Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)

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1-4endoplasmic reticulum lumenphagocytic cupcytosolIg heavy chain V-III region WAS IGLC7 Ig kappa chain V-IV region STH IGLC2 Ig kappa chain V-III region B6 IGHG2 Ig kappa chain V-II region RPMI 6410 Ig kappa chain V-III region POM Ig kappa chain V-II region MIL Ig heavy chain V-III region GAL IGLV4-60(1-?) Ig lambda chain V-IV region Kern IGHV(1-?) Ig lambda chain V-VI region SUT IGLV3-12(1-?) Ig kappa chain V-III region Ti Ig heavy chain V-III region KOL Ig kappa chain V-II region TEW CDC42:GTP:WASP/N-WASP:WIP:SH3 proteinsIg kappa chain V-I region Ni IGLV11-55(1-?) Ig lambda chain V-II region VIL Ig kappa chain V-I region EU Ig heavy chain V-III region TIL IGLC6 Ig kappa chain V-III region GOL Ig lambda chain V-II region TOG Ig heavy chain V-III region LAY Ig kappa chain V-III region VG ARP2/3 complex (ATPbound)Ig kappa chain V-I region WAT Ig kappa chain V-I region WAT IGLV2-18(1-?) Ig lambda chain V-II region TRO Ig kappa chain V-III region IARC/BL41 Ig kappa chain V-II region MIL LIMK1Ig kappa chain V-I region DEE Ig kappa chain V-III region GOL IGLV5-37(1-?) IGHG4 Ig heavy chain V-II region NEWM Ig lambda chain V-II region NEI Ig heavy chain V-III region KOL IGLV3-16(1-?) Ig kappa chain V-IV region Len Ig lambda chain V-II region VIL IGKC Ig kappa chain V region EV15 p-S144,T423-PAK1IGHG4 Ig heavy chain V-I region EU Ig heavy chain V-II region WAH CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteinsIg heavy chain V-III region CAM IGHV7-81(1-?) IGLV8-61(1-?) IGLV3-27(1-?) Ig heavy chain V-II region HE Ig kappa chain V-III region POM Ig lambda chain V-IV region Kern Ig kappa chain V-III region VG Ig kappa chain V-I region Daudi DAGsIg lambda chain V-I region NEWM IGHV7-81(1-?) IGLV1-40(1-?) IgH heavy chain V-III region VH26 precursor Ig kappa chain V-II region TEW Ig kappa chain V-I region Hau Ig lambda chain V-III region LOI GTPIGLV10-54(1-?) Ig kappa chain V-I region WEA Ig lambda chain V-II region NEI H2OIg kappa chain V-I region Hau Ig heavy chain V-III region WEA IGLV(23-?) Antigen Ig heavy chain V-I region WOL IGLC1 Ig kappa chain V-I region Mev Ig kappa chain V-I region Wes IGLC3 Ig lambda chain V region 4A IGHV7-81(1-?) Ig lambda chain V-VI region WLT Ig kappa chain V-I region BAN Ig heavy chain V-III region TUR Ig lambda chain V-I region NIG-64 Ig lambda chain V-II region VIL Ig heavy chain V-III region WEA Ig heavy chain V-III region JON Ig lambda chain V-IV region Bau Ig heavy chain V-III region TRO IGLV2-23(1-?) Ig kappa chain V-II region RPMI 6410 Ig lambda chain V-III region LOI Ig lambda chain V-IV region X IGLV2-11(1-?) Ig lambda chain V-II region WIN IGKV1-5(23-?) PI(3,4,5)P3Ig lambda chain V-I region NEW IGLV2-33(1-?) Ig kappa chain V-IV region B17 Ig heavy chain V-III region BRO Ig lambda chain V-I region HA Ig lambda chain V-VI region SUT p-Y288,Y304-FCGR2A Ig kappa chain V-III region VH Ig kappa chain V-III region SIE Ig lambda chain V-III region SH Ig lambda chain V-I region WAH PiIGHG1 Ig heavy chain V-I region SIE Ig lambda chain V-I region NEW Ig lambda chain V-VI region SUT IGHG1 Ig lambda chain V-II region TRO IGLV2-33(1-?) FCGR3A Ig heavy chain V-III region TIL Ig kappa chain V-III region B6 Ig kappa chain V-I region Rei IGLV7-43(1-?) ADPIg lambda chain V-VI region AR Ig lambda chain V-II region BO FCGR3A DAGsIg lambda chain V-I region VOR p-Y288,Y304-FCGR2A CDC42:GTP, RAC1:GTPIg heavy chain V-III region BUT Ig heavy chain V-I region SIE Ig kappa chain V-IV region B17 IGLV3-22(1-?) IGLV3-12(1-?) IGKC Ig heavy chain V-II region ARH-77 Ig kappa chain V-III region VH Ig lambda chain V-II region VIL Ig kappa chain V-I region Daudi IGKV1-5(23-?) Ig lambda chain V-I region NEWM Ig kappa chain V-III region POM Ig lambda chain V-I region HA IGLV8-61(1-?) PLDIGLV1-40(1-?) Ig kappa chain V-I region Lay Ig heavy chain V-II region WAH Actin filament boundMyosin-XIg kappa chain V-I region Scw BAIAP2Ig lambda chain V-II region WIN Ig heavy chain V-III region BUT IGLC2 IGLC6 Ig kappa chain V-IV region JI Ig heavy chain V-III region TUR IGLV3-16(1-?) IGLV3-16(1-?) IGHG1 IGHG1 FCGR3A Ig kappa chain V-I region AG p-Y160,Y171-CD3G Ig lambda chain V-I region EPS Ig heavy chain V-II region ARH-77 ADPIg heavy chain V-II region SESS Ig heavy chain V-III region NIE Ig lambda chain V-I region WAH Ig kappa chain V-I region Scw Ig lambda chain V-V region DEL Ig heavy chain V-II region MCE Ig heavy chain V-III region BUT Ig kappa chain V-I region WAT Ig heavy chain V-II region DAW Ig kappa chain V-I region Bi Active LIMK1Ig lambda chain V-IV region Kern p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3ADPIg heavy chain V-I region EU IGHG4 IGLV3-27(1-?) Ig heavy chain V-I region EU Ig kappa chain V-I region Kue IGHV7-81(1-?) Ig heavy chain V-III region CAM Ig heavy chain V-I region ND IGLV2-33(1-?) Ig heavy chain V-III region GA Ig lambda chain V-II region NIG-84 Ig heavy chain V-II region COR Ig lambda chain V-I region MEM Ig kappa chain V-I region EU IGLV3-22(1-?) p-Y288,Y304-FCGR2A IGLV1-40(1-?) IGLV5-45(1-?) Ig kappa chain V-II region GM607 Ig heavy chain V-III region TEI Ig heavy chain V-I region ND Ig lambda chain V-I region VOR Ig kappa chain V-IV region Len Ig lambda chain V-II region NIG-58 Ig lambda chain V-I region MEM IGLC3 Ig kappa chain V-IV region JI Ig kappa chain V-III region HAH Ig heavy chain V-III region WAS Ig kappa chain V-I region Walker IGLV3-25(1-?) Ig kappa chain V-I region Gal Ig lambda chain V-I region NEWM Ig kappa chain V-I region Ni Ig kappa chain V-III region HIC Ig heavy chain V-III region TIL Ig kappa chain V-I region CAR Ig heavy chain V-III region JON IGHG1 Ig lambda chain V-I region EPS Ig lambda chain V-II region BUR Ig lambda chain V-VI region EB4 Ig heavy chain V-III region CAM Ig lambda chain V-II region NIG-58 Ig kappa chain V-I region Bi IGLV2-18(1-?) IGLV3-12(1-?) Ig heavy chain V-II region HE Ig kappa chain V-II region Cum Ig lambda chain V-VI region SUT GDPIg kappa chain V-III region B6 PhosphatidylcholineIg kappa chain V-IV region B17 IGLV3-27(1-?) Ig kappa chain V-I region EU Ig kappa chain V-I region DEE Ig lambda chain V-I region BL2 Ig kappa chain V-I region Scw IGKV4-1(21-?) Ig lambda chain V-I region BL2 Ig kappa chain V-I region Wes 2-LysophosphatidylcholineIg kappa chain V-I region Walker IGLV3-12(1-?) Ig lambda chain V-I region MEM Ig heavy chain V-III region GA Ig heavy chain V-II region OU Ig heavy chain V-I region WOL Ig kappa chain V-I region Bi Ig kappa chain V-I region Rei Ig kappa chain V-III region NG9 Ig kappa chain V-III region VH Ig heavy chain V-II region DAW IGLV4-60(1-?) IGLV3-12(1-?) PiIGLV(23-?) IGHG4 Ig heavy chain V-I region ND Ig lambda chain V-IV region Hil IGLV2-23(1-?) Ig kappa chain V-I region Scw Ig heavy chain V-III region HIL Ig kappa chain V-III region CLL IGLV5-37(1-?) Ig lambda chain V-II region BUR IGKV1-5(23-?) Ig heavy chain V-I region SIE Ig kappa chain V-II region FR Ig kappa chain V-IV region STH Ig kappa chain V-II region TEW Ig heavy chain V-I region SIE Ig kappa chain V-I region BAN Ig kappa chain V-III region NG9 Ig lambda chain V-VI region WLT Ig heavy chain V-III region TUR Ig kappa chain V-I region Rei IgH heavy chain V-III region VH26 precursor Ig kappa chain V-III region NG9 IGLV2-23(1-?) IGLC2 CRK:DOCK180:ELMO1,ELMO2IGLV8-61(1-?) Ig kappa chain V-I region Ka IgH heavy chain V-III region VH26 precursor CD247-1 Ig heavy chain V-III region WAS Ig heavy chain V-III region TEI Ig heavy chain V-I region EU Ig lambda chain V-IV region Bau Ig kappa chain V-IV region JI ATPIg lambda chain V region 4A ATPIGLV1-40(1-?) Ig heavy chain V-III region NIE Ig kappa chain V-III region CLL IGLV4-69(1-?) Ig kappa chain V-III region POM Ig kappa chain V-I region AG Ig kappa chain V-IV region STH CD247-1 Ig lambda chain V region 4A IGLV3-27(1-?) Ig kappa chain V-I region Scw IgG-Ag:FCGRIA:CD3GhomodimerIg kappa chain V-IV region JI IGLC7 p-6Y-SYK Ig kappa chain V-III region Ti Ig lambda chain V-I region NEW ADPIg lambda chain V-II region NIG-84 p-Y172-VAV2 PAK1FCGR3A Ig lambda chain V-III region SH Ig kappa chain V-IV region B17 IGLV4-60(1-?) Ig heavy chain V-III region ZAP Ig lambda chain V-I region NEW IGLV5-37(1-?) Ig lambda chain V-VI region WLT ATPIg lambda chain V-I region NEWM Ig lambda chain V-II region BOH ADPIg kappa chain V-I region Ka Ig kappa chain V-I region OU Ig heavy chain V-II region COR IGKV4-1(21-?) IGLV2-33(1-?) Ig heavy chain V-III region ZAP Ig kappa chain V-III region VG IGHV7-81(1-?) Ig heavy chain V-III region KOL ATPIg kappa chain V-I region DEE IGLV3-27(1-?) Ig kappa chain V-I region AU Ig lambda chain V-IV region Hil IGLV1-40(1-?) IGLV3-12(1-?) Ig lambda chain V-III region LOI ARAIGLV5-45(1-?) IGLV1-36(1-?) Ig heavy chain V-III region DOB IGLV1-36(1-?) IgG-Ag:FCGRIIAIGHG2 Ig kappa chain V-I region Bi Ig heavy chain V-I region WOL MyosinIg