TCF dependent signaling in response to WNT (Homo sapiens)

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15. Michiue T, Fukui A, Yukita A, Sakurai K, Danno H, Kikuchi A, Asashima M.; ''XIdax, an inhibitor of the canonical Wnt pathway, is required for anterior neural structure formation in Xenopus.''; PubMed Europe PMC Scholia
16. Gross JC, Chaudhary V, Bartscherer K, Boutros M.; ''Active Wnt proteins are secreted on exosomes.''; PubMed Europe PMC Scholia
17. Sampietro J, Dahlberg CL, Cho US, Hinds TR, Kimelman D, Xu W.; ''Crystal structure of a beta-catenin/BCL9/Tcf4 complex.''; PubMed Europe PMC Scholia
18. Wang K, Zhang Y, Li X, Chen L, Wang H, Wu J, Zheng J, Wu D.; ''Characterization of the Kremen-binding site on Dkk1 and elucidation of the role of Kremen in Dkk-mediated Wnt antagonism.''; PubMed Europe PMC Scholia
19. Zhang Y, Liu S, Mickanin C, Feng Y, Charlat O, Michaud GA, Schirle M, Shi X, Hild M, Bauer A, Myer VE, Finan PM, Porter JA, Huang SM, Cong F.; ''RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling.''; PubMed Europe PMC Scholia
20. Yanagawa S, van Leeuwen F, Wodarz A, Klingensmith J, Nusse R.; ''The dishevelled protein is modified by wingless signaling in Drosophila.''; PubMed Europe PMC Scholia
21. Mukai A, Yamamoto-Hino M, Awano W, Watanabe W, Komada M, Goto S.; ''Balanced ubiquitylation and deubiquitylation of Frizzled regulate cellular responsiveness to Wg/Wnt.''; PubMed Europe PMC Scholia
22. Gao ZH, Seeling JM, Hill V, Yochum A, Virshup DM.; ''Casein kinase I phosphorylates and destabilizes the beta-catenin degradation complex.''; PubMed Europe PMC Scholia
23. Kawano Y, Kypta R.; ''Secreted antagonists of the Wnt signalling pathway.''; PubMed Europe PMC Scholia
24. Guo L, Zhong D, Lau S, Liu X, Dong XY, Sun X, Yang VW, Vertino PM, Moreno CS, Varma V, Dong JT, Zhou W.; ''Sox7 Is an independent checkpoint for beta-catenin function in prostate and colon epithelial cells.''; PubMed Europe PMC Scholia
25. Mao B, Niehrs C.; ''Kremen2 modulates Dickkopf2 activity during Wnt/LRP6 signaling.''; PubMed Europe PMC Scholia
26. Brott BK, Sokol SY.; ''Regulation of Wnt/LRP signaling by distinct domains of Dickkopf proteins.''; PubMed Europe PMC Scholia
27. Sierra J, Yoshida T, Joazeiro CA, Jones KA.; ''The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes.''; PubMed Europe PMC Scholia
28. Fagotto F, Glück U, Gumbiner BM.; ''Nuclear localization signal-independent and importin/karyopherin-independent nuclear import of beta-catenin.''; PubMed Europe PMC Scholia
29. MacDonald BT, Yokota C, Tamai K, Zeng X, He X.; ''Wnt signal amplification via activity, cooperativity, and regulation of multiple intracellular PPPSP motifs in the Wnt co-receptor LRP6.''; PubMed Europe PMC Scholia
30. Xing Y, Clements WK, Le Trong I, Hinds TR, Stenkamp R, Kimelman D, Xu W.; ''Crystal structure of a beta-catenin/APC complex reveals a critical role for APC phosphorylation in APC function.''; PubMed Europe PMC Scholia
31. Korinek V, Barker N, Willert K, Molenaar M, Roose J, Wagenaar G, Markman M, Lamers W, Destree O, Clevers H.; ''Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse.''; PubMed Europe PMC Scholia
32. Klimowski LK, Garcia BA, Shabanowitz J, Hunt DF, Virshup DM.; ''Site-specific casein kinase 1epsilon-dependent phosphorylation of Dishevelled modulates beta-catenin signaling.''; PubMed Europe PMC Scholia
33. Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, Page-McCaw A, Lee E.; ''The way Wnt works: components and mechanism.''; PubMed Europe PMC Scholia
34. Korkut C, Ataman B, Ramachandran P, Ashley J, Barria R, Gherbesi N, Budnik V.; ''Trans-synaptic transmission of vesicular Wnt signals through Evi/Wntless.''; PubMed Europe PMC Scholia
35. Rodriguez J, Esteve P, Weinl C, Ruiz JM, Fermin Y, Trousse F, Dwivedy A, Holt C, Bovolenta P.; ''SFRP1 regulates the growth of retinal ganglion cell axons through the Fz2 receptor.''; PubMed Europe PMC Scholia
36. MacDonald BT, Tamai K, He X.; ''Wnt/beta-catenin signaling: components, mechanisms, and diseases.''; PubMed Europe PMC Scholia
37. van Amerongen R, van der Gulden H, Bleeker F, Jonkers J, Berns A.; ''Characterization and functional analysis of the murine Frat2 gene.''; PubMed Europe PMC Scholia
38. Jonkers J, Korswagen HC, Acton D, Breuer M, Berns A.; ''Activation of a novel proto-oncogene, Frat1, contributes to progression of mouse T-cell lymphomas.''; PubMed Europe PMC Scholia
39. Malinauskas T, Aricescu AR, Lu W, Siebold C, Jones EY.; ''Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1.''; PubMed Europe PMC Scholia
40. Willert K, Brink M, Wodarz A, Varmus H, Nusse R.; ''Casein kinase 2 associates with and phosphorylates dishevelled.''; PubMed Europe PMC Scholia
41. Townsley FM, Cliffe A, Bienz M.; ''Pygopus and Legless target Armadillo/beta-catenin to the nucleus to enable its transcriptional co-activator function.''; PubMed Europe PMC Scholia
42. Wu X, Tu X, Joeng KS, Hilton MJ, Williams DA, Long F.; ''Rac1 activation controls nuclear localization of beta-catenin during canonical Wnt signaling.''; PubMed Europe PMC Scholia
43. Wu CH, Nusse R.; ''Ligand receptor interactions in the Wnt signaling pathway in Drosophila.''; PubMed Europe PMC Scholia
44. Tamai K, Zeng X, Liu C, Zhang X, Harada Y, Chang Z, He X.; ''A mechanism for Wnt coreceptor activation.''; PubMed Europe PMC Scholia
45. Sánchez-Hernández D, Sierra J, Ortigão-Farias JR, Guerrero I.; ''The WIF domain of the human and Drosophila Wif-1 secreted factors confers specificity for Wnt or Hedgehog.''; PubMed Europe PMC Scholia
46. Ye X, Wu F, Wu C, Wang P, Jung K, Gopal K, Ma Y, Li L, Lai R.; ''β-Catenin, a Sox2 binding partner, regulates the DNA binding and transcriptional activity of Sox2 in breast cancer cells.''; PubMed Europe PMC Scholia
47. Kimelman D, Xu W.; ''beta-catenin destruction complex: insights and questions from a structural perspective.''; PubMed Europe PMC Scholia
48. Fujii N, You L, Xu Z, Uematsu K, Shan J, He B, Mikami I, Edmondson LR, Neale G, Zheng J, Guy RK, Jablons DM.; ''An antagonist of dishevelled protein-protein interaction suppresses beta-catenin-dependent tumor cell growth.''; PubMed Europe PMC Scholia
49. van Amerongen R, Berns A.; ''Re-evaluating the role of Frat in Wnt-signal transduction.''; PubMed Europe PMC Scholia
50. Keeble TR, Halford MM, Seaman C, Kee N, Macheda M, Anderson RB, Stacker SA, Cooper HM.; ''The Wnt receptor Ryk is required for Wnt5a-mediated axon guidance on the contralateral side of the corpus callosum.''; PubMed Europe PMC Scholia
51. Jiang X, Hao HX, Growney JD, Woolfenden S, Bottiglio C, Ng N, Lu B, Hsieh MH, Bagdasarian L, Meyer R, Smith TR, Avello M, Charlat O, Xie Y, Porter JA, Pan S, Liu J, McLaughlin ME, Cong F.; ''Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma.''; PubMed Europe PMC Scholia
52. Leung JY, Kolligs FT, Wu R, Zhai Y, Kuick R, Hanash S, Cho KR, Fearon ER.; ''Activation of AXIN2 expression by beta-catenin-T cell factor. A feedback repressor pathway regulating Wnt signaling.''; PubMed Europe PMC Scholia
53. Kim KA, Kakitani M, Zhao J, Oshima T, Tang T, Binnerts M, Liu Y, Boyle B, Park E, Emtage P, Funk WD, Tomizuka K.; ''Mitogenic influence of human R-spondin1 on the intestinal epithelium.''; PubMed Europe PMC Scholia
54. Yamamoto H, Sakane H, Yamamoto H, Michiue T, Kikuchi A.; ''Wnt3a and Dkk1 regulate distinct internalization pathways of LRP6 to tune the activation of beta-catenin signaling.''; PubMed Europe PMC Scholia
55. Ahn VE, Chu ML, Choi HJ, Tran D, Abo A, Weis WI.; ''Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6.''; PubMed Europe PMC Scholia
56. Chen G, Courey AJ.; ''Groucho/TLE family proteins and transcriptional repression.''; PubMed Europe PMC Scholia
57. Voges D, Zwickl P, Baumeister W.; ''The 26S proteasome: a molecular machine designed for controlled proteolysis.''; PubMed Europe PMC Scholia
58. Kessler R, Hausmann G, Basler K.; ''The PHD domain is required to link Drosophila Pygopus to Legless/beta-catenin and not to histone H3.''; PubMed Europe PMC Scholia
