Mitotic G1 phase and G1/S transition (Homo sapiens)
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- Sun P, Yoshizuka N, New L, Moser BA, Li Y, Liao R, Xie C, Chen J, Deng Q, Yamout M, Dong MQ, Frangou CG, Yates JR, Wright PE, Han J.; ''PRAK is essential for ras-induced senescence and tumor suppression.''; PubMed Europe PMC Scholia
- Chen CR, Kang Y, Siegel PM, Massagué J.; ''E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression.''; PubMed Europe PMC Scholia
- Ichijo H, Nishida E, Irie K, ten Dijke P, Saitoh M, Moriguchi T, Takagi M, Matsumoto K, Miyazono K, Gotoh Y.; ''Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways.''; PubMed Europe PMC Scholia
- Derry JJ, Richard S, Valderrama Carvajal H, Ye X, Vasioukhin V, Cochrane AW, Chen T, Tyner AL.; ''Sik (BRK) phosphorylates Sam68 in the nucleus and negatively regulates its RNA binding ability.''; PubMed Europe PMC Scholia
- Murphy LO, Smith S, Chen RH, Fingar DC, Blenis J.; ''Molecular interpretation of ERK signal duration by immediate early gene products.''; PubMed Europe PMC Scholia
- Guan KL, Jenkins CW, Li Y, O'Keefe CL, Noh S, Wu X, Zariwala M, Matera AG, Xiong Y.; ''Isolation and characterization of p19INK4d, a p16-related inhibitor specific to CDK6 and CDK4.''; PubMed Europe PMC Scholia
- Barradas M, Anderton E, Acosta JC, Li S, Banito A, Rodriguez-Niedenführ M, Maertens G, Banck M, Zhou MM, Walsh MJ, Peters G, Gil J.; ''Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS.''; PubMed Europe PMC Scholia
- Watanabe N, Broome M, Hunter T.; ''Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle.''; PubMed Europe PMC Scholia
- New L, Jiang Y, Han J.; ''Regulation of PRAK subcellular location by p38 MAP kinases.''; PubMed Europe PMC Scholia
- Ferreira R, Magnaghi-Jaulin L, Robin P, Harel-Bellan A, Trouche D.; ''The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase.''; PubMed Europe PMC Scholia
- Glover JN, Harrison SC.; ''Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA.''; PubMed Europe PMC Scholia
- Borriello A, Caldarelli I, Bencivenga D, Cucciolla V, Oliva A, Usala E, Danise P, Ronzoni L, Perrotta S, Della Ragione F.; ''p57Kip2 is a downstream effector of BCR-ABL kinase inhibitors in chronic myelogenous leukemia cells.''; PubMed Europe PMC Scholia
- Baek KH, Ryeom S.; ''Detection of Oncogene-Induced Senescence In Vivo.''; PubMed Europe PMC Scholia
- Hao B, Zheng N, Schulman BA, Wu G, Miller JJ, Pagano M, Pavletich NP.; ''Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase.''; PubMed Europe PMC Scholia
- Zacksenhaus E, Bremner R, Phillips RA, Gallie BL.; ''A bipartite nuclear localization signal in the retinoblastoma gene product and its importance for biological activity.''; PubMed Europe PMC Scholia
- Blain SW, Montalvo E, Massagué J.; ''Differential interaction of the cyclin-dependent kinase (Cdk) inhibitor p27Kip1 with cyclin A-Cdk2 and cyclin D2-Cdk4.''; PubMed Europe PMC Scholia
- Bisteau X, Paternot S, Colleoni B, Ecker K, Coulonval K, De Groote P, Declercq W, Hengst L, Roger PP.; ''CDK4 T172 phosphorylation is central in a CDK7-dependent bidirectional CDK4/CDK2 interplay mediated by p21 phosphorylation at the restriction point.''; PubMed Europe PMC Scholia
- Cerqueira A, Martín A, Symonds CE, Odajima J, Dubus P, Barbacid M, Santamaría D.; ''Genetic characterization of the role of the Cip/Kip family of proteins as cyclin-dependent kinase inhibitors and assembly factors.''; PubMed Europe PMC Scholia
- Kuzmichev A, Nishioka K, Erdjument-Bromage H, Tempst P, Reinberg D.; ''Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein.''; PubMed Europe PMC Scholia
- Sherr CJ, Roberts JM.; ''CDK inhibitors: positive and negative regulators of G1-phase progression.''; PubMed Europe PMC Scholia
- Orjalo AV, Bhaumik D, Gengler BK, Scott GK, Campisi J.; ''Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network.''; PubMed Europe PMC Scholia
- Lees JA, Saito M, Vidal M, Valentine M, Look T, Harlow E, Dyson N, Helin K.; ''The retinoblastoma protein binds to a family of E2F transcription factors.''; PubMed Europe PMC Scholia
- Zou L, Stillman B.; ''Assembly of a complex containing Cdc45p, replication protein A, and Mcm2p at replication origins controlled by S-phase cyclin-dependent kinases and Cdc7p-Dbf4p kinase.''; PubMed Europe PMC Scholia
- Zhang Y, Xiong Y, Yarbrough WG.; ''ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways.''; PubMed Europe PMC Scholia
- Ikeda O, Miyasaka Y, Sekine Y, Mizushima A, Muromoto R, Nanbo A, Yoshimura A, Matsuda T.; ''STAP-2 is phosphorylated at tyrosine-250 by Brk and modulates Brk-mediated STAT3 activation.''; PubMed Europe PMC Scholia
- Hsu JY, Reimann JD, Sørensen CS, Lukas J, Jackson PK.; ''E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1).''; PubMed Europe PMC Scholia
- Wohlschlegel JA, Dwyer BT, Dhar SK, Cvetic C, Walter JC, Dutta A.; ''Inhibition of eukaryotic DNA replication by geminin binding to Cdt1.''; PubMed Europe PMC Scholia
- Dou QP, Zhao S, Levin AH, Wang J, Helin K, Pardee AB.; ''G1/S-regulated E2F-containing protein complexes bind to the mouse thymidine kinase gene promoter.''; PubMed Europe PMC Scholia
- Bockstaele L, Coulonval K, Kooken H, Paternot S, Roger PP.; ''Regulation of CDK4.''; PubMed Europe PMC Scholia
- Agherbi H, Gaussmann-Wenger A, Verthuy C, Chasson L, Serrano M, Djabali M.; ''Polycomb mediated epigenetic silencing and replication timing at the INK4a/ARF locus during senescence.''; PubMed Europe PMC Scholia
- Acosta JC, O'Loghlen A, Banito A, Guijarro MV, Augert A, Raguz S, Fumagalli M, Da Costa M, Brown C, Popov N, Takatsu Y, Melamed J, d'Adda di Fagagna F, Bernard D, Hernando E, Gil J.; ''Chemokine signaling via the CXCR2 receptor reinforces senescence.''; PubMed Europe PMC Scholia
- Chien Y, Scuoppo C, Wang X, Fang X, Balgley B, Bolden JE, Premsrirut P, Luo W, Chicas A, Lee CS, Kogan SC, Lowe SW.; ''Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity.''; PubMed Europe PMC Scholia
- Takahashi A, Imai Y, Yamakoshi K, Kuninaka S, Ohtani N, Yoshimoto S, Hori S, Tachibana M, Anderton E, Takeuchi T, Shinkai Y, Peters G, Saya H, Hara E.; ''DNA damage signaling triggers degradation of histone methyltransferases through APC/C(Cdh1) in senescent cells.''; PubMed Europe PMC Scholia
- Lindeman GJ, Gaubatz S, Livingston DM, Ginsberg D.; ''The subcellular localization of E2F-4 is cell-cycle dependent.''; PubMed Europe PMC Scholia
- Senturk S, Mumcuoglu M, Gursoy-Yuzugullu O, Cingoz B, Akcali KC, Ozturk M.; ''Transforming growth factor-beta induces senescence in hepatocellular carcinoma cells and inhibits tumor growth.''; PubMed Europe PMC Scholia
- Lukong KE, Huot ME, Richard S.; ''BRK phosphorylates PSF promoting its cytoplasmic localization and cell cycle arrest.''; PubMed Europe PMC Scholia
- Hansen K, Farkas T, Lukas J, Holm K, Rönnstrand L, Bartek J.; ''Phosphorylation-dependent and -independent functions of p130 cooperate to evoke a sustained G1 block.''; PubMed Europe PMC Scholia
- Jimi E, Ikebe T, Takahashi N, Hirata M, Suda T, Koga T.; ''Interleukin-1 alpha activates an NF-kappaB-like factor in osteoclast-like cells.''; PubMed Europe PMC Scholia
- Shen CH, Chen HY, Lin MS, Li FY, Chang CC, Kuo ML, Settleman J, Chen RH.; ''Breast tumor kinase phosphorylates p190RhoGAP to regulate rho and ras and promote breast carcinoma growth, migration, and invasion.''; PubMed Europe PMC Scholia
- Rayman JB, Takahashi Y, Indjeian VB, Dannenberg JH, Catchpole S, Watson RJ, te Riele H, Dynlacht BD.; ''E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex.''; PubMed Europe PMC Scholia
- Magenta A, Fasanaro P, Romani S, Di Stefano V, Capogrossi MC, Martelli F.; ''Protein phosphatase 2A subunit PR70 interacts with pRb and mediates its dephosphorylation.''; PubMed Europe PMC Scholia
- Bagchi S, Weinmann R, Raychaudhuri P.; ''The retinoblastoma protein copurifies with E2F-I, an E1A-regulated inhibitor of the transcription factor E2F.''; PubMed Europe PMC Scholia
- Chittenden T, Livingston DM, Kaelin WG.; ''The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein.''; PubMed Europe PMC Scholia
- Coulonval K, Bockstaele L, Paternot S, Dumont JE, Roger PP.; ''The cyclin D3-CDK4-p27kip1 holoenzyme in thyroid epithelial cells: activation by TSH, inhibition by TGFbeta, and phosphorylations of its subunits demonstrated by two-dimensional gel electrophoresis.''; PubMed Europe PMC Scholia
- Blain SW.; ''Switching cyclin D-Cdk4 kinase activity on and off.''; PubMed Europe PMC Scholia
- Chung M, Liu C, Yang HW, Köberlin MS, Cappell SD, Meyer T.; ''Transient Hysteresis in CDK4/6 Activity Underlies Passage of the Restriction Point in G1.''; PubMed Europe PMC Scholia
- Ostrander JH, Daniel AR, Lofgren K, Kleer CG, Lange CA.; ''Breast tumor kinase (protein tyrosine kinase 6) regulates heregulin-induced activation of ERK5 and p38 MAP kinases in breast cancer cells.''; PubMed Europe PMC Scholia
- Yang BS, Hauser CA, Henkel G, Colman MS, Van Beveren C, Stacey KJ, Hume DA, Maki RA, Ostrowski MC.; ''Ras-mediated phosphorylation of a conserved threonine residue enhances the transactivation activities of c-Ets1 and c-Ets2.''; PubMed Europe PMC Scholia
- Bagui TK, Mohapatra S, Haura E, Pledger WJ.; ''P27Kip1 and p21Cip1 are not required for the formation of active D cyclin-cdk4 complexes.''; PubMed Europe PMC Scholia
- Schachter MM, Merrick KA, Larochelle S, Hirschi A, Zhang C, Shokat KM, Rubin SM, Fisher RP.; ''A Cdk7-Cdk4 T-loop phosphorylation cascade promotes G1 progression.''; PubMed Europe PMC Scholia
- Zhu XH, Nguyen H, Halicka HD, Traganos F, Koff A.; ''Noncatalytic requirement for cyclin A-cdk2 in p27 turnover.''; PubMed Europe PMC Scholia
- Gambus A, van Deursen F, Polychronopoulos D, Foltman M, Jones RC, Edmondson RD, Calzada A, Labib K.; ''A key role for Ctf4 in coupling the MCM2-7 helicase to DNA polymerase alpha within the eukaryotic replisome.''; PubMed Europe PMC Scholia