kappa chain V-III region CLL Ig lambda chain V-II region BUR Ig lambda chain V-I region NIG-64 Ig lambda chain V-IV region X Ig kappa chain V-II region MIL SYKIg kappa chain V-I region Wes Ig kappa chain V-II region FR SH3 domain proteinsIg lambda chain V-I region HA p-Y160,Y171-CD3G IGLV2-23(1-?) Ig lambda chain V-I region NIG-64 Ig lambda chain V-VI region AR Ig kappa chain V-I region CAR Ig kappa chain V-I region Gal IGHV7-81(1-?) Ig lambda chain V-I region BL2 Ig kappa chain V-III region WOL Ig lambda chain V-I region HA Ig heavy chain V-II region NEWM Ig kappa chain V-III region HIC Ig kappa chain V-I region Daudi Ig lambda chain V-IV region X Ig heavy chain V-II region SESS Ig heavy chain V-I region WOL IGKVA18(21-?) Ig lambda chain V-I region MEM IGLV2-23(1-?) Ig heavy chain V-III region WAS cholineIg lambda chain V-IV region X Ig kappa chain V-III region HAH Ig kappa chain V-II region FR Ig lambda chain V-II region BOH Ig lambda chain V-VII region MOT Ig lambda chain V-III region LOI CD3G Ig lambda chain V-VI region WLT Ig kappa chain V-I region Rei Ig kappa chain V-II region MIL Ig lambda chain V-III region LOI Ig heavy chain V-II region NEWM Ig lambda chain V-I region NEW Ig kappa chain V-I region Scw Ig lambda chain V-I region WAH Ig kappa chain V-I region Wes Ig kappa chain V-II region TEW IGLV11-55(1-?) Ig heavy chain V-III region POM Ig kappa chain V-I region DEE IGLV1-44(1-?) Ig lambda chain V-II region BOH p-Y174-VAV1 IGLV3-16(1-?) Ig lambda chain V region 4A Ig kappa chain V-II region GM607 Ig lambda chain V-II region WIN IGKV1-5(23-?) Ig lambda chain V-II region TRO Ig kappa chain V-I region Wes CDC42:GTPIg heavy chain V-I region ND Ig heavy chain V-II region NEWM Ig kappa chain V-II region TEW IGLV(23-?) FCGR1A IGLV2-18(1-?) IGLV7-46(1-?) Ig kappa chain V-III region IARC/BL41 Ig kappa chain V-II region MIL Ig kappa chain V region EV15 Ig lambda chain V-IV region MOL IGLV2-33(1-?) Ig lambda chain V-II region MGC Ig heavy chain V-III region JON Ig kappa chain V-III region HAH Ig kappa chain V-I region Ni Ig kappa chain V-I region Roy Ig heavy chain V-III region ZAP Ig lambda chain V-II region BUR Ig kappa chain V-I region Gal Ig heavy chain V-II region SESS Ig heavy chain V-II region HE IGKC Ig kappa chain V-I region Mev Ig heavy chain V-III region BRO Ig lambda chain V-VI region NIG-48 Ig kappa chain V-II region Cum IGLV4-3(1-?) IGLV3-22(1-?) Ig kappa chain V-III region HAH Ig kappa chain V-I region Rei Ig kappa chain V-III region B6 Ig kappa chain V-III region HIC Ig heavy chain V-I region Mot FCGR3A Ig heavy chain V-II region WAH Ig kappa chain V-I region Ni IGLV4-69(1-?) Ig kappa chain V-I region CAR Ig lambda chain V-VI region NIG-48 Ig kappa chain V-IV region STH Ig heavy chain V-II region MCE Ig heavy chain V-III region WEA Ig lambda chain V-IV region Bau Ig kappa chain V-I region CAR IGLV7-46(1-?) Ig heavy chain V-II region OU Ig lambda chain V-III region LOI IGKVA18(21-?) Ig lambda chain V-I region NIG-64 Ig lambda chain V-III region LOI Ig heavy chain V-III region BUT Ig heavy chain V-III region ZAP IGHG4 Ig kappa chain V-IV region STH Ig kappa chain V-I region Walker Ig lambda chain V-V region DEL IGLV2-11(1-?) Ig kappa chain V-I region OU Ig kappa chain V-I region Walker Ig heavy chain V-III region KOL Ig kappa chain V-IV region B17 IGKVA18(21-?) Ig kappa chain V-III region Ti Ig heavy chain V-III region WEA IGHG3 Ig heavy chain V-I region EU Ig kappa chain V-I region WEA Ig heavy chain V-I region Mot IGLC6 Ig kappa chain V-II region TEW Ig kappa chain V-III region SIE Ig kappa chain V region EV15 Ig heavy chain V-III region ZAP Ig kappa chain V-I region Mev Ig kappa chain V-III region HIC Ig lambda chain V-II region NIG-84 IGLV4-69(1-?) IGHG3 Ig heavy chain V-II region WAH Ig lambda chain V-I region MEM Ig kappa chain V-IV region JI Ig lambda chain V-VI region AR IGHG2 Ig heavy chain V-II region DAW Ig lambda chain V-II region NIG-58 Ca2+Ig lambda chain V-II region MGC Ig kappa chain V-III region VH Ig lambda chain V-I region BL2 Ig kappa chain V-I region Daudi IGLV(23-?) Ig kappa chain V-II region MIL IGLC7 Ig lambda chain V-II region TRO Ig heavy chain V-II region WAH Ig heavy chain V-III region WEA Ig heavy chain V-II region DAW Ig kappa chain V-III region IARC/BL41 Ig heavy chain V-II region COR Ig heavy chain V-II region MCE IGLV2-23(1-?) Ig heavy chain V-II region NEWM Ig lambda chain V-V region DEL Ig lambda chain V-I region EPS IGLC1 Ig kappa chain V-II region MIL Ig lambda chain V-II region BO Ig heavy chain V-II region MCE Ig kappa chain V-I region Hau Ig heavy chain V-II region WAH Ig heavy chain V-III region BRO Antigen-antibodycomplexIg kappa chain V-II region FR Ig kappa chain V-III region NG9 p-4Y-PLCG1IGHG3 Ig lambda chain V region 4A Ig lambda chain V-VI region AR Ig kappa chain V-IV region B17 Ig lambda chain V-II region TRO Myosin-ActinfilamentsIg lambda chain V-II region MGC IGLV(23-?) Ig lambda chain V-VI region NIG-48 ATPATPIg kappa chain V-I region WAT Ig kappa chain V-III region VG Ig kappa chain V-II region RPMI 6410 IGLC1 Ig heavy chain V-III region NIE clusteredIgG-Ag:p-FCGRs:p-6Y-SYKIg kappa chain V-I region Roy RAC1:GTPIg kappa chain V-III region GOL Antigen Ig kappa chain V-I region Kue IGKC Antigen Ig heavy chain V-III region TIL IGHV7-81(1-?) IGLC1 Phospho-PKC-delta/epsilonIg kappa chain V-I region CAR IGLC7 Ig heavy chain V-III region LAY Ig lambda chain V-II region VIL Ig kappa chain V-I region Bi Ig kappa chain V-IV region STH Ig kappa chain V-III region VG Ig kappa chain V-I region Roy Ig lambda chain V-III region LOI Ig lambda chain V-II region NEI IGLV7-46(1-?) Ig lambda chain V-VI region WLT Ig heavy chain V-III region TUR IGHV(1-?) Ig heavy chain V-III region WEA Ig kappa chain V-I region Ka Ig kappa chain V-II region RPMI 6410 IGLV2-11(1-?) WRC:IRSp53/58:RAC1:GTP:PIP3IGLV5-45(1-?) Ig heavy chain V-III region GA Ig lambda chain V-V region DEL Ig kappa chain V-I region OU Ig lambda chain V-II region TOG Ig lambda chain V-I region VOR Ig heavy chain V-I region HG3 SYK IGLV3-16(1-?) Ig kappa chain V-I region Daudi Ig heavy chain V-I region WOL p-6Y-CD247-1 Ig kappa chain V-I region Bi Ig lambda chain V-II region NIG-58 Ig lambda chain V-II region TOG clusteredIgG-Ag:p-FCGRs:p-6Y-SYK:p-VAVIGKC Ig kappa chain V-I region Walker Ig kappa chain V-I region Kue Ig kappa chain V-IV region Len Ig lambda chain V-VI region EB4 Ig heavy chain V-III region POM Ig lambda chain V-IV region Kern Ig lambda chain V-I region NEWM Ig heavy chain V-III region TRO Ig kappa chain V-I region DEE Ig kappa chain V-I region WAT Ig lambda chain V-IV region Hil IGLC2 Ig heavy chain V-II region DAW IGLV2-11(1-?) Ig kappa chain V-I region Walker Ig heavy chain V-I region EU Ig kappa chain V-I region Ka IGLV7-46(1-?) Ig kappa chain V-I region AU Ig heavy chain V-III region BRO IGLV4-3(1-?) p-Y160,Y171-CD3G Ig lambda chain V-III region SH Ig lambda chain V-III region SH Ig kappa chain V-I region Roy Ig kappa chain V-I region BAN Ig heavy chain V-III region HIL Myosin-X dimerIGLC1 Ig kappa chain V-I region AG IGLC6 Ig kappa chain V-I region BAN Ig kappa chain V region EV15 IGLV3-22(1-?) clusteredIgG-Ag:p-FCGRs:SYKIg kappa chain V-III region B6 PAK1 dimerIg heavy chain V-III region CAM p-Y288,Y304-FCGR2A IGLV8-61(1-?) IGLV3-12(1-?) Ig kappa chain V-III region NG9 Ig heavy chain V-I region HG3 Ig kappa chain V-I region Bi Ig lambda chain V-I region NIG-64 Ig lambda chain V-II region TOG Ig heavy chain V-II region SESS Ig lambda chain V-III region SH Ig kappa chain V-III region WOL IGLV8-61(1-?) p-Y160,Y171-CD3G Ig heavy chain V-I region HG3 Ig heavy chain V-III region POM Ig kappa chain V-III region SIE Ig heavy chain V-II region HE PI(3,4,5)P3PCIg kappa chain V-I region AU Ig kappa chain V-I region HK101 Ig lambda chain V-II region BOH Ig heavy chain V-II region HE Ig lambda chain V-I region EPS Antigen Ig heavy chain V-II region HE IGLC7 IGLC2 p-T508-LIMK1Ig kappa chain V-I region Rei Ig lambda chain V-III region SH IGLV2-23(1-?) Ig lambda chain V-I region NEW Ig lambda chain V-VI region EB4 Ig lambda chain V-V region DEL Ig kappa chain V-I region AG Ig lambda chain V-II region TOG IGLV3-22(1-?) IGLV1-44(1-?) IGHV(1-?) Ig heavy chain V-II region MCE Ig kappa chain V-I region Hau IGLV7-43(1-?) Ig kappa chain V region EV15 IGHG3 IGLV8-61(1-?) Ig lambda chain V-II region BOH Ig lambda chain V-I region WAH Ig lambda chain V-I region EPS Ig kappa chain V-III region WOL Ig kappa chain V-III region CLL IGLV1-40(1-?) Ig kappa chain V-I region Ka Ig kappa chain V-II region FR Ig kappa chain V-I region HK101 Ig heavy chain V-III region HIL IGLV7-43(1-?) Ig kappa chain V-III region VG Ig kappa chain V-I region Gal Ig heavy chain V-I region SIE IGLV4-60(1-?) IGHV(1-?) Ig heavy chain V-III region POM Ig kappa chain V-III region Ti Ig heavy chain V-II region ARH-77 Ig lambda chain V-VI region SUT Ig kappa chain V-IV region Len IGLV7-43(1-?) Ig kappa