daf-2 or insulin signaling pathway (Caenorhabditis elegans)
From WikiPathways
Description
Insulin receptor pathway in C. elegans
Initial version based on review by Gami and Wolkow of pathways that affect ageing.
Quality Tags
Ontology Terms
Pathway Ontology : disease pathway
Disease : congenital heart disease oculocerebrorenal syndrome male infertility juvenile myoclonic epilepsy Senior-Loken syndrome Pallister-Hall syndrome Bardet-Biedl syndrome sensorineural hearing loss Carpenter syndrome hydrolethalus syndrome cone-rod dystrophy asphyxiating thoracic dystrophy holoprosencephaly nephronophthisis orofaciodigital syndrome infertility ciliopathy retinitis pigmentosa Leber congenital amaurosis Greig cephalopolysyndactyly syndrome primary ciliary dyskinesia Meckel syndrome Ellis-Van Creveld syndrome medulloblastoma lethal congenital contracture syndrome Birt-Hogg-Dube syndrome polycystic kidney disease Joubert syndrome
Bibliography
- Gami MS, Wolkow CA; ''Studies of Caenorhabditis elegans DAF-2/insulin signaling reveal targets for pharmacological manipulation of lifespan.''; Aging Cell, 2006 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name ![]() | Type ![]() | Database reference ![]() | Comment ![]() |
---|---|---|---|
AGE-1/PI-3K | GeneProduct | B0334.8 (WormBase) ![]() | |
AKT-1 | GeneProduct | C12D8.10 (WormBase) ![]() | |
AKT-2 | GeneProduct | F28H6.1 (WormBase) ![]() | |
DAF-16/FOXO | GeneProduct | R13H8.1 (WormBase) ![]() | |
DAF-18/PTEN | GeneProduct | T07A9.6 (WormBase) ![]() | |
DAF-2/INSR | GeneProduct | Y55D5A.5 (WormBase) ![]() | |
PDK-1 | GeneProduct | H42K12.1 (WormBase) ![]() | |
PIP | Metabolite | HMDB04249 (HMDB) ![]() | |
SGK-1 | GeneProduct | W10G6.2 (WormBase) ![]() |
Annotated Interactions
No annotated interactions