59. Bax B, Carter PS, Lewis C, Guy AR, Bridges A, Tanner R, Pettman G, Mannix C, Culbert AA, Brown MJ, Smith DG, Reith AD.; ''The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation.''; PubMed Europe PMC Scholia
60. Takada R, Satomi Y, Kurata T, Ueno N, Norioka S, Kondoh H, Takao T, Takada S.; ''Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion.''; PubMed Europe PMC Scholia
61. Bauer A, Huber O, Kemler R.; ''Pontin52, an interaction partner of beta-catenin, binds to the TATA box binding protein.''; PubMed Europe PMC Scholia
62. Li B, Rhéaume C, Teng A, Bilanchone V, Munguia JE, Hu M, Jessen S, Piccolo S, Waterman ML, Dai X.; ''Developmental phenotypes and reduced Wnt signaling in mice deficient for pygopus 2.''; PubMed Europe PMC Scholia
63. Wilson BG, Roberts CW.; ''SWI/SNF nucleosome remodellers and cancer.''; PubMed Europe PMC Scholia
64. Semënov M, Tamai K, He X.; ''SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor.''; PubMed Europe PMC Scholia
65. Valenta T, Hausmann G, Basler K.; ''The many faces and functions of β-catenin.''; PubMed Europe PMC Scholia
66. Sansom OJ, Meniel VS, Muncan V, Phesse TJ, Wilkins JA, Reed KR, Vass JK, Athineos D, Clevers H, Clarke AR.; ''Myc deletion rescues Apc deficiency in the small intestine.''; PubMed Europe PMC Scholia
67. Li L, Yuan H, Weaver CD, Mao J, Farr GH, Sussman DJ, Jonkers J, Kimelman D, Wu D.; ''Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1.''; PubMed Europe PMC Scholia
68. Molenaar M, van de Wetering M, Oosterwegel M, Peterson-Maduro J, Godsave S, Korinek V, Roose J, Destrée O, Clevers H.; ''XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos.''; PubMed Europe PMC Scholia
69. Krieghoff E, Behrens J, Mayr B.; ''Nucleo-cytoplasmic distribution of beta-catenin is regulated by retention.''; PubMed Europe PMC Scholia
70. Lévy L, Wei Y, Labalette C, Wu Y, Renard CA, Buendia MA, Neuveut C.; ''Acetylation of beta-catenin by p300 regulates beta-catenin-Tcf4 interaction.''; PubMed Europe PMC Scholia
71. Saitoh T, Moriwaki J, Koike J, Takagi A, Miwa T, Shiokawa K, Katoh M.; ''Molecular cloning and characterization of FRAT2, encoding a positive regulator of the WNT signaling pathway.''; PubMed Europe PMC Scholia
72. Cheng Z, Biechele T, Wei Z, Morrone S, Moon RT, Wang L, Xu W.; ''Crystal structures of the extracellular domain of LRP6 and its complex with DKK1.''; PubMed Europe PMC Scholia
73. Zeng X, Tamai K, Doble B, Li S, Huang H, Habas R, Okamura H, Woodgett J, He X.; ''A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation.''; PubMed Europe PMC Scholia
74. Gu B, Sun P, Yuan Y, Moraes RC, Li A, Teng A, Agrawal A, Rhéaume C, Bilanchone V, Veltmaat JM, Takemaru K, Millar S, Lee EY, Lewis MT, Li B, Dai X.; ''Pygo2 expands mammary progenitor cells by facilitating histone H3 K4 methylation.''; PubMed Europe PMC Scholia
75. Sun Y, Kolligs FT, Hottiger MO, Mosavin R, Fearon ER, Nabel GJ.; ''Regulation of beta -catenin transformation by the p300 transcriptional coactivator.''; PubMed Europe PMC Scholia
76. Bernatik O, Ganji RS, Dijksterhuis JP, Konik P, Cervenka I, Polonio T, Krejci P, Schulte G, Bryja V.; ''Sequential activation and inactivation of Dishevelled in the Wnt/beta-catenin pathway by casein kinases.''; PubMed Europe PMC Scholia
77. Yamamoto H, Komekado H, Kikuchi A.; ''Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin.''; PubMed Europe PMC Scholia
78. Bovolenta P, Esteve P, Ruiz JM, Cisneros E, Lopez-Rios J.; ''Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease.''; PubMed Europe PMC Scholia
79. Bastide P, Darido C, Pannequin J, Kist R, Robine S, Marty-Double C, Bibeau F, Scherer G, Joubert D, Hollande F, Blache P, Jay P.; ''Sox9 regulates cell proliferation and is required for Paneth cell differentiation in the intestinal epithelium.''; PubMed Europe PMC Scholia
80. Juhlin CC, Haglund F, Villablanca A, Forsberg L, Sandelin K, Bränström R, Larsson C, Höög A.; ''Loss of expression for the Wnt pathway components adenomatous polyposis coli and glycogen synthase kinase 3-beta in parathyroid carcinomas.''; PubMed Europe PMC Scholia
81. Hao HX, Xie Y, Zhang Y, Charlat O, Oster E, Avello M, Lei H, Mickanin C, Liu D, Ruffner H, Mao X, Ma Q, Zamponi R, Bouwmeester T, Finan PM, Kirschner MW, Porter JA, Serluca FC, Cong F.; ''ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner.''; PubMed Europe PMC Scholia
82. Lyu J, Yamamoto V, Lu W.; ''Cleavage of the Wnt receptor Ryk regulates neuronal differentiation during cortical neurogenesis.''; PubMed Europe PMC Scholia
83. Takash W, Cañizares J, Bonneaud N, Poulat F, Mattéi MG, Jay P, Berta P.; ''SOX7 transcription factor: sequence, chromosomal localisation, expression, transactivation and interference with Wnt signalling.''; PubMed Europe PMC Scholia
84. Zeng X, Huang H, Tamai K, Zhang X, Harada Y, Yokota C, Almeida K, Wang J, Doble B, Woodgett J, Wynshaw-Boris A, Hsieh JC, He X.; ''Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions.''; PubMed Europe PMC Scholia
85. Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.; ''Exosomes mediate stromal mobilization of autocrine Wnt-PCP signaling in breast cancer cell migration.''; PubMed Europe PMC Scholia
86. Keeble TR, Cooper HM.; ''Ryk: a novel Wnt receptor regulating axon pathfinding.''; PubMed Europe PMC Scholia
87. Bilic J, Huang YL, Davidson G, Zimmermann T, Cruciat CM, Bienz M, Niehrs C.; ''Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation.''; PubMed Europe PMC Scholia
88. Park JI, Venteicher AS, Hong JY, Choi J, Jun S, Shkreli M, Chang W, Meng Z, Cheung P, Ji H, McLaughlin M, Veenstra TD, Nusse R, McCrea PD, Artandi SE.; ''Telomerase modulates Wnt signalling by association with target gene chromatin.''; PubMed Europe PMC Scholia
89. Tauriello DV, Jordens I, Kirchner K, Slootstra JW, Kruitwagen T, Bouwman BA, Noutsou M, Rüdiger SG, Schwamborn K, Schambony A, Maurice MM.; ''Wnt/β-catenin signaling requires interaction of the Dishevelled DEP domain and C terminus with a discontinuous motif in Frizzled.''; PubMed Europe PMC Scholia
90. He X, Semenov M, Tamai K, Zeng X.; ''LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way.''; PubMed Europe PMC Scholia
91. Ikeda S, Kishida S, Yamamoto H, Murai H, Koyama S, Kikuchi A.; ''Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin.''; PubMed Europe PMC Scholia
92. Peters JM, McKay RM, McKay JP, Graff JM.; ''Casein kinase I transduces Wnt signals.''; PubMed Europe PMC Scholia
93. Chen Y, Shi L, Zhang L, Li R, Liang J, Yu W, Sun L, Yang X, Wang Y, Zhang Y, Shang Y.; ''The molecular mechanism governing the oncogenic potential of SOX2 in breast cancer.''; PubMed Europe PMC Scholia
94. Johannes L, Wunder C.; ''The SNXy flavours of endosomal sorting.''; PubMed Europe PMC Scholia
95. Schwarz-Romond T, Fiedler M, Shibata N, Butler PJ, Kikuchi A, Higuchi Y, Bienz M.; ''The DIX domain of Dishevelled confers Wnt signaling by dynamic polymerization.''; PubMed Europe PMC Scholia
96. Chu ML, Ahn VE, Choi HJ, Daniels DL, Nusse R, Weis WI.; ''structural Studies of Wnts and identification of an LRP6 binding site.''; PubMed Europe PMC Scholia
97. Pinto M, Lobe CG.; ''Products of the grg (Groucho-related gene) family can dimerize through the amino-terminal Q domain.''; PubMed Europe PMC Scholia
98. Wilkins JA, Sansom OJ.; ''C-Myc is a critical mediator of the phenotypes of Apc loss in the intestine.''; PubMed Europe PMC Scholia
99. Takemaru K, Yamaguchi S, Lee YS, Zhang Y, Carthew RW, Moon RT.; ''Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathway.''; PubMed Europe PMC Scholia
100. Bourhis E, Wang W, Tam C, Hwang J, Zhang Y, Spittler D, Huang OW, Gong Y, Estevez A, Zilberleyb I, Rouge L, Chiu C, Wu Y, Costa M, Hannoush RN, Franke Y, Cochran AG.; ''Wnt antagonists bind through a short peptide to the first β-propeller domain of LRP5/6.''; PubMed Europe PMC Scholia
101. Takahashi A, Tsutsumi R, Kikuchi I, Obuse C, Saito Y, Seidi A, Karisch R, Fernandez M, Cho T, Ohnishi N, Rozenblatt-Rosen O, Meyerson M, Neel BG, Hatakeyama M.; ''SHP2 tyrosine phosphatase converts parafibromin/Cdc73 from a tumor suppressor to an oncogenic driver.''; PubMed Europe PMC Scholia
