Hair follicle development: induction - stage 1 of 3 (Homo sapiens)

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Dermal MesenchymeEpidermisNucleusNucleus13102029991520291427275, 14115, 14102924LEF115145, 20114, 252821, 2320MYCTCF3/4306175, 271721211571721122, 2318, 217DKK48EDAREDA21B-cateninSP5SHH12GJB6INDUCTION16FOXI3NOG1KRT10TP63IVLCTGFActivin A?MSX2FSTCDH3CTNNB1FGF20VCANDermalaggregativegrowthNF-kB?GLIsWntPathway1stWNT1stWNTDKK4EDAR28EDAEdaPathwayShhPathway12SHH11WNT10BWNT10AFGFR1FGF2017FgfPathwayFZD1WntPathway19LRP5/6WNT10BB-cateninPlacodeformationPTCHSMOPTCHEGFR9FGFR29FGF7EGFEGFRFGFR29?VersicanNogginLEF1NCAMCTGFFollistatin921PlacodeShapeCDH3GJB63WNT10AFZD1LRP5/62BMPR1ABMP sCYTODIFFERENTIATIONORGANOGENESIS1616You are hereClick hereClick here


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Laboratório de Biodados - UFMG / Brazil

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Bibliography

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  2. Richardson GD, Bazzi H, Fantauzzo KA, Waters JM, Crawford H, Hynd P, Christiano AM, Jahoda CA; ''KGF and EGF signalling block hair follicle induction and promote interfollicular epidermal fate in developing mouse skin.''; Development, 2009 PubMed Europe PMC Scholia
  3. Zhang Y, Andl T, Yang SH, Teta M, Liu F, Seykora JT, Tobias JW, Piccolo S, Schmidt-Ullrich R, Nagy A, Taketo MM, Dlugosz AA, Millar SE; ''Activation of beta-catenin signaling programs embryonic epidermis to hair follicle fate.''; Development, 2008 PubMed Europe PMC Scholia
  4. da Silva-Diz V, Solé-Sánchez S, Valdés-Gutiérrez A, Urpí M, Riba-Artés D, Penin RM, Pascual G, González-Suárez E, Casanovas O, Viñals F, Paramio JM, Batlle E, Muñoz P; ''Progeny of Lgr5-expressing hair follicle stem cell contributes to papillomavirus-induced tumor development in epidermis.''; Oncogene, 2013 PubMed Europe PMC Scholia
  5. Fliniaux I, Mikkola ML, Lefebvre S, Thesleff I; ''Identification of dkk4 as a target of Eda-A1/Edar pathway reveals an unexpected role of ectodysplasin as inhibitor of Wnt signalling in ectodermal placodes.''; Dev Biol, 2008 PubMed Europe PMC Scholia
  6. Yang Y, Li Y, Wang Y, Wu J, Yang G, Yang T, Gao Y, Lu Y; ''Versican gene: regulation by the β-catenin signaling pathway plays a significant role in dermal papilla cell aggregative growth.''; J Dermatol Sci, 2012 PubMed Europe PMC Scholia
  7. Botchkarev VA, Botchkareva NV, Roth W, Nakamura M, Chen LH, Herzog W, Lindner G, McMahon JA, Peters C, Lauster R, McMahon AP, Paus R; ''Noggin is a mesenchymally derived stimulator of hair-follicle induction.''; Nat Cell Biol, 1999 PubMed Europe PMC Scholia
  8. Shimomura Y, Wajid M, Shapiro L, Christiano AM; ''P-cadherin is a p63 target gene with a crucial role in the developing human limb bud and hair follicle.''; Development, 2008 PubMed Europe PMC Scholia
  9. Pummila M, Fliniaux I, Jaatinen R, James MJ, Laurikkala J, Schneider P, Thesleff I, Mikkola ML; ''Ectodysplasin has a dual role in ectodermal organogenesis: inhibition of Bmp activity and induction of Shh expression.''; Development, 2007 PubMed Europe PMC Scholia
  10. Hens JR, Dann P, Zhang JP, Harris S, Robinson GW, Wysolmerski J; ''BMP4 and PTHrP interact to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction.''; Development, 2007 PubMed Europe PMC Scholia
  11. Nowak JA, Polak L, Pasolli HA, Fuchs E; ''Hair follicle stem cells are specified and function in early skin morphogenesis.''; Cell Stem Cell, 2008 PubMed Europe PMC Scholia
  12. Reddy S, Andl T, Bagasra A, Lu MM, Epstein DJ, Morrisey EE, Millar SE; ''Characterization of Wnt gene expression in developing and postnatal hair follicles and identification of Wnt5a as a target of Sonic hedgehog in hair follicle morphogenesis.''; Mech Dev, 2001 PubMed Europe PMC Scholia
  13. Cui CY, Kunisada M, Childress V, Michel M, Schlessinger D; ''Shh is required for Tabby hair follicle development.''; Cell Cycle, 2011 PubMed Europe PMC Scholia
  14. Mardaryev AN, Meier N, Poterlowicz K, Sharov AA, Sharova TY, Ahmed MI, Rapisarda V, Lewis C, Fessing MY, Ruenger TM, Bhawan J, Werner S, Paus R, Botchkarev VA; ''Lhx2 differentially regulates Sox9, Tcf4 and Lgr5 in hair follicle stem cells to promote epidermal regeneration after injury.''; Development, 2011 PubMed Europe PMC Scholia
  15. Niemann C, Unden AB, Lyle S, Zouboulis ChC, Toftgård R, Watt FM; ''Indian hedgehog and beta-catenin signaling: role in the sebaceous lineage of normal and neoplastic mammalian epidermis.''; Proc Natl Acad Sci U S A, 2003 PubMed Europe PMC Scholia
  16. Rishikaysh P, Dev K, Diaz D, Qureshi WM, Filip S, Mokry J; ''Signaling involved in hair follicle morphogenesis and development.''; Int J Mol Sci, 2014 PubMed Europe PMC Scholia
  17. Zhang Y, Tomann P, Andl T, Gallant NM, Huelsken J, Jerchow B, Birchmeier W, Paus R, Piccolo S, Mikkola ML, Morrisey EE, Overbeek PA, Scheidereit C, Millar SE, Schmidt-Ullrich R; ''Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction.''; Dev Cell, 2009 PubMed Europe PMC Scholia
