Liver X receptor pathway (Homo sapiens)
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Description
The liver X receptor (LXR) is a nuclear receptor involved in the regulation of liver-specific processes, such as cholesterol, fatty acid and glucose homeostasis.
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- Tachibana K, Kobayashi Y, Tanaka T, Tagami M, Sugiyama A, Katayama T, Ueda C, Yamasaki D, Ishimoto K, Sumitomo M, Uchiyama Y, Kohro T, Sakai J, Hamakubo T, Kodama T, Doi T; ''''; , PubMed Europe PMC Scholia
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
ABCG5 | GeneProduct | 64240 (Entrez Gene) | ATP-binding cassette, sub-family G (WHITE), member 5 |
ABCG8 | GeneProduct | 64241 (Entrez Gene) | ATP-binding cassette, sub-family G (WHITE), member 8 |
CYP2B6 | GeneProduct | 1555 (Entrez Gene) | cytochrome P450, family 2, subfamily B, polypeptide 6 |
CYP3A4 | GeneProduct | 1576 (Entrez Gene) | cytochrome P450, family 3, subfamily A, polypeptide 4 |
CYP7A1 | GeneProduct | 1581 (Entrez Gene) | cytochrome P450, family 7, subfamily A, polypeptide 1 , is not affected in human |
FASN | GeneProduct | 2194 (Entrez Gene) | fatty acid synthase |
LXR ligand | Metabolite | CHEBI:52214 (ChEBI) | T3 |
Ligand | Metabolite | CHEBI:52214 (ChEBI) | |
NR1H3 | GeneProduct | 10062 (Entrez Gene) | nuclear receptor subfamily 1, group H, member 3 |
RXRA | GeneProduct | 6256 (Entrez Gene) | retinoid X receptor, alpha |
SCD | GeneProduct | 6319 (Entrez Gene) | |
SREBF1 | GeneProduct | 6720 (Entrez Gene) | sterol regulatory element binding transcription factor 1 |
Annotated Interactions
No annotated interactions