- Yan Z, DeGregori J, Shohet R, Leone G, Stillman B, Nevins JR, Williams RS.; ''Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells.''; PubMed Europe PMC Scholia
- Rodier F, Coppé JP, Patil CK, Hoeijmakers WA, Muñoz DP, Raza SR, Freund A, Campeau E, Davalos AR, Campisi J.; ''Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion.''; PubMed Europe PMC Scholia
- Yoshida K, Inoue I.; ''Regulation of Geminin and Cdt1 expression by E2F transcription factors.''; PubMed Europe PMC Scholia
- Meng W, Swenson LL, Fitzgibbon MJ, Hayakawa K, Ter Haar E, Behrens AE, Fulghum JR, Lippke JA.; ''Structure of mitogen-activated protein kinase-activated protein (MAPKAP) kinase 2 suggests a bifunctional switch that couples kinase activation with nuclear export.''; PubMed Europe PMC Scholia
- Zhou BP, Liao Y, Xia W, Spohn B, Lee MH, Hung MC.; ''Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells.''; PubMed Europe PMC Scholia
- Ezhevsky SA, Ho A, Becker-Hapak M, Davis PK, Dowdy SF.; ''Differential regulation of retinoblastoma tumor suppressor protein by G(1) cyclin-dependent kinase complexes in vivo.''; PubMed Europe PMC Scholia
- Shin I, Rotty J, Wu FY, Arteaga CL.; ''Phosphorylation of p27Kip1 at Thr-157 interferes with its association with importin alpha during G1 and prevents nuclear re-entry.''; PubMed Europe PMC Scholia
- Viglietto G, Motti ML, Bruni P, Melillo RM, D'Alessio A, Califano D, Vinci F, Chiappetta G, Tsichlis P, Bellacosa A, Fusco A, Santoro M.; ''Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer.''; PubMed Europe PMC Scholia
- Raingeaud J, Whitmarsh AJ, Barrett T, Dérijard B, Davis RJ.; ''MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway.''; PubMed Europe PMC Scholia
- Darbinian N, Gallia GL, Kundu M, Shcherbik N, Tretiakova A, Giordano A, Khalili K.; ''Association of Pur alpha and E2F-1 suppresses transcriptional activity of E2F-1.''; PubMed Europe PMC Scholia
- Zhang P, Ostrander JH, Faivre EJ, Olsen A, Fitzsimmons D, Lange CA.; ''Regulated association of protein kinase B/Akt with breast tumor kinase.''; PubMed Europe PMC Scholia
- Kamalati T, Jolin HE, Fry MJ, Crompton MR.; ''Expression of the BRK tyrosine kinase in mammary epithelial cells enhances the coupling of EGF signalling to PI 3-kinase and Akt, via erbB3 phosphorylation.''; PubMed Europe PMC Scholia
- Blomberg I, Hoffmann I.; ''Ectopic expression of Cdc25A accelerates the G(1)/S transition and leads to premature activation of cyclin E- and cyclin A-dependent kinases.''; PubMed Europe PMC Scholia
- Jiang W, McDonald D, Hope TJ, Hunter T.; ''Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication.''; PubMed Europe PMC Scholia
- Woo MS, Sánchez I, Dynlacht BD.; ''p130 and p107 use a conserved domain to inhibit cellular cyclin-dependent kinase activity.''; PubMed Europe PMC Scholia
- Erickson S, Sangfelt O, Heyman M, Castro J, Einhorn S, Grandér D.; ''Involvement of the Ink4 proteins p16 and p15 in T-lymphocyte senescence.''; PubMed Europe PMC Scholia
- Pires IM, Blokland NJ, Broos AW, Poujade FA, Senra JM, Eccles SA, Span PN, Harvey AJ, Hammond EM.; ''HIF-1α-independent hypoxia-induced rapid PTK6 stabilization is associated with increased motility and invasion.''; PubMed Europe PMC Scholia
- Fleming Y, Armstrong CG, Morrice N, Paterson A, Goedert M, Cohen P.; ''Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7.''; PubMed Europe PMC Scholia
- LaBaer J, Garrett MD, Stevenson LF, Slingerland JM, Sandhu C, Chou HS, Fattaey A, Harlow E.; ''New functional activities for the p21 family of CDK inhibitors.''; PubMed Europe PMC Scholia
- Giangrande PH, Zhu W, Rempel RE, Laakso N, Nevins JR.; ''Combinatorial gene control involving E2F and E Box family members.''; PubMed Europe PMC Scholia
- Larrea MD, Liang J, Da Silva T, Hong F, Shao SH, Han K, Dumont D, Slingerland JM.; ''Phosphorylation of p27Kip1 regulates assembly and activation of cyclin D1-Cdk4.''; PubMed Europe PMC Scholia
- Meyerson M, Harlow E.; ''Identification of G1 kinase activity for cdk6, a novel cyclin D partner.''; PubMed Europe PMC Scholia
- Kang SA, Lee ST.; ''PTK6 promotes degradation of c-Cbl through PTK6-mediated phosphorylation.''; PubMed Europe PMC Scholia
- Serrano M, Hannon GJ, Beach D.; ''A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4.''; PubMed Europe PMC Scholia
- Sugimoto M, Martin N, Wilks DP, Tamai K, Huot TJ, Pantoja C, Okumura K, Serrano M, Hara E.; ''Activation of cyclin D1-kinase in murine fibroblasts lacking both p21(Cip1) and p27(Kip1).''; PubMed Europe PMC Scholia
- Wotton D, Lo RS, Lee S, Massagué J.; ''A Smad transcriptional corepressor.''; PubMed Europe PMC Scholia
- Asano M, Wharton RP.; ''E2F mediates developmental and cell cycle regulation of ORC1 in Drosophila.''; PubMed Europe PMC Scholia
- Parry D, Bates S, Mann DJ, Peters G.; ''Lack of cyclin D-Cdk complexes in Rb-negative cells correlates with high levels of p16INK4/MTS1 tumour suppressor gene product.''; PubMed Europe PMC Scholia
- Jackman M, Kubota Y, den Elzen N, Hagting A, Pines J.; ''Cyclin A- and cyclin E-Cdk complexes shuttle between the nucleus and the cytoplasm.''; PubMed Europe PMC Scholia
- Lin X, Duan X, Liang YY, Su Y, Wrighton KH, Long J, Hu M, Davis CM, Wang J, Brunicardi FC, Shi Y, Chen YG, Meng A, Feng XH.; ''PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling.''; PubMed Europe PMC Scholia
- Ohtani K, Nevins JR.; ''Functional properties of a Drosophila homolog of the E2F1 gene.''; PubMed Europe PMC Scholia
- To KH, Pajovic S, Gallie BL, Thériault BL.; ''Regulation of p14ARF expression by miR-24: a potential mechanism compromising the p53 response during retinoblastoma development.''; PubMed Europe PMC Scholia
- Ray A, James MK, Larochelle S, Fisher RP, Blain SW.; ''p27Kip1 inhibits cyclin D-cyclin-dependent kinase 4 by two independent modes.''; PubMed Europe PMC Scholia
- Lin TY, Cheng YC, Yang HC, Lin WC, Wang CC, Lai PL, Shieh SY.; ''Loss of the candidate tumor suppressor BTG3 triggers acute cellular senescence via the ERK-JMJD3-p16(INK4a) signaling axis.''; PubMed Europe PMC Scholia
- Sadasivam S, DeCaprio JA.; ''The DREAM complex: master coordinator of cell cycle-dependent gene expression.''; PubMed Europe PMC Scholia
- White A, Pargellis CA, Studts JM, Werneburg BG, Farmer BT.; ''Molecular basis of MAPK-activated protein kinase 2:p38 assembly.''; PubMed Europe PMC Scholia
- Depoortere F, Van Keymeulen A, Lukas J, Costagliola S, Bartkova J, Dumont JE, Bartek J, Roger PP, Dremier S.; ''A requirement for cyclin D3-cyclin-dependent kinase (cdk)-4 assembly in the cyclic adenosine monophosphate-dependent proliferation of thyrocytes.''; PubMed Europe PMC Scholia
- Litovchick L, Florens LA, Swanson SK, Washburn MP, DeCaprio JA.; ''DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly.''; PubMed Europe PMC Scholia
- Kang SA, Lee ES, Yoon HY, Randazzo PA, Lee ST.; ''PTK6 inhibits down-regulation of EGF receptor through phosphorylation of ARAP1.''; PubMed Europe PMC Scholia
- Varelas X, Sakuma R, Samavarchi-Tehrani P, Peerani R, Rao BM, Dembowy J, Yaffe MB, Zandstra PW, Wrana JL.; ''TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal.''; PubMed Europe PMC Scholia
- Saitoh M, Nishitoh H, Fujii M, Takeda K, Tobiume K, Sawada Y, Kawabata M, Miyazono K, Ichijo H.; ''Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1.''; PubMed Europe PMC Scholia
- Malumbres M, Pérez De Castro I, Hernández MI, Jiménez M, Corral T, Pellicer A.; ''Cellular response to oncogenic ras involves induction of the Cdk4 and Cdk6 inhibitor p15(INK4b).''; PubMed Europe PMC Scholia
- Li YY, Wang L, Lu CD.; ''An E2F site in the 5'-promoter region contributes to serum-dependent up-regulation of the human proliferating cell nuclear antigen gene.''; PubMed Europe PMC Scholia
- Matsusaka T, Fujikawa K, Nishio Y, Mukaida N, Matsushima K, Kishimoto T, Akira S.; ''Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8.''; PubMed Europe PMC Scholia
- Wei SJ, Williams JG, Dang H, Darden TA, Betz BL, Humble MM, Chang FM, Trempus CS, Johnson K, Cannon RE, Tennant RW.; ''Identification of a specific motif of the DSS1 protein required for proteasome interaction and p53 protein degradation.''; PubMed Europe PMC Scholia
- Stroschein SL, Wang W, Zhou S, Zhou Q, Luo K.; ''Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein.''; PubMed Europe PMC Scholia
- Narasimha AM, Kaulich M, Shapiro GS, Choi YJ, Sicinski P, Dowdy SF.; ''Cyclin D activates the Rb tumor suppressor by mono-phosphorylation.''; PubMed Europe PMC Scholia
- Hubscher U, Maga G, Spadari S.; ''Eukaryotic DNA polymerases.''; PubMed Europe PMC Scholia
- Paternot S, Roger PP.; ''Combined inhibition of MEK and mammalian target of rapamycin abolishes phosphorylation of cyclin-dependent kinase 4 in glioblastoma cell lines and prevents their proliferation.''; PubMed Europe PMC Scholia
- Duronio RJ, O'Farrell PH.; ''Developmental control of a G1-S transcriptional program in Drosophila.''; PubMed Europe PMC Scholia
- Lukas SM, Kroe RR, Wildeson J, Peet GW, Frego L, Davidson W, Ingraham RH, Pargellis CA, Labadia ME, Werneburg BG.; ''Catalysis and function of the p38 alpha.MK2a signaling complex.''; PubMed Europe PMC Scholia
- Weinmann AS, Bartley SM, Zhang T, Zhang MQ, Farnham PJ.; ''Use of chromatin immunoprecipitation to clone novel E2F target promoters.''; PubMed Europe PMC Scholia
- Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ.; ''The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.''; PubMed Europe PMC Scholia
- Kuilman T, Michaloglou C, Vredeveld LC, Douma S, van Doorn R, Desmet CJ, Aarden LA, Mooi WJ, Peeper DS.; ''Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network.''; PubMed Europe PMC Scholia
- Knudsen KE, Booth D, Naderi S, Sever-Chroneos Z, Fribourg AF, Hunton IC, Feramisco JR, Wang JY, Knudsen ES.; ''RB-dependent S-phase response to DNA damage.''; PubMed Europe PMC Scholia
