IL-1 signaling pathway (Mus musculus)

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DeubiquitinationControlDDesumoylationActivation(Protein-protein interaction)PMDCY->EXPM -> CYENProteolytic cleavageLigandReceptorDDephosphorylationMolecule in the pathwayPM -> CYDDeacetylationPlasma membraneDAccession Number: NetPath 13RecruitmentTranslocationCY -> NUGlycosylationNUMitochondriaCY->EXUbiquitinationMolecular associationEndosomeNucleusDPhosphorylationProteins in a complex interactionGOPalmitoylationCY -> NUMTCYAcetylationInhibitionMethylationDReaction through unknown mechanisms/moleculesEnzyme complexECCytoplasmExtracellularGolgi apparatusDemethylationCY -> NUSumoylationAutophosphorylationMAPK8Traf6TOLLIPCASP1NFKBIAMAP3K7IP2Irak1Traf6RELAIl1aCHUKMAP3K7IP2Il1bPELI1Il1r2MAPK1MAP3K7SirpaMAPK3MAPK1Il1r2MAP3K7SQSTM1NFKBIBIl1rnTraf6Irak2RELAMAP3K7IP1MAP3K7IP1Traf6TOLLIPIrak1PELI1Il1aIRAK4MAP3K7Irak4Il1bIl1rapMAP3K7IP2MAP2K1Il1bAKT1Myd88CAPN1MAP3K14Il1r1MAP3K7Il1bPTPN11Il1r1MAP3K7PTPN11MAP3K7IP1Gene SymbolIrak1CAPNS1IKBKAPIRAK4Il1aIl1aPRKCZIl1rnTraf6Il1r1Irak1Il1r2Traf6CHUKMAP3K7IP2Irak1PLCG1Irak1NFKB1MAP3K14MAP3K7Il1rapSirpaIRAK3MAP3K7IP2MAP3K7IP2NFKBIA


Description

The interleukin 1 family of cytokines includes interleukin-1 alpha (IL1A), beta (IL1B) and the IL-1 receptor antagonist (IL1RN). These bind to the IL-1 receptor (IL1R1) as well as its decoy receptor, IL1R2. Upon binding to the ligands, interleukin-1 alpha or beta, IL1R1 interacts with IL-1 receptor accessory protein (IL1RAP) to activate the MAPK/JNK signaling modules. The MAPK pathway leads to activation of NFkB complex. As both IL-1 and TNF alpha stimulate the MAPK signaling module and activate NFkB, they are synergistic and complement each other's activity. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_13

Comments

GenMAPP notes 
NetPath 13: IL-1 Signaling Pathway

NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published.

GenMAPP remarks 
http://www.netpath.org

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Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
117902view10:28, 23 May 2021EweitzModified title
97052view15:15, 26 April 2018Olivier.traetsLine changes
69141view18:16, 8 July 2013MaintBotUpdated to 2013 gpml schema
67365view10:42, 26 June 2013Christine ChichesterOntology Term : 'interleukin-1 signaling pathway' added !
41331view00:25, 2 March 2011MaintBotRemoved redundant pathway information and comments
35778view06:16, 13 February 2010MaintBotAdded description
20755view11:29, 14 November 2008MaintBot[[Pathway:Mus musculus:IL-1 NetPath 13]] moved to [[Pathway:WP37]]: Moved to stable identifier
8160view13:46, 7 January 2008MaintBot[[Pathway:Mouse:IL-1 NetPath 13]] moved to [[Pathway:Mus musculus:IL-1 NetPath 13]]: Renaming species
7700view16:10, 18 December 2007MaintBotfixed category names
7239view12:41, 4 November 2007MaintBotAdded categories to GPML
6458view22:19, 22 May 2007A.Pandeygpml file for [[Mouse:IL-1_NetPath_13]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProduct11651 (Entrez Gene)
CAPN1GeneProduct12333 (Entrez Gene)
CAPNS1GeneProduct12336 (Entrez Gene)
CASP1GeneProduct12362 (Entrez Gene)
CHUKGeneProduct12675 (Entrez Gene)
Gene SymbolGeneProduct
IKBKAPGeneProduct230233 (Entrez Gene)
IRAK3GeneProduct73914 (Entrez Gene)
IRAK4GeneProduct266632 (Entrez Gene)
Il1aGeneProduct16175 (Entrez Gene)
Il1bGeneProduct16176 (Entrez Gene)
Il1r1GeneProduct16177 (Entrez Gene)
Il1r2GeneProduct16178 (Entrez Gene)
Il1rapGeneProduct16180 (Entrez Gene)
Il1rnGeneProduct16181 (Entrez Gene)
Irak1GeneProduct16179 (Entrez Gene)
Irak2GeneProduct108960 (Entrez Gene)
Irak4GeneProduct266632 (Entrez Gene)
MAP2K1GeneProduct26395 (Entrez Gene)
MAP3K14GeneProduct53859 (Entrez Gene)
MAP3K7GeneProduct26409 (Entrez Gene)
MAP3K7IP1GeneProduct66513 (Entrez Gene)
MAP3K7IP2GeneProduct68652 (Entrez Gene)
MAPK1GeneProduct26413 (Entrez Gene)
MAPK3GeneProduct26417 (Entrez Gene)
MAPK8GeneProduct26419 (Entrez Gene)
Myd88GeneProduct17874 (Entrez Gene)
NFKB1GeneProduct18033 (Entrez Gene)
NFKBIAGeneProduct18035 (Entrez Gene)
NFKBIBGeneProduct18036 (Entrez Gene)
PELI1GeneProduct67245 (Entrez Gene)
PLCG1GeneProduct18803 (Entrez Gene)
PRKCZGeneProduct18762 (Entrez Gene)
PTPN11GeneProduct19247 (Entrez Gene)
RELAGeneProduct19697 (Entrez Gene)
SQSTM1GeneProduct18412 (Entrez Gene)
SirpaGeneProduct19261 (Entrez Gene)
TOLLIPGeneProduct54473 (Entrez Gene)
Traf6GeneProduct22034 (Entrez Gene)

Annotated Interactions

No annotated interactions
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