPN6RCJMB04_36h7RCJMB04_17i9SMAD3SH3GL3SH3GL2MAP3K14MTA2CDC42AP2A1PIK3CDSTXBP1PLCG2WNK1BCAR1TNK2CAMK2AELK4CEACAM1SOS2SMAD3CBLCRCJMB04_1d5PKN2RPS6KA1CASP9SH2D3CRCJMB04_12k21RCJMB04_25c5DUSP1REPS1RCJMB04_17i9GIT1HRASELF3SHC1STAT3PEBP1STAT2JUNJAK1PIK3C2BZNF259STXBP1GJA1RCJMB04_21j12


Description

The androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among others, dimerize and bind to DNA. Its ligands include testosterone, dehydroepiandrosterone and androstenedione. Stimulation of the receptor activates the SMAD signaling module. Source: http://www.netpath.org/pathways?path_id=NetPath_4

Comments

GenMAPP notes 
NetPath 4; cellmap:4 - EGFR1 Signaling Pathway.This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP437(r21600) with a 77% conversion rate.

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Bibliography

  1. Hornberg JJ, Binder B, Bruggeman FJ, Schoeberl B, Heinrich R, Westerhoff HV; ''Control of MAPK signalling: from complexity to what really matters.''; Oncogene, 2005 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117193view10:32, 18 May 2021EweitzModified title
68850view17:19, 8 July 2013MaintBotUpdated to 2013 gpml schema
67179view10:17, 26 June 2013Christine ChichesterOntology Term : 'epidermal growth factor/neuregulin signaling pathway' added !
40988view22:55, 1 March 2011MaintBotRemoved redundant pathway information and comments
35719view23:29, 12 February 2010AlexanderPico
35437view11:34, 12 February 2010MichielAdded ref
33910view18:03, 9 December 2009MaintBotAutomatic update of empty xrefs
30321view20:43, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AKT1GeneProduct395928 (Entrez Gene)
AP2A1GeneProduct
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APPL2GeneProduct418075 (Entrez Gene)
ARAFGeneProduct
ARF4GeneProduct769725 (Entrez Gene)
ATF1GeneProduct426873 (Entrez Gene)
BCAR1GeneProduct415691 (Entrez Gene)
CAMK2AGeneProduct374175 (Entrez Gene)
CASP9GeneProduct426970 (Entrez Gene)
CAV1GeneProduct373996 (Entrez Gene)
CAV2GeneProduct417772 (Entrez Gene)
CBLGeneProduct374038 (Entrez Gene)
CBLBGeneProduct418406 (Entrez Gene)
CBLCGeneProduct
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CEACAM1GeneProduct
CEBPAGeneProduct427549 (Entrez Gene)
CEBPBGeneProduct396185 (Entrez Gene)
CREB1GeneProduct395099 (Entrez Gene)
CRKGeneProduct417553 (Entrez Gene)
CRKLGeneProduct416939 (Entrez Gene)
CSKGeneProduct396396 (Entrez Gene)
DDEF1GeneProduct428385 (Entrez Gene)
DNM1GeneProduct417217 (Entrez Gene)
DOK2GeneProduct
DUSP1GeneProduct374192 (Entrez Gene)
EEF1A1GeneProduct373963 (Entrez Gene)
EGFGeneProduct408035 (Entrez Gene)
EGFRGeneProduct396494 (Entrez Gene)
ELF3GeneProduct421177 (Entrez Gene)
ELK1GeneProduct
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EPN1GeneProduct
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EPS15L1GeneProduct420147 (Entrez Gene)
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ERRFI1GeneProduct419364 (Entrez Gene)
FOSGeneProduct396512 (Entrez Gene)
FOXO1AGeneProduct374231 (Entrez Gene)
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GAB2GeneProduct419027 (Entrez Gene)
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GJA1GeneProduct395278 (Entrez Gene)
GRB10GeneProduct420948 (Entrez Gene)
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GRB7GeneProduct
HAT1GeneProduct374037 (Entrez Gene)
HDAC1GeneProduct373961 (Entrez Gene)
HIP1GeneProduct770683 (Entrez Gene)
HIST3H3GeneProduct
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INPPL1GeneProduct428692 (Entrez Gene)
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JAK1GeneProduct395681 (Entrez Gene)
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JUNDGeneProduct
KLF11GeneProduct421934 (Entrez Gene)
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KRT17GeneProduct
KRT18GeneProduct
KRT7GeneProduct
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PITPNAGeneProduct
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PLCG1GeneProduct
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PLEC1GeneProduct
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PRKCBGeneProduct416567 (Entrez Gene)
PRKCGGeneProduct
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PTK2BGeneProduct421998 (Entrez Gene)
PTK6GeneProduct
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PTPRRGeneProduct771985 (Entrez Gene)
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RAB5AGeneProduct420649 (Entrez Gene)
RAC1GeneProduct395871 (Entrez Gene)
RAF1GeneProduct396245 (Entrez Gene)
RALBGeneProduct424237 (Entrez Gene)
RALGDSGeneProduct427758 (Entrez Gene)
RASA1GeneProduct427327 (Entrez Gene)
RBBP7GeneProduct395390 (Entrez Gene)
RCJMB04_12k21GeneProduct423302 (Entrez Gene)
RCJMB04_13d16GeneProduct418727 (Entrez Gene)
RCJMB04_16p24GeneProduct424991 (Entrez Gene)
RCJMB04_17i9GeneProduct424044 (Entrez Gene)
RCJMB04_1d5GeneProduct424633 (Entrez Gene)
RCJMB04_21j12GeneProduct428852 (Entrez Gene)
RCJMB04_25c5GeneProduct420489 (Entrez Gene)
RCJMB04_36h7GeneProduct415557 (Entrez Gene)
RCJMB04_4o17GeneProduct429466 (Entrez Gene)
RCJMB04_5a10GeneProduct417430 (Entrez Gene)
RCJMB04_8f10GeneProduct416496 (Entrez Gene)
REPS1GeneProduct421678 (Entrez Gene)
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RPS6KA1GeneProduct386579 (Entrez Gene)
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RPS6KA3GeneProduct418605 (Entrez Gene)
RPS6KA5GeneProduct423408 (Entrez Gene)
SH2D3CGeneProduct417225 (Entrez Gene)
SH3BGRLGeneProduct422277 (Entrez Gene)
SH3GL2GeneProduct395203 (Entrez Gene)
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SH3KBP1GeneProduct418608 (Entrez Gene)
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SHOC2GeneProduct423894 (Entrez Gene)
SIN3AGeneProduct415307 (Entrez Gene)
SMAD2GeneProduct395247 (Entrez Gene)
SMAD3GeneProduct395132 (Entrez Gene)
SNCAGeneProduct395393 (Entrez Gene)
SNRPD2GeneProduct
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STAT2GeneProduct
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STAT5AGeneProduct
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TNK2GeneProduct431014 (Entrez Gene)
USP6NLGeneProduct423110 (Entrez Gene)
VAV1GeneProduct
VAV2GeneProduct373938 (Entrez Gene)
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WASLGeneProduct417750 (Entrez Gene)
WNK1GeneProduct427925 (Entrez Gene)
YWHABGeneProduct419190 (Entrez Gene)
ZNF259GeneProduct428256 (Entrez Gene)

Annotated Interactions

No annotated interactions
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