102. Angers S, Thorpe CJ, Biechele TL, Goldenberg SJ, Zheng N, MacCoss MJ, Moon RT.; ''The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation.''; PubMed Europe PMC Scholia
103. Biechele S, Cox BJ, Rossant J.; ''Porcupine homolog is required for canonical Wnt signaling and gastrulation in mouse embryos.''; PubMed Europe PMC Scholia
104. Wawrzak D, Métioui M, Willems E, Hendrickx M, de Genst E, Leyns L.; ''Wnt3a binds to several sFRPs in the nanomolar range.''; PubMed Europe PMC Scholia
105. Qin Y, Li L, Pan W, Wu D.; ''Regulation of phosphatidylinositol kinases and metabolism by Wnt3a and Dvl.''; PubMed Europe PMC Scholia
106. Bartscherer K, Pelte N, Ingelfinger D, Boutros M.; ''Secretion of Wnt ligands requires Evi, a conserved transmembrane protein.''; PubMed Europe PMC Scholia
107. Jho E, Lomvardas S, Costantini F.; ''A GSK3beta phosphorylation site in axin modulates interaction with beta-catenin and Tcf-mediated gene expression.''; PubMed Europe PMC Scholia
108. Kadoya T, Kishida S, Fukui A, Hinoi T, Michiue T, Asashima M, Kikuchi A.; ''Inhibition of Wnt signaling pathway by a novel axin-binding protein.''; PubMed Europe PMC Scholia
109. Hamada F, Bienz M.; ''The APC tumor suppressor binds to C-terminal binding protein to divert nuclear beta-catenin from TCF.''; PubMed Europe PMC Scholia
110. Carmon KS, Gong X, Lin Q, Thomas A, Liu Q.; ''R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling.''; PubMed Europe PMC Scholia
111. Fradkin LG, Dura JM, Noordermeer JN.; ''Ryks: new partners for Wnts in the developing and regenerating nervous system.''; PubMed Europe PMC Scholia
112. Voronina VA, Takemaru K, Treuting P, Love D, Grubb BR, Hajjar AM, Adams A, Li FQ, Moon RT.; ''Inactivation of Chibby affects function of motile airway cilia.''; PubMed Europe PMC Scholia
113. Zhang L, Gao X, Wen J, Ning Y, Chen YG.; ''Dapper 1 antagonizes Wnt signaling by promoting dishevelled degradation.''; PubMed Europe PMC Scholia
114. Freemantle SJ, Portland HB, Ewings K, Dmitrovsky F, DiPetrillo K, Spinella MJ, Dmitrovsky E.; ''Characterization and tissue-specific expression of human GSK-3-binding proteins FRAT1 and FRAT2.''; PubMed Europe PMC Scholia
115. Lu W, Yamamoto V, Ortega B, Baltimore D.; ''Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth.''; PubMed Europe PMC Scholia
116. Yeh TY, Meyer TN, Schwesinger C, Tsun ZY, Lee RM, Chi NW.; ''Tankyrase recruitment to the lateral membrane in polarized epithelial cells: regulation by cell-cell contact and protein poly(ADP-ribosyl)ation.''; PubMed Europe PMC Scholia
117. Schwab KR, Patterson LT, Hartman HA, Song N, Lang RA, Lin X, Potter SS.; ''Pygo1 and Pygo2 roles in Wnt signaling in mammalian kidney development.''; PubMed Europe PMC Scholia
118. Daniels DL, Weis WI.; ''ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules.''; PubMed Europe PMC Scholia
119. Poy F, Lepourcelet M, Shivdasani RA, Eck MJ.; ''Structure of a human Tcf4-beta-catenin complex.''; PubMed Europe PMC Scholia
120. Graham TA, Clements WK, Kimelman D, Xu W.; ''The crystal structure of the beta-catenin/ICAT complex reveals the inhibitory mechanism of ICAT.''; PubMed Europe PMC Scholia
121. Topol L, Chen W, Song H, Day TF, Yang Y.; ''Sox9 inhibits Wnt signaling by promoting beta-catenin phosphorylation in the nucleus.''; PubMed Europe PMC Scholia
122. Bauer A, Chauvet S, Huber O, Usseglio F, Rothbächer U, Aragnol D, Kemler R, Pradel J.; ''Pontin52 and reptin52 function as antagonistic regulators of beta-catenin signalling activity.''; PubMed Europe PMC Scholia
123. Burstein E, Ganesh L, Dick RD, van De Sluis B, Wilkinson JC, Klomp LW, Wijmenga C, Brewer GJ, Nabel GJ, Duckett CS.; ''A novel role for XIAP in copper homeostasis through regulation of MURR1.''; PubMed Europe PMC Scholia
124. Hsieh JC, Kodjabachian L, Rebbert ML, Rattner A, Smallwood PM, Samos CH, Nusse R, Dawid IB, Nathans J.; ''A new secreted protein that binds to Wnt proteins and inhibits their activities.''; PubMed Europe PMC Scholia
125. Schuldt A.; ''Membrane trafficking: a GSK3 lockdown.''; PubMed Europe PMC Scholia
126. Kim W, Kim M, Jho EH.; ''Wnt/β-catenin signalling: from plasma membrane to nucleus.''; PubMed Europe PMC Scholia
127. Li X, Zhang Y, Kang H, Liu W, Liu P, Zhang J, Harris SE, Wu D.; ''Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling.''; PubMed Europe PMC Scholia
128. Bafico A, Gazit A, Pramila T, Finch PW, Yaniv A, Aaronson SA.; ''Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling.''; PubMed Europe PMC Scholia
129. Berndt JD, Aoyagi A, Yang P, Anastas JN, Tang L, Moon RT.; ''Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signaling.''; PubMed Europe PMC Scholia
130. Glinka A, Dolde C, Kirsch N, Huang YL, Kazanskaya O, Ingelfinger D, Boutros M, Cruciat CM, Niehrs C.; ''LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling.''; PubMed Europe PMC Scholia
131. Ikeda S, Kishida M, Matsuura Y, Usui H, Kikuchi A.; ''GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin.''; PubMed Europe PMC Scholia
132. de Lau W, Barker N, Low TY, Koo BK, Li VS, Teunissen H, Kujala P, Haegebarth A, Peters PJ, van de Wetering M, Stange DE, van Es JE, Guardavaccaro D, Schasfoort RB, Mohri Y, Nishimori K, Mohammed S, Heck AJ, Clevers H.; ''Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling.''; PubMed Europe PMC Scholia
133. Yokoya F, Imamoto N, Tachibana T, Yoneda Y.; ''beta-catenin can be transported into the nucleus in a Ran-unassisted manner.''; PubMed Europe PMC Scholia
134. Zhang N, Wei P, Gong A, Chiu WT, Lee HT, Colman H, Huang H, Xue J, Liu M, Wang Y, Sawaya R, Xie K, Yung WK, Medema RH, He X, Huang S.; ''FoxM1 promotes β-catenin nuclear localization and controls Wnt target-gene expression and glioma tumorigenesis.''; PubMed Europe PMC Scholia
135. Li FQ, Mofunanya A, Fischer V, Hall J, Takemaru K.; ''Nuclear-cytoplasmic shuttling of Chibby controls beta-catenin signaling.''; PubMed Europe PMC Scholia
136. Ekici AB, Hilfinger D, Jatzwauk M, Thiel CT, Wenzel D, Lorenz I, Boltshauser E, Goecke TW, Staatz G, Morris-Rosendahl DJ, Sticht H, Hehr U, Reis A, Rauch A.; ''Disturbed Wnt Signalling due to a Mutation in CCDC88C Causes an Autosomal Recessive Non-Syndromic Hydrocephalus with Medial Diverticulum.''; PubMed Europe PMC Scholia
137. Mao J, Wang J, Liu B, Pan W, Farr GH, Flynn C, Yuan H, Takada S, Kimelman D, Li L, Wu D.; ''Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway.''; PubMed Europe PMC Scholia
138. Lustig B, Jerchow B, Sachs M, Weiler S, Pietsch T, Karsten U, van de Wetering M, Clevers H, Schlag PM, Birchmeier W, Behrens J.; ''Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors.''; PubMed Europe PMC Scholia
139. Takemaru KI, Moon RT.; ''The transcriptional coactivator CBP interacts with beta-catenin to activate gene expression.''; PubMed Europe PMC Scholia
140. Chen B, Dodge ME, Tang W, Lu J, Ma Z, Fan CW, Wei S, Hao W, Kilgore J, Williams NS, Roth MG, Amatruda JF, Chen C, Lum L.; ''Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.''; PubMed Europe PMC Scholia
141. Levanon D, Goldstein RE, Bernstein Y, Tang H, Goldenberg D, Stifani S, Paroush Z, Groner Y.; ''Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors.''; PubMed Europe PMC Scholia
142. Hecht A, Vleminckx K, Stemmler MP, van Roy F, Kemler R.; ''The p300/CBP acetyltransferases function as transcriptional coactivators of beta-catenin in vertebrates.''; PubMed Europe PMC Scholia
143. Iguchi H, Urashima Y, Inagaki Y, Ikeda Y, Okamura M, Tanaka T, Uchida A, Yamamoto TT, Kodama T, Sakai J.; ''SOX6 suppresses cyclin D1 promoter activity by interacting with beta-catenin and histone deacetylase 1, and its down-regulation induces pancreatic beta-cell proliferation.''; PubMed Europe PMC Scholia
144. Sakanaka C, Leong P, Xu L, Harrison SD, Williams LT.; ''Casein kinase iepsilon in the wnt pathway: regulation of beta-catenin function.''; PubMed Europe PMC Scholia