  18. Durmowicz MC, Cui CY, Schlessinger D; ''The EDA gene is a target of, but does not regulate Wnt signaling.''; Gene, 2002 PubMed Europe PMC Scholia
  19. Ridgway RA, Serrels B, Mason S, Kinnaird A, Muir M, Patel H, Muller WJ, Sansom OJ, Brunton VG; ''Focal adhesion kinase is required for β-catenin-induced mobilization of epidermal stem cells.''; Carcinogenesis, 2012 PubMed Europe PMC Scholia
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  21. Mou C, Jackson B, Schneider P, Overbeek PA, Headon DJ; ''Generation of the primary hair follicle pattern.''; Proc Natl Acad Sci U S A, 2006 PubMed Europe PMC Scholia
  22. Yamaguchi TP, Bradley A, McMahon AP, Jones S; ''A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo.''; Development, 1999 PubMed Europe PMC Scholia
  23. Shirokova V, Jussila M, Hytönen MK, Perälä N, Drögemüller C, Leeb T, Lohi H, Sainio K, Thesleff I, Mikkola ML; ''Expression of Foxi3 is regulated by ectodysplasin in skin appendage placodes.''; Dev Dyn, 2013 PubMed Europe PMC Scholia
  24. Mukhopadhyay M, Gorivodsky M, Shtrom S, Grinberg A, Niehrs C, Morasso MI, Westphal H; ''Dkk2 plays an essential role in the corneal fate of the ocular surface epithelium.''; Development, 2006 PubMed Europe PMC Scholia
  25. Schneider MR, Schmidt-Ullrich R, Paus R; ''The hair follicle as a dynamic miniorgan.''; Curr Biol, 2009 PubMed Europe PMC Scholia
  26. Chiang C, Swan RZ, Grachtchouk M, Bolinger M, Litingtung Y, Robertson EK, Cooper MK, Gaffield W, Westphal H, Beachy PA, Dlugosz AA; ''Essential role for Sonic hedgehog during hair follicle morphogenesis.''; Dev Biol, 1999 PubMed Europe PMC Scholia
  27. Laurikkala J, Pispa J, Jung HS, Nieminen P, Mikkola M, Wang X, Saarialho-Kere U, Galceran J, Grosschedl R, Thesleff I; ''Regulation of hair follicle development by the TNF signal ectodysplasin and its receptor Edar.''; Development, 2002 PubMed Europe PMC Scholia
  28. Huh SH, Närhi K, Lindfors PH, Häärä O, Yang L, Ornitz DM, Mikkola ML; ''Fgf20 governs formation of primary and secondary dermal condensations in developing hair follicles.''; Genes Dev, 2013 PubMed Europe PMC Scholia
  29. Wang N, Yang T, Li J, Lei M, Shi J, Qiu W, Lian X; ''The expression and role of c-Myc in mouse hair follicle morphogenesis and cycling.''; Acta Histochem, 2012 PubMed Europe PMC Scholia
  30. Bazzi H, Fantauzzo KA, Richardson GD, Jahoda CA, Christiano AM; ''The Wnt inhibitor, Dickkopf 4, is induced by canonical Wnt signaling during ectodermal appendage morphogenesis.''; Dev Biol, 2007 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
129134view14:13, 12 March 2024Mkutmonfix references
129074view14:31, 10 March 2024EweitzModified title
129071view14:10, 10 March 2024EweitzOntology Term : 'hair follicle cell' added !
118091view10:53, 24 May 2021EweitzModified title
115431view10:46, 19 February 2021DeSlAdded other 2 PWs in description with linkout
115430view10:35, 19 February 2021DeSlRemoved email address + last modified item
115429view10:34, 19 February 2021DeSlSmall title change
106725view13:19, 17 September 2019MkutmonHMDB identifier normalization
88629view14:39, 12 August 2016JmeliusOntology Term : 'regulatory pathway' added !
79882view12:11, 23 April 2015Mkutmonadded xrefs for ATP and ADP
79881view12:07, 23 April 2015Mkutmonchanged datanodes without text label to labels
78710view13:44, 18 January 2015EgonwManually added some missing graph IDs.
77319view00:35, 15 August 2014DanieltrinunesModified description
77318view00:34, 15 August 2014DanieltrinunesModified description
77317view22:37, 14 August 2014Danieltrinunes
77316view22:36, 14 August 2014Danieltrinunes
77314view22:27, 14 August 2014DanieltrinunesModified description
75844view21:26, 10 June 2014DanieltrinunesModified title
75843view21:14, 10 June 2014DanieltrinunesChanges in accordance to SBGN pattern.
75842view21:08, 10 June 2014Danieltrinunesok
75524view20:06, 6 June 2014Daniel.trinunesModified title
75437view15:52, 30 May 2014Daniel.trinunesModified description
75373view20:46, 20 May 2014Daniel.trinunesModified description
75372view20:43, 20 May 2014Daniel.trinunesModified description
75371view20:22, 20 May 2014Daniel.trinunesModified description
75370view20:19, 20 May 2014Daniel.trinunesModified description
75369view20:18, 20 May 2014Daniel.trinunesModified description
75228view19:27, 12 May 2014Daniel.trinunesNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
1st WNTGeneProduct
?GeneProduct
? GeneProduct
Activin AGeneProductP08476 (Uniprot-SwissProt)
B-cateninGeneProductP35222 (Uniprot-SwissProt)
BMP sProteinP12644 (Uniprot-SwissProt)
BMPR1AProteinP36894 (Uniprot-SwissProt)
CDH3GeneProductP22223 (Uniprot-SwissProt)
CTGFProteinP29279 (Uniprot-TrEMBL)
CTNNB1GeneProductP35222 (Uniprot-SwissProt)
CYTODIFFERENTIATIONGeneProduct
Click herePathway
DKK4ProteinQ9UBT3 (Uniprot-SwissProt)
Dermal

