Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)

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27, 59, 74, 9113, 24, 36, 55, 72...10, 288, 4319, 34, 8440, 6716, 8923, 25, 59, 60, 8515, 42, 733, 30, 513861, 6319, 346, 14, 41, 46, 50...681, 10, 18, 28, 65...7920, 33, 47, 6917, 22, 32, 49, 56...18, 806858, 7138, 483535, 45, 625, 904, 3744, 57, 819, 2911, 2666, 7621, 54, 867712, 522, 643, 517, 53, 87cytosolendoplasmic reticulum lumenphagocytic cupIg lambda chain V-IV region Bau Ig lambda chain V-II region NIG-58 MYO5A PI(3,4,5)P3 Ig heavy chain V-II region DAW Ig kappa chain V-I region Wes Ig lambda chain V-II region BUR Ig lambda chain V-VI region WLT Ig lambda chain V-IV region X Ig kappa chain V-IV region Len Ig heavy chain V-III region KOL Ig kappa chain V-II region TEW Ig kappa chain V-II region MIL IGLC2 PLCG2 Ig lambda chain V region 4A Ig lambda chain V-III region LOI Ig heavy chain V-III region TUR p-Y256-WASL ACTG1 Ig kappa chain V-I region Daudi IGLV7-43(1-?) ADPIGLV3-12(1-?) Ig heavy chain V-II region SESS Ig lambda chain V-IV region Kern Ig kappa chain V-I region Ni Ig heavy chain V-II region COR Ig heavy chain V-III region LAY Ig heavy chain V-II region HE Ig kappa chain V-III region SIE Ig kappa chain V-III region GOL Ig heavy chain V-III region WEA Ig heavy chain V-III region JON IGKV1-5(23-?) Ig heavy chain V-III region LAY Ig lambda chain V-I region HA Ig lambda chain V-III region SH Ig heavy chain V-I region HG3 Ig lambda chain V-IV region X IGKV1-5(23-?) IGLV4-60(1-?) Ig kappa chain V-I region EU Ig heavy chain V-II region OU PI(3,4,5)P3 Ig lambda chain V-II region MGC p-Y150-WASF2 Ig kappa chain V-III region VG p-4S-ABI2 Ig kappa chain V-III region SIE Ig lambda chain V-I region NEW Ig kappa chain V-I region AU ITPR1 Ig heavy chain V-III region LAY Ig lambda chain V-VII region MOT Ig kappa chain V-IV region B17 Ig kappa chain V-III region GOL Ig lambda chain V region 4A Ig lambda chain V-IV region X PI(3,4,5)P3 Ig lambda chain V-I region NEW Ig heavy chain V-II region HE IGHV(1-?) Ig heavy chain V-III region NIE Ig lambda chain V-VI region EB4 Ig lambda chain V-I region HA Ig kappa chain V-I region BAN IGHG4 Ig heavy chain V-I region SIE IGLV3-12(1-?) IGKV1-5(23-?) Ig lambda chain V-II region TOG Ig kappa chain V-III region CLL Ig lambda chain V-II region TRO Ig kappa chain V-I region AU Ig heavy chain V-II region COR Ig kappa chain V-I region Gal FCGR2ANCKAP1L Activated WAVE2 andWASP/N-WASP:ARP2/3complex:G-actinIg lambda chain V-VI region WLT Ig heavy chain V-III region GA Ig heavy chain V-I region EU Ig lambda chain V-IV region Kern FCGR2A CD3G IGHG2 Ig kappa chain V-I region Gal IGLV2-23(1-?) Ig lambda chain V-I region BL2 Ig kappa chain V-II region MIL FCGR3A IGLV2-11(1-?) IGLV2-18(1-?) Ig kappa chain V-III region POM FAK1 IGLV7-46(1-?) Ig lambda chain V-I region NEWM IGLV4-69(1-?) Ig kappa chain V-III region VH Ig lambda chain V-VI region WLT ATP IGLV4-3(1-?) Ig lambda chain V-IV region Kern Ig kappa chain V-III region Ti F-actin ABI1 Ig lambda chain V-I region BL2 Ig kappa chain V-II region GM607 Ig kappa chain V-III region VG Ig lambda chain V-II region VIL IGLV3-22(1-?) IGLV7-46(1-?) ATPATP Ig kappa chain V-IV region B17 Ig kappa chain V-I region Ka p-Y288,Y304-FCGR2A IGLV3-25(1-?) ARPC5 Ig heavy chain V-III region NIE Ig kappa chain V-IV region B17 Ig lambda chain V-II region TRO WIPF2 Ig lambda chain V-IV region MOL Ig kappa chain V-II region TEW Ig kappa chain V-I region Hau Ig heavy chain V-III region JON Ig lambda chain V-VI region NIG-48 Ig lambda chain V-VI region AR Ig lambda chain V-VI region WLT Ig kappa chain V-II region MIL Ig heavy chain V-III region NIE IGLV7-43(1-?) Ig lambda chain V-VII region MOT Ig heavy chain V-I region Mot Ig kappa chain V-III region POM IGLC6 Ig heavy chain V-II region WAH Ig lambda chain V-VI region NIG-48 PI(3,4)P2 IGLV11-55(1-?) BAIAP2 Ig heavy chain V-I region SIE ATPIg heavy chain V-III region CAM IGKC Ig kappa chain V-IV region STH Ig lambda chain V-I region VOR Ig kappa chain V-I region Wes ARPC2 Ig lambda chain V-I region EPS p-Y288,Y304-FCGR2A Ig kappa chain V-IV region B17 Ig kappa chain V-I region WEA GDP IGLV2-33(1-?) IGHG4 Ig lambda chain V-I region MEM IGLC7 Ig kappa chain V-IV region B17 IGHG2 IGLV8-61(1-?) RAC1 Ig kappa chain V-I region DEE DAGsIg lambda chain V-I region HA Ig kappa chain V-I region EU FCGR1A ABI1 Ig heavy chain V-I region ND Ig heavy chain V-II region MCE p-4Y-PLCG1IGHG3 IGLC1 Ig lambda chain V-IV region X Ig heavy chain V-II region DAW IGLV1-40(1-?) Ig kappa chain V-I region Gal Ig kappa chain V-II region TEW IGLV1-44(1-?) Ig kappa chain V-III region HIC Ig heavy chain V-II region WAH Ig lambda chain V-I region HA Ig kappa chain V-I region Walker FGR Ig lambda chain V-IV region X Ig heavy chain V-III region ZAP Ig heavy chain V-II region WAH Ig heavy chain V-III region ZAP Ig kappa chain V-II region GM607 Motherfilament:ARP2/3:actin:GDPWAS Ig kappa chain V-I region Bi IGHG4 IGLV3-27(1-?) Ig lambda chain V-II region WIN Ig lambda chain V-VII region MOT IGLV5-37(1-?) ACTR3 IGHV7-81(1-?) IGLV7-46(1-?) Ig kappa chain V-I region CAR Ig kappa chain V-I region AG Ig lambda chain V-I region WAH Ig kappa chain V-I region Ka Ig lambda chain V-I region HA Ig kappa chain V-III region WOL Ig heavy chain V-III region GA Active LIMK1IGKVA18(21-?) Ig heavy chain V-II region NEWM Ig kappa chain V region EV15 Ig kappa chain V-I region Gal NCKAP1 Ig lambda chain V-I region EPS Ig heavy chain V-III region WAS Ig kappa chain V-I region EU Ig kappa chain V-II region TEW Ig lambda chain V-I region NIG-64 Ig kappa chain V-IV region Len Ig kappa chain V-III region CLL Ig kappa chain V-I region Rei Ig heavy chain V-III region TEI Ig heavy chain V-II region MCE IGLV3-27(1-?) BAIAP2 IGLC3 clusteredIgG-Ag:p-FCGRs:SYKIg kappa chain V-I region Wes Ig kappa chain V-IV region B17 Motherfilament:branchingcomplex:daughterfilamentIg kappa chain V-III region VG ARPC3 IGLV4-60(1-?) Ig heavy chain V-I region Mot IGLV3-12(1-?) Ig lambda chain V-IV region Kern Ig lambda chain V-VI region AR IGLV1-36(1-?) ARPC1B Ig heavy chain V-III region TUR p-Y288,Y304-FCGR2A Ig kappa chain V-II region RPMI 6410 Ig kappa chain V-I region Wes Ig kappa chain V-I region Wes Ig heavy chain V-III region ZAP Ig lambda chain V-V region DEL CDC42:GTP:WASP/N-WASPIg lambda chain V-II region NIG-58 Ig heavy chain V-I region SIE Ig lambda chain V-I region NIG-64 IgH heavy chain V-III region VH26 precursor IGLV3-25(1-?) Ig heavy chain V-I region ND IGHG4 PIK3R2 Ig lambda chain V-I region NEWM Ig kappa chain V-I region Wes Ig lambda chain V-II region BOH HSP90AB1 Ig kappa chain V-IV region JI GTP Ig kappa chain V-III region B6 pCofilin: ActiveLIMK-1ARPC3 Ig heavy chain V-III region BRO Ig lambda chain V-IV region Bau Ig kappa chain V-I region BAN p-Y151-WASF1 PCIg kappa chain V-I region HK101 WIPF2 Ig heavy chain V-III region ZAP Ig heavy chain V-II region DAW Ig heavy chain V-I region WOL Ig lambda chain V-II region NEI Ig heavy chain V-II region WAH Ig lambda chain V-II region VIL p-Y160,Y171-CD3G IGLV3-22(1-?) Ig lambda chain V-I region NEW p-Y288,Y304-FCGR2A p-Y151-WASF3 p-6Y-SYK Ig lambda chain V-II region NIG-58 ARPC4 IGLC3 IGKV1-5(23-?) WAS IGLV10-54(1-?) IGHV7-81(1-?) Ig heavy chain V-III region WEA NCK1 Ig kappa chain V-I region Rei Ig lambda chain V-II region TRO Ig heavy chain V-III region TEI Ig lambda chain V-I region MEM IGLV3-16(1-?) Ig lambda chain V-VI region WLT IGLV4-3(1-?) FCGR1A Ig heavy chain V-II region DAW Ig kappa chain V-III region VH PPAPDC1A ITPR3 IGLV3-16(1-?) p-4S-ABI2 IGLV8-61(1-?) Ig heavy chain V-III region ZAP Ig lambda chain V-II region WIN IGLV3-16(1-?) WIPF3 IGHV7-81(1-?) IGLV11-55(1-?) Ig kappa chain V-III region NG9 Ig kappa chain V-I region Roy Ig kappa chain V-I region HK101 IGLV1-36(1-?) p-T,Y MAPK dimersIg kappa chain V-III region Ti IGLV5-45(1-?) Ig kappa chain V-IV region JI ACTB(1-375) RAC1 Ig lambda chain V-I region NIG-64 PLC gamma1,2Ig lambda chain V-I region NIG-64 Ig kappa chain V-IV region JI FCGR1A p-4S-ABI2 Ig kappa chain V-I region EU NCK1 Ig kappa chain V-I region AU Ig heavy chain V-III region POM Ig kappa chain V-II region FR IGKC p-T566,T710,S729-PRKCE Ig lambda chain V-II region TOG Ig heavy chain V-III region LAY Ig heavy chain V-III region TUR p-Y150-WASF2 Ig kappa chain V-II region FR Ig kappa chain V-III region WOL Antigen IGLC3 Ig kappa chain V-I region WAT Ig kappa chain V-I region Walker p-6Y-CD247-1 Ig kappa chain V-III region NG9 Ig heavy chain V-I region ND WIPF2 IGLV3-12(1-?) Ig heavy chain V-I region SIE Ig lambda chain V-I region EPS Ig kappa chain V-III region IARC/BL41 Ig kappa chain V-I region Bi Ig kappa chain V-I region Walker Ig kappa chain V-I region Ka CRK Ig kappa chain V-IV region STH Ig kappa chain V-I region WEA p-Y291-WAS IGLV(23-?) Ig lambda chain V-I region EPS Ig lambda chain V-VII region MOT CYFIP2 Ig lambda chain V-I region EPS IGLV5-45(1-?) FCGR3A clusteredIgG-Ag:p-FCGRs:p-6Y-SYK:PLCGVAV3 Ig kappa chain V-II region Cum GTP IGLV3-22(1-?) IGLC3 Ig kappa chain V-III region IARC/BL41 Ig lambda chain V-I region MEM Ig lambda chain V-IV region X clusteredIgG-Ag:p-FCGRsIGLV1-40(1-?) PI(4,5)P2Ig heavy chain V-III region KOL FCGR3A Ig heavy chain V-I region EU PI(3,4,5)P3 Ig heavy chain V-II region SESS Ig lambda chain V-V region DEL IGLV7-46(1-?) Ig lambda chain V-VII region MOT p-Y172-VAV2 Ig kappa chain V-I region OU WIPF2 H2Op-4S-ABI2 Ig heavy chain V-III region BRO Ig heavy chain V-III region TIL Ig heavy chain V-III region BUT Ig heavy chain V-III region BUT Ig heavy chain V-III region CAM Ig heavy chain V-II region COR CDC42 Ig kappa chain V-I region Mev Ig kappa chain V-I region Walker VAV2 Ig lambda chain V-II region NIG-84 Ig kappa chain V-II region GM607 IGLV1-44(1-?) Ig kappa chain V-I region Kue GTP IGHG1 WIPF2 Ig kappa chain V-I region Ka IGLV2-18(1-?) Ig kappa chain V-I region WEA Ig heavy chain V-III region LAY Ig kappa chain V-II region TEW Ig kappa chain V-IV region B17 IGLV10-54(1-?) Ig kappa chain V-I region Mev Ig kappa chain V-I region Gal Ig heavy chain V-III region GAL Ig kappa chain V-I region DEE IGLC2 Ig lambda chain V-IV region MOL Ig heavy chain V-I region ND IGLV1-40(1-?) PRKCE IGLC7 Ig kappa chain V-III region WOL Ig kappa chain V-I region Roy Ig kappa chain V-I region AU Ig kappa chain V-I region Daudi Ig kappa chain V-I region WEA ABI2 Ig lambda chain V-I region WAH Ig kappa chain V-I region Kue IGKC Ig heavy chain V-II region COR Ig kappa chain V-I region Mev Ig kappa chain V-I region Scw PAK1 dimerFCGRIA:CD3GhomodimerIg heavy chain V-I region WOL Ig kappa chain V-II region MIL IGLC7 Ig lambda chain V-II region VIL Ig kappa chain V-II region RPMI 6410 Ig lambda chain V-I region NIG-64 Ig heavy chain V-II region ARH-77 Ig kappa chain V-III region CLL Ig heavy chain V-III region JON Ig lambda chain V-II region NEI Ig heavy chain V-I region HG3 IGLV7-46(1-?) Ig kappa chain V-I region Gal Ig heavy chain V-III region CAM NCKAP1 Ig heavy chain V-I region WOL WIP family proteinsIg heavy chain V-III region TEI Ig lambda chain V-II region NEI CYFIP2 Ig kappa chain V-I region Daudi Ig heavy chain V-I region SIE Ig kappa chain V-II region FR Ig heavy chain V-III region TIL Ig kappa chain V-II region MIL IGHG4 Ig lambda chain V-I region NEWM FCGR3A Ig heavy chain V-I region SIE Ig kappa chain V-II region Cum Ig heavy chain V-III region ZAP Ig lambda chain V-I region NEW Ig kappa chain V-III region POM NCKAP1 p-Y151-WASF1 Ig heavy chain V-II region WAH ITPR:I(1,4,5)P3tetramerIg kappa chain V-I region Ni Ig kappa chain V-II region GM607 IGHV(1-?) GRB2-1 PI(4,5)P2 Ig lambda chain V-VI region AR Ig lambda chain V-II region BO IGLV5-45(1-?) IGLV2-11(1-?) FCGR3A Ig heavy chain V-III region WEA Ig kappa chain V-I region AU Antigen IGHG4 Ig lambda chain V-IV region Hil Ig lambda chain V-II region NEI Ig kappa chain V-III region SIE ADPp-Y151-WASF3 IGLV7-46(1-?) Ig heavy chain V-III region TRO ARPC5 p-Y151-WASF1 PIK3R1 Ig heavy chain V-II region SESS Ig lambda chain V-I region EPS Ig lambda chain V-IV region MOL Ig heavy chain V-II region NEWM Ig kappa chain V-I region Rei IGLV11-55(1-?) Ig heavy chain V-I region Mot Ig kappa chain V-I region Ni Ig heavy chain V-II region OU CDC42 IgH heavy chain V-III region VH26 precursor Ig kappa chain V region EV15 p-Y160,Y171-CD3G IGLC6 IGHG4 Ig lambda chain V region 4A Ig lambda chain V-IV region X Ig kappa chain V-I region WAT Ig kappa chain V-I region HK101 IGLV1-36(1-?) Ig kappa chain V-I region Hau ADPIGHG4 Ig kappa chain V-II region MIL