Glycerophospholipid biosynthetic pathway (Homo sapiens)

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Biosynthesis pathwaysCTP2-acyl-sn-glycero-3-phosphate(Lysophosphatidic acid; LPA)PPiGlycerol-3-phosphate dehydrogenase (NAD+)EC 1.1.1.8CholineEthanolamineNADH + H+PhosphorylethanolamineGlycolysis1,2-diacyl-sn-glycero-3-phosphate(Phosphatidic acid; PA)SerinePiCytidine diphosphate choline(CDP-choline)Adenosine triphosphate(ATP)CoA-SHCytidine monophosphate(CMP)PIP3[3',4',5']Phosphatidylinositol-4-phosphate(PIP)Fatty acid Metabolism3 (S-adenosyl-methionine)1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(PG)1,2-diacyl-sn-glycero-3-phosphoethanolamine(PE)GlucosePIP2[4',5']triacyl-sn-glycerol(Triacylglycerol; TAG)1,2-diacyl-sn-glycero-3-phosphoserine(PS)Dihydroxyacetone phosphate1,2-diacyl-sn-glycero-3-cytidine-5'-diphosphate(CDP-DAG, CMP-PA)Pyrimidine Metabolism1,2-diacyl-sn-glycero-3-phospho-(1'-myo-inositol)(PI)1,2-diacyl-sn-glycerol(1,2-diacylglycerol; 1,2-DAG)InositolD-Glucose-6-PCytidine diphosphate ethanolamine(CDP-ethanolamine)1D-myo-Inositol-1-PNAD+(Coenzyme I)Cardiolipin(DPG, CL)1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-phosphate)(PGP)1,2-diacyl-sn-glycero-3-phosphocholine(PC, Lecithin)Adenosine diphosphate(ADP)Glycerolsn-glycerol-3-phosphate(glycerol-3-P)Phosphocholine(Choline-P)Glycerol-3-PPiCMPCMPATPADPCTPPPiEthanolamineATPADPATPADPATPADPATPADPGlycerol kinaseEC 2.7.1.30Acyl-CoA2-acylglycerol-3-phosphate O-acyltransferaseEC 2.3.1.52Glycerol-3-phosphate 2-O-acyltransferaseEC 2.3.1.198Acyl coenzyme A(Acyl-CoA)Coenzyme A(CoA-SH)Phosphatidate phosphataseEC 3.1.3.4Diacylglycerol O-acyltransferaseEC 2.3.1.20Acyl coenzyme A(Acyl-CoA)Coenzyme A(CoA-SH)Phosphatidate cytidylyltransferaseEC 2.7.7.41Cytidine triphosphate(CTP)PPiCDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferaseEC 2.7.8.5PhosphatidylglycerophosphataseEC 3.1.3.27H2OCardiolipin synthaseEC 2.7.8.-CDP-DAGCMPCDP-diacylglyreol-inositol 3-phosphatidyltransferaseEC 2.7.8.111-phosphatidylinositol 4-kinaseEC 2.7.1.671-phosphatidylinositol 4-phosphate 5-kinaseEC 2.7.1.68Phosphatidylinositol-4,5-bisphosphate 3-kinaseEC 2.7.1.153Choline kinaseEC 2.7.1.32Choline-phosphate cytidylyltransferaseEC 2.7.7.15Diacylglycerol cholinephosphotransferaseEC 2.7.8.2Ethanolamine kinaseEC 2.7.1.82Ethanolamine-phosphate cytidylyltransferaseEC 2.7.7.14EthanolaminephosphotransferaseEC 2.7.8.1L-serine-phosphatidylethanolamine phosphatidyltransferaseEC 2.7.8.29Phosphatidylethanolamine N-methyltransferaseEC 2.1.1.173 (S-adenosylhomocysteine)CMPGlycolysisGlycolysisDegradation pathwaysPathway origin


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  1. Houtkooper RH, Vaz FM; ''Cardiolipin, the heart of mitochondrial metabolism.''; Cell Mol Life Sci, 2008 PubMed Europe PMC Scholia
  2. Cornell RB; ''Cholinephosphotransferase from mammalian sources.''; Methods Enzymol, 1992 PubMed Europe PMC Scholia
  3. Insall RH, Weiner OD; ''PIP3, PIP2, and cell movement--similar messages, different meanings?''; Dev Cell, 2001 PubMed Europe PMC Scholia
  4. Santiago OM, Rosenberg LI, Monaco ME; ''Organization of the phosphoinositide cycle. Assessment of inositol transferase activity in purified plasma membranes.''; Biochem J, 1993 PubMed Europe PMC Scholia
  5. Yamashita S, Hosaka K; ''Choline kinase from yeast.''; Biochim Biophys Acta, 1997 PubMed Europe PMC Scholia
  6. Turkish A, Sturley SL; ''Regulation of triglyceride metabolism. I. Eukaryotic neutral lipid synthesis: "Many ways to skin ACAT or a DGAT".''; Am J Physiol Gastrointest Liver Physiol, 2007 PubMed Europe PMC Scholia
  7. Kawasaki K, Kuge O, Yamakawa Y, Nishijima M; ''Purification of phosphatidylglycerophosphate synthase from Chinese hamster ovary cells.''; Biochem J, 2001 PubMed Europe PMC Scholia
  8. Jambou R, El-Assaad F, Combes V, Grau GE; ''Citicoline (CDP-choline): What role in the treatment of complications of infectious diseases.''; Int J Biochem Cell Biol, 2009 PubMed Europe PMC Scholia
  9. Kooijman EE, Burger KN; ''Biophysics and function of phosphatidic acid: a molecular perspective.''; Biochim Biophys Acta, 2009 PubMed Europe PMC Scholia
  10. Messner MC, Albert CJ, Hsu FF, Ford DA; ''Selective plasmenylcholine oxidation by hypochlorous acid: formation of lysophosphatidylcholine chlorohydrins.''; Chem Phys Lipids, 2006 PubMed Europe PMC Scholia
  11. Ansell GB, Metcalfe RF; ''Studies on the CDP-ethanolamine-1,2-diglyceride ethanolaminephosphotransferase of rat brain.''; J Neurochem, 1971 PubMed Europe PMC Scholia
  12. Li Z, Vance DE; ''Phosphatidylcholine and choline homeostasis.''; J Lipid Res, 2008 PubMed Europe PMC Scholia
  13. Farooqui AA, Yang HC, Horrocks LA; ''Plasmalogens, phospholipases A2 and signal transduction.''; Brain Res Brain Res Rev, 1995 PubMed Europe PMC Scholia
  14. Vance DE; ''Phosphatidylethanolamine N-methyltransferase: unexpected findings from curiosity-driven research.''; Eur J Med Res, 1996 PubMed Europe PMC Scholia
  15. Arthur G, Page L; ''Synthesis of phosphatidylethanolamine and ethanolamine plasmalogen by the CDP-ethanolamine and decarboxylase pathways in rat heart, kidney and liver.''; Biochem J, 1991 PubMed Europe PMC Scholia
  16. Haagsman HP, de Haas CG, Geelen MJ, van Golde LM; ''Regulation of triacylglycerol synthesis in the liver. Modulation of diacylglycerol acyltransferase activity in vitro.''; J Biol Chem, 1982 PubMed Europe PMC Scholia
  17. Heacock AM, Agranoff BW; ''CDP-diacylglycerol synthase from mammalian tissues.''; Biochim Biophys Acta, 1997 PubMed Europe PMC Scholia
  18. Shin JJ, Loewen CJ; ''Putting the pH into phosphatidic acid signaling.''; BMC Biol, 2011 PubMed Europe PMC Scholia
  19. Bleijerveld OB, Brouwers JF, Vaandrager AB, Helms JB, Houweling M; ''The CDP-ethanolamine pathway and phosphatidylserine decarboxylation generate different phosphatidylethanolamine molecular species.''; J Biol Chem, 2007 PubMed Europe PMC Scholia
  20. Singh H, Beckman K, Poulos A; ''Exclusive localization in peroxisomes of dihydroxyacetone phosphate acyltransferase and alkyl-dihydroxyacetone phosphate synthase in rat liver.''; J Lipid Res, 1993 PubMed Europe PMC Scholia
  21. Lapetina EG, Crouch MF; ''The relationship between phospholipases A2 and C in signal transduction.''; Ann N Y Acad Sci, 1989 PubMed Europe PMC Scholia
  22. Agranoff BW, Hajra AK; ''The acyl dihydroxyacetone phosphate pathway for glycerolipid biosynthesis in mouse liver and Ehrlich ascites tumor cells.''; Proc Natl Acad Sci U S A, 1971 PubMed Europe PMC Scholia
  23. Kawasaki K, Nishijima M; ''Purification of phosphatidylglycerophosphate synthase from cultured mammalian cells.''; Methods Mol Biol, 2003 PubMed Europe PMC Scholia
  24. Gonzalvez F, Gottlieb E; ''Cardiolipin: setting the beat of apoptosis.''; Apoptosis, 2007 PubMed Europe PMC Scholia
  25. Tzagournis M; ''Triglycerides in clinical medicine. A review.''; Am J Clin Nutr, 1978 PubMed Europe PMC Scholia
  26. Garcia C, Montero M, Alvarez J, Sanchez Crespo M; ''Biosynthesis of platelet-activating factor (PAF) induced by chemotactic peptide is modulated at the lyso-PAF:acetyl-CoA acetyltransferase level by calcium transient and phosphatidic acid.''; J Biol Chem, 1993 PubMed Europe PMC Scholia
  27. Roberti R, Mancini A, Freysz L, Binaglia L; ''Reversibility of the reactions catalyzed by cholinephosphotransferase and ethanolaminephosphotransferase solubilized from rat-brain microsomes.''; Biochim Biophys Acta, 1992 PubMed Europe PMC Scholia
  28. McGee TP, Skinner HB, Bankaitis VA; ''Functional redundancy of CDP-ethanolamine and CDP-choline pathway enzymes in phospholipid biosynthesis: ethanolamine-dependent effects on steady-state membrane phospholipid composition in Saccharomyces cerevisiae.''; J Bacteriol, 1994 PubMed Europe PMC Scholia
  29. Nakagawa T, Harada N, Miyamoto A, Kawanishi Y, Yoshida M, Shono M, Mawatari K, Takahashi A, Sakaue H, Nakaya Y; ''Membrane topology of murine glycerol-3-phosphate acyltransferase 2.''; Biochem Biophys Res Commun, 2012 PubMed Europe PMC Scholia
  30. Kay JG, Grinstein S; ''Phosphatidylserine-mediated cellular signaling.''; Adv Exp Med Biol, 2013 PubMed Europe PMC Scholia
  31. Bleijerveld OB, Klein W, Vaandrager AB, Helms JB, Houweling M; ''Control of the CDPethanolamine pathway in mammalian cells: effect of CTP:phosphoethanolamine cytidylyltransferase overexpression and the amount of intracellular diacylglycerol.''; Biochem J, 2004 PubMed Europe PMC Scholia
  32. De Matteis MA, Wilson C, D'Angelo G; ''Phosphatidylinositol-4-phosphate: The Golgi and beyond.''; Bioessays, 2013 PubMed Europe PMC Scholia
