Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)

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32, 50, 51, 7035, 62, 698, 27, 43, 792, 24, 8312, 2614, 23, 39955, 715, 634, 298025, 54, 5611, 4044, 8028, 52761615, 1862, 6945, 49, 51, 53, 661, 5719, 20, 30, 48, 60...21, 46, 65, 68, 86...7, 42, 5967, 8238, 8536, 771610, 9010, 29, 33, 78, 88...31, 6113, 34, 37, 58, 74...3, 226, 41, 8947, 72, 767542, 59cytosolphagocytic cupendoplasmic reticulum lumenIg heavy chain V-Iregion HG3 Ig lambda chain V-VIregion EB4 Ig heavy chain V-IIIregion GAL Ig heavy chain V-IIIregion BUR Ig kappa chain V-IIIregion VH Ig kappa chain V-IIIregion IARC/BL41 RAC1 IGHV(1-?) IGLV3-12(1-?) Ig kappa chain V-Iregion Wes IGLV1-36(1-?) IGLV3-16(1-?) Ig kappa chain V-Iregion Walker ATP Ig lambda chain V-IVregion Kern Ig heavy chain V-Iregion SIE Ig lambda chain V-IVregion Kern Ig kappa chain V-Iregion EU Ig lambda chain V-Iregion VOR Ig kappa chain V-IIIregion CLL Ig lambda chain V-IIregion NIG-84 IGLV3-25(1-?) Ig heavy chain V-Iregion ND IGHG4 RAC1/CDC42:p-S144,T423-PAKIGLV5-37(1-?) RAC1 BAIAP2IGHG4 NCKAP1 p-6Y-CD247-1 Ig lambda chain V-Vregion DEL IGHG1 Ig heavy chain V-IIIregion DOB IGHV(1-?) Ig lambda chain V-Iregion WAH Ig lambda chain V-Iregion NEW PI(4,5)P2Ig kappa chain V-IIIregion Ti Ig kappa chain V-Iregion Hau Ig lambda chain V-Vregion DEL Ig heavy chain V-IIIregion GAL IGLV2-11(1-?) Ig heavy chain V-IIIregion TRO IGLV5-45(1-?) Ig lambda chain V-IVregion MOL Ig kappa chain V-Iregion OU ACTG1 CD3G IGLV4-69(1-?) IGLV11-55(1-?) IGLV5-37(1-?) Ig lambda chain V-IIregion TRO IGLV2-18(1-?) Ig kappa chain V-IIIregion GOL Ig lambda chain V-IVregion MOL Ig heavy chain V-IIIregion TUR Ig heavy chain V-IIIregion CAM IGKC p-Y291-WAS NCKAP1 IGLV5-45(1-?) Ig kappa chain V-Iregion Bi Ig heavy chain V-IIIregion POM Ig heavy chain V-IIregion NEWM Ig kappa chain V-Iregion Rei IGLV3-16(1-?) IGLC7 Ig kappa chain V-Iregion WEA Ig heavy chain V-IIIregion TIL CDC42:GTP:WASP/N-WASPIg kappa chain V-Iregion BAN Ig heavy chain V-IIIregion NIE IGLV7-46(1-?) Ig heavy chain V-IIregion WAH p-6Y-CD247-1 RAC1/CDC42:PAK dimerIg heavy chain V-Iregion SIE Ig kappa chain V-Iregion Lay Ig kappa chain V-Iregion Kue ELMO2 Ig kappa chain V-Iregion Wes Ig lambda chain V-IIregion BOH p-6Y-SYK Ig kappa chain V-IIIregion WOL Ig lambda chain V-Iregion BL2 GRB2-1 Ig lambda chain V-Iregion BL2 PI(3,4,5)P3 IGLV4-3(1-?) p-6Y-CD247-1 IGLV2-23(1-?) Ig heavy chain V-IIIregion CAM IGLV4-3(1-?) IGLV4-69(1-?) Ig heavy chain V-Iregion SIE Ig heavy chain V-IIregion NEWM Ig lambda chain V-IIregion BO Ig kappa chain V-Iregion Walker Ig kappa chain V-IVregion JI Ig heavy chain V-IIIregion BUT Ig heavy chain V-Iregion Mot Ig heavy chain V-Iregion EU Ig lambda chain V-IIregion TRO Ig kappa chain V-IIIregion HAH IGLV5-45(1-?) IGLV5-45(1-?) Ig kappa chain V-Iregion Gal CYFIP1 Ig lambda chain V-Iregion WAH Ig heavy chain V-Iregion SIE p-Y288,Y304-FCGR2A IGLV3-27(1-?) Ig heavy chain V-IIIregion ZAP Ig heavy chain V-IIIregion GA Ig heavy chain V-Iregion SIE IGLV1-36(1-?) Ig kappa chain V-IIIregion CLL PI(4,5)P2 Ig heavy chain V-IIregion NEWM Ig heavy chain V-Iregion WOL Ig heavy chain V-IIregion COR Ig kappa chain V-IIIregion WOL p-Y288,Y304-FCGR2A ACTG1 Ig lambda chain V-VIregion AR Ig lambda chain V-IVregion Hil Ig heavy chain V-IIIregion DOB Ig heavy chain V-IIIregion TIL ARPC3 Ig heavy chain V-IIregion OU Ig lambda chain V-IIregion MGC Ig lambda chain V-IIregion WIN Ig heavy chain V-IIIregion KOL Ig kappa chain V-IIIregion Ti Ig kappa chain V-IVregion JI IGLV2-18(1-?) I(1,4,5)P3Ig kappa chain V-IVregion B17 IGLV4-69(1-?) Ig kappa chain V-IIregion FR IGKVA18(21-?) IGLV(23-?) Ig kappa chain V-IIIregion WOL Ig heavy chain V-IIIregion TRO IGLC6 Ig kappa chain V-Iregion Daudi Ig lambda chain V-IIregion VIL Ig heavy chain V-IIIregion BUT CYFIP2 IGLV3-12(1-?) Ig heavy chain V-IIIregion NIE Ig kappa chain V-Iregion Wes Ig kappa chain V-IIregion MIL Antigen-antibodycomplexIg kappa chain V-Iregion DEE Ig heavy chain V-IIIregion GA Ig heavy chain V-IIIregion POM Ig lambda chain V-IIregion NIG-84 Ig heavy chain V-IIregion HE Ig heavy chain V-Iregion WOL Ig heavy chain V-IIIregion KOL Ig lambda chain V-Iregion NEW Ig kappa chain V-IIIregion HAH p-Y291-WAS Ig heavy chain V-Iregion Mot Ig lambda chainV-III region LOI IgH heavy chainV-III region VH26precursor Ig kappa chain V-Iregion Lay Ig kappa chain V-Iregion BAN Ig kappa chain V-IIIregion VG Ig kappa chain Vregion EV15 IGLV2-33(1-?) IGLV2-33(1-?) Ig kappa chain V-IIregion Cum Ig kappa chain V-IIregion RPMI 6410 Ig kappa chain V-Iregion DEE Ig lambda chain V-IIregion WIN IgH heavy chainV-III region VH26precursor Ig heavy chain V-IIregion DAW Ig lambda chain V-Iregion NEW Ig lambda chain V-Iregion HA Ig lambda chainV-III region SH Ig kappa chain V-IIregion Cum Ig kappa chain V-Iregion Ni IGKV4-1(21-?) Ig kappa chain V-IIregion GM607 p-4Y-PLCG1 IGLV10-54(1-?) IGHG4 IGLV4-60(1-?) Ig kappa chain V-Iregion Lay Ig lambda chain V-Iregion NEWM Ig heavy chain V-IIIregion POM CDC42:GDPIg lambda chain V-IVregion Bau Ig lambda chainV-III region SH IGKVA18(21-?) IGLV8-61(1-?) Ig kappa chain V-IVregion STH p-Y288,Y304-FCGR2A Ig heavy chain V-IIIregion TUR Ig lambda chain V-IIregion BO Ig heavy chain V-IIIregion BRO IGLV5-37(1-?) Ig kappa chain V-Iregion Ka IGLV4-3(1-?) IGLV5-45(1-?) FCGR3A Ig heavy chain V-Iregion HG3 Ig lambda chain V-IIregion BO Ig kappa chain V-Iregion Bi Ig lambda chain V-IIregion BOH Ig kappa chain V-Iregion Ka Ig heavy chain V-IIregion HE Ig lambda chain Vregion 4A Ig lambda chain V-Iregion NEWM p-Y288,Y304-FCGR2A Ig kappa chain V-Iregion AU Ig kappa chain V-IIIregion SIE Ig lambda chain V-IIregion BO IGKV1-5(23-?) Ig heavy chain V-Iregion EU IGLV10-54(1-?) ITPR1 Ig lambda chain V-VIregion SUT Ig heavy chain V-IIIregion LAY Ig heavy chain V-IIIregion GAL IGLC1 Ig lambda chain V-Iregion HA IGLV7-43(1-?) IGLV7-46(1-?) Ig kappa chain V-IIIregion B6 Ig heavy chain V-IIregion COR IGKVA18(21-?) Ig heavy chain V-IIIregion TEI Ig lambda chain V-IIregion TOG IGLV2-23(1-?) IGLV1-40(1-?) Ig heavy chain V-IIregion ARH-77 Ig heavy chain V-IIIregion JON IGLC6 Ig kappa chain V-Iregion Wes Ig kappa chain V-IIregion FR WIPF1 Ig kappa chain V-IIIregion B6 Ig kappa chain V-IIIregion CLL Ig kappa chain V-Iregion CAR IGKVA18(21-?) Ig lambda chain V-Iregion BL2 Ig lambda chain V-VIregion SUT Ig heavy chain V-Iregion Mot Ca2+PI(3,4,5)P3 Ig lambda chain V-Iregion NEW PLC gamma1,2Ig heavy chain V-IIIregion JON Ig kappa chain V-IVregion STH Ig heavy chain V-IIIregion TUR Ig heavy chain V-IIregion COR p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3Ig kappa chain V-Iregion Ka IGLV3-25(1-?) Ig lambda chain V-Iregion NEWM Ig heavy chain V-IIIregion BUR IGKVA18(21-?) Ig kappa chain V-Iregion OU IGLV2-33(1-?) Ig kappa chain V-IIregion RPMI 6410 Ig kappa chain V-IIIregion SIE p-Y160,Y171-CD3G p-Y288,Y304-FCGR2A Ig kappa chain V-IIIregion HAH Ig heavy chain V-IIIregion LAY Ig heavy chain V-IIregion MCE IGLV3-25(1-?) p-Y256-WASL Ig heavy chain V-IIIregion TIL IGLV2-11(1-?) GTP MYO10 Ig lambda chain V-Iregion MEM ADPIGLV11-55(1-?) IGKC Ig heavy chain V-Iregion ND Ig lambda chain V-IIregion TOG Ig heavy chain V-IIIregion ZAP IGHG3 CYFIP2 IGLV3-12(1-?) Ig lambda chain V-Iregion BL2 IGLV7-43(1-?) Ig lambda chain V-IIregion BO IGLV3-27(1-?) IGHG2 Ig kappa chain V-IIIregion HIC NCKAP1L ARPC5 Ig lambda chainV-III region SH Ig kappa chain V-IIIregion CLL IGLV3-27(1-?) Ig kappa chain V-Iregion Mev Ig kappa chain V-Iregion AG Ig lambda chain V-IIregion WIN FCGR1A Ig kappa chain V-Iregion Walker GTP Ig lambda chain V-Iregion NIG-64 ARPC4 ACTR2 NCK1 clusteredIgG-Ag:p-FCGRs:p-6Y-SYKIg kappa chain V-Iregion HK101 Ig kappa chain V-IVregion Len IGLV3-25(1-?) Ig kappa chain V-Iregion Gal Ig heavy chain V-IIregion NEWM Ig lambda chain V-VIregion WLT Ig heavy chain V-Iregion ND Ig lambda chain V-Iregion WAH IGKVA18(21-?) IGLV2-33(1-?) Ig kappa chain V-Iregion CAR Ig kappa chain V-IVregion B17 IGLV7-43(1-?) Ig kappa chain V-IIIregion GOL Ig lambda chainV-III region SH IGLV10-54(1-?) Ig lambda chain V-IIregion WIN Ig lambda chain V-VIregion EB4 IGLC1 Ig kappa chain V-IIIregion CLL CYFIP1 IGLV11-55(1-?) Ig kappa chain V-IVregion STH Ig kappa chain V-Iregion Gal Ig kappa chain V-Iregion Roy Ig lambda chain V-IVregion Bau Ig heavy chain V-IIIregion DOB AHCYL1 IGHG3 FCGR3A Ig lambda chain V-Iregion MEM IGKV1-5(23-?) Ig lambda chain V-Iregion NIG-64 Ig kappa chain V-Iregion Bi Ig kappa chain V-IIIregion Ti Ig heavy chain V-IIregion OU Ig lambda chain V-Iregion VOR Ig lambda chain V-IIregion WIN Ig heavy chain V-IIIregion BUT IGLV2-18(1-?) Ig lambda chain V-IVregion Hil Ig heavy chain V-IIregion COR Ig kappa chain V-Iregion Hau Ig lambda chain V-IIregion BO Ig heavy chain V-IIregion ARH-77 HSP90AB1 Ig kappa chain V-Iregion Hau IGLV7-46(1-?) IGKV4-1(21-?) Ig kappa chain V-Iregion DEE Ig heavy chain V-IIIregion LAY Ig kappa chain V-Iregion WAT Ig heavy chain V-IIregion DAW RAC1 Ig kappa chain V-Iregion DEE WIPF3 Ig lambda chain V-IVregion MOL Ig lambda chain V-Iregion WAH FCGR3A Ig heavy chain V-Iregion WOL Ig heavy chain V-IIIregion WAS Ig heavy chain V-IIregion SESS IGHG1 Ig heavy chain V-IIIregion NIE Ig kappa chain Vregion EV15 Ig kappa chain V-IIregion TEW ACTR2 Ig kappa chain V-Iregion BAN ITPR2 Ig heavy chain V-Iregion EU Ig heavy chain V-IIIregion WAS Ig lambda chain V-IVregion Kern RAC1 CYFIP1 p-6Y-CD247-1 Ig kappa chain V-IIIregion VH IGHG3 IGLV2-18(1-?) Ig heavy chain V-IIregion MCE IGLV3-25(1-?) Ig kappa chain V-IIIregion Ti Ig kappa chain V-IIregion TEW FCGR1A Ig lambda chainV-III region SH Ig heavy chain V-IIregion MCE ARARAC1 ATP ARPC1A IGLV2-23(1-?) IGLV7-43(1-?) ARPC4 Ig kappa chain V-IIregion GM607 Ig kappa chain V-Iregion Wes Ig lambda chain V-VIregion AR ARPC4 PI(3,4,5)P3 Ig heavy chain V-IIIregion JON ACTR3 Ig kappa chain V-IIIregion Ti Ig kappa chain V-IIIregion GOL IGKV4-1(21-?) Ig heavy chain V-IIIregion HIL Ig heavy chain V-IIIregion KOL IGLC7 IGLV1-36(1-?) Ig kappa chain V-Iregion Walker Ig heavy chain V-IIIregion JON PIK3CB IGLV3-22(1-?) FCGR3A NCKAP1L IGHG2 IGHG2 Ig kappa chain V-IIIregion IARC/BL41 Ig kappa chain V-IIIregion HAH Ig kappa chain V-Iregion Lay IgG-Ag:FCGRIIIA:CD3G/CD3Z dimersIGLC7 Ig kappa chain V-Iregion WAT Ig kappa chain V-Iregion BAN Ig lambda chain V-IVregion Bau RAC1 IGHV(1-?) Ig lambda chain V-IVregion Bau IGLV4-3(1-?) Ig kappa chain V-Iregion AU ADPIg kappa chain V-Iregion Rei IGLC7 Ig heavy chain V-IIIregion TUR Ig lambda chain V-IVregion MOL PIK3R2 Ig kappa chain V-IIregion RPMI 6410 Ig heavy chain V-IIregion WAH Ig kappa chain V-Iregion OU IGLC2 Ig heavy chain V-IIIregion TRO ACTB(1-375) Ig kappa chain V-IIIregion VG Ig kappa chain V-IIIregion VH Ig kappa chain V-Iregion AU Ig kappa chain V-IIIregion SIE FCGR3A Ig lambda chain V-IVregion Hil Ig heavy chain V-Iregion HG3 Ig lambda chain V-IIregion BO Ig kappa chain V-Iregion CAR Ig lambda chain V-IVregion X Ig kappa chain V-Iregion OU Ig kappa chain V-Iregion Gal PIK3CB PiI(1,4,5)P3 IGHV7-81(1-?) IGLV4-60(1-?) Ig lambda chain V-Iregion NEW IGLC3 WIPF3 IGKC Ig lambda chain V-IIregion NIG-58 ITPR3 IGLV7-46(1-?) Ig kappa chain V-IIIregion NG9 RAC1 ACTB(1-375) FCGR3A WAVE RegulatoryComplexIg kappa chain V-IIIregion IARC/BL41 CRK IGLV2-23(1-?) Ig kappa chain V-IIregion GM607 Ig kappa chain V-Iregion WAT IGKV4-1(21-?) Ig heavy chain V-IIIregion CAM Ig lambda chainV-III region LOI Ig heavy chain V-IIregion NEWM ACTR3 Ig heavy chain V-IIIregion NIE Ig kappa chain V-IIregion FR Ig kappa chain V-Iregion Kue Ig kappa chain V-Iregion EU Ig kappa chain V-IIIregion WOL Ig lambda chain V-IIregion BUR N-WASP Ig lambda chain V-VIregion EB4 IGLC3 Ig kappa chain V-IIregion GM607 Ig heavy chain V-IIregion DAW IGLV8-61(1-?) RAC1:GDPIGLV3-22(1-?) Ig kappa chain V-IIregion TEW IGLV7-46(1-?) Ig kappa chain V-IIIregion SIE Ig heavy chain V-IIIregion TEI p-Y288,Y304-FCGR2A Ig kappa chain V-Iregion Rei Ig heavy chain V-Iregion EU Ca2+Ig heavy chain V-IIIregion GA Ig kappa chain V-Iregion Mev WIPF2 Ig heavy chain V-IIIregion TEI Ig kappa chain V-IIregion FR Ig lambda chain V-Iregion EPS Ig kappa chain V-IIIregion HIC IGHG1 Ig heavy chain V-IIregion DAW IGLV(23-?) Ig kappa chain V-Iregion Hau Ig kappa chain V-Iregion AU ARPC5 Ig heavy chain V-IIregion HE Ig kappa chain V-IIIregion SIE Ig lambda chain V-IIregion BOH Ig kappa chain V-IIIregion HAH Ig heavy chain V-IIIregion BUR Ig kappa chain V-IVregion JI Ig lambda chain V-IIregion MGC IGLV7-43(1-?) Ig kappa chain V-Iregion Lay NCK1 Ig kappa chain V-Iregion BAN Ig heavy chain V-IIIregion TRO Ig kappa chain V-Iregion EU Ig kappa chain V-Iregion Lay Ig kappa chain Vregion EV15 p-PLCGIg kappa chain V-IVregion B17 Ig lambda chain V-VIregion NIG-48 Ig kappa chain V-IIIregion VG Ig heavy chain V-IIIregion JON Ig lambda chain V-IIregion VIL PIK3R1 Ig heavy chain V-Iregion ND Ig heavy chain V-Iregion SIE CYFIP2 Ig kappa chain V-Iregion Scw Ig heavy chain V-IIIregion TIL IGKVA18(21-?) IGLV3-22(1-?) p-T508-LIMK1 Ig kappa chain V-IIregion GM607 IGLV3-25(1-?) Ig heavy chain V-IIIregion TEI Ig kappa chain V-Iregion Hau IGHG4 Ig lambda chain V-IIregion NIG-58 IGLC2 Ig kappa chain V-IIregion TEW Ig heavy chain V-IIregion HE IGLV1-36(1-?) Ig lambda chain V-IIregion BUR Ig heavy chain V-IIIregion BRO FCGR3A IGLV2-23(1-?) Ig lambda chain V-IIregion NIG-84 Ig lambda chain V-Iregion EPS Ig heavy chain V-IIIregion LAY IGLV1-36(1-?) Ig kappa chain V-IIIregion HAH Ig kappa chain V-Iregion Bi Ig heavy chain V-IIIregion TIL Ig kappa chain V-Iregion Ka Ig kappa chain V-Iregion Gal Ig kappa chain V-Iregion WEA Ig heavy chain V-IIregion COR Ig kappa chain V-Iregion BAN ACTG1 IGKV4-1(21-?) Ig lambda chain V-VIregion NIG-48 Ig kappa chain V-Iregion HK101 Ig lambda chain V-Iregion NEWM Ig kappa chain Vregion EV15 Ig heavy chain V-IIIregion CAM IGHV(1-?) Ig kappa chain V-IIIregion POM Ig heavy chain V-Iregion EU Ig kappa chain V-Iregion Daudi Ig lambda chain V-Iregion EPS Ig kappa chain V-Iregion Roy IGLV2-23(1-?) Activated WAVE2 andWASP/N-WASP:ARP2/3complex:G-actinIg lambda chain V-IIregion WIN Ig lambda chain V-IVregion Hil Ig heavy chain V-IIIregion ZAP Ig lambda chain V-IIregion VIL Ig lambda chain V-Iregion VOR Ig kappa chain V-Iregion Roy Ig lambda chain V-IIregion VIL FCGR2AIg kappa chain V-IIIregion GOL GTP Ig lambda chain V-IIregion BUR IGLV1-40(1-?) IGLV2-23(1-?) IGLV5-37(1-?) Ig kappa chain V-Iregion Mev ARPC2 NCKAP1L CYFIP2 Ig kappa chain V-IIIregion WOL IGLV1-44(1-?) Ig heavy chain V-IIregion SESS Ig heavy chain V-IIIregion JON IGKV4-1(21-?) p-S3-CFL1 ACTR2 IGLV2-18(1-?) Ig lambda chain Vregion 4A WASP/N-WASPIg kappa chain V-IVregion B17 Ig kappa chain V-IIregion TEW Ig heavy chain V-Iregion EU Ig kappa chain V-Iregion Rei IGLV3-16(1-?) Ig kappa chain V-IIIregion Ti Ig lambda chain V-Iregion NIG-64 CDC42 Ig kappa chain V-Iregion Hau Ig kappa chain V-Iregion Hau WIPF3 FCGR1A ELMO1 IGLC3 Ig lambda chain V-IIregion VIL CYFIP1 IGLV(23-?) IGLV1-36(1-?) IGLV(23-?) Ig kappa chain V-Iregion CAR IGLV10-54(1-?) IGLV10-54(1-?) Ig lambda chain V-Iregion NEWM IGLV11-55(1-?) CYFIP2 IGKV4-1(21-?) Ig kappa chain V-Iregion Wes Ig lambda chain V-IIregion MGC Ig kappa chain V-Iregion DEE Ig kappa chain V-Iregion Daudi Ig kappa chain V-IIregion TEW Ig heavy chain V-IIregion MCE Ig kappa chain V-IIIregion HAH Ig lambda chainV-VII region MOT Ig heavy chain V-IIregion SESS Ig kappa chain V-IIregion FR Ig kappa chain V-IVregion JI Ig heavy chain V-IIregion OU Ig heavy chain V-IIregion HE Ig kappa chain V-IIregion FR Ig heavy chain V-IIIregion TIL Ig lambda chain V-Iregion WAH Ig heavy chain V-IIIregion NIE Ig kappa chain V-IIIregion CLL IGLV3-16(1-?) Ig heavy chain V-Iregion Mot Ig heavy chain V-IIregion HE Ig lambda chain V-IIregion NEI IGLV1-36(1-?) Ig kappa chain V-IIIregion WOL Ig kappa chain V-Iregion Kue Ig lambda chain V-Iregion EPS Ig lambda chainV-VII region MOT Ig heavy chain V-IIIregion DOB Ig lambda chain V-IIregion BOH Ig kappa chain V-Iregion Ni Ig heavy chain V-IIIregion WEA IGKV1-5(23-?) Ig kappa chain V-IVregion JI Ig kappa chain V-Iregion Bi Ig kappa chain V-Iregion Daudi IGHG1 IGHG1 ABL1IGLV4-60(1-?) Ig lambda chain V-VIregion EB4 IGLV3-16(1-?) WIPF1 Ig kappa chain V-Iregion Roy Ig lambda chain V-VIregion NIG-48 Ig kappa chain V-Iregion HK101 Ig lambda chain V-Iregion HA Ig lambda chainV-III region SH IGLV3-27(1-?) Ig heavy chain V-IIIregion TIL PI(3,4,5)P3NCKIPSD IGLV1-44(1-?) Ig heavy chain V-IIIregion ZAP Ig heavy chain V-IIregion DAW Ig heavy chain V-IIIregion POM IgH heavy chainV-III region VH26precursor Ig lambda chain V-Vregion DEL Ig kappa chain V-IIIregion Ti Ig lambda chain V-Iregion NEWM Ig heavy chain V-IIIregion WEA CYFIP2 Ig kappa chain V-IIIregion B6 IGHV(1-?) Ig kappa chain V-Iregion Walker IGKC Ig kappa chain V-IIIregion POM PKC-delta/epsilonIg heavy chain V-IIIregion LAY PLCG2 p-6Y-CD247-1 IGLV3-12(1-?) Ig lambda chainV-VII region MOT Ig heavy chain V-IIregion OU Ig kappa chain V-IVregion Len IGKC IGLV3-12(1-?) Ig kappa chain V-Iregion Scw Ig lambda chainV-III region LOI WIPF2 IGKC Ig heavy chain V-Iregion ND IGLV4-3(1-?) Ig lambda chain V-IIregion NIG-58 Ig heavy chain V-IIIregion KOL Ig heavy chain V-IIIregion TRO IGLV1-44(1-?) Ig heavy chain V-IIIregion BUT Ig lambda chain V-IVregion Kern Ig kappa chain V-IIIregion GOL Ig lambda chain V-Iregion NEWM Ig kappa chain V-IIregion TEW ATPIg heavy chain V-Iregion HG3 Ig lambda chain V-IVregion X Ig kappa chain V-IIIregion Ti Ig heavy chain V-IIIregion HIL ARPC3 Ig kappa chain V-IIIregion VG IGLV11-55(1-?) Ig kappa chain V-IVregion B17 IGLV2-11(1-?) IGLV1-44(1-?) Ig lambda chain V-Iregion VOR IGKV4-1(21-?) Ig kappa