IGLV3-22(1-?) Ig kappa chain V-I region Kue Ig lambda chain V-II region BUR Ig lambda chain V-II region TOG Ig kappa chain V-I region Gal Ig lambda chain V-V region DEL ACTG1 p-Y151-WASF3 Ig kappa chain V-III region IARC/BL41 Ig heavy chain V-III region TRO ADP Ig kappa chain V-I region Lay Ig heavy chain V-I region WOL ARPC1A IGLV(23-?) IGLC7 Ig lambda chain V-II region TRO Ig lambda chain V-II region TRO IGLV11-55(1-?) IGHV(1-?) Ig kappa chain V region EV15 PAIg heavy chain V-I region EU IGLV2-18(1-?) Ig kappa chain V-I region OU Ig kappa chain V-I region CAR Ig kappa chain V-I region Mev Ig lambda chain V-VII region MOT Ig kappa chain V-I region Hau Ig lambda chain V-II region BO Ig heavy chain V-III region TUR p-Y151-WASF1 Ig lambda chain V-II region BUR Ig heavy chain V-III region WEA Ig kappa chain V-III region IARC/BL41 IGLV3-16(1-?) Ig lambda chain V-VI region AR PAK1 Ig heavy chain V-III region BUT Ig kappa chain V-I region Ni IGLC1 Ig heavy chain V-III region ZAP Ig kappa chain V-I region Wes ARPC3 Ig heavy chain V-III region TUR IGKV4-1(21-?) PLA2G6IGHG3 Ig heavy chain V-II region HE ABI1 RAC1:GDPIGLV4-60(1-?) Ig heavy chain V-III region TUR Ig lambda chain V-I region NEWM Ig lambda chain V-II region NIG-84 Ig kappa chain V-I region WAT IGHV(1-?) IGLV3-25(1-?) Ig heavy chain V-III region WEA ARPC1A Ig lambda chain V-VI region NIG-48 Ig kappa chain V-III region WOL NCK1 Ig heavy chain V-II region DAW IGLC7 ARPC5 Ig heavy chain V-III region LAY Ig kappa chain V-I region DEE Ig kappa chain V-IV region Len Ig lambda chain V-IV region Kern WIPF1 IGLV1-36(1-?) Ig lambda chain V-I region NEWM p-Y151-WASF3 Antigen GRB2-1 IgH heavy chain V-III region VH26 precursor Ig heavy chain V-I region Mot Ig kappa chain V-IV region JI Ig kappa chain V region EV15 IGLV2-18(1-?) Ig heavy chain V-I region HG3 CDC42:GDPIg lambda chain V-VI region EB4 Ig kappa chain V-I region Kue IGHG1 Ig heavy chain V-II region COR FCGR1A Ig kappa chain V-II region MIL VAV1,2,3Ig kappa chain V-I region Daudi Ig kappa chain V-III region IARC/BL41 IGLC6 Ig lambda chain V-II region NIG-84 IGLV(23-?) Ig heavy chain V-I region Mot CYFIP2 IGHG4 IGLV10-54(1-?) IgH heavy chain V-III region VH26 precursor IGLV3-22(1-?) IGLC3 IGLV1-44(1-?) ITPR3 FYN Ig kappa chain V-I region Walker FCGR1A Ig kappa chain V-I region Ni p-Y151,S,T-WASF3 Ig kappa chain V-III region VH Ig kappa chain V-I region Mev Ig lambda chain V region 4A Ig lambda chain V-I region MEM Ig heavy chain V-III region BUR Ig heavy chain V-III region LAY IGLV2-23(1-?) IGKVA18(21-?) Ig kappa chain V-I region BAN Ig heavy chain V-III region JON Ig kappa chain V-I region Rei Ig lambda chain V-II region WIN IGLV7-46(1-?) IGKVA18(21-?) Ig kappa chain V-III region POM Ig kappa chain V-III region SIE Ig kappa chain V region EV15 Ig lambda chain V-VI region EB4 Ig kappa chain V-III region POM Ig kappa chain V region EV15 Ig kappa chain V-I region WEA Ig kappa chain V-III region IARC/BL41 Ig heavy chain V-III region BUT Ig heavy chain V-I region EU Ig heavy chain V-III region TIL Ig heavy chain V-III region TRO p-PLCGIg kappa chain V-II region TEW IGLV1-40(1-?) Ig kappa chain V-I region Daudi Ig lambda chain V-I region WAH Ig lambda chain V-II region WIN Ig kappa chain V-I region CAR Ig lambda chain V-IV region Bau IGLV4-3(1-?) Ig heavy chain V-III region CAM Ig kappa chain V-III region POM Ig kappa chain V-II region Cum IGLV1-44(1-?) IGLC1 Ig kappa chain V-I region AU Ig heavy chain V-II region MCE Ig kappa chain V-II region MIL Ig heavy chain V-III region GAL IGHG1 Ig lambda chain V-III region SH ARPC1B IGLC2 IGLC6 Ig kappa chain V-III region CLL Ig heavy chain V-II region SESS Ig kappa chain V-III region Ti IGLC3 IGLV10-54(1-?) IGLV1-36(1-?) Antigen Ig heavy chain V-III region POM Ig kappa chain V-I region Bi IGKV1-5(23-?) Ig heavy chain V-I region SIE ABI2 Ig kappa chain V-I region HK101 IGLC2 Ig kappa chain V-I region Roy Ig lambda chain V-VI region AR IGLV8-61(1-?) IGLV10-54(1-?) Ig heavy chain V-III region NIE Ig kappa chain V region EV15 Ig kappa chain V-II region TEW Ig lambda chain V-VI region SUT Ig lambda chain V-VI region SUT IGLC7 p-5S-ABI1 IGLV5-37(1-?) Ig heavy chain V-II region MCE Ig lambda chain V-I region VOR IGLV5-45(1-?) Ig lambda chain V-VI region EB4 IGLV11-55(1-?) IGLV4-69(1-?) Ig lambda chain V-IV region MOL GTP ARPC5 Ig lambda chain V-II region VIL WIPF1 IGKVA18(21-?) p-4S-ABI2 IGLV10-54(1-?) Ig heavy chain V-III region TEI Ig kappa chain V-II region TEW FCGRIIIA:CD3G/CD3ZdimersIg heavy chain V-III region GA GTP Ig heavy chain V-I region WOL Ig kappa chain V-I region Bi Ig kappa chain V-I region Lay Ig kappa chain V-III region GOL Ig lambda chain V-IV region MOL Ig kappa chain V-I region Bi Ig kappa chain V-I region Mev Ig heavy chain V-II region HE Ig heavy chain V-II region DAW Ig kappa chain V-I region HK101 F-actin IGLV3-22(1-?) Ig heavy chain V-III region ZAP Ig lambda chain V-IV region Kern Ig kappa chain V-III region HIC Ig heavy chain V-II region OU ARPC5 IGLV8-61(1-?) p-Y150,S343,T346-WASF2 p-Y151,S,T-WASF1 Ig kappa chain V-I region WEA IGLV1-40(1-?) IGLV3-22(1-?) Ig heavy chain V-I region EU Ig kappa chain V-I region Hau Ig lambda chain V-III region LOI Ig kappa chain V-I region EU Ig kappa chain V-I region Walker Ig lambda chain V-II region WIN Ig heavy chain V-II region HE ATP Ig lambda chain V-I region HA Actin:ADPIg heavy chain V-III region HIL PI(3,4,5)P3 Ig lambda chain V-VI region SUT ACTR2 IGLV2-18(1-?) Ig heavy chain V-I region Mot Ig kappa chain V region EV15 Ig lambda chain V region 4A Ig lambda chain V-IV region X Ig heavy chain V-II region ARH-77 NCKAP1L Ig kappa chain V-II region RPMI 6410 ATPIGLV7-46(1-?) BAIAP2 Ig heavy chain V-III region HIL Ig heavy chain V-II region DAW Ig kappa chain V-III region VG Ig lambda chain V-VI region SUT Ig lambda chain V-II region BO Ig heavy chain V-III region WEA Ig kappa chain V-I region Scw Ig kappa chain V-I region HK101 GTPARP2/3 complex (ATPbound)Ig lambda chain V-I region EPS Ig kappa chain V-I region Roy p-Y256-WASL p-4Y-PLCG1 IGHG4 IGHG4 Ig kappa chain V-II region RPMI 6410 Ig kappa chain V-I region WEA Ig kappa chain V-I region DEE Ig kappa chain V-III region POM Ig kappa chain V-I region WEA Ig heavy chain V-II region SESS Ig lambda chain V-II region WIN Ig lambda chain V-II region TRO Ig lambda chain V-II region VIL Ig lambda chain V-III region SH NCKAP1L Ig kappa chain V-I region Rei Ig kappa chain V-I region OU Ig kappa chain V-III region B6 Ig heavy chain V-III region POM Ig lambda chain V-II region BO p-Y160,Y171-CD3G IGHV(1-?) PI(3,4,5)P3 Ig lambda chain V-I region NIG-64 clusteredIgG-Ag:p-FCGRs:p-6Y-SYKIg lambda chain V-IV region X Ig heavy chain V-II region SESS IGLV2-18(1-?) ACTR3 Ig heavy chain V-III region TRO IGLV4-69(1-?) Ig kappa chain V-I region Kue IGLV1-40(1-?) Ig heavy chain V-I region HG3 Ig heavy chain V-III region TEI Ig kappa chain V-II region RPMI 6410 IGHV7-81(1-?) MyosinATP ABI1 Ig heavy chain V-II region WAH Ig heavy chain V-II region SESS Ig lambda chain V-IV region Kern FCGR3A Ig kappa chain V-II region Cum p-6Y-SYK Ig lambda chain V-IV region Bau GTP Ig kappa chain V-I region WEA IGLV4-60(1-?) Ig heavy chain V-III region DOB IGLV3-16(1-?) Ig kappa chain V-I region Lay Ig heavy chain V-II region COR Ig lambda chain V-II region TRO IGLC6 ADPIGHG4 Ig kappa chain V-I region Bi Ig kappa chain V-I region Bi ARPC1B IGLV4-69(1-?) CDC42 Ig heavy chain V-II region COR IGLV4-60(1-?) Ig heavy chain V-III region WAS WIPF3 Ig kappa chain V-I region AG IGLV2-23(1-?) IGLV2-33(1-?) Ig heavy chain V-II region COR Ig kappa chain V-I region Scw Ig lambda chain V-II region WIN Ig kappa chain V-III region HIC PI(3,4,5)P3 ADPIg heavy chain V-III region WAS Ig lambda chain V-II region TOG NCKAP1 IGLV2-23(1-?) Ig lambda chain V-II region MGC Ig kappa chain V-III region SIE Ig heavy chain V-III region JON Ig heavy chain V-III region JON Ig lambda chain V-I region NEW IGHV7-81(1-?) ARPC1B IGHV7-81(1-?) Ig kappa chain V-III region POM Ig kappa chain V-I region AG FCGR3A IGLV4-69(1-?) Ig heavy chain V-III region TEI Ig kappa chain V-III region Ti p-Y288,Y304-FCGR2A F-actin Ig heavy chain V-I region EU IGKVA18(21-?) Ig kappa chain V-III region Ti Ig heavy chain V-III region GA RAC1 Ig lambda chain V-II region BOH Ig kappa chain V-III region NG9 CYFIP1 Ig heavy chain V-III region HIL Ig heavy chain V-III region JON IGLV3-27(1-?) CDC42 Ig heavy chain V-III region TUR Ig lambda chain V-VI region AR IGLV5-37(1-?) Ig kappa chain V-I region Roy Ig lambda chain V-I region HA Ig lambda chain V region 4A Ig kappa chain V-III region IARC/BL41 Ig kappa chain V-II region GM607 IGLV7-43(1-?) IGLV2-11(1-?) Ig kappa chain V-I region Daudi Phospho-PKC-delta/epsilonIg lambda chain V-V region DEL Ig kappa chain V-I region Walker Ig lambda chain V-VI region AR Ig kappa chain V-I region Mev Ig kappa chain V-III region POM Ig lambda chain V-II region TRO IGLV4-3(1-?) Ig heavy chain V-I region ND Ig heavy chain V-III region JON Ig kappa chain V-III region IARC/BL41 PPAPDC1B Ig heavy chain V-III region WAS IGLC6 Ig heavy chain V-III region HIL IGKV4-1(21-?) IGHG4 IGKV4-1(21-?) IGLC2 Ig lambda chain V-II region BO Ig lambda chain V-IV region MOL Ig kappa chain V-I region Scw p-T508-LIMK1 Ig lambda chain V-VI region NIG-48 Ig heavy chain V-I region WOL Ig kappa chain V-I region DEE Ig kappa chain V-I region OU Ig heavy chain V-III region TIL p-Y151-WASF1 NCKAP1 IGLV2-11(1-?) RAC1 IgH heavy chain V-III region VH26 precursor Ig kappa chain V-I region BAN ATPWAS Ig heavy chain V-III region NIE IGLC2 FCGR1A Ig kappa chain V-II region Cum Ig lambda chain V-I region MEM Ig kappa chain V-III region CLL BRK1 Ig lambda chain V-IV region Hil Ig lambda chain V-IV region X IgG-Ag:FCGRIIARAC1 IGLV3-22(1-?) Ig lambda chain V-I region WAH ABI2 Ig lambda chain V-I region NIG-64 Ig heavy chain V-III region DOB Ig heavy chain V-III region NIE IGLV8-61(1-?) IGHV7-81(1-?) Ig kappa chain V-I region Scw NCKAP1L Ig kappa chain V-III region B6 Ig kappa chain V-I region OU Ig lambda chain V-II region NIG-84 Ig kappa chain V-I region Roy ACTG1 Ig heavy chain V-III region HIL NCKAP1L Ig lambda chain V-I region HA Ig heavy chain V-II region ARH-77 p-Y160,Y171-CD3G p-5S-ABI1 IGLV3-22(1-?) PIK3CB Ig lambda chain V-VI region WLT Ig kappa chain V-I region Daudi IGLV3-27(1-?) Ig lambda chain V-III region SH IGLV(23-?) Ig kappa chain V-III region B6 Ig lambda chain V-II region MGC Ig kappa chain V-I region HK101 ARPC2 p-6Y-SYK PIK3CA Ig kappa chain V region EV15 Ig lambda chain V-VI region NIG-48 Ig heavy chain V-III region HIL IGLV7-46(1-?) IGLV(23-?) CD3G IGHG1 IGLV5-37(1-?) Ig kappa chain V-I region Kue IGLV1-36(1-?) GTPIGLV3-12(1-?) Ig kappa chain V-I region AG Ig lambda chain V-II region NEI IGHG3 Ig lambda chain V-I region EPS Ig kappa chain V region EV15 IGKC Ig kappa chain V-III region HIC Ig lambda chain V-II region BO Ig lambda chain V-I region NEWM Ig kappa chain V-I region Walker Ig lambda chain V-II region TOG Ig kappa chain V-I region AU Ig heavy chain V-II region COR p-Y151-WASF1 Ig kappa chain V-I region Scw ADPIg lambda chain V-I region WAH p-S,T508-LIMK1 Ig kappa chain V-I region OU Ig heavy chain V-III region KOL IGLV5-37(1-?) Ig heavy chain V-III region TRO IGLV3-16(1-?) Ig heavy chain V-II region NEWM Ig lambda chain V-II region VIL Ig kappa chain V-I region Daudi CDC42 WIPF1 Ig lambda chain V-II region BOH Ig lambda chain V region 4A Ig lambda chain V region 4A Ig heavy chain V-III region KOL Ig lambda chain V-VI region SUT Ig kappa chain V-I region DEE Ig kappa chain V-IV region Len Ig heavy chain V-III region LAY Ig heavy chain V-III region WAS IGLV2-33(1-?) IGHG3 Ig kappa chain V-II region Cum Ig kappa chain V-IV region Len Ig kappa chain V-I region EU ACTR2 IGLV4-60(1-?) CRKII:DOCK180:ELMOcomplex recruitedto phagocytic cupIg heavy chain V-III region BUR CDC42 Ig lambda chain V-II region BOH VAV3 Ig lambda chain V-II region NEI BAIAP2 Ig lambda chain V-IV region Bau Ig lambda chain V-I region NEWM Ig lambda chain V-II region TRO IgH heavy chain V-III region VH26 precursor Ig kappa chain V-I region WAT Ig kappa chain V-IV region Len Ig kappa chain V-I region Roy Ig heavy chain V-III region WEA IGLV11-55(1-?) GTP IGHG4 Ig heavy chain V-III region HIL Ig lambda chain V-II region WIN Ig heavy chain V-I region WOL IGLV5-45(1-?) Ig heavy chain V-II region HE Ig kappa chain V-I region AG p-Y151-WASF3 p-Y150-WASF2 p-Y151,S,T-WASF3 p-Y288,Y304-FCGR2A Ig lambda chain V-I region MEM IGLV7-43(1-?) GTP Ig lambda chain V-I region BL2 