145. He TC, Sparks AB, Rago C, Hermeking H, Zawel L, da Costa LT, Morin PJ, Vogelstein B, Kinzler KW.; ''Identification of c-MYC as a target of the APC pathway.''; PubMed Europe PMC Scholia
146. Rothbächer U, Laurent MN, Deardorff MA, Klein PS, Cho KW, Fraser SE.; ''Dishevelled phosphorylation, subcellular localization and multimerization regulate its role in early embryogenesis.''; PubMed Europe PMC Scholia
147. Wei Q, Yokota C, Semenov MV, Doble B, Woodgett J, He X.; ''R-spondin1 is a high affinity ligand for LRP6 and induces LRP6 phosphorylation and beta-catenin signaling.''; PubMed Europe PMC Scholia
148. Daniels DL, Weis WI.; ''Beta-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation.''; PubMed Europe PMC Scholia
149. Semënov MV, Snyder M.; ''Human dishevelled genes constitute a DHR-containing multigene family.''; PubMed Europe PMC Scholia
150. Bányai L, Kerekes K, Patthy L.; ''Characterization of a Wnt-binding site of the WIF-domain of Wnt inhibitory factor-1.''; PubMed Europe PMC Scholia
151. Moumen M, Chiche A, Decraene C, Petit V, Gandarillas A, Deugnier MA, Glukhova MA, Faraldo MM.; ''Myc is required for β-catenin-mediated mammary stem cell amplification and tumorigenesis.''; PubMed Europe PMC Scholia
152. Song N, Schwab KR, Patterson LT, Yamaguchi T, Lin X, Potter SS, Lang RA.; ''pygopus 2 has a crucial, Wnt pathway-independent function in lens induction.''; PubMed Europe PMC Scholia
153. Pan W, Choi SC, Wang H, Qin Y, Volpicelli-Daley L, Swan L, Lucast L, Khoo C, Zhang X, Li L, Abrams CS, Sokol SY, Wu D.; ''Wnt3a-mediated formation of phosphatidylinositol 4,5-bisphosphate regulates LRP6 phosphorylation.''; PubMed Europe PMC Scholia
154. Huang H, He X.; ''Wnt/beta-catenin signaling: new (and old) players and new insights.''; PubMed Europe PMC Scholia
155. Bafico A, Liu G, Yaniv A, Gazit A, Aaronson SA.; ''Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow.''; PubMed Europe PMC Scholia
156. Liu G, Bafico A, Harris VK, Aaronson SA.; ''A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor.''; PubMed Europe PMC Scholia
157. Kishida M, Hino Si, Michiue T, Yamamoto H, Kishida S, Fukui A, Asashima M, Kikuchi A.; ''Synergistic activation of the Wnt signaling pathway by Dvl and casein kinase Iepsilon.''; PubMed Europe PMC Scholia
158. Sinner D, Kordich JJ, Spence JR, Opoka R, Rankin S, Lin SC, Jonatan D, Zorn AM, Wells JM.; ''Sox17 and Sox4 differentially regulate beta-catenin/T-cell factor activity and proliferation of colon carcinoma cells.''; PubMed Europe PMC Scholia
159. Jho EH, Zhang T, Domon C, Joo CK, Freund JN, Costantini F.; ''Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway.''; PubMed Europe PMC Scholia
160. Bourhis E, Tam C, Franke Y, Bazan JF, Ernst J, Hwang J, Costa M, Cochran AG, Hannoush RN.; ''Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6.''; PubMed Europe PMC Scholia
161. Su Y, Fu C, Ishikawa S, Stella A, Kojima M, Shitoh K, Schreiber EM, Day BW, Liu B.; ''APC is essential for targeting phosphorylated beta-catenin to the SCFbeta-TrCP ubiquitin ligase.''; PubMed Europe PMC Scholia
162. Goodman RM, Thombre S, Firtina Z, Gray D, Betts D, Roebuck J, Spana EP, Selva EM.; ''Sprinter: a novel transmembrane protein required for Wg secretion and signaling.''; PubMed Europe PMC Scholia
163. Binnerts ME, Kim KA, Bright JM, Patel SM, Tran K, Zhou M, Leung JM, Liu Y, Lomas WE, Dixon M, Hazell SA, Wagle M, Nie WS, Tomasevic N, Williams J, Zhan X, Levy MD, Funk WD, Abo A.; ''R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6.''; PubMed Europe PMC Scholia
164. Shilatifard A.; ''Chromatin modifications by methylation and ubiquitination: implications in the regulation of gene expression.''; PubMed Europe PMC Scholia
165. Belenkaya TY, Han C, Standley HJ, Lin X, Houston DW, Heasman J, Lin X.; ''pygopus Encodes a nuclear protein essential for wingless/Wnt signaling.''; PubMed Europe PMC Scholia
166. Wolf D, Rodova M, Miska EA, Calvet JP, Kouzarides T.; ''Acetylation of beta-catenin by CREB-binding protein (CBP).''; PubMed Europe PMC Scholia
167. Feng Y, Lee N, Fearon ER.; ''TIP49 regulates beta-catenin-mediated neoplastic transformation and T-cell factor target gene induction via effects on chromatin remodeling.''; PubMed Europe PMC Scholia
168. Semënov MV, Tamai K, Brott BK, Kühl M, Sokol S, He X.; ''Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6.''; PubMed Europe PMC Scholia
169. Cong F, Varmus H.; ''Nuclear-cytoplasmic shuttling of Axin regulates subcellular localization of beta-catenin.''; PubMed Europe PMC Scholia
170. Tomson BN, Arndt KM.; ''The many roles of the conserved eukaryotic Paf1 complex in regulating transcription, histone modifications, and disease states.''; PubMed Europe PMC Scholia
171. Willert K, Nusse R.; ''Wnt proteins.''; PubMed Europe PMC Scholia
172. Behrens J, von Kries JP, Kühl M, Bruhn L, Wedlich D, Grosschedl R, Birchmeier W.; ''Functional interaction of beta-catenin with the transcription factor LEF-1.''; PubMed Europe PMC Scholia
173. Fraser E, Young N, Dajani R, Franca-Koh J, Ryves J, Williams RS, Yeo M, Webster MT, Richardson C, Smalley MJ, Pearl LH, Harwood A, Dale TC.; ''Identification of the Axin and Frat binding region of glycogen synthase kinase-3.''; PubMed Europe PMC Scholia
174. Veverka V, Henry AJ, Slocombe PM, Ventom A, Mulloy B, Muskett FW, Muzylak M, Greenslade K, Moore A, Zhang L, Gong J, Qian X, Paszty C, Taylor RJ, Robinson MK, Carr MD.; ''Characterization of the structural features and interactions of sclerostin: molecular insight into a key regulator of Wnt-mediated bone formation.''; PubMed Europe PMC Scholia
175. Mao B, Wu W, Li Y, Hoppe D, Stannek P, Glinka A, Niehrs C.; ''LDL-receptor-related protein 6 is a receptor for Dickkopf proteins.''; PubMed Europe PMC Scholia
176. Thomas GM, Frame S, Goedert M, Nathke I, Polakis P, Cohen P.; ''A GSK3-binding peptide from FRAT1 selectively inhibits the GSK3-catalysed phosphorylation of axin and beta-catenin.''; PubMed Europe PMC Scholia
177. Tago K, Nakamura T, Nishita M, Hyodo J, Nagai S, Murata Y, Adachi S, Ohwada S, Morishita Y, Shibuya H, Akiyama T.; ''Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein.''; PubMed Europe PMC Scholia
178. Brantjes H, Barker N, van Es J, Clevers H.; ''TCF: Lady Justice casting the final verdict on the outcome of Wnt signalling.''; PubMed Europe PMC Scholia
179. Valenta T, Gay M, Steiner S, Draganova K, Zemke M, Hoffmans R, Cinelli P, Aguet M, Sommer L, Basler K.; ''Probing transcription-specific outputs of β-catenin in vivo.''; PubMed Europe PMC Scholia
180. Bao R, Christova T, Song S, Angers S, Yan X, Attisano L.; ''Inhibition of tankyrases induces Axin stabilization and blocks Wnt signalling in breast cancer cells.''; PubMed Europe PMC Scholia
181. Li FQ, Mofunanya A, Harris K, Takemaru K.; ''Chibby cooperates with 14-3-3 to regulate beta-catenin subcellular distribution and signaling activity.''; PubMed Europe PMC Scholia
182. Chen G, Nguyen PH, Courey AJ.; ''A role for Groucho tetramerization in transcriptional repression.''; PubMed Europe PMC Scholia
183. Ishida-Takagishi M, Enomoto A, Asai N, Ushida K, Watanabe T, Hashimoto T, Kato T, Weng L, Matsumoto S, Asai M, Murakumo Y, Kaibuchi K, Kikuchi A, Takahashi M.; ''The Dishevelled-associating protein Daple controls the non-canonical Wnt/Rac pathway and cell motility.''; PubMed Europe PMC Scholia
184. Städeli R, Basler K.; ''Dissecting nuclear Wingless signalling: recruitment of the transcriptional co-activator Pygopus by a chain of adaptor proteins.''; PubMed Europe PMC Scholia
185. Wöhrle S, Wallmen B, Hecht A.; ''Differential control of Wnt target genes involves epigenetic mechanisms and selective promoter occupancy by T-cell factors.''; PubMed Europe PMC Scholia
186. Sakamoto I, Kishida S, Fukui A, Kishida M, Yamamoto H, Hino S, Michiue T, Takada S, Asashima M, Kikuchi A.; ''A novel beta-catenin-binding protein inhibits beta-catenin-dependent Tcf activation and axis formation.''; PubMed Europe PMC Scholia
187. Henderson BR, Fagotto F.; ''The ins and outs of APC and beta-catenin nuclear transport.''; PubMed Europe PMC Scholia