chain V-Iregion Daudi Ig lambda chain V-VIregion WLT Ig heavy chain V-Iregion EU Ig lambda chain V-VIregion SUT Ig kappa chain V-IIIregion POM Ig kappa chain V-IIIregion NG9 IGLV1-44(1-?) CD247-1 Ig lambda chain V-IVregion Kern Ig kappa chain V-Iregion Bi Ig heavy chain V-IIIregion HIL ARPC4 Ig lambda chain V-VIregion WLT Ig lambda chainV-III region SH Ig kappa chain V-Iregion Lay Src family kinases(SFKs)Ig kappa chain V-Iregion AU Ig heavy chain V-IIIregion JON PLCG1 Ig lambda chain V-IVregion Hil Ig lambda chain V-IIregion NEI IGLV4-69(1-?) Ig kappa chain V-Iregion Gal Ig heavy chain V-IIIregion LAY p-Y174-VAV1 Ig kappa chain V-IVregion B17 Ig kappa chain V-IIregion MIL Ig heavy chain V-IIIregion BUR Ig lambda chain V-Iregion HA Ig lambda chain V-VIregion WLT PI(4,5)P2PI3K:p-6Y-SYKIg heavy chain V-Iregion ND NCKIPSD Ig kappa chain Vregion EV15 Ig heavy chain V-Iregion EU Ig kappa chain V-IIregion MIL Ig lambda chainV-VII region MOT Ig lambda chain V-Iregion VOR IGHG2 Ig lambda chain V-Iregion VOR Ig kappa chain V-IIregion RPMI 6410 Ig lambda chain Vregion 4A Ig heavy chain V-IIIregion KOL IGLC7 Ig kappa chain V-IIIregion HIC IGKC PI(3,4)P2 Ig kappa chain V-Iregion WEA Ig heavy chain V-IIregion OU Ig kappa chain V-IVregion B17 Ig kappa chain V-Iregion EU CDC42 p-6Y-SYK Ig lambda chain V-VIregion EB4 Ig kappa chain V-Iregion Ni Ig lambda chain V-IIregion MGC IGLV7-46(1-?) Ig lambda chain V-Iregion EPS IGHV7-81(1-?) Ig heavy chain V-IIregion MCE Ig kappa chain V-Iregion CAR Ig kappa chain V-Iregion HK101 GDPITPR3 Ig kappa chain V-Iregion Bi IGKV4-1(21-?) Ig kappa chain V-Iregion AU IGLV3-22(1-?) IGHG2 SYKIg heavy chain V-IIIregion DOB IGLV10-54(1-?) Ig heavy chain V-IIIregion HIL IGLV5-45(1-?) IGLV(23-?) Ig lambda chain V-IIregion VIL Ig lambda chainV-III region SH FCGR3A Ig lambda chain V-IVregion MOL Motherfilament:ARP2/3:actin:GDPp-Y160,Y171-CD3G Ig heavy chain V-IIIregion CAM Ig kappa chain V-Iregion Lay IGLV10-54(1-?) Ig lambda chain V-IIregion NEI Ig kappa chain V-IVregion JI Ig heavy chain V-IIregion OU Ig heavy chain V-IIIregion KOL FCGR1A IGHG1 Ig lambda chain V-IIregion BO IGLV2-33(1-?) FCGR2A Ig heavy chain V-IIregion WAH Ig heavy chain V-IIIregion DOB Ig kappa chain V-IIIregion SIE Ig heavy chain V-IIIregion DOB Ig heavy chain V-IIIregion BUR Ig lambda chainV-III region SH Ig lambda chain V-Iregion VOR Ig kappa chain V-Iregion Ni Ig kappa chain V-Iregion WEA ARPC2 Ig heavy chain V-IIregion OU Ig kappa chain V-IIIregion POM Ig heavy chain V-IIregion DAW Ig kappa chain V-IIIregion IARC/BL41 IGLV3-16(1-?) IGLC6 Ig lambda chain V-Iregion MEM CDC42 p-Y160,Y171-CD3G IGLV3-22(1-?) CDC42 Ig kappa chain V-IIIregion CLL NCKAP1L IGHG3 G-actinIg kappa chain Vregion EV15 Ig kappa chain V-Iregion Hau IGLV4-60(1-?) IGLC1 FCGR2A IGLC2 IGLV5-45(1-?) Ig heavy chain V-IIregion MCE Ig heavy chain V-IIIregion WAS Ig kappa chain V-Iregion WAT ACTR2 IGLV(23-?) Ig heavy chain V-IIregion DAW IGLC2 Ig lambda chain V-IIregion BUR Ig kappa chain V-IIregion GM607 NCKAP1 Ig kappa chain V-Iregion WAT IGLV7-43(1-?) Ig lambda chain V-IIregion WIN IGKV4-1(21-?) Ig kappa chain V-IIIregion WOL BRK1 Ig kappa chain V-IVregion STH Ig lambda chainV-VII region MOT IGKVA18(21-?) Ig heavy chain V-IIregion DAW Ig heavy chain V-Iregion WOL p-Y291-WAS Ig heavy chain V-IIIregion POM Ig lambda chain V-Iregion EPS Ig lambda chain V-IVregion Hil ITPR1 Ig lambda chainV-III region SH FCGR3A p-6Y-SYK IGLV11-55(1-?) Ig heavy chain V-IIIregion BUT Ig kappa chain V-IVregion JI Ig heavy chain V-IIregion ARH-77 IGLV4-3(1-?) Ig kappa chain V-IIIregion VH IGHV7-81(1-?) Ig lambda chain V-Iregion NEW IGLV3-25(1-?) pLIMK dimer:HSP-90Ig kappa chain V-IVregion JI Ig lambda chain V-IVregion Hil Ig kappa chain V-IIIregion POM Ig lambda chain V-Iregion VOR Ig lambda chain V-Iregion NEW Ig kappa chain V-Iregion Scw Ig kappa chain V-IIregion GM607 Ig lambda chain V-IIregion NIG-84 PI(4,5)P2 Ig kappa chain V-Iregion EU IGLV2-33(1-?) ARPC4 GTP Ig heavy chain V-IIIregion TUR CYFIP2 IGLV4-69(1-?) Ig kappa chain V-Iregion Rei Ig heavy chain V-Iregion SIE Ig lambda chain V-IIregion NIG-84 Ig lambda chain V-IIregion BUR Ig kappa chain Vregion EV15 Ig kappa chain V-Iregion Kue Ig kappa chain V-Iregion CAR PIK3R1 IgH heavy chainV-III region VH26precursor Ig kappa chain V-IIregion MIL IGLV3-27(1-?) IGLC7 Ig lambda chain V-IIregion NIG-84 Ig heavy chain V-IIIregion WAS Ig kappa chain V-Iregion WAT Ig lambda chain V-VIregion AR Ig lambda chainV-VII region MOT Ig lambda chain V-IIregion TOG IGLV1-44(1-?) Ig kappa chain V-Iregion Ni IGLV1-36(1-?) Ig lambda chain V-VIregion NIG-48 Ig lambda chain V-IVregion MOL GRB2-1 Ig kappa chain V-IIIregion VG GTP Ig kappa chain V-IIIregion HIC Ig heavy chain V-IIIregion HIL Ig kappa chain V-IIIregion Ti IP3 receptorhomotetramerIGLV3-27(1-?) Ig kappa chain V-IIIregion POM IGHG3 Ig lambda chain V-Iregion MEM Ig heavy chain V-Iregion HG3 IGKVA18(21-?) Ig kappa chain V-Iregion Daudi Ig heavy chain V-IIIregion TEI ACTG1 IGLV2-23(1-?) IGHG2 Ig kappa chain V-IIIregion B6 Ig lambda chain V-VIregion SUT Ig lambda chain V-IIregion WIN IGLV2-23(1-?) FCGRIIIA:CD3G/CD3ZdimersIg heavy chain V-Iregion WOL Ig kappa chain V-Iregion WAT Ig heavy chain V-IIIregion CAM p-6Y-CD247-1 IGKV1-5(23-?) Ig kappa chain V-Iregion Daudi ACTG1 Ig lambda chain V-VIregion SUT Ig heavy chain V-IIregion SESS Myosin-ActinfilamentsIg lambda chain V-IIregion TRO Ig kappa chain V-IIIregion POM GTP Ig lambda chain V-IIregion BO Ig kappa chain V-IIIregion B6 Ig kappa chain V-IIIregion HIC Ig kappa chain V-Iregion Ka IGLC1 Ig kappa chain V-Iregion HK101 Ig lambda chain V-IVregion MOL Ig kappa chain V-IIIregion VG Ig lambda chain V-Iregion BL2 Ig kappa chain V-IIIregion SIE Ig kappa chain Vregion EV15 Ig lambda chain V-IIregion MGC Ig kappa chain V-IIIregion NG9 WRC:IRSp53/58:RAC1:GTP:PIP3Ig heavy chain V-IIregion SESS IGLC6 Ig heavy chain V-IIIregion JON Ig heavy chain V-IIIregion TUR Ig heavy chain V-IIIregion LAY Ig lambda chain V-IIregion TOG Ig kappa chain V-Iregion Ka Ig heavy chain V-IIregion COR Ig lambda chain V-VIregion AR Ig lambda chain V-Iregion HA Ig lambda chain V-VIregion AR Ig heavy chain V-IIIregion TRO Ig kappa chain V-IIregion MIL Ig lambda chainV-III region SH Ig kappa chain V-Iregion EU Ig heavy chain V-IIregion HE FCGR1A Ig heavy chain V-Iregion HG3 IgH heavy chainV-III region VH26precursor IGHG1 Ig kappa chain V-IIregion FR Ig lambda chainV-III region LOI Ig kappa chain V-Iregion EU Ig lambda chain V-Iregion NIG-64 Ig kappa chain V-IIregion Cum Ig kappa chain V-Iregion Bi Ig lambda chain V-IVregion MOL IGLV7-43(1-?) IGLV4-60(1-?) Ig kappa chain V-Iregion Hau Ig kappa chain V-IIIregion NG9 ACTR2 Ig heavy chain V-IIIregion WEA Active LIMK1Ig kappa chain V-IIIregion POM Ig kappa chain V-Iregion Gal Ig heavy chain V-IIIregion POM Ig lambda chain V-Vregion DEL Ig heavy chain V-Iregion HG3 SH3 domain proteinsWIPF1 Ig heavy chain V-IIregion OU GTP Ig kappa chain V-IIIregion B6 Ig kappa chain V-IIIregion IARC/BL41 Ig kappa chain V-IIIregion VH IGHV(1-?) Ig kappa chain V-Iregion Rei Ig heavy chain V-IIIregion BUT Ig kappa chain V-IIIregion CLL IGLV1-40(1-?) Ig lambda chain V-IIregion BOH Ig lambda chainV-VII region MOT Ig heavy chain V-IIIregion GAL IGLV2-33(1-?) Ig kappa chain V-IIIregion NG9 IGLV8-61(1-?) IGLC2 Ig kappa chain Vregion EV15 Ig heavy chain V-IIIregion HIL GDP Ig lambda chain V-VIregion SUT Ig heavy chain V-Iregion WOL Ig kappa chain V-Iregion Kue Ig kappa chain V-Iregion Walker Ig kappa chain V-Iregion AG Ig heavy chain V-Iregion SIE Ig heavy chain V-IIIregion NIE Ig lambda chain V-Iregion BL2 SYK Ig kappa chain V-IIregion Cum IGHG1 Ig lambda chain V-Iregion EPS IGLV3-27(1-?) Ig kappa chain V-Iregion CAR Ig kappa chain V-Iregion AU IGLV3-12(1-?) FCGR1A NCK1 Ig kappa chain V-Iregion DEE IGHV7-81(1-?) Ig kappa chain V-IIIregion NG9 Ig heavy chain V-IIIregion JON IGLV3-16(1-?) GRB2-1 Ig heavy chain V-IIregion DAW Ig kappa chain V-Iregion DEE Ig lambda chain V-Iregion EPS Ig kappa chain V-Iregion Gal CDC42 IGHG4 Ig heavy chain V-IIIregion TUR Ig lambda chain V-IIregion TRO Ig kappa chain V-IIIregion VG Ig kappa chain V-Iregion Ni IGLV2-18(1-?) IGLV2-33(1-?) AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramerFCGR1A IGLV1-44(1-?) Ig kappa chain V-Iregion Roy Motherfilament:branchingcomplexIg kappa chain V-IIIregion HAH Ig heavy chain V-IIIregion LAY p-6Y-SYK Ig kappa chain V-Iregion Ni Ig kappa chain V-Iregion Mev CDC42 Ig heavy chain V-IIregion WAH ITPR1 Ig lambda chain V-VIregion NIG-48 IGKV1-5(23-?) ARPC5 IGLC6 Ig heavy chain V-IIIregion NIE Ig heavy chain V-IIregion COR Ig lambda chain V-VIregion SUT Ig heavy chain V-IIIregion HIL Ig kappa chain V-IIregion MIL Ig kappa chain V-Iregion WEA Ig lambda chain V-Iregion VOR Ig kappa chain V-IIIregion VG ATPIg kappa chain V-IIIregion NG9 IGHG3 GTP Ig kappa chain V-Iregion OU Ig kappa chain V-Iregion AG IGLC3 Ig lambda chain V-Vregion DEL Ig heavy chain V-Iregion SIE Ig kappa chain V-IIregion FR IGLV1-44(1-?) p-T,Y MAPK dimersIg heavy chain V-IIregion DAW Ig kappa chain V-IIIregion Ti Ig kappa chain V-IIIregion SIE Ig heavy chain V-IIregion ARH-77 IGLC3 Ig kappa chain V-IVregion Len Ig lambda chain V-IIregion WIN IGLV3-22(1-?) IGLV4-60(1-?) F-actinIGLV3-27(1-?) ATP Ig lambda chain V-IIregion NIG-84 Ig kappa chain V-IIregion GM607 Ig kappa chain V-Iregion BAN Ig kappa chain V-Iregion EU PI(3,4,5)P3Ig heavy chain V-IIIregion GA IGKC ATPIg kappa chain V-Iregion Roy IGLV3-16(1-?) NCKAP1L IGLC2 Ig heavy chain V-Iregion WOL p-S144,T423-PAK1 p-Y256-WASL Ig lambda chain V-IIregion BUR Ig heavy chain V-IIregion COR Ig kappa chain V-IVregion B17 p-Y256-WASL Ig kappa chain V-Iregion AU Ig heavy chain V-IIregion HE Ig lambda chain V-IIregion TOG ARPC1A Ig heavy chain V-IIIregion LAY IGLV4-60(1-?) IGLC2 Ig kappa chain V-Iregion Ni Ig lambda chain V-Iregion VOR Ig lambda chain V-Iregion BL2 Ig kappa chain V-IIIregion POM IGKV1-5(23-?) Ig heavy chain V-IIIregion GAL IGHV7-81(1-?) IGKV4-1(21-?) Ig kappa chain V-Iregion Ni Ig heavy chain V-IIIregion CAM Ig lambda chain V-Iregion VOR Ig kappa chain V-IIIregion IARC/BL41 Ig heavy chain V-IIIregion TRO ACTB(1-375) Ig lambda chain V-Iregion NIG-64 IGLV3-25(1-?) VAV2 IGKVA18(21-?) Ig lambda chain V-VIregion EB4 Ig kappa chain V-IIIregion NG9 Ig heavy chain V-IIIregion TUR Ig kappa chain V-Iregion AU Ig lambda chain V-VIregion AR Ig kappa chain V-Iregion Walker Ig lambda chain V-Iregion HA Ig lambda chain V-VIregion WLT IGLV11-55(1-?) Ig kappa chain V-IIIregion B6 Ig lambda chain V-IIregion NEI Ig heavy chain V-IIIregion JON IGLV2-33(1-?) ELMO2 Ig lambda chain V-IIregion MGC IGKV1-5(23-?) Ig kappa chain V-Iregion Ni Ig lambda chain V-Iregion NIG-64 IGLV11-55(1-?) IGLV4-3(1-?) Ig lambda chain V-Iregion NEW Ig heavy chain V-Iregion HG3 ATPH2OIGLC7 ITPR2 IGHV7-81(1-?) Ig lambda chain V-VIregion WLT WIPF3 Ig heavy chain V-IIIregion TIL Ig lambda chainV-VII region MOT IGLV8-61(1-?) IGLV4-69(1-?) Ig heavy chain V-IIIregion NIE Ig kappa chain V-Iregion AU Ig heavy chain V-IIIregion HIL IGHG1 Ig lambda chain V-IVregion Hil Ig kappa chain V-IIregion GM607 Ig heavy chain V-Iregion SIE Ig kappa chain V-IIregion FR Ig heavy chain V-IIIregion CAM Ig heavy chain V-IIIregion CAM IGLV2-11(1-?) Ig heavy chain V-IIIregion ZAP Ig lambda chain V-IVregion X PI(3,4,5)P3 IGLV10-54(1-?) Ig heavy chain V-IIIregion KOL Ig kappa chain V-Iregion Ka IGLC2 Ig lambda chain V-IVregion Kern Ig kappa chain V-IVregion Len Ig kappa chain V-IIIregion NG9 Ig kappa chain V-IIIregion IARC/BL41 NCKAP1 Ig heavy chain V-Iregion ND IGLV1-40(1-?) Motherfilament:branchingcomplex:daughterfilamentIg lambda chain V-IIregion NIG-84 NCKIPSD IGLV1-40(1-?) clusteredIgG-Ag:p-FCGRsIg lambda chain V-IIregion VIL Ig kappa chain V-IIIregion HIC BAIAP2 PAATP Ig kappa chain V-IIIregion VG IGHG1 Ig heavy chain V-Iregion ND Ig kappa chain V-IVregion Len ATPIg lambda chain V-Iregion NEWM GTP Ig heavy chain V-IIIregion TIL Ig kappa chain V-IVregion B17 IGLV1-40(1-?) Ig heavy chain V-IIregion ARH-77 PI(3,4,5)P3 Ig heavy chain V-IIIregion DOB Ig kappa chain V-Iregion Rei Ig kappa chain V-Iregion Bi IGLV1-40(1-?) IGLV4-60(1-?) Ig heavy chain V-IIIregion NIE VAV3 ARPC3 Ig lambda chain V-Iregion NIG-64 Ig heavy chain V-IIregion MCE Ig lambda chainV-VII region MOT Ig heavy chain V-Iregion WOL ADP IGLV1-44(1-?) IGKV1-5(23-?) RAC1 Ig heavy chain V-IIIregion KOL Ig heavy chain V-Iregion HG3 Ig kappa chain V-IIIregion VH ARPC1A Ig kappa chain V-Iregion Ka Ig kappa chain V-IIIregion GOL Ig lambda chain V-IVregion Kern Ig lambda chain V-IIregion MGC IGKC BAIAP2 IGLV3-12(1-?) Ig heavy chain V-IIregion COR Ig kappa chain V-IIIregion B6 Ig lambda chain V-Iregion BL2 ARPC2 Ig heavy chain V-IIIregion GA IGLV4-60(1-?) Ig kappa chain V-IIregion RPMI 6410 Ig kappa chain V-IIIregion SIE Ig lambda chain V-Iregion BL2 Ig kappa chain V-IVregion STH IGLV(23-?) Ig kappa chain V-Iregion Bi Ig lambda chain V-IIregion VIL Ig kappa chain V-IIregion MIL Ig kappa chain V-IIregion MIL IGLV2-11(1-?) Ig lambda chain V-VIregion NIG-48 IGLV4-69(1-?) IGLV7-43(1-?) IGHV(1-?) Ig kappa chain V-IVregion STH IGLC2 Ig kappa chain V-IIIregion VH Ig kappa chain V-Iregion CAR ATP Ig lambda chainV-VII region MOT Ig lambda chain V-IVregion Hil Ig lambda chainV-III region LOI Ig lambda chain V-IIregion NIG-84 IGLV3-25(1-?) clusteredIgG-Ag:p-FCGRsIg kappa chain V-IIregion GM607 IGHV7-81(1-?) Ig lambda chain V-IIregion NIG-58 IGLV4-69(1-?) Ig kappa chain V-IVregion STH Ig heavy chain V-IIIregion HIL ATPIg kappa chain V-Iregion DEE Ig heavy chain V-IIregion OU Ig kappa chain V-Iregion OU IGLV2-11(1-?) IGLV8-61(1-?) Ig lambda chain V-IVregion Bau Ig heavy chain V-IIIregion POM Ig kappa chain V-IIIregion WOL PI(4,5)P2 Ig heavy chain V-IIIregion WEA IGLV4-69(1-?) Ig lambda chain V-Iregion NIG-64 DAGsIg lambda chain V-IVregion X RAC1 Ig kappa chain V-IVregion STH IGLV5-37(1-?) IGLV4-60(1-?) Ig heavy chain V-IIregion ARH-77 Ig lambda chain V-IIregion NIG-58 Ig lambda chain V-VIregion AR Ig kappa chain V-Iregion WEA Ig lambda chain V-VIregion NIG-48 ATP Ig lambda chain V-IVregion MOL Ig kappa chain V-IIIregion GOL Ig heavy chain V-IIregion SESS Ig lambda chain V-VIregion SUT Ig heavy chain V-IIregion WAH GTP Ig heavy chain V-IIregion MCE IGLV5-37(1-?) Ig heavy chain V-IIIregion TRO Ig heavy chain V-IIIregion NIE Ig kappa chain V-Iregion WAT Ig kappa chain V-Iregion WEA IGLV4-3(1-?) Ig kappa chain V-Iregion Kue Ig lambda chain V-IIregion BUR IGLV5-37(1-?) IGLC1 Ig heavy chain V-IIIregion GA Ig lambda chain Vregion 4A Ig kappa chain V-IIIregion B6 IGHG1 Ig lambda chain V-Vregion DEL Ig lambda chain V-Vregion DEL ADPp-Y256-WASL Ig kappa chain V-IIregion Cum Ig lambda chain V-IIregion BUR Ig kappa chain V-Iregion OU IGLC3 IGLV7-43(1-?) ACTR3 IGLV3-16(1-?) Ig lambda chain V-Iregion NEWM Ig lambda chain V-Vregion DEL Ig kappa chain V-Iregion WEA Ig kappa chain V-IIIregion WOL Ig lambda chain V-Iregion NEWM VAV1,2,3Ig kappa chain V-Iregion Mev Ig lambda chain V-IIregion MGC IGLV4-60(1-?) CYFIP1 Ig lambda chain V-IIregion TRO Ig lambda chain V-IIregion VIL p-Y256-WASL IGHG2 Ig kappa chain V-Iregion Wes Ig lambda chain V-IIregion MGC Ig kappa chain V-IIIregion VG Ig kappa chain V-Iregion BAN Ig heavy chain V-IIIregion TUR ACTB(1-375) Ig kappa chain Vregion EV15 Ig kappa chain V-IIIregion VH Ig heavy chain V-Iregion Mot Ig kappa chain V-Iregion Mev GTP ATPIg kappa chain V-IIregion MIL IGLV5-37(1-?) p-Y160,Y171-CD3G Ig heavy chain V-IIIregion WEA Ig lambda chain Vregion 4A Ig lambda chainV-VII region MOT Ig lambda chain V-VIregion WLT Ig kappa chain V-Iregion Gal ARPC1A Ig kappa chain V-IIIregion HIC NAD+ ADP BAIAP2 MyosinIg kappa chain V-Iregion Daudi IGLV3-25(1-?) Ig kappa chain V-Iregion Ka NCK1 Ig heavy chain V-IIIregion WAS IGLV2-23(1-?) Ig lambda chain V-IIregion NIG-84 GTP Ig heavy chain V-IIIregion LAY Ig lambda chain V-Iregion HA Ig heavy chain V-IIIregion NIE Ig kappa chain V-Iregion BAN Ig lambda chain V-IIregion MGC Ig heavy chain V-IIIregion TRO Ig lambda chainV-III region LOI Ig heavy chain V-Iregion Mot Ig heavy chain V-IIIregion GAL CRKII:DOCK180:ELMOcomplex recruitedto phagocytic cupIg lambda chain V-IVregion X Ig lambda chain V-Iregion NEW IGHG1 Ig kappa chain V-Iregion Scw Ig lambda chain V-VIregion SUT IGLC1 IGHV7-81(1-?) Ig lambda chain V-Iregion NEW p-Y160,Y171-CD3G IGLV2-18(1-?) Ig heavy chain V-Iregion WOL IGLV3-25(1-?) Ig lambda chain V-Iregion WAH Ig heavy chain V-IIregion SESS Ig kappa chain V-IIIregion IARC/BL41 Ig lambda chain V-IVregion X IGHG3 IGLC7 Ig heavy chain V-IIregion WAH NCKAP1L Ig kappa chain V-IIIregion HAH BAIAP2 Ig lambda chainV-VII region MOT Ig lambda chain V-Iregion WAH Ig heavy chain V-IIregion WAH IGKC IGLC6 Ig heavy chain V-IIIregion LAY GTP Ig lambda chain V-IIregion MGC Ig kappa chain V-IIIregion HIC IGKC Ig lambda chain V-IVregion Bau p-6Y-CD247-1 Ig lambda chain V-IIregion TOG IGKV4-1(21-?) Ig lambda chain V-VIregion NIG-48 Ig lambda chain V-IIregion VIL Ig lambda chain V-IIregion WIN IGKV1-5(23-?) Ig lambda chain V-Iregion NIG-64 Ig kappa chain V-IVregion Len Ig kappa chain V-IVregion JI IGLV7-46(1-?) IGLV7-43(1-?) Ig lambda chain V-IIregion NIG-84 Ig lambda chain V-Iregion BL2 PI(3,4)P2Ig lambda chain V-IVregion Kern Ig heavy chain V-Iregion WOL CDC42 Ig lambda chain V-IVregion Hil Ig kappa chain V-Iregion DEE Ig kappa chain V-IIIregion NG9 IGHV(1-?) IGHG3 Ig lambda chain V-Iregion NIG-64 Ig kappa chain V-Iregion OU N-WASP IGLC1 Ig kappa chain V-IIregion MIL Ig kappa chain V-IIregion GM607 Ig lambda chain V-Iregion MEM Ig heavy chain V-IIIregion WAS Ig kappa chain V-IIregion TEW IGHG4 Ig heavy chain V-IIIregion ZAP ATPIGHG2 Ig lambda chain