IgG-Ag:FCGRIA:CD3GhomodimerIGLV1-40(1-?) ACTR3 GTP Ig lambda chain V-IV region Hil Ig kappa chain V-I region Wes IGLV3-12(1-?) Ig kappa chain V-I region Hau IGLV3-12(1-?) p-6Y-SYK IGLV3-22(1-?) Ig heavy chain V-I region HG3 Ig heavy chain V-III region WAS Ig kappa chain V-III region POM Ig heavy chain V-III region WEA CYFIP1 Ig kappa chain V-I region WEA IGLC2 Ig heavy chain V-II region NEWM Ig heavy chain V-III region NIE Ig heavy chain V-II region MCE Ig lambda chain V-II region NIG-58 ABI2 IGHV(1-?) Ig lambda chain V-VI region AR Ig heavy chain V-III region BUT IGLV3-27(1-?) IGLC1 Ig lambda chain V-I region VOR Ig heavy chain V-III region TUR Ig heavy chain V-III region NIE Ig kappa chain V-I region WAT Ig kappa chain V-I region WEA p-Y151,S,T-WASF3 IGLV(23-?) IGHV(1-?) Ig kappa chain V-I region OU Ig kappa chain V-III region Ti IGLV1-44(1-?) Ig lambda chain V-II region MGC Ig heavy chain V-I region SIE Ig kappa chain V-III region CLL Ig kappa chain V-I region WEA Ig lambda chain V-I region VOR ADPIg lambda chain V-III region LOI Ig heavy chain V-II region SESS IGLV1-36(1-?) Ig kappa chain V-I region AG Ig lambda chain V-II region TOG ARPC3 SYK IGKC p-T185,Y187-MAPK1 IGKC Ig kappa chain V-I region EU IGHV7-81(1-?) ARPC2 Ig heavy chain V-I region SIE IGLV1-36(1-?) Ig kappa chain V-IV region B17 Ig heavy chain V-III region LAY p-Y150-WASF2 Ig heavy chain V-III region BUT PIK3R1 Ig kappa chain V-III region Ti IGLV2-18(1-?) Ig lambda chain V-II region NIG-58 Ig kappa chain V-IV region JI Ig heavy chain V-III region POM Ig lambda chain V-IV region Hil Ig lambda chain V-IV region Hil p-Y160,Y171-CD3G Ig lambda chain V-IV region MOL Ig lambda chain V-II region MGC Ig kappa chain V-IV region STH Ig lambda chain V-VI region AR ARAIg lambda chain V-V region DEL IGLV3-22(1-?) Ig lambda chain V-III region SH Ig heavy chain V-III region ZAP IGLV4-69(1-?) Ig heavy chain V-III region BUR Ig kappa chain V-I region AU Ig kappa chain V-II region FR Ig kappa chain V-III region GOL Ig lambda chain V-V region DEL CYFIP1 Ig heavy chain V-III region BUT Antigen IGLV8-61(1-?) Ig kappa chain V-I region Roy Ig heavy chain V-II region DAW ARPC2 CD3G p-5S-ABI1 Ig kappa chain V-I region WAT IGLC7 Ig lambda chain V-II region BOH Ig lambda chain V-II region BOH Ig lambda chain V-II region BO Ig lambda chain V-II region NEI Ig kappa chain V-I region WEA Ig heavy chain V-I region ND Ig lambda chain V-IV region Bau Ig lambda chain V-II region TOG Ig kappa chain V-I region HK101 Ig heavy chain V-III region HIL IGLV2-23(1-?) p-Y151,S,T-WASF1 Ig heavy chain V-III region TIL Ig kappa chain V-I region WEA Ig heavy chain V-II region MCE Ig heavy chain V-III region GA Ig kappa chain V-I region WAT Ig heavy chain V-I region HG3 WIPF3 Ig heavy chain V-III region TIL IGHV(1-?) FCGR1A Ig kappa chain V-II region Cum Ig lambda chain V-I region EPS Ig kappa chain V-III region VH Ig kappa chain V-III region HAH Ig lambda chain V-I region MEM Ig kappa chain V-I region EU Ig kappa chain V-III region HIC p-Y151,S,T-WASF1 Ig kappa chain V-III region NG9 GRB2-1 Ig lambda chain V-VI region EB4 Ig lambda chain V-II region NIG-58 IGLV5-45(1-?) Ig lambda chain V-II region WIN IGLV2-18(1-?) Ig kappa chain V-II region Cum Ig heavy chain V-III region BUR IGLV4-69(1-?) Ig heavy chain V-II region WAH ATPIg kappa chain V-III region NG9 p-6Y-CD247-1 NAD+ Ig kappa chain V-IV region B17 IGLC1 IGLV3-27(1-?) Ig kappa chain V-I region Daudi IGLV4-3(1-?) IGLV5-37(1-?) Ig heavy chain V-II region COR ABI2 Ig heavy chain V-III region WAS RAC1 GRB2-1 Ig kappa chain V-III region GOL IGHG3 Ig lambda chain V-III region LOI Ig kappa chain V-III region SIE ACTR3 Ig heavy chain V-II region WAH Ig kappa chain V-III region HIC IGLV10-54(1-?) Ig lambda chain V-V region DEL CYFIP2 2-LysophosphatidylcholineAHCYL1 p-Y150,S343,T346-WASF2 Ig kappa chain V-III region HAH Ig kappa chain V-I region CAR Ig kappa chain V-I region HK101 CYFIP2 Ig kappa chain V-III region HIC Ig lambda chain V-III region LOI IGKC IGLV7-43(1-?) IGLV1-44(1-?) RAC1 ACTB(1-375) Ig heavy chain V-III region GAL IGLC2 Ig lambda chain V-IV region MOL Ig kappa chain V-I region BAN ARPC1B WIPF2 MYO1C IGKV4-1(21-?) ATPCDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteinsIGLV5-37(1-?) IGKV1-5(23-?) IGLV3-22(1-?) Ig kappa chain V-I region EU Ig heavy chain V-III region TEI IGLV1-36(1-?) GTP Ig lambda chain V-II region NIG-58 Ig kappa chain V-I region OU Ig heavy chain V-II region OU Ig lambda chain V-I region EPS PI(3,4,5)P3Ig lambda chain V-I region VOR Ig kappa chain V-I region CAR IGLV7-43(1-?) Ig lambda chain V-II region TRO Ig kappa chain V-I region Ka Ig lambda chain V-I region NIG-64 IGLV3-25(1-?) Ig heavy chain V-I region EU Ig kappa chain V-III region CLL Ig heavy chain V-II region NEWM IGLV2-11(1-?) Ig heavy chain V-II region ARH-77 Ig kappa chain V-I region AG PI(3,4)P2Ig heavy chain V-I region HG3 Ig heavy chain V-III region HIL IGLV1-40(1-?) Ig lambda chain V-II region VIL Ig heavy chain V-III region TRO Ig lambda chain V-VI region NIG-48 Ig lambda chain V-IV region Hil p-Y150-WASF2 Ig lambda chain V-IV region MOL Ig lambda chain V-II region TRO Ig kappa chain V-III region HAH Ig heavy chain V-I region HG3 Ig lambda chain V-I region WAH Ig kappa chain V-II region GM607 FCGR1A Ig heavy chain V-III region BRO IGHV7-81(1-?) IGHG2 Ig lambda chain V-I region NEWM Ig heavy chain V-III region BUT Ig kappa chain V-I region Ka Ig kappa chain V-I region Ka NCKAP1L IGLC3 IGLC6 Ig kappa chain V-IV region STH Ig heavy chain V-III region DOB Ig kappa chain V-I region Mev Ig heavy chain V-III region TRO Ig kappa chain V-I region CAR Ig kappa chain V-III region POM Ig heavy chain V-I region EU RAC1 Ig lambda chain V-II region NIG-58 Ig kappa chain V-I region Gal Ig kappa chain V-III region B6 GTP Ig kappa chain V-III region HAH IGHG3 Ig lambda chain V-IV region Hil Ig kappa chain V-III region Ti Ig lambda chain V-I region WAH Ig kappa chain V-I region Bi H2OIg kappa chain V-III region HAH Ig kappa chain V-III region Ti Ig lambda chain V-I region MEM RAC1/CDC42:PAK dimerGTP Ig lambda chain V-VI region EB4 IGLV1-36(1-?) PLD1 Ig kappa chain V-II region FR ARPC1B Ig lambda chain V-IV region X G-actinIGLV4-69(1-?) Ig kappa chain V-I region WAT Ig heavy chain V-II region COR ATPIg kappa chain V-IV region JI F-actin Ig kappa chain V-II region RPMI 6410 Ig heavy chain V-III region TEI Ig heavy chain V-II region MCE Ig heavy chain V-I region HG3 IGLC2 RAC1 MYO9B Ig lambda chain V-VI region NIG-48 Ig kappa chain V-II region TEW PI(4,5)P2Ig lambda chain V-II region BO Ig heavy chain V-III region TIL IgH heavy chain V-III region VH26 precursor Ig heavy chain V-III region TIL Ig kappa chain V-I region Ka IGLV5-45(1-?) ACTB(1-375) Ig lambda chain V-II region VIL Ig kappa chain V-III region HIC IP3 receptorhomotetramerIg lambda chain V-VI region SUT Ig heavy chain V-III region TUR Ig heavy chain V-II region OU Ig heavy chain V-I region HG3 ADPIGLV7-43(1-?) NCKIPSD Ig lambda chain V-VI region AR ATPIg heavy chain V-III region TIL IGLC6 Ig lambda chain V-IV region X Ig kappa chain V-I region DEE ARPC4 Ig kappa chain V-I region OU IGLV8-61(1-?) Ig kappa chain V-III region VH Ig heavy chain V-II region NEWM ACTB(1-375) Ig kappa chain V-II region RPMI 6410 Ig heavy chain V-I region Mot Ig lambda chain V-II region TOG IGLV11-55(1-?) Ig lambda chain V-I region MEM Ig kappa chain V-I region BAN Ig kappa chain V-IV region B17 IGLV5-37(1-?) Ig kappa chain V-III region WOL IGLV1-44(1-?) Ig kappa chain V-II region FR Ig kappa chain V-I region Wes Ig kappa chain V-I region WAT FCGR1A Ig lambda chain V-II region NIG-84 Ig lambda chain V-II region NEI Ig kappa chain V-I region EU Ig lambda chain V-I region NEWM Ig lambda chain V-I region BL2 Ig kappa chain V-IV region B17 Ig heavy chain V-III region POM Ig heavy chain V-III region JON PI(4,5)P2 Ig kappa chain V-II region RPMI 6410 Ig kappa chain V-I region BAN IGLV5-37(1-?) p-Y291-WAS IGLC3 ARPC4 Ig heavy chain V-III region CAM p-6Y-CD247-1 IGLC6 Ig heavy chain V-III region BUT ADP Ig kappa chain V-III region Ti Ig lambda chain V-IV region Hil Ig lambda chain V-I region HA Ig heavy chain V-II region DAW Ig kappa chain V-I region Walker PiIg lambda chain V-II region TOG Ig lambda chain V-IV region Bau Ig heavy chain V-II region OU Ig lambda chain V-I region NIG-64 Ig lambda chain V-I region NEWM Ig heavy chain V-I region Mot Ig heavy chain V-III region ZAP Ig lambda chain V-IV region Bau ARPC2 Ig kappa chain V-IV region JI IGLV3-25(1-?) IGLV3-27(1-?) Ig lambda chain V-I region VOR Ig kappa chain V-I region AG Ig lambda chain V-II region BO Ig kappa chain V-I region WEA Ig lambda chain V-II region BOH Ig kappa chain V-I region Kue Activated WAVE2 andWASP/N-WASPIGLC2 Ig heavy chain V-III region ZAP IGLC2 Ig kappa chain V-III region GOL PI(3,4,5)P3Ig heavy chain V-I region SIE WASF2 CDC42:GTP:WASP/N-WASP:WIP:SH3 proteinsIg heavy chain V-III region TEI clusteredIgG-Ag:p-FCGRs:p-6Y-SYK:VAVIGKV4-1(21-?) HSP90AA1 Ig lambda chain V-II region WIN IgH heavy chain V-III region VH26 precursor IGLV4-3(1-?) Ig kappa chain V-I region Ni Ig heavy chain V-III region CAM Ig lambda chain V-II region MGC IGLV3-27(1-?) Ig lambda chain V-I region NIG-64 Ig heavy chain V-III region DOB IGLV2-33(1-?) Ig kappa chain V-II region RPMI 6410 Ig kappa chain V-I region HK101 IGLV2-11(1-?) p-Y150,S343,T346-WASF2 ADPIg lambda chain V-II region TOG Ig kappa chain V-III region GOL PLCG1 IGKV1-5(23-?) Ig heavy chain V-III region KOL IGLV1-44(1-?) Ig lambda chain V-I region VOR Ig heavy chain V-III region BRO Ig kappa chain V-III region CLL Ig lambda chain V-II region VIL ATPIg heavy chain V-III region TEI Ig lambda chain V-V region DEL NCK1 Ig kappa chain V-IV region JI IGKVA18(21-?) Ig kappa chain V-I region DEE IGLV11-55(1-?) IGLV11-55(1-?) Ig heavy chain V-III region GAL Ig lambda chain V region 4A IGLV3-27(1-?) Ig kappa chain V-I region Walker WAVE RegulatoryComplexIGLV1-40(1-?) Ig kappa chain V-I region Wes p-5S-ABI1 RAC1/CDC42:p-S144,T423-PAKIg heavy chain V-II region HE IGKC Ig kappa chain V-III region SIE Ig heavy chain V-III region TUR Ig kappa chain V-I region Kue Ig kappa chain V-III region HAH Ig heavy chain V-III region CAM ARPC4 IGLV2-33(1-?) Ig lambda chain V-II region NIG-84 Ig lambda chain V-II region MGC WASF1 p-6Y-SYK Ig kappa chain V-I region Mev NCKAP1L Ig kappa chain V-I region Gal IGLV3-22(1-?) Ig kappa chain V-II region GM607 FCGR1A Ig kappa chain V-I region Daudi ADPIGKV1-5(23-?) Ig kappa chain V-I region Wes Ig heavy chain V-III region BUT ACTB(1-375) IGLV10-54(1-?) IGLV5-45(1-?) Ig heavy chain V-I region WOL IGLV8-61(1-?) IGLV5-37(1-?) Ig heavy chain V-II region SESS IGLV11-55(1-?) Ig heavy chain V-I region ND ACTG1 CYFIP2 Ig heavy chain V-I region SIE Ig heavy chain V-II region ARH-77 NCKIPSD Ig kappa chain V-III region CLL Ig heavy chain V-II region MCE Ig heavy chain V-III region HIL IGKC Ig lambda chain V-II region BUR Ig lambda chain V-III region LOI IGLV4-60(1-?) Ig heavy chain V-III region HIL ADPIGLV10-54(1-?) IGLV4-3(1-?) IGLV10-54(1-?) Ig heavy chain V-III region GAL Ig kappa chain V-I region WAT Ig lambda chain V-I region WAH Ig heavy chain V-III region LAY Ig kappa chain V-II region GM607 IGLC6 Ig kappa chain V-IV region B17 Ig kappa chain V-I region Roy Ig kappa chain V-I region AG Ig kappa chain V-III region NG9 ABI2 Ig lambda chain V-IV region Kern CDC42 Ig kappa chain V-III region VG Ig lambda chain V-IV region Bau Ig lambda chain V-VI region SUT Ig heavy chain V-I region ND Ig kappa chain V-I region Scw IGLV2-23(1-?) ChoIg kappa chain V-I region Lay Ig kappa chain V-III region HAH FCGR1A Ig lambda chain V-I region HA Ig heavy chain V-III region KOL IGLV7-46(1-?) IGLC2 Ig lambda chain V-II region MGC Ig lambda chain V-I region MEM ACTB(1-375) RAC1 IGLV2-11(1-?) Ig kappa chain V-II region Cum p-6Y-CD247-1 IGLV2-33(1-?) Ig kappa chain V-III region NG9 Ig lambda chain V-I region BL2 IGLV2-18(1-?) Ca2+Ig lambda chain V-II region BO Ig lambda chain V-VI region SUT Ig heavy chain V-II region NEWM BRK1 IGLV2-33(1-?) Ig heavy chain V-II region HE Ig lambda chain V-IV region X Ig lambda chain V-I region NEW Ig heavy chain V-III region DOB IGLV2-11(1-?) Ig lambda chain V-VI region AR Ig lambda chain V-VI region EB4 Ig heavy chain V-III region HIL Ig lambda chain V-II region WIN Ig kappa chain V-I region Daudi Ig kappa chain V-I region DEE FCGR1A p-6Y-SYK Ig heavy chain V-II region MCE Ig heavy chain V-I region EU Ig heavy chain V-III region GAL ELMO2 WIPF3 Ig heavy chain V-III region DOB IGLV5-37(1-?) PI(3,4,5)P3 Ig lambda chain V-II