Renin-angiotensin system (Rattus norvegicus)

From WikiPathways

Revision as of 02:21, 18 November 2015 by Mkutmon (Talk | contribs)
Jump to: navigation, search
& Renal damage& Induction of ApoptosisIPR3 isoformsVasodilation, InhibationHypersecration ofCell membraneCellular Proliferation,DNAPAK isoformsDNADNAof Cellular Proliferation Vasadiconstriction,DNAHypertrophy, fibrosisCell nucleusAldosterone, MyocardialJNK isoformsEndoplasmatic ReticulumCMA1PAK7IkbkbJak2ROSERK1ATF2STAT3MKK7AngiotensinogenSHCPtgIRRac1TYKAce2IP3PrkcqPI3KcAMPAceGrb2c-JunMapk9p38MKK4Ace2MEKK1NlnPYK2JNKCpa3PAK4EnpepFAKPAK2STAT1Angiotensin IIReninCA2+NOItpr3TYKDAGRasItpr2Angiotensin IIIMmeIP3RElk1Mapk3PKAMmePAKCeramideGalfaQ/11AceAC2/3Agtr2Angiotensin (1-9)Itpr1AcePAK6Thop1Angiotensin (1-7)PPtasePlcb1Mapk8Agtr1aMas1PpgbAngiotensin IVCTSGLnpepMEKK1IkbkgAnpepAngiotensin 1PAK3PIP2Mapk10SOSc-FosNF-KBRaf1Angiotensin (1-5)PAK136, 84, 1389, 14, 26, 40, 87...89, 13410, 307, 17, 47, 49, 61...71, 1153, 16, 43, 75, 100...63, 81308, 46, 14741, 1144, 28, 52, 54, 132...162, 1711, 44, 15283, 98, 11615, 20, 33, 57, 60...8924, 65, 94, 108, 125...50, 92, 104, 129, 135...15356, 867, 38, 48, 66, 96...79, 157, 17443, 122, 128, 137, 159...2, 7, 27, 35, 90...11, 25, 31, 34, 53...21, 62, 136114, 14115412, 59, 60, 82, 106...64, 88, 95935, 705, 581542315, 20, 33, 57, 60...39, 12625, 7619, 372, 7, 27, 35, 90...1542, 7, 27, 35, 90...55, 68, 1027, 38, 48, 66, 96...18, 69, 72, 73, 111...29, 7825, 9745, 80, 10513, 110, 175556, 32, 42, 51, 113...


Description

This pathway is based on the KEGG pathway of renin-angiotensin and the Ambion pathway of renin-angiotensin

The different colors used in the pathway stand for:

  • Darkblue: gene product.
  • Green: protein.
  • Red: metabolite.
  • Lightblue: protein which occurs in the human, but we don't know if this protein also occurs in the rat.

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

View all...
  1. Rafiq K, Kolpakov MA, Abdelfettah M, Streblow DN, Hassid A, Dell'Italia LJ, Sabri A; ''Role of protein-tyrosine phosphatase SHP2 in focal adhesion kinase down-regulation during neutrophil cathepsin G-induced cardiomyocytes anoikis.''; J Biol Chem, 2006 PubMed Europe PMC Scholia
  2. Paliege A, Pasumarthy A, Mizel D, Yang T, Schnermann J, Bachmann S; ''Effect of apocynin treatment on renal expression of COX-2, NOS1, and renin in Wistar-Kyoto and spontaneously hypertensive rats.''; Am J Physiol Regul Integr Comp Physiol, 2006 PubMed Europe PMC Scholia
  3. Bouallegue A, Daou GB, Srivastava AK; ''Nitric oxide attenuates endothelin-1-induced activation of ERK1/2, PKB, and Pyk2 in vascular smooth muscle cells by a cGMP-dependent pathway.''; Am J Physiol Heart Circ Physiol, 2007 PubMed Europe PMC Scholia
  4. Deng Y, Rapp JP; ''Cosegregation of blood pressure with angiotensin converting enzyme and atrial natriuretic peptide receptor genes using Dahl salt-sensitive rats.''; Nat Genet, 1992 PubMed Europe PMC Scholia
  5. Chappell MC, Gomez MN, Pirro NT, Ferrario CM; ''Release of angiotensin-(1-7) from the rat hindlimb: influence of angiotensin-converting enzyme inhibition.''; Hypertension, 2000 PubMed Europe PMC Scholia
  6. Ronchi FA, Irigoyen MC, Casarini DE; ''Association of somatic and N-domain angiotensin-converting enzymes from Wistar rat tissue with renal dysfunction in diabetes mellitus.''; J Renin Angiotensin Aldosterone Syst, 2007 PubMed Europe PMC Scholia
  7. Reudelhuber TL; ''A place in our hearts for the lowly angiotensin 1-7 peptide?''; Hypertension, 2006 PubMed Europe PMC Scholia
  8. Kramar EA, Armstrong DL, Ikeda S, Wayner MJ, Harding JW, Wright JW; ''The effects of angiotensin IV analogs on long-term potentiation within the CA1 region of the hippocampus in vitro.''; Brain Res, 2001 PubMed Europe PMC Scholia
  9. Ide H, Itoh H, Tomita M, Murakumo Y, Kobayashi T, Maruyama H, Osada Y, Nawa Y; ''Cloning of the cDNA encoding a novel rat mast-cell proteinase, rMCP-3, and its expression in comparison with other rat mast-cell proteinases.''; Biochem J, 1995 PubMed Europe PMC Scholia
  10. Nguyen G; ''Renin/prorenin receptors.''; Kidney Int, 2006 PubMed Europe PMC Scholia
  11. Kwitek AE, Gullings-Handley J, Yu J, Carlos DC, Orlebeke K, Nie J, Eckert J, Lemke A, Andrae JW, Bromberg S, Pasko D, Chen D, Scheetz TE, Casavant TL, Soares MB, Sheffield VC, Tonellato PJ, Jacob HJ; ''High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence.''; Genome Res, 2004 PubMed Europe PMC Scholia
  12. Dennehy KM, Kerstan A, Bischof A, Park JH, Na SY, Hunig T; ''Mitogenic signals through CD28 activate the protein kinase Ctheta-NF-kappaB pathway in primary peripheral T cells.''; Int Immunol, 2003 PubMed Europe PMC Scholia
  13. Kobayashi S, Ohnishi J, Nibu Y, Nishimatsu S, Umemura S, Ishii M, Murakami K, Miyazaki H; ''Cloning of the rat angiotensin II type 2 receptor gene and identification of its functional promoter region.''; Biochim Biophys Acta, 1995 PubMed Europe PMC Scholia
  14. Crackower MA, Sarao R, Oudit GY, Yagil C, Kozieradzki I, Scanga SE, Oliveira-dos-Santos AJ, da Costa J, Zhang L, Pei Y, Scholey J, Ferrario CM, Manoukian AS, Chappell MC, Backx PH, Yagil Y, Penninger JM; ''Angiotensin-converting enzyme 2 is an essential regulator of heart function.''; Nature, 2002 PubMed Europe PMC Scholia
  15. Cerezo-Guisado MI, Alvarez-Barrientos A, Argent R, Garcia-Marin LJ, Bragado MJ, Lorenzo MJ; ''c-Jun N-terminal protein kinase signalling pathway mediates lovastatin-induced rat brain neuroblast apoptosis.''; Biochim Biophys Acta, 2007 PubMed Europe PMC Scholia
  16. Wang YX, Ding YJ, Zhu YZ, Shi Y, Yao T, Zhu YC; ''Role of PKC in the novel synergistic action of urotensin II and angiotensin II and in urotensin II-induced vasoconstriction.''; Am J Physiol Heart Circ Physiol, 2007 PubMed Europe PMC Scholia
  17. Fernando RN, Larm J, Albiston AL, Chai SY; ''Distribution and cellular localization of insulin-regulated aminopeptidase in the rat central nervous system.''; J Comp Neurol, 2005 PubMed Europe PMC Scholia
  18. Kyriakis JM, Banerjee P, Nikolakaki E, Dai T, Rubie EA, Ahmad MF, Avruch J, Woodgett JR; ''The stress-activated protein kinase subfamily of c-Jun kinases.''; Nature, 1994 PubMed Europe PMC Scholia