aggregative

growth
EDAProteinQ92838 (Uniprot-SwissProt)
EDARProteinQ9UNE0 (Uniprot-SwissProt)
EGFProteinP01133 (Uniprot-SwissProt)
EGFRProteinP00533 (Uniprot-SwissProt)
Eda PathwayPathway
FGF20ProteinQ9NP95 (Uniprot-TrEMBL)
FGF7ProteinP21781 (Uniprot-SwissProt)
FGFR1ProteinP11362 (Uniprot-SwissProt)
FGFR2ProteinP21802 (Uniprot-SwissProt)
FOXI3GeneProductA8MTJ6 (Uniprot-SwissProt)
FSTProteinP19883 (Uniprot-TrEMBL)
FZD1ProteinQ9UP38 (Uniprot-SwissProt)
Fgf PathwayPathway
FollistatinProteinP19883 (Uniprot-TrEMBL)
GJB6GeneProductO95452 (Uniprot-SwissProt)
GLIsProteinP08151 (Uniprot-SwissProt)
INDUCTIONGeneProduct
IVLGeneProductP07476 (Uniprot-SwissProt)
KRT10GeneProductP13645 (Uniprot-SwissProt)
LEF1ProteinQ9UJU2 (Uniprot-SwissProt)
LRP5/6ProteinO75197 (Uniprot-SwissProt)
MSX2ProteinP35548 (Uniprot-TrEMBL)
MYCProteinP01106 (Uniprot-SwissProt)
NCAMProteinP13591 (Uniprot-SwissProt)
NF-kBProteinP19838 (Uniprot-SwissProt)
NOG1ProteinQ9BZE4 (Uniprot-SwissProt)
NogginProteinQ9BZE4 (Uniprot-SwissProt)
ORGANOGENESISGeneProduct
PTCHProteinQ13635 (Uniprot-SwissProt)
Placode Shape
Placode formation
SHHProteinQ15465 (Uniprot-SwissProt)
SMOProteinQ99835 (Uniprot-SwissProt)
SP5ProteinQ6BEB4 (Uniprot-SwissProt)
Shh PathwayPathway
TCF3/4ProteinP15884 (Uniprot-SwissProt)
TP63GeneProductQ9H3D4 (Uniprot-SwissProt)
VCANGeneProductP13611 (Uniprot-SwissProt)
VersicanGeneProductP13611 (Uniprot-SwissProt)
WNT10AProteinQ9GZT5 (Uniprot-SwissProt)
WNT10BProteinO00744 (Uniprot-SwissProt)
Wnt PathwayPathway
You are herePathway

Annotated Interactions

No annotated interactions
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