region BOH PI(4,5)P2 p-6Y-CD247-1 Ig kappa chain V-I region Daudi Ig kappa chain V-IV region STH IGLV1-44(1-?) WIPF2 Ig kappa chain V-IV region B17 Ig kappa chain V-I region Hau p-4S-ABI2 p-Y291-WAS PLD2 IGLV3-16(1-?) IGLC7 Ig heavy chain V-II region COR Ig kappa chain V-III region CLL IGHV7-81(1-?) Ig lambda chain V region 4A Ig kappa chain V-I region Wes ARPC5 Ig lambda chain V-II region NIG-84 Ig lambda chain V-IV region Kern MYO9B IGKV1-5(23-?) Ig kappa chain V-I region DEE Ig heavy chain V-III region GA IGLV2-11(1-?) WIPF3 Ig heavy chain V-III region GA IGLV3-16(1-?) Ig kappa chain V-I region AG GDPIg kappa chain V-I region DEE IGLV7-43(1-?) Ig kappa chain V-I region Ka Ig lambda chain V-IV region Bau HSP90AB1 IGLV3-16(1-?) Ig lambda chain V-II region TOG Ig kappa chain V-I region WAT IGLV2-33(1-?) Ig heavy chain V-II region OU NCKIPSD p-Y160,Y171-CD3G ABI2 Ig heavy chain V-III region HIL CDC42 CDC42 Ig heavy chain V-III region BUR IGHG2 Ig heavy chain V-I region WOL Ig heavy chain V-III region GAL Ig lambda chain V-I region BL2 Ig heavy chain V-II region ARH-77 Ig heavy chain V-II region WAH IGLV1-36(1-?) Ig heavy chain V-III region GA Ig heavy chain V-II region OU Ig kappa chain V-I region AU IGLV8-61(1-?) Myosin-ActinfilamentsIGLV5-37(1-?) Ig kappa chain V-I region CAR Ig kappa chain V-I region HK101 IGLV3-16(1-?) Ig lambda chain V-I region WAH GTP p-Y151,S,T-WASF1 PI(3,4,5)P3 Ig lambda chain V-V region DEL Ig heavy chain V-III region GA IGLV3-12(1-?) Ig heavy chain V-III region BRO IGLV8-61(1-?) p-Y173-VAV3 CYFIP1 Ig lambda chain V-II region BUR Ig heavy chain V-II region MCE IGLV3-22(1-?) Ig kappa chain V-III region GOL Ig kappa chain V-II region GM607 Ig kappa chain V-III region HIC Ig kappa chain V-I region Daudi Ig kappa chain V-III region Ti Ig heavy chain V-I region WOL Ig lambda chain V-I region HA Ig heavy chain V-II region SESS Ig heavy chain V-III region CAM Ig lambda chain V-I region BL2 Ig lambda chain V-II region TRO pLIMK dimer:HSP-90Ig lambda chain V-I region WAH Ig heavy chain V-III region TUR Ig lambda chain V-IV region Kern Ig kappa chain V-III region Ti BRK1 Ig heavy chain V-I region EU IGLV2-33(1-?) IGLV2-11(1-?) Ig heavy chain V-III region TIL Ig heavy chain V-III region GAL Ig kappa chain V-II region MIL IGLV7-43(1-?) Ig kappa chain V-I region Scw MYH9 IGLV2-18(1-?) Ig kappa chain V-III region VG Ig lambda chain V-I region EPS Ig lambda chain V-II region NIG-84 Ig heavy chain V-II region SESS Ig kappa chain V-IV region JI Ig kappa chain V-I region Gal Ig heavy chain V-III region BRO Ig kappa chain V-II region TEW Ig lambda chain V-IV region Kern Ig kappa chain V-I region Walker Ig kappa chain V-I region Mev Ig kappa chain V-III region B6 Ig heavy chain V-I region ND IGLV2-33(1-?) Ig kappa chain V-I region Kue Ig heavy chain V-III region ZAP N-WASP Ig lambda chain V-II region BOH Ig lambda chain V region 4A IGLV2-23(1-?) WIPF1 Ig kappa chain V-I region Walker IGLV4-60(1-?) Ig kappa chain V-III region NG9 Ig lambda chain V-III region SH PhosphatidatephosphataseIg kappa chain V-I region Gal Ig lambda chain V-II region MGC Ig kappa chain V-I region EU Ig heavy chain V-I region ND Ig kappa chain V-I region Rei CD247-1 Ig lambda chain V-II region NIG-58 Ig heavy chain V-II region NEWM IGHV(1-?) CD247-1 Ig kappa chain V-II region MIL Ig kappa chain V-I region AG Ig kappa chain V-III region B6 Ig lambda chain V-I region NIG-64 Ig lambda chain V-I region WAH IGLV4-60(1-?) Ig heavy chain V-III region NIE IGLV3-25(1-?) RAC1 ATPIg lambda chain V-VII region MOT Ig kappa chain V-III region WOL Ig lambda chain V-VI region WLT CDC42 Ig heavy chain V-III region POM Ig kappa chain V-I region CAR IGLC3 Ig heavy chain V-III region POM Ig kappa chain V-I region Gal Ig lambda chain V-VI region SUT Ig lambda chain V-II region MGC ACTG1 Ig kappa chain V-II region Cum ATPIg lambda chain V-I region MEM p-Y150-WASF2 Ig lambda chain V-VI region NIG-48 Ig kappa chain V-I region EU Ig heavy chain V-II region ARH-77 Ig kappa chain V-I region Gal IGKC Ig lambda chain V-IV region Hil Ig kappa chain V-III region CLL Ig heavy chain V-I region WOL Ig heavy chain V-II region HE RAC1:GTPIg lambda chain V region 4A BRK1 IGLV4-3(1-?) Ig kappa chain V-II region GM607 IgH heavy chain V-III region VH26 precursor Ig kappa chain V-I region Rei Ig lambda chain V-III region LOI PIK3CB Ig lambda chain V-VII region MOT Ig kappa chain V-II region TEW Ig lambda chain V-IV region Hil p-Y256-WASL IGLC7 IGLV7-43(1-?) IGLC1 p-S144,T423-PAK1 IGLV2-33(1-?) MYH9 Ig kappa chain V-III region B6 Ig heavy chain V-II region DAW Ig heavy chain V-II region OU IGLC3 Ig heavy chain V-III region POM IGHG1 Ig heavy chain V-II region SESS Ig heavy chain V-III region TUR p-Y151,S,T-WASF1 Ig heavy chain V-III region TEI Ig kappa chain V-II region RPMI 6410 Ig kappa chain V-III region VH IGLV4-60(1-?) Ig kappa chain V-I region Roy Ig lambda chain V-III region SH Src-kinasesIg heavy chain V-III region TRO IGHG3 Ig heavy chain V-II region MCE Ig lambda chain V-III region LOI Ig kappa chain V-III region VH Ig kappa chain V-I region Walker IGLV3-16(1-?) IGLV11-55(1-?) Ig kappa chain V-I region DEE PI(3,4,5)P3Ig heavy chain V-I region SIE Ig kappa chain V-III region HIC Ig kappa chain V-I region Rei Ig kappa chain V-III region VG p-Y288,Y304-FCGR2A Ig lambda chain V-I region NEWM ADP IGLV8-61(1-?) GRB2-1 IGLC2 PI(4,5)P2 ATPBRK1 Ig kappa chain V-III region Ti IGHG3 IGLV4-60(1-?) PI(4,5)P2 Ig kappa chain V-I region Lay Ig kappa chain V-I region Scw Ig lambda chain V-I region HA p-Y256-WASL Ig heavy chain V-III region WAS Ig kappa chain V-III region WOL Ig kappa chain V-III region HAH Ig lambda chain V-I region NIG-64 IgH heavy chain V-III region VH26 precursor IGKVA18(21-?) Ig lambda chain V-III region LOI Ig heavy chain V-III region NIE Ig heavy chain V-I region HG3 Ig lambda chain V-IV region X IGLV2-23(1-?) Ig kappa chain V-I region OU Ig kappa chain V-IV region JI Ig heavy chain V-III region DOB IGKVA18(21-?) IGLV3-25(1-?) Ig heavy chain V-III region KOL Ig kappa chain V-I region AU Ig lambda chain V-II region VIL GDP PIK3R2 FCGR3A Antigen Ig kappa chain V-I region Ka WASF1 GTP Ig kappa chain V-I region AG Ig kappa chain V-I region CAR Ig lambda chain V-VI region EB4 ABI1 ATP Ig lambda chain V-I region BL2 Ig kappa chain V-IV region STH Ig heavy chain V-III region BUR IGHG2 ACTR2 CDC42 Ig lambda chain V-I region EPS Ig kappa chain V-III region HIC IGLV3-16(1-?) Ig lambda chain V-IV region MOL Ig lambda chain V-III region LOI IGLV3-27(1-?) p-Y288,Y304-FCGR2A Ig lambda chain V-I region NEW Actin filament boundMyosin-XIg heavy chain V-III region DOB Ig lambda chain V-II region MGC SYKIGHG1 Ig kappa chain V-I region Lay Ig kappa chain V-I region Mev Ig kappa chain V-I region Ni Ig lambda chain V-IV region Hil Ig kappa chain V-I region AU IGLV1-44(1-?) IGHG1 Ig kappa chain V-I region Hau IGLV4-3(1-?) Ig lambda chain V-I region MEM IGLV7-43(1-?) IGLV4-60(1-?) IGLV1-44(1-?) Ig lambda chain V-II region NEI Ig kappa chain V-I region Bi PAK1DAGsIg kappa chain V-I region OU Ig heavy chain V-III region JON WIPF3 IGLV3-16(1-?) Ig lambda chain V-II region WIN Ig kappa chain V-I region Hau IGLC7 Ig lambda chain V-II region WIN Ig heavy chain V-III region TIL LYN ACTR3 Ig lambda chain V-II region TOG Ig lambda chain V-I region VOR ATP Ig lambda chain V-VI region SUT Ig kappa chain V-I region Ka Ig kappa chain V-III region SIE BTK Ig kappa chain V-III region GOL Ig lambda chain V-IV region Kern Ig kappa chain V-I region Bi MYO10 ABI1 Ig heavy chain V-II region WAH Ig heavy chain V-III region KOL Ig lambda chain V-VI region NIG-48 Ig kappa chain V-I region Mev Ig kappa chain V-I region Bi IGLV1-36(1-?) Ig heavy chain V-II region DAW Ig lambda chain V-VI region EB4 Ig heavy chain V-III region TRO Ig heavy chain V-I region HG3 Ig kappa chain V-II region RPMI 6410 IGHG2 Ig kappa chain V-I region Walker Ig lambda chain V-I region NEWM ABI2 Ig heavy chain V-III region TEI Ig heavy chain V-III region WEA IGHG1 Ig kappa chain V-II region MIL NCKIPSD IGLV1-44(1-?) Ig heavy chain V-III region NIE Ig heavy chain V-II region MCE Ig heavy chain V-III region BUT PLD4 Ig kappa chain V-III region VH Ig lambda chain V-II region NIG-84 IGHG1 Ig kappa chain V-I region Gal Ig kappa chain V-I region BAN Ig kappa chain V-I region Lay WASF3 Ig kappa chain V-IV region JI Ig heavy chain V-III region TIL ITPR3 Ig kappa chain V-I region Rei Ig lambda chain V-II region NIG-58 Ig heavy chain V-II region HE IGLV3-25(1-?) IGKC Ig lambda chain V-I region WAH ATPIg kappa chain V-II region FR p-Y753,Y759,Y1217-PLCG2 Ig lambda chain V-VII region MOT IGHG3 WIPF1 ADP CYFIP1 Ig kappa chain V-III region HAH Ig lambda chain V-II region VIL Ig heavy chain V-III region KOL WIPF2 CYFIP1 Ig lambda chain V-I region WAH Ig heavy chain V-III region WAS Ig kappa chain V-II region FR Ig heavy chain V-III region BRO Ig heavy chain V-II region DAW IGLV5-37(1-?) IGKV4-1(21-?) Ig heavy chain V-III region BUT Ig lambda chain V-IV region Bau IGLV4-69(1-?) IGLV1-40(1-?) Ig lambda chain V-III region SH Ig heavy chain V-III region KOL Ig kappa chain V-I region Hau Ig lambda chain V-II region TRO IGHG3 IGLV3-25(1-?) Ig heavy chain V-III region JON Ig heavy chain V-III region NIE Ig kappa chain V-I region Gal Ig kappa chain V-II region TEW Ig lambda chain V-VI region EB4 Ig kappa chain V-III region VG IGLV3-27(1-?) Ig lambda chain V-II region MGC Ig lambda chain V-VI region AR PI(3,4,5)P3 Ig heavy chain V-III region BRO Ig kappa chain V-I region Mev IGLV2-33(1-?) IGLV1-36(1-?) Ig lambda chain V-I region NEW Ig heavy chain V-III region WEA Ig kappa chain V-III region IARC/BL41 IGLV8-61(1-?) IGLV2-18(1-?) Ig kappa chain V-II region Cum BRK1 IgH heavy chain V-III region VH26 precursor CYFIP1 Ig kappa chain V-IV region Len Ig kappa chain V-I region Bi ELMO2 F-actinIg heavy chain V-III region BUR IGLV1-44(1-?) IGLC3 Ig lambda chain V-V region DEL Ig kappa chain V-I region WAT IGLV3-12(1-?) Ig kappa chain V-I region Rei IGLV3-16(1-?) Ig kappa chain V region EV15 IGHG3 PI(4,5)P2 Ig heavy chain V-III region BUR p-Y151,S,T-WASF1 Ig kappa chain V-I region HK101 Ig kappa chain V-I region Lay Ig kappa chain V-I region Scw PAK1 Ig kappa chain V-II region RPMI 6410 Ig heavy chain V-III region WAS Ig lambda chain V-II region NIG-84 p-Y753,Y759,Y1217-PLCG2 Ig heavy chain V-I region Mot Ig heavy chain V-II region ARH-77 Ig heavy chain V-III region LAY Ig kappa chain V-III region HIC Ig lambda chain V-I region BL2 CDC42:GTP, RAC1:GTPIg kappa chain V-III region CLL NCKAP1 Ig kappa chain V-IV region Len Ig kappa chain V-III region POM Ig kappa chain V-II region TEW Ig heavy chain V-III region GAL Ig lambda chain V-IV region MOL BAIAP2 IGLV5-45(1-?) Ig lambda chain V-IV region MOL Ig kappa chain V-IV region JI Ig heavy chain V-I region WOL Ig kappa chain V-I region Scw IGHG3 Ig kappa chain V-I region Hau IgH heavy chain V-III region VH26 precursor Ig kappa chain V-III region HAH Ig heavy chain V-III region LAY IGKV1-5(23-?) Ig lambda chain V-II region NIG-84 Ig heavy chain V-II region NEWM Ig kappa chain V-II region Cum NCK1 Ig kappa chain V-I region WEA IGHV7-81(1-?) Ig lambda chain V-VI region SUT Ig lambda chain V-V region DEL Ig kappa chain V-III region HAH WIPF2 Ig lambda chain V region 4A IgG-Ag:FCGRIIIA:CD3G/CD3Z dimersIg lambda chain V-II region BOH Ig lambda chain V-VI region AR FCGR3A ARPC1A Ig kappa chain V-III region VH Ig lambda chain V-II region BUR Ig heavy chain V-I region HG3 CYFIP1 Ig lambda chain V-II region BUR Ig lambda chain V-IV region Kern Ig heavy chain V-III region TIL WIPF1 Ig lambda chain V-IV region Bau Ig lambda chain V-IV region Bau Ig heavy chain V-III region BUR Ig heavy chain V-II region WAH IGLV3-27(1-?) p-T508-LIMK1BRK1 Ig lambda chain V-I region NEW CYFIP1 IGLV(23-?) IGHV(1-?) IGLV5-37(1-?) IGLV1-44(1-?) GTP IGLV5-45(1-?) Ig lambda chain V-VI region EB4 N-WASP IGLV3-25(1-?) WIPF3 Ig kappa chain V-I region WAT Ig kappa chain V-III region CLL Ig kappa chain V-I region HK101 Ig heavy chain V-III region GA IGLV(23-?) Antigen IGLV3-12(1-?) Ig heavy chain V-III region TEI IGLV7-46(1-?) Ig kappa chain V-I region EU BAIAP2 Ig heavy chain V-I region SIE Ig lambda chain V-III region SH CDC42 p-Y151,S,T-WASF1 Ig heavy chain V-I region Mot Ig heavy chain V-III region JON Ig kappa chain V-III region HAH ARPC4 Ig kappa chain V-I region Roy Ig heavy chain V-II region COR WIPF3 IGLV(23-?) NCKIPSD Ig kappa chain V-III region VH FCGR1A Ig kappa chain V-II region FR BRK1 Ig heavy chain V-II region WAH IGLV(23-?) Ig kappa chain V-I region