Butyrate-induced histone acetylation (Homo sapiens)

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1Acetyl CoAGlucoseLipidbiosynthesisAcetylated HistoneBeta oxidationTCAcycleCitrateButyrateACLAKTButyrateCitrateHDACsAcetyl CoAButyrate


Description

Metabolism of butyrate is suggested to be an energy source for histone acetylation.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Davie JR; ''Inhibition of histone deacetylase activity by butyrate.''; J Nutr, 2003 PubMed Europe PMC Scholia
  2. Donohoe DR, Collins LB, Wali A, Bigler R, Sun W, Bultman SJ; ''The Warburg Effect Dictates the Mechanism of Butyrate-Mediated Histone Acetylation and Cell Proliferation.''; Mol Cell, 2012 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
123102view08:57, 3 July 2022EgonwMade two pathways clickable
105116view13:51, 8 July 2019DeSlChanged ID for HDACs from Wikidata to InterPro
102201view14:53, 9 December 2018EgonwReplaced Wikipedia with Wikidata identifiers.
89148view21:58, 22 August 2016AriuttaOntology Term : 'classic metabolic pathway' added !
88590view19:35, 11 August 2016Mkutmonfix unconnected lines
73980view11:32, 13 March 2014MaintBotClarified what inhibits the HDACs.
73979view11:30, 13 March 2014MaintBot
73978view11:23, 13 March 2014MaintBotConverted 'beta oxidaton' to a label.
73977view11:14, 13 March 2014MaintBot
73976view11:09, 13 March 2014MaintBotMore identifiers.
73975view11:02, 13 March 2014MaintBotMore identifiers and fixed AKT and ACL to be protein.
73974view10:58, 13 March 2014MaintBotUsed ChEBI instead of InChIs (for now)
73973view10:47, 13 March 2014MaintBotModified description
69937view20:01, 11 July 2013Mkutmonfixed unconnected lines
69009view17:46, 8 July 2013MaintBotUpdated to 2013 gpml schema
57918view20:38, 4 February 2013MaintBotModified categories
54005view10:13, 18 November 2012EgonwCompleted the diagram
54004view09:59, 18 November 2012EgonwEnsured all translocations are now MIM conversions (as suggested on the ML).
53994view19:16, 17 November 2012Egonw
53993view18:03, 17 November 2012EgonwAdded InChIs.
53933view13:23, 16 November 2012EgonwAdded reference and several interactions
53932view13:15, 16 November 2012EgonwAdded the core metabolites
53931view13:01, 16 November 2012EgonwNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACLMetabolite
AKTMetabolite
Acetyl CoAMetaboliteInChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/t13-,16-,17-,18+,22-/m1/s1 (InChI)
Acetylated HistoneComplex
Beta oxidation
ButyrateMetaboliteCHEBI:17968 (ChEBI)
CitrateMetaboliteCHEBI:35808 (ChEBI)
GlucoseMetaboliteCHEBI:17634 (ChEBI)
HDACs
Lipid biosynthesisPathway
TCA cyclePathway

Annotated Interactions

No annotated interactions

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