V-Iregion EPS Ig kappa chain V-Iregion Ni Ig heavy chain V-IIIregion POM Ig kappa chain V-Iregion AG IGLV7-46(1-?) Ig lambda chain V-Iregion NEWM PI(4,5)P2Ig heavy chain V-IIIregion GA Ig lambda chain V-IVregion Bau Ig kappa chain V-IIIregion SIE cholineACTR3 IGLC7 Ig heavy chain V-IIIregion DOB Ig heavy chain V-IIIregion JON Ig kappa chain V-IVregion STH Ig heavy chain V-IIIregion GAL p-Y288,Y304-FCGR2A clusteredIgG-Ag:p-FCGRs:p-6Y-SYK:PLCGIGLC2 Ig heavy chain V-IIregion HE Ig heavy chain V-IIIregion NIE Ig lambda chain V-IIregion BOH Ig kappa chain V-Iregion Ka ATPCDC42 Ig lambda chain V-IIregion BO Ig kappa chain V-IIIregion GOL Ig lambda chain V-Iregion BL2 Ig kappa chain V-Iregion WEA IGLV1-44(1-?) Ig kappa chain V-IIregion FR WAS Ig heavy chain V-Iregion HG3 IGLV1-40(1-?) IGLC6 IGLC3 Ig heavy chain V-IIIregion TEI Ig heavy chain V-IIIregion TEI Ig kappa chain V-IIregion TEW Ig kappa chain V-IIIregion WOL IGHG1 ADPIg kappa chain V-Iregion Wes FCGR1A Ig heavy chain V-IIregion ARH-77 WAS Ig lambda chainV-III region LOI IGLV2-23(1-?) Ig heavy chain V-IIIregion ZAP Ig lambda chain Vregion 4A Ig kappa chain V-IVregion STH Ig heavy chain V-IIIregion WEA IGKVA18(21-?) Ig kappa chain V-Iregion AU Ig heavy chain V-IIIregion HIL ACTR3 Ig kappa chain V-Iregion Scw Ig kappa chain V-IIIregion B6 Ig heavy chain V-Iregion Mot Ig lambda chain V-Iregion HA Ig heavy chain V-IIIregion LAY IGLV2-11(1-?) Ig kappa chain V-Iregion BAN Ig heavy chain V-IIIregion LAY ARP2/3 complex (ATPbound)Ig heavy chain V-IIregion ARH-77 Ig lambda chain V-IIregion BOH Ig heavy chain V-Iregion Mot Ig heavy chain V-IIIregion KOL GTP Ig kappa chain V-Iregion Scw IGKVA18(21-?) Ig kappa chain V-Iregion Hau Ig heavy chain V-Iregion ND Ig kappa chain V-IIIregion VH IGLV1-40(1-?) Ig kappa chain V-IIregion Cum IGLV1-40(1-?) Ig kappa chain V-Iregion Daudi Ig lambda chain V-IIregion TRO Ig heavy chain V-IIIregion WEA PI(3,4,5)P3 IGLC2 IGLV1-44(1-?) Ig lambda chain V-VIregion AR Ig heavy chain V-IIIregion BUR ADPIgH heavy chainV-III region VH26precursor Ig heavy chain V-IIIregion BUR Ig kappa chain V-Iregion Lay Ig heavy chain V-IIIregion GAL Ig lambda chain V-Iregion EPS Ig lambda chain V-Iregion NIG-64 IGLV1-44(1-?) HSP90AA1,HSP90AB1IGLV4-3(1-?) Ig lambda chain V-IIregion MGC Ig lambda chain V-VIregion SUT Ig heavy chain V-IIIregion GA Ig lambda chain V-Iregion NEWM IGLV10-54(1-?) Ig lambda chain V-IVregion Bau Ig kappa chain V-IIIregion VH BRK1 Ig heavy chain V-IIIregion BUT Ig kappa chain V-IIregion TEW Ig heavy chain V-IIregion ARH-77 IGHV(1-?) IgH heavy chainV-III region VH26precursor Ig kappa chain V-IVregion B17 IGLV2-18(1-?) Ig heavy chain V-IIIregion LAY Ig lambda chain V-Iregion EPS Ig kappa chain V-IIIregion POM Ig kappa chain V-IIIregion HAH IGLV5-45(1-?) IGLV(23-?) FCGR1A Ig lambda chain V-IIregion NEI Ig kappa chain V-IIIregion WOL Ig kappa chain V-IIIregion WOL Ig lambda chain V-IIregion NIG-58 Ig lambda chain V-IVregion Bau IGLC3 ACTG1 Ig kappa chain V-IIregion RPMI 6410 Ig lambda chainV-VII region MOT Ig kappa chain V-IIIregion GOL Ig kappa chain V-IIIregion IARC/BL41 Ig kappa chain V-Iregion HK101 IGLC1 Ig heavy chain V-IIIregion HIL Ig kappa chain V-Iregion OU IgH heavy chainV-III region VH26precursor NCKAP1L IGLV2-33(1-?) clusteredIgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCGIg lambda chain V-IVregion Hil Ig lambda chain V-IIregion BOH CD3G Ig kappa chain V-Iregion Rei Ig kappa chain V-Iregion DEE Ig lambda chain V-Iregion MEM Ig heavy chain V-IIIregion BRO Ig heavy chain V-IIregion COR Ig kappa chain V-IIIregion NG9 IGLV5-37(1-?) Ig kappa chain V-IIregion Cum IGLV(23-?) Ig heavy chain V-IIIregion BUT Ig lambda chainV-III region LOI Ig kappa chain V-Iregion Wes PI(3,4,5)P3 IGLC6 Ig lambda chain V-Iregion VOR Ig lambda chain V-Iregion EPS IGLV1-36(1-?) Ig kappa chain V-IIregion RPMI 6410 Ig lambda chain V-IVregion Kern IGHG2 BAIAP2 Ig kappa chain V-IIregion RPMI 6410 IGKVA18(21-?) Ig lambda chainV-III region LOI Ig kappa chain V-Iregion Kue Ig heavy chain V-Iregion HG3 WIPF1 Ig heavy chain V-IIIregion TEI IGHG2 Ig heavy chain V-IIIregion NIE p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3Ig lambda chain V-IIregion NIG-58 Ig lambda chain V-IIregion NIG-58 IGLC3 IGLV3-25(1-?) CDC42 Ig heavy chain V-IIIregion BUR Ig kappa chain V-IIIregion SIE IGHV7-81(1-?) Ig lambda chain Vregion 4A ACTR3 Ig lambda chain V-IIregion NIG-84 IGLC7 DAGsIg heavy chain V-IIIregion BRO Ig lambda chain V-Iregion HA Ig heavy chain V-IIIregion BRO Ig kappa chain V-IVregion Len Ig lambda chain V-Iregion HA Ig heavy chain V-IIIregion POM IGLV2-18(1-?) Ig heavy chain V-IIIregion ZAP Ig heavy chain V-IIIregion ZAP VAV1 NCKIPSD DOCK1 Ig kappa chain V-Iregion Rei IGLV1-36(1-?) Ig heavy chain V-IIregion WAH Ig lambda chain V-IIregion BOH Ig kappa chain V-IVregion B17 Ig heavy chain V-Iregion EU IGLV8-61(1-?) clusteredIgG-Ag:FCGRsIg kappa chain V-Iregion CAR GTP Ig kappa chain V-IVregion B17 Ig heavy chain V-IIIregion TIL Ig lambda chain V-IIregion TRO Ig kappa chain V-Iregion WAT Ig heavy chain V-IIIregion POM IGLV1-36(1-?) ARPC3 Ig heavy chain V-IIregion OU Ig kappa chain V-Iregion Gal Ig lambda chain V-VIregion NIG-48 Ig lambda chain V-Iregion WAH IGLV2-23(1-?) IGHG4 Ig heavy chain V-IIIregion BUR Ig lambda chain V-IIregion NEI p-Y160,Y171-CD3G Ig heavy chain V-IIIregion TEI IGLV4-60(1-?) WIPF2 Ig heavy chain V-IIIregion WAS IGHG3 ARPC5 Ig lambda chain V-IIregion TRO Ig kappa chain V-IVregion Len IGLV11-55(1-?) IGLV1-40(1-?) Ig lambda chain V-IVregion X Ig heavy chain V-IIIregion GAL FCGR1A Ig kappa chain V-Iregion Scw Ig kappa chain V-Iregion Mev NCKIPSD Ig heavy chain V-IIIregion KOL Ig heavy chain V-Iregion Mot Ig lambda chain V-Iregion HA GTP FCGR1A Ig kappa chain V-Iregion OU Ig kappa chain V-Iregion Roy IGLC7 IGLV2-18(1-?) IGLV11-55(1-?) Src-kinasesIg kappa chain V-Iregion Mev Ig lambda chain V-Vregion DEL Ig kappa chain V-Iregion WEA Ig kappa chain V-IIregion TEW IGLV10-54(1-?) Ig kappa chain V-IIregion FR Ig lambda chainV-III region LOI Ig heavy chain V-Iregion ND I(1,4,5)P3 Ig lambda chain V-Iregion MEM Ig lambda chainV-III region SH Ig lambda chain V-Iregion EPS IGHG4 PIK3R2 Ig lambda chain V-Iregion NEW IGLV1-40(1-?) p-Y753,Y759,Y1217-PLCG2 IGLV2-11(1-?) BRK1 IGLV11-55(1-?) Ig heavy chain V-Iregion WOL IGHV(1-?) Ig heavy chain V-IIregion SESS Ig kappa chain V-IVregion Len Ig lambda chain V-IVregion Bau Ig lambda chain V-Iregion VOR Ig lambda chain V-IIregion MGC Ig heavy chain V-IIIregion TIL Ig kappa chain V-Iregion Hau Ig kappa chain V-Iregion Daudi Ig kappa chain V-IIregion TEW Ig kappa chain V-IIIregion B6 IGLC7 IGLV7-43(1-?) Ig lambda chain V-Iregion NIG-64 Ig lambda chain V-VIregion SUT IGLV1-40(1-?) Ig kappa chain V-IIIregion B6 IGLV7-46(1-?) Ig lambda chain V-Iregion WAH Ig heavy chain V-IIIregion TEI Ig lambda chain V-VIregion AR Ig kappa chain V-Iregion Roy Ig kappa chain V-IVregion STH ACTG1 Ig kappa chain V-IIIregion CLL Ig lambda chain V-IIregion TOG Ig kappa chain V-Iregion Daudi IGLV11-55(1-?) Ig kappa chain V-IIIregion CLL Ig heavy chain V-IIregion WAH Ig kappa chain V-IIregion FR Ig kappa chain V-Iregion Bi IGHV7-81(1-?) Ig kappa chain V-IIregion RPMI 6410 IGLC7 Ig heavy chain V-Iregion Mot IGLC6 Ig lambda chain V-IVregion Bau Ig lambda chain V-IIregion TOG Ig kappa chain V-Iregion Roy Ig kappa chain V-IIIregion GOL RAC1 IGLV1-36(1-?) Ig lambda chain V-IIregion VIL IGLV4-3(1-?) Ig kappa chain V-IIregion Cum Ig heavy chain V-IIregion NEWM Ig heavy chain V-IIIregion DOB Ig heavy chain V-IIregion NEWM Ig kappa chain V-Iregion Daudi Ig lambda chain V-IIregion TRO Ig heavy chain V-IIregion NEWM Ig kappa chain V-IIregion Cum ARPC2 Ig heavy chain V-IIIregion TRO Ig heavy chain V-IIregion HE p-Y173-VAV3 Ig heavy chain V-IIIregion DOB Ig heavy chain V-Iregion ND Ig kappa chain V-Iregion DEE IGLC7 Ig lambda chainV-III region LOI Ig heavy chain V-Iregion WOL IGKC RAC1:GTPIGHV(1-?) Ig kappa chain V-IIIregion POM IGLV8-61(1-?) Ig kappa chain V-Iregion Bi Ig kappa chain V-Iregion HK101 IGLV3-16(1-?) Ig heavy chain V-IIIregion NIE Ig heavy chain V-IIIregion WEA Ig kappa chain V-Iregion AG ACTB(1-375) Ig lambda chain V-VIregion NIG-48 IGKV1-5(23-?) Ig kappa chain V-Iregion Wes IGLV(23-?) MYO10 Ig lambda chain Vregion 4A Ig kappa chain V-Iregion HK101 Ig lambda chain Vregion 4A WIPF3 ACTB(1-375) Ig lambda chain V-Iregion MEM Ig lambda chain V-VIregion EB4 Ig heavy chain V-IIIregion TUR Ig lambda chain V-IIregion NIG-58 NCKAP1L Ig lambda chain V-VIregion EB4 IGLV1-36(1-?) Ig kappa chain V-IVregion B17 ARPC2 Ig heavy chain V-IIregion NEWM Ig kappa chain V-Iregion DEE Ig lambda chain V-Vregion DEL Ig heavy chain V-IIIregion JON Ig kappa chain V-Iregion Wes IGLV2-33(1-?) Ig kappa chain V-Iregion DEE IGHG2 Ig lambda chain V-VIregion AR Ig kappa chain V-Iregion CAR Ig lambda chain V-VIregion EB4 Ig lambda chain V-IIregion BUR Ig heavy chain V-IIIregion WEA Ig kappa chain V-IIIregion IARC/BL41 Ig heavy chain V-IIregion NEWM GRB2-1 Ig heavy chain V-IIIregion BRO IGHV(1-?) Ig lambda chain V-Iregion NEW clusteredIgG-Ag:p-FCGRs:SYKIGLV7-46(1-?) ACTB(1-375) PIK3CA Ig lambda chain V-IIregion BUR IGHG1 CD247-1 Ig kappa chain V-IIregion RPMI 6410 Ig kappa chain V-IVregion JI IGLV5-37(1-?) IGLV1-44(1-?) Ig heavy chain V-IIregion MCE PCADPPAK1Ig lambda chain V-Iregion BL2 Ig heavy chain V-IIIregion KOL IGLV3-27(1-?) CYFIP1 IGLC2 IGKV4-1(21-?) IGLV2-18(1-?) IGLV2-23(1-?) Ig heavy chain V-IIIregion POM Ig lambda chain V-IIregion BOH Ig heavy chain V-IIIregion CAM Ig heavy chain V-IIIregion CAM Ig kappa chain V-Iregion Scw Ig kappa chain V-IIIregion WOL Ig kappa chain V-Iregion Roy BRK1 IGLV2-18(1-?) Ig heavy chain V-IIregion ARH-77 ACTR2 Ig heavy chain V-IIregion OU WIPF3 Ig lambda chain V-Iregion NIG-64 Ig lambda chain V-IIregion NEI Ig lambda chain V-Iregion MEM Ig lambda chain V-IIregion BUR CRK IGLV3-12(1-?) Ig heavy chain V-IIIregion TUR Ig kappa chain V-Iregion WAT Ig heavy chain V-IIIregion WAS Ig kappa chain V-IIregion Cum Ig kappa chain V-IIIregion CLL Ig kappa chain V-IIIregion POM Ig kappa chain V-IIIregion HAH Ig lambda chain V-IIregion NIG-58 PI3KIg heavy chain V-IIIregion WAS ADP Ig kappa chain V-Iregion AU Ig lambda chain V-VIregion EB4 IGLV2-33(1-?) Ig lambda chainV-III region LOI Ig lambda chainV-III region LOI Ig kappa chain V-IIregion RPMI 6410 PI(3,4,5)P3 Ig kappa chain V-Iregion Kue IGLV7-46(1-?) Ig heavy chain V-IIregion HE Ig heavy chain V-Iregion SIE Ig heavy chain V-IIregion ARH-77 Ig heavy chain V-Iregion HG3 Ig lambda chain V-VIregion WLT Ig heavy chain V-Iregion ND Ig heavy chain V-Iregion WOL IGLV4-60(1-?) Ig heavy chain V-IIIregion HIL Ig kappa chain V-IIIregion HIC IGLV7-46(1-?) ARPC2 CDC42:GTP, RAC1:GTPp-Y160,Y171-CD3G Ig kappa chain V-Iregion Mev Ig lambda chain V-VIregion NIG-48 Ig heavy chain V-IIIregion TRO Ig kappa chain V-IVregion JI Ig heavy chain V-IIIregion BUT PI(4,5)P2 PAK1 dimerIg heavy chain V-Iregion WOL Ig heavy chain V-IIregion COR IGLV4-3(1-?) Ig lambda chain V-IIregion NIG-84 Ig lambda chain V-IIregion NIG-58 IGLV1-36(1-?) Ig kappa chain V-Iregion EU ARPC2 Ig heavy chain V-IIregion DAW Ig kappa chain V-Iregion Daudi Ig lambda chain V-IIregion BOH IGLV3-22(1-?) Ig heavy chain V-IIIregion TEI Ig kappa chain V-IIIregion B6 Ig heavy chain V-Iregion EU Ig lambda chain V-IVregion X Ig heavy chain V-Iregion EU clusteredIgG-Ag:p-FCGRs:p-6Y-SYK:VAVIg kappa chain V-Iregion CAR IGHG2 Ig kappa chain V-Iregion HK101 Ig heavy chain V-IIIregion WAS Ig lambda chain V-IIregion NIG-58 IGLV2-33(1-?) Ig kappa chain V-Iregion CAR FCGRIA:CD3GhomodimerIg lambda chain V-IVregion Kern Ig lambda chain V-VIregion EB4 Ig kappa chain V-Iregion Kue Ig heavy chain V-IIIregion JON IGLV4-69(1-?) Ig lambda chain V-Iregion MEM IGLC6 Ig lambda chain V-Iregion MEM Ig heavy chain V-IIIregion BRO IGLV3-27(1-?) Ig lambda chain V-IIregion NIG-58 Ig heavy chain V-IIIregion GAL Ig kappa chain V-IIIregion IARC/BL41 IGLV3-16(1-?) Ig kappa chain V-IIregion Cum IGKVA18(21-?) Ig kappa chain V-Iregion Scw BRK1 BAIAP2 FCGR1A Ig lambda chainV-III region SH Ig heavy chain V-IIregion OU Ig kappa chain V-Iregion Walker Ig kappa chain V-Iregion Mev Ig kappa chain V-IVregion Len Ig lambda chain V-IVregion Bau IGHV7-81(1-?) IGLV2-11(1-?) Ig lambda chain V-IIregion WIN Ig heavy chain V-Iregion ND Ig kappa chain V-IIIregion Ti Ig heavy chain V-IIIregion TEI p-Y288,Y304-FCGR2A Ig kappa chain V-Iregion Roy Ig heavy chain V-IIIregion CAM IGLV2-11(1-?) Ig kappa chain V-Iregion BAN Ig kappa chain V-Iregion Rei Ig heavy chain V-IIIregion ZAP Ig lambda chain V-IIregion NEI Ig kappa chain V-IIregion RPMI 6410 Ig lambda chain V-IVregion X Ig lambda chain V-IVregion X Ig lambda chain V-IVregion Kern Ig kappa chain V-IIIregion HIC Ig lambda chain V-IIregion VIL Ig kappa chain V-IIIregion Ti NCKIPSD IGLV(23-?) Ig lambda chain V-VIregion AR CRK:DOCK180:ELMO1,ELMO2IGLV2-11(1-?) Ig lambda chain V-VIregion EB4 IGLV2-18(1-?) Ig heavy chain V-IIIregion KOL p-Y160,Y171-CD3G Ig lambda chain V-Vregion DEL Ig lambda chain V-Iregion EPS Ig kappa chain V-Iregion HK101 Ig heavy chain V-IIregion NEWM Ig kappa chain V-IVregion STH Ig kappa chain V-Iregion OU IGLV4-69(1-?) IGLV3-22(1-?) Ig kappa chain V-IVregion Len Ig lambda chainV-VII region MOT Ig heavy chain V-IIIregion ZAP Ig lambda chainV-III region SH IGLC3 Ig kappa chain V-IIIregion GOL Ig heavy chain V-IIIregion ZAP Ig heavy chain V-Iregion EU ARPC5 Ig kappa chain V-Iregion AU Ig heavy chain V-IIIregion JON Ig kappa chain V-Iregion Walker GRB2-1 Ig heavy chain V-IIIregion WEA Ig lambda chain V-VIregion WLT IGLV3-12(1-?) ADPFCGR1A Ig kappa chain V-IIregion MIL Ig kappa chain V-IVregion JI Ig kappa chain V-IIIregion GOL Ig kappa chain V-Iregion HK101 Ig kappa chain V-Iregion HK101 Ig kappa chain V-IIregion RPMI 6410 Ig kappa chain V-IIregion TEW Ig kappa chain V-Iregion AG p-Y160,Y171-CD3G FCGR3A Ig heavy chain V-IIIregion BRO Ig heavy chain V-IIregion HE GTP Ig kappa chain V-Iregion Walker IGLV11-55(1-?) IGLC6 Ig heavy chain V-IIIregion HIL Ig lambda chain V-IIregion BO IGLC2 Ig lambda chain V-Iregion NEW IGKV4-1(21-?) Ig heavy chain V-IIIregion BUT ARPC1A Ig kappa chain V-Iregion Gal Ig lambda chain V-IIregion TRO Ig heavy chain V-IIIregion DOB ITPR2 Ig kappa chain Vregion EV15 Ig kappa chain V-IIIregion IARC/BL41 IGKVA18(21-?) BRK1 Ig lambda chainV-VII region MOT WIPF1 Ig kappa chain V-IIIregion SIE IGLV3-25(1-?) Ig lambda chain V-IIregion TOG GRB2-1 ARPC5 Ig kappa chain V-Iregion Scw Ig heavy chain V-Iregion SIE Ig heavy chain V-IIIregion BUR Ig heavy chain V-IIIregion TIL IGLV4-69(1-?) Ig lambda chain V-IVregion Kern Ig kappa chain V-Iregion Roy IGHG4 Ig heavy chain V-IIregion WAH Ig kappa chain V-IIregion MIL IGLV3-27(1-?) Ig lambda chain V-IVregion Hil IgH heavy chainV-III region VH26precursor Ig lambda chain V-IVregion MOL IGHV7-81(1-?) Ig kappa chain V-IIIregion NG9 IGLV4-3(1-?) NCKAP1 Ig heavy chain V-IIIregion TIL Ig heavy chain V-IIIregion POM Ig kappa chain V-Iregion Scw Ig heavy chain V-Iregion ND Ig kappa chain V-Iregion EU Ig lambda chain V-IVregion X Ig kappa chain V-IIIregion POM IGHV7-81(1-?) IGHV(1-?) FCGR3A IGLC6 Ig heavy chain V-IIIregion BRO Ig kappa chain V-Iregion Rei Ig heavy chain V-IIIregion GAL IGLV5-37(1-?) Ig lambda chain V-VIregion NIG-48 Ig kappa chain V-Iregion Gal NCK1 IGLV4-69(1-?) Ig lambda chain V-IIregion VIL Ig kappa chain V-Iregion Mev Ig lambda chain V-IIregion WIN IGLC6 Ig heavy chain V-IIIregion NIE IGLV10-54(1-?) IGKVA18(21-?) Ig kappa chain V-Iregion Gal Ig lambda chain V-VIregion SUT IGHG3 ATPIg lambda chain V-VIregion AR IGLV1-40(1-?) ARPC3 ADP IGLV1-44(1-?) Ig lambda chain V-VIregion AR IGLC1 BAIAP2 H2OCYFIP2 Ig heavy chain V-IIIregion BRO Ig lambda chain V-Iregion MEM Ig kappa chain V-IIIregion VH IgH heavy chainV-III region VH26precursor IGLV11-55(1-?) Ig lambda chain V-Iregion WAH ACTG1 Ig kappa chain V-Iregion CAR IGHG2 Ig lambda chain Vregion 4A Ig kappa chain V-Iregion Ka Ig lambda chain V-IVregion Kern Ig heavy chain V-IIIregion KOL Ig heavy chain V-IIregion MCE IGLV3-12(1-?) Ig heavy chain V-IIIregion GA IGHV7-81(1-?) Ig lambda chain Vregion 4A Ig lambda chain V-VIregion EB4 Ig heavy chain V-IIIregion WAS Ig heavy chain V-IIIregion POM Ig lambda chain V-Iregion WAH Ig kappa chain V-IIIregion WOL CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteinsIg heavy chain V-IIIregion WAS PLDIg lambda chain V-VIregion SUT IGLV11-55(1-?) CDC42:GTP:WASP/N-WASP:WIP:SH3 proteinsWIPF2 p-6Y-SYK Ig heavy chain V-IIregion NEWM IGHG4 Ig heavy chain V-IIregion DAW IGLV5-37(1-?) p-6Y-SYK Ig heavy chain V-Iregion ND Ig heavy chain V-IIIregion GA Ig heavy chain V-IIregion ARH-77 Ig kappa chain V-Iregion Lay Ig lambda chain V-VIregion EB4 Ig lambda chain V-IIregion BUR Ig heavy chain V-IIregion HE Ig kappa chain V-IVregion JI IGLV3-12(1-?) IGLV7-46(1-?) Ig kappa chain V-IIIregion POM ADPIg kappa chain V-Iregion Kue p-Y172-VAV2 NCKAP1 Ig kappa chain V-IIIregion GOL Ig heavy chain V-IIIregion BUT ARPC4 Ig heavy chain V-IIIregion WEA Ig lambda chain V-IIregion BO Ig kappa chain V-IIIregion IARC/BL41 Ig heavy chain V-IIIregion GAL IGHV7-81(1-?) IGKC IGLV7-46(1-?) Ig lambda chain V-IIregion TOG Ig kappa chain V-IIIregion Ti IGHG4 Ig heavy chain V-IIIregion CAM Ig lambda chain V-IVregion Hil Ig lambda chain V-VIregion WLT IGLV3-16(1-?) IGKC Ig kappa chain V-IVregion B17 BRK1 Ig lambda chain V-IIregion TOG IGLV2-33(1-?) CFL1NCK1 Ig kappa chain V-Iregion Walker IGLV8-61(1-?) IGLV5-37(1-?) Ig heavy chain V-IIregion MCE Ig kappa chain V-Iregion OU ACTR3 Ig heavy chain V-IIIregion DOB Ig heavy chain V-IIregion COR Ig heavy chain V-Iregion EU IGLV2-33(1-?) NCKIPSD NCKAP1 Ig heavy chain V-IIregion