- Wells JM, Illenye S, Magae J, Wu CL, Heintz NH.; ''Accumulation of E2F-4.DP-1 DNA binding complexes correlates with induction of dhfr gene expression during the G1 to S phase transition.''; PubMed Europe PMC Scholia
- Wu CL, Kirley SD, Xiao H, Chuang Y, Chung DC, Zukerberg LR.; ''Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1, inhibits cell growth, and is lost in many human colon and squamous cancers.''; PubMed Europe PMC Scholia
- Wang Z, Xie Y, Zhang L, Zhang H, An X, Wang T, Meng A.; ''Migratory localization of cyclin D2-Cdk4 complex suggests a spatial regulation of the G1-S transition.''; PubMed Europe PMC Scholia
- Brown VD, Phillips RA, Gallie BL.; ''Cumulative effect of phosphorylation of pRB on regulation of E2F activity.''; PubMed Europe PMC Scholia
- Kukimoto I, Igaki H, Kanda T.; ''Human CDC45 protein binds to minichromosome maintenance 7 protein and the p70 subunit of DNA polymerase alpha.''; PubMed Europe PMC Scholia
- Haegebarth A, Heap D, Bie W, Derry JJ, Richard S, Tyner AL.; ''The nuclear tyrosine kinase BRK/Sik phosphorylates and inhibits the RNA-binding activities of the Sam68-like mammalian proteins SLM-1 and SLM-2.''; PubMed Europe PMC Scholia
- Chakraborty G, Jain S, Kundu GC.; ''Osteopontin promotes vascular endothelial growth factor-dependent breast tumor growth and angiogenesis via autocrine and paracrine mechanisms.''; PubMed Europe PMC Scholia
- McLaughlin MM, Kumar S, McDonnell PC, Van Horn S, Lee JC, Livi GP, Young PR.; ''Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase.''; PubMed Europe PMC Scholia
- Bockstaele L, Kooken H, Libert F, Paternot S, Dumont JE, de Launoit Y, Roger PP, Coulonval K.; ''Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK "inhibitors".''; PubMed Europe PMC Scholia
- Bailly S, Fay M, Israël N, Gougerot-Pocidalo MA.; ''The transcription factor AP-1 binds to the human interleukin 1 alpha promoter.''; PubMed Europe PMC Scholia
- Fien K, Cho YS, Lee JK, Raychaudhuri S, Tappin I, Hurwitz J.; ''Primer utilization by DNA polymerase alpha-primase is influenced by its interaction with Mcm10p.''; PubMed Europe PMC Scholia
- Furukawa Y, Terui Y, Sakoe K, Ohta M, Saito M.; ''The role of cellular transcription factor E2F in the regulation of cdc2 mRNA expression and cell cycle control of human hematopoietic cells.''; PubMed Europe PMC Scholia
- Litovchick L, Sadasivam S, Florens L, Zhu X, Swanson SK, Velmurugan S, Chen R, Washburn MP, Liu XS, DeCaprio JA.; ''Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence.''; PubMed Europe PMC Scholia
- Zhang Y, Baranovskiy AG, Tahirov TH, Pavlov YI.; ''The C-terminal domain of the DNA polymerase catalytic subunit regulates the primase and polymerase activities of the human DNA polymerase α-primase complex.''; PubMed Europe PMC Scholia
- Adams PD, Li X, Sellers WR, Baker KB, Leng X, Harper JW, Taya Y, Kaelin WG.; ''Retinoblastoma protein contains a C-terminal motif that targets it for phosphorylation by cyclin-cdk complexes.''; PubMed Europe PMC Scholia
- Jäkel H, Weinl C, Hengst L.; ''Phosphorylation of p27Kip1 by JAK2 directly links cytokine receptor signaling to cell cycle control.''; PubMed Europe PMC Scholia
- Deacon K, Blank JL.; ''Characterization of the mitogen-activated protein kinase kinase 4 (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/p38 pathways regulated by MEK kinases 2 and 3. MEK kinase 3 activates MKK3 but does not cause activation of p38 kinase in vivo.''; PubMed Europe PMC Scholia
- Lukong KE, Richard S.; ''Breast tumor kinase BRK requires kinesin-2 subunit KAP3A in modulation of cell migration.''; PubMed Europe PMC Scholia
- Okazaki K, Sagata N.; ''The Mos/MAP kinase pathway stabilizes c-Fos by phosphorylation and augments its transforming activity in NIH 3T3 cells.''; PubMed Europe PMC Scholia
- Sharpless NE, Sherr CJ.; ''Forging a signature of in vivo senescence.''; PubMed Europe PMC Scholia
- New L, Jiang Y, Zhao M, Liu K, Zhu W, Flood LJ, Kato Y, Parry GC, Han J.; ''PRAK, a novel protein kinase regulated by the p38 MAP kinase.''; PubMed Europe PMC Scholia
- Paternot S, Bockstaele L, Bisteau X, Kooken H, Coulonval K, Roger PP.; ''Rb inactivation in cell cycle and cancer: the puzzle of highly regulated activating phosphorylation of CDK4 versus constitutively active CDK-activating kinase.''; PubMed Europe PMC Scholia
- James MK, Ray A, Leznova D, Blain SW.; ''Differential modification of p27Kip1 controls its cyclin D-cdk4 inhibitory activity.''; PubMed Europe PMC Scholia
- Zhu W, Giangrande PH, Nevins JR.; ''E2Fs link the control of G1/S and G2/M transcription.''; PubMed Europe PMC Scholia
- Dupont S, Mamidi A, Cordenonsi M, Montagner M, Zacchigna L, Adorno M, Martello G, Stinchfield MJ, Soligo S, Morsut L, Inui M, Moro S, Modena N, Argenton F, Newfeld SJ, Piccolo S.; ''FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination.''; PubMed Europe PMC Scholia
- Voges D, Zwickl P, Baumeister W.; ''The 26S proteasome: a molecular machine designed for controlled proteolysis.''; PubMed Europe PMC Scholia
- Lee S, Shuman JD, Guszczynski T, Sakchaisri K, Sebastian T, Copeland TD, Miller M, Cohen MS, Taunton J, Smart RC, Xiao Z, Yu LR, Veenstra TD, Johnson PF.; ''RSK-mediated phosphorylation in the C/EBP{beta} leucine zipper regulates DNA binding, dimerization, and growth arrest activity.''; PubMed Europe PMC Scholia
- Ainbinder E, Bergelson S, Pinkus R, Daniel V.; ''Regulatory mechanisms involved in activator-protein-1 (AP-1)-mediated activation of glutathione-S-transferase gene expression by chemical agents.''; PubMed Europe PMC Scholia
- Li X, Lu Y, Liang K, Hsu JM, Albarracin C, Mills GB, Hung MC, Fan Z.; ''Brk/PTK6 sustains activated EGFR signaling through inhibiting EGFR degradation and transactivating EGFR.''; PubMed Europe PMC Scholia
- Xiang B, Chatti K, Qiu H, Lakshmi B, Krasnitz A, Hicks J, Yu M, Miller WT, Muthuswamy SK.; ''Brk is coamplified with ErbB2 to promote proliferation in breast cancer.''; PubMed Europe PMC Scholia
- Kamalati T, Jolin HE, Mitchell PJ, Barker KT, Jackson LE, Dean CJ, Page MJ, Gusterson BA, Crompton MR.; ''Brk, a breast tumor-derived non-receptor protein-tyrosine kinase, sensitizes mammary epithelial cells to epidermal growth factor.''; PubMed Europe PMC Scholia
- Fuchs SY, Adler V, Buschmann T, Wu X, Ronai Z.; ''Mdm2 association with p53 targets its ubiquitination.''; PubMed Europe PMC Scholia
- Quelle DE, Zindy F, Ashmun RA, Sherr CJ.; ''Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest.''; PubMed Europe PMC Scholia
- Wajapeyee N, Serra RW, Zhu X, Mahalingam M, Green MR.; ''Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7.''; PubMed Europe PMC Scholia
- Mizukami Y, Yoshioka K, Morimoto S, Yoshida Ki.; ''A novel mechanism of JNK1 activation. Nuclear translocation and activation of JNK1 during ischemia and reperfusion.''; PubMed Europe PMC Scholia
- Foulds CE, Nelson ML, Blaszczak AG, Graves BJ.; ''Ras/mitogen-activated protein kinase signaling activates Ets-1 and Ets-2 by CBP/p300 recruitment.''; PubMed Europe PMC Scholia
- Saha P, Thome KC, Yamaguchi R, Hou Z, Weremowicz S, Dutta A.; ''The human homolog of Saccharomyces cerevisiae CDC45.''; PubMed Europe PMC Scholia
- Matsushime H, Ewen ME, Strom DK, Kato JY, Hanks SK, Roussel MF, Sherr CJ.; ''Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins.''; PubMed Europe PMC Scholia
- Peng M, Ball-Kell SM, Tyner AL.; ''Protein tyrosine kinase 6 promotes ERBB2-induced mammary gland tumorigenesis in the mouse.''; PubMed Europe PMC Scholia
- Ohtani K, Tsujimoto A, Ikeda M, Nakamura M.; ''Regulation of cell growth-dependent expression of mammalian CDC6 gene by the cell cycle transcription factor E2F.''; PubMed Europe PMC Scholia
- Nicke B, Bastien J, Khanna SJ, Warne PH, Cowling V, Cook SJ, Peters G, Delpuech O, Schulze A, Berns K, Mullenders J, Beijersbergen RL, Bernards R, Ganesan TS, Downward J, Hancock DC.; ''Involvement of MINK, a Ste20 family kinase, in Ras oncogene-induced growth arrest in human ovarian surface epithelial cells.''; PubMed Europe PMC Scholia
- Hukkelhoven E, Liu Y, Yeh N, Ciznadija D, Blain SW, Koff A.; ''Tyrosine phosphorylation of the p21 cyclin-dependent kinase inhibitor facilitates the development of proneural glioma.''; PubMed Europe PMC Scholia
- Zhang H.; ''Life without kinase: cyclin E promotes DNA replication licensing and beyond.''; PubMed Europe PMC Scholia
- Wu X, Bayle JH, Olson D, Levine AJ.; ''The p53-mdm-2 autoregulatory feedback loop.''; PubMed Europe PMC Scholia
- Liu N, Lucibello FC, Engeland K, Müller R.; ''A new model of cell cycle-regulated transcription: repression of the cyclin A promoter by CDF-1 and anti-repression by E2F.''; PubMed Europe PMC Scholia
- Jayadeva G, Kurimchak A, Garriga J, Sotillo E, Davis AJ, Haines DS, Mumby M, Graña X.; ''B55alpha PP2A holoenzymes modulate the phosphorylation status of the retinoblastoma-related protein p107 and its activation.''; PubMed Europe PMC Scholia
- Kato JY, Matsuoka M, Strom DK, Sherr CJ.; ''Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase.''; PubMed Europe PMC Scholia
- Acosta JC, Banito A, Wuestefeld T, Georgilis A, Janich P, Morton JP, Athineos D, Kang TW, Lasitschka F, Andrulis M, Pascual G, Morris KJ, Khan S, Jin H, Dharmalingam G, Snijders AP, Carroll T, Capper D, Pritchard C, Inman GJ, Longerich T, Sansom OJ, Benitah SA, Zender L, Gil J.; ''A complex secretory program orchestrated by the inflammasome controls paracrine senescence.''; PubMed Europe PMC Scholia
- Regan Anderson TM, Peacock DL, Daniel AR, Hubbard GK, Lofgren KA, Girard BJ, Schörg A, Hoogewijs D, Wenger RH, Seagroves TN, Lange CA.; ''Breast tumor kinase (Brk/PTK6) is a mediator of hypoxia-associated breast cancer progression.''; PubMed Europe PMC Scholia
- Ohtani K, DeGregori J, Nevins JR.; ''Regulation of the cyclin E gene by transcription factor E2F1.''; PubMed Europe PMC Scholia