Lay Ig kappa chain V-III region VG Ig lambda chain V-I region NIG-64 Ig kappa chain V-III region SIE Ig lambda chain V-I region NIG-64 Ig kappa chain V-I region HK101 Ig kappa chain V-I region Daudi p-Y150,S343,T346-WASF2 Ig kappa chain V-III region B6 ACTG1 Ig lambda chain V-II region NEI Ig heavy chain V-II region DAW Ig lambda chain V-III region SH Ig kappa chain V-III region VG Ig kappa chain V-IV region B17 clusteredIgG-Ag:p-FCGRsIg lambda chain V-I region BL2 Ig lambda chain V-I region NIG-64 IGLV3-22(1-?) Ig lambda chain V-VI region SUT Ig kappa chain V-II region GM607 IGKV4-1(21-?) IGLV8-61(1-?) HSP90AA1 Ig kappa chain V-III region B6 Ig kappa chain V-I region Rei CYFIP1 Ig kappa chain V-I region DEE RAC1 Ig lambda chain V-III region SH Ig heavy chain V-I region Mot Ig kappa chain V-I region Rei Ig heavy chain V-III region DOB ARPC2 Ig lambda chain V-VI region WLT VAV1 p-Y291-WAS Ig heavy chain V-III region NIE Ig heavy chain V-III region JON Ig heavy chain V-III region KOL Ig heavy chain V-II region OU Ig lambda chain V-II region BUR IGHG2 Antigen Ig heavy chain V-III region WAS Ig kappa chain V-I region Kue Ig kappa chain V-II region Cum Ig lambda chain V-I region WAH IGKC VAV1 Ig kappa chain V-I region Lay IGHG3 NCKIPSD Ig heavy chain V-III region KOL Ig kappa chain V-III region WOL IGLC1 Ig heavy chain V-I region SIE IGLV4-69(1-?) Ig kappa chain V-IV region STH p-5S-ABI1 IGHV7-81(1-?) Antigen Ig lambda chain V-II region NIG-84 IGLV1-36(1-?) Ig heavy chain V-III region TUR Ig lambda chain V-I region BL2 IGLV4-3(1-?) Ig heavy chain V-II region DAW IGLV7-46(1-?) Ig kappa chain V-III region WOL Ig lambda chain V-II region BUR Ig lambda chain V-II region MGC IGHG3 Ig kappa chain V-III region VG Ig lambda chain V-II region NEI Ig kappa chain V-II region FR IGHG2 Ig kappa chain V-III region WOL IGLV2-11(1-?) Ig kappa chain V-II region RPMI 6410 PLDIg kappa chain V-I region CAR IGLV4-60(1-?) IGLC6 Ig heavy chain V-II region OU IGLV2-18(1-?) p-5S-ABI1 Ig kappa chain V-I region AG Ig heavy chain V-III region NIE IGLC7 Ig kappa chain V-I region Daudi Ig kappa chain V-I region Gal Ig kappa chain V-II region RPMI 6410 Ig lambda chain V-II region VIL Ig kappa chain V-I region HK101 HCK Ig kappa chain V-I region Ka LIMK1ELMO1 Ig heavy chain V-II region WAH IGHG1 IGLV1-40(1-?) IGLV3-12(1-?) Ig lambda chain V-VI region EB4 p-Y150,S343,T346-WASF2 IGHV(1-?) Ig lambda chain V-II region NEI Ig lambda chain V-IV region Bau Ig lambda chain V-II region TOG Ig heavy chain V-I region WOL Ig heavy chain V-III region TRO Ig heavy chain V-III region KOL IGLV(23-?) ATPIg kappa chain V-I region BAN IgH heavy chain V-III region VH26 precursor Ig kappa chain V-III region SIE Ig kappa chain V-IV region JI Ig heavy chain V-II region SESS IGLV4-3(1-?) IGLV10-54(1-?) Ig lambda chain V-I region NEW Ig lambda chain V-IV region Bau Ig kappa chain V-IV region Len Ig lambda chain V-IV region MOL IGHG1 Antigen Ig lambda chain V-II region TOG Ig lambda chain V-I region HA Ig heavy chain V-III region DOB Ig heavy chain V-III region TIL Ig kappa chain V-I region Kue Ig kappa chain V-III region HIC IGLV2-18(1-?) PRKCD Ig kappa chain V-III region VG Ig lambda chain V-II region BOH Ig lambda chain V-II region NEI Ig kappa chain V-III region B6 Ig lambda chain V-V region DEL Ig lambda chain V-I region NEWM Ig lambda chain V-VII region MOT IGLV10-54(1-?) Ig kappa chain V-I region BAN Ig kappa chain V-I region Hau Ig kappa chain V-IV region JI IGLV5-45(1-?) Ig heavy chain V-III region BRO Ig kappa chain V-III region VG Ig lambda chain V-II region NIG-58 IGLV3-16(1-?) IGLV5-45(1-?) Ig kappa chain V-I region Roy IGHG2 Ig heavy chain V-II region WAH G-actinATPIg lambda chain V-I region MEM Ig lambda chain V-II region VIL Ig heavy chain V-I region EU Ig kappa chain V-III region SIE IGLV2-18(1-?) IGLV1-40(1-?) ARPC3 Ig lambda chain V-II region BO Ig heavy chain V-III region BUR Ig heavy chain V-II region NEWM IGLV3-25(1-?) Ig heavy chain V-III region WAS ARPC3 Ig lambda chain V-III region SH Ig kappa chain V-I region Ni ACTB(1-375) Ig heavy chain V-III region CAM IGLV3-12(1-?) Ig heavy chain V-III region POM H2OIGLC3 Ig heavy chain V-III region NIE Ig lambda chain V-VI region NIG-48 GTP Ig heavy chain V-III region POM IGLV3-27(1-?) Ig lambda chain V-IV region Hil IgH heavy chain V-III region VH26 precursor Ig heavy chain V-III region CAM WRC:IRSp53/58:RAC1:GTP:PIP3Ig lambda chain V-II region BO ARPC2 IGLC1 WIPF3 Ig kappa chain V-III region VG Ig kappa chain V-IV region Len Ig kappa chain V-I region Kue Ig kappa chain V-I region Rei Ig heavy chain V-III region WAS GTP Ig heavy chain V-III region TIL FCGR3A Ig kappa chain V-I region Kue IGLV2-33(1-?) Ig heavy chain V-III region GAL IGLV(23-?) Ig heavy chain V-II region ARH-77 IGLV4-3(1-?) Ig kappa chain V-II region Cum Ig lambda chain V-I region VOR Ig kappa chain V-III region GOL Ig kappa chain V-IV region STH Ig lambda chain V-I region EPS IGHG3 Ig heavy chain V-III region GAL Ig lambda chain V-I region NEWM Ig lambda chain V-I region VOR CDC42:GTPFCGR3A p-6Y-CD247-1 IGLV3-12(1-?) IGKV4-1(21-?) Ig heavy chain V-III region TEI IGLV2-23(1-?) Ig kappa chain V-I region BAN p-Y160,Y171-CD3G Ig kappa chain V-I region Walker Ig kappa chain V-II region RPMI 6410 Ig lambda chain V-VI region NIG-48 IGKVA18(21-?) Ig lambda chain V-II region NIG-58 IGLC7 Ig lambda chain V-VI region EB4 YES1 Ig kappa chain V-III region NG9 FCGR3A IGLV3-25(1-?) Ig lambda chain V-VII region MOT ACTR2 Ig lambda chain V-II region NIG-58 IGHG1 CDC42 IGKV4-1(21-?) Ig kappa chain V-I region BAN Ig lambda chain V-I region NEW Ig kappa chain V-I region AU Ig kappa chain V-IV region Len Ig heavy chain V-I region SIE Ig kappa chain V-III region POM Ig heavy chain V-II region MCE Ig heavy chain V-III region DOB Ig lambda chain V-VI region EB4 Ig lambda chain V-I region WAH Ig heavy chain V-I region WOL IGLV3-22(1-?) Ig heavy chain V-I region Mot Ig kappa chain V-III region B6 Ig kappa chain V-III region VH BRK1 Ig heavy chain V-III region TRO IGHG2 p-6Y-CD247-1 Ig lambda chain V region 4A ABI1 Ig kappa chain V-III region WOL Ig kappa chain V-III region HAH I(1,4,5)P3 IGLC2 Antigen IGLV5-37(1-?) Ig lambda chain V-III region LOI Ig heavy chain V-III region BUR IGLV7-43(1-?) Ig heavy chain V-II region SESS Ig kappa chain V-III region VH IGLV3-12(1-?) Ig kappa chain V-I region Scw Ig kappa chain V-I region WAT IGLV4-69(1-?) IGLV(23-?) Ig lambda chain V-VI region WLT Ig lambda chain V-I region EPS Ig lambda chain V-III region SH MYO1C Ig lambda chain V-VI region WLT Ig lambda chain V-V region DEL IGLV1-36(1-?) Ig lambda chain V-IV region X IGLV2-11(1-?) Ig kappa chain V-I region Lay Ig heavy chain V-I region EU Ig heavy chain V-II region DAW Ig kappa chain V-III region IARC/BL41 Ig heavy chain V-III region DOB Ig kappa chain V region EV15 Ig lambda chain V-I region MEM Ig lambda chain V-II region TOG Ig heavy chain V-II region NEWM IGLV11-55(1-?) Ig kappa chain V-I region Ni ARPC1A Ig lambda chain V-IV region MOL IGLV2-23(1-?) IGLV10-54(1-?) IGLV5-45(1-?) Ig kappa chain V-I region BAN Ig lambda chain V-VI region WLT Ig lambda chain V-II region BO PiIg kappa chain V-IV region JI Ig kappa chain V-I region Wes p-Y160,Y171-CD3G Ig lambda chain V region 4A Ig heavy chain V-II region OU Ig kappa chain V-II region MIL Ig lambda chain V-III region LOI Ig kappa chain V-II region MIL Ig kappa chain V-I region Wes IGHV(1-?) Ig heavy chain V-II region HE Ig lambda chain V-I region HA IGHV(1-?) I(1,4,5)P3 Ig lambda chain V-II region BOH NCK1 PLD3 IGLC1 Ig kappa chain V-IV region Len Ig heavy chain V-III region POM Ig lambda chain V-II region BO IGLV2-23(1-?) IGKV4-1(21-?) Ig kappa chain V-I region Roy Ig lambda chain V-II region NEI Ig lambda chain V-IV region Hil Ig heavy chain V-III region KOL IGLV4-3(1-?) Ig kappa chain V-II region TEW Ig kappa chain V-I region BAN IGLV7-46(1-?) Ig lambda chain V-II region WIN Ig lambda chain V-II region BUR Ig lambda chain V-II region BO Ig heavy chain V-III region GA Ig heavy chain V-II region MCE Ig kappa chain V-I region Scw Ig kappa chain V-II region FR IGLC7 IGKV4-1(21-?) IGLC7 Ig heavy chain V-I region EU ITPR1 Ig kappa chain V-III region POM IGLV8-61(1-?) IGLV10-54(1-?) Ig kappa chain V-II region MIL Ig heavy chain V-III region TRO Ig heavy chain V-I region ND Ig heavy chain V-I region EU Ig lambda chain V-I region VOR IGLC2 IGKV1-5(23-?) Ig kappa chain V-III region SIE Ig heavy chain V-II region HE IGLC7 IGLC6 IGLV7-43(1-?) Ig heavy chain V-II region ARH-77 I(1,4,5)P3Ig kappa chain V-III region IARC/BL41 Ig heavy chain V-III region POM Ig kappa chain V-I region Ni Ig heavy chain V-I region Mot MYH2 Ig lambda chain V-VI region EB4 Ig kappa chain V-III region B6 IGHG2 Ig kappa chain V-I region EU Ig heavy chain V-II region ARH-77 Ig heavy chain V-III region LAY p-Y151,S,T-WASF3 Ig kappa chain V-I region CAR Ig lambda chain V-II region NIG-58 Ig heavy chain V-III region GAL IGHG1 Ig lambda chain V-III region LOI Ig lambda chain V-II region TRO ITPR2 Ig kappa chain V-IV region STH Ig heavy chain V-III region BUR IGLV2-33(1-?) Ig kappa chain V-I region Hau Ig lambda chain V-I region WAH Ig lambda chain V-VI region NIG-48 ATP Ig kappa chain V-I region WAT Ig heavy chain V-III region GAL p-Y256-WASL IGLV3-25(1-?) IgH heavy chain V-III region VH26 precursor Ig kappa chain V-I region Bi Ig kappa chain V-III region CLL Ig kappa chain V-I region Kue IGKVA18(21-?) Ig lambda chain V-II region NEI Ig kappa chain V-III region GOL IGHV7-81(1-?) Ig lambda chain V-II region WIN Ig heavy chain V-III region KOL IGLV5-45(1-?) Ig kappa chain V-III region B6 PI(4,5)P2 Ig kappa chain V-IV region Len IGLV2-18(1-?) IGLV3-25(1-?) Ig heavy chain V-III region BUR IGHG3 IGLV3-25(1-?) IGLV5-45(1-?) IGLV3-12(1-?) Ig heavy chain V-III region WEA Ig lambda chain V-VII region MOT Ig kappa chain V-I region Kue RAC1 p-Y160,Y171-CD3G Ig kappa chain V-IV region JI IGLV1-40(1-?) Ig kappa chain V-I region DEE PI3K:p-6Y-SYKIg kappa chain V-I region Scw Ig heavy chain V-II region SESS CYFIP2 GTP ACTR2 IGLV4-3(1-?) IGLC1 Ig lambda chain V-I region VOR Ig lambda chain V-IV region MOL Ig heavy chain V-II region HE Ig heavy chain V-III region JON Ig heavy chain V-III region LAY Ig heavy chain V-II region SESS Ig kappa chain V-I region CAR IGLV11-55(1-?) Ig kappa chain V-II region Cum IGLV5-45(1-?) p-Y291-WAS Ig kappa chain V-II region FR Ig heavy chain V-I region SIE Ig kappa chain V-IV region STH PI3KclusteredIgG-Ag:p-FCGRsp-Y288,Y304-FCGR2A ATP p-Y151,S,T-WASF3 IGHV(1-?) Ig kappa chain V-III region HAH Ig heavy chain V-II region ARH-77 Ig kappa chain V-I region Scw Ig kappa chain V-I region Kue Ig heavy chain V-III region WAS PI(4,5)P2ARPC4 IGKVA18(21-?) p-Y160,Y171-CD3G Ig lambda chain V-III region SH IGHG2 IGLC3 Ig kappa chain V-IV region Len Ig heavy chain V-III region BUT Motherfilament:branchingcomplexIGLV1-40(1-?) Ig heavy chain V-III region TRO Ig lambda chain V-VI region WLT Ig lambda chain V-I region BL2 Ig kappa chain V-I region Ni Ig kappa chain V-I region DEE Ig kappa chain V-IV region STH Ig kappa chain V-III region SIE Ig heavy chain V-III region WAS Ig lambda chain V-II region NIG-84 Ig heavy chain V-II region NEWM Ig heavy chain V-II region MCE Ig lambda chain V-I region NEW Ig heavy chain V-III region ZAP p-Y151-WASF1 Antigen IGLV2-11(1-?) Ig kappa chain V-II region FR BAIAP2IGHG2 ACTR2 IGHG4 Ig kappa chain V-I region Ka Ig kappa chain V-III region VG Ig heavy chain V-III region ZAP GTP Ig heavy chain V-III region BUT IGHV7-81(1-?) Ig kappa chain V-I region Lay Ig heavy chain V-III region GA BAIAP2 Ig heavy chain V-I region WOL IGLV4-69(1-?) Ig lambda chain V-II region VIL ITPR1 Ig lambda chain V-II region BOH NCKAP1L IGHG2 Antigen ATP Ig heavy chain V-II region COR Ig lambda chain V-IV region X Ig heavy chain V-II region NEWM Ig lambda chain V-II region NIG-84 IGHG2 IGKV1-5(23-?) IGKV1-5(23-?) Ig kappa chain V-III region GOL Ig lambda chain V-II region NEI Ig lambda chain V-VI region NIG-48 IGHG1 Ig kappa chain V-I region AU IGLV2-11(1-?) ABI1 Ig heavy chain V-III region GA Ig lambda chain V-I region NEW CD247-1 Ig heavy chain V-III region NIE Ig lambda chain V-IV region Kern p-Y150,S343,T346-WASF2 Ig kappa chain V region EV15 Ig lambda chain V-I region VOR BAIAP2 MYO5A Ig lambda chain V-VI region AR IGLV1-44(1-?) WIPF1 Ig lambda chain V-IV region MOL Ig heavy chain V-I region EU Ig heavy chain V-I region HG3 Ig heavy chain V-III region TUR Ig kappa chain V-IV region B17 Ig lambda chain V-IV region Bau Ig kappa chain V-I region CAR Ig lambda chain