chain V-II region GM607 Ig heavy chain V-III region DOB Ig kappa chain V-I region Bi Ig kappa chain V-IV region B17 IGLV(23-?) IGLV11-55(1-?) FCGR1A IGLV1-36(1-?) Ig lambda chain V-VI region EB4 Ig kappa chain V-I region WAT Ig lambda chain V-VI region NIG-48 Ig lambda chain V-II region BO Ig heavy chain V-I region ND Ig heavy chain V-III region BUR Ig lambda chain V-II region NEI IGLV3-25(1-?) Ig kappa chain V-I region BAN Ig heavy chain V-III region KOL FCGR3A Ig heavy chain V-III region JON Ig heavy chain V-III region BUT Ig kappa chain V-I region BAN Ig kappa chain V-II region Cum Ig lambda chain V-II region NIG-58 Ig lambda chain V-I region MEM IGLV5-37(1-?) Ig heavy chain V-I region SIE Ig kappa chain V-IV region Len Ig lambda chain V-VII region MOT Ig lambda chain V-I region EPS Ig lambda chain V-II region TOG Ig kappa chain V-II region TEW IGHG4 IGLV1-36(1-?) IGLV3-16(1-?) Ig lambda chain V-I region NIG-64 Ig kappa chain V-I region AG Ig kappa chain V-I region OU Ig heavy chain V-II region NEWM Ig lambda chain V-II region BUR PAADPIg lambda chain V-I region EPS VAV2 Ig kappa chain V-I region Hau Ig kappa chain V-I region WEA Ig heavy chain V-I region ND Ig lambda chain V-IV region Bau Ig heavy chain V-I region EU Ig lambda chain V-VII region MOT IGHG2 Ig lambda chain V-II region BOH Ig lambda chain V-II region WIN IGLV1-36(1-?) FCGR1A Ig lambda chain V-II region BOH Ig heavy chain V-III region ZAP Ig heavy chain V-II region OU p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3PI(3,4,5)P3 IGKV1-5(23-?) Ig heavy chain V-II region SESS Ig lambda chain V-IV region Hil Ig lambda chain V region 4A Ig lambda chain V-I region WAH G-actinIGLV2-33(1-?) Ig heavy chain V-III region BUT Ig heavy chain V-III region TEI VAV3 Ig kappa chain V-III region WOL IGLV5-45(1-?) IGHG3 Ig heavy chain V-III region DOB Ig kappa chain V-III region WOL Ig heavy chain V-I region WOL clusteredIgG-Ag:p-FCGRsIg kappa chain V-I region Mev IGLC3 Ig heavy chain V-III region DOB IGLC7 Ig lambda chain V-II region NIG-58 IGLV7-43(1-?) Ig heavy chain V-III region BRO Ig heavy chain V-II region MCE Ig kappa chain V-I region Ni IGLV5-37(1-?) Ig lambda chain V-IV region X Ig lambda chain V-IV region MOL Ig heavy chain V-III region ZAP Ig kappa chain V-I region HK101 Ig lambda chain V-VI region AR IGLV1-36(1-?) Ig lambda chain V-II region NIG-58 IGLV7-46(1-?) Ig lambda chain V-II region BO Ig lambda chain V-V region DEL Ig lambda chain V-I region HA Ig heavy chain V-II region HE Ig lambda chain V-II region TRO Ig heavy chain V-III region BUR Ig heavy chain V-III region CAM Ig kappa chain V-III region HIC IGLV1-36(1-?) Ig kappa chain V-I region Gal Ig heavy chain V-III region TUR Ig kappa chain V-I region Rei p-Y288,Y304-FCGR2A Ig lambda chain V-VI region EB4 Ig lambda chain V-I region VOR Ig heavy chain V-III region GAL Ig heavy chain V-III region LAY Ig lambda chain V-VII region MOT Ig heavy chain V-II region OU IGLV10-54(1-?) Ig kappa chain V-I region AU IGLV(23-?) Ig lambda chain V-VI region NIG-48 IGLV4-60(1-?) FCGR3A Ig kappa chain V-I region EU Ig kappa chain V-III region VH Ig kappa chain V-I region CAR ADPIg kappa chain V-II region GM607 Ig kappa chain V-I region OU AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramerIg heavy chain V-III region NIE Ig kappa chain V-I region BAN Ig heavy chain V-II region WAH IGLV4-3(1-?) FCGR3A Ig lambda chain V-VII region MOT IGHG3 IGLC7 clusteredIgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCGIg kappa chain V-I region CAR Ig heavy chain V-III region LAY IGLV5-37(1-?) IGLV3-25(1-?) Antigen Ig kappa chain V-I region Wes Ig heavy chain V-III region WEA Ig kappa chain V-III region GOL Ig lambda chain V-II region MGC Ig kappa chain V-I region OU Ig heavy chain V-I region WOL Ig heavy chain V-II region SESS Ig lambda chain V-VI region SUT IGLV10-54(1-?) Ig heavy chain V-III region LAY Ig heavy chain V-III region HIL PI3KIg kappa chain V-III region Ti IGLV7-43(1-?) Ig kappa chain V-II region FR Ig kappa chain V-I region Scw Ig lambda chain V-IV region X Ig kappa chain V-I region AG IGLV1-44(1-?) Ig kappa chain V-III region VG Ig kappa chain V-III region NG9 Ig kappa chain V-I region Scw Ig heavy chain V-III region ZAP Ig heavy chain V-II region ARH-77 PI(3,4,5)P3Ig lambda chain V-IV region Bau IgH heavy chain V-III region VH26 precursor Ig kappa chain V-II region MIL Ig heavy chain V-III region TIL Ig lambda chain V-VI region AR IGLV3-27(1-?) Ig heavy chain V-III region HIL Ig lambda chain V-II region TRO Ig kappa chain V-I region Daudi IGLV4-69(1-?) Ig lambda chain V-II region VIL ADPIg lambda chain V-IV region Kern Ig heavy chain V-II region SESS IGKV1-5(23-?) Ig kappa chain V-III region HAH Ig lambda chain V-III region SH Ig kappa chain V-I region Wes Ig heavy chain V-III region BRO Ig kappa chain V-II region Cum Ig heavy chain V-I region SIE Ig lambda chain V-II region MGC IGLV1-36(1-?) Ig kappa chain V-I region EU Ig kappa chain V-I region CAR Ig lambda chain V-II region BUR IGLV2-23(1-?) Ig lambda chain V-II region VIL Ig kappa chain V-I region Kue IGLV4-3(1-?) Ig lambda chain V-IV region Bau p-PLCGIg kappa chain V-I region Gal Ig lambda chain V-II region TOG IGLV4-60(1-?) Ig kappa chain V-III region POM Ig lambda chain V-I region NEW Ig heavy chain V-I region HG3 IGLV2-18(1-?) Ig lambda chain V-IV region Bau IGKV4-1(21-?) Ig heavy chain V-I region WOL Ig heavy chain V-I region EU Ig kappa chain V-I region OU Ig kappa chain V-I region Ni Ig heavy chain V-III region WAS Ig heavy chain V-III region BUT Ig kappa chain V-III region IARC/BL41 IGHV7-81(1-?) Ig kappa chain V-III region HIC Ig lambda chain V-II region BUR Src family kinases(SFKs)ATPIGHG3 VAV2 Ig heavy chain V-III region TUR IGLV2-11(1-?) Ig kappa chain V-III region GOL Ig kappa chain V-II region Cum Ig kappa chain V-II region FR Ig heavy chain V-III region TRO Ig kappa chain V-I region AU Ig lambda chain V-IV region Kern Ig kappa chain V-III region NG9 PI(4,5)P2Ig heavy chain V-II region DAW Ig kappa chain V-IV region B17 Ig lambda chain V-VI region WLT Ig lambda chain V-VI region NIG-48 Ig lambda chain V-VI region AR FCGR3A Ig lambda chain V-IV region Kern IGLV4-69(1-?) IGLV10-54(1-?) Ig heavy chain V-III region HIL PLC gamma1,2Ig kappa chain V-I region HK101 Ig lambda chain V-VI region NIG-48 IGLV1-36(1-?) ADPIg kappa chain V region EV15 ATPIGLC2 IGKV4-1(21-?) Ig lambda chain V-II region WIN IGLV2-18(1-?) IGLV4-69(1-?) Antigen IGLV2-23(1-?) PI(3,4)P2Ig kappa chain V-I region OU IGLC2 Ig lambda chain V-VI region WLT Ig kappa chain V-III region HAH clusteredIgG-Ag:p-FCGRsIg kappa chain V-I region OU Ig kappa chain V-III region VH Ig kappa chain V-I region Gal PLA2G6Ig kappa chain V-III region Ti IGLV4-3(1-?) IGLV8-61(1-?) Ig kappa chain V-II region FR Ig lambda chain V-I region BL2 IGLC1 Ig heavy chain V-I region Mot FCGRIIIA:CD3G/CD3ZdimersIg heavy chain V-I region HG3 Ig kappa chain V-I region WEA Ig heavy chain V-III region JON Ig heavy chain V-III region WAS ABL1Ig kappa chain V-I region Kue Ig kappa chain V-III region IARC/BL41 Ig kappa chain V-III region NG9 Ig kappa chain V-III region CLL Ig kappa chain V-III region IARC/BL41 Ig lambda chain V-IV region MOL Ig kappa chain V-III region Ti Ig kappa chain V-III region IARC/BL41 IGLV3-22(1-?) Ig kappa chain V-I region DEE ADPCD3G Ig heavy chain V-III region CAM Ig lambda chain V-II region BUR Ig kappa chain V-I region BAN Ig kappa chain V-I region WEA Ig heavy chain V-III region BUT Ig lambda chain V-I region NEWM Ig lambda chain V-II region MGC IGLV7-43(1-?) Ig kappa chain V-II region RPMI 6410 Ig kappa chain V-III region HIC Ig kappa chain V-III region Ti IGLV3-25(1-?) Ig heavy chain V-I region ND IGLC6 IGLV1-44(1-?) Ig lambda chain V-I region NEWM Ig lambda chain V-II region NIG-58 Ig kappa chain V-III region Ti IGHG4 Ig kappa chain V-III region POM Ig lambda chain V-IV region MOL Ig kappa chain V-I region Lay Ig kappa chain V-I region WAT IGKC Ig heavy chain V-III region GA IGLV7-43(1-?) Ig heavy chain V-III region BUR Ig lambda chain V-V region DEL Ig heavy chain V-II region WAH Ig heavy chain V-III region BRO Ig kappa chain V region EV15 I(1,4,5)P3Ig heavy chain V-I region Mot Ig kappa chain V-IV region STH Motherfilament:branchingcomplex:daughterfilamentIGLV7-43(1-?) IP3 receptorhomotetramerIg lambda chain V-I region BL2 Ig kappa chain V-III region CLL Ig kappa chain V-I region Lay RAC1/CDC42:PAK dimerIGLC7 Ig kappa chain V-III region HAH ATPIg kappa chain V-II region Cum Ig heavy chain V-III region JON Ig kappa chain V-I region Ka Ig heavy chain V-I region HG3 Ig heavy chain V-III region NIE IGLV1-44(1-?) Ig heavy chain V-III region CAM Ig kappa chain V-I region WEA Ig kappa chain V-IV region Len Ig lambda chain V-I region NEW Ig kappa chain V-I region Scw Ig kappa chain V-I region CAR Ig kappa chain V-I region Roy IGLC1 Ig kappa chain V-III region WOL Ig kappa chain V-I region WAT IGLV7-46(1-?) IGKV1-5(23-?) CD3G