- Sanidas I, Morris R, Fella KA, Rumde PH, Boukhali M, Tai EC, Ting DT, Lawrence MS, Haas W, Dyson NJ.; ''A Code of Mono-phosphorylation Modulates the Function of RB.''; PubMed Europe PMC Scholia
- Bell SP, Dutta A.; ''DNA replication in eukaryotic cells.''; PubMed Europe PMC Scholia
- Seidel JJ, Graves BJ.; ''An ERK2 docking site in the Pointed domain distinguishes a subset of ETS transcription factors.''; PubMed Europe PMC Scholia
- Hannon GJ, Beach D.; ''p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest.''; PubMed Europe PMC Scholia
- Avni D, Yang H, Martelli F, Hofmann F, ElShamy WM, Ganesan S, Scully R, Livingston DM.; ''Active localization of the retinoblastoma protein in chromatin and its response to S phase DNA damage.''; PubMed Europe PMC Scholia
- Nakajima T, Kinoshita S, Sasagawa T, Sasaki K, Naruto M, Kishimoto T, Akira S.; ''Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6.''; PubMed Europe PMC Scholia
- Arata Y, Fujita M, Ohtani K, Kijima S, Kato JY.; ''Cdk2-dependent and -independent pathways in E2F-mediated S phase induction.''; PubMed Europe PMC Scholia
- Dhar SK, Delmolino L, Dutta A.; ''Architecture of the human origin recognition complex.''; PubMed Europe PMC Scholia
- Kumagai H, Sato N, Yamada M, Mahony D, Seghezzi W, Lees E, Arai K, Masai H.; ''A novel growth- and cell cycle-regulated protein, ASK, activates human Cdc7-related kinase and is essential for G1/S transition in mammalian cells.''; PubMed Europe PMC Scholia
- Masai H, Matsui E, You Z, Ishimi Y, Tamai K, Arai K.; ''Human Cdc7-related kinase complex. In vitro phosphorylation of MCM by concerted actions of Cdks and Cdc7 and that of a criticial threonine residue of Cdc7 bY Cdks.''; PubMed Europe PMC Scholia
- Tsvetkov LM, Yeh KH, Lee SJ, Sun H, Zhang H.; ''p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27.''; PubMed Europe PMC Scholia
- Fang S, Jensen JP, Ludwig RL, Vousden KH, Weissman AM.; ''Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53.''; PubMed Europe PMC Scholia
- Fan G, Aleem S, Yang M, Miller WT, Tonks NK.; ''Protein-tyrosine Phosphatase and Kinase Specificity in Regulation of SRC and Breast Tumor Kinase.''; PubMed Europe PMC Scholia
- Vashee S, Simancek P, Challberg MD, Kelly TJ.; ''Assembly of the human origin recognition complex.''; PubMed Europe PMC Scholia
- Nelson ML, Kang HS, Lee GM, Blaszczak AG, Lau DK, McIntosh LP, Graves BJ.; ''Ras signaling requires dynamic properties of Ets1 for phosphorylation-enhanced binding to coactivator CBP.''; PubMed Europe PMC Scholia
- Desai D, Wessling HC, Fisher RP, Morgan DO.; ''Effects of phosphorylation by CAK on cyclin binding by CDC2 and CDK2.''; PubMed Europe PMC Scholia
- Matsuura H, Nishitoh H, Takeda K, Matsuzawa A, Amagasa T, Ito M, Yoshioka K, Ichijo H.; ''Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade.''; PubMed Europe PMC Scholia
- Guan KL, Jenkins CW, Li Y, Nichols MA, Wu X, O'Keefe CL, Matera AG, Xiong Y.; ''Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function.''; PubMed Europe PMC Scholia
- Connell-Crowley L, Harper JW, Goodrich DW.; ''Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation.''; PubMed Europe PMC Scholia
- Li Y, Asahara H, Patel VS, Zhou S, Linn S.; ''Purification, cDNA cloning, and gene mapping of the small subunit of human DNA polymerase epsilon.''; PubMed Europe PMC Scholia
- Wang W, Nacusi L, Sheaff RJ, Liu X.; ''Ubiquitination of p21Cip1/WAF1 by SCFSkp2: substrate requirement and ubiquitination site selection.''; PubMed Europe PMC Scholia
- Harbour JW, Luo RX, Dei Santi A, Postigo AA, Dean DC.; ''Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1.''; PubMed Europe PMC Scholia
- Liu S, Bolger JK, Kirkland LO, Premnath PN, McInnes C.; ''Structural and functional analysis of cyclin D1 reveals p27 and substrate inhibitor binding requirements.''; PubMed Europe PMC Scholia
- Parisi T, Pollice A, Di Cristofano A, Calabrò V, La Mantia G.; ''Transcriptional regulation of the human tumor suppressor p14(ARF) by E2F1, E2F2, E2F3, and Sp1-like factors.''; PubMed Europe PMC Scholia
- Hartupee J, Li X, Hamilton T.; ''Interleukin 1alpha-induced NFkappaB activation and chemokine mRNA stabilization diverge at IRAK1.''; PubMed Europe PMC Scholia
- Atwood AA, Sealy LJ.; ''C/EBPβ's role in determining Ras-induced senescence or transformation.''; PubMed Europe PMC Scholia
- Patel P, Asbach B, Shteyn E, Gomez C, Coltoff A, Bhuyan S, Tyner AL, Wagner R, Blain SW.; ''Brk/Protein tyrosine kinase 6 phosphorylates p27KIP1, regulating the activity of cyclin D-cyclin-dependent kinase 4.''; PubMed Europe PMC Scholia
- Coppé JP, Patil CK, Rodier F, Sun Y, Muñoz DP, Goldstein J, Nelson PS, Desprez PY, Campisi J.; ''Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor.''; PubMed Europe PMC Scholia
- Ishida N, Kitagawa M, Hatakeyama S, Nakayama K.; ''Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability.''; PubMed Europe PMC Scholia
- Kato JY, Matsuoka M, Polyak K, Massagué J, Sherr CJ.; ''Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation.''; PubMed Europe PMC Scholia
- Carrano AC, Eytan E, Hershko A, Pagano M.; ''SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27.''; PubMed Europe PMC Scholia
- Grimmler M, Wang Y, Mund T, Cilensek Z, Keidel EM, Waddell MB, Jäkel H, Kullmann M, Kriwacki RW, Hengst L.; ''Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases.''; PubMed Europe PMC Scholia
- Beijersbergen RL, Carlée L, Kerkhoven RM, Bernards R.; ''Regulation of the retinoblastoma protein-related p107 by G1 cyclin complexes.''; PubMed Europe PMC Scholia
- Izumi M, Yanagi K, Mizuno T, Yokoi M, Kawasaki Y, Moon KY, Hurwitz J, Yatagai F, Hanaoka F.; ''The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase.''; PubMed Europe PMC Scholia
- Voncken JW, Niessen H, Neufeld B, Rennefahrt U, Dahlmans V, Kubben N, Holzer B, Ludwig S, Rapp UR.; ''MAPKAP kinase 3pK phosphorylates and regulates chromatin association of the polycomb group protein Bmi1.''; PubMed Europe PMC Scholia
- Sithanandam G, Latif F, Duh FM, Bernal R, Smola U, Li H, Kuzmin I, Wixler V, Geil L, Shrestha S.; ''3pK, a new mitogen-activated protein kinase-activated protein kinase located in the small cell lung cancer tumor suppressor gene region.''; PubMed Europe PMC Scholia
- Bracken AP, Kleine-Kohlbrecher D, Dietrich N, Pasini D, Gargiulo G, Beekman C, Theilgaard-Mönch K, Minucci S, Porse BT, Marine JC, Hansen KH, Helin K.; ''The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells.''; PubMed Europe PMC Scholia
- Young AR, Narita M.; ''SASP reflects senescence.''; PubMed Europe PMC Scholia
- Bockstaele L, Bisteau X, Paternot S, Roger PP.; ''Differential regulation of cyclin-dependent kinase 4 (CDK4) and CDK6, evidence that CDK4 might not be activated by CDK7, and design of a CDK6 activating mutation.''; PubMed Europe PMC Scholia
- Moiseeva O, Bourdeau V, Roux A, Deschênes-Simard X, Ferbeyre G.; ''Mitochondrial dysfunction contributes to oncogene-induced senescence.''; PubMed Europe PMC Scholia
- Le Gallic L, Virgilio L, Cohen P, Biteau B, Mavrothalassitis G.; ''ERF nuclear shuttling, a continuous monitor of Erk activity that links it to cell cycle progression.''; PubMed Europe PMC Scholia
- Chattopadhyay S, Bielinsky AK.; ''Human Mcm10 regulates the catalytic subunit of DNA polymerase-alpha and prevents DNA damage during replication.''; PubMed Europe PMC Scholia
- Gao Z, Zhang J, Bonasio R, Strino F, Sawai A, Parisi F, Kluger Y, Reinberg D.; ''PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes.''; PubMed Europe PMC Scholia
- Ou L, Ferreira AM, Otieno S, Xiao L, Bashford D, Kriwacki RW.; ''Incomplete folding upon binding mediates Cdk4/cyclin D complex activation by tyrosine phosphorylation of inhibitor p27 protein.''; PubMed Europe PMC Scholia
- Tanizaki J, Okamoto I, Sakai K, Nakagawa K.; ''Differential roles of trans-phosphorylated EGFR, HER2, HER3, and RET as heterodimerisation partners of MET in lung cancer with MET amplification.''; PubMed Europe PMC Scholia
- Chellappan SP, Hiebert S, Mudryj M, Horowitz JM, Nevins JR.; ''The E2F transcription factor is a cellular target for the RB protein.''; PubMed Europe PMC Scholia
- Kelly BL, Wolfe KG, Roberts JM.; ''Identification of a substrate-targeting domain in cyclin E necessary for phosphorylation of the retinoblastoma protein.''; PubMed Europe PMC Scholia
- Niehof M, Streetz K, Rakemann T, Bischoff SC, Manns MP, Horn F, Trautwein C.; ''Interleukin-6-induced tethering of STAT3 to the LAP/C/EBPbeta promoter suggests a new mechanism of transcriptional regulation by STAT3.''; PubMed Europe PMC Scholia
- Lukong KE, Larocque D, Tyner AL, Richard S.; ''Tyrosine phosphorylation of sam68 by breast tumor kinase regulates intranuclear localization and cell cycle progression.''; PubMed Europe PMC Scholia
- Cheng M, Sexl V, Sherr CJ, Roussel MF.; ''Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1).''; PubMed Europe PMC Scholia
- Atwood AA, Sealy L.; ''Regulation of C/EBPbeta1 by Ras in mammary epithelial cells and the role of C/EBPbeta1 in oncogene-induced senescence.''; PubMed Europe PMC Scholia
- Jiang W, Wells NJ, Hunter T.; ''Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6.''; PubMed Europe PMC Scholia
- Leng X, Noble M, Adams PD, Qin J, Harper JW.; ''Reversal of growth suppression by p107 via direct phosphorylation by cyclin D1/cyclin-dependent kinase 4.''; PubMed Europe PMC Scholia
- Zheng Y, Asara JM, Tyner AL.; ''Protein-tyrosine kinase 6 promotes peripheral adhesion complex formation and cell migration by phosphorylating p130 CRK-associated substrate.''; PubMed Europe PMC Scholia
- Orend G, Hunter T, Ruoslahti E.; ''Cytoplasmic displacement of cyclin E-cdk2 inhibitors p21Cip1 and p27Kip1 in anchorage-independent cells.''; PubMed Europe PMC Scholia
