TCA cycle nutrient use and invasiveness of ovarian cancer (Homo sapiens)

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Cancer stageLegendComplex INADH-UbiquinoneComplex IISuccinate-UbiquinoneLow-invasive Ovarian CancerTyrosine phosphorylation pathwayTCA CycleJAK1ERK2LactateGlucoseSTAT3EGFRPyruvateERK1D-GlutamineTyr-PGlucoseSTAT3Ser-PGlucoseEGFRJAK1STAT3Tyr-PHigh-invasive Ovarian CancerSerine phosphorylation pathwayMetabolix flux


Description

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Bibliography

  1. Hornbeck PV, Zhang B, Murray B, Kornhauser JM, Latham V, Skrzypek E; ''PhosphoSitePlus, 2014: mutations, PTMs and recalibrations.''; Nucleic Acids Res, 2015 PubMed Europe PMC Scholia
  2. Yang L, Moss T, Mangala LS, Marini J, Zhao H, Wahlig S, Armaiz-Pena G, Jiang D, Achreja A, Win J, Roopaimoole R, Rodriguez-Aguayo C, Mercado-Uribe I, Lopez-Berestein G, Liu J, Tsukamoto T, Sood AK, Ram PT, Nagrath D; ''Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer.''; Mol Syst Biol, 2014 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
137132view23:11, 27 February 2025KhanspersModified description
136852view13:57, 24 February 2025EweitzFix typo
128641view19:44, 17 February 2024EweitzRefine legend, economize layout, standardize case
127248view17:31, 28 August 2023KhanspersAdded literature reference and updated description
127227view20:03, 25 August 2023Khanspersadded reference
123109view15:01, 3 July 2022EgonwMade a pathway clickable
117183view10:19, 18 May 2021EweitzModified title
112051view17:09, 17 September 2020KhanspersOntology Term : 'ovarian cancer' added !
112050view17:06, 17 September 2020Khanspersupdated phospho sites and added references
108102view10:15, 29 November 2019FehrhartOntology Term : 'cancer pathway' added !
106479view19:43, 3 September 2019KhanspersModified description
106190view12:08, 16 August 2019MaintBotHMDB identifier normalization
105431view04:31, 8 August 2019KhanspersModified description
105408view15:55, 7 August 2019DeSlSmall layout changes to make textLabels more readable.
105391view17:51, 6 August 2019KhanspersModified description
105390view17:51, 6 August 2019KhanspersModified description
105389view17:50, 6 August 2019KhanspersModified description
105388view17:50, 6 August 2019KhanspersModified description
105387view17:49, 6 August 2019KhanspersModified description
90260view23:06, 27 October 2016AlexanderPicoChanged Stat3 to default node color
89885view13:01, 6 October 2016MkutmonModified description
78079view23:52, 30 November 2014Khanspersfixed unconnected interactions
77985view18:05, 4 November 2014KhanspersAdded lit ref and fixed arrow
77984view18:04, 4 November 2014KhanspersOntology Term : 'reproductive system disease' added !
77983view18:03, 4 November 2014KhanspersModified description
77956view19:38, 30 October 2014KhanspersOntology Term : 'altered citric acid cycle pathway' added !
77955view19:34, 30 October 2014KhanspersOntology Term : 'cancer' added !
77954view19:34, 30 October 2014KhanspersModified description
77917view20:00, 29 October 2014KhanspersModified title
77916view19:59, 29 October 2014KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
D-GlutamineMetaboliteHMDB03423 (HMDB)
EGFRGeneProduct1956 (Entrez Gene)
ERK1GeneProduct5595 (Entrez Gene)
ERK2GeneProduct5594 (Entrez Gene)
GlucoseMetaboliteHMDB00122 (HMDB)
JAK1GeneProduct3716 (Entrez Gene)
LactateMetaboliteHMDB00190 (HMDB)
PyruvateMetaboliteHMDB00243 (HMDB)
STAT3GeneProduct6774 (Entrez Gene)
TCA CyclePathwayWP78 (WikiPathways)

Annotated Interactions

No annotated interactions

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