  19. Ahmed MM, Arif M, Chikuma T, Kato T; ''Pentylenetetrazol-induced seizures affect the levels of prolyl oligopeptidase, thimet oligopeptidase and glial proteins in rat brain regions, and attenuation by MK-801 pretreatment.''; Neurochem Int, 2005 PubMed Europe PMC Scholia
  20. Towler P, Staker B, Prasad SG, Menon S, Tang J, Parsons T, Ryan D, Fisher M, Williams D, Dales NA, Patane MA, Pantoliano MW; ''ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
  21. Martinelli I, Mainini E, Mazzi C; ''Effect of 5-hydroxytryptophan on the secretion of PRL, GH, TSH and cortisol in obesity''; Minerva Endocrinol, 1992 PubMed Europe PMC Scholia
  22. Palm F, Connors SG, Mendonca M, Welch WJ, Wilcox CS; ''Angiotensin II type 2 receptors and nitric oxide sustain oxygenation in the clipped kidney of early Goldblatt hypertensive rats.''; Hypertension, 2008 PubMed Europe PMC Scholia
  23. Uematsu F, Takahashi M, Yoshida M, Igarashi M, Nakae D; ''Methylation of neutral endopeptidase 24.11 promoter in rat hepatocellular carcinoma.''; Cancer Sci, 2006 PubMed Europe PMC Scholia
  24. Ansar S, Vikman P, Nielsen M, Edvinsson L; ''Cerebrovascular ETB, 5-HT1B, and AT1 receptor upregulation correlates with reduction in regional CBF after subarachnoid hemorrhage.''; Am J Physiol Heart Circ Physiol, 2007 PubMed Europe PMC Scholia
  25. Rider L, Shatrova A, Feener EP, Webb L, Diakonova M; ''JAK2 tyrosine kinase phosphorylates PAK1 and regulates PAK1 activity and functions.''; J Biol Chem, 2007 PubMed Europe PMC Scholia
  26. Koike G, Winer ES, Horiuchi M, Brown DM, Szpirer C, Dzau VJ, Jacob HJ; ''Cloning, characterization, and genetic mapping of the rat type 2 angiotensin II receptor gene.''; Hypertension, 1995 PubMed Europe PMC Scholia
  27. Saito N, Courtois G, Chiba A, Yamamoto N, Nitta T, Hironaka N, Rowe M, Yamaoka S; ''Two carboxyl-terminal activation regions of Epstein-Barr virus latent membrane protein 1 activate NF-kappaB through distinct signaling pathways in fibroblast cell lines.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  28. Malfroy B, Kado-Fong H, Gros C, Giros B, Schwartz JC, Hellmiss R; ''Molecular cloning and amino acid sequence of rat kidney aminopeptidase M: a member of a super family of zinc-metallohydrolases.''; Biochem Biophys Res Commun, 1989 PubMed Europe PMC Scholia
  29. Sadjadi J, Kramer GL, Yu CH, Burress Welborn M 3rd, Chappell MC, Gregory Modrall J; ''Angiotensin converting enzyme-independent angiotensin ii production by chymase is up-regulated in the ischemic kidney in renovascular hypertension.''; J Surg Res, 2005 PubMed Europe PMC Scholia
  30. Waetzig V, Herdegen T; ''MEKK1 controls neurite regrowth after experimental injury by balancing ERK1/2 and JNK2 signaling.''; Mol Cell Neurosci, 2005 PubMed Europe PMC Scholia
  31. Abdelmohsen K, Sauerbier E, Ale-Agha N, Beier J, Walter P, Galban S, Stuhlmann D, Sies H, Klotz LO; ''Epidermal growth factor- and stress-induced loss of gap junctional communication is mediated by ERK-1/ERK-2 but not ERK-5 in rat liver epithelial cells.''; Biochem Biophys Res Commun, 2007 PubMed Europe PMC Scholia
  32. Padia SH, Kemp BA, Howell NL, Fournie-Zaluski MC, Roques BP, Carey RM; ''Conversion of renal angiotensin II to angiotensin III is critical for AT2 receptor-mediated natriuresis in rats.''; Hypertension, 2008 PubMed Europe PMC Scholia
  33. Polk WW, Ellis ME, Kushleika JV, Simmonds PL, Woods JS; ''RhoA regulation of NF-kappaB activation is mediated by COX-2-dependent feedback inhibition of IKK in kidney epithelial cells.''; Am J Physiol Cell Physiol, 2007 PubMed Europe PMC Scholia
  34. Takeda Y, Zhu A, Yoneda T, Usukura M, Takata H, Yamagishi M; ''Effects of aldosterone and angiotensin II receptor blockade on cardiac angiotensinogen and angiotensin-converting enzyme 2 expression in Dahl salt-sensitive hypertensive rats.''; Am J Hypertens, 2007 PubMed Europe PMC Scholia
  35. Haworth RS, Roberts NA, Cuello F, Avkiran M; ''Regulation of protein kinase D activity in adult myocardium: novel counter-regulatory roles for protein kinase Cepsilon and protein kinase A.''; J Mol Cell Cardiol, 2007 PubMed Europe PMC Scholia
  36. Fontan E, Traincard F, Levy SG, Yamaoka S, Veron M, Agou F; ''NEMO oligomerization in the dynamic assembly of the IkappaB kinase core complex.''; FEBS J, 2007 PubMed Europe PMC Scholia
  37. Brown CK, Madauss K, Lian W, Beck MR, Tolbert WD, Rodgers DW; ''Structure of neurolysin reveals a deep channel that limits substrate access.''; Proc Natl Acad Sci U S A, 2001 PubMed Europe PMC Scholia
  38. Leckie BJ; ''Targeting the renin-angiotensin system: what's new?''; Curr Med Chem Cardiovasc Hematol Agents, 2005 PubMed Europe PMC Scholia
  39. Augustyniak RA, Maliszewska-Scislo M, Chen H, Fallucca J, Rossi NF; ''Acute angiotensin-converting enzyme inhibition evokes bradykinin-induced sympathetic activation in diabetic rats.''; Am J Physiol Regul Integr Comp Physiol, 2007 PubMed Europe PMC Scholia
  40. Iwai N, Inagami T; ''Identification of two subtypes in the rat type I angiotensin II receptor.''; FEBS Lett, 1992 PubMed Europe PMC Scholia
  41. Ye MQ, Healy DP; ''Characterization of an angiotensin type-1 receptor partial cDNA from rat kidney: evidence for a novel AT1B receptor subtype.''; Biochem Biophys Res Commun, 1992 PubMed Europe PMC Scholia
  42. Vlahovic P, Cvetkovic T, Nikolic J, Sokolovic D; ''Ethanol inhibitory effect on rat kidney brush border aminopeptidases.''; Nephron Exp Nephrol, 2007 PubMed Europe PMC Scholia
  43. Kim JS, Jobin C; ''The flavonoid luteolin prevents lipopolysaccharide-induced NF-kappaB signalling and gene expression by blocking IkappaB kinase activity in intestinal epithelial cells and bone-marrow derived dendritic cells.''; Immunology, 2005 PubMed Europe PMC Scholia
  44. Wang SF, Liang Q, Li GW, Gao K; ''Gene expression profile in rat small intestinal allografts after cold preservation/reperfusion.''; World J Gastroenterol, 2005 PubMed Europe PMC Scholia
  45. Liao H, Keller SR, Castle JD; ''Insulin-regulated aminopeptidase marks an antigen-stimulated recycling compartment in mast cells.''; Traffic, 2006 PubMed Europe PMC Scholia