- Bagui TK, Jackson RJ, Agrawal D, Pledger WJ.; ''Analysis of cyclin D3-cdk4 complexes in fibroblasts expressing and lacking p27(kip1) and p21(cip1).''; PubMed Europe PMC Scholia
- Tedesco D, Lukas J, Reed SI.; ''The pRb-related protein p130 is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(Skp2).''; PubMed Europe PMC Scholia
- Yu B, Lane ME, Pestell RG, Albanese C, Wadler S.; ''Downregulation of cyclin D1 alters cdk 4- and cdk 2-specific phosphorylation of retinoblastoma protein.''; PubMed Europe PMC Scholia
- Agger K, Cloos PA, Rudkjaer L, Williams K, Andersen G, Christensen J, Helin K.; ''The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence.''; PubMed Europe PMC Scholia
- Ono H, Basson MD, Ito H.; ''PTK6 promotes cancer migration and invasion in pancreatic cancer cells dependent on ERK signaling.''; PubMed Europe PMC Scholia
- Reynisdóttir I, Massagué J.; ''The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2.''; PubMed Europe PMC Scholia
- Dietrich N, Bracken AP, Trinh E, Schjerling CK, Koseki H, Rappsilber J, Helin K, Hansen KH.; ''Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus.''; PubMed Europe PMC Scholia
- Castro NE, Lange CA.; ''Breast tumor kinase and extracellular signal-regulated kinase 5 mediate Met receptor signaling to cell migration in breast cancer cells.''; PubMed Europe PMC Scholia
- Lundberg AS, Weinberg RA.; ''Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes.''; PubMed Europe PMC Scholia
- Bertoli C, Klier S, McGowan C, Wittenberg C, de Bruin RA.; ''Chk1 inhibits E2F6 repressor function in response to replication stress to maintain cell-cycle transcription.''; PubMed Europe PMC Scholia
- Bracken AP, Pasini D, Capra M, Prosperini E, Colli E, Helin K.; ''EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer.''; PubMed Europe PMC Scholia
- Galaktionov K, Chen X, Beach D.; ''Cdc25 cell-cycle phosphatase as a target of c-myc.''; PubMed Europe PMC Scholia
- DeGregori J, Kowalik T, Nevins JR.; ''Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes.''; PubMed Europe PMC Scholia
- Ohtani K, DeGregori J, Leone G, Herendeen DR, Kelly TJ, Nevins JR.; ''Expression of the HsOrc1 gene, a human ORC1 homolog, is regulated by cell proliferation via the E2F transcription factor.''; PubMed Europe PMC Scholia
- Vigo E, Müller H, Prosperini E, Hateboer G, Cartwright P, Moroni MC, Helin K.; ''CDC25A phosphatase is a target of E2F and is required for efficient E2F-induced S phase.''; PubMed Europe PMC Scholia
- Chu I, Sun J, Arnaout A, Kahn H, Hanna W, Narod S, Sun P, Tan CK, Hengst L, Slingerland J.; ''p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2.''; PubMed Europe PMC Scholia
- Hiebert SW.; ''Regions of the retinoblastoma gene product required for its interaction with the E2F transcription factor are necessary for E2 promoter repression and pRb-mediated growth suppression.''; PubMed Europe PMC Scholia
- Goel RK, Lukong KE.; ''Tracing the footprints of the breast cancer oncogene BRK - Past till present.''; PubMed Europe PMC Scholia
- Ohtani N, Zebedee Z, Huot TJ, Stinson JA, Sugimoto M, Ohashi Y, Sharrocks AD, Peters G, Hara E.; ''Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence.''; PubMed Europe PMC Scholia
- Remus D, Beuron F, Tolun G, Griffith JD, Morris EP, Diffley JF.; ''Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing.''; PubMed Europe PMC Scholia
- Ikeda O, Mizushima A, Sekine Y, Yamamoto C, Muromoto R, Nanbo A, Oritani K, Yoshimura A, Matsuda T.; ''Involvement of STAP-2 in Brk-mediated phosphorylation and activation of STAT5 in breast cancer cells.''; PubMed Europe PMC Scholia
- Ikeda O, Sekine Y, Mizushima A, Nakasuji M, Miyasaka Y, Yamamoto C, Muromoto R, Nanbo A, Oritani K, Yoshimura A, Matsuda T.; ''Interactions of STAP-2 with Brk and STAT3 participate in cell growth of human breast cancer cells.''; PubMed Europe PMC Scholia
- Zheng Y, Peng M, Wang Z, Asara JM, Tyner AL.; ''Protein tyrosine kinase 6 directly phosphorylates AKT and promotes AKT activation in response to epidermal growth factor.''; PubMed Europe PMC Scholia
- Chen HY, Shen CH, Tsai YT, Lin FC, Huang YP, Chen RH.; ''Brk activates rac1 and promotes cell migration and invasion by phosphorylating paxillin.''; PubMed Europe PMC Scholia
- Ganoth D, Bornstein G, Ko TK, Larsen B, Tyers M, Pagano M, Hershko A.; ''The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27.''; PubMed Europe PMC Scholia
- Vidal A, Koff A.; ''Cell-cycle inhibitors: three families united by a common cause.''; PubMed Europe PMC Scholia
- Walter J, Newport J.; ''Initiation of eukaryotic DNA replication: origin unwinding and sequential chromatin association of Cdc45, RPA, and DNA polymerase alpha.''; PubMed Europe PMC Scholia
- Li Y, Pursell ZF, Linn S.; ''Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon.''; PubMed Europe PMC Scholia
- Clifton AD, Young PR, Cohen P.; ''A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress.''; PubMed Europe PMC Scholia
- Ben-Levy R, Leighton IA, Doza YN, Attwood P, Morrice N, Marshall CJ, Cohen P.; ''Identification of novel phosphorylation sites required for activation of MAPKAP kinase-2.''; PubMed Europe PMC Scholia
- Montagnoli A, Fiore F, Eytan E, Carrano AC, Draetta GF, Hershko A, Pagano M.; ''Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation.''; PubMed Europe PMC Scholia
- Wu L, Timmers C, Maiti B, Saavedra HI, Sang L, Chong GT, Nuckolls F, Giangrande P, Wright FA, Field SJ, Greenberg ME, Orkin S, Nevins JR, Robinson ML, Leone G.; ''The E2F1-3 transcription factors are essential for cellular proliferation.''; PubMed Europe PMC Scholia
- Vijayachandra K, Lee J, Glick AB.; ''Smad3 regulates senescence and malignant conversion in a mouse multistage skin carcinogenesis model.''; PubMed Europe PMC Scholia
- Gao Y, Cimica V, Reich NC.; ''Suppressor of cytokine signaling 3 inhibits breast tumor kinase activation of STAT3.''; PubMed Europe PMC Scholia
- Takekawa M, Tatebayashi K, Saito H.; ''Conserved docking site is essential for activation of mammalian MAP kinase kinases by specific MAP kinase kinase kinases.''; PubMed Europe PMC Scholia
- Moiseeva O, Mallette FA, Mukhopadhyay UK, Moores A, Ferbeyre G.; ''DNA damage signaling and p53-dependent senescence after prolonged beta-interferon stimulation.''; PubMed Europe PMC Scholia
- Kotake Y, Cao R, Viatour P, Sage J, Zhang Y, Xiong Y.; ''pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4alpha tumor suppressor gene.''; PubMed Europe PMC Scholia
- Lal A, Kim HH, Abdelmohsen K, Kuwano Y, Pullmann R, Srikantan S, Subrahmanyam R, Martindale JL, Yang X, Ahmed F, Navarro F, Dykxhoorn D, Lieberman J, Gorospe M.; ''p16(INK4a) translation suppressed by miR-24.''; PubMed Europe PMC Scholia
- Kardinal C, Dangers M, Kardinal A, Koch A, Brandt DT, Tamura T, Welte K.; ''Tyrosine phosphorylation modulates binding preference to cyclin-dependent kinases and subcellular localization of p27Kip1 in the acute promyelocytic leukemia cell line NB4.''; PubMed Europe PMC Scholia
- Cobrinik D.; ''Pocket proteins and cell cycle control.''; PubMed Europe PMC Scholia
- Fan G, Lin G, Lucito R, Tonks NK.; ''Protein-tyrosine phosphatase 1B antagonized signaling by insulin-like growth factor-1 receptor and kinase BRK/PTK6 in ovarian cancer cells.''; PubMed Europe PMC Scholia
- Aprelikova O, Xiong Y, Liu ET.; ''Both p16 and p21 families of cyclin-dependent kinase (CDK) inhibitors block the phosphorylation of cyclin-dependent kinases by the CDK-activating kinase.''; PubMed Europe PMC Scholia
- Sgouras DN, Athanasiou MA, Beal GJ, Fisher RJ, Blair DG, Mavrothalassitis GJ.; ''ERF: an ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation.''; PubMed Europe PMC Scholia
History
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External references
DataNodes
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Annotated Interactions
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Source | Target | Type | Database reference | Comment |
---|---|---|---|---|
26S proteasome | mim-catalysis | R-HSA-187574 (Reactome) | ||
ADP | Arrow | R-HSA-1226094 (Reactome) | ||
ADP | Arrow | R-HSA-1226095 (Reactome) | ||
ADP | Arrow | R-HSA-1362270 (Reactome) | ||
ADP | Arrow | R-HSA-187520 (Reactome) | ||
ADP | Arrow | R-HSA-188350 (Reactome) | ||
ADP | Arrow | R-HSA-188390 (Reactome) | ||
ADP | Arrow | R-HSA-68954 (Reactome) | ||
ADP | Arrow | R-HSA-69195 (Reactome) | ||
ADP | Arrow | R-HSA-69213 (Reactome) | ||
ADP | Arrow | R-HSA-69223 (Reactome) | ||
ADP | Arrow | R-HSA-69227 (Reactome) | ||
ADP | Arrow | R-HSA-69690 (Reactome) | ||
ADP | Arrow | R-HSA-69691 (Reactome) | ||
ATP | R-HSA-1226094 (Reactome) | |||
ATP | R-HSA-1226095 (Reactome) | |||
ATP | R-HSA-1362270 (Reactome) | |||
ATP | R-HSA-187520 (Reactome) | |||
ATP | R-HSA-188350 (Reactome) | |||
ATP | R-HSA-188390 (Reactome) | |||
ATP | R-HSA-68954 (Reactome) | |||
ATP | R-HSA-69195 (Reactome) | |||
ATP | R-HSA-69213 (Reactome) | |||
ATP | R-HSA-69223 (Reactome) | |||
ATP | R-HSA-69227 (Reactome) | |||
ATP | R-HSA-69690 (Reactome) | |||
ATP | R-HSA-69691 (Reactome) | |||
Aborted replication complex | Arrow | R-HSA-113643 (Reactome) | ||
CAK | mim-catalysis | R-HSA-188350 (Reactome) | ||
CAK | mim-catalysis | R-HSA-69223 (Reactome) | ||
CCNA | Arrow | R-HSA-1362300 (Reactome) | ||
CDC25A | Arrow | R-HSA-113505 (Reactome) | ||
CDC25A | Arrow | R-HSA-1362277 (Reactome) | ||
CDC25A | Arrow | R-HSA-188345 (Reactome) | ||
CDC25A | mim-catalysis | R-HSA-69199 (Reactome) | ||
CDC45 | R-HSA-68917 (Reactome) | |||
CDC6 | Arrow | R-HSA-1362277 (Reactome) | ||
CDK1 | Arrow | R-HSA-1362300 (Reactome) | ||
CDK2 | R-HSA-69191 (Reactome) | |||
CDK:DDK:Mcm10:pre-replicative complex | Arrow | R-HSA-68918 (Reactome) | ||
CDK:DDK:Mcm10:pre-replicative complex | R-HSA-68917 (Reactome) | |||
CDKN1A | Arrow | R-HSA-187828 (Reactome) | ||
CDKN1A | R-HSA-187828 (Reactome) | |||
CDKN1B | Arrow | R-HSA-187506 (Reactome) | ||