188. Brantjes H, Roose J, van De Wetering M, Clevers H.; ''All Tcf HMG box transcription factors interact with Groucho-related co-repressors.''; PubMed Europe PMC Scholia
189. Waaler J, Machon O, Tumova L, Dinh H, Korinek V, Wilson SR, Paulsen JE, Pedersen NM, Eide TJ, Machonova O, Gradl D, Voronkov A, von Kries JP, Krauss S.; ''A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice.''; PubMed Europe PMC Scholia
190. Janda CY, Waghray D, Levin AM, Thomas C, Garcia KC.; ''Structural basis of Wnt recognition by Frizzled.''; PubMed Europe PMC Scholia
191. Ferkey DM, Kimelman D.; ''Glycogen synthase kinase-3 beta mutagenesis identifies a common binding domain for GBP and Axin.''; PubMed Europe PMC Scholia
192. Sakane H, Yamamoto H, Kikuchi A.; ''LRP6 is internalized by Dkk1 to suppress its phosphorylation in the lipid raft and is recycled for reuse.''; PubMed Europe PMC Scholia
193. Farr GH, Ferkey DM, Yost C, Pierce SB, Weaver C, Kimelman D.; ''Interaction among GSK-3, GBP, axin, and APC in Xenopus axis specification.''; PubMed Europe PMC Scholia
194. Mazieres J, He B, You L, Xu Z, Lee AY, Mikami I, Reguart N, Rosell R, McCormick F, Jablons DM.; ''Wnt inhibitory factor-1 is silenced by promoter hypermethylation in human lung cancer.''; PubMed Europe PMC Scholia
195. Hoffmans R, Basler K.; ''Identification and in vivo role of the Armadillo-Legless interaction.''; PubMed Europe PMC Scholia
196. Dajani R, Fraser E, Roe SM, Yeo M, Good VM, Thompson V, Dale TC, Pearl LH.; ''Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex.''; PubMed Europe PMC Scholia
197. Davidson G, Wu W, Shen J, Bilic J, Fenger U, Stannek P, Glinka A, Niehrs C.; ''Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction.''; PubMed Europe PMC Scholia
198. Cairo S, Armengol C, Buendia MA.; ''Activation of Wnt and Myc signaling in hepatoblastoma.''; PubMed Europe PMC Scholia
199. Walf-Vorderwülbecke V, de Boer J, Horton SJ, van Amerongen R, Proost N, Berns A, Williams O.; ''Frat2 mediates the oncogenic activation of Rac by MLL fusions.''; PubMed Europe PMC Scholia
200. Arce L, Pate KT, Waterman ML.; ''Groucho binds two conserved regions of LEF-1 for HDAC-dependent repression.''; PubMed Europe PMC Scholia
201. Melichar HJ, Narayan K, Der SD, Hiraoka Y, Gardiol N, Jeannet G, Held W, Chambers CA, Kang J.; ''Regulation of gammadelta versus alphabeta T lymphocyte differentiation by the transcription factor SOX13.''; PubMed Europe PMC Scholia
202. Akiyama H, Lyons JP, Mori-Akiyama Y, Yang X, Zhang R, Zhang Z, Deng JM, Taketo MM, Nakamura T, Behringer RR, McCrea PD, de Crombrugghe B.; ''Interactions between Sox9 and beta-catenin control chondrocyte differentiation.''; PubMed Europe PMC Scholia
203. Kim S, Jho EH.; ''The protein stability of Axin, a negative regulator of Wnt signaling, is regulated by Smad ubiquitination regulatory factor 2 (Smurf2).''; PubMed Europe PMC Scholia
204. Miyazaki K, Fujita T, Ozaki T, Kato C, Kurose Y, Sakamoto M, Kato S, Goto T, Itoyama Y, Aoki M, Nakagawara A.; ''NEDL1, a novel ubiquitin-protein isopeptide ligase for dishevelled-1, targets mutant superoxide dismutase-1.''; PubMed Europe PMC Scholia
205. Cheyette BN, Waxman JS, Miller JR, Takemaru K, Sheldahl LC, Khlebtsova N, Fox EP, Earnest T, Moon RT.; ''Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation.''; PubMed Europe PMC Scholia
206. Huang SM, Mishina YM, Liu S, Cheung A, Stegmeier F, Michaud GA, Charlat O, Wiellette E, Zhang Y, Wiessner S, Hild M, Shi X, Wilson CJ, Mickanin C, Myer V, Fazal A, Tomlinson R, Serluca F, Shao W, Cheng H, Shultz M, Rau C, Schirle M, Schlegl J, Ghidelli S, Fawell S, Lu C, Curtis D, Kirschner MW, Lengauer C, Finan PM, Tallarico JA, Bouwmeester T, Porter JA, Bauer A, Cong F.; ''Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling.''; PubMed Europe PMC Scholia
207. Chen G, Fernandez J, Mische S, Courey AJ.; ''A functional interaction between the histone deacetylase Rpd3 and the corepressor groucho in Drosophila development.''; PubMed Europe PMC Scholia
208. Kim JH, Kim B, Cai L, Choi HJ, Ohgi KA, Tran C, Chen C, Chung CH, Huber O, Rose DW, Sawyers CL, Rosenfeld MG, Baek SH.; ''Transcriptional regulation of a metastasis suppressor gene by Tip60 and beta-catenin complexes.''; PubMed Europe PMC Scholia
209. Herr P, Hausmann G, Basler K.; ''WNT secretion and signalling in human disease.''; PubMed Europe PMC Scholia
210. Niehrs C, Acebron SP.; ''Wnt signaling: multivesicular bodies hold GSK3 captive.''; PubMed Europe PMC Scholia
211. Surmann-Schmitt C, Widmann N, Dietz U, Saeger B, Eitzinger N, Nakamura Y, Rattel M, Latham R, Hartmann C, von der Mark H, Schett G, von der Mark K, Stock M.; ''Wif-1 is expressed at cartilage-mesenchyme interfaces and impedes Wnt3a-mediated inhibition of chondrogenesis.''; PubMed Europe PMC Scholia
212. Kansara M, Tsang M, Tsang M, Kodjabachian L, Sims NA, Trivett MK, Ehrich M, Dobrovic A, Slavin J, Choong PF, Choong PF, Simmons PJ, Dawid IB, Thomas DM.; ''Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice.''; PubMed Europe PMC Scholia
213. Schmitt AM, Shi J, Wolf AM, Lu CC, King LA, Zou Y.; ''Wnt-Ryk signalling mediates medial-lateral retinotectal topographic mapping.''; PubMed Europe PMC Scholia
214. van Amerongen R, Nawijn M, Franca-Koh J, Zevenhoven J, van der Gulden H, Jonkers J, Berns A.; ''Frat is dispensable for canonical Wnt signaling in mammals.''; PubMed Europe PMC Scholia
215. Hino S, Michiue T, Asashima M, Kikuchi A.; ''Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of beta-catenin.''; PubMed Europe PMC Scholia
216. Willert K, Shibamoto S, Nusse R.; ''Wnt-induced dephosphorylation of axin releases beta-catenin from the axin complex.''; PubMed Europe PMC Scholia
217. Galbán S, Duckett CS.; ''XIAP as a ubiquitin ligase in cellular signaling.''; PubMed Europe PMC Scholia
218. Xing Y, Clements WK, Kimelman D, Xu W.; ''Crystal structure of a beta-catenin/axin complex suggests a mechanism for the beta-catenin destruction complex.''; PubMed Europe PMC Scholia
219. Hoffmans R, Städeli R, Basler K.; ''Pygopus and legless provide essential transcriptional coactivator functions to armadillo/beta-catenin.''; PubMed Europe PMC Scholia
220. Tamai K, Semenov M, Kato Y, Spokony R, Liu C, Katsuyama Y, Hess F, Saint-Jeannet JP, He X.; ''LDL-receptor-related proteins in Wnt signal transduction.''; PubMed Europe PMC Scholia
221. Mosimann C, Hausmann G, Basler K.; ''Parafibromin/Hyrax activates Wnt/Wg target gene transcription by direct association with beta-catenin/Armadillo.''; PubMed Europe PMC Scholia
222. Barrott JJ, Cash GM, Smith AP, Barrow JR, Murtaugh LC.; ''Deletion of mouse Porcn blocks Wnt ligand secretion and reveals an ectodermal etiology of human focal dermal hypoplasia/Goltz syndrome.''; PubMed Europe PMC Scholia
223. Kim KA, Zhao J, Andarmani S, Kakitani M, Oshima T, Binnerts ME, Abo A, Tomizuka K, Funk WD.; ''R-Spondin proteins: a novel link to beta-catenin activation.''; PubMed Europe PMC Scholia
224. Wu W, Glinka A, Delius H, Niehrs C.; ''Mutual antagonism between dickkopf1 and dickkopf2 regulates Wnt/beta-catenin signalling.''; PubMed Europe PMC Scholia
225. Lui TT, Lacroix C, Ahmed SM, Goldenberg SJ, Leach CA, Daulat AM, Angers S.; ''The ubiquitin-specific protease USP34 regulates axin stability and Wnt/β-catenin signaling.''; PubMed Europe PMC Scholia
226. Liu Y, Shi J, Lu CC, Wang ZB, Lyuksyutova AI, Song XJ, Zou Y.; ''Ryk-mediated Wnt repulsion regulates posterior-directed growth of corticospinal tract.''; PubMed Europe PMC Scholia
227. Thompson B, Townsley F, Rosin-Arbesfeld R, Musisi H, Bienz M.; ''A new nuclear component of the Wnt signalling pathway.''; PubMed Europe PMC Scholia
228. Sustmann C, Flach H, Ebert H, Eastman Q, Grosschedl R.; ''Cell-type-specific function of BCL9 involves a transcriptional activation domain that synergizes with beta-catenin.''; PubMed Europe PMC Scholia
229. van de Wetering M, Cavallo R, Dooijes D, van Beest M, van Es J, Loureiro J, Ypma A, Hursh D, Jones T, Bejsovec A, Peifer M, Mortin M, Clevers H.; ''Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF.''; PubMed Europe PMC Scholia