  46. Brosnihan KB, Neves LA, Joyner J, Averill DB, Chappell MC, Sarao R, Penninger J, Ferrario CM; ''Enhanced renal immunocytochemical expression of ANG-(1-7) and ACE2 during pregnancy.''; Hypertension, 2003 PubMed Europe PMC Scholia
  47. Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA; ''Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.''; Proc Natl Acad Sci U S A, 2002 PubMed Europe PMC Scholia
  48. Zhao ZS, Manser E; ''PAK family kinases: Physiological roles and regulation.''; Cell Logist, 2012 PubMed Europe PMC Scholia
  49. Schmid C, Ghirlanda-Keller C, Gosteli-Peter M; ''Ascorbic acid decreases neutral endopeptidase activity in cultured osteoblastic cells.''; Regul Pept, 2005 PubMed Europe PMC Scholia
  50. Cieslak D, Lazou A; ''Regulation of BAD protein by PKA, PKCdelta and phosphatases in adult rat cardiac myocytes subjected to oxidative stress.''; Mol Cells, 2007 PubMed Europe PMC Scholia
  51. Norman MU, Reeve SB, Dive V, Smith AI, Lew RA; ''Endopeptidases 3.4.24.15 and 24.16 in endothelial cells: potential role in vasoactive peptide metabolism.''; Am J Physiol Heart Circ Physiol, 2003 PubMed Europe PMC Scholia
  52. Li CH, Wang RM, Zhang QG, Zhang GY; ''Activated mitogen-activated protein kinase kinase 7 redistributes to the cytosol and binds to Jun N-terminal kinase-interacting protein 1 involving oxidative stress during early reperfusion in rat hippocampal CA1 region.''; J Neurochem, 2005 PubMed Europe PMC Scholia
  53. Fu YC, Yin SC, Chi CS, Hwang B, Hsu SL; ''Norepinephrine induces apoptosis in neonatal rat endothelial cells via a ROS-dependent JNK activation pathway.''; Apoptosis, 2006 PubMed Europe PMC Scholia
  54. Rettig R, Healy DP, Printz MP; ''Cardiovascular effects of microinjections of angiotensin II into the nucleus tractus solitarii.''; Brain Res, 1986 PubMed Europe PMC Scholia
  55. Inagami T, Iwai N, Sasaki K, Yamano Y, Bardhan S, Chaki S, Guo DF, Furuta H, Ohyama K, Kambayashi Y; ''Cloning, expression and regulation of angiotensin II receptors.''; Eur Heart J, 1994 PubMed Europe PMC Scholia
  56. Poumarat JS, Houillier P, Rismondo C, Roques B, Lazar G, Paillard M, Blanchard A; ''The luminal membrane of rat thick limb expresses AT1 receptor and aminopeptidase activities.''; Kidney Int, 2002 PubMed Europe PMC Scholia
  57. Tronik D, Ekker M, Rougeon F; ''Structural analysis of 5'-flanking regions of rat, mouse and human renin genes reveals the presence of a transposable-like element in the two mouse genes.''; Gene, 1988 PubMed Europe PMC Scholia
  58. de Gortari P, Vargas MA, Martinez A, Garcia-Vazquez AI, Uribe RM, Chavez-Gutierrez L, Magdaleno V, Boileau G, Charli JL, Joseph-Bravo P; ''Stage-specific modulation of neprilysin and aminopeptidase N in the limbic system during kindling progression.''; J Mol Neurosci, 2007 PubMed Europe PMC Scholia
  59. Levrand S, Pesse B, Feihl F, Waeber B, Pacher P, Rolli J, Schaller MD, Liaudet L; ''Peroxynitrite is a potent inhibitor of NF-{kappa}B activation triggered by inflammatory stimuli in cardiac and endothelial cell lines.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
  60. Carini R, Alchera E, Baldanzi G, Piranda D, Splendore R, Grazia De Cesaris M, Caraceni P, Graziani A, Albano E; ''Role of p38 map kinase in glycine-induced hepatocyte resistance to hypoxic injury.''; J Hepatol, 2007 PubMed Europe PMC Scholia
  61. Troyanovskaya M, Song L, Jayaraman G, Healy DP; ''Expression of aminopeptidase A, an angiotensinase, in glomerular mesangial cells.''; Hypertension, 1996 PubMed Europe PMC Scholia
  62. Hodges RR, Rios JD, Vrouvlianis J, Ota I, Zoukhri D, Dartt DA; ''Roles of protein kinase C, Ca2+, Pyk2, and c-Src in agonist activation of rat lacrimal gland p42/p44 MAPK.''; Invest Ophthalmol Vis Sci, 2006 PubMed Europe PMC Scholia
  63. Trask AJ, Averill DB, Ganten D, Chappell MC, Ferrario CM; ''Primary role of angiotensin-converting enzyme-2 in cardiac production of angiotensin-(1-7) in transgenic Ren-2 hypertensive rats.''; Am J Physiol Heart Circ Physiol, 2007 PubMed Europe PMC Scholia
  64. Leskinen MJ, Heikkila HM, Speer MY, Hakala JK, Laine M, Kovanen PT, Lindstedt KA; ''Mast cell chymase induces smooth muscle cell apoptosis by disrupting NF-kappaB-mediated survival signaling.''; Exp Cell Res, 2006 PubMed Europe PMC Scholia
  65. Der Sarkissian S, Grobe JL, Yuan L, Narielwala DR, Walter GA, Katovich MJ, Raizada MK; ''Cardiac overexpression of angiotensin converting enzyme 2 protects the heart from ischemia-induced pathophysiology.''; Hypertension, 2008 PubMed Europe PMC Scholia
  66. Rogel A, Bromberg Y, Sperling O, Zoref-Shani E; ''The neuroprotective adenosine-activated signal transduction pathway involves activation of phospholipase C.''; Nucleosides Nucleotides Nucleic Acids, 2006 PubMed Europe PMC Scholia
  67. Bjork P, Ohlsson K; ''Purification and N-terminal amino-acid sequence analysis of rat polymorphonuclear leukocyte cathepsin G.''; Biol Chem Hoppe Seyler, 1990 PubMed Europe PMC Scholia
  68. Sanchez-Lopez E, Rodriguez-Vita J, Cartier C, Ruperez M, Esteban V, Carvajal G, Rodrigues-Diez R, Plaza JJ, Egido J, Ruiz-Ortega M; ''Inhibitory effect of interleukin-1beta on angiotensin II-induced connective tissue growth factor and type IV collagen production in cultured mesangial cells.''; Am J Physiol Renal Physiol, 2008 PubMed Europe PMC Scholia
  69. Aiello S, Cassis P, Cassis L, Tomasoni S, Benigni A, Pezzotta A, Cavinato RA, Cugini D, Azzollini N, Mister M, Longaretti L, Thomson AW, Remuzzi G, Noris M; ''DnIKK2-transfected dendritic cells induce a novel population of inducible nitric oxide synthase-expressing CD4+CD25- cells with tolerogenic properties.''; Transplantation, 2007 PubMed Europe PMC Scholia
  70. Sleat DE, Sohar I, Lackland H, Majercak J, Lobel P; ''Rat brain contains high levels of mannose-6-phosphorylated glycoproteins including lysosomal enzymes and palmitoyl-protein thioesterase, an enzyme implicated in infantile neuronal lipofuscinosis.''; J Biol Chem, 1996 PubMed Europe PMC Scholia
  71. Iwai N, Yamano Y, Chaki S, Konishi F, Bardhan S, Tibbetts C, Sasaki K, Hasegawa M, Matsuda Y, Inagami T; ''Rat angiotensin II receptor: cDNA sequence and regulation of the gene expression.''; Biochem Biophys Res Commun, 1991 PubMed Europe PMC Scholia