  33. Roberti R, Vecchini A, Freysz L, Masoom M, Binaglia L; ''An improved procedure for the purification of ethanolaminephosphotransferase. Reconstitution of the purified enzyme with lipids.''; Biochim Biophys Acta, 1989 PubMed Europe PMC Scholia
  34. Vance JE; ''Phosphatidylserine and phosphatidylethanolamine in mammalian cells: two metabolically related aminophospholipids.''; J Lipid Res, 2008 PubMed Europe PMC Scholia
  35. Heilmeyer LM Jr, Vereb G Jr, Vereb G, Kakuk A, Szivák I; ''Mammalian phosphatidylinositol 4-kinases.''; IUBMB Life, 2003 PubMed Europe PMC Scholia
  36. Claypool SM, Koehler CM; ''The complexity of cardiolipin in health and disease.''; Trends Biochem Sci, 2012 PubMed Europe PMC Scholia
  37. Carrasco S, Mérida I; ''Diacylglycerol, when simplicity becomes complex.''; Trends Biochem Sci, 2007 PubMed Europe PMC Scholia
  38. El-Bassiouni EA, Piantadosi C, Snyder F; ''Metabolism of alkyldihydroxyacetone phosphate in rat brain.''; Biochim Biophys Acta, 1975 PubMed Europe PMC Scholia
  39. van den Bosch H, Aarsman AJ, van Schaik RH, Schalkwijk CG, Neijs FW, Sturk A; ''Structural and enzymological properties of cellular phospholipases A2.''; Biochem Soc Trans, 1990 PubMed Europe PMC Scholia
  40. McMaster CR, Bell RM; ''CDP-ethanolamine:1,2-diacylglycerol ethanolaminephosphotransferase.''; Biochim Biophys Acta, 1997 PubMed Europe PMC Scholia
  41. Patil VA, Greenberg ML; ''Cardiolipin-mediated cellular signaling.''; Adv Exp Med Biol, 2013 PubMed Europe PMC Scholia
  42. Zimmerman GA, Elstad MR, Lorant DE, Mclntyre TM, Prescott SM, Topham MK, Weyrich AS, Whatley RE; ''Platelet-activating factor (PAF): signalling and adhesion in cell-cell interactions.''; Adv Exp Med Biol, 1996 PubMed Europe PMC Scholia
  43. Coleman R, Bell RM; ''Phospholipid synthesis in isolated fat cells. Studies of microsomal diacylglycerol cholinephosphotransferase and diacylglycerol ethanolaminephosphotransferase activities.''; J Biol Chem, 1977 PubMed Europe PMC Scholia
  44. Arthur G, Page L, Mock T, Choy PC; ''The catabolism of plasmenylcholine in the guinea pig heart.''; Biochem J, 1986 PubMed Europe PMC Scholia
  45. Kulikov VI, Muzya GI; ''The bioregulatory role of platelet-activating factor in intracellular processes and cell-cell interactions.''; Biochemistry (Mosc), 1998 PubMed Europe PMC Scholia
  46. Ishidate K; ''Choline/ethanolamine kinase from mammalian tissues.''; Biochim Biophys Acta, 1997 PubMed Europe PMC Scholia
  47. Hjelmstad RH, Morash SC, McMaster CR, Bell RM; ''Chimeric enzymes. Structure-function analysis of segments of sn-1,2-diacylglycerol choline- and ethanolaminephosphotransferases.''; J Biol Chem, 1994 PubMed Europe PMC Scholia
  48. Snyder F; ''CDP-choline:alkylacetylglycerol cholinephosphotransferase catalyzes the final step in the de novo synthesis of platelet-activating factor.''; Biochim Biophys Acta, 1997 PubMed Europe PMC Scholia
  49. Nagan N, Zoeller RA; ''Plasmalogens: biosynthesis and functions.''; Prog Lipid Res, 2001 PubMed Europe PMC Scholia
  50. Balla T; ''Phosphatidylinositol 4-kinases.''; Biochim Biophys Acta, 1998 PubMed Europe PMC Scholia
  51. Koltai M, Hosford D, Guinot P, Esanu A, Braquet P; ''Platelet activating factor (PAF). A review of its effects, antagonists and possible future clinical implications (Part I).''; Drugs, 1991 PubMed Europe PMC Scholia
  52. Brindley DN, Pilquil C, Sariahmetoglu M, Reue K; ''Phosphatidate degradation: phosphatidate phosphatases (lipins) and lipid phosphate phosphatases.''; Biochim Biophys Acta, 2009 PubMed Europe PMC Scholia
  53. Ishidate K, Matsuo R, Nakazawa Y; ''CDP-choline: 1,2-diacylglycerol cholinephosphotransferase from rat liver microsomes. II. Photoaffinity labeling by radioactive CDP-choline analogs.''; Biochim Biophys Acta, 1992 PubMed Europe PMC Scholia
  54. Cole LK, Vance JE, Vance DE; ''Phosphatidylcholine biosynthesis and lipoprotein metabolism.''; Biochim Biophys Acta, 2012 PubMed Europe PMC Scholia
  55. Gehrmann T, Heilmeyer LM Jr; ''Phosphatidylinositol 4-kinases.''; Eur J Biochem, 1998 PubMed Europe PMC Scholia
  56. Maurice A, Malgat M; ''Phosphatidylethanolamine: ceramide-ethanolaminephosphotransferase activity in synaptic plasma membrane vesicles. Influence of some cations and phospholipid environment on transferase activity. Further proof of its location.''; Int J Biochem, 1993 PubMed Europe PMC Scholia
  57. Han XL, Gross RW; ''Plasmenylcholine and phosphatidylcholine membrane bilayers possess distinct conformational motifs.''; Biochemistry, 1990 PubMed Europe PMC Scholia
  58. Diagne A, Fauvel J, Record M, Chap H, Douste-Blazy L; ''Studies on ether phospholipids. II. Comparative composition of various tissues from human, rat and guinea pig.''; Biochim Biophys Acta, 1984 PubMed Europe PMC Scholia
  59. Mackenzie CG, Reiss OK, Moritz E, Mackenzie JB; ''Metabolism of glycerol monoethers in cultured liver cells and implications for monoglyceride pathways.''; J Lipid Res, 1976 PubMed Europe PMC Scholia
  60. Siegel A, Baker RR; ''Activities of enzymes in platelet activating factor biosynthetic pathways in the gerbil model of cerebral ischemia.''; Biochem Cell Biol, 1996 PubMed Europe PMC Scholia
  61. Spencer DA; ''An update on PAF.''; Clin Exp Allergy, 1992 PubMed Europe PMC Scholia
  62. Clement JM, Kent C; ''CTP:phosphocholine cytidylyltransferase: insights into regulatory mechanisms and novel functions.''; Biochem Biophys Res Commun, 1999 PubMed Europe PMC Scholia
  63. Piantadosi C, Ishaq KS, Wykle RL, Snyder F; ''Synthesis and characterization of 1-O-alkyldihydroxyacetone phosphates and derivatives.''; Biochemistry, 1971 PubMed Europe PMC Scholia
  64. Polokoff MA, Bell RM; ''Solubilization, partial purification and characterization of rat liver microsomal diacylglycerol acyltransferase.''; Biochim Biophys Acta, 1980 PubMed Europe PMC Scholia
  65. Bru R, Blöchliger E, Luisi PL; ''sn-1,2-diacylglycerol cholinephosphotransferase from pig liver: mixed micellar assay and kinetic analysis of the partially pure enzyme.''; Arch Biochem Biophys, 1993 PubMed Europe PMC Scholia
  66. Coleman RA; ''Diacylglycerol acyltransferase and monoacylglycerol acyltransferase from liver and intestine.''; Methods Enzymol, 1992 PubMed Europe PMC Scholia
  67. Henneberry AL, Wistow G, McMaster CR; ''Cloning, genomic organization, and characterization of a human cholinephosphotransferase.''; J Biol Chem, 2000 PubMed Europe PMC Scholia
  68. Edwards YH, Shaw MA; ''The isozymes of membrane-associated enzymes: acetylcholinesterase, succinate dehydrogenase, and glycerol-3-phosphate dehydrogenase.''; Isozymes Curr Top Biol Med Res, 1983 PubMed Europe PMC Scholia
  69. Whatley RE, Clay KL, Chilton FH, Triggiani M, Zimmerman GA, McIntyre TM, Prescott SM; ''Relative amounts of 1-O-alkyl- and 1-acyl-2-acetyl-sn-glycero-3-phosphocholine in stimulated endothelial cells.''; Prostaglandins, 1992 PubMed Europe PMC Scholia
  70. Ford DA, Gross RW; ''Plasmenylethanolamine is the major storage depot for arachidonic acid in rabbit vascular smooth muscle and is rapidly hydrolyzed after angiotensin II stimulation.''; Proc Natl Acad Sci U S A, 1989 PubMed Europe PMC Scholia
  71. Koynova R, Caffrey M; ''Phases and phase transitions of the hydrated phosphatidylethanolamines.''; Chem Phys Lipids, 1994 PubMed Europe PMC Scholia
  72. Alarcon DA, Nandi M, Carpena X, Fita I, Loewen PC; ''Structure of glycerol-3-phosphate dehydrogenase (GPD1) from Saccharomyces cerevisiae at 2.45 Å resolution.''; Acta Crystallogr Sect F Struct Biol Cryst Commun, 2012 PubMed Europe PMC Scholia
  73. Chicco AJ, Sparagna GC; ''Role of cardiolipin alterations in mitochondrial dysfunction and disease.''; Am J Physiol Cell Physiol, 2007 PubMed Europe PMC Scholia
  74. Fariss MW, Chan CB, Patel M, Van Houten B, Orrenius S; ''Role of mitochondria in toxic oxidative stress.''; Mol Interv, 2005 PubMed Europe PMC Scholia
  75. Schümperli M, Pellaux R, Panke S; ''Chemical and enzymatic routes to dihydroxyacetone phosphate.''; Appl Microbiol Biotechnol, 2007 PubMed Europe PMC Scholia
  76. de Vet EC, Ijlst L, Oostheim W, Dekker C, Moser HW, van Den Bosch H, Wanders RJ; ''Ether lipid biosynthesis: alkyl-dihydroxyacetonephosphate synthase protein deficiency leads to reduced dihydroxyacetonephosphate acyltransferase activities.''; J Lipid Res, 1999 PubMed Europe PMC Scholia
  77. Jones AR, Gillan L; ''Metabolism of glycerol 3-phosphate by mature boar spermatozoa.''; J Reprod Fertil, 1996 PubMed Europe PMC Scholia