230. Malik HS, Eickbush TH, Goldfarb DS.; ''Evolutionary specialization of the nuclear targeting apparatus.''; PubMed Europe PMC Scholia
231. Taelman VF, Dobrowolski R, Plouhinec JL, Fuentealba LC, Vorwald PP, Gumper I, Sabatini DD, De Robertis EM.; ''Wnt signaling requires sequestration of glycogen synthase kinase 3 inside multivesicular endosomes.''; PubMed Europe PMC Scholia
232. Bänziger C, Soldini D, Schütt C, Zipperlen P, Hausmann G, Basler K.; ''Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells.''; PubMed Europe PMC Scholia
233. Wong HC, Bourdelas A, Krauss A, Lee HJ, Shao Y, Wu D, Mlodzik M, Shi DL, Zheng J.; ''Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled.''; PubMed Europe PMC Scholia
234. Li L, Mao J, Sun L, Liu W, Wu D.; ''Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled.''; PubMed Europe PMC Scholia
235. Zorn AM, Barish GD, Williams BO, Lavender P, Klymkowsky MW, Varmus HE.; ''Regulation of Wnt signaling by Sox proteins: XSox17 alpha/beta and XSox3 physically interact with beta-catenin.''; PubMed Europe PMC Scholia
236. Cong F, Schweizer L, Varmus H.; ''Wnt signals across the plasma membrane to activate the beta-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP.''; PubMed Europe PMC Scholia
237. Niehrs C.; ''Function and biological roles of the Dickkopf family of Wnt modulators.''; PubMed Europe PMC Scholia
238. Yost C, Farr GH, Pierce SB, Ferkey DM, Chen MM, Kimelman D.; ''GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis.''; PubMed Europe PMC Scholia
239. Fiedler M, Sánchez-Barrena MJ, Nekrasov M, Mieszczanek J, Rybin V, Müller J, Evans P, Bienz M.; ''Decoding of methylated histone H3 tail by the Pygo-BCL9 Wnt signaling complex.''; PubMed Europe PMC Scholia
240. Neufeld KL.; ''Nuclear APC.''; PubMed Europe PMC Scholia
241. Thompson BA, Tremblay V, Lin G, Bochar DA.; ''CHD8 is an ATP-dependent chromatin remodeling factor that regulates beta-catenin target genes.''; PubMed Europe PMC Scholia
242. Omer CA, Miller PJ, Diehl RE, Kral AM.; ''Identification of Tcf4 residues involved in high-affinity beta-catenin binding.''; PubMed Europe PMC Scholia
243. Mao B, Wu W, Davidson G, Marhold J, Li M, Mechler BM, Delius H, Hoppe D, Stannek P, Walter C, Glinka A, Niehrs C.; ''Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling.''; PubMed Europe PMC Scholia
244. Parker DS, Ni YY, Chang JL, Li J, Cadigan KM.; ''Wingless signaling induces widespread chromatin remodeling of target loci.''; PubMed Europe PMC Scholia
245. Luo W, Peterson A, Garcia BA, Coombs G, Kofahl B, Heinrich R, Shabanowitz J, Hunt DF, Yost HJ, Virshup DM.; ''Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex.''; PubMed Europe PMC Scholia
246. Lin YC, You L, Xu Z, He B, Mikami I, Thung E, Chou J, Kuchenbecker K, Kim J, Raz D, Yang CT, Chen JK, Jablons DM.; ''Wnt signaling activation and WIF-1 silencing in nasopharyngeal cancer cell lines.''; PubMed Europe PMC Scholia
247. Bernard P, Sim H, Knower K, Vilain E, Harley V.; ''Human SRY inhibits beta-catenin-mediated transcription.''; PubMed Europe PMC Scholia
248. Chen S, Bubeck D, MacDonald BT, Liang WX, Mao JH, Malinauskas T, Llorca O, Aricescu AR, Siebold C, He X, Jones EY.; ''Structural and functional studies of LRP6 ectodomain reveal a platform for Wnt signaling.''; PubMed Europe PMC Scholia
249. Jessen S, Gu B, Dai X.; ''Pygopus and the Wnt signaling pathway: a diverse set of connections.''; PubMed Europe PMC Scholia
250. Song H, Hasson P, Paroush Z, Courey AJ.; ''Groucho oligomerization is required for repression in vivo.''; PubMed Europe PMC Scholia
251. Barker N, Hurlstone A, Musisi H, Miles A, Bienz M, Clevers H.; ''The chromatin remodelling factor Brg-1 interacts with beta-catenin to promote target gene activation.''; PubMed Europe PMC Scholia
252. Willis TG, Zalcberg IR, Coignet LJ, Wlodarska I, Stul M, Jadayel DM, Bastard C, Treleaven JG, Catovsky D, Silva ML, Dyer MJ.; ''Molecular cloning of translocation t(1;14)(q21;q32) defines a novel gene (BCL9) at chromosome 1q21.''; PubMed Europe PMC Scholia
253. Gu B, Watanabe K, Dai X.; ''Pygo2 regulates histone gene expression and H3 K56 acetylation in human mammary epithelial cells.''; PubMed Europe PMC Scholia

History

External references

DataNodes

Name	Type	Database reference	Comment
26S proteasome	Complex	R-HSA-68819 (Reactome)
ADP	Metabolite	CHEBI:16761 (ChEBI)
AMER1	Protein	Q5JTC6 (Uniprot-TrEMBL)
AMER1	Protein	Q5JTC6 (Uniprot-TrEMBL)
APC	Protein	P25054 (Uniprot-TrEMBL)
APC:CTBP:CTNNB1:BTRC	Complex	R-HSA-3361756 (Reactome)
APC	Protein	P25054 (Uniprot-TrEMBL)
ASH2L	Protein	Q9UBL3 (Uniprot-TrEMBL)
ASH2L	Protein	Q9UBL3 (Uniprot-TrEMBL)
ATP	Metabolite	CHEBI:15422 (ChEBI)
AXIN1	Protein	O15169 (Uniprot-TrEMBL)
AXIN2	Protein	Q9Y2T1 (Uniprot-TrEMBL)
AXIN2 gene	Protein	ENSG00000168646 (ENSEMBL)
AXIN2 gene		ENSG00000168646 (ENSEMBL)
AXIN2	Protein	Q9Y2T1 (Uniprot-TrEMBL)
AXIN:SMURF2	Complex	R-HSA-4641136 (Reactome)
AXIN:TNKS	Complex	R-HSA-3640822 (Reactome)
AXIN		R-HSA-3640819 (Reactome)
Ac-CoA	Metabolite	CHEBI:15351 (ChEBI)
AcK-HIST1H4	Protein	P62805 (Uniprot-TrEMBL)
AdoHcy	Metabolite	CHEBI:16680 (ChEBI)
AdoMet	Metabolite	CHEBI:15414 (ChEBI)
BCL9	Protein	O00512 (Uniprot-TrEMBL)
BCL9L	Protein	Q86UU0 (Uniprot-TrEMBL)
BCL9		R-HSA-3305844 (Reactome)
BTRC	Protein	Q9Y297 (Uniprot-TrEMBL)
BTRC	Protein	Q9Y297 (Uniprot-TrEMBL)
CAV1	Protein	Q03135 (Uniprot-TrEMBL)
CBP/p300		R-HSA-1027362 (Reactome)
CBY1	Protein	Q9Y3M2 (Uniprot-TrEMBL)
CBY1:CTNNB1	Complex	R-HSA-3769380 (Reactome)
CBY1	Protein	Q9Y3M2 (Uniprot-TrEMBL)
CCDC88C	Protein	Q9P219 (Uniprot-TrEMBL)
CCDC88C	Protein	Q9P219 (Uniprot-TrEMBL)
CDC73	Protein	Q6P1J9 (Uniprot-TrEMBL)
CDC73	Protein	Q6P1J9 (Uniprot-TrEMBL)
CHD8	Protein	Q9HCK8 (Uniprot-TrEMBL)
CHD8	Protein	Q9HCK8 (Uniprot-TrEMBL)
CREBBP	Protein	Q92793 (Uniprot-TrEMBL)
CSNK1A1	Protein	P48729 (Uniprot-TrEMBL)
CSNK1A1	Protein	P48729 (Uniprot-TrEMBL)
CSNK1E	Protein	P49674 (Uniprot-TrEMBL)
CSNK1G2	Protein	P78368 (Uniprot-TrEMBL)
CSNK2A1	Protein	P68400 (Uniprot-TrEMBL)
CSNK2A2	Protein	P19784 (Uniprot-TrEMBL)
CSNK2B	Protein	P67870 (Uniprot-TrEMBL)
CTBP1	Protein	Q13363 (Uniprot-TrEMBL)
CTBP1	Protein	Q13363 (Uniprot-TrEMBL)
CTNNB1	Protein	P35222 (Uniprot-TrEMBL)
CTNNB1:AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex	Complex	R-HSA-4416737 (Reactome)
CTNNB1:CHD8	Complex	R-HSA-5368504 (Reactome)
CTNNB1:SRY,SOX2,SOX3,SOX4,SOX6,SOX7,SOX9,SOX17	Complex	R-HSA-5626915 (Reactome)
CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex	Complex	R-HSA-3601581 (Reactome)
CTNNB1	Protein	P35222 (Uniprot-TrEMBL)
CTNNBIP1	Protein	Q9NSA3 (Uniprot-TrEMBL)
CTNNBIP1:CTNNB1	Complex	R-HSA-3772415 (Reactome)
CTNNBIP1	Protein	Q9NSA3 (Uniprot-TrEMBL)
CUL3	Protein	Q13618 (Uniprot-TrEMBL)
CUL3:KLHL12:RBX1	Complex	R-HSA-1504195 (Reactome)
CXXC4	Protein	Q9H2H0 (Uniprot-TrEMBL)
CXXC4	Protein	Q9H2H0 (Uniprot-TrEMBL)
Casein kinase II	Complex	R-HSA-201711 (Reactome)
CoA-SH	Metabolite	CHEBI:15346 (ChEBI)
DACT1	Protein	Q9NYF0 (Uniprot-TrEMBL)
DACT1	Protein	Q9NYF0 (Uniprot-TrEMBL)
DKK		R-HSA-3769325 (Reactome)
DVL1	Protein	O14640 (Uniprot-TrEMBL)
DVL1:HECW1	Complex	R-HSA-4641154 (Reactome)
DVL1	Protein	O14640 (Uniprot-TrEMBL)
DVL2	Protein	O14641 (Uniprot-TrEMBL)
DVL2:DACT1	Complex	R-HSA-4641149 (Reactome)
DVL2	Protein	O14641 (Uniprot-TrEMBL)
DVL:CCDC88C	Complex	R-HSA-5368505 (Reactome)
DVL:CUL3:KLHL12:RBX1	Complex	R-HSA-1504210 (Reactome)
DVL:CXXC4	Complex	R-HSA-5368508 (Reactome)
DVL		R-HSA-1504201 (Reactome)
DVL		R-HSA-201725 (Reactome)
Degradation of beta-catenin by the destruction complex	Pathway	R-HSA-195253 (Reactome)	The beta-catenin destruction complex plays a key role in the canonical Wnt signaling pathway. In the absence of Wnt signaling, this complex controls the levels of cytoplamic beta-catenin. Beta-catenin associates with and is phosphorylated by the destruction complex. Phosphorylated beta-catenin is recognized and ubiquitinated by the SCF-beta TrCP ubiquitin ligase complex and is subsequently degraded by the proteasome (reviewed in Kimelman and Xu, 2006).