  72. Rafiq K, Hanscom M, Valerie K, Steinberg SF, Sabri A; ''Novel mode for neutrophil protease cathepsin G-mediated signaling: membrane shedding of epidermal growth factor is required for cardiomyocyte anoikis.''; Circ Res, 2008 PubMed Europe PMC Scholia
  73. Oliveira V, Garrido PA, Rodrigues CC, Colquhoun A, Castro LM, Almeida PC, Shida CS, Juliano MA, Juliano L, Camargo AC, Hyslop S, Roberts JL, Grum-Tokars V, Glucksman MJ, Ferro ES; ''Calcium modulates endopeptidase 24.15 (EC 3.4.24.15) membrane association, secondary structure and substrate specificity.''; FEBS J, 2005 PubMed Europe PMC Scholia
  74. Thoidis G, Kandror KV; ''A Glut4-vesicle marker protein, insulin-responsive aminopeptidase, is localized in a novel vesicular compartment in PC12 cells.''; Traffic, 2001 PubMed Europe PMC Scholia
  75. Herschkovitz A, Liu YF, Ilan E, Ronen D, Boura-Halfon S, Zick Y; ''Common inhibitory serine sites phosphorylated by IRS-1 kinases, triggered by insulin and inducers of insulin resistance.''; J Biol Chem, 2007 PubMed Europe PMC Scholia
  76. Ohkubo H, Nakayama K, Tanaka T, Nakanishi S; ''Tissue distribution of rat angiotensinogen mRNA and structural analysis of its heterogeneity.''; J Biol Chem, 1986 PubMed Europe PMC Scholia
  77. Tikellis C, Johnston CI, Forbes JM, Burns WC, Burrell LM, Risvanis J, Cooper ME; ''Characterization of renal angiotensin-converting enzyme 2 in diabetic nephropathy.''; Hypertension, 2003 PubMed Europe PMC Scholia
  78. Watt VM, Yip CC; ''Amino acid sequence deduced from a rat kidney cDNA suggests it encodes the Zn-peptidase aminopeptidase N.''; J Biol Chem, 1989 PubMed Europe PMC Scholia
  79. Veerappan A, Reid AC, Estephan R, O'Connor N, Thadani-Mulero M, Salazar-Rodriguez M, Levi R, Silver RB; ''Mast cell renin and a local renin-angiotensin system in the airway: role in bronchoconstriction.''; Proc Natl Acad Sci U S A, 2008 PubMed Europe PMC Scholia
  80. Kishi K, Jin D, Takai S, Muramatsu M, Katayama H, Tamai H, Miyazaki M; ''Role of chymase-dependent angiotensin II formation in monocrotaline-induced pulmonary hypertensive rats.''; Pediatr Res, 2006 PubMed Europe PMC Scholia
  81. Cai Y, Stafford LJ, Bryan BA, Mitchell D, Liu M; ''G-protein-activated phospholipase C-beta, new partners for cell polarity proteins Par3 and Par6.''; Oncogene, 2005 PubMed Europe PMC Scholia
  82. Zylka MJ, Dong X, Southwell AL, Anderson DJ; ''Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family.''; Proc Natl Acad Sci U S A, 2003 PubMed Europe PMC Scholia
  83. Jacob HJ, Lindpaintner K, Lincoln SE, Kusumi K, Bunker RK, Mao YP, Ganten D, Dzau VJ, Lander ES; ''Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat.''; Cell, 1991 PubMed Europe PMC Scholia
  84. Harris EL, Phelan EL, Thompson CM, Millar JA, Grigor MR; ''Heart mass and blood pressure have separate genetic determinants in the New Zealand genetically hypertensive (GH) rat.''; J Hypertens, 1995 PubMed Europe PMC Scholia
  85. Leskinen MJ, Lindstedt KA, Wang Y, Kovanen PT; ''Mast cell chymase induces smooth muscle cell apoptosis by a mechanism involving fibronectin degradation and disruption of focal adhesions.''; Arterioscler Thromb Vasc Biol, 2003 PubMed Europe PMC Scholia
  86. Mustonen H, Hietaranta A, Puolakkainen P, Kemppainen E, Paimela H, Kiviluoto T, Kivilaakso E; ''Ethanol induced NF-{kappa}B activation protects against cell injury in cultured rat gastric mucosal epithelium.''; Am J Physiol Gastrointest Liver Physiol, 2007 PubMed Europe PMC Scholia
  87. Keller SR, Scott HM, Mastick CC, Aebersold R, Lienhard GE; ''Cloning and characterization of a novel insulin-regulated membrane aminopeptidase from Glut4 vesicles.''; J Biol Chem, 1995 PubMed Europe PMC Scholia
  88. Kotlo K, Hughes DE, Herrera VL, Ruiz-Opazo N, Costa RH, Robey RB, Danziger RS; ''Functional polymorphism of the Anpep gene increases promoter activity in the Dahl salt-resistant rat.''; Hypertension, 2007 PubMed Europe PMC Scholia
  89. Guo Z, Jiang H, Xu X, Duan W, Mattson MP; ''Leptin-mediated cell survival signaling in hippocampal neurons mediated by JAK STAT3 and mitochondrial stabilization.''; J Biol Chem, 2008 PubMed Europe PMC Scholia
  90. Shi ST, Li YF; ''Interaction of signal transduction between angiotensin AT1 and AT2 receptor subtypes in rat senescent heart.''; Chin Med J (Engl), 2007 PubMed Europe PMC Scholia
  91. Manser E, Leung T, Salihuddin H, Zhao ZS, Lim L; ''A brain serine/threonine protein kinase activated by Cdc42 and Rac1.''; Nature, 1994 PubMed Europe PMC Scholia
  92. Stempelj M, Kedinger M, Augenlicht L, Klampfer L; ''Essential role of the JAK/STAT1 signaling pathway in the expression of inducible nitric-oxide synthase in intestinal epithelial cells and its regulation by butyrate.''; J Biol Chem, 2007 PubMed Europe PMC Scholia
  93. Tucker BJ, Mundy CA, Maciejewski AR, Printz MP, Ziegler MG, Pelayo JC, Blantz RC; ''Changes in glomerular hemodynamic response to angiotensin II after subacute renal denervation in rats.''; J Clin Invest, 1986 PubMed Europe PMC Scholia
  94. Huffman LC, Koch SE, Butler KL; ''Coronary effluent from a preconditioned heart activates the JAK-STAT pathway and induces cardioprotection in a donor heart.''; Am J Physiol Heart Circ Physiol, 2008 PubMed Europe PMC Scholia
  95. Houdali B, Nguyen V, Ammon HP, Haap M, Schechinger W, Machicao F, Rett K, Haring HU, Schleicher ED; ''Prolonged glucose infusion into conscious rats inhibits early steps in insulin signalling and induces translocation of GLUT4 and protein kinase C in skeletal muscle.''; Diabetologia, 2002 PubMed Europe PMC Scholia
  96. Jackson EK, Gillespie DG, Zhu C, Ren J, Zacharia LC, Mi Z; ''Alpha2-adrenoceptors enhance angiotensin II-induced renal vasoconstriction: role for NADPH oxidase and RhoA.''; Hypertension, 2008 PubMed Europe PMC Scholia
  97. Whaley-Connell A, Govindarajan G, Habibi J, Hayden MR, Cooper SA, Wei Y, Ma L, Qazi M, Link D, Karuparthi PR, Stump C, Ferrario C, Sowers JR; ''Angiotensin II-mediated oxidative stress promotes myocardial tissue remodeling in the transgenic (mRen2) 27 Ren2 rat.''; Am J Physiol Endocrinol Metab, 2007 PubMed Europe PMC Scholia