  78. Snyder F; ''Metabolism of platelet activating factor and related ether lipids: enzymatic pathways, subcellular sites, regulation, and membrane processing.''; Prog Clin Biol Res, 1988 PubMed Europe PMC Scholia
  79. Nojima S; ''Platelet-activating factor (PAF): an introduction.''; Lipids, 1991 PubMed Europe PMC Scholia
  80. Delage E, Puyaubert J, Zachowski A, Ruelland E; ''Signal transduction pathways involving phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate: convergences and divergences among eukaryotic kingdoms.''; Prog Lipid Res, 2013 PubMed Europe PMC Scholia
  81. de Vet EC, van den Bosch H; ''Alkyl-dihydroxyacetonephosphate synthase.''; Cell Biochem Biophys, 2000 PubMed Europe PMC Scholia
  82. Axelrod J; ''Phospholipase A2 and G proteins.''; Trends Neurosci, 1995 PubMed Europe PMC Scholia
  83. Willier S, Butt E, Grunewald TG; ''Lysophosphatidic acid (LPA) signalling in cell migration and cancer invasion: A focussed review and analysis of LPA receptor gene expression on the basis of more than 1700 cancer microarrays.''; Biol Cell, 2013 PubMed Europe PMC Scholia
  84. Tufano MA, Biancone L, Rossano F, Capasso C, Baroni A, De Martino A, Iorio EL, Silvestro L, Camussi G; ''Outer-membrane porins from gram-negative bacteria stimulate platelet-activating-factor biosynthesis by cultured human endothelial cells.''; Eur J Biochem, 1993 PubMed Europe PMC Scholia
  85. Lykidis A, Wang J, Karim MA, Jackowski S; ''Overexpression of a mammalian ethanolamine-specific kinase accelerates the CDP-ethanolamine pathway.''; J Biol Chem, 2001 PubMed Europe PMC Scholia
  86. D'Angelo G, Vicinanza M, Di Campli A, De Matteis MA; ''The multiple roles of PtdIns(4)P -- not just the precursor of PtdIns(4,5)P2.''; J Cell Sci, 2008 PubMed Europe PMC Scholia
  87. Thomas JR, Dwek RA, Rademacher TW; ''Structure, biosynthesis, and function of glycosylphosphatidylinositols.''; Biochemistry, 1990 PubMed Europe PMC Scholia
  88. Vance DE, Walkey CJ, Agellon LB; ''Why has phosphatidylethanolamine N-methyltransferase survived in evolution?''; Biochem Soc Trans, 1998 PubMed Europe PMC Scholia
  89. Hoch FL; ''Cardiolipins and biomembrane function.''; Biochim Biophys Acta, 1992 PubMed Europe PMC Scholia
  90. Grimm MO, Kuchenbecker J, Rothhaar TL, Grösgen S, Hundsdörfer B, Burg VK, Friess P, Müller U, Grimm HS, Riemenschneider M, Hartmann T; ''Plasmalogen synthesis is regulated via alkyl-dihydroxyacetonephosphate-synthase by amyloid precursor protein processing and is affected in Alzheimer's disease.''; J Neurochem, 2011 PubMed Europe PMC Scholia
  91. Zhang L, Mao YS, Janmey PA, Yin HL; ''Phosphatidylinositol 4, 5 bisphosphate and the actin cytoskeleton.''; Subcell Biochem, 2012 PubMed Europe PMC Scholia
  92. Das AK, Hajra AK; ''Estimation of acyldihydroxyacetone phosphate and lysophosphatidate in animal tissues.''; Biochim Biophys Acta, 1984 PubMed Europe PMC Scholia
  93. Gale SE, Frolov A, Han X, Bickel PE, Cao L, Bowcock A, Schaffer JE, Ory DS; ''A regulatory role for 1-acylglycerol-3-phosphate-O-acyltransferase 2 in adipocyte differentiation.''; J Biol Chem, 2006 PubMed Europe PMC Scholia
  94. Koltai M, Hosford D, Guinot P, Esanu A, Braquet P; ''PAF. A review of its effects, antagonists and possible future clinical implications (Part II).''; Drugs, 1991 PubMed Europe PMC Scholia
  95. Shin J, Thompson DH; ''Direct synthesis of plasmenylcholine from allyl-substituted glycerols.''; J Org Chem, 2003 PubMed Europe PMC Scholia
  96. Snyder F; ''Metabolic processing of PAF.''; Clin Rev Allergy, 1994 PubMed Europe PMC Scholia
  97. Kume K, Shimizu T; ''cDNA cloning and expression of murine 1-acyl-sn-glycerol-3-phosphate acyltransferase.''; Biochem Biophys Res Commun, 1997 PubMed Europe PMC Scholia
  98. Vance DE; ''Physiological roles of phosphatidylethanolamine N-methyltransferase.''; Biochim Biophys Acta, 2013 PubMed Europe PMC Scholia
  99. Downes CP, Carter AN; ''Inositol lipids and phosphates.''; Curr Opin Cell Biol, 1990 PubMed Europe PMC Scholia
  100. Hjelmstad RH, Bell RM; ''The sn-1,2-diacylglycerol cholinephosphotransferase of Saccharomyces cerevisiae. Nucleotide sequence, transcriptional mapping, and gene product analysis of the CPT1 gene.''; J Biol Chem, 1990 PubMed Europe PMC Scholia
  101. Moolenaar WH; ''Lysophosphatidic acid, a multifunctional phospholipid messenger.''; J Biol Chem, 1995 PubMed Europe PMC Scholia
  102. Liteplo RG, Sribney M; ''The stimulation of rat liver microsomal CTP: phosphatidate cytidylyltransferase activity by guanosine triphosphate.''; Biochim Biophys Acta, 1980 PubMed Europe PMC Scholia
  103. Kent C; ''Eukaryotic phospholipid biosynthesis.''; Annu Rev Biochem, 1995 PubMed Europe PMC Scholia
  104. Xu YF, O K, Choy PC; ''Plasmenylcholine (1-O-alk-1'-enyl-2-acyl-sn-glycero-3-phosphocholine) biosynthesis in guinea-pig heart and liver: cholinephosphotransferase is a bifunctional enzyme for the synthesis of phosphatidylcholine and plasmenylcholine.''; Biochem J, 1994 PubMed Europe PMC Scholia
  105. Hsuan JJ, Minogue S, dos Santos M; ''Phosphoinositide 4- and 5-kinases and the cellular roles of phosphatidylinositol 4,5-bisphosphate.''; Adv Cancer Res, 1998 PubMed Europe PMC Scholia
  106. Lucken-Ardjomande Hasler S; ''Cholesterol, cardiolipin, and mitochondria permeabilisation.''; Anticancer Agents Med Chem, 2012 PubMed Europe PMC Scholia
  107. Tijburg LB, Vermeulen PS, van Golde LM; ''Ethanolamine-phosphate cytidylyltransferase.''; Methods Enzymol, 1992 PubMed Europe PMC Scholia
  108. Schlame M, Greenberg ML; ''Cardiolipin synthase from yeast.''; Biochim Biophys Acta, 1997 PubMed Europe PMC Scholia
  109. Farese RV Jr, Cases S, Smith SJ; ''Triglyceride synthesis: insights from the cloning of diacylglycerol acyltransferase.''; Curr Opin Lipidol, 2000 PubMed Europe PMC Scholia
  110. Kocsis MG, Weselake RJ; ''Phosphatidate phosphatases of mammals, yeast, and higher plants.''; Lipids, 1996 PubMed Europe PMC Scholia
  111. Lamers JM, Dekkers DH, Bezstarosti K, Meij JT, van Heugten HA; ''Occurrence and functions of the phosphatidylinositol cycle in the myocardium.''; Mol Cell Biochem, 1992 PubMed Europe PMC Scholia
  112. Graham TR, Burd CG; ''Coordination of Golgi functions by phosphatidylinositol 4-kinases.''; Trends Cell Biol, 2011 PubMed Europe PMC Scholia
  113. Kwiatkowska K; ''One lipid, multiple functions: how various pools of PI(4,5)P(2) are created in the plasma membrane.''; Cell Mol Life Sci, 2010 PubMed Europe PMC Scholia
  114. Gibellini F, Smith TK; ''The Kennedy pathway--De novo synthesis of phosphatidylethanolamine and phosphatidylcholine.''; IUBMB Life, 2010 PubMed Europe PMC Scholia
  115. Ramanadham S, Bohrer A, Mueller M, Jett P, Gross RW, Turk J; ''Mass spectrometric identification and quantitation of arachidonate-containing phospholipids in pancreatic islets: prominence of plasmenylethanolamine molecular species.''; Biochemistry, 1993 PubMed Europe PMC Scholia
  116. Pagès C, Simon M, Valet P, Saulnier-Blache JS; ''Lysophosphatidic acid synthesis and release(1).''; Prostaglandins, 2001 PubMed Europe PMC Scholia
  117. Gamper N, Shapiro MS; ''Target-specific PIP(2) signalling: how might it work?''; J Physiol, 2007 PubMed Europe PMC Scholia
  118. Pagès C, Simon MF, Valet P, Saulnier-Blache JS; ''Lysophosphatidic acid synthesis and release.''; Prostaglandins Other Lipid Mediat, 2001 PubMed Europe PMC Scholia
  119. Roberti R, Binaglia L, Francescangeli E, Goracci G, Porcellati G; ''Enzymic synthesis of 1-alkyl-2-acyl-sn-glycero-3-phosphorylethanolamine through ethanolaminephosphotransferase activity in the neuronal and glial cells of rabbit in vitro.''; Lipids, 1975 PubMed Europe PMC Scholia
  120. Divecha N; ''Lipid kinases: charging PtdIns(4,5)P2 synthesis.''; Curr Biol, 2010 PubMed Europe PMC Scholia
  121. Gibbons GF, Islam K, Pease RJ; ''Mobilisation of triacylglycerol stores.''; Biochim Biophys Acta, 2000 PubMed Europe PMC Scholia
  122. Clayton EL, Minogue S, Waugh MG; ''Phosphatidylinositol 4-kinases and PI4P metabolism in the nervous system: roles in psychiatric and neurological diseases.''; Mol Neurobiol, 2013 PubMed Europe PMC Scholia
  123. Yost CC, Weyrich AS, Zimmerman GA; ''The platelet activating factor (PAF) signaling cascade in systemic inflammatory responses.''; Biochimie, 2010 PubMed Europe PMC Scholia
  124. Holmsen H, Hindenes JO, Fukami M; ''Glycerophospholipid metabolism: back to the future.''; Thromb Res, 1992 PubMed Europe PMC Scholia