IGLV3-16(1-?) Ig heavy chain V-II region NEWM Ig kappa chain V-I region WEA Ig heavy chain V-III region GA Ig heavy chain V-I region WOL Ig heavy chain V-I region HG3 Ig heavy chain V-III region BRO IGHG4 Ig kappa chain V-I region Mev CD3G Ig heavy chain V-III region TEI Ig lambda chain V-VI region EB4 IGLV3-22(1-?) Ig heavy chain V-II region WAH IGLC3 Ig kappa chain V-II region RPMI 6410 Ig kappa chain V-III region POM Ig kappa chain V-II region FR IGLV(23-?) Ig lambda chain V-II region MGC IGLV2-23(1-?) Ig lambda chain V-VI region AR Ig heavy chain V-II region MCE IGLV4-60(1-?) IGKV4-1(21-?) IGLV4-60(1-?) Ig lambda chain V-V region DEL IGKV4-1(21-?) IGLV4-3(1-?) Ig kappa chain V-I region Ka Ig heavy chain V-III region WEA Ig kappa chain V-III region WOL Ig lambda chain V-IV region MOL Ig kappa chain V-I region Bi IGLV2-11(1-?) Ig kappa chain V-I region Roy Ig heavy chain V-III region NIE IGLV4-69(1-?) Ig lambda chain V-I region VOR Ig heavy chain V-I region Mot Ig heavy chain V-III region POM Ig heavy chain V-III region BUR Ig heavy chain V-III region BUT Ig kappa chain V-III region VG Ig kappa chain V-I region Ka IGLV1-44(1-?) IgH heavy chain V-III region VH26 precursor Ig kappa chain V-III region SIE Ig kappa chain V-I region DEE VAV1 Ig lambda chain V-II region TOG Ig lambda chain V-II region BOH Ig lambda chain V-II region TRO Ig kappa chain V-III region VH Ig kappa chain V-I region Walker Ig kappa chain V-I region Lay Ig kappa chain V-IV region Len F-actinIg heavy chain V-II region OU Ig heavy chain V-III region KOL Ig kappa chain V-II region Cum IGLV11-55(1-?) IGLV7-46(1-?) Ig lambda chain V-I region VOR Ig heavy chain V-III region POM IgH heavy chain V-III region VH26 precursor Ig heavy chain V-III region TRO Ig kappa chain V-I region Kue Ig lambda chain V-II region NEI Ig heavy chain V-III region BUR IGHV(1-?) Ig kappa chain V-III region GOL Ig heavy chain V-II region COR Ig heavy chain V-I region Mot Ig lambda chain V-VI region WLT Ig lambda chain V-I region BL2 IGLV4-3(1-?) Ig lambda chain V-II region MGC IGLV2-11(1-?) Ig lambda chain V-I region MEM IGLV5-45(1-?) IGKVA18(21-?) ADPIg lambda chain V-III region SH Ig heavy chain V-II region WAH IGKV1-5(23-?) Ig heavy chain V-III region TIL Ig lambda chain V-II region WIN Ig lambda chain V-III region LOI Ig heavy chain V-II region ARH-77 Ig kappa chain V-II region FR IGKV1-5(23-?) Ig lambda chain V-VI region SUT CDC42:GTP:WASP/N-WASPIg lambda chain V-VI region AR Ig lambda chain V-VI region EB4 IGKV1-5(23-?) IGLV2-18(1-?) PhosphatidatephosphataseIg lambda chain V-IV region MOL IGLC2 Ig heavy chain V-III region WAS Ig kappa chain V-III region B6 Ig lambda chain V-I region NIG-64 Ig kappa chain V-I region Lay Ig heavy chain V-III region KOL Ig lambda chain V-I region EPS Ig heavy chain V-III region TRO p-6Y-CD247-1 Ig kappa chain V-I region HK101 IGHG2 RAC1/CDC42:p-S144,T423-PAKclusteredIgG-Ag:p-FCGRs:p-6Y-SYK:VAVIg kappa chain V-I region HK101 HSP90AA1,HSP90AB1Ig lambda chain V region 4A Ig lambda chain V-I region BL2 Ig heavy chain V-II region OU Ig kappa chain V region EV15 Ig kappa chain V-I region EU Ig lambda chain V-V region DEL Ig lambda chain V-IV region MOL IgH heavy chain V-III region VH26 precursor Ig lambda chain V-II region MGC IGLC3 Ig kappa chain V-I region Kue Ig kappa chain V-I region AU Ig kappa chain V-I region Walker Ig kappa chain V-I region Wes IGLV2-18(1-?) Ig heavy chain V-II region DAW Ig kappa chain V-I region EU Ig kappa chain V-III region CLL IGLV4-69(1-?) IGHG3 IGLC1 Motherfilament:ARP2/3:actin:GDPIg kappa chain V-III region VH Ig lambda chain V-VI region WLT Ig heavy chain V-III region TIL Ig heavy chain V-III region POM ATPIg heavy chain V-I region Mot IGLV3-22(1-?) IGLV5-37(1-?) Ig heavy chain V-II region ARH-77 Antigen Ig kappa chain V-III region B6 Ig lambda chain V-IV region X IGLV5-45(1-?) Ig kappa chain V-IV region STH Ig lambda chain V-I region VOR Ig kappa chain V-III region VH Ig lambda chain V-I region WAH Ig kappa chain V-IV region B17 Ig kappa chain V-I region Gal Ig lambda chain V-II region BO Ig heavy chain V-III region TIL Ig heavy chain V-I region ND Ig kappa chain V-I region WEA FCGR2A Ig kappa chain V-III region SIE Ig heavy chain V-III region GA Ig kappa chain V-I region WEA Ig kappa chain V-II region RPMI 6410 Ig lambda chain V-II region NEI Ig lambda chain V-I region HA IGLV1-44(1-?) Ig heavy chain V-III region BUR IGHG1 Ig lambda chain V-II region NIG-58 Ig kappa chain V-IV region JI Ig kappa chain V-III region IARC/BL41 Ig heavy chain V-III region TRO Ig lambda chain V-II region VIL Ig heavy chain V-III region DOB Ig lambda chain V-IV region Kern Ig kappa chain V-III region WOL Ig kappa chain V-II region TEW Ig heavy chain V-II region OU IgH heavy chain V-III region VH26 precursor Ig kappa chain V-I region Hau p-6Y-SYK VAV3 FCGR2AIg heavy chain V-III region GA Ig heavy chain V-III region TEI Ig lambda chain V-II region NIG-84 Ig lambda chain V-IV region MOL IGLV2-11(1-?) Ig kappa chain V-II region Cum Ig kappa chain V-II region RPMI 6410 Ig kappa chain V-II region MIL Ig lambda chain V-I region NEWM Ig lambda chain V-VI region NIG-48 Ig lambda chain V-I region MEM Ig heavy chain V-II region COR IGHG4 Ig lambda chain V-II region BOH Ig heavy chain V-III region HIL Ig kappa chain V-I region DEE Ig kappa chain V-I region WAT Ig heavy chain V-III region GA Ig kappa chain V-I region EU Ig heavy chain V-I region Mot Ig kappa chain V-I region Gal Ig lambda chain V-II region BUR Ig heavy chain V-II region DAW Ig kappa chain V-I region HK101 IGLV3-16(1-?) IGHG1 Ig kappa chain V-I region Kue Ig kappa chain V-I region Daudi Ig heavy chain V-III region WEA IGHG4 Ig kappa chain V-I region Hau Ig kappa chain V-II region Cum Ig lambda chain V-II region WIN IGLV(23-?) IGLV3-25(1-?) Ig heavy chain V-III region GAL Ig kappa chain V region EV15 p-Y160,Y171-CD3G IGLV2-18(1-?) Ig lambda chain V-IV region Hil IGKVA18(21-?) Ig lambda chain V-II region BO ATPIg heavy chain V-III region TEI Ig lambda chain V-VI region NIG-48 Ig lambda chain V-II region TRO Ig kappa chain V-I region HK101 IGLV4-60(1-?) IGHG2 p-6Y-SYK Ig kappa chain V-I region AG Ig kappa chain V-I region Mev Ig lambda chain V-II region BO IGLV(23-?) IGKV4-1(21-?) IGLV11-55(1-?) Ig kappa chain V-I region AG Ig heavy chain V-II region HE Ig heavy chain V-II region SESS IGHG1 Ig kappa chain V-I region Daudi Ig lambda chain V-IV region Kern CRKII:DOCK180:ELMOcomplex recruitedto phagocytic cupIg kappa chain V-I region AG IGLV3-27(1-?) Ig heavy chain V-III region BUR ATPIGHG2 IGLV3-25(1-?) IgG-Ag:FCGRIIIA:CD3G/CD3Z dimersIg kappa chain V-I region Ni Ig heavy chain V-II region NEWM Ig heavy chain V-III region TEI Ig lambda chain V-I region HA Ig heavy chain V-II region ARH-77 IGKVA18(21-?) Ig kappa chain V-II region GM607 Ig heavy chain V-II region MCE Ig heavy chain V-III region DOB IGLV7-46(1-?) IGHG2 Ig lambda chain V-VI region WLT IGHG2 IGLV3-25(1-?) Activated WAVE2 andWASP/N-WASP:ARP2/3complex:G-actinIGHG3 IGLV8-61(1-?) Ig kappa chain V-I region Kue Ig kappa chain V-IV region Len Activated WAVE2 andWASP/N-WASPIg kappa chain V-IV region JI Ig lambda chain V-II region NEI Ig kappa chain V-I region DEE Ig kappa chain V-I region Ni Ig heavy chain V-II region COR Ig lambda chain V-I region WAH Ig kappa chain V-III region SIE Ig lambda chain V-I region VOR Ig heavy chain V-III region CAM IGKC IGKV4-1(21-?) Ig lambda chain V-I region BL2 IGLC7 Ig lambda chain V-II region NEI Ig lambda chain V-IV region Hil Ig heavy chain V-I region ND Ig heavy chain V-III region BUR Ig kappa chain V-I region WEA Ig kappa chain V-IV region JI Ig heavy chain V-III region POM Ig lambda chain V-I region NIG-64 PiIg lambda chain V-IV region Hil Ig kappa chain V-II region RPMI 6410 IGHV(1-?) PI(4,5)P2IGLV2-33(1-?) Ig lambda chain V-I region NEWM Ig kappa chain V-I region HK101 Ig kappa chain V-III region HAH Ig heavy chain V-III region TRO Ig lambda chain V-II region NIG-84 IGLV3-22(1-?) WAVE RegulatoryComplexIGLC3 Ig heavy chain V-III region WAS IGKC Ig kappa chain V-I region Walker Ig lambda chain V-III region SH Ig kappa chain V-II region GM607 IGHV7-81(1-?) Ig lambda chain V-IV region Bau Ig lambda chain V-II region TOG Ig lambda chain V-II region WIN Ig heavy chain V-II region ARH-77 H2OIGLV5-45(1-?) Ig heavy chain V-II region HE IGLV1-44(1-?) Ig lambda chain V-I region EPS RAC1:GDPIGLV3-25(1-?) IGLV1-40(1-?) Ig lambda chain V region 4A Ig kappa chain V-I region Mev Ig lambda chain V-II region NIG-84 Ig kappa chain V-I region Mev p-6Y-CD247-1 Antigen Ig kappa chain V-II region MIL Ig lambda chain V-I region EPS Ig heavy chain V-III region WAS Ig kappa chain V-II region GM607 Ig kappa chain V-I region Mev Ig heavy chain V-II region COR Ig lambda chain V-IV region Bau Ig heavy chain V-II region COR Ig heavy chain V-III region GA Ig heavy chain V-III region GAL Ig kappa chain V-III region POM Ig kappa chain V-III region HIC IGLC6 Ig heavy chain