daf-2 or insulin signaling pathway (Caenorhabditis elegans)

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Description

Insulin receptor pathway in C. elegans Initial version based on review by Gami and Wolkow of pathways that affect ageing.

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Ontology Terms

Bibliography

Gami MS, Wolkow CA; ''Studies of Caenorhabditis elegans DAF-2/insulin signaling reveal targets for pharmacological manipulation of lifespan.''; Aging Cell, 2006 PubMed Europe PMC Scholia

History

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Revision	Action	Time	User	Comment
137452	view	13:11, 2 March 2025	Egonw	Modified description
135383	view	08:12, 3 September 2024	Egonw	Converted to use Ensembl identifiers
106023	view	11:54, 16 August 2019	MaintBot	HMDB identifier normalization
102297	view	19:34, 17 December 2018	Khanspers	Modified description
102296	view	19:34, 17 December 2018	Khanspers	fixed unconnected
96588	view	18:11, 22 March 2018	Asios Olia	Modified description
96587	view	18:10, 22 March 2018	Asios Olia	Modified description
72339	view	22:07, 8 November 2013	Kyook	Ontology Term : 'insulin-like growth factor signaling pathway' added !
70500	view	00:19, 8 August 2013	Cgrove	Connecting lines
70499	view	00:17, 8 August 2013	Cgrove	Connected lines
68474	view	20:37, 5 July 2013	MaintBot	Updated to 2013 gpml schema
67143	view	10:12, 26 June 2013	Christine Chichester	Ontology Term : 'aging pathway' added !
40626	view	19:57, 1 March 2011	MaintBot	Removed redundant pathway information and comments
32939	view	06:17, 24 September 2009	Pieter Giesbertz	Connected lines
32817	view	13:34, 9 September 2009	Pieter Giesbertz	Updated title
31983	view	13:12, 14 August 2009	MaintBot	Fixed group labels
29668	view	16:07, 25 May 2009	MartijnVanIersel	Annotated node
28739	view	12:27, 2 March 2009	MartijnVanIersel	Corrected identifiers
20709	view	11:29, 14 November 2008	MaintBot	[[Pathway:Caenorhabditis elegans:daf-2 or insuling signaling pathway]] moved to [[Pathway:WP17]]: Moved to stable identifier
11859	view	09:16, 7 May 2008	MartijnVanIersel	Modified categories
10674	view	12:51, 21 February 2008	MartijnVanIersel	added annotation for all genes
10669	view	12:45, 21 February 2008	MartijnVanIersel	Modified description
10666	view	12:43, 21 February 2008	MartijnVanIersel	Specify description
10665	view	12:41, 21 February 2008	MartijnVanIersel	labels
10664	view	12:39, 21 February 2008	MartijnVanIersel	added connectors
10662	view	12:31, 21 February 2008	MartijnVanIersel	added main genes
10659	view	12:29, 21 February 2008	MartijnVanIersel	first version

External references

DataNodes

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Name	Type	Database reference
AGE-1/PI-3K	GeneProduct	B0334.8 (WormBase)
AKT-1	GeneProduct	C12D8.10 (WormBase)
AKT-2	GeneProduct	F28H6.1 (WormBase)
DAF-16/FOXO	GeneProduct	R13H8.1 (WormBase)
DAF-18/PTEN	GeneProduct	T07A9.6 (WormBase)
DAF-2/INSR	GeneProduct	Y55D5A.5 (WormBase)
PDK-1	GeneProduct	H42K12.1 (WormBase)
PIP	Metabolite	HMDB04249 (HMDB)
SGK-1	GeneProduct	W10G6.2 (WormBase)