SESS IGLC1 IGLV3-27(1-?) Ig lambda chain V-IIregion BUR Ig lambda chain V-IIregion BO Ig kappa chain V-Iregion Ni Ig kappa chain V-Iregion Rei Ig lambda chain V-IVregion Kern Ig kappa chain V-Iregion WEA IGLV10-54(1-?) Ig heavy chain V-IIIregion HIL Ig kappa chain Vregion EV15 IGLV5-45(1-?) Ig heavy chain V-IIIregion WAS Ig kappa chain V-IVregion Len Ig heavy chain V-IIregion MCE Ig lambda chain V-IVregion Hil Ig heavy chain V-IIIregion POM ACTB(1-375) Ig kappa chain V-Iregion Rei Ig kappa chain V-Iregion AG CYFIP1 H2OIg lambda chain V-IIregion TRO p-6Y-CD247-1 Ig kappa chain V-Iregion Bi Ig kappa chain V-Iregion EU Ig lambda chain V-Iregion HA BAIAP2 Ig kappa chain V-Iregion Roy Ig lambda chain V-VIregion AR IGLV4-3(1-?) Ig kappa chain V-Iregion Wes Ig heavy chain V-IIIregion BUR Ig lambda chain V-Iregion NEWM Ig lambda chain V-Iregion NEW Ig heavy chain V-IIregion SESS Ig heavy chain V-IIregion SESS Ig lambda chain V-Iregion NEWM IGLV3-22(1-?) Ig lambda chain V-IIregion BOH Ig kappa chain V-IIIregion VG Ig kappa chain V-IIIregion SIE Ig lambda chain V-IIregion WIN Ig kappa chain V-Iregion Walker Ig heavy chain V-IIregion COR Ig lambda chain V-IIregion TOG Ig heavy chain V-IIIregion LAY Ig heavy chain V-IIregion ARH-77 Ig heavy chain V-IIregion OU IGLV3-27(1-?) PLA2G6Ig lambda chain V-IIregion MGC PI(4,5)P2 p-S144,T423-PAK1IGLV5-37(1-?) Ig heavy chain V-Iregion Mot Ig kappa chain V-Iregion Mev PI(3,4,5)P3 IGLC1 Ig lambda chain V-Iregion NEWM Ig kappa chain V-Iregion WEA IGHV(1-?) Ig heavy chain V-IIregion MCE Ig lambda chain V-IIregion TRO PI(4,5)P2 Ig kappa chain V-Iregion Kue Ig kappa chain V-Iregion Rei Ig heavy chain V-IIregion OU Ig lambda chain V-Vregion DEL Ig heavy chain V-IIIregion GAL Ig kappa chain V-IVregion JI Ig lambda chain Vregion 4A Ig lambda chain V-IIregion NIG-58 Ig kappa chain V-IVregion Len Phospho-PKC-delta/epsilonIg lambda chain V-IIregion NEI Ig kappa chain V-IIIregion SIE CYFIP1 Ig kappa chain V-IIregion GM607 PAK1 ACTG1 Ig lambda chain V-IVregion MOL p-6Y-CD247-1 ACTR2 Ig heavy chain V-IIIregion BRO GTPFCGR3A Ig kappa chain V-IIIregion HAH Ig lambda chain V-Iregion VOR Ig kappa chain V-Iregion WAT Ig lambda chain V-VIregion NIG-48 Ig kappa chain V-Iregion AG IGHG3 IGHG2 IGLC1 Ig kappa chain V-Iregion Walker Ig lambda chain V-IIregion BUR IgH heavy chainV-III region VH26precursor Ig lambda chain V-VIregion WLT ITPR3 IGHG4 Ig heavy chain V-IIIregion TIL Ig kappa chain V-IIIregion HIC Ig kappa chain V-IIIregion VG Ig heavy chain V-IIIregion GA Ig kappa chain V-Iregion Hau GTP Ig heavy chain V-IIIregion CAM IGLV3-16(1-?) Ig lambda chain V-IIregion BOH Ig lambda chain V-IIregion TOG IGLV8-61(1-?) ADPIg heavy chain V-IIIregion GA Ig heavy chain V-IIIregion DOB Ig heavy chain V-IIIregion BUT Ig lambda chain V-IVregion Kern DOCK1 Ig heavy chain V-IIIregion GA Ig heavy chain V-IIIregion JON Ig kappa chain V-Iregion Ka GRB2-1 Ig kappa chain V-IVregion JI Actin:ADPp-Y291-WAS Ig kappa chain V-IIregion GM607 Ig kappa chain V-IIIregion VG ATP Ig kappa chain V-IIIregion HIC Ig heavy chain V-IIIregion KOL Ig lambda chain V-Iregion BL2 IGLV3-27(1-?) Ig heavy chain V-IIregion MCE Ig kappa chain V-IVregion Len IGLV(23-?) Ig kappa chain V-IIregion MIL Ig kappa chain V-Iregion AU Ig heavy chain V-IIIregion WEA IGKV1-5(23-?) PiIGLC2 Ig kappa chain V-Iregion WAT Ig kappa chain V-Iregion BAN IGLC7 IGLC6 IGLV2-11(1-?) Ig kappa chain V-IIIregion WOL IGLV7-46(1-?) Ig lambda chain V-IVregion X CD3G Ig heavy chain V-IIIregion BUR Ig heavy chain V-IIregion COR Ig kappa chain V-IIIregion VH Ig lambda chain V-IIregion NIG-58 PiIg lambda chain V-IIregion NEI Ig heavy chain V-IIIregion BRO Ig lambda chain V-IIregion TRO Ig kappa chain V-IIIregion B6 Ig lambda chain V-IIregion NIG-58 IGLV8-61(1-?) BRK1 Ig kappa chain V-Iregion AG IGLC1 IGLV2-18(1-?) Ig kappa chain V-Iregion Lay Ig heavy chain V-Iregion WOL Ig heavy chain V-IIIregion BRO Ig kappa chain Vregion EV15 Ig lambda chain V-Iregion EPS Ig lambda chain V-Iregion WAH Ig kappa chain V-Iregion Ni Ig kappa chain V-Iregion Gal IGHG3 Ig lambda chain V-IIregion NEI Ig lambda chain V-IIregion TOG clusteredIgG-Ag:p-FCGRs:p-6Y-SYK:p-VAVIGLV7-43(1-?) Ig kappa chain V-IIIregion HAH Ig kappa chain V-IIIregion CLL IGKV1-5(23-?) IGLV3-12(1-?) Ig lambda chain V-Iregion HA Ig lambda chain V-Iregion BL2 Ig kappa chain V-IIIregion VG Ig lambda chain V-VIregion NIG-48 Ig heavy chain V-Iregion HG3 Ig kappa chain V-IIIregion HAH Ig heavy chain V-IIregion DAW IGLC3 Ig heavy chain V-IIIregion GA Ig lambda chain V-IVregion Bau Ig heavy chain V-Iregion SIE Ig heavy chain V-IIIregion TEI IGLV1-36(1-?) p-Y288,Y304-FCGR2A Ig kappa chain V-Iregion Bi Ig lambda chain V-IIregion NIG-84 Ig kappa chain V-IIIregion Ti Ig lambda chain V-Iregion WAH clusteredIgG-Ag:p-FCGRsIg kappa chain V-IVregion Len Ig lambda chain Vregion 4A Ig heavy chain V-IIIregion DOB IGLV3-12(1-?) GDP Ig kappa chain Vregion EV15 Ig heavy chain V-IIregion MCE Ig kappa chain V-IIIregion VH Ig heavy chain V-IIIregion BUT IGLV5-37(1-?) Ig kappa chain V-Iregion AG Ig kappa chain V-IIIregion HIC IGLV5-45(1-?) IGLV1-44(1-?) Ig kappa chain V-Iregion Roy p-Y291-WAS IgH heavy chainV-III region VH26precursor WIPF1 IGKV1-5(23-?) Ig heavy chain V-IIIregion HIL Ig kappa chain V-IVregion B17 IGHV7-81(1-?) Ig lambda chain V-Iregion NEWM IGKV1-5(23-?) Ig heavy chain V-IIregion WAH Ig lambda chain V-IVregion MOL Ig kappa chain V-IIIregion IARC/BL41 Ig kappa chain V-IIregion FR Ig kappa chain V-Iregion AG Ig heavy chain V-IIIregion BRO IGLV(23-?) Ig kappa chain V-IIIregion Ti Ig kappa chain V-Iregion Ka ELMO1 p-6Y-SYK IGLV10-54(1-?) IGHG3 Ig heavy chain V-IIIregion ZAP IGLV2-18(1-?) Ig kappa chain V-Iregion AG Ig kappa chain V-Iregion EU IGLV4-60(1-?) Ig kappa chain V-IIIregion GOL IGLV10-54(1-?) CD247-1 IGHG4 IGLV3-27(1-?) Ig kappa chain V-IIIregion HAH p-T508-LIMK1IGKC Ig heavy chain V-IIIregion POM Ig lambda chain V-IVregion Hil IgH heavy chainV-III region VH26precursor ATP Ig lambda chain V-VIregion NIG-48 Ig kappa chain V-Iregion WEA Ig kappa chain Vregion EV15 Ig kappa chain V-Iregion Mev Ig heavy chain V-IIregion ARH-77 Ig heavy chain V-IIIregion TEI Ig heavy chain V-IIregion SESS IGLC3 Ig lambda chain V-VIregion WLT Ig kappa chain V-Iregion OU IGLV8-61(1-?) Ig heavy chain V-IIIregion TRO Ig kappa chain V-Iregion CAR Ig lambda chain V-IIregion NEI IGHG1 Ig heavy chain V-Iregion SIE Ig lambda chain V-VIregion EB4 Ig kappa chain V-Iregion DEE FCGR3A H2OIg heavy chain V-IIIregion TUR Ig kappa chain V-IIregion Cum Ig lambda chain V-IVregion MOL ATPIg kappa chain V-Iregion Ka Ig heavy chain V-IIIregion TEI p-Y256-WASL Ig lambda chain V-Iregion BL2 PI(3,4,5)P3Ig kappa chain V-Iregion Kue Ig kappa chain V-Iregion BAN Ig heavy chain V-IIIregion GA p-S,T508-LIMK1 IGLV5-45(1-?) PhosphatidatephosphataseIg kappa chain V-Iregion Scw Ig heavy chain V-IIIregion CAM Ig heavy chain V-IIregion DAW Ig kappa chain V-Iregion Lay Ig heavy chain V-IIregion WAH Ig kappa chain V-Iregion Hau Ig kappa chain V-IIIregion B6 Ig lambda chain V-Iregion NIG-64 Ig kappa chain V-Iregion Ni Ig kappa chain V-Iregion Walker FCGR1A Ig kappa chain V-Iregion Hau Ig heavy chain V-Iregion HG3 IGLC1 Ig kappa chain V-Iregion OU IgH heavy chainV-III region VH26precursor Ig kappa chain V-Iregion EU Ig lambda chain V-IVregion Bau Ig heavy chain V-IIregion SESS Ig kappa chain V-IIIregion CLL IGLV7-43(1-?) Activated WAVE2 andWASP/N-WASPIg lambda chain V-IIregion BOH Ig kappa chain V-IIIregion IARC/BL41 Ig kappa chain V-IVregion JI GTPIg kappa chain V-IIregion TEW Ig kappa chain V-Iregion EU IGKV4-1(21-?) Ig kappa chain V-Iregion WEA IGKC Ig kappa chain V-Iregion Hau IGLV8-61(1-?) Ig heavy chain V-IIregion WAH Ig lambda chain V-IVregion X IGLV2-11(1-?) Ig kappa chain V-Iregion DEE IGLV10-54(1-?) Ig lambda chain V-Iregion HA Ig lambda chain V-IVregion Bau Ig heavy chain V-IIIregion TRO Ig kappa chain V-IIIregion NG9 Ig heavy chain V-IIregion DAW Ig lambda chain V-IIregion TRO Ig heavy chain V-IIIregion BUR Ig lambda chain V-IVregion X Ig lambda chain V-VIregion SUT Ig lambda chain Vregion 4A Ig lambda chain V-Iregion BL2 Ig heavy chain V-IIregion HE Ig kappa chain V-Iregion Daudi Ig kappa chain V-IVregion STH IGHG1 Ig kappa chain V-IIIregion NG9 Ig kappa chain V-Iregion EU Ig lambda chain V-Vregion DEL Ig lambda chain V-IIregion TRO IGLV2-11(1-?) IGLV5-37(1-?) IGLV1-40(1-?) Ig heavy chain V-IIIregion WAS p-6Y-CD247-1 RAC1 IGLV4-3(1-?) Ig heavy chain V-IIIregion WEA Ig kappa chain V-Iregion Daudi Ig kappa chain V-IIIregion Ti Ig lambda chain V-Vregion DEL WIPF2 Ig kappa chain V-Iregion Ni Ig heavy chain V-Iregion WOL Ig kappa chain V-Iregion BAN ARPC4 Ig lambda chain V-Iregion NIG-64 Ig lambda chain V-VIregion WLT Ig kappa chain V-IIIregion CLL p-Y291-WAS Ig lambda chain V-IIregion VIL Ig kappa chain V-IIregion Cum ADPIg kappa chain V-Iregion Kue Ig kappa chain V-IVregion Len IgH heavy chainV-III region VH26precursor CDC42:GTPIg kappa chain V-Iregion Hau IGLV4-69(1-?) Ig lambda chain V-Vregion DEL IGLV3-12(1-?) Ig heavy chain V-IIregion ARH-77 Ig heavy chain V-IIregion SESS CD3G Ig kappa chain V-IIIregion VH Ig kappa chain V-IIIregion VG Ig kappa chain V-Iregion WEA Ig lambda chainV-III region LOI Ig heavy chain V-IIIregion WAS IGLC1 Myosin-X dimerWIPF2 WIPF1 ADPIg heavy chain V-IIIregion BRO Ig lambda chain V-Iregion VOR Ig kappa chain V-Iregion CAR Ig lambda chain V-IIregion VIL Ig kappa chain V-Iregion Lay Ig kappa chain V-IIregion MIL IGLV5-45(1-?) Ig heavy chain V-IIIregion TRO IGLV8-61(1-?) IgG-Ag:FCGRIIAIGLV5-45(1-?) Ig heavy chain V-IIregion HE Ig lambda chainV-III region SH Ig heavy chain V-IIIregion TRO Ig heavy chain V-IIIregion TEI RAC1 Ig heavy chain V-IIIregion ZAP IGKV4-1(21-?) Ig lambda chain V-IIregion BOH IGLV5-45(1-?) ARPC1A Ig lambda chain V-IIregion WIN 2-LysophosphatidylcholineIg lambda chain V-Iregion WAH IGLV(23-?) IGLV4-3(1-?) Ig kappa chain V-IIIregion HIC Ig lambda chain V-VIregion WLT p-S,T508-LIMK1 Ig heavy chain V-IIIregion BUR Ig lambda chain Vregion 4A IGLV3-27(1-?) Ig kappa chain V-Iregion Mev ACTB(1-375) Ig heavy chain V-IIIregion DOB PiIg kappa chain V-Iregion HK101 IGLC6 IGLV5-45(1-?) Ig kappa chain V-Iregion WAT Ig kappa chain V-Iregion Rei IGHV(1-?) Ig lambda chain V-IIregion BUR Ig lambda chainV-III region LOI Ig kappa chain V-Iregion DEE Ig heavy chain V-IIIregion TRO IGLV8-61(1-?) Ig heavy chain V-IIIregion BUT Ig heavy chain V-IIIregion LAY Ig kappa chain V-Iregion AG GTP IGHG3 Ig kappa chain V-IIregion TEW Ig heavy chain V-IIIregion CAM Ig heavy chain V-IIIregion ZAP Ig kappa chain V-Iregion Gal Ig kappa chain V-IIregion GM607 Ig heavy chain V-Iregion Mot NCK1 Ig kappa chain V-IIIregion B6 Ig lambda chain V-IVregion MOL p-Y288,Y304-FCGR2A IGLV5-45(1-?) Ig kappa chain V-IVregion STH Ig kappa chain V-Iregion Lay Ig heavy chain V-IIIregion TUR IGLV2-11(1-?) Ig kappa chain V-Iregion EU Ig lambda chain V-IIregion TOG Ig kappa chain V-Iregion Wes Ig kappa chain V-Iregion HK101 IGLV3-22(1-?) Ig heavy chain V-IIIregion TUR Ig kappa chain V-Iregion AU Ig heavy chain V-IIIregion GAL Ig heavy chain V-IIIregion TIL Ig lambda chain V-IVregion MOL Ig heavy chain V-IIIregion BUT Ig heavy chain V-Iregion SIE ARPC5 Ig lambda chain V-VIregion EB4 IGLV2-18(1-?) IGLV3-25(1-?) IGLV7-46(1-?) IGLV3-22(1-?) Ig heavy chain V-IIIregion WEA Ig heavy chain V-Iregion Mot ATP Ig lambda chain V-IVregion X Ig kappa chain Vregion EV15 BRK1 Ig heavy chain V-IIregion COR ATPp-Y288,Y304-FCGR2A Ig kappa chain V-Iregion WAT IGLV3-22(1-?) Ig heavy chain V-IIregion WAH Ig heavy chain V-IIIregion HIL CDC42 IGLV4-60(1-?) ATPIGLV3-16(1-?) IGLV8-61(1-?) Ig kappa chain V-IIregion RPMI 6410 Ig kappa chain V-Iregion Scw PhosphatidylcholineIg heavy chain V-IIregion WAH Ig heavy chain V-IIregion COR CYFIP2 WIPF2 Ig heavy chain V-IIregion NEWM Ig kappa chain V-IIIregion POM Ig kappa chain V-IIregion FR Ig kappa chain V-Iregion AG LIMK1IGHG4 GTP Ig lambda chain V-IIregion NEI Ig kappa chain V-Iregion Wes Ig lambda chainV-III region LOI Ig heavy chain V-IIregion SESS PI(3,4,5)P3 IGLV3-12(1-?) Ig lambda chain V-Vregion DEL Ig lambda chainV-VII region MOT IGLV3-16(1-?) Ig heavy chain V-Iregion Mot Ig kappa chain V-Iregion WAT IGLC2 Ig lambda chain V-Iregion NEW Ig kappa chain V-Iregion Roy Ig lambda chain V-Iregion EPS Ig heavy chain V-IIregion MCE Ig heavy chain V-IIIregion KOL Ig kappa chain V-IIIregion VH Ig heavy chain V-Iregion EU Ig kappa chain V-Iregion Ka Ig kappa chain V-IIIregion WOL Ig kappa chain V-Iregion Kue Ig heavy chain V-IIregion OU Ig heavy chain V-IIIregion GAL Ig lambda chain V-IIregion MGC IGLV7-43(1-?) IGLV11-55(1-?) Ig kappa chain V-Iregion Wes CDC42 Ig heavy chain V-IIregion SESS Ig kappa chain V-IIregion FR Ig lambda chain V-IIregion TOG IGLC3 NCKAP1 ATPIg kappa chain V-Iregion HK101 IGLV4-69(1-?) Ig kappa chain V-IIIregion SIE Ig kappa chain V-Iregion Lay Ig heavy chain V-IIIregion TUR Ig lambda chainV-III region SH Ig heavy chain V-Iregion Mot Ig kappa chain V-IIregion GM607 Ig kappa chain V-Iregion Bi Ig kappa chain V-Iregion Mev Ig heavy chain V-IIIregion ZAP Ig heavy chain V-IIIregion TIL Ig heavy chain V-Iregion HG3 Ig lambda chain V-IIregion NIG-84 Ig kappa chain V-IIIregion GOL IGLC1 IGHG3 Ig kappa chain V-IIregion MIL Ig lambda chain V-Iregion WAH IGHG2 Ig kappa chain V-IIregion Cum Ig lambda chain V-IIregion BO ADPIg lambda chain V-IIregion BOH Ig kappa chain V-IIregion GM607 IGLC7 GDPp-4Y-PLCG1Ig kappa chain V-Iregion Roy IGLV10-54(1-?) IGLV3-12(1-?) Ig heavy chain V-IIregion NEWM Ig kappa chain V-Iregion WAT Ig kappa chain V-IIIregion HAH ARPC3 Ig lambda chain V-Iregion MEM IGKV1-5(23-?) Ig heavy chain V-IIIregion POM WIP family proteinsIg kappa chain V-IIIregion VH IgG-Ag:FCGRIA:CD3GhomodimerIg lambda chain V-VIregion NIG-48 Ig kappa chain V-IVregion STH Ig kappa chain V-IIIregion NG9 Ig heavy chain V-IIregion ARH-77 IGLV7-43(1-?) Ig lambda chain V-Iregion MEM Ig kappa chain V-Iregion Kue IGKV1-5(23-?) Ig kappa chain V-Iregion Gal Ig kappa chain V-IVregion STH Ig lambda chain V-IIregion VIL Ig heavy chain V-IIregion NEWM Ig heavy chain V-IIIregion BUR Ig kappa chain V-IIregion Cum Ig lambda chain Vregion 4A Ig heavy chain V-IIIregion BRO CYFIP1 pCofilin: ActiveLIMK-1Ig kappa chain V-Iregion Mev Ig kappa chain V-IIIregion CLL Ig heavy chain V-IIIregion GA Ig kappa chain V-Iregion Kue Ig lambda chain V-VIregion WLT PIK3CA Ig lambda chain V-Iregion HA IGHG3 IGLV(23-?) Ig kappa chain V-Iregion BAN WIPF3 NCKAP1 Ig kappa chain V-Iregion OU IGHG4 Ig kappa chain V-IIIregion CLL Ig kappa chain V-Iregion Wes Ig kappa chain V-IIIregion NG9 IGLV3-25(1-?) Ig heavy chain V-Iregion ND Ig heavy chain V-IIIregion WEA Ig heavy chain V-IIIregion KOL IGLV3-22(1-?) Ig lambda chain V-IIregion WIN IGHG2 Ig heavy chain V-Iregion HG3 Ig kappa chain V-Iregion Walker Ig kappa chain V-IIIregion IARC/BL41 CD3G IGLV(23-?) Ig kappa chain V-Iregion CAR Ig heavy chain V-Iregion Mot CDC42 Ig lambda chain V-Iregion MEM IGLV8-61(1-?) Ig kappa chain V-Iregion Walker Ig heavy chain V-IIIregion BUT IGLV1-36(1-?) Ig heavy chain V-IIregion OU PI(4,5)P2 Ig kappa chain V-IIregion TEW HSP90AA1 Ig lambda chain V-IIregion BO Ig lambda chain V-VIregion SUT IGHV(1-?) Ig kappa chain V-Iregion Ka Ig kappa chain V-Iregion Ni Ig heavy chain V-Iregion EU IGLC3 Ig kappa chain V-Iregion HK101 Ig kappa chain V-IIregion RPMI 6410 Ig lambda chain V-IVregion Bau Ig lambda chain V-IIregion NEI Ig lambda chain V-Iregion VOR Ig heavy chain V-IIIregion WAS Ig heavy chain V-Iregion EU p-Y160,Y171-CD3G IGLC3 IGLV4-69(1-?) PAK1 Ig heavy chain V-IIIregion JON Ig kappa chain V-Iregion Daudi Ig kappa chain V-IIIregion HIC Ig lambda chain V-IVregion X NCKAP1L FCGR3A Ig kappa chain V-IVregion B17 Ig lambda chain V-IVregion Kern Ig lambda chain V-Iregion HA Ig lambda chain V-IVregion Hil IGLV2-23(1-?) Ig kappa chain V-Iregion Scw Ig heavy chain V-IIregion HE IGLV1-44(1-?) Ig kappa chain V-Iregion AG Ig lambda chain V-VIregion WLT p-Y160,Y171-CD3G IGLV4-3(1-?) IGLC3 Ig lambda chain V-VIregion AR Ig kappa chain V-IIIregion HIC Ig kappa chain V-Iregion Rei ITPR:I(1,4,5)P3tetramerIg lambda chain V-IVregion MOL Ig lambda chain V-IIregion MGC Ig lambda chain V-Iregion NIG-64 Ig lambda chain V-IIregion NEI Ig heavy chain V-IIIregion WEA Ig heavy chain V-IIIregion GAL Ig kappa chain V-IIregion RPMI 6410 Ig kappa chain V-IIIregion SIE IGLV3-25(1-?) ARPC1A Ig kappa chain V-Iregion AU Ig heavy chain V-IIIregion NIE G-actinIg lambda chain V-Iregion NEW IGLV3-22(1-?) Ig lambda chain V-VIregion SUT Ig lambda chain V-Iregion WAH Ig lambda chain V-IIregion BO PI(4,5)P2 Ig kappa chain V-Iregion Scw IGLV7-43(1-?) IGLV2-23(1-?) Ig lambda chain V-IIregion BUR IGLV2-23(1-?) Ig kappa chain V-IIIregion GOL IGHG4 Ig kappa chain V-Iregion BAN Ig lambda chain V-IIregion NIG-84 Ig kappa chain V-Iregion Scw IGLV2-33(1-?) Actin filament boundMyosin-XIg heavy chain V-IIregion NEWM Ig kappa chain V-Iregion Lay IGLV3-22(1-?) Ig heavy chain V-IIIregion BUR ATPIg kappa chain V-IIregion FR IGLV1-40(1-?) Ig kappa chain V-Iregion AG ADPIg kappa chain V-Iregion OU Ig lambda chain V-Iregion MEM Ig kappa chain V-Iregion WEA Ig kappa chain V-IIIregion POM Ig heavy chain V-IIregion WAH Ig lambda chain V-VIregion AR Ig lambda chain V-IIregion TRO Ig lambda chain V-IIregion WIN Ig kappa chain V-IIregion MIL IGLV4-60(1-?) IGLV2-11(1-?) IGLV3-16(1-?) Ig lambda chain V-IIregion NEI p-6Y-CD247-1 Ig heavy chain V-IIIregion TUR Ig kappa chain V-Iregion Bi Ig kappa chain V-IIregion Cum Ig kappa chain V-IIIregion VG IGLC6 IgH heavy chainV-III region VH26precursor IGLV3-22(1-?) IGLC2 ARPC3 Ig heavy chain V-IIregion DAW Ig heavy chain V-Iregion SIE 17, 351791