V-I region WOL Ig kappa chain V-I region Hau Ig lambda chain V-VI region AR Ig kappa chain V-III region VH IGHV7-81(1-?) Ig heavy chain V-III region LAY Ig lambda chain V-I region HA IGLV3-12(1-?) Ig heavy chain V-III region TEI IGLV2-11(1-?) IGHG1 CD3G Ig lambda chain V-III region SH Ig lambda chain V-II region NIG-84 Ig heavy chain V-III region TRO Ig kappa chain V-III region GOL Ig lambda chain V-I region WAH Ig lambda chain V-II region BO IGLV1-44(1-?) IGLV11-55(1-?) Ig kappa chain V-I region Rei Ig heavy chain V-III region DOB Ig kappa chain V-I region Rei IGLV3-12(1-?) Ig kappa chain V-III region POM Ig heavy chain V-III region DOB Ig kappa chain V-IV region B17 Ig heavy chain V-III region POM Ig kappa chain V-I region Lay Ig heavy chain V-III region TIL H2OIGKVA18(21-?) Ig heavy chain V-III region BRO GTPIg lambda chain V-VI region EB4 IGKC Ig kappa chain V-III region VG IGLV2-33(1-?) Ig kappa chain V-I region Kue Ig kappa chain V-III region HIC Ig heavy chain V-III region GAL Ig kappa chain V-IV region STH Ig kappa chain V-I region HK101 Ig kappa chain V-I region Daudi p-Y288,Y304-FCGR2A Ig lambda chain V-I region MEM Ig heavy chain V-I region HG3 IGLV11-55(1-?) Ig heavy chain V-III region ZAP ITPR:I(1,4,5)P3tetramerIg lambda chain V region 4A Ig kappa chain V-III region IARC/BL41 Src-kinasesIg kappa chain V-III region WOL IGLV1-40(1-?) PiIGHG3 Ig heavy chain V-III region CAM Ig lambda chain V-III region LOI Ig kappa chain V-I region Rei Ig heavy chain V-III region LAY Ig kappa chain V-I region Wes p-6Y-CD247-1 IGLV5-45(1-?) Ig heavy chain V-III region NIE IGLV2-33(1-?) IGLV3-16(1-?) IGKVA18(21-?) Ig heavy chain V-I region SIE Ig heavy chain V-II region DAW Ig kappa chain V region EV15 Ig lambda chain V-IV region X Ig kappa chain V-III region POM Ig kappa chain V-I region Ka ATPIg kappa chain V-I region Walker Ig heavy chain V-III region KOL Ig kappa chain V-II region GM607 Ig lambda chain V-IV region X Ig heavy chain V-III region GAL Ig lambda chain V-I region NEW IGLV8-61(1-?) Ig kappa chain V-II region RPMI 6410 Ig kappa chain V-III region GOL IGLV4-3(1-?) Ig kappa chain V-III region CLL Ig heavy chain V-I region SIE Ig lambda chain V-VI region SUT Ig lambda chain V-VII region MOT IGLV10-54(1-?) IGHV(1-?) Ig lambda chain V-I region NEWM IGLC3 Ig kappa chain V-I region Roy p-6Y-CD247-1 Ig heavy chain V-III region NIE Ig heavy chain V-I region EU Ig lambda chain V-II region WIN IGLV5-37(1-?) IGLV2-11(1-?) Ig heavy chain V-III region GAL Ig lambda chain V-IV region Bau Ig kappa chain V-III region SIE Ig kappa chain V-III region GOL IGLC2 IGHG1 Ig heavy chain V-III region TUR IGLV5-37(1-?) Ig heavy chain V-III region NIE IGLV10-54(1-?) Ig kappa chain V-IV region JI Ig kappa chain V-II region GM607 IGLC3 Ig kappa chain V-I region Ni Ig lambda chain V-I region WAH Ig heavy chain V-III region GAL Ig kappa chain V-III region B6 IGHV(1-?) Ig heavy chain V-I region HG3 IGLC7 Ig kappa chain V-I region Lay Ig heavy chain V-II region MCE Ig lambda chain V-IV region Hil Ig lambda chain V-I region HA Ig lambda chain V-II region NIG-58 Ig heavy chain V-III region KOL Ig heavy chain V-II region OU IGLV2-18(1-?) Ig heavy chain V-III region GAL Ig lambda chain V-II region BO Ig lambda chain V-II region WIN Ig lambda chain V-VII region MOT IGLC3 Ig heavy chain V-II region COR Ig kappa chain V-I region Lay CD247-1 Ig kappa chain V-II region TEW FCGRIA:CD3GhomodimerIGLV7-46(1-?) IGLV3-27(1-?) Ig heavy chain V-III region TIL Ig kappa chain V-III region GOL Ig heavy chain V-III region JON FCGR1A Ig heavy chain V-I region EU Ig heavy chain V-III region NIE IGLV10-54(1-?) IGLC1 Motherfilament:branchingcomplexIg kappa chain V-I region AU IGLV3-22(1-?) Ig kappa chain V-I region Roy Ig lambda chain V-V region DEL Ig kappa chain V-I region AU Ig heavy chain V-III region HIL Ig lambda chain V-VII region MOT IGLC2 Ig kappa chain V-III region NG9 Ig heavy chain V-III region LAY Ig kappa chain V-I region OU Ig kappa chain V-I region Lay IGLV2-18(1-?) Ig kappa chain V-III region IARC/BL41 IGLV10-54(1-?) Ig heavy chain V-III region HIL Ig lambda chain V-II region MGC Ig heavy chain V-III region GAL Ig heavy chain V-III region HIL Ig heavy chain V-I region Mot Ig heavy chain V-III region TEI p-Y160,Y171-CD3G Ig lambda chain V-I region WAH IGLV10-54(1-?) IGLV3-27(1-?) Ig kappa chain V-III region CLL Ig lambda chain V-VI region EB4 Ig lambda chain V-II region NEI Ig kappa chain V-I region AG IGHV(1-?) IGLC6 Ig heavy chain V-I region SIE Ig heavy chain V-III region DOB Ig heavy chain V-II region ARH-77 Ig heavy chain V-III region TUR Ig heavy chain V-III region WEA Ig kappa chain V-I region AU IGLV3-25(1-?) IGLV3-25(1-?) FCGR1A IGLC6 Ig lambda chain V-IV region Kern Ig kappa chain V-I region CAR Ig heavy chain V-III region TUR Ig kappa chain V-I region Mev Ig kappa chain V-IV region Len Ig kappa chain V-II region Cum ATPIg heavy chain V-II region MCE IGKV4-1(21-?) Ig heavy chain V-III region BUR Ig lambda chain V-VII region MOT Ig heavy chain V-III region JON Ig heavy chain V-II region DAW Ig lambda chain V-VI region SUT IGLV2-33(1-?) Ig heavy chain V-II region SESS IGLC1 Ig lambda chain V region 4A Ig kappa chain V-III region HIC Ig lambda chain V-II region NIG-84 IGLV5-45(1-?) Ig lambda chain V-II region TOG IGLC3 Ig kappa chain V-III region HAH pCofilin: ActiveLIMK-1pLIMK dimer:HSP-90Ig lambda chain V-II region BOH Ig lambda chain V-IV region Hil Ig kappa chain V-II region GM607 Ig heavy chain V-III region WAS Ig kappa chain V-III region HAH Ig kappa chain V-III region SIE Ig lambda chain V-I region NIG-64 IGLV8-61(1-?) Ig kappa chain V-I region Roy Ig lambda chain V-II region BO IGLV11-55(1-?) Ig lambda chain V-II region VIL GDPIg heavy chain V-III region CAM p-Y173-VAV3 Ig kappa chain V-I region BAN Ig lambda chain V-II region NEI IGLV7-46(1-?) Ig kappa chain V-I region Gal Ig heavy chain V-II region NEWM Ig lambda chain V-I region VOR Ig heavy chain V-III region POM WIP family proteinsIg kappa chain V-III region B6 Ig kappa chain V-I region BAN IGLV4-69(1-?) Ig kappa chain V-I region Roy Antigen Ig heavy chain V-III region TEI Ig heavy chain V-II region COR Ig kappa chain V-II region TEW Ig heavy chain V-III region JON Ig kappa chain V-I region AU Ig kappa chain V-I region Lay clusteredIgG-Ag:p-FCGRs:p-6Y-SYK:PLCGIg lambda chain V-IV region Hil Ig heavy chain V-II region OU ADPIg kappa chain V-III region SIE Ig heavy chain V-II region OU Ig heavy chain V-II region ARH-77 IgH heavy chain V-III region VH26 precursor p-6Y-CD247-1 FCGR1A Ig lambda chain V-II region TRO FCGR1A Ig lambda chain V-IV region MOL IgH heavy chain V-III region VH26 precursor Ig heavy chain V-I region HG3 Ig heavy chain V-III region GA IGHG2 Ig heavy chain V-III region ZAP FCGR1A IGLV5-45(1-?) Ig lambda chain V-I region VOR IGLV5-37(1-?) Ig kappa chain V-III region Ti Ig kappa chain V-III region B6 Actin:ADPIg heavy chain V-III region DOB Ig kappa chain V-III region WOL Ig lambda chain V-VI region SUT Ig lambda chain V-I region NIG-64 Ig lambda chain V-II region NIG-84 Ig heavy chain V-I region Mot IGKC IGLV3-27(1-?) Ig lambda chain V-VII region MOT Ig lambda chain V-II region BUR IGLV3-16(1-?) Ig lambda chain V-I region MEM Ig kappa chain V-IV region Len ADPIg heavy chain V-III region TUR CDC42:GDPPKC-delta/epsilonIGLV4-69(1-?) PI(4,5)P2WASP/N-WASPAntigen IGLC6 Ig kappa chain V-I region Ni Ig kappa chain V-I region Scw Ig kappa chain V-I region Hau Ig heavy chain V-III region LAY Ig lambda chain V-II region VIL Ig heavy chain V-III region JON IGLV4-60(1-?) Ig lambda chain V-I region NEW Ig lambda chain V-I region BL2 FCGR1A Ig kappa chain V-IV region STH IGKVA18(21-?) IGLV10-54(1-?) PI3K:p-6Y-SYKIg kappa chain V-I region Daudi Ig kappa chain V-I region Hau H2OIGLV3-12(1-?) Ig heavy chain V-III region BUT Ig kappa chain V-III region CLL Ig kappa chain V-III region SIE clusteredIgG-Ag:FCGRsIg lambda chain V-IV region MOL Ig kappa chain V-IV region JI p-T,Y MAPK dimersIg kappa chain V-I region WAT Ig heavy chain V-III region BUR IGLV7-43(1-?) IGLV1-44(1-?) Ig kappa chain V-I region Wes Ig kappa chain V-I region DEE IGLC6 VAV1 IGHV(1-?) Ig kappa chain V-III region NG9 Ig lambda chain V-IV region X Ig heavy chain V-II region HE Ca2+IGLV1-40(1-?) IGLV11-55(1-?) Ig kappa chain V-I region EU Ig heavy chain V-III region BRO clusteredIgG-Ag:p-FCGRsIg lambda chain V-VI region NIG-48 IGLV1-36(1-?) IGLV1-40(1-?) IGLV11-55(1-?) Ig heavy chain V-III region LAY Ig lambda chain V-VI region EB4 Ig lambda chain V-II region NIG-84 Ig heavy chain V-III region TRO G-actinCFL1ATPIg heavy chain V-III region KOL Ig kappa chain V-I region Ka VAV1,2,3Ig kappa chain V-I region Bi IGLV4-3(1-?) Ig heavy chain V-II region NEWM Ig kappa chain V-I region EU IGKV4-1(21-?) Ig lambda chain V-I region HA Ig kappa chain V-III region VG IGLV4-3(1-?) IGKVA18(21-?) Ig heavy chain V-II region SESS Ig heavy chain V-III region TRO Ig heavy chain V-I region ND