EP300	Protein	Q09472 (Uniprot-TrEMBL)
FRAT1	Protein	Q92837 (Uniprot-TrEMBL)
FRAT1,2:GSK3beta	Complex	R-HSA-1226052 (Reactome)
FRAT1,2		R-HSA-1226058 (Reactome)
FRAT2	Protein	O75474 (Uniprot-TrEMBL)
FZD1	Protein	Q9UP38 (Uniprot-TrEMBL)
FZD2	Protein	Q14332 (Uniprot-TrEMBL)
FZD5	Protein	Q13467 (Uniprot-TrEMBL)
GSK3B	Protein	P49841 (Uniprot-TrEMBL)
GSK3B:AXIN1	Complex	R-HSA-1504204 (Reactome)
GSK3B	Protein	P49841 (Uniprot-TrEMBL)
H2O	Metabolite	CHEBI:15377 (ChEBI)
HDAC1	Protein	Q13547 (Uniprot-TrEMBL)
HDAC1	Protein	Q13547 (Uniprot-TrEMBL)
HECW1	Protein	Q76N89 (Uniprot-TrEMBL)
HECW1	Protein	Q76N89 (Uniprot-TrEMBL)
HIST1H4	Protein	P62805 (Uniprot-TrEMBL)
HIST3H3	Protein	Q16695 (Uniprot-TrEMBL)
K63 ub-APC	Protein	P25054 (Uniprot-TrEMBL)
K63 ub-APC	Protein	P25054 (Uniprot-TrEMBL)
KAT5	Protein	Q92993 (Uniprot-TrEMBL)
KAT5	Protein	Q92993 (Uniprot-TrEMBL)
KLHL12	Protein	Q53G59 (Uniprot-TrEMBL)
KMT2D	Protein	O14686 (Uniprot-TrEMBL)
KMT2D	Protein	O14686 (Uniprot-TrEMBL)
KRM1/2		R-HSA-3769333 (Reactome)
KRM:DKK:LRP5/6	Complex	R-HSA-3769399 (Reactome)
KRM:DKK:LRP5/6	Complex	R-HSA-5368514 (Reactome)
LEF1	Protein	Q9UJU2 (Uniprot-TrEMBL)
LEO1	Protein	Q8WVC0 (Uniprot-TrEMBL)
LEO1	Protein	Q8WVC0 (Uniprot-TrEMBL)
LGR4	Protein	Q9BXB1 (Uniprot-TrEMBL)
LGR5	Protein	O75473 (Uniprot-TrEMBL)
LGR6	Protein	Q9HBX8 (Uniprot-TrEMBL)
LGR		R-HSA-4641170 (Reactome)
LRP5/6		R-HSA-201719 (Reactome)
MEN1	Protein	O00255 (Uniprot-TrEMBL)
MEN1	Protein	O00255 (Uniprot-TrEMBL)
MYC Gene	Protein	ENSG00000136997 (ENSEMBL)
MYC Gene		ENSG00000136997 (ENSEMBL)
MYC gene: H2B K121ub nucleosome	Complex	R-HSA-3364023 (Reactome)
MYC gene:H2B K121ub H3K4me3 nucleosome	Complex	R-HSA-3364034 (Reactome)
MYC	Protein	P01106 (Uniprot-TrEMBL)
N4GlycoAsn-PalmS WNT1	Protein	P04628 (Uniprot-TrEMBL)
N4GlycoAsn-PalmS WNT3	Protein	P56703 (Uniprot-TrEMBL)
N4GlycoAsn-PalmS WNT3A	Protein	P56704 (Uniprot-TrEMBL)
N4GlycoAsn-PalmS WNT3A	Protein	P56704 (Uniprot-TrEMBL)
N4GlycoAsn-PalmS WNT4	Protein	P56705 (Uniprot-TrEMBL)
N4GlycoAsn-PalmS WNT5A(36-380)	Protein	P41221 (Uniprot-TrEMBL)
N4GlycoAsn-PalmS WNT8A	Protein	Q9H1J5 (Uniprot-TrEMBL)
N4GlycoAsn-PalmS WNT8B	Protein	Q93098 (Uniprot-TrEMBL)
N4GlycoAsn-PalmS WNT9A	Protein	O14904 (Uniprot-TrEMBL)
N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6:ZNRF3/RNF43	Complex	R-HSA-4641177 (Reactome)
N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6	Complex	R-HSA-4641176 (Reactome)
N4GlycoAsn-PalmS-WNT3A:ub-FZD:LRP5/6:ZNRF3/RNF43	Complex	R-HSA-4641191 (Reactome)
N4GlycoAsn-PalmS-WNT3A:ub-FZD:LRP5/6	Complex	R-HSA-4641185 (Reactome)
NAD+	Metabolite	CHEBI:15846 (ChEBI)
NAM	Metabolite	CHEBI:17154 (ChEBI)
PI(4,5)P2	Metabolite	CHEBI:18348 (ChEBI)
PI4P	Metabolite	CHEBI:17526 (ChEBI)
PIP5K1B	Protein	O14986 (Uniprot-TrEMBL)
PIP5K1B	Protein	O14986 (Uniprot-TrEMBL)
PP2A	Complex	R-HSA-196206 (Reactome)
PSMA1	Protein	P25786 (Uniprot-TrEMBL)
PSMA2	Protein	P25787 (Uniprot-TrEMBL)
PSMA3	Protein	P25788 (Uniprot-TrEMBL)
PSMA4	Protein	P25789 (Uniprot-TrEMBL)
PSMA5	Protein	P28066 (Uniprot-TrEMBL)
PSMA6	Protein	P60900 (Uniprot-TrEMBL)
PSMA7	Protein	O14818 (Uniprot-TrEMBL)
PSMA8	Protein	Q8TAA3 (Uniprot-TrEMBL)
PSMB1	Protein	P20618 (Uniprot-TrEMBL)
PSMB10	Protein	P40306 (Uniprot-TrEMBL)
PSMB11	Protein	A5LHX3 (Uniprot-TrEMBL)
PSMB2	Protein	P49721 (Uniprot-TrEMBL)
PSMB3	Protein	P49720 (Uniprot-TrEMBL)
PSMB4	Protein	P28070 (Uniprot-TrEMBL)
PSMB5	Protein	P28074 (Uniprot-TrEMBL)
PSMB6	Protein	P28072 (Uniprot-TrEMBL)
PSMB7	Protein	Q99436 (Uniprot-TrEMBL)
PSMB8	Protein	P28062 (Uniprot-TrEMBL)
PSMB9	Protein	P28065 (Uniprot-TrEMBL)
PSMC1	Protein	P62191 (Uniprot-TrEMBL)
PSMC2	Protein	P35998 (Uniprot-TrEMBL)
PSMC3	Protein	P17980 (Uniprot-TrEMBL)
PSMC4	Protein	P43686 (Uniprot-TrEMBL)
PSMC5	Protein	P62195 (Uniprot-TrEMBL)
PSMC6	Protein	P62333 (Uniprot-TrEMBL)
PSMD1	Protein	Q99460 (Uniprot-TrEMBL)
PSMD10	Protein	O75832 (Uniprot-TrEMBL)
PSMD11	Protein	O00231 (Uniprot-TrEMBL)
PSMD12	Protein	O00232 (Uniprot-TrEMBL)
PSMD13	Protein	Q9UNM6 (Uniprot-TrEMBL)
PSMD14	Protein	O00487 (Uniprot-TrEMBL)
PSMD2	Protein	Q13200 (Uniprot-TrEMBL)
PSMD3	Protein	O43242 (Uniprot-TrEMBL)
PSMD4	Protein	P55036 (Uniprot-TrEMBL)
PSMD5	Protein	Q16401 (Uniprot-TrEMBL)
PSMD6	Protein	Q15008 (Uniprot-TrEMBL)
PSMD7	Protein	P51665 (Uniprot-TrEMBL)
PSMD8	Protein	P48556 (Uniprot-TrEMBL)
PSMD9	Protein	O00233 (Uniprot-TrEMBL)
PSME1	Protein	Q06323 (Uniprot-TrEMBL)
PSME2	Protein	Q9UL46 (Uniprot-TrEMBL)
PSME3	Protein	P61289 (Uniprot-TrEMBL)
PSME4	Protein	Q14997 (Uniprot-TrEMBL)
PSMF1	Protein	Q92530 (Uniprot-TrEMBL)
PYGO1	Protein	Q9Y3Y4 (Uniprot-TrEMBL)
PYGO2	Protein	Q9BRQ0 (Uniprot-TrEMBL)
PYGO		R-HSA-3322379 (Reactome)
RBBP5	Protein	Q15291 (Uniprot-TrEMBL)
RBBP5	Protein	Q15291 (Uniprot-TrEMBL)
RBX1	Protein	P62877 (Uniprot-TrEMBL)
RNF146	Protein	Q9NTX7 (Uniprot-TrEMBL)
RNF146	Protein	Q9NTX7 (Uniprot-TrEMBL)
RNF43	Protein	Q68DV7 (Uniprot-TrEMBL)
RSPO1	Protein	Q2MKA7 (Uniprot-TrEMBL)
RSPO2	Protein	Q6UXX9 (Uniprot-TrEMBL)
RSPO3	Protein	Q9BXY4 (Uniprot-TrEMBL)
RSPO4	Protein	Q2I0M5 (Uniprot-TrEMBL)
RSPO:LGR:ZNRF3/RNF43	Complex	R-HSA-4641203 (Reactome)
RSPO:LGR:ub-ZNRF3/RNF43	Complex	R-HSA-4641211 (Reactome)
RSPO:LGR	Complex	R-HSA-4641201 (Reactome)
RSPO		R-HSA-4641198 (Reactome)
RUVBL1	Protein	Q9Y265 (Uniprot-TrEMBL)
RUVBL1	Protein	Q9Y265 (Uniprot-TrEMBL)
RYK	Protein	P34925 (Uniprot-TrEMBL)
RYK-binding WNTs		R-HSA-5323535 (Reactome)
RYK:WNTs	Complex	R-HSA-5323537 (Reactome)
RYK	Protein	P34925 (Uniprot-TrEMBL)
RibC-AXIN1	Protein	O15169 (Uniprot-TrEMBL)
RibC-AXIN2	Protein	Q9Y2T1 (Uniprot-TrEMBL)
RibC-AXIN:TNKS:RNF146	Complex	R-HSA-3640845 (Reactome)
RibC-AXIN:TNKS	Complex	R-HSA-3772504 (Reactome)
SFRP1	Protein	Q8N474 (Uniprot-TrEMBL)
SFRP2	Protein	Q96HF1 (Uniprot-TrEMBL)
SMARCA4	Protein	P51532 (Uniprot-TrEMBL)
SMARCA4	Protein	P51532 (Uniprot-TrEMBL)
SMURF2	Protein	Q9HAU4 (Uniprot-TrEMBL)
SMURF2	Protein	Q9HAU4 (Uniprot-TrEMBL)
SOST	Protein	Q9BQB4 (Uniprot-TrEMBL)
SOST:LRP5/6	Complex	R-HSA-3769334 (Reactome)
SOST	Protein	Q9BQB4 (Uniprot-TrEMBL)
SOX13	Protein	Q9UN79 (Uniprot-TrEMBL)
SOX17	Protein	Q9H6I2 (Uniprot-TrEMBL)
SOX2	Protein	P48431 (Uniprot-TrEMBL)
SOX3	Protein	P41225 (Uniprot-TrEMBL)
SOX4	Protein	Q06945 (Uniprot-TrEMBL)
SOX4,SOX13,SOX17		R-HSA-5665611 (Reactome)
SOX6	Protein	P35712 (Uniprot-TrEMBL)
SOX7	Protein	Q9BT81 (Uniprot-TrEMBL)
SOX9	Protein	P48436 (Uniprot-TrEMBL)
SRY	Protein	Q05066 (Uniprot-TrEMBL)
SRY,SOX2,SOX3,SOX4,SOX6,SOX7,SOX9,SOX17		R-HSA-5626912 (Reactome)
TCF/LEF:CTNNB1:APC:CTBP:BTRC	Complex	R-HSA-3361754 (Reactome)
TCF/LEF:CTNNB1:AXIN2 gene	Complex	R-HSA-4411391 (Reactome)
TCF/LEF:CTNNB1:BCL9:PYGO:SET1-like complex	Complex	R-HSA-3361369 (Reactome)
TCF/LEF:CTNNB1:BCL9:PYGO	Complex	R-HSA-201917 (Reactome)
TCF/LEF:CTNNB1:CBP/p300	Complex	R-HSA-3322396 (Reactome)