CDKN1B | R-HSA-187506 (Reactome) | |||
CDK | R-HSA-68918 (Reactome) | |||
CDT1 | Arrow | R-HSA-68940 (Reactome) | ||
CKS1B | R-HSA-187545 (Reactome) | |||
Cdc45:CDK:DDK:Mcm10:pre-replicative complex | Arrow | R-HSA-68917 (Reactome) | ||
Cdc45:CDK:DDK:Mcm10:pre-replicative complex | R-HSA-68916 (Reactome) | |||
Cdk4/6:INK4A complex | Arrow | R-HSA-182594 (Reactome) | ||
Cdk4/6:INK4A complex | TBar | R-HSA-69213 (Reactome) | ||
Cdk4/6 | R-HSA-182594 (Reactome) | |||
Cdk4/6 | R-HSA-69213 (Reactome) | |||
Cyclin
D:CDK4/6:p21/p27 complex | Arrow | R-HSA-69213 (Reactome) | ||
Cyclin
D:CDK4/6:p21/p27 complex | R-HSA-141299 (Reactome) | |||
Cyclin D:Cdk4/6:p21/p27 | Arrow | R-HSA-141299 (Reactome) | ||
Cyclin D:Cdk4/6:p21/p27 | R-HSA-69223 (Reactome) | |||
Cyclin D:phospho-CDK4/6:p21/p27 | Arrow | R-HSA-69223 (Reactome) | ||
Cyclin D:phospho-CDK4/6:p21/p27 | mim-catalysis | R-HSA-1226094 (Reactome) | ||
Cyclin D:phospho-CDK4/6:p21/p27 | mim-catalysis | R-HSA-1226095 (Reactome) | ||
Cyclin D:phospho-CDK4/6:p21/p27 | mim-catalysis | R-HSA-69227 (Reactome) | ||
Cyclin E/A:Cdk2:multiubiquitinated phospho-p27/p21:SCF(Skp2):Cks1 complex | Arrow | R-HSA-187575 (Reactome) | ||
Cyclin E/A:Cdk2:multiubiquitinated phospho-p27/p21:SCF(Skp2):Cks1 complex | R-HSA-187574 (Reactome) | |||
Cyclin E/A:Cdk2:multiubiquitinated phospho-p27/p21:SCF(Skp2):Cks1 complex | mim-catalysis | R-HSA-187575 (Reactome) | ||
Cyclin
E/A:Cdk2:p27/p21 complex | R-HSA-187520 (Reactome) | |||
Cyclin
E/A:Cdk2:p27/p21 complex | mim-catalysis | R-HSA-187520 (Reactome) | ||
Cyclin E/A:Cdk2:phospho-p27/p21:SCF(Skp2):Cks1 complex | Arrow | R-HSA-187552 (Reactome) | ||
Cyclin E/A:Cdk2:phospho-p27/p21:SCF(Skp2):Cks1 complex | R-HSA-187575 (Reactome) | |||
Cyclin E/A:Cdk2:phospho-p27/p21 | Arrow | R-HSA-187520 (Reactome) | ||
Cyclin E/A:Cdk2:phospho-p27/p21 | R-HSA-187552 (Reactome) | |||
Cyclin
E1:phospho-Cdk2 complex | Arrow | R-HSA-69690 (Reactome) | ||
Cyclin
E2:phospho-Cdk2 complex | Arrow | R-HSA-69691 (Reactome) | ||
Cyclin
E:Cdk2:p21/p27 complex | Arrow | R-HSA-69562 (Reactome) | ||
Cyclin E:Phospho-Cdk2(Thr160):Rb complex | Arrow | R-HSA-188386 (Reactome) | ||
Cyclin E:Phospho-Cdk2(Thr160):Rb complex | R-HSA-188390 (Reactome) | |||
Cyclin E:Phospho-Cdk2(Thr160):Rb complex | mim-catalysis | R-HSA-188390 (Reactome) | ||
Cyclin
E:phospho-Cdk2 Complex | Arrow | R-HSA-69195 (Reactome) | ||
Cyclin
E:phospho-Cdk2 Complex | R-HSA-69199 (Reactome) | |||
Cyclin
E:phospho-Cdk2 (Thr 160):phospho-Rb | Arrow | R-HSA-188390 (Reactome) | ||
Cyclin B:Cdk1 complex | Arrow | R-HSA-113505 (Reactome) | ||
Cyclin B:Cdk1 complex | R-HSA-113638 (Reactome) | |||
Cyclin D | R-HSA-69213 (Reactome) | |||
Cyclin E/A:Cdk2 | Arrow | R-HSA-187574 (Reactome) | ||
Cyclin E/A:Cdk2 | R-HSA-1363303 (Reactome) | |||
Cyclin E/A:Cdk2 | R-HSA-1363306 (Reactome) | |||
Cyclin E/A:Cdk2 | R-HSA-1363311 (Reactome) | |||
Cyclin E/A:Cdk2 | R-HSA-1363314 (Reactome) | |||
Cyclin E1:Cdk2 complex | R-HSA-69690 (Reactome) | |||
Cyclin E2:Cdk2 complex | R-HSA-69691 (Reactome) | |||
Cyclin E:Cdk2 complex | Arrow | R-HSA-69191 (Reactome) | ||
Cyclin E:Cdk2 complex | R-HSA-157906 (Reactome) | |||
Cyclin E:Cdk2 complexes | Arrow | R-HSA-157906 (Reactome) | ||
Cyclin E:Cdk2 complexes | Arrow | R-HSA-69199 (Reactome) | ||
Cyclin E:Cdk2 complexes | R-HSA-188350 (Reactome) | |||
Cyclin E:Cdk2 complexes | R-HSA-69195 (Reactome) | |||
Cyclin E:Cdk2 complexes | R-HSA-69562 (Reactome) | |||
Cyclin E:Phosho-Cdk2 (Thr 160) | Arrow | R-HSA-188350 (Reactome) | ||
Cyclin E:Phosho-Cdk2 (Thr 160) | R-HSA-188386 (Reactome) | |||
Cyclin E | R-HSA-69191 (Reactome) | |||
DDK | R-HSA-68918 (Reactome) | |||
DDK | mim-catalysis | R-HSA-68954 (Reactome) | ||
DNA Replication Factor A | R-HSA-68916 (Reactome) | |||
DNA polymerase
alpha:primase:DNA polymerase alpha:origin complex | Arrow | R-HSA-68914 (Reactome) | ||
DNA polymerase alpha:primase | Arrow | R-HSA-113504 (Reactome) | ||
DNA polymerase alpha:primase | R-HSA-68914 (Reactome) | |||
DNA polymerase
epsilon:origin complex | Arrow | R-HSA-68960 (Reactome) | ||
DNA polymerase
epsilon:origin complex | R-HSA-68914 (Reactome) | |||
DNA polymerase epsilon | R-HSA-68960 (Reactome) | |||
DP-1:E2F1/2/3 | Arrow | R-HSA-69227 (Reactome) | ||
DREAM complex | Arrow | R-HSA-1362261 (Reactome) | ||
DREAM complex | TBar | R-HSA-1362277 (Reactome) | ||
DYRK1A | mim-catalysis | R-HSA-1362270 (Reactome) | ||
E2F1 targets | Arrow | R-HSA-539107 (Reactome) | ||
E2F1:TFDP1 | Arrow | R-HSA-539107 (Reactome) | ||
E2F1:TFDP1 | R-HSA-113643 (Reactome) | |||
E2F1 | Arrow | R-HSA-1362277 (Reactome) | ||
E2F1 | Arrow | R-HSA-1362300 (Reactome) | ||
E2F4/5:DP1/2 | Arrow | R-HSA-1226094 (Reactome) | ||
E2F4:TFDP1,TFDP2 | Arrow | R-HSA-1226095 (Reactome) | ||
H2O | R-HSA-1363274 (Reactome) | |||
H2O | R-HSA-1363276 (Reactome) | |||
H2O | R-HSA-69199 (Reactome) | |||
HDAC1:RBL1:E2F4:TFDP1,TFDP2 | Arrow | R-HSA-1227671 (Reactome) | ||
HDAC1:RBL1:E2F4:TFDP1,TFDP2 | TBar | R-HSA-1362300 (Reactome) | ||
HDAC1:RBL2:E2F4/5:DP1/2 | Arrow | R-HSA-1227670 (Reactome) | ||
HDAC1:RBL2:E2F4/5:DP1/2 | TBar | R-HSA-1362300 (Reactome) | ||
HDAC1 | R-HSA-1227670 (Reactome) | |||
HDAC1 | R-HSA-1227671 (Reactome) | |||
INK4A | R-HSA-182594 (Reactome) | |||
MCM10 | R-HSA-68919 (Reactome) | |||
MYBL2 | Arrow | R-HSA-1362300 (Reactome) | ||
Mcm10:active
pre-replicative complex | Arrow | R-HSA-68940 (Reactome) | ||
Mcm10:active
pre-replicative complex | R-HSA-68918 (Reactome) | |||
Mcm10:pre-replicative complex | Arrow | R-HSA-68919 (Reactome) | ||
Mcm10:pre-replicative complex | R-HSA-68940 (Reactome) | |||
Mcm2-7 complex | R-HSA-68954 (Reactome) | |||
MuvB complex | R-HSA-1362270 (Reactome) | |||
Myc/Max heterodimer | Arrow | R-HSA-188345 (Reactome) | ||
ORC:origin:cyclin B:cdk1 complex | Arrow | R-HSA-113638 (Reactome) | ||
ORC:origin | R-HSA-113638 (Reactome) | |||
PCNA | Arrow | R-HSA-1362277 (Reactome) | ||
PKMYT1 | mim-catalysis | R-HSA-69690 (Reactome) | ||
PKMYT1 | mim-catalysis | R-HSA-69691 (Reactome) | ||
PP2A | mim-catalysis | R-HSA-113503 (Reactome) | ||
PP2A | mim-catalysis | R-HSA-1363274 (Reactome) | ||
PP2A | mim-catalysis | R-HSA-1363276 (Reactome) | ||
Pi | Arrow | R-HSA-1363274 (Reactome) | ||
Pi | Arrow | R-HSA-1363276 (Reactome) | ||
Pi | Arrow | R-HSA-69199 (Reactome) | ||
R-HSA-113503 (Reactome) | At the beginning of this reaction, 1 molecule of 'phospho-Retinoblastoma protein', and 1 molecule of 'RNA primer-DNA primer:origin duplex with DNA damage' are present. At the end of this reaction, 1 molecule of 'Rb1:RNA primer-DNA primer:origin duplex with DNA damage' is present. This reaction takes place in the 'nucleus' and is mediated by the 'phosphoprotein phosphatase activity' of 'PP2A'. | |||
R-HSA-113504 (Reactome) | At the beginning of this reaction, 1 molecule of 'RNA primer-DNA primer:origin duplex' is present. At the end of this reaction, 1 molecule of 'DNA polymerase alpha:primase', and 1 molecule of 'RNA primer-DNA primer:origin duplex with DNA damage' are present. This reaction takes place in the 'nucleus'. | |||
R-HSA-113505 (Reactome) | At the end of this reaction, 1 molecule of 'Cyclin B:Cdk1 complex', and 1 molecule of 'Cdc25A' are present. This reaction takes place in the 'nucleus'. | |||
R-HSA-113638 (Reactome) | This event is inferred from the fission yeast. Cyclin B activity is thought to inhibit pre-RC formation by first associating with ORC during DNA replication. | |||
R-HSA-113643 (Reactome) | This set of events is inferred from annotated events in Drosophila. Rb1 is normally hyperphosphorylated by CycD/CDK4/CDK6 and Cyclin E/CDK2 for transition into S-phase. PP2A can then reverse this reaction, in this case, in response to DNA damage induced checkpoint. | |||
R-HSA-1226094 (Reactome) | At G1 entry from G0, p130 (RBL2) is phosphorylated on three threonine and serine residues by cyclin D1 dependent kinases CDK4 and/or CDK6, leading to dissociation of p130 (RBL2) from complexes it formed with E2F4 or E2F5 and DP1 or DP2. This is thought to promote translocation of E2F4 and E2F5, which lack nuclear localization signals, to the cytosol, allowing activating E2Fs (E2F1, E2F2 and E2F3) to bind E2F promoters and activate transcription of genes needed for G1 progression. | |||
R-HSA-1226095 (Reactome) | In late G1, cyclin D dependent kinases CDK4 and CDK6 phosphorylate RBL1 (p107) on four serine and threonine residues (S964, S975, T369 and S640), leading to dissociation of phosphorylated RBL1 (p107) from E2F4 in complex with either DP-1 or DP-2. E2F4, which lacks nuclear localization signal, is then thought to translocate to the cytosol, allowing E2F promoter sites to become occupied by activating E2Fs (E2F1, E2F2, and E2F3), resulting in transcription of E2F targets needed for cell cycle progression. | |||
R-HSA-1227670 (Reactome) | p130 (RBL2) in complex with E2F4 or E2F5 and DP1 or DP2 recruits histone deacetylase HDAC1, probably in complex with other chromatin modification factors, and represses transcription of E2F target promoters during G0 in quiescent cells. | |||
R-HSA-1227671 (Reactome) | p107 (RBL1) in complex with E2F4 and DP1 or DP2 recruits histone deacetylase HDAC1 (possibly in complex with other chromatin modification proteins) through LXCXE-like motif, shared by pocket proteins, to repress transcription of E2F target genes in early G1. | |||
R-HSA-1362261 (Reactome) | In G0 and early G1, p130 (RBL2) bound to E2F4 or E2F5 and DP1 or DP2 associates with the MuvB complex, consisting of LIN9, LIN37, LIN52, LIN54 and RBBP4 to form evolutionarily conserved DREAM complex. Phosphorylation of LIN52 on serine residue S28 is critical for association of MuvB complex with p130 (RBL2). | |||
R-HSA-1362270 (Reactome) | LIN52 subunit of MuvB complex is phosphorylated by the protein kinase DYRK1A on the serine residue S28, promoting association of MuvB with p130 (RBL2). From model organism studies, DYRK proteins are known to function in cell cycle regulation, differentiation and stress response. | |||