Description

Phagocytosis is one of the important innate immune responses that function to eliminate invading infectious agents. Monocytes, macrophages, and neutrophils are the professional phagocytic cells. Phagocytosis is a complex process involving the recognition of invading foreign particles by specific types of phagocytic receptors and the subsequent internalization of the particles. Fc gamma receptors (FCGRs) are among the best studied phagocytic receptors that bind to Fc portion of immunoglobulin G (IgG). Through their antigen binding F(ab) end, antibodies bind to specific antigen while their constant (Fc) region binds to FCGRs on phagocytes. The clustering of FCGRs by IgG antibodies on the phagocyte initiates a variety of signals, which lead, through the reorganisation of actin cytoskeleton and membrane remodelling, to the formation of pseudopod and phagosome. Fc gamma receptors are classified into three classes: FCGRI, FCGRII and FCGRIII. Each class of these FCGRs consists of several individual isoforms. Among all these isoforms FCGRI, FCGRIIA and FCGRIIIA, are able to mediate phagocytosis (Joshi et al. 2006, Garcia Garcia & Rosales 2002, Nimmerjahn & Ravetch 2006). View original pathway at:Reactome.

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Bibliography

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  33. Van den Herik-Oudijk IE, Capel PJ, van der Bruggen T, Van de Winkel JG.; ''Identification of signaling motifs within human Fc gamma RIIa and Fc gamma RIIb isoforms.''; PubMed Europe PMC Scholia
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  35. Duchemin AM, Ernst LK, Anderson CL.; ''Clustering of the high affinity Fc receptor for immunoglobulin G (Fc gamma RI) results in phosphorylation of its associated gamma-chain.''; PubMed Europe PMC Scholia
  36. Lennartz MR, Lefkowith JB, Bromley FA, Brown EJ.; ''Immunoglobulin G-mediated phagocytosis activates a calcium-independent, phosphatidylethanolamine-specific phospholipase.''; PubMed Europe PMC Scholia
  37. Takenawa T, Miki H.; ''WASP and WAVE family proteins: key molecules for rapid rearrangement of cortical actin filaments and cell movement.''; PubMed Europe PMC Scholia
  38. Parrini MC, Lei M, Harrison SC, Mayer BJ.; ''Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1.''; PubMed Europe PMC Scholia
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  44. Aspenström P.; ''The WASP-binding protein WIRE has a role in the regulation of the actin filament system downstream of the platelet-derived growth factor receptor.''; PubMed Europe PMC Scholia
  45. Aizawa H, Wakatsuki S, Ishii A, Moriyama K, Sasaki Y, Ohashi K, Sekine-Aizawa Y, Sehara-Fujisawa A, Mizuno K, Goshima Y, Yahara I.; ''Phosphorylation of cofilin by LIM-kinase is necessary for semaphorin 3A-induced growth cone collapse.''; PubMed Europe PMC Scholia
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  47. Wu X, Suetsugu S, Cooper LA, Takenawa T, Guan JL.; ''Focal adhesion kinase regulation of N-WASP subcellular localization and function.''; PubMed Europe PMC Scholia
  48. Knaus UG, Wang Y, Reilly AM, Warnock D, Jackson JH.; ''Structural requirements for PAK activation by Rac GTPases.''; PubMed Europe PMC Scholia
  49. Bernard O.; ''Lim kinases, regulators of actin dynamics.''; PubMed Europe PMC Scholia
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  51. Indik ZK, Park JG, Hunter S, Schreiber AD.; ''The molecular dissection of Fc gamma receptor mediated phagocytosis.''; PubMed Europe PMC Scholia
  52. Huang MM, Indik Z, Brass LF, Hoxie JA, Schreiber AD, Brugge JS.; ''Activation of Fc gamma RII induces tyrosine phosphorylation of multiple proteins including Fc gamma RII.''; PubMed Europe PMC Scholia
  53. Rohatgi R, Ma L, Miki H, Lopez M, Kirchhausen T, Takenawa T, Kirschner MW.; ''The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly.''; PubMed Europe PMC Scholia
  54. Bompard G, Caron E.; ''Regulation of WASP/WAVE proteins: making a long story short.''; PubMed Europe PMC Scholia
  55. Iyer SS, Barton JA, Bourgoin S, Kusner DJ.; ''Phospholipases D1 and D2 coordinately regulate macrophage phagocytosis.''; PubMed Europe PMC Scholia
  56. Lee WL, Cosio G, Ireton K, Grinstein S.; ''Role of CrkII in Fcgamma receptor-mediated phagocytosis.''; PubMed Europe PMC Scholia
  57. Tay HK, Melendez AJ.; ''Fcgamma RI-triggered generation of arachidonic acid and eicosanoids requires iPLA2 but not cPLA2 in human monocytic cells.''; PubMed Europe PMC Scholia
  58. Rohatgi R, Nollau P, Ho HY, Kirschner MW, Mayer BJ.; ''Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway.''; PubMed Europe PMC Scholia
  59. Li R, Soosairajah J, Harari D, Citri A, Price J, Ng HL, Morton CJ, Parker MW, Yarden Y, Bernard O.; ''Hsp90 increases LIM kinase activity by promoting its homo-dimerization.''; PubMed Europe PMC Scholia
  60. Miki H, Suetsugu S, Takenawa T.; ''WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac.''; PubMed Europe PMC Scholia
  61. Chong C, Tan L, Lim L, Manser E.; ''The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity.''; PubMed Europe PMC Scholia
  62. Nakanishi O, Suetsugu S, Yamazaki D, Takenawa T.; ''Effect of WAVE2 phosphorylation on activation of the Arp2/3 complex.''; PubMed Europe PMC Scholia
  63. Corrotte M, Chasserot-Golaz S, Huang P, Du G, Ktistakis NT, Frohman MA, Vitale N, Bader MF, Grant NJ.; ''Dynamics and function of phospholipase D and phosphatidic acid during phagocytosis.''; PubMed Europe PMC Scholia
  64. Mitchell MA, Huang MM, Chien P, Indik ZK, Pan XQ, Schreiber AD.; ''Substitutions and deletions in the cytoplasmic domain of the phagocytic receptor Fc gamma RIIA: effect on receptor tyrosine phosphorylation and phagocytosis.''; PubMed Europe PMC Scholia
  65. Le Clainche C, Pantaloni D, Carlier MF.; ''ATP hydrolysis on actin-related protein 2/3 complex causes debranching of dendritic actin arrays.''; PubMed Europe PMC Scholia
  66. Deckert M, Tartare-Deckert S, Couture C, Mustelin T, Altman A.; ''Functional and physical interactions of Syk family kinases with the Vav proto-oncogene product.''; PubMed Europe PMC Scholia
  67. Massol P, Montcourrier P, Guillemot JC, Chavrier P.; ''Fc receptor-mediated phagocytosis requires CDC42 and Rac1.''; PubMed Europe PMC Scholia
  68. Xu X, Chong AS.; ''Vav in natural killer cells is tyrosine phosphorylated upon cross-linking of Fc gamma RIIIA and is constitutively associated with a serine/threonine kinase.''; PubMed Europe PMC Scholia
  69. Scott CC, Dobson W, Botelho RJ, Coady-Osberg N, Chavrier P, Knecht DA, Heath C, Stahl P, Grinstein S.; ''Phosphatidylinositol-4,5-bisphosphate hydrolysis directs actin remodeling during phagocytosis.''; PubMed Europe PMC Scholia
  70. Park H, Cox D.; ''Cdc42 regulates Fc gamma receptor-mediated phagocytosis through the activation and phosphorylation of Wiskott-Aldrich syndrome protein (WASP) and neural-WASP.''; PubMed Europe PMC Scholia
  71. Mullins RD, Heuser JA, Pollard TD.; ''The interaction of Arp2/3 complex with actin: nucleation, high affinity pointed end capping, and formation of branching networks of filaments.''; PubMed Europe PMC Scholia
  72. Kiener PA, Rankin BM, Burkhardt AL, Schieven GL, Gilliland LK, Rowley RB, Bolen JB, Ledbetter JA.; ''Cross-linking of Fc gamma receptor I (Fc gamma RI) and receptor II (Fc gamma RII) on monocytic cells activates a signal transduction pathway common to both Fc receptors that involves the stimulation of p72 Syk protein tyrosine kinase.''; PubMed Europe PMC Scholia
  73. Chavrier P.; ''May the force be with you: Myosin-X in phagocytosis.''; PubMed Europe PMC Scholia
  74. Hall AB, Gakidis MA, Glogauer M, Wilsbacher JL, Gao S, Swat W, Brugge JS.; ''Requirements for Vav guanine nucleotide exchange factors and Rho GTPases in FcgammaR- and complement-mediated phagocytosis.''; PubMed Europe PMC Scholia
  75. Moon KD, Post CB, Durden DL, Zhou Q, De P, Harrison ML, Geahlen RL.; ''Molecular basis for a direct interaction between the Syk protein-tyrosine kinase and phosphoinositide 3-kinase.''; PubMed Europe PMC Scholia
  76. Wang QJ.; ''PKD at the crossroads of DAG and PKC signaling.''; PubMed Europe PMC Scholia
  77. Amann KJ, Pollard TD.; ''The Arp2/3 complex nucleates actin filament branches from the sides of pre-existing filaments.''; PubMed Europe PMC Scholia
  78. Nimmerjahn F, Ravetch JV.; ''Fcgamma receptors: old friends and new family members.''; PubMed Europe PMC Scholia
  79. Agarwal A, Salem P, Robbins KC.; ''Involvement of p72syk, a protein-tyrosine kinase, in Fc gamma receptor signaling.''; PubMed Europe PMC Scholia
  80. Kim YJ, Sekiya F, Poulin B, Bae YS, Rhee SG.; ''Mechanism of B-cell receptor-induced phosphorylation and activation of phospholipase C-gamma2.''; PubMed Europe PMC Scholia
  81. Millard TH, Sharp SJ, Machesky LM.; ''Signalling to actin assembly via the WASP (Wiskott-Aldrich syndrome protein)-family proteins and the Arp2/3 complex.''; PubMed Europe PMC Scholia
  82. Le Clainche C, Carlier MF.; ''Regulation of actin assembly associated with protrusion and adhesion in cell migration.''; PubMed Europe PMC Scholia
  83. Ernst LK, Duchemin AM, Anderson CL.; ''Association of the high-affinity receptor for IgG (Fc gamma RI) with the gamma subunit of the IgE receptor.''; PubMed Europe PMC Scholia
  84. Tsang E, Giannetti AM, Shaw D, Dinh M, Tse JK, Gandhi S, Ho H, Wang S, Papp E, Bradshaw JM.; ''Molecular mechanism of the Syk activation switch.''; PubMed Europe PMC Scholia
  85. Swanson JA, Johnson MT, Beningo K, Post P, Mooseker M, Araki N.; ''A contractile activity that closes phagosomes in macrophages.''; PubMed Europe PMC Scholia
  86. Takeuchi M, Harigai M, Momohara S, Ball E, Abe J, Furuichi K, Kamatani N.; ''Cloning and characterization of DPPL1 and DPPL2, representatives of a novel type of mammalian phosphatidate phosphatase.''; PubMed Europe PMC Scholia
  87. Sekiya F, Poulin B, Kim YJ, Rhee SG.; ''Mechanism of tyrosine phosphorylation and activation of phospholipase C-gamma 1. Tyrosine 783 phosphorylation is not sufficient for lipase activation.''; PubMed Europe PMC Scholia
  88. Zalevsky J, Lempert L, Kranitz H, Mullins RD.; ''Different WASP family proteins stimulate different Arp2/3 complex-dependent actin-nucleating activities.''; PubMed Europe PMC Scholia
  89. Brooks DG, Qiu WQ, Luster AD, Ravetch JV.; ''Structure and expression of human IgG FcRII(CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes.''; PubMed Europe PMC Scholia
  90. Strzelecka A, Kwiatkowska K, Sobota A.; ''Tyrosine phosphorylation and Fcgamma receptor-mediated phagocytosis.''; PubMed Europe PMC Scholia
  91. Ghazizadeh S, Bolen JB, Fleit HB.; ''Tyrosine phosphorylation and association of Syk with Fc gamma RII in monocytic THP-1 cells.''; PubMed Europe PMC Scholia
  92. Cory GO, Garg R, Cramer R, Ridley AJ.; ''Phosphorylation of tyrosine 291 enhances the ability of WASp to stimulate actin polymerization and filopodium formation. Wiskott-Aldrich Syndrome protein.''; PubMed Europe PMC Scholia
  93. van Vugt MJ, Heijnen IA, Capel PJ, Park SY, Ra C, Saito T, Verbeek JS, van de Winkel JG.; ''FcR gamma-chain is essential for both surface expression and function of human Fc gamma RI (CD64) in vivo.''; PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
118475view20:32, 27 May 2021FinterlyRemoved incorrect and duplicated openControlledVocabulary PW:0000234
114947view16:47, 25 January 2021ReactomeTeamReactome version 75
113391view11:46, 2 November 2020ReactomeTeamReactome version 74
112853view13:31, 12 October 2020DeSlFixing ontology tag error
112849view13:02, 12 October 2020DeSlOntology Term : 'innate immune response pathway' added !
112596view15:57, 9 October 2020ReactomeTeamReactome version 73
101512view11:37, 1 November 2018ReactomeTeamreactome version 66
101048view21:19, 31 October 2018ReactomeTeamreactome version 65
100579view19:52, 31 October 2018ReactomeTeamreactome version 64
100128view16:38, 31 October 2018ReactomeTeamreactome version 63
99678view15:07, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99271view12:45, 31 October 2018ReactomeTeamreactome version 62
94053view13:54, 16 August 2017ReactomeTeamreactome version 61
93681view11:30, 9 August 2017ReactomeTeamreactome version 61
89466view13:21, 15 September 2016Mkutmonfix ontology tag annotation
87448view13:50, 22 July 2016MkutmonOntology Term : 'PW:0000234' added !
86805view09:26, 11 July 2016ReactomeTeamreactome version 56
83122view10:02, 18 November 2015ReactomeTeamVersion54
81461view12:59, 21 August 2015ReactomeTeamVersion53
76936view08:20, 17 July 2014ReactomeTeamFixed remaining interactions
76641view12:01, 16 July 2014ReactomeTeamFixed remaining interactions
75971view10:02, 11 June 2014ReactomeTeamRe-fixing comment source
75674view10:59, 10 June 2014ReactomeTeamReactome 48 Update
75029view13:54, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74673view08:44, 30 April 2014ReactomeTeamNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
2-LysophosphatidylcholineMetabolite428981 (Reactome)
ABL1Protein375987 (Reactome)
ADPMetaboliteCHEBI:16761 (ChEBI)
AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramerComplexR-HSA-5226920 (Reactome)
ARAMetabolite140356 (Reactome)
ARP2/3 complex (ATP bound)ComplexR-HSA-1861670 (Reactome)
ATPMetaboliteCHEBI:15422 (ChEBI)
Actin filament bound Myosin-XComplexR-HSA-1861625 (Reactome)
Actin:ADPComplexR-HSA-202994 (Reactome)
Activated WAVE2 and