Description

Phagocytosis is one of the important innate immune responses that function to eliminate invading infectious agents. Monocytes, macrophages, and neutrophils are the professional phagocytic cells. Phagocytosis is a complex process involving the recognition of invading foreign particles by specific types of phagocytic receptors and the subsequent internalization of the particles. Fc gamma receptors (FCGRs) are among the best studied phagocytic receptors that bind to Fc portion of immunoglobulin G (IgG). Through their antigen binding F(ab) end, antibodies bind to specific antigen while their constant (Fc) region binds to FCGRs on phagocytes. The clustering of FCGRs by IgG antibodies on the phagocyte initiates a variety of signals, which lead, through the reorganisation of actin cytoskeleton and membrane remodelling, to the formation of pseudopod and phagosome. Fc gamma receptors are classified into three classes: FCGRI, FCGRII and FCGRIII. Each class of these FCGRs consists of several individual isoforms. Among all these isoforms FCGRI, FCGRIIA and FCGRIIIA, are able to mediate phagocytosis (Joshi et al. 2006, Garcia Garcia & Rosales 2002, Nimmerjahn & Ravetch 2006). Source:Reactome.

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Bibliography

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  83. Ernst LK, Duchemin AM, Anderson CL.; ''Association of the high-affinity receptor for IgG (Fc gamma RI) with the gamma subunit of the IgE receptor.''; PubMed Europe PMC Scholia
  84. Tsang E, Giannetti AM, Shaw D, Dinh M, Tse JK, Gandhi S, Ho H, Wang S, Papp E, Bradshaw JM.; ''Molecular mechanism of the Syk activation switch.''; PubMed Europe PMC Scholia
  85. Swanson JA, Johnson MT, Beningo K, Post P, Mooseker M, Araki N.; ''A contractile activity that closes phagosomes in macrophages.''; PubMed Europe PMC Scholia
  86. Takeuchi M, Harigai M, Momohara S, Ball E, Abe J, Furuichi K, Kamatani N.; ''Cloning and characterization of DPPL1 and DPPL2, representatives of a novel type of mammalian phosphatidate phosphatase.''; PubMed Europe PMC Scholia
  87. Sekiya F, Poulin B, Kim YJ, Rhee SG.; ''Mechanism of tyrosine phosphorylation and activation of phospholipase C-gamma 1. Tyrosine 783 phosphorylation is not sufficient for lipase activation.''; PubMed Europe PMC Scholia
  88. Zalevsky J, Lempert L, Kranitz H, Mullins RD.; ''Different WASP family proteins stimulate different Arp2/3 complex-dependent actin-nucleating activities.''; PubMed Europe PMC Scholia
  89. Brooks DG, Qiu WQ, Luster AD, Ravetch JV.; ''Structure and expression of human IgG FcRII(CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes.''; PubMed Europe PMC Scholia
  90. Strzelecka A, Kwiatkowska K, Sobota A.; ''Tyrosine phosphorylation and Fcgamma receptor-mediated phagocytosis.''; PubMed Europe PMC Scholia
  91. Ghazizadeh S, Bolen JB, Fleit HB.; ''Tyrosine phosphorylation and association of Syk with Fc gamma RII in monocytic THP-1 cells.''; PubMed Europe PMC Scholia
  92. Cory GO, Garg R, Cramer R, Ridley AJ.; ''Phosphorylation of tyrosine 291 enhances the ability of WASp to stimulate actin polymerization and filopodium formation. Wiskott-Aldrich Syndrome protein.''; PubMed Europe PMC Scholia
  93. van Vugt MJ, Heijnen IA, Capel PJ, Park SY, Ra C, Saito T, Verbeek JS, van de Winkel JG.; ''FcR gamma-chain is essential for both surface expression and function of human Fc gamma RI (CD64) in vivo.''; PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
118475view20:32, 27 May 2021FinterlyRemoved incorrect and duplicated openControlledVocabulary PW:0000234
114947view16:47, 25 January 2021ReactomeTeamReactome version 75
113391view11:46, 2 November 2020ReactomeTeamReactome version 74
112853view13:31, 12 October 2020DeSlFixing ontology tag error
112849view13:02, 12 October 2020DeSlOntology Term : 'innate immune response pathway' added !
112596view15:57, 9 October 2020ReactomeTeamReactome version 73
101512view11:37, 1 November 2018ReactomeTeamreactome version 66
101048view21:19, 31 October 2018ReactomeTeamreactome version 65
100579view19:52, 31 October 2018ReactomeTeamreactome version 64
100128view16:38, 31 October 2018ReactomeTeamreactome version 63
99678view15:07, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99271view12:45, 31 October 2018ReactomeTeamreactome version 62
94053view13:54, 16 August 2017ReactomeTeamreactome version 61
93681view11:30, 9 August 2017ReactomeTeamreactome version 61
89466view13:21, 15 September 2016Mkutmonfix ontology tag annotation
87448view13:50, 22 July 2016MkutmonOntology Term : 'PW:0000234' added !
86805view09:26, 11 July 2016ReactomeTeamreactome version 56
83122view10:02, 18 November 2015ReactomeTeamVersion54
81461view12:59, 21 August 2015ReactomeTeamVersion53
76936view08:20, 17 July 2014ReactomeTeamFixed remaining interactions
76641view12:01, 16 July 2014ReactomeTeamFixed remaining interactions
75971view10:02, 11 June 2014ReactomeTeamRe-fixing comment source
75674view10:59, 10 June 2014ReactomeTeamReactome 48 Update
75029view13:54, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74673view08:44, 30 April 2014ReactomeTeamNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
2-LysophosphatidylcholineMetaboliteCHEBI:17504 (ChEBI)
ABL1ProteinP00519 (Uniprot-TrEMBL)
ACTB(1-375) ProteinP60709 (Uniprot-TrEMBL)
ACTG1 ProteinP63261 (Uniprot-TrEMBL)
ACTR2 ProteinP61160 (Uniprot-TrEMBL)
ACTR3 ProteinP61158 (Uniprot-TrEMBL)
ADP MetaboliteCHEBI:16761 (ChEBI)
ADPMetaboliteCHEBI:16761 (ChEBI)
AHCYL1 ProteinO43865 (Uniprot-TrEMBL)
AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramerComplexR-HSA-5226920 (Reactome)
ARAMetaboliteCHEBI:15843 (ChEBI)
ARP2/3 complex (ATP bound)ComplexR-HSA-1861670 (Reactome)
ARPC1A ProteinQ92747 (Uniprot-TrEMBL)
ARPC2 ProteinO15144 (Uniprot-TrEMBL)
ARPC3 ProteinO15145 (Uniprot-TrEMBL)
ARPC4 ProteinP59998 (Uniprot-TrEMBL)
ARPC5 ProteinO15511 (Uniprot-TrEMBL)
ATP MetaboliteCHEBI:15422 (ChEBI)
ATPMetaboliteCHEBI:15422 (ChEBI)
Actin filament bound Myosin-XComplexR-HSA-1861625 (Reactome)
Actin:ADPComplexR-HSA-202994 (Reactome)
Activated WAVE2 and