  125. Tijburg LB, Geelen MJ, Van Golde LM; ''Biosynthesis of phosphatidylethanolamine via the CDP-ethanolamine route is an important pathway in isolated rat hepatocytes.''; Biochem Biophys Res Commun, 1989 PubMed Europe PMC Scholia
  126. Detopoulou P, Nomikos T, Fragopoulou E, Antonopoulou S, Kotroyiannis I, Vassiliadou C, Panagiotakos DB, Chrysohoou C, Pitsavos C, Stefanadis C; ''Platelet activating factor (PAF) and activity of its biosynthetic and catabolic enzymes in blood and leukocytes of male patients with newly diagnosed heart failure.''; Clin Biochem, 2009 PubMed Europe PMC Scholia
  127. Kay JG, Grinstein S; ''Sensing phosphatidylserine in cellular membranes.''; Sensors (Basel), 2011 PubMed Europe PMC Scholia
  128. Schlame M, Hostetler KY; ''Cardiolipin synthase from mammalian mitochondria.''; Biochim Biophys Acta, 1997 PubMed Europe PMC Scholia
  129. Tijburg LB, Geelen MJ, van Golde LM; ''Regulation of the biosynthesis of triacylglycerol, phosphatidylcholine and phosphatidylethanolamine in the liver.''; Biochim Biophys Acta, 1989 PubMed Europe PMC Scholia
  130. Jiang F, Kelly BL, Hagopian K, Greenberg ML; ''Purification and characterization of phosphatidylglycerolphosphate synthase from Schizosaccharomyces pombe.''; J Biol Chem, 1998 PubMed Europe PMC Scholia
  131. Schlame M, Ren M; ''The role of cardiolipin in the structural organization of mitochondrial membranes.''; Biochim Biophys Acta, 2009 PubMed Europe PMC Scholia
  132. Dircks LK, Sul HS; ''Mammalian mitochondrial glycerol-3-phosphate acyltransferase.''; Biochim Biophys Acta, 1997 PubMed Europe PMC Scholia
  133. Hajra AK, Das AK; ''Lipid biosynthesis in peroxisomes.''; Ann N Y Acad Sci, 1996 PubMed Europe PMC Scholia
  134. Haagsman HP, de Haas CG, Geelen MJ, van Golde LM; ''Regulation of triacylglycerol synthesis in the liver: a decrease in diacylglycerol acyltransferase activity after treatment of isolated rat hepatocytes with glucagon.''; Biochim Biophys Acta, 1981 PubMed Europe PMC Scholia
  135. Sims SM, Panupinthu N, Lapierre DM, Pereverzev A, Dixon SJ; ''Lysophosphatidic acid: a potential mediator of osteoblast-osteoclast signaling in bone.''; Biochim Biophys Acta, 2013 PubMed Europe PMC Scholia
  136. McMaster CR, Bell RM; ''CDP-choline:1,2-diacylglycerol cholinephosphotransferase.''; Biochim Biophys Acta, 1997 PubMed Europe PMC Scholia
  137. Ishii S, Shimizu T; ''Platelet-activating factor (PAF) receptor and genetically engineered PAF receptor mutant mice.''; Prog Lipid Res, 2000 PubMed Europe PMC Scholia
  138. MacDonald PM, McMurray WC; ''Partial purification and properties of mammalian phosphatidylglycerophosphatase.''; Biochim Biophys Acta, 1980 PubMed Europe PMC Scholia
  139. Vance DE, Li Z, Jacobs RL; ''Hepatic phosphatidylethanolamine N-methyltransferase, unexpected roles in animal biochemistry and physiology.''; J Biol Chem, 2007 PubMed Europe PMC Scholia
  140. Hajra AK; ''Dihydroxyacetone phosphate acyltransferase.''; Biochim Biophys Acta, 1997 PubMed Europe PMC Scholia
  141. Paradies G, Petrosillo G, Paradies V, Ruggiero FM; ''Oxidative stress, mitochondrial bioenergetics, and cardiolipin in aging.''; Free Radic Biol Med, 2010 PubMed Europe PMC Scholia
  142. Blank ML, Fitzgerald V, Lee TC, Snyder F; ''Evidence for biosynthesis of plasmenylcholine from plasmenylethanolamine in HL-60 cells.''; Biochim Biophys Acta, 1993 PubMed Europe PMC Scholia
  143. Bewley GC, Cook JL; ''Molecular structure, developmental regulation, and evolution of the gene encoding glycerol-3-phosphate dehydrogenase isozymes in Drosophila melanogaster.''; Prog Clin Biol Res, 1990 PubMed Europe PMC Scholia
  144. Czech MP; ''PIP2 and PIP3: complex roles at the cell surface.''; Cell, 2000 PubMed Europe PMC Scholia
  145. Takenawa T, Itoh T, Fukami K; ''Regulation of phosphatidylinositol 4,5-bisphosphate levels and its roles in cytoskeletal re-organization and malignant transformation.''; Chem Phys Lipids, 1999 PubMed Europe PMC Scholia
  146. Baker RR, Chang HY; ''Alkylglycerophosphate acetyltransferase and lyso platelet activating factor acetyltransferase, two key enzymes in the synthesis of platelet activating factor, are found in neuronal nuclei isolated from cerebral cortex.''; Biochim Biophys Acta, 1996 PubMed Europe PMC Scholia
  147. Sinha Roy S, Mukhopadhyay S, Mukherjee S, Das SK; ''Breast cancer is associated with an increase in the activity and expression of cholinephosphotransferase in rats.''; Life Sci, 2008 PubMed Europe PMC Scholia
  148. Nakanishi K, Yasugi E, Morita H, Dohi T, Oshima M; ''Plasmenylethanolamine in human intestinal mucosa detected by an improved method for analysis of phospholipid.''; Biochem Mol Biol Int, 1994 PubMed Europe PMC Scholia
  149. de Vet EC, Hilkes YH, Fraaije MW, van den Bosch H; ''Alkyl-dihydroxyacetonephosphate synthase. Presence and role of flavin adenine dinucleotide.''; J Biol Chem, 2000 PubMed Europe PMC Scholia
  150. Leventis PA, Grinstein S; ''The distribution and function of phosphatidylserine in cellular membranes.''; Annu Rev Biophys, 2010 PubMed Europe PMC Scholia
  151. Thompson DH, Shin J, Boomer J, Kim JM; ''Preparation of plasmenylcholine lipids and plasmenyl-type liposome dispersions.''; Methods Enzymol, 2004 PubMed Europe PMC Scholia
  152. Zhao Y, Natarajan V; ''Lysophosphatidic acid (LPA) and its receptors: role in airway inflammation and remodeling.''; Biochim Biophys Acta, 2013 PubMed Europe PMC Scholia
  153. Murakami M, Lambeau G; ''Emerging roles of secreted phospholipase A(2) enzymes: an update.''; Biochimie, 2013 PubMed Europe PMC Scholia
  154. Nikawa J, Yamashita S; ''Molecular cloning of the gene encoding CDPdiacylglycerol-inositol 3-phosphatidyl transferase in Saccharomyces cerevisiae.''; Eur J Biochem, 1984 PubMed Europe PMC Scholia
  155. Rooney SA; ''Lung surfactant.''; Environ Health Perspect, 1984 PubMed Europe PMC Scholia
  156. Reue K, Brindley DN; ''Thematic Review Series: Glycerolipids. Multiple roles for lipins/phosphatidate phosphatase enzymes in lipid metabolism.''; J Lipid Res, 2008 PubMed Europe PMC Scholia
  157. Kashiwada M, Lu P, Rothman PB; ''PIP3 pathway in regulatory T cells and autoimmunity.''; Immunol Res, 2007 PubMed Europe PMC Scholia
  158. Hirasawa K, Nishizuka Y; ''Phosphatidylinositol turnover in receptor mechanism and signal transduction.''; Annu Rev Pharmacol Toxicol, 1985 PubMed Europe PMC Scholia
  159. Snyder F, Fitzgerald V, Blank ML; ''Biosynthesis of platelet-activating factor and enzyme inhibitors.''; Adv Exp Med Biol, 1996 PubMed Europe PMC Scholia
  160. Wright MM, McMaster CR; ''PC and PE synthesis: mixed micellar analysis of the cholinephosphotransferase and ethanolaminephosphotransferase activities of human choline/ethanolamine phosphotransferase 1 (CEPT1).''; Lipids, 2002 PubMed Europe PMC Scholia
  161. Talmud PJ; ''Genetic determinants of plasma triglycerides: impact of rare and common mutations.''; Curr Atheroscler Rep, 2001 PubMed Europe PMC Scholia
  162. Clark JD, Schievella AR, Nalefski EA, Lin LL; ''Cytosolic phospholipase A2.''; J Lipid Mediat Cell Signal, 1995 PubMed Europe PMC Scholia
  163. Vance JE, Steenbergen R; ''Metabolism and functions of phosphatidylserine.''; Prog Lipid Res, 2005 PubMed Europe PMC Scholia
  164. Thompson RJ; ''The biosynthesis of cytidine diphosphate diacylglycerol in the mammalian cerebral cortex.''; Biochem Soc Trans, 1977 PubMed Europe PMC Scholia
  165. Lee TC, Qian CG, Snyder F; ''Biosynthesis of choline plasmalogens in neonatal rat myocytes.''; Arch Biochem Biophys, 1991 PubMed Europe PMC Scholia
  166. Wykle RL, Schremmer JM; ''Biosynthesis of plasmalogens by the microsomal fraction of fischer R-3259 sarcoma. Influence of specific 2-acyl chains on the desaturation of 1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine.''; Biochemistry, 1979 PubMed Europe PMC Scholia
  167. Taguchi T, Arai H; ''[Emerging roles of intracellular phosphatidylserine (PS) in membrane traffic].''; Seikagaku, 2012 PubMed Europe PMC Scholia
  168. Waugh MG; ''Phosphatidylinositol 4-kinases, phosphatidylinositol 4-phosphate and cancer.''; Cancer Lett, 2012 PubMed Europe PMC Scholia
  169. Antonsson B; ''Phosphatidylinositol synthase from mammalian tissues.''; Biochim Biophys Acta, 1997 PubMed Europe PMC Scholia
  170. Snyder F, Lee TC; ''1-alkyl-2-acetyl-sn-glycero-3-phosphate phosphatase.''; Methods Enzymol, 1992 PubMed Europe PMC Scholia
  171. de Vet EC, Ijlst L, Oostheim W, Wanders RJ, van den Bosch H; ''Alkyl-dihydroxyacetonephosphate synthase. Fate in peroxisome biogenesis disorders and identification of the point mutation underlying a single enzyme deficiency.''; J Biol Chem, 1998 PubMed Europe PMC Scholia