TCF/LEF:CTNNB1:PAF1-like complex	Complex	R-HSA-3322393 (Reactome)
TCF/LEF:CTNNB1:RUVBL1:TRRAP:KAT5	Complex	R-HSA-3451129 (Reactome)
TCF/LEF:CTNNB1:SMARCA4:TERT	Complex	R-HSA-3322391 (Reactome)
TCF/LEF:CTNNB1:SOX4,SOX13,SOX17	Complex	R-HSA-5665607 (Reactome)
TCF/LEF:CTNNB1	Complex	R-HSA-3299548 (Reactome)
TCF/LEF:CTNNB1	Complex	R-HSA-4411394 (Reactome)
TCF/LEF:TLE:HDAC1	Complex	R-HSA-3299555 (Reactome)
TCF4 gene	Protein	ENSG00000196628 (ENSEMBL)
TCF4 gene:acetyl H4 nucleosome	Complex	R-HSA-3451134 (Reactome)
TCF4 gene:nucleosome	Complex	R-HSA-3451116 (Reactome)
TCF7	Protein	P36402 (Uniprot-TrEMBL)
TCF7L1	Protein	Q9HCS4 (Uniprot-TrEMBL)
TCF7L1/TCF7L2/LEF1:CTNNB1:MYC gene	Complex	R-HSA-4411387 (Reactome)
TCF7L1/TCF7L2/LEF1:CTNNB1	Complex	R-HSA-4411378 (Reactome)
TCF7L2	Protein	Q9NQB0 (Uniprot-TrEMBL)
TERT	Protein	O14746 (Uniprot-TrEMBL)
TERT	Protein	O14746 (Uniprot-TrEMBL)
TLE tetramer		R-HSA-3299565 (Reactome)
TLE1	Protein	Q04724 (Uniprot-TrEMBL)
TLE1:HDAC1	Complex	R-HSA-3299553 (Reactome)
TLE2	Protein	Q04725 (Uniprot-TrEMBL)
TLE3	Protein	Q04726 (Uniprot-TrEMBL)
TLE4	Protein	Q04727 (Uniprot-TrEMBL)
TLE:XIAP	Complex	R-HSA-3322390 (Reactome)
TNKS	Protein	O95271 (Uniprot-TrEMBL)
TNKS1/2:XAV939	Complex	R-HSA-5262603 (Reactome)
TNKS1/2		R-HSA-3640826 (Reactome)
TNKS2	Protein	Q9H2K2 (Uniprot-TrEMBL)
TRRAP	Protein	Q9Y4A5 (Uniprot-TrEMBL)
TRRAP	Protein	Q9Y4A5 (Uniprot-TrEMBL)
USP34	Protein	Q70CQ2 (Uniprot-TrEMBL)
USP8	Protein	P40818 (Uniprot-TrEMBL)
Ub-RibC-AXIN1	Protein	O15169 (Uniprot-TrEMBL)
Ub-RibC-AXIN2	Protein	Q9Y2T1 (Uniprot-TrEMBL)
Ub-RibC-AXIN:TNKS:RNF146	Complex	R-HSA-3640854 (Reactome)
Ub-TLE1	Protein	Q04724 (Uniprot-TrEMBL)
Ub-TLE2	Protein	Q04725 (Uniprot-TrEMBL)
Ub-TLE3	Protein	Q04726 (Uniprot-TrEMBL)
Ub-TLE4	Protein	Q04727 (Uniprot-TrEMBL)
Ub		R-HSA-113595 (Reactome)
WIF1	Protein	Q9Y5W5 (Uniprot-TrEMBL)
WIF1-binding WNTs		R-HSA-3769336 (Reactome)
WIF1:WNT	Complex	R-HSA-3769337 (Reactome)
WIF1	Protein	Q9Y5W5 (Uniprot-TrEMBL)
WNT ligand biogenesis and trafficking	Pathway	R-HSA-3238698 (Reactome)	19 WNT proteins have been identified in human cells. The WNTs are members of a conserved metazoan family of secreted morphogens that activate several signaling pathways in the responding cell: the canonical (beta-catenin) WNT signaling cascade and several non-canonical pathways, including the planar cell polarity (PCP), the regulation of intracellular calcium signaling and activation of JNK kinases. WNT proteins exist in a gradient outside the secreting cell and are able to act over both short and long ranges to promote proliferation, changes in cell migration and polarity and tissue homeostasis, among others (reviewed in Saito-Diaz et al, 2012; Willert and Nusse, 2012). The WNTs are ~40kDa proteins with 23 conserved cysteine residues in the N-terminal that may form intramolecular disulphide bonds. They also contain an N-terminal signal sequence and a number of N-linked glycosylation sites (Janda et al, 2012). In addition to being glycosylated, WNTs are also lipid-modified in the endoplasmic reticulum by a WNT-specific O-acyl-transferase, Porcupine (PORCN), contributing to their characteristic hydrophobicity. PORCN-dependent palmitoylation is required for the secretion of WNT as well as its signaling activity, as either depletion of PORCN or mutation of the conserved serine acylation site results in the intracellular accumulation of WNT ligand (Takada et al, 2006; Barrott et al, 2011; Biechele et al, 2011; reviewed in Willert and Nusse, 2012). Secretion of WNT requires a number of other dedicated factors including the sorting receptor Wntless (WLS) (also knownas Evi, Sprinter, and GPR177), which binds WNT and escorts it to the cell surface (Banziger et al, 2006; Bartscherer et al, 2006; Goodman et al, 2006). A WNT-specific retromer containing SNX3 is subsequently required for the recycling of WLS back to the Golgi (reviewed in Herr et al, 2012; Johannes and Wunder, 2011). Once at the cell surface, WNT makes extensive contacts with components of the extracellular matrix such as heparan sulphate proteoglycans (HSPGs) and may be bound by any of a number of regulatory proteins, including WIFs and SFRPs. The diffusion of the WNT ligand may be aided by its packing either into WNT multimers, exosomes or onto lipoprotein particles to shield the hydrophobic lipid adducts from the aqueous extracellular environment (Gross et al, 2012; Luga et al, 2012, Korkut et al, 2009; reviewed in Willert and Nusse, 2012).
WNT3A:FZD5:p-LRP6:GSK3B:AXIN:CAV1	Complex	R-HSA-5368519 (Reactome)
WNT3A:FZD5:p-LRP6:GSK3B:AXIN:CAV1	Complex	R-HSA-5368521 (Reactome)
WNT3A:sFRP	Complex	R-HSA-3772418 (Reactome)
WNT:FZD:LRP5/6:DVL:AXIN:GSK3B	Complex	R-HSA-1504184 (Reactome)
WNT:FZD:LRP5/6:DVL	Complex	R-HSA-1504192 (Reactome)
WNT:FZD:LRP5/6	Complex	R-HSA-1458876 (Reactome)
WNT:FZD:p10S/T-LRP5/6:DVL:AXIN:GSK3B	Complex	R-HSA-1458890 (Reactome)
WNT:FZD:p5S/T-LRP5/6:DVL:AXIN:GSK3B	Complex	R-HSA-1458897 (Reactome)
XAV939	Metabolite	CHEBI:62878 (ChEBI)
XAV939	Metabolite	CHEBI:62878 (ChEBI)
XIAP	Protein	P98170 (Uniprot-TrEMBL)
XIAP	Protein	P98170 (Uniprot-TrEMBL)
XPO1	Protein	O14980 (Uniprot-TrEMBL)
XPO1:YWHAZ:p-S20-CBY1:CTNNB1	Complex	R-HSA-3769387 (Reactome)
XPO1:YWHAZ:p-S20-CBY1:CTNNB1	Complex	R-HSA-3769388 (Reactome)
XPO1	Protein	O14980 (Uniprot-TrEMBL)
YWHAZ	Protein	P63104 (Uniprot-TrEMBL)
YWHAZ:p-S20-CBY:CTNNB1	Complex	R-HSA-3769389 (Reactome)
YWHAZ	Protein	P63104 (Uniprot-TrEMBL)
ZNRF3	Protein	Q9ULT6 (Uniprot-TrEMBL)
ZNRF3/RNF43		R-HSA-5323542 (Reactome)
canonical FZD receptors		R-HSA-1504202 (Reactome)
canonical WNTs		R-HSA-1504197 (Reactome)
p-2S,S1490,2T-LRP6	Protein	O75581 (Uniprot-TrEMBL)
p-3S,2T-LRP5	Protein	O75197 (Uniprot-TrEMBL)
p-4S,3T,T1479,S1490,T1493-LRP6	Protein	O75581 (Uniprot-TrEMBL)
p-5S,5T-LRP5	Protein	O75197 (Uniprot-TrEMBL)
p-AKT1/2		R-HSA-3769360 (Reactome)
p-DVL		R-HSA-201689 (Reactome)
p-LRP6	Protein	O75581 (Uniprot-TrEMBL)
p-T519,S524,S531-AXIN1	Protein	O15169 (Uniprot-TrEMBL)
pS20-CBY1	Protein	Q9Y3M2 (Uniprot-TrEMBL)
pS20-CBY1:CTNNB1	Complex	R-HSA-3769358 (Reactome)
pp-DVL1	Protein	O14640 (Uniprot-TrEMBL)
pp-DVL2	Protein	O14641 (Uniprot-TrEMBL)
pp-DVL3	Protein	Q92997 (Uniprot-TrEMBL)
pp-DVL		R-HSA-3772407 (Reactome)
ppDVL:PIP5K1B	Complex	R-HSA-3772421 (Reactome)
sFRP		R-HSA-3772405 (Reactome)
ub-AXIN1	Protein	O15169 (Uniprot-TrEMBL)
ub-AXIN2	Protein	Q9Y2T1 (Uniprot-TrEMBL)
ub-AXIN:SMURF2	Complex	R-HSA-4641139 (Reactome)
ub-DVL1	Protein	O14640 (Uniprot-TrEMBL)
ub-DVL1:HECW1	Complex	R-HSA-4641160 (Reactome)
ub-DVL:CUL3:KLHL12:RBX1	Complex	R-HSA-4652690 (Reactome)
ub-RNF43	Protein	Q68DV7 (Uniprot-TrEMBL)
ub-TLE:XIAP	Complex	R-HSA-3322386 (Reactome)
ub-TLE		R-HSA-3322385 (Reactome)
ub-ZNRF3	Protein	Q9ULT6 (Uniprot-TrEMBL)
ubiquitin		R-HSA-68524 (Reactome)