WASP/N-WASP:ARP2/3

complex:G-actin		ComplexR-HSA-442565 (Reactome)
Activated WAVE2 and WASP/N-WASPR-HSA-2197675 (Reactome)
Active LIMK1ComplexR-HSA-419630 (Reactome)
Antigen-antibody complexComplexR-HSA-173552 (Reactome)
BAIAP2 ProteinQ9UQB8 (Uniprot-TrEMBL)
BAIAP2ProteinQ9UQB8 (Uniprot-TrEMBL)
BRK1 ProteinQ8WUW1 (Uniprot-TrEMBL)
CD247-1 ProteinP20963-1 (Uniprot-TrEMBL)
CD3G ProteinP09693 (Uniprot-TrEMBL)
CDC42 ProteinP60953 (Uniprot-TrEMBL)
CDC42:GDPComplexR-HSA-418830 (Reactome)
CDC42:GTP, RAC1:GTPR-HSA-389778 (Reactome)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteinsComplexR-HSA-2197683 (Reactome)
CDC42:GTP:WASP/N-WASPComplexR-HSA-442584 (Reactome)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteinsComplexR-HSA-2197680 (Reactome)
CDC42:GTPComplexR-HSA-182921 (Reactome)
CFL1ProteinP23528 (Uniprot-TrEMBL)
CRK ProteinP46108 (Uniprot-TrEMBL)
CRK:DOCK180:ELMO1,ELMO2ComplexR-HSA-2029141 (Reactome)
CRKII:DOCK180:ELMO

complex recruited

to phagocytic cup		ComplexR-HSA-2029130 (Reactome)
CYFIP1 ProteinQ7L576 (Uniprot-TrEMBL)
CYFIP2 ProteinQ96F07 (Uniprot-TrEMBL)
Ca2+MetaboliteCHEBI:29108 (ChEBI)
DAGsMetaboliteCHEBI:18035 (ChEBI)
DOCK1 ProteinQ14185 (Uniprot-TrEMBL)
ELMO1 ProteinQ92556 (Uniprot-TrEMBL)
ELMO2 ProteinQ96JJ3 (Uniprot-TrEMBL)
F-actinR-HSA-201877 (Reactome)
FCGR1A ProteinP12314 (Uniprot-TrEMBL)
FCGR2A ProteinP12318 (Uniprot-TrEMBL)
FCGR2AProteinP12318 (Uniprot-TrEMBL)
FCGR3A ProteinP08637 (Uniprot-TrEMBL)
FCGRIA:CD3G homodimerComplexR-HSA-2029093 (Reactome)
FCGRIIIA:CD3G/CD3Z dimersComplexR-HSA-2029097 (Reactome)
G-actinComplexR-HSA-201857 (Reactome)
GDP MetaboliteCHEBI:17552 (ChEBI)
GDPMetaboliteCHEBI:17552 (ChEBI)
GRB2-1 ProteinP62993-1 (Uniprot-TrEMBL)
GTP MetaboliteCHEBI:15996 (ChEBI)
GTPMetaboliteCHEBI:15996 (ChEBI)
H2OMetaboliteCHEBI:15377 (ChEBI)
HSP90AA1 ProteinP07900 (Uniprot-TrEMBL)
HSP90AA1,HSP90AB1R-HSA-419619 (Reactome)
HSP90AB1 ProteinP08238 (Uniprot-TrEMBL)
I(1,4,5)P3 MetaboliteCHEBI:16595 (ChEBI)
I(1,4,5)P3MetaboliteCHEBI:16595 (ChEBI)
IGHG1 ProteinP01857 (Uniprot-TrEMBL)
IGHG2 ProteinP01859 (Uniprot-TrEMBL)
IGHG3 ProteinP01860 (Uniprot-TrEMBL)
IGHG4 ProteinP01861 (Uniprot-TrEMBL)
IGHV(1-?) ProteinA2KUC3 (Uniprot-TrEMBL)
IGHV7-81(1-?) ProteinQ6PIL0 (Uniprot-TrEMBL)
IGKC ProteinP01834 (Uniprot-TrEMBL)
IGKV1-5(23-?) ProteinP01602 (Uniprot-TrEMBL)
IGKV4-1(21-?) ProteinP06312 (Uniprot-TrEMBL)
IGKVA18(21-?) ProteinA2NJV5 (Uniprot-TrEMBL)
IGLC1 ProteinP0CG04 (Uniprot-TrEMBL)
IGLC2 ProteinP0CG05 (Uniprot-TrEMBL)
IGLC3 ProteinP0CG06 (Uniprot-TrEMBL)
IGLC6 ProteinP0CF74 (Uniprot-TrEMBL)
IGLC7 ProteinA0M8Q6 (Uniprot-TrEMBL)
IGLV(23-?) ProteinA2NXD2 (Uniprot-TrEMBL)
IGLV1-36(1-?) ProteinQ5NV67 (Uniprot-TrEMBL)
IGLV1-40(1-?) ProteinQ5NV69 (Uniprot-TrEMBL)
IGLV1-44(1-?) ProteinQ5NV81 (Uniprot-TrEMBL)
IGLV10-54(1-?) ProteinQ5NV86 (Uniprot-TrEMBL)
IGLV11-55(1-?) ProteinQ5NV87 (Uniprot-TrEMBL)
IGLV2-11(1-?) ProteinQ5NV84 (Uniprot-TrEMBL)
IGLV2-18(1-?) ProteinQ5NV65 (Uniprot-TrEMBL)
IGLV2-23(1-?) ProteinQ5NV89 (Uniprot-TrEMBL)
IGLV2-33(1-?) ProteinQ5NV66 (Uniprot-TrEMBL)
IGLV3-12(1-?) ProteinQ5NV85 (Uniprot-TrEMBL)
IGLV3-16(1-?) ProteinQ5NV64 (Uniprot-TrEMBL)
IGLV3-22(1-?) ProteinQ5NV75 (Uniprot-TrEMBL)
IGLV3-25(1-?) ProteinQ5NV90 (Uniprot-TrEMBL)
IGLV3-27(1-?) ProteinQ5NV91 (Uniprot-TrEMBL)
IGLV4-3(1-?) ProteinQ5NV61 (Uniprot-TrEMBL)
IGLV4-60(1-?) ProteinQ5NV79 (Uniprot-TrEMBL)
IGLV4-69(1-?) ProteinQ5NV92 (Uniprot-TrEMBL)
IGLV5-37(1-?) ProteinQ5NV68 (Uniprot-TrEMBL)
IGLV5-45(1-?) ProteinQ5NV82 (Uniprot-TrEMBL)
IGLV7-43(1-?) ProteinQ5NV80 (Uniprot-TrEMBL)
IGLV7-46(1-?) ProteinQ5NV83 (Uniprot-TrEMBL)
IGLV8-61(1-?) ProteinQ5NV62 (Uniprot-TrEMBL)
IP3 receptor homotetramerComplexR-HSA-169686 (Reactome)
ITPR1 ProteinQ14643 (Uniprot-TrEMBL)
ITPR2 ProteinQ14571 (Uniprot-TrEMBL)
ITPR3 ProteinQ14573 (Uniprot-TrEMBL)
ITPR:I(1,4,5)P3 tetramerComplexR-HSA-169696 (Reactome)
Ig heavy chain V-I region EU ProteinP01742 (Uniprot-TrEMBL)
Ig heavy chain V-I region HG3 ProteinP01743 (Uniprot-TrEMBL)
Ig heavy chain V-I region Mot ProteinP06326 (Uniprot-TrEMBL)
Ig heavy chain V-I region ND ProteinP01744 (Uniprot-TrEMBL)
Ig heavy chain V-I region SIE ProteinP01761 (Uniprot-TrEMBL)
Ig heavy chain V-I region WOL ProteinP01760 (Uniprot-TrEMBL)
Ig heavy chain V-II region ARH-77 ProteinP06331 (Uniprot-TrEMBL)
Ig heavy chain V-II region COR ProteinP01815 (Uniprot-TrEMBL)
Ig heavy chain V-II region DAW ProteinP01816 (Uniprot-TrEMBL)
Ig heavy chain V-II region HE ProteinP01818 (Uniprot-TrEMBL)
Ig heavy chain V-II region MCE ProteinP01817 (Uniprot-TrEMBL)
Ig heavy chain V-II region NEWM ProteinP01825 (Uniprot-TrEMBL)
Ig heavy chain V-II region OU ProteinP01814 (Uniprot-TrEMBL)
Ig heavy chain V-II region SESS ProteinP04438 (Uniprot-TrEMBL)
Ig heavy chain V-II region WAH ProteinP01824 (Uniprot-TrEMBL)
Ig heavy chain V-III region BRO ProteinP01766 (Uniprot-TrEMBL)
Ig heavy chain V-III region BUR ProteinP01773 (Uniprot-TrEMBL)
Ig heavy chain V-III region BUT ProteinP01767 (Uniprot-TrEMBL)
Ig heavy chain V-III region CAM ProteinP01768 (Uniprot-TrEMBL)
Ig heavy chain V-III region DOB ProteinP01782 (Uniprot-TrEMBL)
Ig heavy chain V-III region GA ProteinP01769 (Uniprot-TrEMBL)
Ig heavy chain V-III region GAL ProteinP01781 (Uniprot-TrEMBL)
Ig heavy chain V-III region HIL ProteinP01771 (Uniprot-TrEMBL)
Ig heavy chain V-III region JON ProteinP01780 (Uniprot-TrEMBL)
Ig heavy chain V-III region KOL ProteinP01772 (Uniprot-TrEMBL)
Ig heavy chain V-III region LAY ProteinP01775 (Uniprot-TrEMBL)
Ig heavy chain V-III region NIE ProteinP01770 (Uniprot-TrEMBL)
Ig heavy chain V-III region POM ProteinP01774 (Uniprot-TrEMBL)
Ig heavy chain V-III region TEI ProteinP01777 (Uniprot-TrEMBL)
Ig heavy chain V-III region TIL ProteinP01765 (Uniprot-TrEMBL)
Ig heavy chain V-III region TRO ProteinP01762 (Uniprot-TrEMBL)
Ig heavy chain V-III region TUR ProteinP01779 (Uniprot-TrEMBL)
Ig heavy chain V-III region WAS ProteinP01776 (Uniprot-TrEMBL)
Ig heavy chain V-III region WEA ProteinP01763 (Uniprot-TrEMBL)
Ig heavy chain V-III region ZAP ProteinP01778 (Uniprot-TrEMBL)
Ig kappa chain V region EV15 ProteinP06315 (Uniprot-TrEMBL)
Ig kappa chain V-I region AG ProteinP01593 (Uniprot-TrEMBL)
Ig kappa chain V-I region AU ProteinP01594 (Uniprot-TrEMBL)
Ig kappa chain V-I region BAN ProteinP04430 (Uniprot-TrEMBL)
Ig kappa chain V-I region Bi ProteinP01595 (Uniprot-TrEMBL)
Ig kappa chain V-I region CAR ProteinP01596 (Uniprot-TrEMBL)
Ig kappa chain V-I region DEE ProteinP01597 (Uniprot-TrEMBL)
Ig kappa chain V-I region Daudi ProteinP04432 (Uniprot-TrEMBL)
Ig kappa chain V-I region EU ProteinP01598 (Uniprot-TrEMBL)
Ig kappa chain V-I region Gal ProteinP01599 (Uniprot-TrEMBL)
Ig kappa chain V-I region HK101 ProteinP01601 (Uniprot-TrEMBL)
Ig kappa chain V-I region Hau ProteinP01600 (Uniprot-TrEMBL)
Ig kappa chain V-I region Ka ProteinP01603 (Uniprot-TrEMBL)
Ig kappa chain V-I region Kue ProteinP01604 (Uniprot-TrEMBL)
Ig kappa chain V-I region Lay ProteinP01605 (Uniprot-TrEMBL)
Ig kappa chain V-I region Mev ProteinP01612 (Uniprot-TrEMBL)
Ig kappa chain V-I region Ni ProteinP01613 (Uniprot-TrEMBL)
Ig kappa chain V-I region OU ProteinP01606 (Uniprot-TrEMBL)
Ig kappa chain V-I region Rei ProteinP01607 (Uniprot-TrEMBL)
Ig kappa chain V-I region Roy ProteinP01608 (Uniprot-TrEMBL)
Ig kappa chain V-I region Scw ProteinP01609 (Uniprot-TrEMBL)
Ig kappa chain V-I region WAT ProteinP80362 (Uniprot-TrEMBL)
Ig kappa chain V-I region WEA ProteinP01610 (Uniprot-TrEMBL)
Ig kappa chain V-I region Walker ProteinP04431 (Uniprot-TrEMBL)
Ig kappa chain V-I region Wes ProteinP01611 (Uniprot-TrEMBL)
Ig kappa chain V-II region Cum ProteinP01614 (Uniprot-TrEMBL)
Ig kappa chain V-II region FR ProteinP01615 (Uniprot-TrEMBL)
Ig kappa chain V-II region GM607 ProteinP06309 (Uniprot-TrEMBL)
Ig kappa chain V-II region MIL ProteinP01616 (Uniprot-TrEMBL)
Ig kappa chain V-II region RPMI 6410 ProteinP06310 (Uniprot-TrEMBL)
Ig kappa chain V-II region TEW ProteinP01617 (Uniprot-TrEMBL)
Ig kappa chain V-III region B6 ProteinP01619 (Uniprot-TrEMBL)
Ig kappa chain V-III region CLL ProteinP04207 (Uniprot-TrEMBL)
Ig kappa chain V-III region GOL ProteinP04206 (Uniprot-TrEMBL)
Ig kappa chain V-III region HAH ProteinP18135 (Uniprot-TrEMBL)
Ig kappa chain V-III region HIC ProteinP18136 (Uniprot-TrEMBL)
Ig kappa chain V-III region IARC/BL41 ProteinP06311 (Uniprot-TrEMBL)
Ig kappa chain V-III region NG9 ProteinP01621 (Uniprot-TrEMBL)
Ig kappa chain V-III region POM ProteinP01624 (Uniprot-TrEMBL)
Ig kappa chain V-III region SIE ProteinP01620 (Uniprot-TrEMBL)
Ig kappa chain V-III region Ti ProteinP01622 (Uniprot-TrEMBL)
Ig kappa chain V-III region VG ProteinP04433 (Uniprot-TrEMBL)
Ig kappa chain V-III region VH ProteinP04434 (Uniprot-TrEMBL)
Ig kappa chain V-III region WOL ProteinP01623 (Uniprot-TrEMBL)
Ig kappa chain V-IV region B17 ProteinP06314 (Uniprot-TrEMBL)
Ig kappa chain V-IV region JI ProteinP06313 (Uniprot-TrEMBL)
Ig kappa chain V-IV region Len ProteinP01625 (Uniprot-TrEMBL)
Ig kappa chain V-IV region STH ProteinP83593 (Uniprot-TrEMBL)
Ig lambda chain V-III region LOI ProteinP80748 (Uniprot-TrEMBL)
Ig lambda chain V-III region SH ProteinP01714 (Uniprot-TrEMBL)
Ig lambda chain V-VII region MOT ProteinP01720 (Uniprot-TrEMBL)
Ig lambda chain V region 4A ProteinP04211 (Uniprot-TrEMBL)
Ig lambda chain V-I region BL2 ProteinP06316 (Uniprot-TrEMBL)
Ig lambda chain V-I region EPS ProteinP06888 (Uniprot-TrEMBL)
Ig lambda chain V-I region HA ProteinP01700 (Uniprot-TrEMBL)
Ig lambda chain V-I region MEM ProteinP06887 (Uniprot-TrEMBL)
Ig lambda chain V-I region NEW ProteinP01701 (Uniprot-TrEMBL)
Ig lambda chain V-I region NEWM ProteinP01703 (Uniprot-TrEMBL)
Ig lambda chain V-I region NIG-64 ProteinP01702 (Uniprot-TrEMBL)
Ig lambda chain V-I region VOR ProteinP01699 (Uniprot-TrEMBL)
Ig lambda chain V-I region WAH ProteinP04208 (Uniprot-TrEMBL)
Ig lambda chain V-II region BO ProteinP01710 (Uniprot-TrEMBL)
Ig lambda chain V-II region BOH ProteinP01706 (Uniprot-TrEMBL)
Ig lambda chain V-II region BUR ProteinP01708 (Uniprot-TrEMBL)
Ig lambda chain V-II region MGC ProteinP01709 (Uniprot-TrEMBL)
Ig lambda chain V-II region NEI ProteinP01705 (Uniprot-TrEMBL)
Ig lambda chain V-II region NIG-58 ProteinP01713 (Uniprot-TrEMBL)
Ig lambda chain V-II region NIG-84 ProteinP04209 (Uniprot-TrEMBL)
Ig lambda chain V-II region TOG ProteinP01704 (Uniprot-TrEMBL)
Ig lambda chain V-II region TRO ProteinP01707 (Uniprot-TrEMBL)
Ig lambda chain V-II region VIL ProteinP01711 (Uniprot-TrEMBL)
Ig lambda chain V-II region WIN ProteinP01712 (Uniprot-TrEMBL)
Ig lambda chain V-IV region Bau ProteinP01715 (Uniprot-TrEMBL)
Ig lambda chain V-IV region Hil ProteinP01717 (Uniprot-TrEMBL)
Ig lambda chain V-IV region Kern ProteinP01718 (Uniprot-TrEMBL)
Ig lambda chain V-IV region MOL ProteinP06889 (Uniprot-TrEMBL)
Ig lambda chain V-IV region X ProteinP01716 (Uniprot-TrEMBL)
Ig lambda chain V-V region DEL ProteinP01719 (Uniprot-TrEMBL)
Ig lambda chain V-VI region AR ProteinP01721 (Uniprot-TrEMBL)
Ig lambda chain V-VI region EB4 ProteinP06319 (Uniprot-TrEMBL)
Ig lambda chain V-VI region NIG-48 ProteinP01722 (Uniprot-TrEMBL)
Ig lambda chain V-VI region SUT ProteinP06317 (Uniprot-TrEMBL)
Ig lambda chain V-VI region WLT ProteinP06318 (Uniprot-TrEMBL)
IgG-Ag:FCGRIA:CD3G homodimerComplexR-HSA-2029132 (Reactome)
IgG-Ag:FCGRIIAComplexR-HSA-1861689 (Reactome)
IgG-Ag:FCGRIIIA:CD3G/CD3Z dimersComplexR-HSA-2029163 (Reactome)
IgH heavy chain

V-III region VH26

precursor 		ProteinP01764 (Uniprot-TrEMBL)
LIMK1ProteinP53667 (Uniprot-TrEMBL)
MYO10 ProteinQ9HD67 (Uniprot-TrEMBL)
Mother filament:ARP2/3:actin:GDPComplexR-HSA-2197686 (Reactome)
Mother

filament:branching complex:daughter

filament		ComplexR-HSA-1861699 (Reactome)
Mother

filament:branching

complex		ComplexR-HSA-2029140 (Reactome)
Myosin-Actin filamentsComplexR-HSA-2029139 (Reactome)
Myosin-X dimerComplexR-HSA-1861665 (Reactome)
MyosinR-HSA-2029109 (Reactome)
N-WASP ProteinO00401 (Uniprot-TrEMBL)
NAD+ MetaboliteCHEBI:15846 (ChEBI)
NCK1 ProteinP16333 (Uniprot-TrEMBL)
NCKAP1 ProteinQ9Y2A7 (Uniprot-TrEMBL)
NCKAP1L ProteinP55160 (Uniprot-TrEMBL)
NCKIPSD ProteinQ9NZQ3 (Uniprot-TrEMBL)
PAMetaboliteCHEBI:16337 (ChEBI)
PAK1 ProteinQ13153 (Uniprot-TrEMBL)
PAK1 dimerComplexR-HSA-445002 (Reactome)
PAK1ProteinQ13153 (Uniprot-TrEMBL)
PCMetaboliteCHEBI:16110 (ChEBI)
PI(3,4)P2 MetaboliteCHEBI:16152 (ChEBI)
PI(3,4)P2MetaboliteCHEBI:16152 (ChEBI)
PI(3,4,5)P3 MetaboliteCHEBI:16618 (ChEBI)
PI(3,4,5)P3MetaboliteCHEBI:16618 (ChEBI)
PI(4,5)P2 MetaboliteCHEBI:18348 (ChEBI)
PI(4,5)P2MetaboliteCHEBI:18348 (ChEBI)
PI3K:p-6Y-SYKComplexR-HSA-2029149 (Reactome)
PI3KComplexR-HSA-74693 (Reactome)
PIK3CA ProteinP42336 (Uniprot-TrEMBL)
PIK3CB ProteinP42338 (Uniprot-TrEMBL)
PIK3R1 ProteinP27986 (Uniprot-TrEMBL)
PIK3R2 ProteinO00459 (Uniprot-TrEMBL)
PKC-delta/epsilonR-HSA-198276 (Reactome)
PLA2G6ProteinO60733 (Uniprot-TrEMBL)
PLC gamma1,2R-HSA-1169089 (Reactome)
PLCG1 ProteinP19174 (Uniprot-TrEMBL)
PLCG2 ProteinP16885 (Uniprot-TrEMBL)
PLDR-HSA-2029102 (Reactome)
Phosphatidate phosphataseR-HSA-2029101 (Reactome)
PhosphatidylcholineMetaboliteCHEBI:16110 (ChEBI)
Phospho-PKC-delta/epsilonR-HSA-198265 (Reactome)
PiMetaboliteCHEBI:18367 (ChEBI)
RAC1 ProteinP63000 (Uniprot-TrEMBL)
RAC1/CDC42:PAK dimerComplexR-HSA-2029159 (Reactome)
RAC1/CDC42:p-S144,T423-PAKComplexR-HSA-2029155 (Reactome)
RAC1:GDPComplexR-HSA-5674631 (Reactome)
RAC1:GTPComplexR-HSA-442641 (Reactome)
SH3 domain proteinsR-HSA-2197679 (Reactome)
SYK ProteinP43405 (Uniprot-TrEMBL)
SYKProteinP43405 (Uniprot-TrEMBL)
Src family kinases (SFKs)R-HSA-1861597 (Reactome)
Src-kinasesR-HSA-2197681 (Reactome)
VAV1 ProteinP15498 (Uniprot-TrEMBL)
VAV1,2,3R-HSA-430172 (Reactome)
VAV2 ProteinP52735 (Uniprot-TrEMBL)
VAV3 ProteinQ9UKW4 (Uniprot-TrEMBL)
WAS ProteinP42768 (Uniprot-TrEMBL)
WASP/N-WASPR-HSA-201892 (Reactome)
WAVE Regulatory ComplexComplexR-HSA-2029154 (Reactome)
WIP family proteinsR-HSA-2197678 (Reactome)
WIPF1 ProteinO43516 (Uniprot-TrEMBL)
WIPF2 ProteinQ8TF74 (Uniprot-TrEMBL)
WIPF3 ProteinA6NGB9 (Uniprot-TrEMBL)
WRC:IRSp53/58:RAC1:GTP:PIP3ComplexR-HSA-2029147 (Reactome)
cholineMetaboliteCHEBI:15354 (ChEBI)
clustered IgG-Ag:FCGRsComplexR-HSA-2029146 (Reactome)
clustered IgG-Ag:p-FCGRs:SYKComplexR-HSA-2029129 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCGComplexR-HSA-2029137 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAVComplexR-HSA-2029133 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCGComplexR-HSA-2029156 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-VAVComplexR-HSA-2029131 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYKComplexR-HSA-2029158 (Reactome)
clustered IgG-Ag:p-FCGRsComplexR-HSA-2029128 (Reactome)
clustered IgG-Ag:p-FCGRsComplexR-HSA-2029151 (Reactome)
p-4Y-PLCG1 ProteinP19174 (Uniprot-TrEMBL)
p-4Y-PLCG1ProteinP19174 (Uniprot-TrEMBL)
p-6Y-CD247-1 ProteinP20963-1 (Uniprot-TrEMBL)
p-6Y-SYK ProteinP43405 (Uniprot-TrEMBL)
p-PLCGR-HSA-2029095 (Reactome)
p-S,T508-LIMK1 ProteinP53667 (Uniprot-TrEMBL)
p-S144,T423-PAK1 ProteinQ13153 (Uniprot-TrEMBL)
p-S144,T423-PAK1ProteinQ13153 (Uniprot-TrEMBL)
p-S3-CFL1 ProteinP23528 (Uniprot-TrEMBL)
p-T,Y MAPK dimersR-HSA-1268261 (Reactome)
p-T508-LIMK1 ProteinP53667 (Uniprot-TrEMBL)
p-T508-LIMK1ProteinP53667 (Uniprot-TrEMBL)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3ComplexR-HSA-2029148 (Reactome)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3ComplexR-HSA-2130182 (Reactome)
p-Y160,Y171-CD3G ProteinP09693 (Uniprot-TrEMBL)
p-Y172-VAV2 ProteinP52735 (Uniprot-TrEMBL)
p-Y173-VAV3 ProteinQ9UKW4 (Uniprot-TrEMBL)
p-Y174-VAV1 ProteinP15498 (Uniprot-TrEMBL)
p-Y256-WASL ProteinO00401 (Uniprot-TrEMBL)
p-Y288,Y304-FCGR2A ProteinP12318 (Uniprot-TrEMBL)
p-Y291-WAS ProteinP42768 (Uniprot-TrEMBL)
p-Y753,Y759,Y1217-PLCG2 ProteinP16885 (Uniprot-TrEMBL)
pCofilin: Active LIMK-1ComplexR-HSA-399878 (Reactome)
pLIMK dimer:HSP-90ComplexR-HSA-419632 (Reactome)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
2-LysophosphatidylcholineArrowR-HSA-2029475 (Reactome)
ABL1mim-catalysisR-HSA-2130194 (Reactome)
ADPArrowR-HSA-198314 (Reactome)
ADPArrowR-HSA-2029268 (Reactome)
ADPArrowR-HSA-2029271 (Reactome)
ADPArrowR-HSA-2029449 (Reactome)
ADPArrowR-HSA-2029453 (Reactome)
ADPArrowR-HSA-2029454 (Reactome)
ADPArrowR-HSA-2029459 (Reactome)
ADPArrowR-HSA-2029460 (Reactome)
ADPArrowR-HSA-2029469 (Reactome)
ADPArrowR-HSA-2130194 (Reactome)
ADPArrowR-HSA-2197698 (Reactome)
ADPArrowR-HSA-399950 (Reactome)
ADPArrowR-HSA-419644 (Reactome)
AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramerTBarR-HSA-169683 (Reactome)
ARAArrowR-HSA-2029475 (Reactome)
ARP2/3 complex (ATP bound)R-HSA-442592 (Reactome)
ATPR-HSA-1861595 (Reactome)
ATPR-HSA-198314 (Reactome)
ATPR-HSA-2029268 (Reactome)
ATPR-HSA-2029271 (Reactome)
ATPR-HSA-2029449 (Reactome)
ATPR-HSA-2029453 (Reactome)
ATPR-HSA-2029454 (Reactome)
ATPR-HSA-2029459 (Reactome)
ATPR-HSA-2029460 (Reactome)
ATPR-HSA-2029469 (Reactome)
ATPR-HSA-2029476 (Reactome)
ATPR-HSA-2130194 (Reactome)
ATPR-HSA-2197698 (Reactome)
ATPR-HSA-399950 (Reactome)
ATPR-HSA-419644 (Reactome)
Actin filament bound Myosin-XArrowR-HSA-1861595 (Reactome)
Actin:ADPArrowR-HSA-2029473 (Reactome)
Activated WAVE2 and