R-HSA-1362277 (Reactome) | DREAM complex is evolutionarily conserved and is reponsible for transcriptional repressession of cell cycle-regulated genes in G0 and early G1. | |||
R-HSA-1362300 (Reactome) | In G0 and early G1, expression of E2F target genes such as Cyclin A, E2F1, CDC2 and MYBL2 is inhibited by complexes containing p130 (RBL2) and p107 (RBL1), respectively, and histone deacetylase HDAC1. | |||
R-HSA-1363274 (Reactome) | Dephosphorylation of p107 (RBL1) by PP2A complex containing either PPP2R3B (B" beta) or PPP2R2A (B alpha) regulatory subunit plays a role in maintaining the equilibrium of hyperphosphorylated and hypophosphorylated p107 (RBL1), through counteracting action of cyclin dependent kinases (CDKs) throughout the cell cycle. It is assumed that PP2A dephosphorylates p107 (RBL1) on all four phosphorylation sites, but further experiments are needed to confirm this. | |||
R-HSA-1363276 (Reactome) | Dephosphorylation of p130 (RBL2) by PP2A complex containing either PPP2R3B (B" beta) or PPP2R2A (B alpha) regulatory subunit plays a role in maintaining the equilibrium of hyperphosphorylated and hypophosphorylated p130 (RBL2), through counteracting action of cyclin dependent kinases (CDKs). It is assumed that PP2A dephosphorylates p130 (RBL2) on all three phosphorylation sites, but further experiments are needed to confirm this. | |||
R-HSA-1363303 (Reactome) | p130 (RBL2) in complex with E2F4/5 and DP1/2 binds to cyclin A or cyclin E in complex with CDK2 through its conserved LFG pocket domain motif and amino terminus, leading to inhibition of CDK2 kinase activity and suppression of cellular growth. | |||
R-HSA-1363306 (Reactome) | p130 (RBL2) is able to bind complexes of CDK2 with either cyclin A or cyclin E through the cyclin-binding LFG motif within the pocket domain, which is conserved in p107 (RBL1) and p21/WAF1/Cip1 family of cyclin-dependent kinases. In addition to LFG motif, amino terminal region of p130 (RBL2), conserved in p107 (RBL1), is necessary for inhibition of CDK2 kinase activity. Presence of E2F is not required for this interaction. | |||
R-HSA-1363311 (Reactome) | p107 (RBL1) in complex with E2F4 and DP1/2 binds to cyclin A or cyclin E in complex with CDK2 through its conserved LFG pocket domain motif and amino terminus, leading to inhibition of CDK2 kinase activity and suppression of cellular growth. | |||
R-HSA-1363314 (Reactome) | p107 (RBL1) is able to bind complexes of CDK2 with either cyclin A or cyclin E, through cyclin-binding LFG motif in the pocket domain, which is conserved in p130 (RBL2) and p21/WAF1/Cip1 family of cyclin-dependent kinase inhibitors. In addition to the LFG motif, the amino terminal sequence conserved in the p107 (RBL1) and p130 (RBL2) is needed for inhibition of CDK2 kinase activity. Presence of E2F is not required for this interaction. | |||
R-HSA-1363328 (Reactome) | Phosphorylated p130 (RBL2) binds SCF (Skp2) ubiquitin ligase in complex with Cks1. Phosphorylation of p130 (RBL2) serine residue S672 by CDK4/6 is critical for this interaction. | |||
R-HSA-1363331 (Reactome) | As quiescent G0 cells reenter the cell cycle, p130 (RBL2) is phosphorylated by CDK4/6. This phosphorylated p130 (RBL2) binds ubiquitin ligase SCF (Skp2) in complex with Cks1, and is subsequently ubiquitinated and degraded similarly to p27, which is another target of SCF (Skp2). | |||
R-HSA-141299 (Reactome) | Cyclin D:CDK4/6 complexes translocate to the nucleus from the cytoplasm, and this nuclear accumulation is directed by p21/p27 (LaBaer et al. 1997). | |||
R-HSA-157906 (Reactome) | Follow their formation, the Cyclin E:Cdk2 complexes are translocated to the nucleus. | |||
R-HSA-182594 (Reactome) | Prior to mitogen activation, the inhibitory proteins, INK4 (p15, p16, p18, and p19) associate with the catalytic domain of free CDK4/6, preventing its association with cyclins, and thus its activation. | |||
R-HSA-187506 (Reactome) | p27 translocates to the nucleoplasm where it associates with CyclinE:Cdk2 complexes. Localization of p27 to the nucleus is necessary to inhibit Cdk activation by Cdk-activating kinase. | |||
R-HSA-187520 (Reactome) | The interaction between the Skp2 subunit of the SCF(Skp2) complex and p27 is dependent upon Cdk2:Cyclin A/E mediated phosphorylation of p27 at Thr 187 (Carrano et al, 1999; Tsvetkov et al, 1999). There is evidence that Cyclin A/B:Cdk1 can also bind and phosphorylate p27 on Thr 187 (Nakayama et al., 2004). This phosphorylation is also essential for the subsequent ubiquitination of p27. | |||
R-HSA-187545 (Reactome) | The accessory protein, Cks1 promotes efficient interaction between phosphorylated p27 and the SCF (Skp2) complex (Ganoth et al., 2001; Spruck et al., 2001). Cks1 binds to Skp2 in the leucine-rich repeat (LRR) domain and C-terminal tail (Hao et al., 2005). The phosphorylated Thr187 side chain of p27 associates with a phosphate binding site on Cks1, and the side chain containing Glu185 is positioned in the interface between Skp2 and Cks1 where it interacts with both (Hao et al., 2005). | |||
R-HSA-187552 (Reactome) | The association of Cks1 with both Skp2 and phosphorylated p27 promotes a tight interaction between p27 and the SCF complex (Hao et al., 2005). | |||
R-HSA-187574 (Reactome) | Following ubiquitination by the SCF(Skp2):Cks1 complex, phospho-p27/p21 is degraded by the 26S proteasome. | |||
R-HSA-187575 (Reactome) | Once in tight contact with the SCF (Skp2):Cks1 complex, phosphorylated p27/p21 is ubiquitinated. | |||
R-HSA-187828 (Reactome) | p21 associates with and inhibits Cyclin:Cdk complexes in the nucleus. | |||
R-HSA-188345 (Reactome) | The Myc/Max heterodimer binds to elements in the cdc25A gene and activates transcription in mid to late G1. | |||
R-HSA-188350 (Reactome) | Phosphorylation of cyclin-dependent kinases (CDKs) by the CDK-activating kinase (CAK) is required for the activation of the CDK kinase activity. The association of p21/p27 with the Cyclin A/E:Cdk2 complex prevents CAK mediated phosphorylation of Cdk2 (Aprelikova et al., 1995). | |||
R-HSA-188386 (Reactome) | pRB contains, in its C terminus, a cyclin-cdk interaction motif like that found in E2F1 and p21 that enables it to be recognized and phosphorylated by cyclin-cdk complexes. | |||
R-HSA-188390 (Reactome) | Cyclin E forms a complex with cdk2 and collaborates with the cyclin D-dependent kinases in phosphorylating Rb. | |||
R-HSA-539107 (Reactome) | E2F1 binds to E2F binding sites on the genome activating the synthesis of the target proteins. For annotation purposes, the reactions regulated by E2F1 are grouped under this pathway and information about the target genes alone are displayed for annotation purposes. Cellular targets for activation by E2F1 include thymidylate synthetase, Rir2, Dihydrofolate reductase, Cdc2, Cyclin A1, Cdc6 (DeGregori et al., 1995), Cdt1 (Yoshida and Inoue, 2004), CDC45 (Arata et al., 2000), CDC6 (Yan et al., 1998; Ohtani et al., 1998), Cyclin E (Ohtani et al., 1996), Emi1 (Hsu et al., 2002), and Orc1 (Ohtani et al., 1997). The activation of TK2 (Dnk1) and Cdc25A by E2F1 have been inferred from similar events in Drosophila (Duronio and O'Farrell, 1994;Reis and Edgar, 2004). Rir2 protein is involved in dNTP level regulation and activation of this enzyme results in higher levels of dNTPs in anticipation of S-phase. E2F activation of Rir2 has been shown also in Drosophila by Duronio and O'Farrell (1994). E2F1 activation of CDC45 is shown in mouse cells by using human E2F1 construct (Arata et al., 2000). Cyclin E is also transcriptionally regulated by E2F1. Cyclin E protein plays important role in the transition of G1 in S-phase by associating with Cdk2 (Ohtani et al., 1996). E2F activation of PCNA has been demonstrated in Drosophila (DeGregori et al., 1995) and in some human cells by using recombinant adenovirus constructs. E2F activation of Polymerase A (Pol A) has been demonstrated in some human cells. It has also been demonstrated in Drosophila by Ohtani and Nevins (1994). It has been observed in Drosophila that E2F1 regulated expression of Orc1 stimulates ORC1-6 complex formation and binding to the origin of replication (Asano and Wharton, 1999). Orc1-6 recruit Cdc6 and Cdt1 that are required to recruit the MCM2-7 replication helicases. E2F1 regulation incorporates a feedback mechanism where in Geminin can inhibit MCM2-7 recruitment of ORC1-6 complex by interacting with Cdc6/Cdt1. The activation of Cdc25A and TK2 (Dnk1) by E2F1 has been inferred from similar events in Drosophila (Duronio RJ, O'Farrell 1994; Reis and Edgar, 2004). E2F1 activates string (Cdc25) that in turn activates Cyclin B/Cdk1. A similar phenomenon has been observed in mouse NIH 3T3 cells and in Rat1 cells. | |||
R-HSA-68914 (Reactome) | DNA polymerase alpha:primase is comprised of four subunits, p180, p70, p58, and p49. The two primase subunits, p58 and p49, form a tight complex. The p49 subunit contains the DNA primase activity and one role of p58 appears to be tethering p49 to p180, the DNA polymerase catalytic subunit. The fourth subunit, p70, binds p180 and may tether the DNA polymerase alpha:primase complex to Cdc45. | |||
R-HSA-68916 (Reactome) | After pre-RC assembly and Cdc45 association with the origin of replication, Replication Protein A (RPA) also associates with chromatin. RPA is a heterotrimeric complex containing p70, p34, and p11 subunits, and also is required for DNA recombination and DNA repair. The p70 subunit of RPA binds to the primase subunits of Pol alpha:primase. The p70 and p34 subunits of RPA are phosphorylated in a cell cycle-dependent manner. RPA is a single-strand DNA (ssDNA) binding protein and its association with chromatin at this stage suggests that DNA is partially unwound. This suggestion has been confirmed by detection of ssDNA in budding yeast origins of replication using chemical methods. | |||