  172. Hajra AK, Datta SC, Ghosh MK; ''Acyl/alkyldihydroxyacetone phosphate reductase from guinea pig liver peroxisomes.''; Methods Enzymol, 1992 PubMed Europe PMC Scholia
  173. Goñi FM, Alonso A; ''Structure and functional properties of diacylglycerols in membranes.''; Prog Lipid Res, 1999 PubMed Europe PMC Scholia
  174. Rudkowska I, Roynette CE, Demonty I, Vanstone CA, Jew S, Jones PJ; ''Diacylglycerol: efficacy and mechanism of action of an anti-obesity agent.''; Obes Res, 2005 PubMed Europe PMC Scholia
  175. Webber KO, Hajra AK; ''Dihydroxyacetone phosphate acyltransferase.''; Methods Enzymol, 1992 PubMed Europe PMC Scholia
  176. Carman GM; ''Phosphatidate phosphatases and diacylglycerol pyrophosphate phosphatases in Saccharomyces cerevisiae and Escherichia coli.''; Biochim Biophys Acta, 1997 PubMed Europe PMC Scholia
  177. Xu FY, O K, Choy PC; ''Biosynthesis of plasmenylethanolamine (1-O-alk-1'-enyl-2-acyl-sn-glycero-3-phosphoethanolamine) in the guinea pig heart.''; J Lipid Res, 1997 PubMed Europe PMC Scholia
  178. Fagone P, Jackowski S; ''Phosphatidylcholine and the CDP-choline cycle.''; Biochim Biophys Acta, 2013 PubMed Europe PMC Scholia
  179. Secades JJ, Lorenzo JL; ''Citicoline: pharmacological and clinical review, 2006 update.''; Methods Find Exp Clin Pharmacol, 2006 PubMed Europe PMC Scholia
  180. Hullin-Matsuda F, Kawasaki K, Delton-Vandenbroucke I, Xu Y, Nishijima M, Lagarde M, Schlame M, Kobayashi T; ''De novo biosynthesis of the late endosome lipid, bis(monoacylglycero)phosphate.''; J Lipid Res, 2007 PubMed Europe PMC Scholia
  181. Debeer LJ, Declercq PE, Mannaerts GP; ''Glycerol-3-phosphate content and triacylglycerol synthesis in isolated hepatocytes from fed and starved rats.''; FEBS Lett, 1981 PubMed Europe PMC Scholia
  182. Schlegel RA, Williamson P; ''P.S. to PS (phosphatidylserine)--pertinent proteins in apoptotic cell clearance.''; Sci STKE, 2007 PubMed Europe PMC Scholia
  183. Ellis JM, Paul DS, Depetrillo MA, Singh BP, Malarkey DE, Coleman RA; ''Mice deficient in glycerol-3-phosphate acyltransferase-1 have a reduced susceptibility to liver cancer.''; Toxicol Pathol, 2012 PubMed Europe PMC Scholia
  184. Carman GM, Han GS; ''Roles of phosphatidate phosphatase enzymes in lipid metabolism.''; Trends Biochem Sci, 2006 PubMed Europe PMC Scholia
  185. Nieto ML, Velasco S, Sanchez Crespo M; ''Modulation of acetyl-CoA:1-alkyl-2-lyso-sn-glycero-3-phosphocholine (lyso-PAF) acetyltransferase in human polymorphonuclears. The role of cyclic AMP-dependent and phospholipid sensitive, calcium-dependent protein kinases.''; J Biol Chem, 1988 PubMed Europe PMC Scholia
  186. Chao W, Olson MS; ''Platelet-activating factor: receptors and signal transduction.''; Biochem J, 1993 PubMed Europe PMC Scholia
  187. Sukumaran S, Barnes RI, Garg A, Agarwal AK; ''Functional characterization of the human 1-acylglycerol-3-phosphate-O-acyltransferase isoform 10/glycerol-3-phosphate acyltransferase isoform 3.''; J Mol Endocrinol, 2009 PubMed Europe PMC Scholia
  188. Giudici ML, Hinchliffe KA, Irvine RF; ''Phosphatidylinositol phosphate kinases.''; J Endocrinol Invest, 2004 PubMed Europe PMC Scholia
  189. Rüdiger M, Kolleck I, Putz G, Wauer RR, Stevens P, Rüstow B; ''Plasmalogens effectively reduce the surface tension of surfactant-like phospholipid mixtures.''; Am J Physiol, 1998 PubMed Europe PMC Scholia
  190. van Heusden GP, van den Bosch H; ''The influence of exogenous and of membrane-bound phosphatidate concentration on the activity of CTP: phosphatidate cytidylyltransferase and phosphatidate phosphohydrolase.''; Eur J Biochem, 1978 PubMed Europe PMC Scholia
  191. Arienti G, Goracci G, Porcellati G; ''Glycerophospholipid metabolism in neuronal and glial cell-enriched fractions.''; Neurochem Res, 1981 PubMed Europe PMC Scholia
  192. Sorger D, Daum G; ''Triacylglycerol biosynthesis in yeast.''; Appl Microbiol Biotechnol, 2003 PubMed Europe PMC Scholia
  193. Longmuir KJ, Johnston JM; ''Changes in CTP:phosphatidate cytidylyltransferase activity during rabbit lung development.''; Biochim Biophys Acta, 1980 PubMed Europe PMC Scholia
  194. Horibata Y, Hirabayashi Y; ''Identification and characterization of human ethanolaminephosphotransferase1.''; J Lipid Res, 2007 PubMed Europe PMC Scholia
  195. Large WA, Saleh SN, Albert AP; ''Role of phosphoinositol 4,5-bisphosphate and diacylglycerol in regulating native TRPC channel proteins in vascular smooth muscle.''; Cell Calcium, 2009 PubMed Europe PMC Scholia
  196. Lacal JC; ''Choline kinase: a novel target for antitumor drugs.''; IDrugs, 2001 PubMed Europe PMC Scholia
  197. Sinha RK, Subrahmanyam G; ''Type II phosphatidylinositol 4-kinase(s) in cell signaling cascades.''; Indian J Biochem Biophys, 2007 PubMed Europe PMC Scholia
  198. Tsuboi K, Ikematsu N, Uyama T, Deutsch DG, Tokumura A, Ueda N; ''Biosynthetic pathways of bioactive N-acylethanolamines in brain.''; CNS Neurol Disord Drug Targets, 2013 PubMed Europe PMC Scholia
  199. Muzia TI, Kulikov VN; ''[1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine: acetylhydrolase is associated primarily with low density lipoproteins in human blood].''; Biokhimiia, 1991 PubMed Europe PMC Scholia
  200. Quest AF, Ghosh S, Xie WQ, Bell RM; ''DAG second messengers: molecular switches and growth control.''; Adv Exp Med Biol, 1997 PubMed Europe PMC Scholia
  201. Berdichevets IN, Tyazhelova TV, Shimshilashvili KhR, Rogaev EI; ''Lysophosphatidic acid is a lipid mediator with wide range of biological activities. Biosynthetic pathways and mechanism of action.''; Biochemistry (Mosc), 2010 PubMed Europe PMC Scholia
  202. Klingenberg M; ''Cardiolipin and mitochondrial carriers.''; Biochim Biophys Acta, 2009 PubMed Europe PMC Scholia
  203. Zhang Y, Du G; ''Phosphatidic acid signaling regulation of Ras superfamily of small guanosine triphosphatases.''; Biochim Biophys Acta, 2009 PubMed Europe PMC Scholia
  204. Lake BD; ''Histochemical demonstration of cytosolic alpha-glycerophosphate dehydrogenase (EC 1.1.1.8) and mitochondrial alpha-glycerophosphate dehydrogenase (EC 1.1.99.5).''; J Neurol Sci, 1987 PubMed Europe PMC Scholia
  205. Honda Z, Ishii S, Shimizu T; ''Platelet-activating factor receptor.''; J Biochem, 2002 PubMed Europe PMC Scholia
  206. Ward KB, Pattabiraman N; ''Comparative anatomy of phospholipase A2 structures.''; Adv Exp Med Biol, 1990 PubMed Europe PMC Scholia
  207. Brown AJ, Glish GL, McBay EH, Snyder F; ''Alkyldihydroxyacetonephosphate synthase mechanism: 18O studies of fatty acid release from acyldihydroxyacetone phosphate.''; Biochemistry, 1985 PubMed Europe PMC Scholia
  208. Leonardi R, Frank MW, Jackson PD, Rock CO, Jackowski S; ''Elimination of the CDP-ethanolamine pathway disrupts hepatic lipid homeostasis.''; J Biol Chem, 2009 PubMed Europe PMC Scholia
  209. Nikawa J, Yamashita S; ''Yeast mutant defective in synthesis of phosphatidylinositol. Isolation and characterization of a CDPdiacylglycerol--inositol 3-phosphatidyltransferase Km mutant.''; Eur J Biochem, 1982 PubMed Europe PMC Scholia
  210. Ridgway ND; ''The role of phosphatidylcholine and choline metabolites to cell proliferation and survival.''; Crit Rev Biochem Mol Biol, 2013 PubMed Europe PMC Scholia
  211. Thompson DH, Inerowicz HD, Grove J, Sarna T; ''Structural characterization of plasmenylcholine photooxidation products.''; Photochem Photobiol, 2003 PubMed Europe PMC Scholia
  212. Favrelière S, Barrier L, Durand G, Chalon S, Tallineau C; ''Chronic dietary n-3 polyunsaturated fatty acids deficiency affects the fatty acid composition of plasmenylethanolamine and phosphatidylethanolamine differently in rat frontal cortex, striatum, and cerebellum.''; Lipids, 1998 PubMed Europe PMC Scholia
  213. Paltauf F; ''Isolation of soluble proteins capable of stimulating aerobic plasmalogen biosynthesis.''; Eur J Biochem, 1978 PubMed Europe PMC Scholia
  214. Kawasaki K, Nishijima M; ''[Biosynthesis and function of phosphatidylglycerol and cardiolipin in animal cells].''; Tanpakushitsu Kakusan Koso, 1999 PubMed Europe PMC Scholia
  215. Zammit VA, Buckett LK, Turnbull AV, Wure H, Proven A; ''Diacylglycerol acyltransferases: Potential roles as pharmacological targets.''; Pharmacol Ther, 2008 PubMed Europe PMC Scholia
  216. Schug ZT, Gottlieb E; ''Cardiolipin acts as a mitochondrial signalling platform to launch apoptosis.''; Biochim Biophys Acta, 2009 PubMed Europe PMC Scholia