V-I region EPS Ig kappa chain V-III region GOL Ig heavy chain V-II region WAH IGLV11-55(1-?) Ig lambda chain V-IV region Hil Ig kappa chain V-I region Ni IGLV2-33(1-?) IGLV(23-?) WASF3 Ig heavy chain V-III region HIL VAV2 Ig kappa chain V-III region GOL Ig kappa chain V-III region POM Ig kappa chain V-III region CLL RAC1 IGKV1-5(23-?) clusteredIgG-Ag:p-FCGRs:p-6Y-SYK:p-VAVIg heavy chain V-III region HIL Ig kappa chain V-I region OU Ig kappa chain V-III region POM Ig heavy chain V-III region BRO IGKC Ig kappa chain V-I region Hau Ig lambda chain V-III region LOI Ig heavy chain V-III region TUR ADPIg lambda chain V-III region LOI Ig heavy chain V-III region TRO Ig kappa chain V-I region Daudi IGLC1 IGKV4-1(21-?) Ig kappa chain V-III region GOL PiIg lambda chain V-II region BUR Ig kappa chain V-III region NG9 Ig heavy chain V-III region WEA CYFIP2 p-S,T508-LIMK1 IGLV7-43(1-?) IGLV11-55(1-?) Ig heavy chain V-III region BRO Ig kappa chain V-I region Roy IGLV2-23(1-?) Ig lambda chain V-I region HA GRB2-1 Ig lambda chain V-II region BOH IGLV4-3(1-?) Ig heavy chain V-II region ARH-77 IGLV1-44(1-?) IGLV3-25(1-?) FCGR3A Ig kappa chain V-II region FR Ig heavy chain V-II region OU Ig kappa chain V-I region Ni WASF2 Ig lambda chain V-II region MGC IGLV11-55(1-?) Ig kappa chain V-IV region STH IGLV(23-?) Ig lambda chain V-VI region NIG-48 Ig lambda chain V-II region NIG-84 Ig heavy chain V-II region NEWM F-actin Ig kappa chain V-III region WOL IGKV4-1(21-?) Ig kappa chain V-II region RPMI 6410 ELMO1 p-Y288,Y304-FCGR2A Ig kappa chain V-I region Ni Ig kappa chain V-III region GOL IGKV4-1(21-?) Ig lambda chain V-III region SH Ig lambda chain V-VI region SUT IGLV2-23(1-?) Ig kappa chain V-I region OU Ig heavy chain V-I region ND IGLV3-12(1-?) IGLV4-69(1-?) Ig heavy chain V-III region TRO Ig lambda chain V-I region BL2 Ig lambda chain V-I region BL2 NCKAP1 Ig heavy chain V-II region OU Ig kappa chain V-I region WAT PiIg kappa chain V-I region BAN p-Y288,Y304-FCGR2A Ig kappa chain V-I region Bi Ig heavy chain V-I region ND Ig heavy chain V-III region ZAP IGLV2-18(1-?) Ig heavy chain V-III region GAL Ig heavy chain V-III region DOB Ig heavy chain V-III region HIL Ig lambda chain V-II region TRO NCK1 IGLC1 IGKVA18(21-?) DOCK1 p-Y150-WASF2 ITPR2 Ig kappa chain V-II region GM607 Ig heavy chain V-III region POM ARPC3 PLCG1 Ig lambda chain V-II region TRO p-Y291-WAS Ig heavy chain V-III region KOL Ig kappa chain V-II region TEW Antigen GRB2-1 IGLC1 Ig heavy chain V-II region HE Ig heavy chain V-III region GAL Ig lambda chain V-VII region MOT Ig kappa chain V-III region VG Ig lambda chain V-I region MEM ARPC1A Ig heavy chain V-II region OU DOCK1 IGLV7-43(1-?) Ig kappa chain V-III region VH H2OIGLV10-54(1-?) Ig kappa chain V-III region SIE Ig kappa chain V-I region Ni Ig lambda chain V-I region NEW Ig lambda chain V-VI region SUT GTP p-6Y-CD247-1 clusteredIgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCGIg kappa chain V-I region OU Ig lambda chain V-II region NIG-58 Ig heavy chain V-III region POM IGLC1 IGLV1-40(1-?) Ig kappa chain V-I region HK101 Ig kappa chain V-IV region STH Ig lambda chain V-VI region NIG-48 Ig heavy chain V-III region BRO p-4Y-PLCG1 IGLC6 Ig heavy chain V-III region DOB Ig kappa chain V-IV region STH Ig kappa chain V-IV region STH IGKC SRC-1 Ig kappa chain V-III region HAH Ig kappa chain V region EV15 Ig kappa chain V region EV15 IGKV1-5(23-?) Ig lambda chain V-III region SH Ig heavy chain V-III region CAM PI(3,4,5)P3 Ig heavy chain V-III region BRO ADPIGKV4-1(21-?) IGLC2 IGLV4-3(1-?) Ig heavy chain V-III region WAS Ig heavy chain V-III region WEA Ig heavy chain V-III region GA Ig kappa chain V-I region Ka Ig kappa chain V-III region VH Ig heavy chain V-III region CAM CD3G Ig kappa chain V-I region EU Ig heavy chain V-III region GA Ig kappa chain V-II region TEW p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3Ig kappa chain V-I region Lay Ig heavy chain V-III region GAL Ig lambda chain V-I region BL2 Ig kappa chain V-I region CAR IGKVA18(21-?) Ig kappa chain V-I region Lay Ig lambda chain V-II region WIN IGLC6 p-Y160,Y171-CD3G Ig heavy chain V-I region HG3 IGLV7-46(1-?) IGKVA18(21-?) p-6Y-CD247-1 Ig kappa chain V-I region AG Ig heavy chain V-III region BRO CD3G IGHV7-81(1-?) Ig lambda chain V-II region BOH NCKAP1 Ig lambda chain V-V region DEL Ig lambda chain V-II region TOG Ig kappa chain V-II region FR Ig kappa chain V-I region Scw Ig kappa chain V-I region Rei Ig kappa chain V-III region IARC/BL41 Ig kappa chain V-I region AU Ig kappa chain V-III region SIE Ig kappa chain V-III region VH WASP/N-WASPIg heavy chain V-II region COR CRK IGKVA18(21-?) Ig lambda chain V-I region NEWM Ig heavy chain V-I region Mot IGLC1 Ig heavy chain V-II region OU Ig lambda chain V region 4A Ig kappa chain V-III region CLL p-Y151,S,T-WASF3 NCKIPSD NCKIPSD Ig lambda chain V-VII region MOT Ig heavy chain V-I region HG3 Ig kappa chain V-I region CAR Ig kappa chain V-III region SIE p-5S-ABI1 ARPC1A Ig kappa chain V-I region Hau Ig kappa chain V region EV15 Ig lambda chain V-VI region WLT p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3IGLV2-11(1-?) IGLC3 Ig heavy chain V-III region TEI Ig kappa chain V-III region IARC/BL41 CDC42 Ig kappa chain V-I region CAR p-6Y-SYK Ig heavy chain V-III region BUT IGLV3-27(1-?) Ig heavy chain V-II region COR Ig kappa chain V-I region Bi IGLV2-23(1-?) Ig kappa chain V-I region BAN Ig lambda chain V-I region NEWM ABI1 IGLC7 Ig kappa chain V-IV region Len AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramerIg lambda chain V-I region VOR Ig lambda chain V-II region VIL Ig kappa chain V-III region HIC Ig heavy chain V-III region BUT Ig kappa chain V-I region AG FCGR2A IGLV4-60(1-?) IGLV3-27(1-?) p-6Y-CD247-1 GTP Ig lambda chain V-I region VOR Ig kappa chain V-II region GM607 Ig lambda chain V-V region DEL Antigen Ig heavy chain V-I region EU Ig kappa chain V-I region Rei NCKAP1L Ig kappa chain V-II region GM607 ACTR3 ARPC1A IGLC3 Ig lambda chain V-III region LOI Ig heavy chain V-III region BUR N-WASP IGLV4-69(1-?) Ig lambda chain V-II region NIG-84 Ig kappa chain V-III region Ti Ig heavy chain V-III region CAM IGLV8-61(1-?) Ig kappa chain V-I region Wes Antigen Ig lambda chain V-II region NIG-58 CRK:DOCK180:ELMO1,ELMO2GTP Ig heavy chain V-III region CAM Ig heavy chain V-III region GA p-Y151-WASF3 IGLV1-36(1-?) IGKC ARPC5 ABL1Ig kappa chain V-II region MIL ACTR3 Ig kappa chain V-I region Mev Ig kappa chain V-I region Roy ACTG1 Ig heavy chain V-III region TEI PLCG2 Ig heavy chain V-III region WEA Ig lambda chain V-VI region WLT IGLV2-23(1-?) CYFIP2 IGLV4-60(1-?) Ig heavy chain V-III region BUR PI(4,5)P2 Ig kappa chain V-I region Ka p-4S-ABI2 Ig heavy chain V-III region DOB Ig kappa chain V-I region DEE p-Y150,S343,T346-WASF2 Ig heavy chain V-III region DOB Ig kappa chain V-IV region Len IGHV(1-?) Ig kappa chain V-III region HIC Ig lambda chain V-VI region SUT Ig lambda chain V-VII region MOT Ig kappa chain V-I region Lay p-T507,S645,S664-PRKCD(1-676) PIK3CA Ig kappa chain V-III region WOL NCKAP1 Ig heavy chain V-III region BUR FCGR1A p-Y256-WASL Ig kappa chain V-II region GM607 IGHG2 Ig kappa chain V-I region Ni Ig heavy chain V-III region TUR IGLV4-60(1-?) Ig kappa chain V-III region NG9 Myosin-X dimerIGLV(23-?) FCGR3A ACTB(1-375) IGLV7-46(1-?) IGLV2-11(1-?) IGLV4-69(1-?) Ig kappa chain V-II region Cum Ig lambda chain V-IV region Kern ACTR2 Ig kappa chain V-IV region B17 Ig kappa chain V-III region Ti Ig heavy chain V-III region LAY IGLV1-40(1-?) IGLC3 Ig kappa chain V-III region IARC/BL41 Ig heavy chain V-III region TIL WIPF1 Ig kappa chain V-I region Ka Ig heavy chain V-II region HE Ig lambda chain V-I region MEM clusteredIgG-Ag:FCGRsIg lambda chain V-II region MGC Ig heavy chain V-I region Mot IGLV2-33(1-?) Ig lambda chain V-I region NIG-64 Ig heavy chain V-III region BRO NCKAP1 NCK1 Ig kappa chain V-III region B6 IGHG4 Ig heavy chain V-II region ARH-77 IGKV4-1(21-?) p-Y151-WASF3 Ig kappa chain V-III region IARC/BL41 BAIAP2 Ig kappa chain V-I region Bi BRK1 p-S3-CFL1 Ig lambda chain V-VI region EB4 Ig heavy chain V-III region CAM Ig heavy chain V-II region DAW Ig lambda chain V-VI region WLT Ig lambda chain V-I region EPS Ig heavy chain V-III region CAM Ig heavy chain V-III region POM Ig lambda chain V-VI region AR Ig kappa chain V-III region NG9 Ig lambda chain V-IV region Hil Ig kappa chain V-I region AU Ig kappa chain V-I region Mev Ig heavy chain V-III region WEA Ig heavy chain V-III region WEA Ig heavy chain V-II region ARH-77 Ig heavy chain V-III region BRO Ig kappa chain V-I region Hau Ig heavy chain V-II region HE Ig kappa chain V-II region GM607 GTP IGLC1 MYH2 Ig kappa chain V-III region HIC IGLC6 Ig kappa chain V-II region MIL Ig kappa chain V-I region Mev IGHG1 Ig heavy chain V-III region JON IGLV3-27(1-?) p-Y291-WAS Ig lambda chain V-IV region Hil CYFIP2 Ig lambda chain V-VI region WLT Ig lambda chain V-VI region AR Ig kappa chain V-III region B6 Src family kinases(SFKs)IGKC IGHV(1-?) Ig lambda chain V-I region VOR IGLV4-69(1-?) Ig heavy chain V-II region WAH Ig heavy chain V-II region NEWM p-T202,Y204-MAPK3 Ig lambda chain V-V region DEL Ig heavy chain V-III region JON Ig lambda chain V-II region BUR ACTG1 Ig kappa chain V-I region Walker Ig heavy chain V-I region WOL Ig heavy chain V-I region ND NCKAP1L Ig lambda chain V-II region BUR p-Y174-VAV1 WIPF1 Ig kappa chain V-I region Wes GRB2-1 IGLV3-16(1-?) Ig lambda chain V-I region HA Ig kappa chain V-III region WOL Ig kappa chain V-I region AU ARPC1B Ig kappa chain V-III region IARC/BL41 Ig heavy chain V-I region ND Ig heavy chain V-III region ZAP Ig kappa chain V-IV region STH IGLV7-46(1-?) Ig kappa chain V-III region HAH Ig lambda chain V-II region VIL Ig kappa chain V-I region Lay p-6Y-CD247-1 SH3 domain proteinsIg lambda chain V-II region MGC Ig lambda chain V-II region BUR Ig heavy chain V-III region LAY NCK1 Ig kappa chain V-I region AG ACTB(1-375) Ig lambda chain V-VI region SUT NCKIPSD Ig heavy chain V-II region NEWM Ig lambda chain V-I region NEW Ig kappa chain V-I region EU PI(4,5)P2 IgH heavy chain V-III region VH26 precursor Ig lambda chain V-II region BO GRB2-1 Ig heavy chain V-I region ND ITPR2 MYO10 Ig kappa chain V-III region NG9 Ig heavy chain V-III region TRO Ig lambda chain V-II region BUR Ig kappa chain V-I region Roy IGLV7-43(1-?) Ig heavy chain V-I region Mot ABI2 Ig kappa chain V-III region WOL Ig kappa chain V-III region WOL IGLV10-54(1-?) IGLV8-61(1-?) Ig kappa chain V-I region Rei Ig heavy chain V-II region ARH-77 Ig lambda chain V-I region BL2 IGKVA18(21-?) Ig kappa chain V-III region NG9 PKC-delta/epsilonACTG1 Antigen-antibodycomplexIg kappa chain V-III region VH IGHV7-81(1-?) Ca2+Ig kappa chain V-I region Hau Ig kappa chain V-III region NG9 IGHG1 GDPIGLV2-23(1-?) IGLV5-37(1-?) IGKV1-5(23-?) Ig kappa chain V-I region OU PCIg lambda chain V-VII region MOT Ig kappa chain V-I region OU p-Y256-WASL Ig lambda chain V-I region NEW Ig kappa chain V-III region Ti CFL1HSP90AA1,HSP90AB1ARPC4 Ig heavy chain V-III region POM Ig heavy chain V-II region MCE p-Y151,S,T-WASF3 IGLC6 p-S144,T423-PAK1Ig kappa chain V-II region FR Ig lambda chain V-IV region Kern Ig kappa chain V-III region NG9 Ig lambda chain V-II region BOH Ig lambda chain V-II region BUR Ig lambda chain V-VI region NIG-48 393131, 843931


Description

Phagocytosis is one of the important innate immune responses that function to eliminate invading infectious agents. Monocytes, macrophages, and neutrophils are the professional phagocytic cells. Phagocytosis is a complex process involving the recognition of invading foreign particles by specific types of phagocytic receptors and the subsequent internalization of the particles. Fc gamma receptors (FCGRs) are among the best studied phagocytic receptors that bind to Fc portion of immunoglobulin G (IgG). Through their antigen binding F(ab) end, antibodies bind to specific antigen while their constant (Fc) region binds to FCGRs on phagocytes. The clustering of FCGRs by IgG antibodies on the phagocyte initiates a variety of signals, which lead, through the reorganisation of actin cytoskeleton and membrane remodelling, to the formation of pseudopod and phagosome. Fc gamma receptors are classified into three classes: FCGRI, FCGRII and FCGRIII. Each class of these FCGRs consists of several individual isoforms. Among all these isoforms FCGRI, FCGRIIA and FCGRIIIA, are able to mediate phagocytosis (Joshi et al. 2006, Garcia Garcia & Rosales 2002, Nimmerjahn & Ravetch 2006). View original pathway at:Reactome.