  98. Li W, Moore MJ, Vasilieva N, Sui J, Wong SK, Berne MA, Somasundaran M, Sullivan JL, Luzuriaga K, Greenough TC, Choe H, Farzan M; ''Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus.''; Nature, 2003 PubMed Europe PMC Scholia
  99. Cole KR, Kumar S, Trong HL, Woodbury RG, Walsh KA, Neurath H; ''Rat mast cell carboxypeptidase: amino acid sequence and evidence of enzyme activity within mast cell granules.''; Biochemistry, 1991 PubMed Europe PMC Scholia
  100. Serizawa A, Dando PM, Barrett AJ; ''Characterization of a mitochondrial metallopeptidase reveals neurolysin as a homologue of thimet oligopeptidase.''; J Biol Chem, 1995 PubMed Europe PMC Scholia
  101. Oya M, Mikami S, Mizuno R, Marumo K, Mukai M, Murai M; ''C-jun activation in acquired cystic kidney disease and renal cell carcinoma.''; J Urol, 2005 PubMed Europe PMC Scholia
  102. Bao JX, Zhang LF, Ma J; ''Angiotensinogen and AT1R expression in cerebral and femoral arteries during hindlimb unloading in rats.''; Aviat Space Environ Med, 2007 PubMed Europe PMC Scholia
  103. Kokkinos MI, Brown HJ, de Iongh RU; ''Focal adhesion kinase (FAK) expression and activation during lens development.''; Mol Vis, 2007 PubMed Europe PMC Scholia
  104. Neves LA, Stovall K, Joyner J, Valdes G, Gallagher PE, Ferrario CM, Merrill DC, Brosnihan KB; ''ACE2 and ANG-(1-7) in the rat uterus during early and late gestation.''; Am J Physiol Regul Integr Comp Physiol, 2008 PubMed Europe PMC Scholia
  105. Bertazolli-Filho R, Coca-Prados M, Haddad A, Laicine EM; ''Molecular analysis of neurolysin expression in the rat and bovine ciliary body.''; Curr Eye Res, 2007 PubMed Europe PMC Scholia
  106. Deng AY, Dene H, Rapp JP; ''Mapping of a quantitative trait locus for blood pressure on rat chromosome 2.''; J Clin Invest, 1994 PubMed Europe PMC Scholia
  107. Kambayashi Y, Bardhan S, Takahashi K, Tsuzuki S, Inui H, Hamakubo T, Inagami T; ''Molecular cloning of a novel angiotensin II receptor isoform involved in phosphotyrosine phosphatase inhibition.''; J Biol Chem, 1993 PubMed Europe PMC Scholia
  108. Rivera P, Ocaranza MP, Lavandero S, Jalil JE; ''Rho kinase activation and gene expression related to vascular remodeling in normotensive rats with high angiotensin I converting enzyme levels.''; Hypertension, 2007 PubMed Europe PMC Scholia
  109. Jiang Q, Gu Z, Zhang G; ''Activation, involvement and nuclear translocation of c-Jun N-terminal protein kinase 1 and 2 in glutamate-induced apoptosis in cultured rat cortical neurons.''; Brain Res, 2002 PubMed Europe PMC Scholia
  110. Zhou J, Hu G, Herring BP; ''Smooth muscle-specific genes are differentially sensitive to inhibition by Elk-1.''; Mol Cell Biol, 2005 PubMed Europe PMC Scholia
  111. Norman MU, Lew RA, Smith AI, Hickey MJ; ''Metalloendopeptidases EC 3.4.24.15/16 regulate bradykinin activity in the cerebral microvasculature.''; Am J Physiol Heart Circ Physiol, 2003 PubMed Europe PMC Scholia
  112. Inukai T, Osuka K, Takagi T, Usuda N, Yoshida J, Takayasu M; ''Activation of c-jun in the rat basilar artery after subarachnoid hemorrhage.''; Neurosci Lett, 2007 PubMed Europe PMC Scholia
  113. Karlson U, Pejler G, Tomasini-Johansson B, Hellman L; ''Extended substrate specificity of rat mast cell protease 5, a rodent alpha-chymase with elastase-like primary specificity.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  114. Banes-Berceli AK, Ketsawatsomkron P, Ogbi S, Patel B, Pollock DM, Marrero MB; ''Angiotensin II and endothelin-1 augment the vascular complications of diabetes via JAK2 activation.''; Am J Physiol Heart Circ Physiol, 2007 PubMed Europe PMC Scholia
  115. Funkhouser JD, Tangada SD, Jones M, O SJ, Peterson RD; ''p146 type II alveolar epithelial cell antigen is identical to aminopeptidase N.''; Am J Physiol, 1991 PubMed Europe PMC Scholia
  116. Bateman RC Jr, Jackson D, Slaughter CA, Unnithan S, Chai YG, Moomaw C, Hersh LB; ''Identification of the active-site arginine in rat neutral endopeptidase 24.11 (enkephalinase) as arginine 102 and analysis of a glutamine 102 mutant.''; J Biol Chem, 1989 PubMed Europe PMC Scholia
  117. Fraga-Silva RA, Pinheiro SV, Goncalves AC, Alenina N, Bader M, Santos RA; ''The antithrombotic effect of angiotensin-(1-7) involves mas-mediated NO release from platelets.''; Mol Med, 2008 PubMed Europe PMC Scholia
  118. Lee HJ, Tomioka M, Takaki Y, Masumoto H, Saido TC; ''Molecular cloning and expression of aminopeptidase A isoforms from rat hippocampus.''; Biochim Biophys Acta, 2000 PubMed Europe PMC Scholia
  119. Nadruz W Jr, Kobarg CB, Kobarg J, Franchini KG; ''c-Jun is regulated by combination of enhanced expression and phosphorylation in acute-overloaded rat heart.''; Am J Physiol Heart Circ Physiol, 2004 PubMed Europe PMC Scholia
  120. Siragy HM, Inagami T, Carey RM; ''NO and cGMP mediate angiotensin AT2 receptor-induced renal renin inhibition in young rats.''; Am J Physiol Regul Integr Comp Physiol, 2007 PubMed Europe PMC Scholia
  121. Chaturvedi LS, Marsh HM, Shang X, Zheng Y, Basson MD; ''Repetitive deformation activates focal adhesion kinase and ERK mitogenic signals in human Caco-2 intestinal epithelial cells through Src and Rac1.''; J Biol Chem, 2007 PubMed Europe PMC Scholia
  122. Ray K, Hines CS, Rodgers DW; ''Mapping sequence differences between thimet oligopeptidase and neurolysin implicates key residues in substrate recognition.''; Protein Sci, 2002 PubMed Europe PMC Scholia
  123. McCool S, Pierotti AR; ''Expression of the thimet oligopeptidase gene is regulated by positively and negatively acting elements.''; DNA Cell Biol, 2000 PubMed Europe PMC Scholia
  124. Herath CB, Warner FJ, Lubel JS, Dean RG, Jia Z, Lew RA, Smith AI, Burrell LM, Angus PW; ''Upregulation of hepatic angiotensin-converting enzyme 2 (ACE2) and angiotensin-(1-7) levels in experimental biliary fibrosis.''; J Hepatol, 2007 PubMed Europe PMC Scholia
  125. Heikkila HM, Lutti S, Leskinen MJ, Hakala JK, Kovanen PT, Lindstedt KA; ''Activated mast cells induce endothelial cell apoptosis by a combined action of chymase and tumor necrosis factor-alpha.''; Arterioscler Thromb Vasc Biol, 2008 PubMed Europe PMC Scholia
  126. Li C, Wang X, Vais H, Thompson CB, Foskett JK, White C; ''Apoptosis regulation by Bcl-x(L) modulation of mammalian inositol 1,4,5-trisphosphate receptor channel isoform gating.''; Proc Natl Acad Sci U S A, 2007 PubMed Europe PMC Scholia
