Regulation of Wnt / B-catenin signaling by small molecule compounds (Homo sapiens)

From WikiPathways

Description

Quality Tags

Ontology Terms

Bibliography

1. White BD, Chien AJ, Dawson DW; ''Dysregulation of Wnt/β-catenin signaling in gastrointestinal cancers.''; Gastroenterology, 2012 PubMed Europe PMC Scholia

History

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Compare	Revision	Action	Time	User	Comment
	139127	view	03:21, 22 May 2025	Eweitz	Clear dimension cache
	139126	view	03:21, 22 May 2025	Eweitz	Economize layout
	139125	view	02:55, 22 May 2025	Eweitz	Use gene symbols
	139124	view	02:52, 22 May 2025	Eweitz	Fix PathVisio / Kaavio graphical discrepancy
	139123	view	02:52, 22 May 2025	Eweitz	Standardize case, refine cell layering
	139122	view	02:50, 22 May 2025	Eweitz	Fix truncated text by enlarging state
	139058	view	04:36, 17 May 2025	Khanspers	Increase font size, update layout
	137135	view	23:12, 27 February 2025	Khanspers	Modified description
	118061	view	10:37, 24 May 2021	Eweitz	Modified title
	111245	view	09:49, 27 July 2020	Melodyner	Ontology Term : 'growth factor signaling pathway' added !
	107145	view	14:23, 17 September 2019	MaintBot	ChEBI identifier normalization
	106496	view	21:44, 4 September 2019	Khanspers	Modified description
	105519	view	06:55, 8 August 2019	Khanspers	Modified description
	94746	view	15:14, 5 October 2017	Mkutmon	fix unconnected line
	93253	view	09:18, 9 August 2017	DeSl	Removed comment for node NC043
	93252	view	09:17, 9 August 2017	DeSl	Changed ID of NC043 from INCHI to CAS.
	93245	view	11:40, 8 August 2017	DeSl	Changed ID of 1a,25-(OH)2D3 to more stereospeific one; added 2 metabolite IDs which were previously not found.
	93087	view	13:32, 28 July 2017	DeSl	Chnaged all pubchem substance IDs to more stereospecified IDs
	90182	view	18:19, 21 October 2016	Khanspers	fixed unconnected
	90083	view	05:35, 13 October 2016	Khanspers	Modified title
	90082	view	05:34, 13 October 2016	Khanspers	cleanup
	88608	view	22:50, 11 August 2016	AAR&Co	Ontology Term : 'gastrointestinal carcinoma' added !
	88607	view	22:37, 11 August 2016	AAR&Co	Periodical save, work in progress
	88606	view	22:17, 11 August 2016	AAR&Co	Periodical save, work in progress
	87635	view	08:54, 25 July 2016	Lindarieswijk	Ontology Term : 'altered Wnt signaling pathway' added !
	85938	view	18:54, 21 June 2016	AAR&Co	Adjust Interactions
	85937	view	18:51, 21 June 2016	AAR&Co	Adjust Interactions to Wnt
	85935	view	18:35, 21 June 2016	AAR&Co	Fixed Unconnected Lines
	85934	view	18:32, 21 June 2016	AAR&Co	Modified description
	85873	view	15:14, 19 June 2016	AAR&Co	Modified description
	85872	view	15:05, 19 June 2016	AAR&Co	New pathway

External references

DataNodes

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Name	Type	Database reference	Comment
1a,25-(OH)2D3	Metabolite	13019066 (PubChem-compound)
APC	GeneProduct	ENSG00000134982 (Ensembl)
AXIN1	GeneProduct	ENSG00000103126 (Ensembl)
CGP049090	Metabolite		Identifier Not Found
CK1a	GeneProduct	1452 (NCBI Protein)
CK1e	GeneProduct	1454 (NCBI Protein)
Catenin beta-1	Protein	B4DGU4 (Uniprot-TrEMBL)
DKK3	GeneProduct	ENSG00000050165 (Ensembl)
DVL PDZ Domains	GeneProduct		General Term
DVL2	GeneProduct	ENSG00000004975 (Ensembl)
FZD Antibodies	GeneProduct		General Term
FZD7	GeneProduct	ENSG00000155760 (Ensembl)
FZD8	GeneProduct	ENSG00000177283 (Ensembl)
FZD	GeneProduct	FZD1 (HGNC)	FZD Not Specified
GSK3B	GeneProduct	ENSG00000082701 (Ensembl)
Glucocorticoids	Metabolite	53787563 (PubChem-substance)
IC261	Metabolite	53789627 (PubChem-substance)
ICG-001	Metabolite	136340203 (PubChem-substance)
IWP-2	Metabolite	2155128 (PubChem-compound)
LEF1	GeneProduct	ENSG00000138795 (Ensembl)
LRP	GeneProduct	ENSG00000123384 (Ensembl)	LRP Not Specified
MBOAT	GeneProduct	ENSG00000172197 (Ensembl)	MBOAT Family
NC043	Metabolite		Identifer Not Found
NSC668036	Metabolite	76620423 (PubChem-substance)
PRK115-584	Metabolite		Identifier Not Found
PRK118-310	Metabolite		Identifier Not Found
PRK118-744	Metabolite		Identifier Not Found
PRK222-815	Metabolite		Identifier Not Found
Pyrvinium	Metabolite	123097016 (PubChem-substance)
Retinoids	Metabolite	135307150 (PubChem-substance)
SFRP4	GeneProduct	ENSG00000106483 (Ensembl)
TCF4	GeneProduct	ENSG00000196628 (Ensembl)
TNKS	GeneProduct	ENSG00000173273 (Ensembl)
V3nter	GeneProduct		Identifier not found
WNT	GeneProduct	ENSG00000125084 (Ensembl)	Wnt Not Specified
Wnt Antibodies	GeneProduct		General Term
XAV939	Metabolite	254760594 (PubChem-substance)
iCRT14	Metabolite	162247440 (PubChem-substance)
iCRT3	Metabolite	275174963 (PubChem-substance)
iCRT5	Metabolite	164227414 (PubChem-substance)

Annotated Interactions

No annotated interactions