WASP/N-WASP:ARP2/3

complex:G-actin		ComplexR-HSA-442565 (Reactome)
Activated WAVE2 and WASP/N-WASPComplexR-HSA-2197675 (Reactome)
Active LIMK1ComplexR-HSA-419630 (Reactome)
Antigen R-NUL-173548 (Reactome)
Antigen-antibody complexComplexR-HSA-173552 (Reactome)
BAIAP2Protein442574 (Reactome)
CD247-1 ProteinP20963-1 (Uniprot-TrEMBL)
CD3G ProteinP09693 (Uniprot-TrEMBL)
CDC42:GDPComplexR-HSA-418830 (Reactome)
CDC42:GTP, RAC1:GTPComplexR-HSA-389778 (Reactome)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteinsComplexR-HSA-2197683 (Reactome)
CDC42:GTP:WASP/N-WASPComplexR-HSA-442584 (Reactome)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteinsComplexR-HSA-2197680 (Reactome)
CDC42:GTPComplexR-HSA-182921 (Reactome)
CFL1Protein350751 (Reactome)
CRK:DOCK180:ELMO1,ELMO2ComplexR-HSA-2029141 (Reactome)
CRKII:DOCK180:ELMO

complex recruited

to phagocytic cup		ComplexR-HSA-2029130 (Reactome)
Ca2+Metabolite111875 (Reactome)
Ca2+Metabolite74016 (Reactome)
DAGsMetabolite112275 (Reactome)
F-actin201877 (Reactome)
FCGR1A ProteinP12314 (Uniprot-TrEMBL)
FCGR2A ProteinP12318 (Uniprot-TrEMBL)
FCGR2AProteinP12318 (Uniprot-TrEMBL)
FCGR3A ProteinP08637 (Uniprot-TrEMBL)
FCGRIA:CD3G homodimerComplexR-HSA-2029093 (Reactome)
FCGRIIIA:CD3G/CD3Z dimersComplexR-HSA-2029097 (Reactome)
G-actinComplexR-HSA-201857 (Reactome)
GDPMetabolite29420 (Reactome)
GTPMetabolite29438 (Reactome)
H2OMetabolite29356 (Reactome)
HSP90AA1,HSP90AB1ComplexR-HSA-419619 (Reactome)
I(1,4,5)P3Metabolite114520 (Reactome)
IGHG1 ProteinP01857 (Uniprot-TrEMBL)
IGHG2 ProteinP01859 (Uniprot-TrEMBL)
IGHG3 ProteinP01860 (Uniprot-TrEMBL)
IGHG4 ProteinP01861 (Uniprot-TrEMBL)
IGHV(1-?) ProteinA2KUC3 (Uniprot-TrEMBL)
IGHV7-81(1-?) ProteinQ6PIL0 (Uniprot-TrEMBL)
IGKC ProteinP01834 (Uniprot-TrEMBL)
IGKV1-5(23-?) ProteinP01602 (Uniprot-TrEMBL)
IGKV4-1(21-?) ProteinP06312 (Uniprot-TrEMBL)
IGKVA18(21-?) ProteinA2NJV5 (Uniprot-TrEMBL)
IGLC1 ProteinP0CG04 (Uniprot-TrEMBL)
IGLC2 ProteinP0CG05 (Uniprot-TrEMBL)
IGLC3 ProteinP0CG06 (Uniprot-TrEMBL)
IGLC6 ProteinP0CF74 (Uniprot-TrEMBL)
IGLC7 ProteinA0M8Q6 (Uniprot-TrEMBL)
IGLV(23-?) ProteinA2NXD2 (Uniprot-TrEMBL)
IGLV1-36(1-?) ProteinQ5NV67 (Uniprot-TrEMBL)
IGLV1-40(1-?) ProteinQ5NV69 (Uniprot-TrEMBL)
IGLV1-44(1-?) ProteinQ5NV81 (Uniprot-TrEMBL)
IGLV10-54(1-?) ProteinQ5NV86 (Uniprot-TrEMBL)
IGLV11-55(1-?) ProteinQ5NV87 (Uniprot-TrEMBL)
IGLV2-11(1-?) ProteinQ5NV84 (Uniprot-TrEMBL)
IGLV2-18(1-?) ProteinQ5NV65 (Uniprot-TrEMBL)
IGLV2-23(1-?) ProteinQ5NV89 (Uniprot-TrEMBL)
IGLV2-33(1-?) ProteinQ5NV66 (Uniprot-TrEMBL)
IGLV3-12(1-?) ProteinQ5NV85 (Uniprot-TrEMBL)
IGLV3-16(1-?) ProteinQ5NV64 (Uniprot-TrEMBL)
IGLV3-22(1-?) ProteinQ5NV75 (Uniprot-TrEMBL)
IGLV3-25(1-?) ProteinQ5NV90 (Uniprot-TrEMBL)
IGLV3-27(1-?) ProteinQ5NV91 (Uniprot-TrEMBL)
IGLV4-3(1-?) ProteinQ5NV61 (Uniprot-TrEMBL)
IGLV4-60(1-?) ProteinQ5NV79 (Uniprot-TrEMBL)
IGLV4-69(1-?) ProteinQ5NV92 (Uniprot-TrEMBL)
IGLV5-37(1-?) ProteinQ5NV68 (Uniprot-TrEMBL)
IGLV5-45(1-?) ProteinQ5NV82 (Uniprot-TrEMBL)
IGLV7-43(1-?) ProteinQ5NV80 (Uniprot-TrEMBL)
IGLV7-46(1-?) ProteinQ5NV83 (Uniprot-TrEMBL)
IGLV8-61(1-?) ProteinQ5NV62 (Uniprot-TrEMBL)
IP3 receptor homotetramerComplexR-HSA-169686 (Reactome)
ITPR:I(1,4,5)P3 tetramerComplexR-HSA-169696 (Reactome)
Ig heavy chain V-I region EU ProteinP01742 (Uniprot-TrEMBL)
Ig heavy chain V-I region HG3 ProteinP01743 (Uniprot-TrEMBL)
Ig heavy chain V-I region Mot ProteinP06326 (Uniprot-TrEMBL)
Ig heavy chain V-I region ND ProteinP01744 (Uniprot-TrEMBL)
Ig heavy chain V-I region SIE ProteinP01761 (Uniprot-TrEMBL)
Ig heavy chain V-I region WOL ProteinP01760 (Uniprot-TrEMBL)
Ig heavy chain V-II region ARH-77 ProteinP06331 (Uniprot-TrEMBL)
Ig heavy chain V-II region COR ProteinP01815 (Uniprot-TrEMBL)
Ig heavy chain V-II region DAW ProteinP01816 (Uniprot-TrEMBL)
Ig heavy chain V-II region HE ProteinP01818 (Uniprot-TrEMBL)
Ig heavy chain V-II region MCE ProteinP01817 (Uniprot-TrEMBL)
Ig heavy chain V-II region NEWM ProteinP01825 (Uniprot-TrEMBL)
Ig heavy chain V-II region OU ProteinP01814 (Uniprot-TrEMBL)
Ig heavy chain V-II region SESS ProteinP04438 (Uniprot-TrEMBL)
Ig heavy chain V-II region WAH ProteinP01824 (Uniprot-TrEMBL)
Ig heavy chain V-III region BRO ProteinP01766 (Uniprot-TrEMBL)
Ig heavy chain V-III region BUR ProteinP01773 (Uniprot-TrEMBL)
Ig heavy chain V-III region BUT ProteinP01767 (Uniprot-TrEMBL)
Ig heavy chain V-III region CAM ProteinP01768 (Uniprot-TrEMBL)
Ig heavy chain V-III region DOB ProteinP01782 (Uniprot-TrEMBL)
Ig heavy chain V-III region GA ProteinP01769 (Uniprot-TrEMBL)
Ig heavy chain V-III region GAL ProteinP01781 (Uniprot-TrEMBL)
Ig heavy chain V-III region HIL ProteinP01771 (Uniprot-TrEMBL)
Ig heavy chain V-III region JON ProteinP01780 (Uniprot-TrEMBL)
Ig heavy chain V-III region KOL ProteinP01772 (Uniprot-TrEMBL)
Ig heavy chain V-III region LAY ProteinP01775 (Uniprot-TrEMBL)
Ig heavy chain V-III region NIE ProteinP01770 (Uniprot-TrEMBL)
Ig heavy chain V-III region POM ProteinP01774 (Uniprot-TrEMBL)
Ig heavy chain V-III region TEI ProteinP01777 (Uniprot-TrEMBL)
Ig heavy chain V-III region TIL ProteinP01765 (Uniprot-TrEMBL)
Ig heavy chain V-III region TRO ProteinP01762 (Uniprot-TrEMBL)
Ig heavy chain V-III region TUR ProteinP01779 (Uniprot-TrEMBL)
Ig heavy chain V-III region WAS ProteinP01776 (Uniprot-TrEMBL)
Ig heavy chain V-III region WEA ProteinP01763 (Uniprot-TrEMBL)
Ig heavy chain V-III region ZAP ProteinP01778 (Uniprot-TrEMBL)
Ig kappa chain V region EV15 ProteinP06315 (Uniprot-TrEMBL)
Ig kappa chain V-I region AG ProteinP01593 (Uniprot-TrEMBL)
Ig kappa chain V-I region AU ProteinP01594 (Uniprot-TrEMBL)
Ig kappa chain V-I region BAN ProteinP04430 (Uniprot-TrEMBL)
Ig kappa chain V-I region Bi ProteinP01595 (Uniprot-TrEMBL)
Ig kappa chain V-I region CAR ProteinP01596 (Uniprot-TrEMBL)
Ig kappa chain V-I region DEE ProteinP01597 (Uniprot-TrEMBL)
Ig kappa chain V-I region Daudi ProteinP04432 (Uniprot-TrEMBL)
Ig kappa chain V-I region EU ProteinP01598 (Uniprot-TrEMBL)
Ig kappa chain V-I region Gal ProteinP01599 (Uniprot-TrEMBL)
Ig kappa chain V-I region HK101 ProteinP01601 (Uniprot-TrEMBL)
Ig kappa chain V-I region Hau ProteinP01600 (Uniprot-TrEMBL)
Ig kappa chain V-I region Ka ProteinP01603 (Uniprot-TrEMBL)
Ig kappa chain V-I region Kue ProteinP01604 (Uniprot-TrEMBL)
Ig kappa chain V-I region Lay ProteinP01605 (Uniprot-TrEMBL)
Ig kappa chain V-I region Mev ProteinP01612 (Uniprot-TrEMBL)
Ig kappa chain V-I region Ni ProteinP01613 (Uniprot-TrEMBL)
Ig kappa chain V-I region OU ProteinP01606 (Uniprot-TrEMBL)
Ig kappa chain V-I region Rei ProteinP01607 (Uniprot-TrEMBL)
Ig kappa chain V-I region Roy ProteinP01608 (Uniprot-TrEMBL)
Ig kappa chain V-I region Scw ProteinP01609 (Uniprot-TrEMBL)
Ig kappa chain V-I region WAT ProteinP80362 (Uniprot-TrEMBL)
Ig kappa chain V-I region WEA ProteinP01610 (Uniprot-TrEMBL)
Ig kappa chain V-I region Walker ProteinP04431 (Uniprot-TrEMBL)
Ig kappa chain V-I region Wes ProteinP01611 (Uniprot-TrEMBL)
Ig kappa chain V-II region Cum ProteinP01614 (Uniprot-TrEMBL)
Ig kappa chain V-II region FR ProteinP01615 (Uniprot-TrEMBL)
Ig kappa chain V-II region GM607 ProteinP06309 (Uniprot-TrEMBL)
Ig kappa chain V-II region MIL ProteinP01616 (Uniprot-TrEMBL)
Ig kappa chain V-II region RPMI 6410 ProteinP06310 (Uniprot-TrEMBL)
Ig kappa chain V-II region TEW ProteinP01617 (Uniprot-TrEMBL)
Ig kappa chain V-III region B6 ProteinP01619 (Uniprot-TrEMBL)
Ig kappa chain V-III region CLL ProteinP04207 (Uniprot-TrEMBL)
Ig kappa chain V-III region GOL ProteinP04206 (Uniprot-TrEMBL)
Ig kappa chain V-III region HAH ProteinP18135 (Uniprot-TrEMBL)
Ig kappa chain V-III region HIC ProteinP18136 (Uniprot-TrEMBL)
Ig kappa chain V-III region IARC/BL41 ProteinP06311 (Uniprot-TrEMBL)
Ig kappa chain V-III region NG9 ProteinP01621 (Uniprot-TrEMBL)
Ig kappa chain V-III region POM ProteinP01624 (Uniprot-TrEMBL)
Ig kappa chain V-III region SIE ProteinP01620 (Uniprot-TrEMBL)
Ig kappa chain V-III region Ti ProteinP01622 (Uniprot-TrEMBL)
Ig kappa chain V-III region VG ProteinP04433 (Uniprot-TrEMBL)
Ig kappa chain V-III region VH ProteinP04434 (Uniprot-TrEMBL)
Ig kappa chain V-III region WOL ProteinP01623 (Uniprot-TrEMBL)
Ig kappa chain V-IV region B17 ProteinP06314 (Uniprot-TrEMBL)
Ig kappa chain V-IV region JI ProteinP06313 (Uniprot-TrEMBL)
Ig kappa chain V-IV region Len ProteinP01625 (Uniprot-TrEMBL)
Ig kappa chain V-IV region STH ProteinP83593 (Uniprot-TrEMBL)
Ig lambda chain V region 4A ProteinP04211 (Uniprot-TrEMBL)
Ig lambda chain V-I region BL2 ProteinP06316 (Uniprot-TrEMBL)
Ig lambda chain V-I region EPS ProteinP06888 (Uniprot-TrEMBL)
Ig lambda chain V-I region HA ProteinP01700 (Uniprot-TrEMBL)
Ig lambda chain V-I region MEM ProteinP06887 (Uniprot-TrEMBL)
Ig lambda chain V-I region NEW ProteinP01701 (Uniprot-TrEMBL)
Ig lambda chain V-I region NEWM ProteinP01703 (Uniprot-TrEMBL)
Ig lambda chain V-I region NIG-64 ProteinP01702 (Uniprot-TrEMBL)
Ig lambda chain V-I region VOR ProteinP01699 (Uniprot-TrEMBL)
Ig lambda chain V-I region WAH ProteinP04208 (Uniprot-TrEMBL)
Ig lambda chain V-II region BO ProteinP01710 (Uniprot-TrEMBL)
Ig lambda chain V-II region BOH ProteinP01706 (Uniprot-TrEMBL)
Ig lambda chain V-II region BUR ProteinP01708 (Uniprot-TrEMBL)
Ig lambda chain V-II region MGC ProteinP01709 (Uniprot-TrEMBL)
Ig lambda chain V-II region NEI ProteinP01705 (Uniprot-TrEMBL)
Ig lambda chain V-II region NIG-58 ProteinP01713 (Uniprot-TrEMBL)
Ig lambda chain V-II region NIG-84 ProteinP04209 (Uniprot-TrEMBL)
Ig lambda chain V-II region TOG ProteinP01704 (Uniprot-TrEMBL)
Ig lambda chain V-II region TRO ProteinP01707 (Uniprot-TrEMBL)
Ig lambda chain V-II region VIL ProteinP01711 (Uniprot-TrEMBL)
Ig lambda chain V-II region WIN ProteinP01712 (Uniprot-TrEMBL)
Ig lambda chain V-III region LOI ProteinP80748 (Uniprot-TrEMBL)
Ig lambda chain V-III region SH ProteinP01714 (Uniprot-TrEMBL)
Ig lambda chain V-IV region Bau ProteinP01715 (Uniprot-TrEMBL)
Ig lambda chain V-IV region Hil ProteinP01717 (Uniprot-TrEMBL)
Ig lambda chain V-IV region Kern ProteinP01718 (Uniprot-TrEMBL)
Ig lambda chain V-IV region MOL ProteinP06889 (Uniprot-TrEMBL)
Ig lambda chain V-IV region X ProteinP01716 (Uniprot-TrEMBL)
Ig lambda chain V-V region DEL ProteinP01719 (Uniprot-TrEMBL)
Ig lambda chain V-VI region AR ProteinP01721 (Uniprot-TrEMBL)
Ig lambda chain V-VI region EB4 ProteinP06319 (Uniprot-TrEMBL)
Ig lambda chain V-VI region NIG-48 ProteinP01722 (Uniprot-TrEMBL)
Ig lambda chain V-VI region SUT ProteinP06317 (Uniprot-TrEMBL)
Ig lambda chain V-VI region WLT ProteinP06318 (Uniprot-TrEMBL)
Ig lambda chain V-VII region MOT ProteinP01720 (Uniprot-TrEMBL)
IgG-Ag:FCGRIA:CD3G homodimerComplexR-HSA-2029132 (Reactome)
IgG-Ag:FCGRIIAComplexR-HSA-1861689 (Reactome)
IgG-Ag:FCGRIIIA:CD3G/CD3Z dimersComplexR-HSA-2029163 (Reactome)
IgH heavy chain V-III region VH26 precursor ProteinP01764 (Uniprot-TrEMBL)
LIMK1Protein397785 (Reactome)
Mother filament:ARP2/3:actin:GDPComplexR-HSA-2197686 (Reactome)
Mother