  127. Fukamizu A, Nishi K, Cho T, Saitoh M, Nakayama K, Ohkubo H, Nakanishi S, Murakami K; ''Structure of the rat renin gene.''; J Mol Biol, 1988 PubMed Europe PMC Scholia
  128. Clement N, Glorian M, Raymondjean M, Andreani M, Limon I; ''PGE2 amplifies the effects of IL-1beta on vascular smooth muscle cell de-differentiation: a consequence of the versatility of PGE2 receptors 3 due to the emerging expression of adenylyl cyclase 8.''; J Cell Physiol, 2006 PubMed Europe PMC Scholia
  129. Hu MC, Wang YP, Mikhail A, Qiu WR, Tan TH; ''Murine p38-delta mitogen-activated protein kinase, a developmentally regulated protein kinase that is activated by stress and proinflammatory cytokines.''; J Biol Chem, 1999 PubMed Europe PMC Scholia
  130. Gao L, Wang W, Li H, Sumners C, Zucker IH; ''Effects of angiotensin type 2 receptor overexpression in the rostral ventrolateral medulla on blood pressure and urine excretion in normal rats.''; Hypertension, 2008 PubMed Europe PMC Scholia
  131. Tallant EA, Ferrario CM, Gallagher PE; ''Angiotensin-(1-7) inhibits growth of cardiac myocytes through activation of the mas receptor.''; Am J Physiol Heart Circ Physiol, 2005 PubMed Europe PMC Scholia
  132. Pilar Carrera M, Ramirez-Exposito MJ, Duenas B, Dolores Mayas M, Jesus Garcia M, De la Chica S, Cortes P, Ruiz-Sanjuan M, Martinez-Martos JM; ''Insulin-regulated aminopeptidase/placental leucil Aminopeptidase (IRAP/P-lAP) and angiotensin IV-forming activities are modified in serum of rats with breast cancer induced by N-methyl-nitrosourea.''; Anticancer Res, 2006 PubMed Europe PMC Scholia
  133. Gillis LD, Pendley DS, Funkhouser JD; ''The major APN transcript of the alveolar type II epithelial cell originates from a unique upstream promoter region.''; Biochim Biophys Acta, 1998 PubMed Europe PMC Scholia
  134. Ibarz G, Oiry C, Carnazzi E, Crespy P, Escrieut C, Fourmy D, Galleyrand JC, Gagne D, Martinez J; ''Cholecystokinin 1 receptor modulates the MEKK1-induced c-Jun trans-activation: structural requirements of the receptor.''; Br J Pharmacol, 2006 PubMed Europe PMC Scholia
  135. Kreutz R, Huebner N, Ganten D, Lindpaintner K; ''Genetic linkage of the ACE gene to plasma angiotensin-converting enzyme activity but not to blood pressure. A quantitative trait locus confers identical complex phenotypes in human and rat hypertension.''; Circulation, 1995 PubMed Europe PMC Scholia
  136. Russo A, Russo G, Peticca M, Pietropaolo C, Di Rosa M, Iuvone T; ''Inhibition of granuloma-associated angiogenesis by controlling mast cell mediator release: role of mast cell protease-5.''; Br J Pharmacol, 2005 PubMed Europe PMC Scholia
  137. Sundberg-Smith LJ, Doherty JT, Mack CP, Taylor JM; ''Adhesion stimulates direct PAK1/ERK2 association and leads to ERK-dependent PAK1 Thr212 phosphorylation.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
  138. Hobara N, Goda M, Yoshida N, Takatori S, Kitamura Y, Mio M, Kawasaki H; ''Angiotensin II type 2 receptors facilitate reinnervation of phenol-lesioned vascular calcitonin gene-related peptide-containing nerves in rat mesenteric arteries.''; Neuroscience, 2007 PubMed Europe PMC Scholia
  139. Murphy TJ, Alexander RW, Griendling KK, Runge MS, Bernstein KE; ''Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor.''; Nature, 1991 PubMed Europe PMC Scholia
  140. Butterfield L, Zentrich E, Beekman A, Heasley LE; ''Stress- and cell type-dependent regulation of transfected c-Jun N-terminal kinase and mitogen-activated protein kinase kinase isoforms.''; Biochem J, 1999 PubMed Europe PMC Scholia
  141. Deng AY, Rapp JP; ''Locus for the inducible, but not a constitutive, nitric oxide synthase cosegregates with blood pressure in the Dahl salt-sensitive rat.''; J Clin Invest, 1995 PubMed Europe PMC Scholia
  142. Tsai CT, Lai LP, Kuo KT, Hwang JJ, Hsieh CS, Hsu KL, Tseng CD, Tseng YZ, Chiang FT, Lin JL; ''Angiotensin II activates signal transducer and activators of transcription 3 via Rac1 in atrial myocytes and fibroblasts: implication for the therapeutic effect of statin in atrial structural remodeling.''; Circulation, 2008 PubMed Europe PMC Scholia
  143. Song L, Ye M, Troyanovskaya M, Wilk E, Wilk S, Healy DP; ''Rat kidney glutamyl aminopeptidase (aminopeptidase A): molecular identity and cellular localization.''; Am J Physiol, 1994 PubMed Europe PMC Scholia
  144. van den Brink OW, Delbridge LM, Pedrazzini T, Rosenfeldt FL, Pepe S; ''Augmented myocardial methionine-enkephalin in a murine model of cardiac angiotensin II-overexpression.''; J Renin Angiotensin Aldosterone Syst, 2007 PubMed Europe PMC Scholia
  145. Reudelhuber TL; ''The renin-angiotensin system: peptides and enzymes beyond angiotensin II.''; Curr Opin Nephrol Hypertens, 2005 PubMed Europe PMC Scholia
  146. Morrison LS, Pierotti AR; ''Thimet oligopeptidase expression is differentially regulated in neuroendocrine and spermatid cell lines by transcription factor binding to SRY (sex-determining region Y), CAAT and CREB (cAMP-response-element-binding protein) promoter consensus sequences.''; Biochem J, 2003 PubMed Europe PMC Scholia
  147. Jeske NA, Berg KA, Cousins JC, Ferro ES, Clarke WP, Glucksman MJ, Roberts JL; ''Modulation of bradykinin signaling by EP24.15 and EP24.16 in cultured trigeminal ganglia.''; J Neurochem, 2006 PubMed Europe PMC Scholia
  148. Healy DP, Printz MP; ''Angiotensinogen levels in the brain and cerebrospinal fluid of the genetically hypertensive rat.''; Hypertension, 1985 PubMed Europe PMC Scholia
  149. Zhang Y, Zhang H, Yuan X, Gu X; ''Differential effects of phenylalanine on Rac1, Cdc42, and RhoA expression and activity in cultured cortical neurons.''; Pediatr Res, 2007 PubMed Europe PMC Scholia
  150. Lutzelschwab C, Pejler G, Aveskogh M, Hellman L; ''Secretory granule proteases in rat mast cells. Cloning of 10 different serine proteases and a carboxypeptidase A from various rat mast cell populations.''; J Exp Med, 1997 PubMed Europe PMC Scholia
  151. Becker LK, Etelvino GM, Walther T, Santos RA, Campagnole-Santos MJ; ''Immunofluorescence localization of the receptor Mas in cardiovascular-related areas of the rat brain.''; Am J Physiol Heart Circ Physiol, 2007 PubMed Europe PMC Scholia