R-HSA-68917 (Reactome) | Once the Mcm2-7 complex has been assembled onto the origin of replication, the next step is the assembly of Cdc45, an essential replication protein, in late G1. The assembly of Cdc45 onto origins of replication forms a complex distinct from the pre-replicative complex, sometimes called the pre-initiation complex. The assembly of Cdc45 onto origins correlates with the time of initiation. Like the Mcm2-7 proteins, Cdc45 binds specifically to origins in the G1 phase of the cell cycle and then to non-origin DNA during S phase and is therefore thought to travel with the replication fork. Indeed, S. cerevisiae Cdc45 is required for DNA replication elongation as well as replication initiation. Cdc45 is required for the association of alpha DNA polymerase:primase with chromatin. Based on this observation and the observation that in S. cerevisiae, cCdc45 has been found in large complexes with some components of Mcm2-7 complex, it has been suggested that Cdc45 plays a scaffolding role at the replication fork, coupling Pol-alpha:primase to the replication fork through the helicase. Association of Cdc45 with origin DNA is regulated in the cell cycle and its association is dependent on the activity of cyclin-dependent kinases but not the Cdc7/Dbf4 kinase. In Xenopus egg extracts, association of Cdc45 with chromatin is dependent on Xmus101. TopBP1, the human homolog of Xmus1, is essential for DNA replication and interacts with DNA polymerase epsilon, one of the polymerases involved in replicating the genome. TopBP1 homologs have been found in S. cerevisiae and S. pombe. Sld3, an additional protein required for Cdc45 association with chromatin in S. cerevisiae and S. pombe, has no known human homolog. | |||
R-HSA-68918 (Reactome) | At the beginning of this reaction, 1 molecule of 'Mcm10:active pre-replicative complex', 1 molecule of 'DDK', and 1 molecule of 'CDK' are present. At the end of this reaction, 1 molecule of 'CDK:DDK:Mcm10:pre-replicative complex' is present. This reaction takes place in the 'nucleus'. | |||
R-HSA-68919 (Reactome) | MCM10 is required for human DNA replication. In S. cerevisiae, Mcm10, like Mcm2-7, is required for minichromosome maintenance, but Mcm10 has no sequence homology with these other proteins (Merchant et al., 1997). Genetic studies have demonstrated that Mcm10 is required for DNA replication in S. pombe (Aves et al., 1998) and S. cerevisiae cells (Homesley et al., 2000) and immunodepletion of XlMcm10 interferes with DNA replication in Xenopus egg extracts (Wohlschlegel et al., 2002). Human Mcm10 interacts with chromatin in G1 phase and then dissociates during G2 phase. In S. cerevisiae, Mcm10 has been shown to localize to origins during G1 (Ricke and Bielinsky, 2004), and it may stabilize the association of Mcm2-7 with the pre-replicative complex (Sawyer et al., 2004). This timing of association is consistent with studies that demonstrate that, in Xenopus egg extracts, Mcm10 is required for association of Cdc45, but not Mcm2-7 with chromatin. Biochemical evidence that Mcm10 plays a direct role in the activation of the pre-replicative complex includes the requirement for SpMcm10 in the phosphorylation of the Mcm2-7 complex by DDK (Lee et al., 2004) and the fact that SpMcm10 binds and stimulates DNA polymerase alpha activity (Fien et al., 2004). | |||
R-HSA-68940 (Reactome) | At the beginning of this reaction, 1 molecule of 'Mcm10:pre-replicative complex' is present. At the end of this reaction, 1 molecule of 'Mcm10:active pre-replicative complex', and 1 molecule of 'CDT1' are present. This reaction takes place in the 'nucleus'. | |||
R-HSA-68954 (Reactome) | At the beginning of this reaction, 1 molecule of 'Mcm2-7 complex', and 1 molecule of 'ATP' are present. At the end of this reaction, 1 molecule of 'phosphorylated Mcm2-7 complex', and 1 molecule of 'ADP' are present. This reaction takes place in the 'nucleus' and is mediated by the 'kinase activity' of 'DDK'. | |||
R-HSA-68960 (Reactome) | At the beginning of this reaction, 1 molecule of 'origin of replication', and 1 molecule of 'DNA polymerase epsilon' are present. At the end of this reaction, 1 molecule of 'DNA polymerase epsilon:origin complex' is present. | |||
R-HSA-69191 (Reactome) | The E-type cyclins and Cyclin Dependent Kinase 2 control the transition from G1 to S phase. Cdk2 is competent to carry out the necessary reactions only when complexed with Cyclin E. | |||
R-HSA-69195 (Reactome) | Wee1 phosphorylates Cdk2, inhibiting entry into S-phase (Watanabe et al., 1995; Wu et al., 2001). | |||
R-HSA-69199 (Reactome) | Cdc25A dephosphorylates Cdk2 and activates cyclin E-Cdk2 and cyclin A-Cdk2 kinases (Blomberg and Hoffmann, 1999). | |||
R-HSA-69213 (Reactome) | The formation of CyclinD:CDK4/6 complexes is promoted by two proteins, p21Cip1/Waf1 and p27kip1. Activity of the cyclin-dependent kinases 4 and 6 can be inhibited by the binding of several small CDK-inhibitory proteins (CKIs). | |||
R-HSA-69223 (Reactome) | Phosphorylation of CDK4 on Thr172 depends on prior D-type cyclin binding (Bockstaele et al., 2006). | |||
R-HSA-69227 (Reactome) | Cyclin D:Cdk4 mediated phosphorylation of RB1 releases RB1 from the transcriptional regulator E2F and activates E2F function. | |||
R-HSA-69562 (Reactome) | During G1, the activity of cyclin-dependent kinases (CDKs) is kept in check by the CDK inhibitors (CKIs) p27 and p21, thereby preventing premature entry into S phase (see Guardavaccaro and Pagano, 2006). The efficient recognition and ubiquitination of p27 by the SCF(Skp2) complex requires the formation of a trimeric complex containing p27 and cyclin E/A:Cdk2. | |||
R-HSA-69690 (Reactome) | At the beginning of this reaction, 1 molecule of 'ATP', and 1 molecule of 'Cyclin E1:Cdk2 complex' are present. At the end of this reaction, 1 molecule of 'Cyclin E1:phospho-Cdk2 complex', and 1 molecule of 'ADP' are present. This reaction takes place in the 'nucleoplasm' and is mediated by the 'kinase activity' of 'Myt1 kinase'. | |||
R-HSA-69691 (Reactome) | At the beginning of this reaction, 1 molecule of 'Cyclin E2:Cdk2 complex', and 1 molecule of 'ATP' are present. At the end of this reaction, 1 molecule of 'Cyclin E2:phospho-Cdk2 complex', and 1 molecule of 'ADP' are present. This reaction takes place in the 'nucleoplasm' and is mediated by the 'kinase activity' of 'Myt1 kinase'. | |||
RB1 | R-HSA-188386 (Reactome) | |||
RBL1:Cyclin E/A:CDK2 | Arrow | R-HSA-1363314 (Reactome) | ||
RBL1:E2F4:DP1/2:Cyclin E/A:CDK2 | Arrow | R-HSA-1363311 (Reactome) | ||
RBL1:E2F4:TFDP1,TFDP2 | R-HSA-1226095 (Reactome) | |||
RBL1:E2F4:TFDP1,TFDP2 | R-HSA-1227671 (Reactome) | |||
RBL1:E2F4:TFDP1,TFDP2 | R-HSA-1363311 (Reactome) | |||
RBL1 | Arrow | R-HSA-1362277 (Reactome) | ||
RBL1 | Arrow | R-HSA-1363274 (Reactome) | ||
RBL1 | R-HSA-1363314 (Reactome) | |||
RBL2:Cyclin E/A:CDK2 | Arrow | R-HSA-1363306 (Reactome) | ||
RBL2:E2F4/5:DP1/2:Cyclin E/A:CDK2 | Arrow | R-HSA-1363303 (Reactome) | ||
RBL2:E2F4/5:DP1/2 | R-HSA-1226094 (Reactome) | |||
RBL2:E2F4/5:DP1/2 | R-HSA-1227670 (Reactome) | |||
RBL2:E2F4/5:DP1/2 | R-HSA-1362261 (Reactome) | |||
RBL2:E2F4/5:DP1/2 | R-HSA-1363303 (Reactome) | |||
RBL2 | Arrow | R-HSA-1363276 (Reactome) | ||
RBL2 | R-HSA-1363306 (Reactome) | |||
RNA primer-DNA
primer:origin duplex with DNA damage | Arrow | R-HSA-113504 (Reactome) | ||
RNA primer-DNA
primer:origin duplex with DNA damage | R-HSA-113503 (Reactome) | |||
RNA primer-DNA
primer:origin duplex | R-HSA-113504 (Reactome) | |||
RPA:Cdc45:CDK:DDK:Mcm10:pre-replicative complex | Arrow | R-HSA-68914 (Reactome) | ||
RPA:Cdc45:CDK:DDK:Mcm10:pre-replicative complex | Arrow | R-HSA-68916 (Reactome) | ||
RPA:Cdc45:CDK:DDK:Mcm10:pre-replicative complex | Arrow | R-HSA-68960 (Reactome) | ||
Rb-E2F1/2/3:DP-1 complex | R-HSA-69227 (Reactome) | |||
Rb1:RNA primer-DNA
primer:origin duplex with DNA damage | Arrow | R-HSA-113503 (Reactome) | ||
Rb1:RNA primer-DNA
primer:origin duplex with DNA damage | R-HSA-113643 (Reactome) | |||
SCF(Skp2) complex | R-HSA-187545 (Reactome) | |||
SCF(Skp2):Cks1 complex | Arrow | R-HSA-1363331 (Reactome) | ||
SCF(Skp2):Cks1 complex | Arrow | R-HSA-187545 (Reactome) | ||
SCF(Skp2):Cks1 complex | Arrow | R-HSA-187574 (Reactome) | ||
SCF(Skp2):Cks1 complex | R-HSA-1363328 (Reactome) | |||
SCF(Skp2):Cks1 complex | R-HSA-187552 (Reactome) | |||
TOP2A | Arrow | R-HSA-1362277 (Reactome) | ||
Ub-p-T401,S672,1035-RBL2 | Arrow | R-HSA-1363331 (Reactome) | ||
WEE1 | mim-catalysis | R-HSA-69195 (Reactome) | ||
origin of replication | R-HSA-68960 (Reactome) | |||
p-MuvB complex | Arrow | R-HSA-1362270 (Reactome) | ||
p-MuvB complex | R-HSA-1362261 (Reactome) | |||
p-S795-RB1 | Arrow | R-HSA-69227 (Reactome) | ||
p-S795-RB1 | R-HSA-113503 (Reactome) | |||
p-T369,S640,S964,S975-RBL1 | Arrow | R-HSA-1226095 (Reactome) | ||
p-T369,S640,S964,S975-RBL1 | R-HSA-1363274 (Reactome) | |||
p-T401,S672,1035-RBL2:SCF(Skp2):Cks1 | Arrow | R-HSA-1363328 (Reactome) | ||
p-T401,S672,1035-RBL2:SCF(Skp2):Cks1 | R-HSA-1363331 (Reactome) | |||
p-T401,S672,1035-RBL2:SCF(Skp2):Cks1 | mim-catalysis | R-HSA-1363331 (Reactome) | ||
p-T401,S672,S1035-RBL2 | Arrow | R-HSA-1226094 (Reactome) | ||
p-T401,S672,S1035-RBL2 | R-HSA-1363276 (Reactome) | |||
p-T401,S672,S1035-RBL2 | R-HSA-1363328 (Reactome) | |||
p21/p27 | R-HSA-69213 (Reactome) | |||
p21/p27 | R-HSA-69562 (Reactome) | |||
p21/p27 | mim-catalysis | R-HSA-69562 (Reactome) | ||
phosphorylated Mcm2-7 complex | Arrow | R-HSA-68954 (Reactome) | ||
pre-replicative complex | R-HSA-68919 (Reactome) | |||
ubiquitin | Arrow | R-HSA-187574 (Reactome) | ||
ubiquitin | R-HSA-1363331 (Reactome) | |||
ubiquitin | R-HSA-187575 (Reactome) |