  217. Rock CO, Snyder F; ''Biosynthesis of 1-alkyl-sn-glycero-3-phosphate via adenosine triphosphate:1-alkyl-sn-glycerol phosphotransferase.''; J Biol Chem, 1974 PubMed Europe PMC Scholia
  218. Holmsen H, Hindenes JO, Fukami M; ''Glycerophospholipid metabolism: back to the future.''; Thromb Res, 1992 PubMed Europe PMC Scholia
  219. Arenth PM, Russell KC, Ricker JH, Zafonte RD; ''CDP-choline as a biological supplement during neurorecovery: a focused review.''; PM R, 2011 PubMed Europe PMC Scholia
  220. Jackowski S, Fagone P; ''CTP: Phosphocholine cytidylyltransferase: paving the way from gene to membrane.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
  221. Shenker BJ, Ali H, Boesze-Battaglia K; ''PIP3 regulation as promising targeted therapy of mast-cell-mediated diseases.''; Curr Pharm Des, 2011 PubMed Europe PMC Scholia
  222. Suh BC, Hille B; ''Regulation of ion channels by phosphatidylinositol 4,5-bisphosphate.''; Curr Opin Neurobiol, 2005 PubMed Europe PMC Scholia
  223. Henneberry AL, McMaster CR; ''Cloning and expression of a human choline/ethanolaminephosphotransferase: synthesis of phosphatidylcholine and phosphatidylethanolamine.''; Biochem J, 1999 PubMed Europe PMC Scholia
  224. Das AK, Milam JE, Reddy RC, Hajra AK; ''Facile syntheses of acyl dihydroxyacetone phosphates and lysophosphatidic acids having different acyl groups.''; J Lipid Res, 2006 PubMed Europe PMC Scholia
  225. Qiu Q, Liu G, Li W, Shi Q, Zhu F, Lu G; ''Glycerol-3-phosphate acyltransferase 4 gene is involved in mouse spermatogenesis.''; Acta Biochim Biophys Sin (Shanghai), 2009 PubMed Europe PMC Scholia
  226. Hajra AK, Das AK; ''Lipid biosynthesis in peroxisomes.''; Ann N Y Acad Sci, 1996 PubMed Europe PMC Scholia
  227. Glaser KB, Mobilio D, Chang JY, Senko N; ''Phospholipase A2 enzymes: regulation and inhibition.''; Trends Pharmacol Sci, 1993 PubMed Europe PMC Scholia
  228. Brown A, Snyder F; ''Alkyldihydroxyacetonephosphate synthase.''; Methods Enzymol, 1992 PubMed Europe PMC Scholia
  229. Waku K, Sugiura T, Nakagawa Y; ''Metabolism of 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine: a precursor of platelet-activating factor in macrophages.''; Adv Prostaglandin Thromboxane Leukot Res, 1985 PubMed Europe PMC Scholia
  230. Salamon RS, Backer JM; ''Phosphatidylinositol-3,4,5-trisphosphate: Tool of choice for class I PI 3-kinases.''; Bioessays, 2013 PubMed Europe PMC Scholia
  231. Rabert U, Völkl A, Debuch H; ''Distribution of alkylglycerone-phosphate synthase in subcellular fractions of rat liver.''; Biol Chem Hoppe Seyler, 1986 PubMed Europe PMC Scholia
  232. Hosaka K, Schiele U, Numa S; ''Diacylglycerol acyltransferase from rat liver microsomes. Separation and acyl-donor specificity.''; Eur J Biochem, 1977 PubMed Europe PMC Scholia
  233. Vance JE; ''Molecular and cell biology of phosphatidylserine and phosphatidylethanolamine metabolism.''; Prog Nucleic Acid Res Mol Biol, 2003 PubMed Europe PMC Scholia
  234. Yamashita S, Hosaka K, Miki Y, Numa S; ''Glycerolipid acyltransferases from rat liver: 1-acylglycerophosphate acyltransferase, 1-acylglycerophosphorylcholine acyltransferase, and diacylglycerol acyltransferase.''; Methods Enzymol, 1981 PubMed Europe PMC Scholia
  235. Shindou H, Hishikawa D, Nakanishi H, Harayama T, Ishii S, Taguchi R, Shimizu T; ''A single enzyme catalyzes both platelet-activating factor production and membrane biogenesis of inflammatory cells. Cloning and characterization of acetyl-CoA:LYSO-PAF acetyltransferase.''; J Biol Chem, 2007 PubMed Europe PMC Scholia
  236. Carman GM, Kelley MJ; ''CDPdiacylglycerol synthase from yeast.''; Methods Enzymol, 1992 PubMed Europe PMC Scholia
  237. Yang CY, Frohman MA; ''Mitochondria: signaling with phosphatidic acid.''; Int J Biochem Cell Biol, 2012 PubMed Europe PMC Scholia
  238. Verheij HM, Slotboom AJ, de Haas GH; ''Structure and function of phospholipase A2.''; Rev Physiol Biochem Pharmacol, 1981 PubMed Europe PMC Scholia
  239. Biermann J, Just WW, Wanders RJ, Van Den Bosch H; ''Alkyl-dihydroxyacetone phosphate synthase and dihydroxyacetone phosphate acyltransferase form a protein complex in peroxisomes.''; Eur J Biochem, 1999 PubMed Europe PMC Scholia
  240. André A, Tessier C, Brétillon L, Sébédio JL, Chardigny JM; ''In situ hybridization of dihydroxyacetone phosphate acyltransferase, the regulating enzyme involved in plasmalogen biosynthesis.''; Brain Res Mol Brain Res, 2005 PubMed Europe PMC Scholia
  241. Mrá�ek T, Drahota Z, Houštěk J; ''The function and the role of the mitochondrial glycerol-3-phosphate dehydrogenase in mammalian tissues.''; Biochim Biophys Acta, 2013 PubMed Europe PMC Scholia
  242. Mavis RD, Vang MJ; ''Optimal assay and subcellular location of phosphatidylglycerol synthesis in lung.''; Biochim Biophys Acta, 1981 PubMed Europe PMC Scholia
  243. Mancini A, Roberti R, Binaglia L, el Missiri A, Freysz L; ''Factors affecting the stability of detergent-solubilized cholinephosphotransferase and ethanolaminephosphotransferase.''; Membr Biochem, 1993 PubMed Europe PMC Scholia
  244. van den Bosch H, de Vet EC; ''Alkyl-dihydroxyacetonephosphate synthase.''; Biochim Biophys Acta, 1997 PubMed Europe PMC Scholia
  245. Dobrowsky RT, Ballas LM; ''Peroxisomal dihydroxyacetone phosphate acyltransferase. Effect of acetaldehyde on the intact and solubilized activity.''; J Biol Chem, 1987 PubMed Europe PMC Scholia
  246. Scherer M, Schmitz G; ''Metabolism, function and mass spectrometric analysis of bis(monoacylglycero)phosphate and cardiolipin.''; Chem Phys Lipids, 2011 PubMed Europe PMC Scholia
  247. Ohtsuka J, Nagata K, Lee WC, Ono Y, Fukuda R, Ohta A, Tanokura M; ''Crystallization and preliminary X-ray analysis of CTP:phosphoethanolamine cytidylyltransferase (ECT) from Saccharomyces cerevisiae.''; Acta Crystallogr Sect F Struct Biol Cryst Commun, 2006 PubMed Europe PMC Scholia
  248. Blank ML, Lee YJ, Cress EA, Snyder F; ''Stimulation of the de novo pathway for the biosynthesis of platelet-activating factor (PAF) via cytidylyltransferase activation in cells with minimal endogenous PAF production.''; J Biol Chem, 1988 PubMed Europe PMC Scholia
  249. Nakashima A, Hosaka K, Nikawa J; ''Cloning of a human cDNA for CTP-phosphoethanolamine cytidylyltransferase by complementation in vivo of a yeast mutant.''; J Biol Chem, 1997 PubMed Europe PMC Scholia
  250. Kumaran D, Bonanno JB, Burley SK, Swaminathan S; ''Crystal structure of phosphatidylglycerophosphatase (PGPase), a putative membrane-bound lipid phosphatase, reveals a novel binuclear metal binding site and two "proton wires".''; Proteins, 2006 PubMed Europe PMC Scholia
  251. Wright MM, McMaster CR; ''PC and PE synthesis: mixed micellar analysis of the cholinephosphotransferase and ethanolaminephosphotransferase activities of human choline/ethanolamine phosphotransferase 1 (CEPT1).''; Lipids, 2002 PubMed Europe PMC Scholia
  252. Frentzen M; ''Phosphatidylglycerol and sulfoquinovosyldiacylglycerol: anionic membrane lipids and phosphate regulation.''; Curr Opin Plant Biol, 2004 PubMed Europe PMC Scholia
  253. Huang CL; ''Complex roles of PIP2 in the regulation of ion channels and transporters.''; Am J Physiol Renal Physiol, 2007 PubMed Europe PMC Scholia
  254. Tie A, Bakovic M; ''Alternative splicing of CTP:phosphoethanolamine cytidylyltransferase produces two isoforms that differ in catalytic properties.''; J Lipid Res, 2007 PubMed Europe PMC Scholia
  255. Chang J, Musser JH, McGregor H; ''Phospholipase A2: function and pharmacological regulation.''; Biochem Pharmacol, 1987 PubMed Europe PMC Scholia
  256. Moolenaar WH, van Meeteren LA, Giepmans BN; ''The ins and outs of lysophosphatidic acid signaling.''; Bioessays, 2004 PubMed Europe PMC Scholia
  257. Saulnier-Blache JS; ''[Lysophosphatidic acid: a "bioactive" phospholipid].''; Med Sci (Paris), 2004 PubMed Europe PMC Scholia
  258. Claypool SM; ''Cardiolipin, a critical determinant of mitochondrial carrier protein assembly and function.''; Biochim Biophys Acta, 2009 PubMed Europe PMC Scholia
  259. Baker RR; ''Lipid acetylation reactions and the metabolism of platelet-activating factor.''; Neurochem Res, 2000 PubMed Europe PMC Scholia
  260. Stremmel W, Ehehalt R, Staffer S, Stoffels S, Mohr A, Karner M, Braun A; ''Mucosal protection by phosphatidylcholine.''; Dig Dis, 2012 PubMed Europe PMC Scholia
  261. Secades JJ, Frontera G; ''CDP-choline: pharmacological and clinical review.''; Methods Find Exp Clin Pharmacol, 1995 PubMed Europe PMC Scholia
  262. Downes P, Michell RH; ''Phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate: lipids in search of a function.''; Cell Calcium, 1982 PubMed Europe PMC Scholia
