RTK/Ras/MAPK - LET-23, EGL-15 independent (Caenorhabditis elegans)

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1Positive and negative regulators and targets of various RTK/Ras/MAPK signaling pathways in C. elegans. LST-1LET-60/RasLET-92DPY-22LIN-3SUR-6SUR-5EGL-15DPY-23EGL-17LET-756SRA-13?SEM-5PTP-2KSR-1LST-3KSR-2ARK-1LIN-25ELT-6LIN-45/RafMEK-2/MekLET-23DAB-1LST-2GPA-5GTPCLR-1LIN-2LST-4CNK-1??SUR-7EGL-18ROM-1GAP-2EOR-1EFL-1GAP-1LIN-39MPK-1/ErkLRP-2?EOR-2UNC-101DAF-2LIN-10EGL-5SEM-4EGL-19VAB-1LIP-1SOS-1/GEFSUR-2SOC-1LIN-31LIN-7LRP-1PAR-1SOC-2LIN-12EGL-30LIN-35SLI-1CDF-1LIN-1??


Description

This pathway represents the core elements of Receptor Tyrosine Kinase (RTK)/Ras GTPase/MAP kinase (MAPK) pathways. Many developmental events in C. elegans require this signaling pathway with different RTK's providing activation of the pathway in specific cell-types and under different regulatory controls. Depending on the process, this signaling pathway may interact with the Wnt, Notch, or other pathways during development.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Sundaram MV; ''RTK/Ras/MAPK signaling''; WormBook, 2006 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
135386view12:04, 3 September 2024EgonwRemoved the period at the end of the publication title
135367view05:28, 2 September 2024EgonwConverted to use Ensembl identifiers
78457view10:27, 7 January 2015MaintBotadded missing graphIds
71868view08:32, 19 October 2013EgonwAdded a metabolite ID.
71440view19:06, 17 October 2013MaintBotAutomated update of data sources
70988view23:18, 19 September 2013KyookModified description
70987view23:08, 19 September 2013KyookOntology Term : 'the extracellular signal-regulated Raf/Mek/Erk signaling pathway' added !
70986view23:07, 19 September 2013KyookOntology Term : 'Ras mediated signaling pathway' added !
70985view23:05, 19 September 2013KyookNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
?
??GeneProduct
ARK-1GeneProductWBGene00000186 (WormBase)
CDF-1GeneProductWBGene00000393 (WormBase)
CLR-1GeneProductWBGene00000548 (WormBase)
CNK-1GeneProductWBGene00000564 (WormBase)
DAB-1GeneProductWBGene00000894 (WormBase)
DAF-2GeneProductWBGene00000898 (WormBase)
DPY-22GeneProductWBGene00001081 (WormBase)
DPY-23GeneProductWBGene00001082 (WormBase)
EFL-1GeneProductWBGene00001161 (WormBase)
EGL-15GeneProductWBGene00001184 (WormBase)
EGL-17GeneProductWBGene00001185 (WormBase)
EGL-18GeneProductWBGene00001186 (WormBase)
EGL-19GeneProductWBGene00001187 (WormBase)
EGL-30GeneProductWBGene00001196 (WormBase)
EGL-5GeneProductWBGene00001174 (WormBase)
ELT-6GeneProductWBGene00001253 (WormBase)
EOR-1GeneProductWBGene00001324 (WormBase)
EOR-2GeneProductWBGene00001325 (WormBase)
GAP-1GeneProductWBGene00001515 (WormBase)
GAP-2GeneProductWBGene00001516 (WormBase)
GPA-5GeneProductWBGene00001667 (WormBase)
GTPMetaboliteCHEBI:15996 (ChEBI)
KSR-1GeneProductWBGene00002239 (WormBase)
KSR-2GeneProductWBGene00002240 (WormBase)
LET-23GeneProductWBGene00002299 (WormBase)
LET-60/RasGeneProductWBGene00002335 (WormBase)
LET-756GeneProductWBGene00002881 (WormBase)
LET-92GeneProductWBGene00002363 (WormBase)
LIN-10GeneProductWBGene00002999 (WormBase)
LIN-12GeneProductWBGene00003001 (WormBase)
LIN-1GeneProductWBGene00002990 (WormBase)
LIN-25GeneProductWBGene00003011 (WormBase)
LIN-2GeneProductWBGene00002991 (WormBase)
LIN-31GeneProductWBGene00003017 (WormBase)
LIN-35GeneProductWBGene00003020 (WormBase)
LIN-39GeneProductWBGene00003024 (WormBase)
LIN-3GeneProductWBGene00002992 (WormBase)
LIN-45/RafGeneProductWBGene00003030 (WormBase)
LIN-7GeneProductWBGene00002996 (WormBase)
LIP-1GeneProductWBGene00003043 (WormBase)
LRP-1GeneProductWBGene00003071 (WormBase)
LRP-2GeneProductWBGene00003072 (WormBase)
LST-1GeneProductWBGene00003083 (WormBase)
LST-2GeneProductWBGene00003084 (WormBase)
LST-3GeneProductWBGene00003085 (WormBase)
LST-4GeneProductWBGene00003086 (WormBase)
MEK-2/MekGeneProductWBGene00003186 (WormBase)
MPK-1/ErkGeneProductWBGene00003401 (WormBase)
PAR-1GeneProductWBGene00003916 (WormBase)
PTP-2GeneProductWBGene00004214 (WormBase)
ROM-1GeneProductWBGene00004400 (WormBase)
SEM-4GeneProductWBGene00004773 (WormBase)
SEM-5GeneProductWBGene00004774 (WormBase)
SLI-1GeneProductWBGene00004829 (WormBase)
SOC-1GeneProductWBGene00004928 (WormBase)
SOC-2GeneProductWBGene00004929 (WormBase)
SOS-1/GEFGeneProductT28F12.3 (WormBase)
SRA-13GeneProductWBGene00005039 (WormBase)
SUR-2GeneProductWBGene00006349 (WormBase)
SUR-5GeneProductWBGene00006351 (WormBase)
SUR-6GeneProductWBGene00006352 (WormBase)
SUR-7GeneProductWBGene00006353 (WormBase)
UNC-101GeneProductWBGene00006829 (WormBase)
VAB-1GeneProductWBGene00006868 (WormBase)

Annotated Interactions

No annotated interactions

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