WASP/N-WASP:ARP2/3

complex:G-actin		ArrowR-HSA-442592 (Reactome)
Activated WAVE2 and

WASP/N-WASP:ARP2/3

complex:G-actin		R-HSA-2029466 (Reactome)
Activated WAVE2 and WASP/N-WASPArrowR-HSA-2197690 (Reactome)
Activated WAVE2 and WASP/N-WASPR-HSA-442592 (Reactome)
Active LIMK1ArrowR-HSA-419644 (Reactome)
Active LIMK1R-HSA-399950 (Reactome)
Active LIMK1mim-catalysisR-HSA-399950 (Reactome)
Antigen-antibody complexR-HSA-1861621 (Reactome)
Antigen-antibody complexR-HSA-2029455 (Reactome)
Antigen-antibody complexR-HSA-2029457 (Reactome)
BAIAP2R-HSA-2029465 (Reactome)
CDC42:GDPR-HSA-2029445 (Reactome)
CDC42:GTP, RAC1:GTPR-HSA-2029456 (Reactome)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteinsArrowR-HSA-2197691 (Reactome)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteinsR-HSA-2197698 (Reactome)
CDC42:GTP:WASP/N-WASPArrowR-HSA-442586 (Reactome)
CDC42:GTP:WASP/N-WASPR-HSA-2197691 (Reactome)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteinsArrowR-HSA-2197698 (Reactome)
CDC42:GTPArrowR-HSA-2029445 (Reactome)
CDC42:GTPR-HSA-442586 (Reactome)
CFL1R-HSA-399950 (Reactome)
CRK:DOCK180:ELMO1,ELMO2R-HSA-2197697 (Reactome)
CRKII:DOCK180:ELMO

complex recruited

to phagocytic cup		ArrowR-HSA-2197697 (Reactome)
CRKII:DOCK180:ELMO

complex recruited

to phagocytic cup		mim-catalysisR-HSA-2029467 (Reactome)
Ca2+ArrowR-HSA-169683 (Reactome)
Ca2+R-HSA-169683 (Reactome)
DAGsArrowR-HSA-167686 (Reactome)
DAGsArrowR-HSA-198314 (Reactome)
DAGsArrowR-HSA-2029468 (Reactome)
F-actinR-HSA-2029466 (Reactome)
FCGR2AR-HSA-1861621 (Reactome)
FCGRIA:CD3G homodimerR-HSA-2029455 (Reactome)
FCGRIIIA:CD3G/CD3Z dimersR-HSA-2029457 (Reactome)
G-actinR-HSA-2029473 (Reactome)
G-actinR-HSA-442592 (Reactome)
GDPArrowR-HSA-2029445 (Reactome)
GDPArrowR-HSA-2029451 (Reactome)
GDPArrowR-HSA-2029467 (Reactome)
GTPR-HSA-2029445 (Reactome)
GTPR-HSA-2029451 (Reactome)
GTPR-HSA-2029467 (Reactome)
H2OR-HSA-167686 (Reactome)
H2OR-HSA-2029468 (Reactome)
H2OR-HSA-2029471 (Reactome)
H2OR-HSA-2029475 (Reactome)
HSP90AA1,HSP90AB1ArrowR-HSA-419644 (Reactome)
HSP90AA1,HSP90AB1R-HSA-419645 (Reactome)
I(1,4,5)P3ArrowR-HSA-167686 (Reactome)
I(1,4,5)P3ArrowR-HSA-169683 (Reactome)
I(1,4,5)P3R-HSA-169680 (Reactome)
IP3 receptor homotetramerR-HSA-169680 (Reactome)
ITPR:I(1,4,5)P3 tetramerArrowR-HSA-169680 (Reactome)
ITPR:I(1,4,5)P3 tetramermim-catalysisR-HSA-169683 (Reactome)
IgG-Ag:FCGRIA:CD3G homodimerArrowR-HSA-2029455 (Reactome)
IgG-Ag:FCGRIIAArrowR-HSA-1861621 (Reactome)
IgG-Ag:FCGRIIIA:CD3G/CD3Z dimersArrowR-HSA-2029457 (Reactome)
LIMK1R-HSA-2029460 (Reactome)
Mother filament:ARP2/3:actin:GDPArrowR-HSA-2197690 (Reactome)
Mother filament:ARP2/3:actin:GDPR-HSA-2029473 (Reactome)
Mother