  263. Ide H, Miller JC, Weinhold PA; ''Ethanolaminephosphotransferase in rat lung: selectivity for endogenous and exogenous diacylglycerol.''; Biochim Biophys Acta, 1988 PubMed Europe PMC Scholia
  264. Kent C; ''CTP:phosphocholine cytidylyltransferase.''; Biochim Biophys Acta, 1997 PubMed Europe PMC Scholia
  265. Yin H, Zhu M; ''Free radical oxidation of cardiolipin: chemical mechanisms, detection and implication in apoptosis, mitochondrial dysfunction and human diseases.''; Free Radic Res, 2012 PubMed Europe PMC Scholia
  266. Aoki J, Inoue A, Okudaira S; ''Two pathways for lysophosphatidic acid production.''; Biochim Biophys Acta, 2008 PubMed Europe PMC Scholia
  267. Vance DE, Walkey CJ, Cui Z; ''Phosphatidylethanolamine N-methyltransferase from liver.''; Biochim Biophys Acta, 1997 PubMed Europe PMC Scholia
  268. Baker RR; ''Enzymes of platelet activating factor synthesis in brain.''; Neurochem Res, 1995 PubMed Europe PMC Scholia
  269. Hammond LE, Neschen S, Romanelli AJ, Cline GW, Ilkayeva OR, Shulman GI, Muoio DM, Coleman RA; ''Mitochondrial glycerol-3-phosphate acyltransferase-1 is essential in liver for the metabolism of excess acyl-CoAs.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
  270. Bobenchik AM, Augagneur Y, Hao B, Hoch JC, Ben Mamoun C; ''Phosphoethanolamine methyltransferases in phosphocholine biosynthesis: functions and potential for antiparasite therapy.''; FEMS Microbiol Rev, 2011 PubMed Europe PMC Scholia
  271. Janardhan S, Srivani P, Sastry GN; ''Choline kinase: an important target for cancer.''; Curr Med Chem, 2006 PubMed Europe PMC Scholia
  272. Rüstow B, Kunze D; ''Diacylglycerol synthesized in vitro from sn-glycerol 3-phosphate and the endogenous diacylglycerol are different substrate pools for the biosynthesis of phosphatidylcholine in rat lung microsomes.''; Biochim Biophys Acta, 1985 PubMed Europe PMC Scholia
  273. Snyder F; ''Alkylglycerol phosphotransferase.''; Methods Enzymol, 1992 PubMed Europe PMC Scholia
  274. Vance JE, Tasseva G; ''Formation and function of phosphatidylserine and phosphatidylethanolamine in mammalian cells.''; Biochim Biophys Acta, 2013 PubMed Europe PMC Scholia
  275. Blank ML, Spector AA, Kaduce TL, Lee TC, Snyder F; ''Metabolism of platelet activating factor (1-alkyl-2-acetyl-sn-glycero-3-phosphocholine) and 1-alkyl-2-acetyl-sn-glycerol by human endothelial cells.''; Biochim Biophys Acta, 1986 PubMed Europe PMC Scholia
  276. Nikawa J, Yamashita S; ''Phosphatidylinositol synthase from yeast.''; Biochim Biophys Acta, 1997 PubMed Europe PMC Scholia
  277. Macfarlane MG; ''Phosphatidylglycerols and lipoamino acids.''; Adv Lipid Res, 1964 PubMed Europe PMC Scholia
  278. Nakagawa Y, Waku K; ''The metabolism of glycerophospholipid and its regulation in monocytes and macrophages.''; Prog Lipid Res, 1989 PubMed Europe PMC Scholia
  279. Snyder F, Blank M, Lee TC, Robinson M, Woodard D; ''Measurement of key enzyme activities involved in the metabolism of platelet activating factor.''; Methods Enzymol, 1987 PubMed Europe PMC Scholia
  280. Cabezas MC, Erkelens DW; ''Triglycerides and atherosclerosis: to feast or fast.''; Neth J Med, 2000 PubMed Europe PMC Scholia
  281. Pascual F, Carman GM; ''Phosphatidate phosphatase, a key regulator of lipid homeostasis.''; Biochim Biophys Acta, 2013 PubMed Europe PMC Scholia
  282. Rosonina E, Manley JL; ''From transcription to mRNA: PAF provides a new path.''; Mol Cell, 2005 PubMed Europe PMC Scholia
  283. Ofman R, Hogenhout EM, Wanders RJ; ''Identification and characterization of the mouse cDNA encoding acyl-CoA:dihydroxyacetone phosphate acyltransferase.''; Biochim Biophys Acta, 1999 PubMed Europe PMC Scholia
  284. Gibellini F, Smith TK; ''The Kennedy pathway--De novo synthesis of phosphatidylethanolamine and phosphatidylcholine.''; IUBMB Life, 2010 PubMed Europe PMC Scholia
  285. Lewis RN, McElhaney RN; ''The physicochemical properties of cardiolipin bilayers and cardiolipin-containing lipid membranes.''; Biochim Biophys Acta, 2009 PubMed Europe PMC Scholia
  286. Paoletti L, Elena C, Domizi P, Banchio C; ''Role of phosphatidylcholine during neuronal differentiation.''; IUBMB Life, 2011 PubMed Europe PMC Scholia
  287. Francescangeli E, Goracci G; ''The de novo biosynthesis of platelet-activating factor in rat brain.''; Biochem Biophys Res Commun, 1989 PubMed Europe PMC Scholia
  288. Wu G, Vance DE; ''Choline kinase and its function.''; Biochem Cell Biol, 2010 PubMed Europe PMC Scholia
  289. Montero J, Mari M, Colell A, Morales A, Basañez G, Garcia-Ruiz C, Fernández-Checa JC; ''Cholesterol and peroxidized cardiolipin in mitochondrial membrane properties, permeabilization and cell death.''; Biochim Biophys Acta, 2010 PubMed Europe PMC Scholia
  290. Rauchová H, Drahota Z; ''Inhibition of the glycerol 3-phosphate oxidation by free fatty acids.''; Int J Biochem, 1984 PubMed Europe PMC Scholia
  291. Sugimoto H, Banchio C, Vance DE; ''Transcriptional regulation of phosphatidylcholine biosynthesis.''; Prog Lipid Res, 2008 PubMed Europe PMC Scholia
  292. Mott GE, Brinkley AW; ''Plasmenylethanolamine: growth factor for cholesterol-reducing Eubacterium.''; J Bacteriol, 1979 PubMed Europe PMC Scholia
  293. Meyers RE, Cantley LC; ''Phosphatidylinositol 4-kinases. Assays and product analysis.''; Methods Mol Biol, 1998 PubMed Europe PMC Scholia
  294. Ishidate K, Matsuo R, Nakazawa Y; ''CDPcholine:1,2-diacylglycerol cholinephosphotransferase from rat liver microsomes. I. Solubilization and characterization of the partially purified enzyme and the possible existence of an endogenous inhibitor.''; Lipids, 1993 PubMed Europe PMC Scholia
  295. Gupta CM, Radhakrishnan R, Khorana HG; ''Glycerophospholipid synthesis: improved general method and new analogs containing photoactivable groups.''; Proc Natl Acad Sci U S A, 1977 PubMed Europe PMC Scholia
  296. Lee TC, Malone B, Blank ML, Fitzgerald V, Snyder F; ''Regulation of the synthesis of platelet-activating factor and its inactive storage precursor (1-alkyl-2-acyl-sn-glycero-3-phosphocholine) from 1-alkyl-2-acetyl-sn-glycerol by rabbit platelets.''; J Biol Chem, 1990 PubMed Europe PMC Scholia
  297. Idahl LA, Lembert N; ''Glycerol 3-phosphate-induced ATP production in intact mitochondria from pancreatic B-cells.''; Biochem J, 1995 PubMed Europe PMC Scholia
  298. Kannan L, Knudsen J, Jolly CA; ''Aging and acyl-CoA binding protein alter mitochondrial glycerol-3-phosphate acyltransferase activity.''; Biochim Biophys Acta, 2003 PubMed Europe PMC Scholia
  299. van den Bout I, Divecha N; ''PIP5K-driven PtdIns(4,5)P2 synthesis: regulation and cellular functions.''; J Cell Sci, 2009 PubMed Europe PMC Scholia
  300. Hartz CS, Schalinske KL; ''Phosphatidylethanolamine N-methyltransferase and regulation of homocysteine.''; Nutr Rev, 2006 PubMed Europe PMC Scholia
  301. Ueda H, Matsunaga H, Olaposi OI, Nagai J; ''Lysophosphatidic acid: chemical signature of neuropathic pain.''; Biochim Biophys Acta, 2013 PubMed Europe PMC Scholia
  302. Hartvigsen K, Ravandi A, Harkewicz R, Kamido H, Bukhave K, Hølmera G, Kuksis A; ''1 -O-alkyl-2-(omega-oxo)acyl-sn-glycerols from shark oil and human milk fat are potential precursors of PAF mimics and GHB.''; Lipids, 2006 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
126497view18:52, 10 May 2023KhanspersAdded lit ref and xref to Shark Liver Oil
124384view05:54, 24 October 2022EgonwTyped three metabolites
120261view13:40, 22 November 2021Conroy lipidsadded some DB crossrefs
117145view09:41, 18 May 2021EweitzModified title
113857view06:37, 2 December 2020EgonwReplaced a deleted PubMed identifier with the (working) duplicate
110695view13:58, 28 May 2020L DupuisUpdated Chebi identifiers
110693view13:50, 28 May 2020L DupuisCHeBi ID added for inorganic phosphate
107760view16:15, 1 November 2019DeSlOntology Term : 'phosphatidylcholine metabolic pathway' added !
107759view16:14, 1 November 2019DeSlOntology Term : 'phosphoinositide metabolic pathway' added !
107758view16:12, 1 November 2019DeSlOntology Term : 'PW:0001156' removed !
107757view16:11, 1 November 2019DeSlUpdated all curved lines for side metabolites to MIMconversion pointing to/away from anchor.
107756view15:48, 1 November 2019DeSlUpdated IDs for EC 2.7.1.153 (bottom right corner).
107755view09:55, 1 November 2019DeSlUpdated top half of PW, so side metabolites are connected to anchors.
107754view09:49, 1 November 2019DeSlAdded separate IDs for proteins under EC 2.3.1.15 .