  152. Carrera MP, Ramirez-Exposito MJ, Valenzuela MT, Duenas B, Garcia MJ, Mayas MD, Martinez-Martos JM; ''Renin-angiotensin system-regulating aminopeptidase activities are modified in the pineal gland of rats with breast cancer induced by N-methyl-nitrosourea.''; Cancer Invest, 2006 PubMed Europe PMC Scholia
  153. Tada M, Fukamizu A, Seo MS, Takahashi S, Murakami K; ''Nucleotide sequence of rat renin cDNA.''; Nucleic Acids Res, 1988 PubMed Europe PMC Scholia
  154. Young D, O'Neill K, Jessell T, Wigler M; ''Characterization of the rat mas oncogene and its high-level expression in the hippocampus and cerebral cortex of rat brain.''; Proc Natl Acad Sci U S A, 1988 PubMed Europe PMC Scholia
  155. Cali JJ, Zwaagstra JC, Mons N, Cooper DM, Krupinski J; ''Type VIII adenylyl cyclase. A Ca2+/calmodulin-stimulated enzyme expressed in discrete regions of rat brain.''; J Biol Chem, 1994 PubMed Europe PMC Scholia
  156. Malfroy B, Schofield PR, Kuang WJ, Seeburg PH, Mason AJ, Henzel WJ; ''Molecular cloning and amino acid sequence of rat enkephalinase.''; Biochem Biophys Res Commun, 1987 PubMed Europe PMC Scholia
  157. Stragier B, Demaegdt H, De Bundel D, Smolders I, Sarre S, Vauquelin G, Ebinger G, Michotte Y, Vanderheyden P; ''Involvement of insulin-regulated aminopeptidase and/or aminopeptidase N in the angiotensin IV-induced effect on dopamine release in the striatum of the rat.''; Brain Res, 2007 PubMed Europe PMC Scholia
  158. Langford K, Frenzel K, Martin BM, Bernstein KE; ''The genomic organization of the rat AT1 angiotensin receptor.''; Biochem Biophys Res Commun, 1992 PubMed Europe PMC Scholia
  159. Dauch P, Vincent JP, Checler F; ''Molecular cloning and expression of rat brain endopeptidase 3.4.24.16.''; J Biol Chem, 1995 PubMed Europe PMC Scholia
  160. Hamilton TA, Handa RK, Harding JW, Wright JW; ''A role for the angiotensin IV/AT4 system in mediating natriuresis in the rat.''; Peptides, 2001 PubMed Europe PMC Scholia
  161. Zhang Y, Vogel WK, McCullar JS, Greenwood JA, Filtz TM; ''Phospholipase C-beta3 and -beta1 form homodimers, but not heterodimers, through catalytic and carboxyl-terminal domains.''; Mol Pharmacol, 2006 PubMed Europe PMC Scholia
  162. Zhang J, Anastasiadis PZ, Liu Y, Thompson EA, Fields AP; ''Protein kinase C (PKC) betaII induces cell invasion through a Ras/Mek-, PKC iota/Rac 1-dependent signaling pathway.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
  163. Kim SO, Irwin P, Katz S, Pelech SL; ''Expression of mitogen-activated protein kinase pathways during postnatal development of rat heart.''; J Cell Biochem, 1998 PubMed Europe PMC Scholia
  164. Ballard-Croft C, Locklar AC, Keith BJ, Mentzer RM Jr, Lasley RD; ''Oxidative stress and adenosine A1 receptor activation differentially modulate subcellular cardiomyocyte MAPKs.''; Am J Physiol Heart Circ Physiol, 2008 PubMed Europe PMC Scholia
  165. Burnham CE, Hawelu-Johnson CL, Frank BM, Lynch KR; ''Molecular cloning of rat renin cDNA and its gene.''; Proc Natl Acad Sci U S A, 1987 PubMed Europe PMC Scholia
  166. Ocaranza MP, Godoy I, Jalil JE, Varas M, Collantes P, Pinto M, Roman M, Ramirez C, Copaja M, Diaz-Araya G, Castro P, Lavandero S; ''Enalapril attenuates downregulation of Angiotensin-converting enzyme 2 in the late phase of ventricular dysfunction in myocardial infarcted rat.''; Hypertension, 2006 PubMed Europe PMC Scholia
  167. Seyfried J, Wullner U; ''Inhibition of thioredoxin reductase induces apoptosis in neuronal cell lines: role of glutathione and the MKK4/JNK pathway.''; Biochem Biophys Res Commun, 2007 PubMed Europe PMC Scholia
  168. McKie N, Dando PM, Rawlings ND, Barrett AJ; ''Thimet oligopeptidase: similarity to 'soluble angiotensin II-binding protein' and some corrections to the published amino acid sequence of the rat testis enzyme.''; Biochem J, 1993 PubMed Europe PMC Scholia
  169. Nakayama T, Nakajima T, Sokabe H; ''Comparative studies on angiotensins. II. Structure of rat angiotensin and its identification by DNS-method.''; Chem Pharm Bull (Tokyo), 1972 PubMed Europe PMC Scholia
  170. Laes JF, Ravoet M, Quan X, Van Vooren P, Szpirer J, Szpirer C; ''Improved radiation hybrid map of rat chromosome 2: colocalization of the genes encoding corticotropin-releasing hormone and IL6-receptor with quantitative trait loci regulating the inflammatory response.''; Cytogenet Cell Genet, 2001 PubMed Europe PMC Scholia
  171. Mecawi Ade S, Lepletier A, de Araujo IG, Olivares EL, Reis LC; ''Assessment of brain AT1-receptor on the nocturnal basal and angiotensin-induced thirst and sodium appetite in ovariectomised rats.''; J Renin Angiotensin Aldosterone Syst, 2007 PubMed Europe PMC Scholia
  172. Khurana A, Dey CS; ''Involvement of Elk-1 in L6E9 skeletal muscle differentiation.''; FEBS Lett, 2002 PubMed Europe PMC Scholia
  173. Mustafa SB, Castro R, Falck AJ, Petershack JA, Henson BM, Mendoza YM, Choudary A, Seidner SR; ''Protein kinase A and mitogen-activated protein kinase pathways mediate cAMP induction of alpha-epithelial Na+ channels (alpha-ENaC).''; J Cell Physiol, 2008 PubMed Europe PMC Scholia
  174. Mukoyama M, Nakajima M, Horiuchi M, Sasamura H, Pratt RE, Dzau VJ; ''Expression cloning of type 2 angiotensin II receptor reveals a unique class of seven-transmembrane receptors.''; J Biol Chem, 1993 PubMed Europe PMC Scholia
  175. Mastick CC, Aebersold R, Lienhard GE; ''Characterization of a major protein in GLUT4 vesicles. Concentration in the vesicles and insulin-stimulated translocation to the plasma membrane.''; J Biol Chem, 1994 PubMed Europe PMC Scholia
  176. Pierotti A, Dong KW, Glucksman MJ, Orlowski M, Roberts JL; ''Molecular cloning and primary structure of rat testes metalloendopeptidase EC 3.4.24.15.''; Biochemistry, 1990 PubMed Europe PMC Scholia
  177. Olson ER, Shamhart PE, Naugle JE, Meszaros JG; ''Angiotensin II-induced extracellular signal-regulated kinase 1/2 activation is mediated by protein kinase Cdelta and intracellular calcium in adult rat cardiac fibroblasts.''; Hypertension, 2008 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
116622view11:06, 9 May 2021EweitzModified title
107611view14:06, 24 October 2019DeSlAdded last missing ID.