filament:branching complex:daughter

filament		ArrowR-HSA-2029473 (Reactome)
Mother

filament:branching complex:daughter

filament		R-HSA-1861595 (Reactome)
Mother

filament:branching complex:daughter

filament		R-HSA-2029476 (Reactome)
Mother

filament:branching

complex		ArrowR-HSA-2029466 (Reactome)
Mother

filament:branching

complex		R-HSA-2197690 (Reactome)
Myosin-Actin filamentsArrowR-HSA-2029476 (Reactome)
Myosin-X dimerR-HSA-1861595 (Reactome)
Myosin-X dimermim-catalysisR-HSA-1861595 (Reactome)
MyosinR-HSA-2029476 (Reactome)
PAArrowR-HSA-2029471 (Reactome)
PAK1 dimerR-HSA-2029456 (Reactome)
PAK1mim-catalysisR-HSA-2029454 (Reactome)
PAR-HSA-2029468 (Reactome)
PCR-HSA-2029471 (Reactome)
PI(3,4)P2R-HSA-1861595 (Reactome)
PI(3,4,5)P3ArrowR-HSA-2029271 (Reactome)
PI(3,4,5)P3ArrowR-HSA-2029272 (Reactome)
PI(3,4,5)P3R-HSA-2029268 (Reactome)
PI(3,4,5)P3R-HSA-2029458 (Reactome)
PI(3,4,5)P3R-HSA-2029465 (Reactome)
PI(4,5)P2R-HSA-167686 (Reactome)
PI(4,5)P2R-HSA-2029271 (Reactome)
PI(4,5)P2R-HSA-442586 (Reactome)
PI3K:p-6Y-SYKArrowR-HSA-2029273 (Reactome)
PI3K:p-6Y-SYKmim-catalysisR-HSA-2029271 (Reactome)
PI3KR-HSA-2029273 (Reactome)
PKC-delta/epsilonR-HSA-198314 (Reactome)
PKC-delta/epsilonmim-catalysisR-HSA-198314 (Reactome)
PLA2G6mim-catalysisR-HSA-2029475 (Reactome)
PLC gamma1,2R-HSA-2029270 (Reactome)
PLDmim-catalysisR-HSA-2029471 (Reactome)
Phosphatidate phosphatasemim-catalysisR-HSA-2029468 (Reactome)
PhosphatidylcholineR-HSA-2029475 (Reactome)
Phospho-PKC-delta/epsilonArrowR-HSA-198314 (Reactome)
PiArrowR-HSA-1861595 (Reactome)
PiArrowR-HSA-2029468 (Reactome)
PiArrowR-HSA-2029473 (Reactome)
PiArrowR-HSA-2029476 (Reactome)
R-HSA-167686 (Reactome) Inositol 1,4,5-triphosphate (IP3) is a second messenger produced by phospholipase C (PLC) metabolism of phosphoinositol 4,5-bisphosphate (PIP2) (Canossa et al. 2001).
R-HSA-169680 (Reactome) The IP3 receptor (IP3R) is an IP3-gated calcium channel. It is a large, homotetrameric protein, similar to other calcium channel proteins such as ryanodine. The four subunits form a 'four-leafed clover' structure arranged around the central calcium channel. Binding of ligands such as IP3 results in conformational changes in the receptor's structure that leads to channel opening.
R-HSA-169683 (Reactome) IP3 promotes the release of intracellular calcium.
R-HSA-1861595 (Reactome) Myosin-X (Myosin 10) is one of the downstream effectors of PI3K in FCGR-phagocytosis and is involved in pseudopod extension and closure of phagocytic cups. It is recruited to the forming phagosome by binding, through its second PH domain to membrane PIP3, a major product of PI3-kinase (Cox et al. 2002). Myosin-X may act as a motor to transport membrane cargo molecules to the forming pseudopods, influencing actin dynamics. It is not understood with certainty how myosin X contributes to the mechanism of pseudopod extension. It selectively binds to actin bundle such that each head may bind, in an ATP-sensitive manner, to two adjacent actin filaments within the actin bundle. Myosin X hydrolyze ATP and converts this chemical energy to mechanical energy moving toward the plus end/barbed end of the actin filament facing towards the tip of the growing pseudopods (Araki 2006, Chavrier 2003, Watanabe et al 2010).
R-HSA-1861621 (Reactome) FCGRII (CD32) is a low-affinity receptor encoded by three different genes (A, B and C) (Brooks et al. 1989). FCGRIIA functions as a single-chain transmembrane receptor containing both the ligand-binding extracellular domain and a signal transducing cytoplasmic domain that contains distinct immunoreceptor tyrosine-based activation motif (ITAM). This ITAM-like domain in FCGRIIA contains two YXXL motifs with a spacer sequence of 12 amino acids instead of the usual 7. Isoform FCGRIIB is expressed in various leukocytes, including human monocytes and, as opposed to the activating Fc receptors it has an immunoreceptor tyrosine-based inhibitory motif (ITIM) and negatively regulates phagocytosis (Van den Herik-Oudijk IE et al. 1995, Mitchell et al. 1994, Tridandapani et al. 2002).
The first step in Fc-gamma receptor (FCGR) phagocytosis is binding and clustering of FCGRs by IgG-coated foreign particles. FCGR are clustered at the cell surface by multivalent antigen-antibody complexes and recruited to lipid raft micro domains; monovalent ligand binding is insufficient to generate a signal. This cross-linking results in the localization of FCGRs into lipid rafts and this may aid in recruiting and complexing with additional signalling proteins associated with lipid rafts (Bournazos et al. 2009, Kwiatkowska & Sobota 2001, Kono et al. 2002). This is followed by phosphorylation of the tyrosine residues within the ITAM located on the cytoplasmic portion of FCGRIIA by membrane-associated tyrosine kinases of the Src family (Mitchell et al. 1994).
R-HSA-198314 (Reactome) Diacylglycerol (DAG) positively regulates the autophosphorylation of protein kinase C-delta (PKC-delta), which stimulates ERK1/2 and triggers neurite outgrowth. DAG also stimulates the translocation of PKC from the cytosol to the plasma membrane. PKC-delta contributes to growth factor specificity and response to neuronal cells by promoting cell-type-specific differences in growth factor signalling. DAG can also activate PKC-epsilon in the same manner.
R-HSA-2029268 (Reactome) PLCG is tyrosine phosphorylated by either SYK or Src kinases on three tyrosine residues and this phosphorylation enhances the activity of PLCG. Although maximal activation requires binding of PLCG to PIP3 with its plecstrin homology (PH) domain.
R-HSA-2029270 (Reactome) PLCgamma (PLCG) is recruited to FCGR and the phosphorylated Y342 and Y346 in SYK have been reported to be involved in the interaction of PLCG (Law et al. 1996). PLCG accumulates at the phagocytic cup during FCGR, but the exact role of PLCG in the regulation of phagocytosis is not clear. It may be involved in FCGR signaling by activating PKC through DAG production (Garcia-Garcia & Rosales 2002 )
R-HSA-2029271 (Reactome) Activated PI3K phosphorylates phosphatidylinositol (PI) 4-phosphate and PI 4,5-bisphosphate (PIP2) to generate PI 3,4-bisphosphate and PI 3,4,5-triphosphate (PIP3) and these second messengers recruit other signaling proteins containing plecstrin homology (PH) domain. PIP3 rapidly accumulates at sites of phagocytosis and disappears after the phagosome has been sealed off from the plasma membrane.
R-HSA-2029272 (Reactome) Activated PLCG translocates to the plasmamembrane and interacts with the inositol ring of the membrane bound phosphatidylinositol 4,5-bisphosphate (PIP2) with its PH domain. The active enzyme promotes intracelllular signaling by catalysing the hydrolysis of PIP2 to generate the second messengers IP3 and DAG.
R-HSA-2029273 (Reactome) PI3K is one of the downstream effector of activated SYK. The p85 alpha regulatory subunit of PI3K have been shown to interact with SYK and FCGRs, and transient and restricted accumulation of lipid products of the kinase have been observed at sites of the phagosomal cup (Yanagi et al. 1994, Marshall et al. 2001). Leverrier at al. has demonstrated that p110beta is the major class I catalytic isoform required for FCGR-mediated phagocytosis by primary macrophages (Leverrier at al. 2003). p85 alpha subunit interacts with phosphorylated SYK at tyrosine 317 with its C-terminal SH2 domain, whereas other tyrosine residues like 342 and 346 in the linker region may contribute to the interaction with N-terminal SH2 domain (Moon et al, 2005). The main role of PI3K in phagocytosis appears to be the regulation of pseudopod extension necessary for particle internalization and may also regulate phagocytosis through activation of ERK (Garcia-Garcia & Rosales. 2002).
R-HSA-2029445 (Reactome) FCGR mediated phagocytosis requires CDC42 to stimulate actin polymerization, generating the force for phagocytic cup protrusion or pseudopod extension. CDC42 activation is restricted at the advancing edge of the phagocytic cup, where actin is concentrated, and is deactivated at the base of the phagocytic cup (Beemiller et al 2010). The mechanism behind the recruitment and activation of CDC42 during FCGR phagocytosis is unknown. VAV regulates the activation of RAC1 but not CDC42 and the GEF responsible for CDC42 activation during FCGR-mediated phagocytosis remains unidentified (Adam et al 2004, Patel et al 2002).
R-HSA-2029449 (Reactome) Multiple sites of phosphorylation are known to exist in SYK, which both regulate its activity and also serve as docking sites for other proteins. Some of these sites include Y131 of interdomain A, Y323, Y348, and Y352 of interdomain B, and Y525 and Y526 within the activation loop of the kinase domain and Y630 in the C-terminus (Zhang et al. 2002, Lupher et al. 1998, Furlong et al. 1997). Phosphorylation of these tyrosine residues disrupts autoinhibitory interactions and results in kinase activation even in the absence of phosphorylated ITAM tyrosines (Tsang et al. 2008). SYK is primarily phosphorylated by Src family kinases and this acts as an initiating trigger by generating few molecules of activated SYK which are then involved in major SYK autophosphorylation (Hillal et al. 1997).
R-HSA-2029451 (Reactome) The organized movements of membranes and the actin cytoskeleton are coordinated in phagocytosis by small GTPases of the Rho family. Specifically, RAC1 and CDC42 are known to be stimulated upon engagement of FCGR and are essential for the extension of the pseudopods that surround and engulf the phagocytic particle (Scott et al 2005). RAC1 is known to regulate actin dynamics. It is active throughout the phagocytic cup and activated RAC1 is necessary to assemble F actin. However, closing the phagocytic cup requires RAC1 to be deactivated (Naakaya et al 2007). Deletion of RAC1 prevents FCGR mediated phagocytosis (Hall et al 2006). RAC1 activation involves transition from an inactive GDP bound to an active GTP bound state catalysed by guanine exchanges factors (GEFs). VAV has been implicated in the activation of RAC1 (Patel et al 2002).
R-HSA-2029452 (Reactome) SYK is a tyrosine kinase related to ZAP70 that is expressed in all hematopoietic cells and coimmunoprecipitates with the gamma chain associated with FCGRIIIA in macrophages and with FCERI in mast cells. SYK is very important for FCGR phagocytosis and is recruited to these phosphorylated ITAM residues through its two SRC homology 2 (SH2) domains (Agarwal et al. 1993). When SYK kinase expression is inhibited with antisense oligonucleotides both in vitro and in vivo, phagocytosis and inflammation are abolished (Matsuda et al. 1997). The domain structure of SYK comprises a regulatory region at the N-terminus consisting of a pair of SH2 domains separated by an inter-SH2 linker called interdomain A, an SH2-domain-kinase linker termed interdomain B, and a C-terminal kinase domain (Arias-Palomo et al. 2009). In resting state SYK exists in an auto-inhibited conformation by the interactions between the SH2-SH2 regulatory region and the inter-SH2 linker and the catalytic domain. This interdomain interaction reduces the conformational flexibility required by the kinase domain for catalysis (Arias-Palomo et al. 2007). Changes in the orientation of the SH2 domains could control the disruption of the auto inhibitory interactions and the activation of SYK. These movements could be totally or partially induced by the binding to phosphorylated ITAMs and/or phosphorylation of tyrosine residues in interdomain A or B (Arias-Palomo et al. 2009). Tsang et al. suggested that SYK functions as an OR-gate switch with respect to phosphorylation and ITAM binding, as either one stimulus OR the other is sufficient to cause full activation (Tsang et al. 2008).
R-HSA-2029453 (Reactome) VAV proteins exist in an auto-inhibitory state folded in such a way as to inhibit the GEF activity of its DH domain. This folding is mediated through binding of tyrosines in the acidic domain to the DH domain and through binding of the CH domain to the C1 region. Activation of VAV may involve at least three different events to relieve this auto-inhibition. Phosphorylation of the tyrosines in the acidic domain causes them to be displaced from the DH domain, binding of a ligand to the CH domain may cause it to release the C1 domain and binding of PIP3 to PH domain may alter its conformation. VAV1 is phosphorylated on Y174 in the acidic domain, and this is mediated by Syk and Src-family tyrosine kinases. Once activated, VAV1 is then involved in the activation of RAC and CDC42 downstream of FCGR.
R-HSA-2029454 (Reactome) PAK1 needs autophosphorylation for complete activation. PAK1 is autophosphorylated at several sites, but S144 flanking the kinase inhibitor region and T423 within the catalytic domain are the two conserved sites that regulate the catalytic activity (Chong et al. 2001, Parrini et al. 2001).
R-HSA-2029455 (Reactome) FCGRI is coded by three different genes (A, B, and C) and is expressed on most myeloid cells including monocytes, macrophages and dendritic cells (Allen & Seed 1988). FCGRI is a high affinity IgG receptor capable of binding monomeric IgG. FCGRI exists as a complex containing ligand (IgG) binding extracellular alpha-chain and homodimer of signal transducing FcR gamma (CD3G) chains, or a heterodimer of signal transducing FcR gamma and zeta chains (Ernst et al. 1993, Scholl & Geha 1993, van Vugt et al. 1996). The cytoplasmic domain of FCGRI does not have signaling motifs, however it is suggested that the gamma-subunit might be required for generating the phagocytic signal (Duchemin et al. 1994, Indik et al. 1995).
The first step in Fc-gamma receptor (FCGR) phagocytosis is binding and clustering of FCGRs by IgG-coated foreign particles. FCGR are clustered at the cell surface by multivalent antigen-antibody complexes and recruited to lipid raft micro domains; monovalent ligand binding is insufficient to generate a signal. This cross-linking results in the localization of FCGRs into lipid rafts and this may aid in recruiting and complexing with additional signalling proteins associated with lipid rafts (Bournazos et al. 2009, Kwiatkowska & Sobota 2001, Kono et al. 2002). This is followed by phosphorylation of the tyrosine residues with in the immuno tyrosine activation motif (ITAM) located on the cytoplasmic portion of accessory gamma/zeta chains by membrane-associated tyrosine kinases of the Src family (Duchemin et al. 1994, van Vugt et al. 1996).
R-HSA-2029456 (Reactome) PAK1, a downstream effector of CDC42 and RAC1, is found localized in phagosomes. Upon activation, PAK1 phosphorylates LIMK, which directly phosphorylates and inactivates cofilin, a protein that mediates depolymerization of actin filaments. Thus, RAC and CDC42 coordinate actin dynamics by inducing actin polymerization via ARP2/3 on one hand, and inhibiting actin depolyerization via LIMK and cofilin on the other (Garcia-Garcia & Rosales 2002).
PAK1 exists as homodimer in a trans-inhibited conformation. The kinase inhibitory (KI) domain of one PAK1 molecule binds to the C-terminal catalytic domain of the other and inhibits catalytic activity. GTPases RAC1/CDC42 bind the GBD domain of PAK1 thereby altering the conformation of the KI domain, relieving inhibition of its catalytic domain, and allowing PAK1 autophosphorylation that is required for full kinase activity (Parrini et al. 2002, Zhao & Manser 2005).
R-HSA-2029457 (Reactome) FCGRIII (CD16) is a low affinity Fc gamma receptor and is encoded by two genes (A and B), the transmembrane form FCGRIIIA and the GPI anchored FCGRIIIB (Edberg et al. 1989). Between the two isoforms FCGRIIIA is involved in phagocytosis whereas FCGRIIIB is capable of inducing calcium signalling and actin polymerisation, but its role in phagocytosis is still not clear (Garcia Garcia & Rosales 2002). FCGRIIIA is expressed in macrophages and natural killer cells as a multi chain complex consisting of a single alpha chain containing IgG binding domains and a signal transducing gamma and/or zeta dimer (Wirthmuller et al. 1992, Lanier et al. 1989). Both gamma and zeta chains contain a conserved immunoreceptor tyrosine based activation motif (ITAM), which has 2 copies of the YXXL sequence (Isakov 1997). However, the gamma chain of FCGRIIIA is approximately sixfold more efficient in mediating phagocytosis than the zeta subunit (Park & Schreiber 1995). Phosphorylation of the conserved tyrosine residues of the ITAM in these accessory proteins is required for the phagocytic signal mediated by FCRGIIIA.
The first step in Fc-gamma receptor (FCGR) phagocytosis is binding and clustering of FCGRs by IgG-coated foreign particles. FCGR are clustered at the cell surface by multivalent antigen-antibody complexes and recruited to lipid raft micro domains; monovalent ligand binding is insufficient to generate a signal.
This cross linking results in the localisation of FCGRs into lipid rafts and this may aid in their recruiting and complexing with additional signalling proteins associated with lipid rafts (Kono et al. 2002). This is followed by phosphorylation of the tyrosine residues within the ITAM located on the cytoplasmic portion of accessory gamma/zeta chains by membrane associated tyrosine kinases of the Src family (Park et al. 1993).
R-HSA-2029458 (Reactome) VAV family members are cytoplasmic guanine nucleotide exchange factors (GEFs) for Rho-family GTPases (RAC, RHO and CDC42). VAV1 is found predominantly in hematopoietic cells, whereas VAV2 and VAV3 are more broadly expressed. VAV proteins link the cell surface receptors like FCGR to the intracellular Rho GTPases and the actin cytoskeleton during phagocytosis (Hall et al 2006). Experiments using two-hybrid system suggest that VAV1 with its SH2 domain directly binds to the phosphorylated Y342 of SYK (Deckert et al. 1996). VAV proteins are also recruited to membrane through their PH domain by binding PI(3,4,5)P3 produced by PI3K.
R-HSA-2029459 (Reactome) After cross linking, Fc gamma receptors are sequestered to lipid rafts where they are complexed with some of the tyrosine kinases of Src family and undergo phosphorylation on the tyrosine residues contained in conserved ITAM sequences. At least six out of nine members of the Src family kinases (SRC, FYN, FGR, HCK, YES and LYN ) have been identified in the phagocytic cells and are implicated in the initiation of Fc gamma mediated signaling. (Suzuki et al. 2000, Majeed et al. 2001, Kwiatkowska et al. 2003). Some of these kinases have been found associated with specific receptors. In monocytes HCK and LYN have been found associated with FCGRI (Durden et al. 1995), whereas only HCK with FCGRIIA (Ghazizadeh et al. 1994) while FGR in neutrophils (Hamada et al. 1993) and LCK in NK cells with FCGRIIIA (Pignata et al. 1993)
The implication of Src kinases in phosphorylation was first supported by pharmacological findings that herbimycin A, a tyrosine kinase inhibitor relatively specific for Src-family kinases, potently suppressed Fc receptor mediated functions (Greenberg et al. 1993, Suzuki et al. 2000). However, their particular involvement in phagocytosis remains unclear, as targeted disruption of single or multiple Src family genes did not result in significant alterations in phagocytosis (Hunter et al. 1993, Fitzer Attas et al. 2000, Suzuki et al. 2000). HCK, FGR and LYN triple-deficient (-/-) macrophages have shown significant delays in FCGR mediated phagocytosis, but these deficiencies do not completly disrupt the process (Fitzer Attas et al. 2000).
Tyrosine residues Y288 and Y304 (Y282 and Y298 according to the literature reference, it is 6 residues shorter compared to uniprot entry due to an alternate initiation codon usage), within ITAM sequence in the cytoplasmic domain of FCGRIIA are the key target sites that are phosphorylated by Src family kinases (Mitchell et al, 1994). In case of FCGRIA and FCGRIIIA the specific tyrosine residues within ITAMs of the associated gamma/zeta chains are phosphorylated by activated Src family kinases (SFKs) (Park et al. 1993).
R-HSA-2029460 (Reactome) LIM kinases are serine protein kinases with a unique combination of two N-terminal LIM motifs, a central PDZ domain, and a C-terminal protein kinase domain. LIMK1 is one of the downstream targets of PAK1 and is activated through phosphorylation by PAK1 on T508 within its activation loop (Edwards et al. 1999, Aizawa et al. 2001). LIM-kinase is responsible for the tight regulation of the activity of cofilin (a protein that depolymerizes actin filaments) and thus maintains the balance between actin assembly and disassembly. Phosphorylated cofilin is inactive, resulting in stabilization of the actin cytoskeleton.
R-HSA-2029465 (Reactome) WASP family verprolin-homologous proteins (WAVEs) function downstream of RAC1 and are involved in activation of the ARP2/3 complex. The resulting actin polymerization mediates the projection of the plasma membrane in lamellipodia and membrane ruffles. WAVEs exist as a pentameric hetero-complex called WAVE Regulatory Complex (WRC). The WRC consists of a WAVE family protein (WASF1, WASF2 or WASF3 - commonly known as WAVE1, WAVE2 or WAVE3), ABI (Abelson-interacting protein), NCKAP1 (NAP1, p125NAP1), CYFIP1 (SRA1) or the closely related CYFIP2 (PIR121), and BRK1 (HSPC300, BRICK). Of the three structurally conserved WAVEs in mammals, the importance of WAVE2 in activation of the ARP2/3 complex and the consequent formation of branched actin filaments is best established. WAVEs in the WRC are intrinsically inactive and are stimulated by RAC1 GTPase and phosphatidylinositols (PIP3). The C-terminal VCA domain of WAVE2 (and likely WAVE1 and WAVE3) which can bind both the ARP2/3 complex and actin monomers (G-actin) is masked in the inactive state. After PIP3 binds to the polybasic region of WAVE2 (and likely WAVE1 and WAVE3) and RAC1:GTP binds to the CYFIP1 (or CYFIP2) subunit of the WRC, allosteric changes most likely occur which allow WAVEs to interact with the ARP2/3 complex. The interactions between WAVEs and RAC1 are indirect. BAIAP2/IRSp53, an insulin receptor substrate, acts as a linker, binding both activated RAC1 and the proline-rich region of WAVE2 (and likely WAVE1 and WAVE3) and forming a trimolecular complex. CYFIP1 (or CYFIP2) in the WAVE regulatory complex binds directly to RAC1:GTP and links it to WAVE2 (and likely WAVE1 and WAVE3) (Derivery et al. 2009, Yamazaki et al. 2006, Takenawa & Suetsugu 2007, Chen et al. 2010, Pollard 2007, Lebensohn & Kirschner 2009).
R-HSA-2029466 (Reactome) Once activated, the ARP2/3 complex nucleates new actin filaments that extend from the sides of pre-existing mother actin filaments at a 70-degree angle to form Y-branched networks (Firat-Karalar & Welch 2010). These branched actin filaments push the cell membrane forward to form a pseudopod. The ARP2/3 complex is composed of two Arps (actin-related proteins), ARP2 and ARP3, and five unique proteins ARPC1, ARPC2, ARPC3, ARPC4 and ARPC5 (Gournier et al. 2001). Both ARP2 and ARP3 subunits bind ATP. There are two proposed models to explain the process of actin nucleation by ARP2/3 complex: the barbed-end branching model and the dendritic nucleation/side branching model (Le Clainche & Carlier 2008).
In barbed-end branching model, the branching/ternary complex (G-actin-WASP/WAVE-Arp2/3 complex) binds to the barbed end of the mother filament. G-actin bound to VCA domain or one of the Arp subunits incorporates into the mother filament at the barbed end, thus positioning ARP2/3 complex to initiate the daughter branch on the side of the mother filament. ARP2/3 nucleates the formation of new actin filament branches, which elongate at the barbed ends (Le Clainche & Carlier 2008, Pantaloni et al 2000, Le Clainche et al. 2003, Egile et al. 2005). In side branching model, the branching complex binds to the side of the mother actin filament mimicking an actin nucleus and initiates a lateral branch (Le Clainche & Carlier 2008, Amann & Pollard 2001).
R-HSA-2029467 (Reactome) RAC1 is activated from inactive GDP-bound state to active GTP-bound form by the GEF activity of DOCK180:ELMO complex.
R-HSA-2029468 (Reactome) Phosphatidic acid phosphatase (PAP) bound to the plasma membrane catalyzes the dephosphorylation of phosphatidic acid (PA), yielding diacylglycerol (DAG) and inorganic phosphate. In humans, Diacylglycerol pyrophosphate (DPPL1 and DPPL2) perform this reaction.
R-HSA-2029469 (Reactome) The ARP2/3 complex shows higher affinity for the phosphorylated VCA domain of WAVE2 than for the unphosphorylated VCA domain. WAVE proteins can be phosphorylated by various kinases. Active ERK (Mitogen activated protein kinase 3) phosphorylates the WAVE regulatory complex (WRC) on multiple serine/threonine sites within the proline-rich domains (PRDs) of WAVE2 and ABI1. Phosphorylation of the PRDs would disrupt their interaction with SH3 and PLP binding domains, potentially altering WRC activation. ERK phosphorylates both S343 and T346 in WAVE2 and S183, S216, S225, S392, and S410 in ABI1. Cumulatively, the phosphorylation of both WAVE2 and ABI in the WAVE regulatory complex (WRC) contributes to the RAC-induced WRC conformational change that exposes the VCA domain, leading to binding and activation of ARP2/3 (Mendoza et al. 2011, Nakanishi et al. 2007). ERK phosphorylation sites in WAVE2 are not strictly conserved in WAVE1 and WAVE3 but, based on the amino acid sequence, other potential ERK phosphorylation sites exist.
R-HSA-2029471 (Reactome) Phospholipase D (PLD) catalyses the hydrolysis of the membrane phospholipid, phosphatidylcholine (PC) to generate choline and metabolically active phosphatidic acid (PA) (Lennartz 1999). Pharmacological inhibition studies show that PLD participates in FCGR-mediated phagocytosis (Kusner et al. 1996). There is an increase in the activity of PLD following the activation of phagocytosis via FCGR (Kusner et al. 1999). Following activation of FCGR, PLD translocates to the plasma membrane at the phagocytic cup and generate PA. This PA can be converted to DAG through the action of phosphatidic acid phosphatase-1 (PAP-1). Thus activation of PLD may be an additional pathway leading to PKC activation.
The two isoforms PLD1 and PLD2 are both shown to be essential for the formation of phagosome at different stages. PLD1 is localized on the endosomal/lysosomal compartment and PLD2 is localized at the plasma membrane. PLD2 may be linked to phagosome formation whereas PLD1 may be involved in the focal exocytosis at the plasma membrane and also in the maturation process (Carrotte et al. 2006).
R-HSA-2029473 (Reactome) ATP bound G-actin monomers are added to the fast growing barbed ends of both mother and daughter filaments and the polymerization of these filaments drives membrane protrusion. In the process of phagocytosis, pseudopodia extend around the antibody-bound particle to form the phagocytic cup. This elongation continues until the filament reaches steady state equilibrium with free G-actin monomers (Millard et al. 2004, Le Clainche et al. 2008).
R-HSA-2029475 (Reactome) Several members of phospholipase A (PLA) are involved in phagocytosis. Macrophages express three classes of PLA2: secreted Ca-dependent (sPLA2), cytosolic Ca-dependent (cPLA2) and cytosolic Ca-independent (iPLA2) of which iPLA2 is involved in FCGR mediated arachidonic acid (AA) production. Aggregation of FCGR triggers phosphorylation and membrane translocation of iPLA2. Protein kinase C (PKC), ERK and p38MAPK seems to regulate iPLA2 in monocytes, neutrophils and macrophages. Phosphorylated iPLA2 then mediates production of AA and lysoophospholipids from phosphatidylcholine. iPLA2 inhibitors (bromoenol lactone) block AA release and phagocytosis which can be restored upon addition of exogenous AA, suggesting a critical role for iPLA2 in FCGR phagocytosis (Lennartz et al. 1993, Tay & Melendez). Release of AA by activated iPLA2 changes the physical characteristic of the membrane which may facilitate pseudopod extension.
R-HSA-2029476 (Reactome) In addition to the membrane remodeling for pseudopod extension, particle internalization requires a contractility force pulling the forming phagosome into the cytoplasm. Myosin motor proteins are the actin-binding proteins, with ATPase activity move along actin fibers, and produce the driving force for phagosome formation and transport. Several myosin motors including myosins IC, II, V, IXb are involved in FCGR-mediated phagocytosis as force generators and actin-based transport motors (Swanson et al. 1999). Nonmuscle myosin II, is a motor protein known to generate intracellular contractile forces and tension by associating with F-actin. It has been observed to localize around forming phagosomes and suggested a role in phagocytic-cup squeezing during FCGR-mediated phagocytosis. Each myosin II motor protein exists as a complex consisting of two copies each of myosin II heavy chain (MHC), essential light chains (ELC), and myosin regulatory light chain (MRLC). Selective inhibition of myosin II by ML-7, a myosin light-chain kinase (MLCK) inhibitor, prevents phagocytic cup closure, but not pseudopod extension for the formation of phagocytic cups in FCGR-mediated phagocytosis (Grooves et al. 2008, Araki 2006). Tight ring of actin filaments within the elongating pseudopodia squeezes the deformable particles. In the classical zipper model for phagocytosis, the pseudopod extends over the IgG-coated particles, in which FCGRs in the phagocyte plasma membrane interact sequentially with Fc portions of IgG molecules zippering the membrane along the particle. This sequential IgG-FCGR binding might not occur by itself, but requires forced zipper closure, where myosin-II contractile activity may promote the binding between the FCGR and its ligands, to facilitate the efficient extension and subsequent closure of phagocytic cups (Araki 2006, ). Myosin IC mediates the purse-string-like contraction that closes phagosomes. Myosin-V has been implicated in membrane trafficking events (Swanson et al. 1999).
R-HSA-2130194 (Reactome) Abelson interactor-1 (ABL) tyrosine kinase phosphorylates the strictly conserved tyrosine 150 in WAVE2 (Y151 in WAVE1 and WAVE3) (Leng et al. 2003, Chen et al. 2010).
R-HSA-2197690 (Reactome) After incorporation at the branch, the actin bound to VCA domain of WASP/WAVE undergoes ATP hydrolysis and this destabilizes its interaction with WASP/WAVE. This dissociates the branched junction from the membrane-bound WASP/WAVE (Kovar 2006).
R-HSA-2197691 (Reactome) WASP interacting proteins (WIP) family includes WIPF1 (WIP), WIPF2 (WIRE,WICH) and WIPF3 (CR16, corticosteroids and regional expression-16). WIPs share a specific proline rich sequence that interacts with the WH1 domain of WASP and N-WASP (WASL). WIPs form heterocomplexes with WASPs and may contribute to the WASP protein stability (Aspenstrom 2002, Kato et al. 2002, Ho et al. 2001, Moreau et al. 2000).
SH3 domain containing adaptor proteins like GRB2 (Carlier et al. 2000), NCK (Rohatgi et al. 2001) and WISH (DIP/SPIN90) (Fukuoka et al. 2001) bind to the proline rich domain in WASPs and activate the ARP2/3 complex. By binding simultaneously to N-WASP and the ARP2/3 complex, GRB2 works synergistically with CDC42 in the activation of ARP2/3 complex-mediated actin assembly (Carlier et al. 2000).
R-HSA-2197697 (Reactome) Macrophages lacking all the three isoforms of VAV did not affect FCGR-mediated phagocytosis suggesting that RAC1 is regulated by GEFs other than VAV downstream of the FCGR (Hall et al 2006). DOCK180, a member of GEFs, is found to be involved in the activation of RAC1. DOCK180 associates with the adaptor protein CRKII and the complex is found to accumulate at the phagocytic cup. DOCK180 is recruited to the sites of phagocytosis by binding to SH3 domain of CRKII through its proline-rich motif (Hasegawa et al 1996). CRKII is likely recruited to the activated FCGR complex by binding phosphorylated ITAM tyrosines on the receptor or through other phosphotyrosines on ancillary proteins that are recruited to the receptor complex (Lee et al 2007). Unlike the usual GEFs, DOCK180 does not contain the conserved Dbl homology (DH) domain. Instead, it has a DHR-2 or DOCKER domain capable of loading RAC with GTP (Brugnera et al 2002). Binding of DOCK180 to RAC alone is insufficient for GTP loading, and a DOCK180-ELMO interaction is required. ELMO1, as well as ELMO2, form a complex with DOCK180 and they function together as a bipartite GEF to optimally activate RAC (Gumienny et al 2001, Brugnera et al 2002).
R-HSA-2197698 (Reactome) WASP is phosphorylated on Tyr291 (Cory et al. 2002) and N-WASP (WASL) on Tyr256 (Wu et al. 2004) by Src family of tyrosine kinases and this phosphorylation may release the autoinhibitory intramolecular interactions. The phosphorylation seems to be enhanced by the activation of CDC42. WASP phosphorylation and binding of CDC42 have a synergistic effect on the activation of the ARP2/3 complex (Takenawa & Suetsugu 2007). In N-WASP, the phosphorylation may reduce its nuclear translocation and may sustain it in its functional site in the cytoplasm (Wu et al. 2004).
R-HSA-399950 (Reactome) The EPHB2-FAK pathway partially promotes dendritic spine stability through LIMK-mediated cofilin (CFL1) phosphorylation (Shi et al. 2009). CFL1 is a member of the ADF (actin-depolymerizing factor) protein family that is involved in regulating actin dynamics in the growth cone. It binds to actin in a one-to-one molar ratio, and stimulates both the severing of actin filaments and depolymerization of actin subunits from the actin filament end. Activated LIMK phosphorylates CFL1 on the conserved serine 3 residue located near the actin-binding site. After phosphorylation, CFL1 is inactive, loses its affinity for actin and dissociates from G-actin monomers. Once freed, ADP-actin monomers can exchange ADP with cytoplasmic ATP, ready for reincorporation at the barbed end of a growing filament (Gungabissoon & Bamburg 2003).
R-HSA-419644 (Reactome) Binding of Hsp90 to the LIMK proteins protects them from degradation and promotes their dimer formation and transphosphorylation. It is estimated that LIMK1 contains at least 5 phospho-amino acids primarily phospho-serines, in its kinase domain. The positions of these serine residues are not known. Transphosphorylation of these serine residues in LIMK1 increases its stability.
R-HSA-419645 (Reactome) After phosphorylation on Thr 508, LIMK undergoes homodimerization. Homodimer formation is promoted by the binding of heat shock protein 90 (Hsp90) to a short sequence in the kinase domain of LIMKs. LIMKs are further phosphorylated after homodimer formation and transphosphorylation of the kinase domain.
R-HSA-442586 (Reactome) Wiskott-Aldrich syndrome protein (WASP) and Neural-WASP (N-WASP, WASL) proteins are scaffolds that transduce signals from cell surface receptors to the activation of the ARP2/3 complex and actin polymerization. WASP and N-WASP possess a central GTPase binding domain (GBD) and an NH2-terminal WASP homology domain 1 (WH1) followed by a basic region (B), and a C-terminal VCA region that contains: a V domain (verprolin homology/WASP homology 2), a C domain (connecting), and an A motif (acidic). The VCA region is responsible for binding to and activating the ARP2/3 complex (Bompard & Caron 2004, Callebaut et al 1998). Under resting conditions, WASP and N-WASP are maintained in an autoinhibited state via interaction of the GBD and the VCA domains. This prevents access of the ARP2/3 complex and G-actin to the VCA region. Activated CDC42 binds to the GBD region of WASPs and this interaction releases the VCA region from autoinhibition, enabling binding of the ARP2/3 complex and stimulating actin polymerization (Kim et al 2000, Park & Cox 2009). Phosphoinositides (PtdIns(4,5)P2) interact with the basic (B) region in WASPs and this interaction is important for activation of the WASPs and the ARP2/3 complex (Higgs & Pollard 2000).
R-HSA-442592 (Reactome) Once WASPs (WASP and N-WASP) and WAVEs (WAVE2 and probably WAVE1 and WAVE3) are activated, their VCA region becomes available for binding to the ARP2/3 complex and actin monomer (G-actin). The actin monomer binds to the V domain and ARP2/3 complex binds to the CA domain. The simultaneous binding of G-actin and the ARP2/3 complex to the VCA region contributes to the activation of the ARP2/3-complex-mediated actin polymerization. The VCA module acts as a platform on which an actin monomer binds to the ARP2/3 complex to trigger actin polymerization (Takenawa & Suetsugu 2007).
RAC1/CDC42:PAK dimerArrowR-HSA-2029456 (Reactome)
RAC1/CDC42:PAK dimerR-HSA-2029454 (Reactome)
RAC1/CDC42:p-S144,T423-PAKArrowR-HSA-2029454 (Reactome)
RAC1:GDPR-HSA-2029451 (Reactome)
RAC1:GDPR-HSA-2029467 (Reactome)
RAC1:GTPArrowR-HSA-2029451 (Reactome)
RAC1:GTPArrowR-HSA-2029467 (Reactome)
RAC1:GTPR-HSA-2029465 (Reactome)
SH3 domain proteinsR-HSA-2197691 (Reactome)
SYKR-HSA-2029452 (Reactome)
Src family kinases (SFKs)mim-catalysisR-HSA-2029459 (Reactome)
Src-kinasesmim-catalysisR-HSA-2197698 (Reactome)
VAV1,2,3R-HSA-2029458 (Reactome)
WASP/N-WASPR-HSA-442586 (Reactome)
WAVE Regulatory ComplexR-HSA-2029465 (Reactome)
WIP family proteinsR-HSA-2197691 (Reactome)
WRC:IRSp53/58:RAC1:GTP:PIP3ArrowR-HSA-2029465 (Reactome)
WRC:IRSp53/58:RAC1:GTP:PIP3R-HSA-2130194 (Reactome)
cholineArrowR-HSA-2029471 (Reactome)
clustered IgG-Ag:FCGRsR-HSA-2029459 (Reactome)
clustered IgG-Ag:p-FCGRs:SYKArrowR-HSA-2029452 (Reactome)
clustered IgG-Ag:p-FCGRs:SYKR-HSA-2029449 (Reactome)
clustered IgG-Ag:p-FCGRs:SYKmim-catalysisR-HSA-2029449 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCGArrowR-HSA-2029270 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCGR-HSA-2029268 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCGmim-catalysisR-HSA-2029268 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAVArrowR-HSA-2029458 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAVR-HSA-2029453 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCGArrowR-HSA-2029268 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCGR-HSA-2029272 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-VAVArrowR-HSA-2029453 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-VAVmim-catalysisR-HSA-2029451 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYKArrowR-HSA-2029272 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYKArrowR-HSA-2029449 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYKR-HSA-2029270 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYKR-HSA-2029273 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYKR-HSA-2029458 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYKR-HSA-2197697 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYKmim-catalysisR-HSA-2029453 (Reactome)
clustered IgG-Ag:p-FCGRsArrowR-HSA-2029459 (Reactome)
clustered IgG-Ag:p-FCGRsArrowR-HSA-2029476 (Reactome)
clustered IgG-Ag:p-FCGRsR-HSA-2029452 (Reactome)
clustered IgG-Ag:p-FCGRsR-HSA-2029476 (Reactome)
p-4Y-PLCG1mim-catalysisR-HSA-167686 (Reactome)
p-PLCGArrowR-HSA-2029272 (Reactome)
p-S144,T423-PAK1ArrowR-HSA-2029454 (Reactome)
p-S144,T423-PAK1mim-catalysisR-HSA-2029460 (Reactome)
p-T,Y MAPK dimersmim-catalysisR-HSA-2029469 (Reactome)
p-T508-LIMK1ArrowR-HSA-2029460 (Reactome)
p-T508-LIMK1R-HSA-419645 (Reactome)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3ArrowR-HSA-2029469 (Reactome)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3ArrowR-HSA-2130194 (Reactome)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3R-HSA-2029469 (Reactome)
pCofilin: Active LIMK-1ArrowR-HSA-399950 (Reactome)
pLIMK dimer:HSP-90ArrowR-HSA-419645 (Reactome)
pLIMK dimer:HSP-90R-HSA-419644 (Reactome)
pLIMK dimer:HSP-90mim-catalysisR-HSA-419644 (Reactome)
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