Cocaine metabolism (Homo sapiens)

From WikiPathways

Description

Quality Tags

Ontology Terms

Bibliography

1. Kolbrich EA, Barnes AJ, Gorelick DA, Boyd SJ, Cone EJ, Huestis MA; ''Major and minor metabolites of cocaine in human plasma following controlled subcutaneous cocaine administration.''; J Anal Toxicol, 2006 PubMed Europe PMC Scholia
2. Schneider KJ, DeCaprio AP; ''Evaluation of in vitro metabolic systems for common drugs of abuse. 1. Cocaine.''; Xenobiotica, 2013 PubMed Europe PMC Scholia
3. Kloss MW, Rosen GM, Rauckman EJ; ''N-demethylation of cocaine to norcocaine. Evidence for participation by cytochrome P-450 and FAD-containing monooxygenase.''; Mol Pharmacol, 1983 PubMed Europe PMC Scholia
4. Maurer HH, Sauer C, Theobald DS; ''Toxicokinetics of drugs of abuse: current knowledge of the isoenzymes involved in the human metabolism of tetrahydrocannabinol, cocaine, heroin, morphine, and codeine.''; Ther Drug Monit, 2006 PubMed Europe PMC Scholia
5. Watanabe K, Hida Y, Matsunaga T, Yamamoto I, Yoshimura H; ''Formation of p-hydroxycocaine from cocaine by hepatic microsomes of animals and its pharmacological effects in mice.''; Biol Pharm Bull, 1993 PubMed Europe PMC Scholia

History

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Compare	Revision	Action	Time	User	Comment
	106727	view	13:21, 17 September 2019	MaintBot	HMDB identifier normalization
	95176	view	11:57, 21 November 2017	DeSl	Changed layout.
	95175	view	11:56, 21 November 2017	DeSl	Changed layout, added node for crack cocaine
	95083	view	16:37, 13 November 2017	DeSl	Added additional metabolites, enzymes/proteins changed layout.
	95082	view	15:57, 13 November 2017	DeSl	Added additional metabolic conversion + ezymes/proteins involved
	92529	view	17:51, 13 June 2017	AlexanderPico	Updated layout to display all interactions
	92526	view	14:39, 13 June 2017	DeSl	Trying to fix metabolite name position
	89185	view	03:52, 23 August 2016	Ariutta	Ontology Term : 'cocaine drug pathway' added !
	89184	view	03:51, 23 August 2016	Ariutta	Ontology Term : 'classic metabolic pathway' added !
	88586	view	19:27, 11 August 2016	Mkutmon	fix unconnected lines
	76363	view	09:26, 4 July 2014	Egonw	Periodical save, work in progress
	76211	view	14:31, 17 June 2014	Andra	Modified description
	76210	view	14:23, 17 June 2014	Andra	New pathway

External references

DataNodes

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Name	Type	Database reference	Comment
Benzoylecgonine	Metabolite	395095 (Chemspider)
Cocaine	Metabolite	10194104 (Chemspider)
P-Hydroxybenzoylecgonine	Metabolite	90899-22-2 (CAS)
ecgonine methyl ester	Metabolite	391939 (Chemspider)
m-Hydroxybenzoylecgonine	Metabolite	15607453 (Chemspider)
m-hydroxycocaine	Metabolite	26502800 (Chemspider)
norcocaine	Metabolite	559083 (Chemspider)
p-hydroxycocaine	Metabolite	26502800 (Chemspider)

Annotated Interactions

No annotated interactions