FAS pathway and stress induction of HSP regulation (Gallus gallus)

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1Self-activationStressCytoplasmApoptosome3x-PROSInhibition3x-PMitochondria PathwayNFK-B PathwayNucleusNecrosisCutFAS PathwayCell SurvivalExtracellularActivateDNA presentation3x-PStress Induction of HSP regulationProteasomeApoptosisCASP3CASP8FADDPhosphateDAXXCASP8PhosphateARHGDIBLMNB1FAF1CFLARMAP3K7JUNCASP7MAPKAPK3PhosphateHSPB1LMNB2FASDAXXDFFBIL1ACYCSPhosphateFAP1HSPB1CASP10PhosphateAPAF1HSPB1PARP1PhosphateFASLGGlutathioneHSPB1RIPK2HSPB1MAP2K4SPTAN1MAP3K1APAF1BCL2HSPB1HSPB1CASP9FAF1RB1PhosphateactinMAPKAPK2CASP3DFFALMNAPhosphateMAPK8DFFBHSPB1PRKDCPAK2CeramideTNFCASP6PAK1


Description

This pathway describes the Fas induced apoptosis and interplay with Hsp27 in response to stress. More info: BioCarta.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP314(r21341) with a 79% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Creagh EM, Sheehan D, Cotter TG; ''Heat shock proteins--modulators of apoptosis in tumour cells.''; Leukemia, 2000 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117196view10:32, 18 May 2021EweitzModified title
109460view10:41, 18 March 2020L DupuisConverted interactions to graphical lines where applicable
106117view12:02, 16 August 2019MaintBotHMDB identifier normalization
74234view16:38, 8 April 2014EgonwRemoved a data source where no ID was given.
72376view13:05, 13 November 2013EgonwAdded a metabolite ID.
68807view17:15, 8 July 2013MaintBotUpdated to 2013 gpml schema
67224view10:23, 26 June 2013Christine ChichesterOntology Term : 'FasL mediated signaling pathway' added !
47790view16:27, 6 April 2012Khanspersupdated xref
40940view22:52, 1 March 2011MaintBotRemoved redundant pathway information and comments
38242view21:20, 27 August 2010KhanspersRemoved receptor and protein complex graphics
35562view15:03, 12 February 2010Thomasadded literature
35558view15:01, 12 February 2010ThomasModified description
33869view17:49, 9 December 2009MaintBotAutomatic update of empty xrefs
33466view15:04, 30 November 2009MaintBotRemoved group label
31517view21:39, 13 August 2009MaintBotFixed text labels
30357view20:54, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
APAF1GeneProduct417926 (Entrez Gene)
ARHGDIBGeneProduct417941 (Entrez Gene) Interim Symbol: Arhgdib predicted and Name: Rho, GDP dissociation inhibitor (GDI) beta (predicted)
BCL2GeneProduct396282 (Entrez Gene)
CASP10GeneProduct424081 (Entrez Gene)
CASP3GeneProduct395476 (Entrez Gene)
CASP6GeneProduct395477 (Entrez Gene)
CASP7GeneProduct423901 (Entrez Gene)
CASP8GeneProduct395284 (Entrez Gene)
CASP9GeneProduct426970 (Entrez Gene)
CFLARGeneProduct424080 (Entrez Gene)
CYCSGeneProduct420624 (Entrez Gene)
CeramideMetaboliteCHEBI:17761 (ChEBI)
DAXXGeneProduct
DFFAGeneProduct419451 (Entrez Gene)
DFFBGeneProduct374158 (Entrez Gene)
FADDGeneProduct776859 (Entrez Gene)
FAF1GeneProduct424629 (Entrez Gene)
FAP1GeneProduct
FASGeneProduct395274 (Entrez Gene)
FASLGGeneProduct776371 (Entrez Gene)
GlutathioneMetaboliteHMDB00125 (HMDB)
HSPB1GeneProduct396227 (Entrez Gene)
IL1AGeneProduct
JUNGeneProduct424673 (Entrez Gene)
LMNAGeneProduct396224 (Entrez Gene)
LMNB1GeneProduct396223 (Entrez Gene)
LMNB2GeneProduct396222 (Entrez Gene)
MAP2K4GeneProduct417312 (Entrez Gene)
MAP3K1GeneProduct427144 (Entrez Gene)
MAP3K7GeneProduct421808 (Entrez Gene)
MAPK8GeneProduct423778 (Entrez Gene)
MAPKAPK2GeneProduct419847 (Entrez Gene)
MAPKAPK3GeneProduct415917 (Entrez Gene)
PAK1GeneProduct419083 (Entrez Gene)
PAK2GeneProduct424860 (Entrez Gene)
PARP1GeneProduct396199 (Entrez Gene)
PRKDCGeneProduct395376 (Entrez Gene)
PhosphateMetaboliteHMDB01429 (HMDB)
RB1GeneProduct386582 (Entrez Gene)
RIPK2GeneProduct420215 (Entrez Gene) receptor (TNFRSF)-interacting serine-threonine kinase 2
SPTAN1GeneProduct374234 (Entrez Gene) Interim Symbol: Spna1 predicted and Name: spectrin alpha 1 (predicted)
TNFGeneProduct
actinGeneProduct

Annotated Interactions

No annotated interactions
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