filament:branching complex:daughter

filament		ComplexR-HSA-1861699 (Reactome)
Mother

filament:branching

complex		ComplexR-HSA-2029140 (Reactome)
Myosin-Actin filamentsComplexR-HSA-2029139 (Reactome)
Myosin-X dimerComplexR-HSA-1861665 (Reactome)
MyosinComplexR-HSA-2029109 (Reactome)
PAMetabolite1602448 (Reactome)
PAK1 dimerComplexR-HSA-445002 (Reactome)
PAK1Protein162629 (Reactome)
PCMetabolite429802 (Reactome)
PI(3,4)P2Metabolite202247 (Reactome)
PI(3,4,5)P3 MetaboliteCHEBI:16618 (ChEBI)
PI(3,4,5)P3MetaboliteCHEBI:16618 (ChEBI)
PI(4,5)P2Metabolite179856 (Reactome)
PI3K:p-6Y-SYKComplexR-HSA-2029149 (Reactome)
PI3KComplexR-HSA-74693 (Reactome)
PKC-delta/epsilonComplexR-HSA-198276 (Reactome)
PLA2G6Protein201596 (Reactome)
PLC gamma1,2ComplexR-HSA-1169089 (Reactome)
PLDComplexR-HSA-2029102 (Reactome)
Phosphatidate phosphataseComplexR-HSA-2029101 (Reactome)
PhosphatidylcholineMetabolite428980 (Reactome)
Phospho-PKC-delta/epsilonComplexR-HSA-198265 (Reactome)
PiMetabolite29372 (Reactome)
RAC1/CDC42:PAK dimerComplexR-HSA-2029159 (Reactome)
RAC1/CDC42:p-S144,T423-PAKComplexR-HSA-2029155 (Reactome)
RAC1:GDPComplexR-HSA-5674631 (Reactome)
RAC1:GTPComplexR-HSA-442641 (Reactome)
SH3 domain proteinsComplexR-HSA-2197679 (Reactome)
SYK ProteinP43405 (Uniprot-TrEMBL)
SYKProteinP43405 (Uniprot-TrEMBL)
Src family kinases (SFKs)ComplexR-HSA-1861597 (Reactome)
Src-kinasesComplexR-HSA-2197681 (Reactome)
VAV1 ProteinP15498 (Uniprot-TrEMBL)
VAV1,2,3ComplexR-HSA-430172 (Reactome)
VAV2 ProteinP52735 (Uniprot-TrEMBL)
VAV3 ProteinQ9UKW4 (Uniprot-TrEMBL)
WASP/N-WASPComplexR-HSA-201892 (Reactome)
WAVE Regulatory ComplexComplexR-HSA-2029154 (Reactome)
WIP family proteinsComplexR-HSA-2197678 (Reactome)
WRC:IRSp53/58:RAC1:GTP:PIP3ComplexR-HSA-2029147 (Reactome)
cholineMetabolite2263486 (Reactome)
clustered IgG-Ag:FCGRsComplexR-HSA-2029146 (Reactome)
clustered IgG-Ag:p-FCGRs:SYKComplexR-HSA-2029129 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCGComplexR-HSA-2029137 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAVComplexR-HSA-2029133 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCGComplexR-HSA-2029156 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-VAVComplexR-HSA-2029131 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYKComplexR-HSA-2029158 (Reactome)
clustered IgG-Ag:p-FCGRsComplexR-HSA-2029128 (Reactome)
clustered IgG-Ag:p-FCGRsComplexR-HSA-2029151 (Reactome)
p-4Y-PLCG1Protein167679 (Reactome)
p-6Y-CD247-1 ProteinP20963-1 (Uniprot-TrEMBL)
p-6Y-SYK ProteinP43405 (Uniprot-TrEMBL)
p-PLCGComplexR-HSA-2029095 (Reactome)
p-S144,T423-PAK1Protein399819 (Reactome)
p-T,Y MAPK dimersComplexR-HSA-1268261 (Reactome)
p-T508-LIMK1Protein399816 (Reactome)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3ComplexR-HSA-2029148 (Reactome)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3ComplexR-HSA-2130182 (Reactome)
p-Y160,Y171-CD3G ProteinP09693 (Uniprot-TrEMBL)
p-Y172-VAV2 ProteinP52735 (Uniprot-TrEMBL)
p-Y173-VAV3 ProteinQ9UKW4 (Uniprot-TrEMBL)
p-Y174-VAV1 ProteinP15498 (Uniprot-TrEMBL)
p-Y288,Y304-FCGR2A ProteinP12318 (Uniprot-TrEMBL)
pCofilin: Active LIMK-1ComplexR-HSA-399878 (Reactome)
pLIMK dimer:HSP-90ComplexR-HSA-419632 (Reactome)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
167686 (Reactome)
169680 (Reactome)
169683 (Reactome)
1861595 (Reactome)
1861621 (Reactome)
198314 (Reactome)
2-LysophosphatidylcholineArrow2029475 (Reactome)
2029268 (Reactome)
2029270 (Reactome)
2029271 (Reactome)
2029272 (Reactome)
2029273 (Reactome)
2029445 (Reactome)
2029449 (Reactome)
2029451 (Reactome)
2029452 (Reactome)
2029453 (Reactome)
2029454 (Reactome)
2029455 (Reactome)
2029456 (Reactome)
2029457 (Reactome)
2029458 (Reactome)
2029459 (Reactome)
2029460 (Reactome)
2029465 (Reactome)
2029466 (Reactome)
2029467 (Reactome)
2029468 (Reactome)
2029469 (Reactome)
2029471 (Reactome)
2029473 (Reactome)
2029475 (Reactome)
2029476 (Reactome)
2130194 (Reactome)
2197690 (Reactome)
2197691 (Reactome)
2197697 (Reactome)
2197698 (Reactome)
399950 (Reactome)
419644 (Reactome)
419645 (Reactome)
442586 (Reactome)
442592 (Reactome)
ABL1mim-catalysis2130194 (Reactome)
ADPArrow198314 (Reactome)
ADPArrow2029268 (Reactome)
ADPArrow2029271 (Reactome)
ADPArrow2029449 (Reactome)
ADPArrow2029453 (Reactome)
ADPArrow2029454 (Reactome)
ADPArrow2029459 (Reactome)
ADPArrow2029460 (Reactome)
ADPArrow2029469 (Reactome)
ADPArrow2130194 (Reactome)
ADPArrow2197698 (Reactome)
ADPArrow399950 (Reactome)
ADPArrow419644 (Reactome)
AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramerTBar169683 (Reactome)
ARAArrow2029475 (Reactome)
ARP2/3 complex (ATP bound)442592 (Reactome)
ATP1861595 (Reactome)
ATP198314 (Reactome)
ATP2029268 (Reactome)
ATP2029271 (Reactome)
ATP2029449 (Reactome)
ATP2029453 (Reactome)
ATP2029454 (Reactome)
ATP2029459 (Reactome)
ATP2029460 (Reactome)
ATP2029469 (Reactome)
ATP2029476 (Reactome)
ATP2130194 (Reactome)
ATP2197698 (Reactome)
ATP399950 (Reactome)
ATP419644 (Reactome)
Actin filament bound Myosin-XArrow1861595 (Reactome)
Actin:ADPArrow2029473 (Reactome)
Activated WAVE2 and WASP/N-WASP442592 (Reactome)
Activated WAVE2 and

WASP/N-WASP:ARP2/3

complex:G-actin		2029466 (Reactome)
Activated WAVE2 and

WASP/N-WASP:ARP2/3

complex:G-actin		Arrow442592 (Reactome)
Activated WAVE2 and WASP/N-WASPArrow2197690 (Reactome)
Active LIMK1399950 (Reactome)
Active LIMK1Arrow419644 (Reactome)
Active LIMK1mim-catalysis399950 (Reactome)
Antigen-antibody complex1861621 (Reactome)
Antigen-antibody complex2029455 (Reactome)
Antigen-antibody complex2029457 (Reactome)
BAIAP22029465 (Reactome)
CDC42:GDP2029445 (Reactome)
CDC42:GTP, RAC1:GTP2029456 (Reactome)
CDC42:GTP442586 (Reactome)
CDC42:GTP:WASP/N-WASP2197691 (Reactome)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins2197698 (Reactome)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteinsArrow2197691 (Reactome)
CDC42:GTP:WASP/N-WASPArrow442586 (Reactome)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteinsArrow2197698 (Reactome)
CDC42:GTPArrow2029445 (Reactome)
CFL1399950 (Reactome)
CRK:DOCK180:ELMO1,ELMO22197697 (Reactome)
CRKII:DOCK180:ELMO

complex recruited

to phagocytic cup		Arrow2197697 (Reactome)
CRKII:DOCK180:ELMO

complex recruited

to phagocytic cup		mim-catalysis2029467 (Reactome)
Ca2+169683 (Reactome)
Ca2+Arrow169683 (Reactome)
DAGsArrow167686 (Reactome)
DAGsArrow198314 (Reactome)
DAGsArrow2029468 (Reactome)
F-actin2029466 (Reactome)
FCGR2A1861621 (Reactome)
FCGRIA:CD3G homodimer2029455 (Reactome)
FCGRIIIA:CD3G/CD3Z dimers2029457 (Reactome)
G-actin2029473 (Reactome)
G-actin442592 (Reactome)
GDPArrow2029445 (Reactome)
GDPArrow2029451 (Reactome)
GDPArrow2029467 (Reactome)
GTP2029445 (Reactome)
GTP2029451 (Reactome)
GTP2029467 (Reactome)
H2O167686 (Reactome)
H2O2029468 (Reactome)
H2O2029471 (Reactome)
H2O2029475 (Reactome)
HSP90AA1,HSP90AB1419645 (Reactome)
HSP90AA1,HSP90AB1Arrow419644 (Reactome)
I(1,4,5)P3169680 (Reactome)
I(1,4,5)P3Arrow167686 (Reactome)
I(1,4,5)P3Arrow169683 (Reactome)
IP3 receptor homotetramer169680 (Reactome)
ITPR:I(1,4,5)P3 tetramerArrow169680 (Reactome)
ITPR:I(1,4,5)P3 tetramermim-catalysis169683 (Reactome)
IgG-Ag:FCGRIA:CD3G homodimerArrow2029455 (Reactome)
IgG-Ag:FCGRIIAArrow1861621 (Reactome)
IgG-Ag:FCGRIIIA:CD3G/CD3Z dimersArrow2029457 (Reactome)
LIMK12029460 (Reactome)
Mother filament:ARP2/3:actin:GDP2029473 (Reactome)
Mother filament:ARP2/3:actin:GDPArrow2197690 (Reactome)
Mother

filament:branching

complex		2197690 (Reactome)
Mother

filament:branching complex:daughter

filament		1861595 (Reactome)
Mother

filament:branching complex:daughter

filament		2029476 (Reactome)
Mother

filament:branching complex:daughter

filament		Arrow2029473 (Reactome)
Mother

filament:branching

complex		Arrow2029466 (Reactome)
Myosin-Actin filamentsArrow2029476 (Reactome)
Myosin-X dimer1861595 (Reactome)
Myosin-X dimermim-catalysis1861595 (Reactome)
Myosin2029476 (Reactome)
PA2029468 (Reactome)
PAArrow2029471 (Reactome)
PAK1 dimer2029456 (Reactome)
PAK1mim-catalysis2029454 (Reactome)
PC2029471 (Reactome)
PI(3,4)P21861595 (Reactome)
PI(3,4,5)P32029268 (Reactome)
PI(3,4,5)P32029458 (Reactome)
PI(3,4,5)P32029465 (Reactome)
PI(3,4,5)P3Arrow2029271 (Reactome)
PI(3,4,5)P3Arrow2029272 (Reactome)
PI(4,5)P2167686 (Reactome)
PI(4,5)P22029271 (Reactome)
PI(4,5)P2442586 (Reactome)
PI3K2029273 (Reactome)
PI3K:p-6Y-SYKArrow2029273 (Reactome)
PI3K:p-6Y-SYKmim-catalysis2029271 (Reactome)
PKC-delta/epsilon198314 (Reactome)
PKC-delta/epsilonmim-catalysis198314 (Reactome)
PLA2G6mim-catalysis2029475 (Reactome)
PLC gamma1,22029270 (Reactome)
PLDmim-catalysis2029471 (Reactome)
Phosphatidate phosphatasemim-catalysis2029468 (Reactome)
Phosphatidylcholine2029475 (Reactome)
Phospho-PKC-delta/epsilonArrow198314 (Reactome)
PiArrow1861595 (Reactome)
PiArrow2029468 (Reactome)
PiArrow2029473 (Reactome)
PiArrow2029476 (Reactome)
RAC1/CDC42:PAK dimer2029454 (Reactome)
RAC1/CDC42:PAK dimerArrow2029456 (Reactome)
RAC1/CDC42:p-S144,T423-PAKArrow2029454 (Reactome)
RAC1:GDP2029451 (Reactome)
RAC1:GDP2029467 (Reactome)
RAC1:GTP2029465 (Reactome)
RAC1:GTPArrow2029451 (Reactome)
RAC1:GTPArrow2029467 (Reactome)
SH3 domain proteins2197691 (Reactome)
SYK2029452 (Reactome)
Src family kinases (SFKs)mim-catalysis2029459 (Reactome)
Src-kinasesmim-catalysis2197698 (Reactome)
VAV1,2,32029458 (Reactome)
WASP/N-WASP442586 (Reactome)
WAVE Regulatory Complex2029465 (Reactome)
WIP family proteins2197691 (Reactome)
WRC:IRSp53/58:RAC1:GTP:PIP32130194 (Reactome)
WRC:IRSp53/58:RAC1:GTP:PIP3Arrow2029465 (Reactome)
cholineArrow2029471 (Reactome)
clustered IgG-Ag:FCGRs2029459 (Reactome)
clustered IgG-Ag:p-FCGRs2029452 (Reactome)
clustered IgG-Ag:p-FCGRs2029476 (Reactome)
clustered IgG-Ag:p-FCGRs:SYK2029449 (Reactome)
clustered IgG-Ag:p-FCGRs:SYKArrow2029452 (Reactome)
clustered IgG-Ag:p-FCGRs:SYKmim-catalysis2029449 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK2029270 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK2029273 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK2029458 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK2197697 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCG2029268 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCGArrow2029270 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCGmim-catalysis2029268 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV2029453 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAVArrow2029458 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG2029272 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCGArrow2029268 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-VAVArrow2029453 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-VAVmim-catalysis2029451 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYKArrow2029272 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYKArrow2029449 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYKmim-catalysis2029453 (Reactome)
clustered IgG-Ag:p-FCGRsArrow2029459 (Reactome)
clustered IgG-Ag:p-FCGRsArrow2029476 (Reactome)
p-4Y-PLCG1mim-catalysis167686 (Reactome)
p-PLCGArrow2029272 (Reactome)
p-S144,T423-PAK1Arrow2029454 (Reactome)
p-S144,T423-PAK1mim-catalysis2029460 (Reactome)
p-T,Y MAPK dimersmim-catalysis2029469 (Reactome)
p-T508-LIMK1419645 (Reactome)
p-T508-LIMK1Arrow2029460 (Reactome)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3Arrow2029469 (Reactome)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP32029469 (Reactome)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3Arrow2130194 (Reactome)
pCofilin: Active LIMK-1Arrow399950 (Reactome)
pLIMK dimer:HSP-90419644 (Reactome)
pLIMK dimer:HSP-90Arrow419645 (Reactome)
pLIMK dimer:HSP-90mim-catalysis419644 (Reactome)
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