Liver X receptor pathway (Homo sapiens)

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49Multi-drug resistanceDrug and steroid metabolismTranscription factorsOtherTranscriptionNR1H325LXR ligandNR1H3LigandGenesTATA boxNR1H3LigandLXRERXRA6, 20RXRA6, 20ABCG825CYP3A428ABCG5CYP2B62528CYP7A1SREBF12823FASNLXR target genes28SCD


Description

The liver X receptor (LXR) is a nuclear receptor involved in the regulation of liver-specific processes, such as cholesterol, fatty acid and glucose homeostasis.

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Bibliography

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History

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CompareRevisionActionTimeUserComment
116465view10:06, 7 May 2021EweitzModified title
106631view20:55, 12 September 2019KhanspersModified description
105637view05:06, 10 August 2019KhanspersModified description
94790view23:00, 5 October 2017AlexanderPicoConverted lines
94780view22:20, 5 October 2017AlexanderPicoConverted lines and reconnected interactions
88692view15:56, 12 August 2016JmeliusOntology Term : 'regulatory pathway' added !
82709view09:24, 23 October 2015EgonwMore specific ChEBI identifier.
79886view13:20, 23 April 2015Mkutmonremoved redundant publication xref (pubmed: 15581595)
79885view12:40, 23 April 2015Mkutmonremoved redundant publication xref (pubmed: 15581595)
79599view05:44, 27 March 2015EgonwFixed a bunch of PubMed references (character encodings, messed up Biopax/XML).
79598view05:36, 27 March 2015EgonwProper ChEBI identifier ("ligand" is the chemical term in ChEBI).
79553view12:22, 25 March 2015FehrhartUpdate of GenIDs and comments
79542view15:07, 24 March 2015RiannefijtenModified description
79541view15:06, 24 March 2015Riannefijtenfixed unconnected lines, added reference, changed pathway nodes to labels
79484view13:05, 23 March 2015EgonwAnnotated "ligand" with its ChEBI identifier.
78513view10:29, 7 January 2015MaintBotadded missing graphIds
78254view22:06, 17 December 2014KhanspersModified title
78214view15:03, 14 December 2014MaintBotModified title
78213view14:58, 14 December 2014EgonwChanged GPML schema.
78087view11:37, 2 December 2014RiannefijtenNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABCG5GeneProductENSG00000138075 (Ensembl Human)
ABCG8GeneProductENSG00000143921 (Ensembl Human)
CYP2B6GeneProductENSG00000197408 (Ensembl Human)
CYP3A4GeneProductENSG00000160868 (Ensembl Human)
CYP7A1GeneProductENSG00000167910 (Ensembl Human) is not affected in human
FASNGeneProductENSG00000169710 (Ensembl Human)
LXR ligandMetaboliteCHEBI:52214 (ChEBI) T3
LigandMetaboliteCHEBI:52214 (ChEBI)
NR1H3GeneProductENSG00000025434 (Ensembl Human)
RXRAGeneProductENSG00000186350 (Ensembl Human)
SCDGeneProductENSG00000099194 (Ensembl Human)
SREBF1GeneProductENSG00000072310 (Ensembl Human)

Annotated Interactions

No annotated interactions

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