107610view14:05, 24 October 2019DeSlUpdated secondary ChEBI ID, added missing IDs to some proteins+metabolites.
107543view19:06, 18 October 2019KhanspersModified description
107542view19:05, 18 October 2019Khanspersadditional cleanup, added legend
107541view18:27, 18 October 2019Khanspersupdated layout, added xrefs
107242view14:34, 17 September 2019MaintBotChEBI identifier normalization
106984view13:44, 17 September 2019MaintBotHMDB identifier normalization
105411view16:06, 7 August 2019DeSlModified description
105410view16:05, 7 August 2019DeSlChanged colours to WPs scheme.
105409view16:02, 7 August 2019DeSlConnected unconnected lines (to groups)
105288view11:40, 28 July 2019EgonwAdded some interaction typing and missing identifiers.
101984view21:12, 21 November 2018EgonwRemoved whitespace in PubMed identifiers.
89602view16:08, 19 September 2016AgustinGVOntology Term : 'renal hypertension' added !
89601view16:08, 19 September 2016AgustinGVOntology Term : 'hypertension' added !
89042view19:57, 18 August 2016AgustinGVUpdate available metabolites annotations
88865view17:22, 16 August 2016AgustinGVSpecify description
88864view17:21, 16 August 2016AgustinGVSpecify description
88863view17:17, 16 August 2016AgustinGVUpdate AGT
88862view17:07, 16 August 2016AgustinGVUpdate AGT as protein
88861view17:04, 16 August 2016AgustinGVUpdate AGT Gene ID
88860view16:24, 16 August 2016AgustinGVQuick edit to datanode annotation or property
83030view02:21, 18 November 2015Mkutmonfix issues in reference list
83029view02:07, 18 November 2015Mkutmonfix outdated identifiers
70120view19:23, 12 July 2013MaintBotupdated to 2013 schema
67626view11:35, 26 June 2013DdiglesOntology Term : 'renin-angiotensin cascade pathway' added !
41750view02:40, 2 March 2011MaintBotRemoved redundant pathway information and comments
34121view19:26, 9 December 2009MaintBotAutomatic update of empty xrefs
32412view17:06, 15 August 2009MaintBotFixed text labels
32069view13:36, 14 August 2009MaintBotFixed group labels
29243view07:40, 18 April 2009EveloSome annotations
21469view11:31, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:Renin - Angiotensin System]] moved to [[Pathway:WP376]]: Moved to stable identifier
15828view08:19, 5 June 2008Thomaschanged type of Reactive oxygen species (ROS) to metabolite
11563view07:25, 11 April 2008Thomas
11553view17:09, 10 April 2008MarkRenin - Angiotensin System
11548view10:17, 10 April 2008Thomas
11535view07:42, 8 April 2008Markrenin-angiontensin system
11500view09:42, 3 April 2008Thomasremoved special characters from literature references
11491view18:05, 2 April 2008ThomasModified description
11490view17:22, 2 April 2008Mark
11488view13:29, 2 April 2008ThomasReverted edits by [[Special:Contributions/Mark|Mark]] ([[User_talk:Mark|Talk]]); changed back to last version by [[User:Thomas|Thomas]]
11487view13:24, 2 April 2008MarkRenin - Angiotensin System
11486view11:09, 2 April 2008MarkModified description
11476view15:20, 1 April 2008Thomascosmetic changes
11475view15:16, 1 April 2008Thomaschanged green to darker shade (more easy to read)
11468view12:35, 1 April 2008Thomasfixed anchor links
11459view09:58, 1 April 2008RishiaachaibersingRenin - Angiotensin System
11458view08:35, 1 April 2008MarkRenin - Angiotensin System
11454view07:24, 1 April 2008Mark
11277view14:14, 26 March 2008MarkRenin - Angiotensin System

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AC2/3Protein2036 (RGD)
ATF2Protein81647 (Entrez Gene)
AceProtein2493 (RGD)
Ace2Protein728890 (RGD)
Agtr1aProtein2070 (RGD)
Agtr2Protein2072 (RGD)
Angiotensin (1-5)Metabolite
Angiotensin (1-7)Metabolite
Angiotensin (1-9)Metabolite
Angiotensin 1Metabolite
Angiotensin IIMetaboliteHMDB01035 (HMDB)
Angiotensin IIIMetaboliteHMDB01036 (HMDB)
Angiotensin IVMetaboliteHMDB01038 (HMDB)
AngiotensinogenGeneProduct2069 (RGD)
AnpepProtein2991 (RGD)
CA2+Metabolite
CMA1Protein2365 (RGD)
CTSGProtein1307681 (RGD)
CeramideMetabolite
Cpa3Protein2390 (RGD)
DAGMetabolite
ERK1Protein70500 (RGD)
Elk1Protein1598663 (RGD)
EnpepProtein621228 (RGD)
FAKProtein3443 (RGD)
GalfaQ/11Protein
Grb2Protein81504 (Entrez Gene)
IP3Metabolite
IP3RProtein
IkbkbProtein621375 (RGD)
IkbkgProteinENSRNOG00000060936 (Ensembl)
Itpr1Protein2933 (RGD)
Itpr2Protein69649 (RGD)
Itpr3Protein2934 (RGD)
JNKProtein
Jak2ProteinENSRNOG00000059968 (Ensembl)
LnpepProtein621752 (RGD)
MEKK1Protein620966 (RGD)
MKK4Protein1307040 (RGD)
MKK7Protein1560043 (RGD)
Mapk10Protein3663 (RGD)
Mapk3ProteinENSRNOG00000053583 (Ensembl)
Mapk8Protein621506 (RGD)
Mapk9Protein628847 (RGD)
Mas1Protein3049 (RGD)
MmeProtein3098 (RGD)
NF-KBProtein727889 (RGD)
NOMetabolite
NlnProtein621518 (RGD)
PAKProtein
PAK1Protein3250 (RGD)
PAK2Protein61953 (RGD)
PAK3Protein3251 (RGD)
PAK4Protein1307705 (RGD)
PAK6Protein1306213 (RGD)
PAK7Protein1312009 (RGD)
PI3KProtein
PIP2Metabolite
PKAProtein3389 (RGD)
PPtaseProtein62018 (RGD)
PYK2Protein628758 (RGD)
Plcb1Protein3344 (RGD)
PpgbProtein1309070 (RGD)
PrkcqProtein620968 (RGD)
PtgIRProtein292661 (Entrez Gene)
ROSMetabolite
Rac1Protein619755 (RGD)
Raf1Protein24703 (Entrez Gene)
RasProtein2981 (RGD)
ReninProtein3554 (RGD)
SHCProtein
SOSProtein
STAT1Protein3771 (RGD)
STAT3Protein3772 (RGD)
TYKProtein
Thop1Protein68330 (RGD)
c-FosProtein
c-JunProtein2943 (RGD)
cAMPMetabolite
p38Protein3045 (RGD)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP376"
Personal tools