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Bibliography

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  58. Rohatgi R, Nollau P, Ho HY, Kirschner MW, Mayer BJ.; ''Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway.''; PubMed Europe PMC Scholia
  59. Li R, Soosairajah J, Harari D, Citri A, Price J, Ng HL, Morton CJ, Parker MW, Yarden Y, Bernard O.; ''Hsp90 increases LIM kinase activity by promoting its homo-dimerization.''; PubMed Europe PMC Scholia
  60. Miki H, Suetsugu S, Takenawa T.; ''WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac.''; PubMed Europe PMC Scholia
  61. Chong C, Tan L, Lim L, Manser E.; ''The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity.''; PubMed Europe PMC Scholia
  62. Nakanishi O, Suetsugu S, Yamazaki D, Takenawa T.; ''Effect of WAVE2 phosphorylation on activation of the Arp2/3 complex.''; PubMed Europe PMC Scholia
  63. Corrotte M, Chasserot-Golaz S, Huang P, Du G, Ktistakis NT, Frohman MA, Vitale N, Bader MF, Grant NJ.; ''Dynamics and function of phospholipase D and phosphatidic acid during phagocytosis.''; PubMed Europe PMC Scholia
  64. Mitchell MA, Huang MM, Chien P, Indik ZK, Pan XQ, Schreiber AD.; ''Substitutions and deletions in the cytoplasmic domain of the phagocytic receptor Fc gamma RIIA: effect on receptor tyrosine phosphorylation and phagocytosis.''; PubMed Europe PMC Scholia
  65. Le Clainche C, Pantaloni D, Carlier MF.; ''ATP hydrolysis on actin-related protein 2/3 complex causes debranching of dendritic actin arrays.''; PubMed Europe PMC Scholia
  66. Deckert M, Tartare-Deckert S, Couture C, Mustelin T, Altman A.; ''Functional and physical interactions of Syk family kinases with the Vav proto-oncogene product.''; PubMed Europe PMC Scholia
  67. Massol P, Montcourrier P, Guillemot JC, Chavrier P.; ''Fc receptor-mediated phagocytosis requires CDC42 and Rac1.''; PubMed Europe PMC Scholia
  68. Xu X, Chong AS.; ''Vav in natural killer cells is tyrosine phosphorylated upon cross-linking of Fc gamma RIIIA and is constitutively associated with a serine/threonine kinase.''; PubMed Europe PMC Scholia
  69. Scott CC, Dobson W, Botelho RJ, Coady-Osberg N, Chavrier P, Knecht DA, Heath C, Stahl P, Grinstein S.; ''Phosphatidylinositol-4,5-bisphosphate hydrolysis directs actin remodeling during phagocytosis.''; PubMed Europe PMC Scholia
  70. Park H, Cox D.; ''Cdc42 regulates Fc gamma receptor-mediated phagocytosis through the activation and phosphorylation of Wiskott-Aldrich syndrome protein (WASP) and neural-WASP.''; PubMed Europe PMC Scholia
  71. Mullins RD, Heuser JA, Pollard TD.; ''The interaction of Arp2/3 complex with actin: nucleation, high affinity pointed end capping, and formation of branching networks of filaments.''; PubMed Europe PMC Scholia
  72. Kiener PA, Rankin BM, Burkhardt AL, Schieven GL, Gilliland LK, Rowley RB, Bolen JB, Ledbetter JA.; ''Cross-linking of Fc gamma receptor I (Fc gamma RI) and receptor II (Fc gamma RII) on monocytic cells activates a signal transduction pathway common to both Fc receptors that involves the stimulation of p72 Syk protein tyrosine kinase.''; PubMed Europe PMC Scholia
  73. Chavrier P.; ''May the force be with you: Myosin-X in phagocytosis.''; PubMed Europe PMC Scholia
  74. Hall AB, Gakidis MA, Glogauer M, Wilsbacher JL, Gao S, Swat W, Brugge JS.; ''Requirements for Vav guanine nucleotide exchange factors and Rho GTPases in FcgammaR- and complement-mediated phagocytosis.''; PubMed Europe PMC Scholia
  75. Moon KD, Post CB, Durden DL, Zhou Q, De P, Harrison ML, Geahlen RL.; ''Molecular basis for a direct interaction between the Syk protein-tyrosine kinase and phosphoinositide 3-kinase.''; PubMed Europe PMC Scholia
  76. Wang QJ.; ''PKD at the crossroads of DAG and PKC signaling.''; PubMed Europe PMC Scholia
  77. Amann KJ, Pollard TD.; ''The Arp2/3 complex nucleates actin filament branches from the sides of pre-existing filaments.''; PubMed Europe PMC Scholia
  78. Nimmerjahn F, Ravetch JV.; ''Fcgamma receptors: old friends and new family members.''; PubMed Europe PMC Scholia
  79. Agarwal A, Salem P, Robbins KC.; ''Involvement of p72syk, a protein-tyrosine kinase, in Fc gamma receptor signaling.''; PubMed Europe PMC Scholia
  80. Kim YJ, Sekiya F, Poulin B, Bae YS, Rhee SG.; ''Mechanism of B-cell receptor-induced phosphorylation and activation of phospholipase C-gamma2.''; PubMed Europe PMC Scholia
  81. Millard TH, Sharp SJ, Machesky LM.; ''Signalling to actin assembly via the WASP (Wiskott-Aldrich syndrome protein)-family proteins and the Arp2/3 complex.''; PubMed Europe PMC Scholia
  82. Le Clainche C, Carlier MF.; ''Regulation of actin assembly associated with protrusion and adhesion in cell migration.''; PubMed Europe PMC Scholia
  83. Ernst LK, Duchemin AM, Anderson CL.; ''Association of the high-affinity receptor for IgG (Fc gamma RI) with the gamma subunit of the IgE receptor.''; PubMed Europe PMC Scholia
  84. Tsang E, Giannetti AM, Shaw D, Dinh M, Tse JK, Gandhi S, Ho H, Wang S, Papp E, Bradshaw JM.; ''Molecular mechanism of the Syk activation switch.''; PubMed Europe PMC Scholia
  85. Swanson JA, Johnson MT, Beningo K, Post P, Mooseker M, Araki N.; ''A contractile activity that closes phagosomes in macrophages.''; PubMed Europe PMC Scholia
  86. Takeuchi M, Harigai M, Momohara S, Ball E, Abe J, Furuichi K, Kamatani N.; ''Cloning and characterization of DPPL1 and DPPL2, representatives of a novel type of mammalian phosphatidate phosphatase.''; PubMed Europe PMC Scholia
  87. Sekiya F, Poulin B, Kim YJ, Rhee SG.; ''Mechanism of tyrosine phosphorylation and activation of phospholipase C-gamma 1. Tyrosine 783 phosphorylation is not sufficient for lipase activation.''; PubMed Europe PMC Scholia
  88. Zalevsky J, Lempert L, Kranitz H, Mullins RD.; ''Different WASP family proteins stimulate different Arp2/3 complex-dependent actin-nucleating activities.''; PubMed Europe PMC Scholia
  89. Brooks DG, Qiu WQ, Luster AD, Ravetch JV.; ''Structure and expression of human IgG FcRII(CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes.''; PubMed Europe PMC Scholia
  90. Strzelecka A, Kwiatkowska K, Sobota A.; ''Tyrosine phosphorylation and Fcgamma receptor-mediated phagocytosis.''; PubMed Europe PMC Scholia
  91. Ghazizadeh S, Bolen JB, Fleit HB.; ''Tyrosine phosphorylation and association of Syk with Fc gamma RII in monocytic THP-1 cells.''; PubMed Europe PMC Scholia
  92. Cory GO, Garg R, Cramer R, Ridley AJ.; ''Phosphorylation of tyrosine 291 enhances the ability of WASp to stimulate actin polymerization and filopodium formation. Wiskott-Aldrich Syndrome protein.''; PubMed Europe PMC Scholia
  93. van Vugt MJ, Heijnen IA, Capel PJ, Park SY, Ra C, Saito T, Verbeek JS, van de Winkel JG.; ''FcR gamma-chain is essential for both surface expression and function of human Fc gamma RI (CD64) in vivo.''; PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
118475view20:32, 27 May 2021FinterlyRemoved incorrect and duplicated openControlledVocabulary PW:0000234
114947view16:47, 25 January 2021ReactomeTeamReactome version 75
113391view11:46, 2 November 2020ReactomeTeamReactome version 74
112853view13:31, 12 October 2020DeSlFixing ontology tag error
112849view13:02, 12 October 2020DeSlOntology Term : 'innate immune response pathway' added !
112596view15:57, 9 October 2020ReactomeTeamReactome version 73
101512view11:37, 1 November 2018ReactomeTeamreactome version 66
101048view21:19, 31 October 2018ReactomeTeamreactome version 65
100579view19:52, 31 October 2018ReactomeTeamreactome version 64
100128view16:38, 31 October 2018ReactomeTeamreactome version 63
99678view15:07, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99271view12:45, 31 October 2018ReactomeTeamreactome version 62
94053view13:54, 16 August 2017ReactomeTeamreactome version 61
93681view11:30, 9 August 2017ReactomeTeamreactome version 61
89466view13:21, 15 September 2016Mkutmonfix ontology tag annotation
87448view13:50, 22 July 2016MkutmonOntology Term : 'PW:0000234' added !
86805view09:26, 11 July 2016ReactomeTeamreactome version 56
83122view10:02, 18 November 2015ReactomeTeamVersion54
81461view12:59, 21 August 2015ReactomeTeamVersion53
76936view08:20, 17 July 2014ReactomeTeamFixed remaining interactions
76641view12:01, 16 July 2014ReactomeTeamFixed remaining interactions
75971view10:02, 11 June 2014ReactomeTeamRe-fixing comment source
75674view10:59, 10 June 2014ReactomeTeamReactome 48 Update
75029view13:54, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74673view08:44, 30 April 2014ReactomeTeamNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
2-LysophosphatidylcholineMetaboliteCHEBI:17504 (ChEBI)
ABI1 ProteinQ8IZP0 (Uniprot-TrEMBL)
ABI2 ProteinQ9NYB9 (Uniprot-TrEMBL)
ABL1ProteinP00519 (Uniprot-TrEMBL)
ACTB(1-375) ProteinP60709 (Uniprot-TrEMBL)
ACTG1 ProteinP63261 (Uniprot-TrEMBL)
ACTR2 ProteinP61160 (Uniprot-TrEMBL)
ACTR3 ProteinP61158 (Uniprot-TrEMBL)
ADP MetaboliteCHEBI:16761 (ChEBI)
ADPMetaboliteCHEBI:16761 (ChEBI)
AHCYL1 ProteinO43865 (Uniprot-TrEMBL)
AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramerComplexR-HSA-5226920 (Reactome)
ARAMetaboliteCHEBI:15843 (ChEBI)
ARP2/3 complex (ATP bound)ComplexR-HSA-1861670 (Reactome)
ARPC1A ProteinQ92747 (Uniprot-TrEMBL)
ARPC1B ProteinO15143 (Uniprot-TrEMBL)
ARPC2 ProteinO15144 (Uniprot-TrEMBL)
ARPC3 ProteinO15145 (Uniprot-TrEMBL)
ARPC4 ProteinP59998 (Uniprot-TrEMBL)
ARPC5 ProteinO15511 (Uniprot-TrEMBL)
ATP MetaboliteCHEBI:15422 (ChEBI)
ATPMetaboliteCHEBI:15422 (ChEBI)
Actin filament bound Myosin-XComplexR-HSA-1861625 (Reactome)
Actin:ADPComplexR-HSA-202994 (Reactome)
Activated WAVE2 and

WASP/N-WASP:ARP2/3

complex:G-actin		ComplexR-HSA-442565 (Reactome)
Activated WAVE2 and WASP/N-WASPComplexR-HSA-2197675 (Reactome)
Active LIMK1ComplexR-HSA-419630 (Reactome)
Antigen R-NUL-173548 (Reactome)
Antigen-antibody complexComplexR-HSA-173552 (Reactome)
BAIAP2 ProteinQ9UQB8 (Uniprot-TrEMBL)
BAIAP2ProteinQ9UQB8 (Uniprot-TrEMBL)
BRK1 ProteinQ8WUW1 (Uniprot-TrEMBL)
BTK ProteinQ06187 (Uniprot-TrEMBL)
CD247-1 ProteinP20963-1 (Uniprot-TrEMBL)
CD3G ProteinP09693 (Uniprot-TrEMBL)
CDC42 ProteinP60953 (Uniprot-TrEMBL)
CDC42:GDPComplexR-HSA-418830 (Reactome)
CDC42:GTP, RAC1:GTPComplexR-HSA-389778 (Reactome)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteinsComplexR-HSA-2197683 (Reactome)
CDC42:GTP:WASP/N-WASPComplexR-HSA-442584 (Reactome)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteinsComplexR-HSA-2197680 (Reactome)
CDC42:GTPComplexR-HSA-182921 (Reactome)
CFL1ProteinP23528 (Uniprot-TrEMBL)
CRK ProteinP46108 (Uniprot-TrEMBL)
CRK:DOCK180:ELMO1,ELMO2ComplexR-HSA-2029141 (Reactome)
CRKII:DOCK180:ELMO

complex recruited

to phagocytic cup		ComplexR-HSA-2029130 (Reactome)
CYFIP1 ProteinQ7L576 (Uniprot-TrEMBL)
CYFIP2 ProteinQ96F07 (Uniprot-TrEMBL)
Ca2+MetaboliteCHEBI:29108 (ChEBI)
ChoMetaboliteCHEBI:15354 (ChEBI)
DAGsMetaboliteCHEBI:18035 (ChEBI)
DOCK1 ProteinQ14185 (Uniprot-TrEMBL)
ELMO1 ProteinQ92556 (Uniprot-TrEMBL)
ELMO2 ProteinQ96JJ3 (Uniprot-TrEMBL)
F-actin R-HSA-201877 (Reactome)
F-actinR-HSA-201877 (Reactome)
FAK1 ProteinQ05397 (Uniprot-TrEMBL)
FCGR1A ProteinP12314 (Uniprot-TrEMBL)
FCGR2A ProteinP12318 (Uniprot-TrEMBL)
FCGR2AProteinP12318 (Uniprot-TrEMBL)
FCGR3A ProteinP08637 (Uniprot-TrEMBL)
FCGRIA:CD3G homodimerComplexR-HSA-2029093 (Reactome)
FCGRIIIA:CD3G/CD3Z dimersComplexR-HSA-2029097 (Reactome)
FGR ProteinP09769 (Uniprot-TrEMBL)
FYN ProteinP06241 (Uniprot-TrEMBL)
G-actinComplexR-HSA-201857 (Reactome)
GDP MetaboliteCHEBI:17552 (ChEBI)
GDPMetaboliteCHEBI:17552 (ChEBI)
GRB2-1 ProteinP62993-1 (Uniprot-TrEMBL)
GTP MetaboliteCHEBI:15996 (ChEBI)
GTPMetaboliteCHEBI:15996 (ChEBI)
H2OMetaboliteCHEBI:15377 (ChEBI)
HCK ProteinP08631 (Uniprot-TrEMBL)
HSP90AA1 ProteinP07900 (Uniprot-TrEMBL)
HSP90AA1,HSP90AB1ComplexR-HSA-419619 (Reactome)
HSP90AB1 ProteinP08238 (Uniprot-TrEMBL)
I(1,4,5)P3 MetaboliteCHEBI:16595 (ChEBI)
I(1,4,5)P3MetaboliteCHEBI:16595 (ChEBI)
IGHG1 ProteinP01857 (Uniprot-TrEMBL)
IGHG2 ProteinP01859 (Uniprot-TrEMBL)
IGHG3 ProteinP01860 (Uniprot-TrEMBL)
IGHG4 ProteinP01861 (Uniprot-TrEMBL)
IGHV(1-?) ProteinA2KUC3 (Uniprot-TrEMBL)
IGHV7-81(1-?) ProteinQ6PIL0 (Uniprot-TrEMBL)
IGKC ProteinP01834 (Uniprot-TrEMBL)
IGKV1-5(23-?) ProteinP01602 (Uniprot-TrEMBL)
IGKV4-1(21-?) ProteinP06312 (Uniprot-TrEMBL)
IGKVA18(21-?) ProteinA2NJV5 (Uniprot-TrEMBL)
IGLC1 ProteinP0CG04 (Uniprot-TrEMBL)
IGLC2 ProteinP0CG05 (Uniprot-TrEMBL)
IGLC3 ProteinP0CG06 (Uniprot-TrEMBL)
IGLC6 ProteinP0CF74 (Uniprot-TrEMBL)
IGLC7 ProteinA0M8Q6 (Uniprot-TrEMBL)
IGLV(23-?) ProteinA2NXD2 (Uniprot-TrEMBL)
IGLV1-36(1-?) ProteinQ5NV67 (Uniprot-TrEMBL)
IGLV1-40(1-?) ProteinQ5NV69 (Uniprot-TrEMBL)
IGLV1-44(1-?) ProteinQ5NV81 (Uniprot-TrEMBL)
IGLV10-54(1-?) ProteinQ5NV86 (Uniprot-TrEMBL)