107753view09:31, 1 November 2019DeSlChanged 2- to "1-" in 1-acyl-sn-glycero-3-phosphate (Lysophosphatidic acid; LPA) (reaction otherwise doesn't occure in humans.
107133view14:21, 17 September 2019MaintBotChEBI identifier normalization
106718view13:15, 17 September 2019MaintBotHMDB identifier normalization
106449view11:34, 29 August 2019DeSlUpdated LipidMaps ID for TAG.
105333view12:05, 31 July 2019EgonwThe class, not the reference lipid.
98235view12:32, 14 August 2018EgonwReplace a PubChem SID with a ChEBI ID.
98103view11:11, 20 July 2018DeSlOntology Term : 'glycerophospholipid metabolic pathway' added !
95594view14:18, 5 January 2018DeSlChanged part of the layout for readability of this pathway.
93096view15:17, 28 July 2017DeSlChanged all the PubChem Substance ID's (around 13) to more stereospecific IDs.
93077view08:52, 28 July 2017ElisaFixed unconnected lines and changed arrows in the legend from interactions to graphical elements
93029view16:02, 26 July 2017DeSlChanged hydrate ID from PubChem compounds to correct HMDB ID for D-glucose-6-P
92861view15:19, 10 July 2017EgonwFixed PubChem compound ID (was salt, now pure compound).
85647view17:10, 4 June 2016EgonwFixed the PubChem SID.
84117view10:00, 16 January 2016EgonwFixed a typo in the label.
83825view11:17, 14 December 2015EgonwRemoved data source info from identifiers.
76320view07:17, 2 July 2014Mkutmonadded chebi identifiers to metabolites annotated with GO terms
71989view11:13, 24 October 2013MkutmonChanged Unknown -> Metabolite for 3 (S-adenosyl-methionine) and 3 (S-adenosylhomocysteine)
71699view19:49, 17 October 2013MaintBotUpdated data sources
70448view22:31, 1 August 2013AmanzoPeriodical save, work in progress
70447view22:21, 1 August 2013AmanzoPeriodical save, work in progress
70404view16:13, 29 July 2013AmanzoWork in progress
70403view16:07, 29 July 2013AmanzoPeriodical save, work in progress
70390view16:04, 26 July 2013AmanzoPeriodical save, work in progress
70389view23:52, 25 July 2013AmanzoWork in progress
70388view23:42, 25 July 2013AmanzoPeriodical save, work in progress
70387view23:32, 25 July 2013AmanzoPeriodical save, work in progress
70384view17:34, 23 July 2013AmanzoWork in progress
70381view23:33, 21 July 2013AmanzoPeriodical save, work in progress
70380view23:22, 21 July 2013AmanzoPeriodical save, work in progress
70379view23:12, 21 July 2013AmanzoPeriodical save, work in progress
70378view23:02, 21 July 2013AmanzoPeriodical save, work in progress
70377view22:52, 21 July 2013AmanzoPeriodical save, work in progress
70376view22:42, 21 July 2013AmanzoPeriodical save, work in progress
70375view22:32, 21 July 2013AmanzoPeriodical save, work in progress
70374view22:21, 21 July 2013AmanzoPeriodical save, work in progress
70373view22:11, 21 July 2013AmanzoPeriodical save, work in progress

External references

DataNodes

View all...
NameTypeDatabase referenceComment
1,2-diacyl-sn-glycero-3-cytidine-5'-diphosphate (CDP-DAG, CMP-PA)MetaboliteLMGP13010000 (LIPID MAPS)
1,2-diacyl-sn-glycero-3-phosphate (Phosphatidic acid; PA)MetaboliteLMGP10010000 (LIPID MAPS)
1,2-diacyl-sn-glycero-3-phospho-(1'-myo-inositol) (PI)MetaboliteLMGP06010000 (LIPID MAPS)
1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-phosphate) (PGP)
1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) (PG)MetaboliteLMGP04010000 (LIPID MAPS)
1,2-diacyl-sn-glycero-3-phosphocholine (PC, Lecithin)MetaboliteLMGP01010000 (LIPID MAPS)
1,2-diacyl-sn-glycero-3-phosphoethanolamine (PE)MetaboliteLMGP02010000 (LIPID MAPS)
1,2-diacyl-sn-glycero-3-phosphoserine (PS)MetaboliteLMGP03010000 (LIPID MAPS)
1,2-diacyl-sn-glycerol (1,2-diacylglycerol; 1,2-DAG)MetaboliteLMGL02010000 (LIPID MAPS)
1-phosphatidylinositol 4-kinase EC 2.7.1.67ProteinQ9BTU6 (Uniprot/TrEMBL)
1-phosphatidylinositol 4-phosphate 5-kinase EC 2.7.1.68ProteinQ99755 (Uniprot/TrEMBL)
1D-myo-Inositol-1-PMetaboliteCID 5288642 (PubChem-compound)
2-acyl-sn-glycero-3-phosphate (Lysophosphatidic acid; LPA)MetaboliteLMGP10050000 (LIPID MAPS)
2-acylglycerol-3-phosphate O-acyltransferase EC 2.3.1.52ProteinEC 2.3.1.52 (Enzyme Nomenclature)
3 (S-adenosyl-methionine)CID 34756 (PubChem-compound)
3 (S-adenosylhomocysteine)CID 439155 (PubChem-compound)
ADPMetaboliteCID 6022 (PubChem-compound)
ATPMetaboliteCID 5957 (PubChem-compound)
Acyl coenzyme A (Acyl-CoA)MetaboliteSID 3342 (PubChem-substance)
Acyl-CoAMetaboliteSID 3342 (PubChem-substance)
Adenosine diphosphate (ADP)MetaboliteCID 6022 (PubChem-compound)
Adenosine triphosphate (ATP)MetaboliteCID 5957 (PubChem-compound)
CDP-DAGMetaboliteLMGP13010000 (LIPID MAPS)
CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase EC 2.7.8.5ProteinQ32NB8 (Uniprot/TrEMBL)
CDP-diacylglyreol-inositol 3-phosphatidyltransferase EC 2.7.8.11ProteinO14735 (Uniprot/TrEMBL)
CMPMetaboliteCID 6131 (PubChem-compound)
CTPMetaboliteCID 6176 (PubChem-compound)
Cardiolipin (DPG, CL)MetaboliteLMPG12010000 (LIPID MAPS)
Cardiolipin synthase EC 2.7.8.-ProteinQ9UJA2 (Uniprot/TrEMBL)
Choline kinase EC 2.7.1.32ProteinQ9Y259 (Uniprot/TrEMBL)
Choline-phosphate cytidylyltransferase EC 2.7.7.15ProteinQ9Y259 (Uniprot/TrEMBL)
CholineMetaboliteCID 305 (PubChem-substance)
CoA-SHMetaboliteCID 6816 (PubChem-compound)
Coenzyme A (CoA-SH)MetaboliteCID 6816 (PubChem-compound)
Cytidine diphosphate choline (CDP-choline)MetaboliteCID 25202509 (PubChem-compound)
Cytidine diphosphate ethanolamine (CDP-ethanolamine)MetaboliteCID 123727 (PubChem-compound)
Cytidine monophosphate (CMP)MetaboliteCID 6131 (PubChem-compound)
Cytidine triphosphate (CTP)MetaboliteCID 6176 (PubChem-compound)
D-Glucose-6-PMetaboliteCID 44134741 (PubChem-compound)
Diacylglycerol O-acyltransferase EC 2.3.1.20ProteinQ86VF5 (Uniprot/TrEMBL)
Diacylglycerol cholinephosphotransferase EC 2.7.8.2ProteinQ8WUD6 (Uniprot/TrEMBL)
Dihydroxyacetone phosphateMetaboliteCID 668 (PubChem-compound)
Ethanolamine kinase EC 2.7.1.82ProteinQ9Y259 (Uniprot/TrEMBL)
Ethanolamine-phosphate cytidylyltransferase EC 2.7.7.14ProteinQ99447 (Uniprot/TrEMBL)
EthanolamineMetaboliteCID 700 (PubChem-compound)
Ethanolaminephosphotransferase EC 2.7.8.1ProteinQ9Y6K0 (Uniprot/TrEMBL)
Fatty acid MetabolismPathway00071 (KEGG Pathway)
GlucoseMetabolite
Glycerol kinase EC 2.7.1.30ProteinP32189 (Uniprot/TrEMBL)
Glycerol-3-PMetaboliteCID 7048686 (PubChem-compound)
Glycerol-3-phosphate 2-O-acyltransferase EC 2.3.1.198ProteinO80437 (Uniprot/TrEMBL)
Glycerol-3-phosphate dehydrogenase (NAD+) EC 1.1.1.8ProteinP21695 (Uniprot/TrEMBL)
GlycerolMetaboliteCID 753 (PubChem-compound)
GlycolysisPathway00010 (KEGG Pathway)
H2O
InositolMetaboliteCID 892 (PubChem-compound)
L-serine-phosphatidylethanolamine phosphatidyltransferase EC 2.7.8.29ProteinP48651 (Uniprot/TrEMBL)
NAD+ (Coenzyme I)MetaboliteCID 5892 (PubChem-compound)
NADH + H+MetaboliteCID 439153 (PubChem-compound)
PIP2[4',5']MetaboliteLMGP08010003 (LIPID MAPS)
PIP3[3',4',5']MetaboliteLMGP09010001 (LIPID MAPS)
PPiMetabolite
Phosphatidate cytidylyltransferase EC 2.7.7.41ProteinO95674 (Uniprot/TrEMBL)
Phosphatidate phosphatase EC 3.1.3.4ProteinQ14693 (Uniprot/TrEMBL)
Phosphatidylethanolamine N-methyltransferase EC 2.1.1.17ProteinQ9UBM1 (Uniprot/TrEMBL)
Phosphatidylglycerophosphatase EC 3.1.3.27ProteinQ8WUK0 (Uniprot/TrEMBL)
Phosphatidylinositol-4,5-bisphosphate 3-kinase EC 2.7.1.153ProteinQ42338 (Uniprot/TrEMBL)
Phosphatidylinositol-4-phosphate (PIP)MetaboliteLMGP07010003 (LIPID MAPS)
Phosphocholine (Choline-P)MetaboliteCID 1014 (PubChem-compound)
PhosphorylethanolamineMetaboliteCID 1015 (PubChem-compound)
PiMetabolite
Pyrimidine MetabolismPathway00240 (KEGG Pathway)
SerineMetaboliteCID 5951 (PubChem-compound)
sn-glycerol-3-phosphate (glycerol-3-P)MetaboliteCID 7048686 (PubChem-compound)
triacyl-sn-glycerol (Triacylglycerol; TAG)MetaboliteLMGL03010000 (LIPID MAPS)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP2533"
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