IGLV11-55(1-?) ProteinQ5NV87 (Uniprot-TrEMBL)
IGLV2-11(1-?) ProteinQ5NV84 (Uniprot-TrEMBL)
IGLV2-18(1-?) ProteinQ5NV65 (Uniprot-TrEMBL)
IGLV2-23(1-?) ProteinQ5NV89 (Uniprot-TrEMBL)
IGLV2-33(1-?) ProteinQ5NV66 (Uniprot-TrEMBL)
IGLV3-12(1-?) ProteinQ5NV85 (Uniprot-TrEMBL)
IGLV3-16(1-?) ProteinQ5NV64 (Uniprot-TrEMBL)
IGLV3-22(1-?) ProteinQ5NV75 (Uniprot-TrEMBL)
IGLV3-25(1-?) ProteinQ5NV90 (Uniprot-TrEMBL)
IGLV3-27(1-?) ProteinQ5NV91 (Uniprot-TrEMBL)
IGLV4-3(1-?) ProteinQ5NV61 (Uniprot-TrEMBL)
IGLV4-60(1-?) ProteinQ5NV79 (Uniprot-TrEMBL)
IGLV4-69(1-?) ProteinQ5NV92 (Uniprot-TrEMBL)
IGLV5-37(1-?) ProteinQ5NV68 (Uniprot-TrEMBL)
IGLV5-45(1-?) ProteinQ5NV82 (Uniprot-TrEMBL)
IGLV7-43(1-?) ProteinQ5NV80 (Uniprot-TrEMBL)
IGLV7-46(1-?) ProteinQ5NV83 (Uniprot-TrEMBL)
IGLV8-61(1-?) ProteinQ5NV62 (Uniprot-TrEMBL)
IP3 receptor homotetramerComplexR-HSA-169686 (Reactome)
ITPR1 ProteinQ14643 (Uniprot-TrEMBL)
ITPR2 ProteinQ14571 (Uniprot-TrEMBL)
ITPR3 ProteinQ14573 (Uniprot-TrEMBL)
ITPR:I(1,4,5)P3 tetramerComplexR-HSA-169696 (Reactome)
Ig heavy chain V-I region EU ProteinP01742 (Uniprot-TrEMBL)
Ig heavy chain V-I region HG3 ProteinP01743 (Uniprot-TrEMBL)
Ig heavy chain V-I region Mot ProteinP06326 (Uniprot-TrEMBL)
Ig heavy chain V-I region ND ProteinP01744 (Uniprot-TrEMBL)
Ig heavy chain V-I region SIE ProteinP01761 (Uniprot-TrEMBL)
Ig heavy chain V-I region WOL ProteinP01760 (Uniprot-TrEMBL)
Ig heavy chain V-II region ARH-77 ProteinP06331 (Uniprot-TrEMBL)
Ig heavy chain V-II region COR ProteinP01815 (Uniprot-TrEMBL)
Ig heavy chain V-II region DAW ProteinP01816 (Uniprot-TrEMBL)
Ig heavy chain V-II region HE ProteinP01818 (Uniprot-TrEMBL)
Ig heavy chain V-II region MCE ProteinP01817 (Uniprot-TrEMBL)
Ig heavy chain V-II region NEWM ProteinP01825 (Uniprot-TrEMBL)
Ig heavy chain V-II region OU ProteinP01814 (Uniprot-TrEMBL)
Ig heavy chain V-II region SESS ProteinP04438 (Uniprot-TrEMBL)
Ig heavy chain V-II region WAH ProteinP01824 (Uniprot-TrEMBL)
Ig heavy chain V-III region BRO ProteinP01766 (Uniprot-TrEMBL)
Ig heavy chain V-III region BUR ProteinP01773 (Uniprot-TrEMBL)
Ig heavy chain V-III region BUT ProteinP01767 (Uniprot-TrEMBL)
Ig heavy chain V-III region CAM ProteinP01768 (Uniprot-TrEMBL)
Ig heavy chain V-III region DOB ProteinP01782 (Uniprot-TrEMBL)
Ig heavy chain V-III region GA ProteinP01769 (Uniprot-TrEMBL)
Ig heavy chain V-III region GAL ProteinP01781 (Uniprot-TrEMBL)
Ig heavy chain V-III region HIL ProteinP01771 (Uniprot-TrEMBL)
Ig heavy chain V-III region JON ProteinP01780 (Uniprot-TrEMBL)
Ig heavy chain V-III region KOL ProteinP01772 (Uniprot-TrEMBL)
Ig heavy chain V-III region LAY ProteinP01775 (Uniprot-TrEMBL)
Ig heavy chain V-III region NIE ProteinP01770 (Uniprot-TrEMBL)
Ig heavy chain V-III region POM ProteinP01774 (Uniprot-TrEMBL)
Ig heavy chain V-III region TEI ProteinP01777 (Uniprot-TrEMBL)
Ig heavy chain V-III region TIL ProteinP01765 (Uniprot-TrEMBL)
Ig heavy chain V-III region TRO ProteinP01762 (Uniprot-TrEMBL)
Ig heavy chain V-III region TUR ProteinP01779 (Uniprot-TrEMBL)
Ig heavy chain V-III region WAS ProteinP01776 (Uniprot-TrEMBL)
Ig heavy chain V-III region WEA ProteinP01763 (Uniprot-TrEMBL)
Ig heavy chain V-III region ZAP ProteinP01778 (Uniprot-TrEMBL)
Ig kappa chain V region EV15 ProteinP06315 (Uniprot-TrEMBL)
Ig kappa chain V-I region AG ProteinP01593 (Uniprot-TrEMBL)
Ig kappa chain V-I region AU ProteinP01594 (Uniprot-TrEMBL)
Ig kappa chain V-I region BAN ProteinP04430 (Uniprot-TrEMBL)
Ig kappa chain V-I region Bi ProteinP01595 (Uniprot-TrEMBL)
Ig kappa chain V-I region CAR ProteinP01596 (Uniprot-TrEMBL)
Ig kappa chain V-I region DEE ProteinP01597 (Uniprot-TrEMBL)
Ig kappa chain V-I region Daudi ProteinP04432 (Uniprot-TrEMBL)
Ig kappa chain V-I region EU ProteinP01598 (Uniprot-TrEMBL)
Ig kappa chain V-I region Gal ProteinP01599 (Uniprot-TrEMBL)
Ig kappa chain V-I region HK101 ProteinP01601 (Uniprot-TrEMBL)
Ig kappa chain V-I region Hau ProteinP01600 (Uniprot-TrEMBL)
Ig kappa chain V-I region Ka ProteinP01603 (Uniprot-TrEMBL)
Ig kappa chain V-I region Kue ProteinP01604 (Uniprot-TrEMBL)
Ig kappa chain V-I region Lay ProteinP01605 (Uniprot-TrEMBL)
Ig kappa chain V-I region Mev ProteinP01612 (Uniprot-TrEMBL)
Ig kappa chain V-I region Ni ProteinP01613 (Uniprot-TrEMBL)
Ig kappa chain V-I region OU ProteinP01606 (Uniprot-TrEMBL)
Ig kappa chain V-I region Rei ProteinP01607 (Uniprot-TrEMBL)
Ig kappa chain V-I region Roy ProteinP01608 (Uniprot-TrEMBL)
Ig kappa chain V-I region Scw ProteinP01609 (Uniprot-TrEMBL)
Ig kappa chain V-I region WAT ProteinP80362 (Uniprot-TrEMBL)
Ig kappa chain V-I region WEA ProteinP01610 (Uniprot-TrEMBL)
Ig kappa chain V-I region Walker ProteinP04431 (Uniprot-TrEMBL)
Ig kappa chain V-I region Wes ProteinP01611 (Uniprot-TrEMBL)
Ig kappa chain V-II region Cum ProteinP01614 (Uniprot-TrEMBL)
Ig kappa chain V-II region FR ProteinP01615 (Uniprot-TrEMBL)
Ig kappa chain V-II region GM607 ProteinP06309 (Uniprot-TrEMBL)
Ig kappa chain V-II region MIL ProteinP01616 (Uniprot-TrEMBL)
Ig kappa chain V-II region RPMI 6410 ProteinP06310 (Uniprot-TrEMBL)
Ig kappa chain V-II region TEW ProteinP01617 (Uniprot-TrEMBL)
Ig kappa chain V-III region B6 ProteinP01619 (Uniprot-TrEMBL)
Ig kappa chain V-III region CLL ProteinP04207 (Uniprot-TrEMBL)
Ig kappa chain V-III region GOL ProteinP04206 (Uniprot-TrEMBL)
Ig kappa chain V-III region HAH ProteinP18135 (Uniprot-TrEMBL)
Ig kappa chain V-III region HIC ProteinP18136 (Uniprot-TrEMBL)
Ig kappa chain V-III region IARC/BL41 ProteinP06311 (Uniprot-TrEMBL)
Ig kappa chain V-III region NG9 ProteinP01621 (Uniprot-TrEMBL)
Ig kappa chain V-III region POM ProteinP01624 (Uniprot-TrEMBL)
Ig kappa chain V-III region SIE ProteinP01620 (Uniprot-TrEMBL)
Ig kappa chain V-III region Ti ProteinP01622 (Uniprot-TrEMBL)
Ig kappa chain V-III region VG ProteinP04433 (Uniprot-TrEMBL)
Ig kappa chain V-III region VH ProteinP04434 (Uniprot-TrEMBL)
Ig kappa chain V-III region WOL ProteinP01623 (Uniprot-TrEMBL)
Ig kappa chain V-IV region B17 ProteinP06314 (Uniprot-TrEMBL)
Ig kappa chain V-IV region JI ProteinP06313 (Uniprot-TrEMBL)
Ig kappa chain V-IV region Len ProteinP01625 (Uniprot-TrEMBL)
Ig kappa chain V-IV region STH ProteinP83593 (Uniprot-TrEMBL)
Ig lambda chain V region 4A ProteinP04211 (Uniprot-TrEMBL)
Ig lambda chain V-I region BL2 ProteinP06316 (Uniprot-TrEMBL)
Ig lambda chain V-I region EPS ProteinP06888 (Uniprot-TrEMBL)
Ig lambda chain V-I region HA ProteinP01700 (Uniprot-TrEMBL)
Ig lambda chain V-I region MEM ProteinP06887 (Uniprot-TrEMBL)
Ig lambda chain V-I region NEW ProteinP01701 (Uniprot-TrEMBL)
Ig lambda chain V-I region NEWM ProteinP01703 (Uniprot-TrEMBL)
Ig lambda chain V-I region NIG-64 ProteinP01702 (Uniprot-TrEMBL)
Ig lambda chain V-I region VOR ProteinP01699 (Uniprot-TrEMBL)
Ig lambda chain V-I region WAH ProteinP04208 (Uniprot-TrEMBL)
Ig lambda chain V-II region BO ProteinP01710 (Uniprot-TrEMBL)
Ig lambda chain V-II region BOH ProteinP01706 (Uniprot-TrEMBL)
Ig lambda chain V-II region BUR ProteinP01708 (Uniprot-TrEMBL)
Ig lambda chain V-II region MGC ProteinP01709 (Uniprot-TrEMBL)
Ig lambda chain V-II region NEI ProteinP01705 (Uniprot-TrEMBL)
Ig lambda chain V-II region NIG-58 ProteinP01713 (Uniprot-TrEMBL)
Ig lambda chain V-II region NIG-84 ProteinP04209 (Uniprot-TrEMBL)
Ig lambda chain V-II region TOG ProteinP01704 (Uniprot-TrEMBL)
Ig lambda chain V-II region TRO ProteinP01707 (Uniprot-TrEMBL)
Ig lambda chain V-II region VIL ProteinP01711 (Uniprot-TrEMBL)
Ig lambda chain V-II region WIN ProteinP01712 (Uniprot-TrEMBL)
Ig lambda chain V-III region LOI ProteinP80748 (Uniprot-TrEMBL)
Ig lambda chain V-III region SH ProteinP01714 (Uniprot-TrEMBL)
Ig lambda chain V-IV region Bau ProteinP01715 (Uniprot-TrEMBL)
Ig lambda chain V-IV region Hil ProteinP01717 (Uniprot-TrEMBL)
Ig lambda chain V-IV region Kern ProteinP01718 (Uniprot-TrEMBL)
Ig lambda chain V-IV region MOL ProteinP06889 (Uniprot-TrEMBL)
Ig lambda chain V-IV region X ProteinP01716 (Uniprot-TrEMBL)
Ig lambda chain V-V region DEL ProteinP01719 (Uniprot-TrEMBL)
Ig lambda chain V-VI region AR ProteinP01721 (Uniprot-TrEMBL)
Ig lambda chain V-VI region EB4 ProteinP06319 (Uniprot-TrEMBL)
Ig lambda chain V-VI region NIG-48 ProteinP01722 (Uniprot-TrEMBL)
Ig lambda chain V-VI region SUT ProteinP06317 (Uniprot-TrEMBL)
Ig lambda chain V-VI region WLT ProteinP06318 (Uniprot-TrEMBL)
Ig lambda chain V-VII region MOT ProteinP01720 (Uniprot-TrEMBL)
IgG-Ag:FCGRIA:CD3G homodimerComplexR-HSA-2029132 (Reactome)
IgG-Ag:FCGRIIAComplexR-HSA-1861689 (Reactome)
IgG-Ag:FCGRIIIA:CD3G/CD3Z dimersComplexR-HSA-2029163 (Reactome)
IgH heavy chain V-III region VH26 precursor ProteinP01764 (Uniprot-TrEMBL)
LIMK1ProteinP53667 (Uniprot-TrEMBL)
LYN ProteinP07948 (Uniprot-TrEMBL)
MYH2 ProteinQ9UKX2 (Uniprot-TrEMBL)
MYH9 ProteinP35579 (Uniprot-TrEMBL)
MYO10 ProteinQ9HD67 (Uniprot-TrEMBL)
MYO1C ProteinO00159 (Uniprot-TrEMBL)
MYO5A ProteinQ9Y4I1 (Uniprot-TrEMBL)
MYO9B ProteinQ13459 (Uniprot-TrEMBL)
Mother filament:ARP2/3:actin:GDPComplexR-HSA-2197686 (Reactome)
Mother

filament:branching complex:daughter

filament		ComplexR-HSA-1861699 (Reactome)
Mother

filament:branching

complex		ComplexR-HSA-2029140 (Reactome)
Myosin-Actin filamentsComplexR-HSA-2029139 (Reactome)
Myosin-X dimerComplexR-HSA-1861665 (Reactome)
MyosinComplexR-HSA-2029109 (Reactome)
N-WASP ProteinO00401 (Uniprot-TrEMBL)
NAD+ MetaboliteCHEBI:15846 (ChEBI)
NCK1 ProteinP16333 (Uniprot-TrEMBL)
NCKAP1 ProteinQ9Y2A7 (Uniprot-TrEMBL)
NCKAP1L ProteinP55160 (Uniprot-TrEMBL)
NCKIPSD ProteinQ9NZQ3 (Uniprot-TrEMBL)
PAMetaboliteCHEBI:16337 (ChEBI)
PAK1 ProteinQ13153 (Uniprot-TrEMBL)
PAK1 dimerComplexR-HSA-445002 (Reactome)
PAK1ProteinQ13153 (Uniprot-TrEMBL)
PCMetaboliteCHEBI:16110 (ChEBI)
PI(3,4)P2 MetaboliteCHEBI:16152 (ChEBI)
PI(3,4)P2MetaboliteCHEBI:16152 (ChEBI)
PI(3,4,5)P3 MetaboliteCHEBI:16618 (ChEBI)
PI(3,4,5)P3MetaboliteCHEBI:16618 (ChEBI)
PI(4,5)P2 MetaboliteCHEBI:18348 (ChEBI)
PI(4,5)P2MetaboliteCHEBI:18348 (ChEBI)
PI3K:p-6Y-SYKComplexR-HSA-2029149 (Reactome)
PI3KComplexR-HSA-74693 (Reactome)
PIK3CA ProteinP42336 (Uniprot-TrEMBL)
PIK3CB ProteinP42338 (Uniprot-TrEMBL)
PIK3R1 ProteinP27986 (Uniprot-TrEMBL)
PIK3R2 ProteinO00459 (Uniprot-TrEMBL)
PKC-delta/epsilonComplexR-HSA-198276 (Reactome)
PLA2G6ProteinO60733 (Uniprot-TrEMBL)
PLC gamma1,2ComplexR-HSA-1169089 (Reactome)
PLCG1 ProteinP19174 (Uniprot-TrEMBL)
PLCG2 ProteinP16885 (Uniprot-TrEMBL)
PLD1 ProteinQ13393 (Uniprot-TrEMBL)
PLD2 ProteinO14939 (Uniprot-TrEMBL)
PLD3 ProteinQ8IV08 (Uniprot-TrEMBL)
PLD4 ProteinQ96BZ4 (Uniprot-TrEMBL)
PLDComplexR-HSA-2029102 (Reactome)
PPAPDC1A ProteinQ5VZY2 (Uniprot-TrEMBL)
PPAPDC1B ProteinQ8NEB5 (Uniprot-TrEMBL)
PRKCD ProteinQ05655 (Uniprot-TrEMBL)
PRKCE ProteinQ02156 (Uniprot-TrEMBL)
Phosphatidate phosphataseComplexR-HSA-2029101 (Reactome)
Phospho-PKC-delta/epsilonComplexR-HSA-198265 (Reactome)
PiMetaboliteCHEBI:18367 (ChEBI)
RAC1 ProteinP63000 (Uniprot-TrEMBL)
RAC1/CDC42:PAK dimerComplexR-HSA-2029159 (Reactome)
RAC1/CDC42:p-S144,T423-PAKComplexR-HSA-2029155 (Reactome)
RAC1:GDPComplexR-HSA-5674631 (Reactome)
RAC1:GTPComplexR-HSA-442641 (Reactome)
SH3 domain proteinsComplexR-HSA-2197679 (Reactome)
SRC-1 ProteinP12931-1 (Uniprot-TrEMBL)
SYK ProteinP43405 (Uniprot-TrEMBL)
SYKProteinP43405 (Uniprot-TrEMBL)
Src family kinases (SFKs)ComplexR-HSA-1861597 (Reactome)
Src-kinasesComplexR-HSA-2197681 (Reactome)
VAV1 ProteinP15498 (Uniprot-TrEMBL)
VAV1,2,3ComplexR-HSA-430172 (Reactome)
VAV2 ProteinP52735 (Uniprot-TrEMBL)
VAV3 ProteinQ9UKW4 (Uniprot-TrEMBL)
WAS ProteinP42768 (Uniprot-TrEMBL)
WASF1 ProteinQ92558 (Uniprot-TrEMBL)
WASF2 ProteinQ9Y6W5 (Uniprot-TrEMBL)
WASF3 ProteinQ9UPY6 (Uniprot-TrEMBL)
WASP/N-WASPComplexR-HSA-201892 (Reactome)
WAVE Regulatory ComplexComplexR-HSA-2029154 (Reactome)
WIP family proteinsComplexR-HSA-2197678 (Reactome)
WIPF1 ProteinO43516 (Uniprot-TrEMBL)
WIPF2 ProteinQ8TF74 (Uniprot-TrEMBL)
WIPF3 ProteinA6NGB9 (Uniprot-TrEMBL)
WRC:IRSp53/58:RAC1:GTP:PIP3ComplexR-HSA-2029147 (Reactome)
YES1 ProteinP07947 (Uniprot-TrEMBL)
clustered IgG-Ag:FCGRsComplexR-HSA-2029146 (Reactome)
clustered IgG-Ag:p-FCGRs:SYKComplexR-HSA-2029129 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCGComplexR-HSA-2029137 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAVComplexR-HSA-2029133 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCGComplexR-HSA-2029156 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-VAVComplexR-HSA-2029131 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYKComplexR-HSA-2029158 (Reactome)
clustered IgG-Ag:p-FCGRsComplexR-HSA-2029128 (Reactome)
clustered IgG-Ag:p-FCGRsComplexR-HSA-2029151 (Reactome)
p-4S-ABI2 ProteinQ9NYB9 (Uniprot-TrEMBL)
p-4Y-PLCG1 ProteinP19174 (Uniprot-TrEMBL)
p-4Y-PLCG1ProteinP19174 (Uniprot-TrEMBL)
p-5S-ABI1 ProteinQ8IZP0 (Uniprot-TrEMBL)
p-6Y-CD247-1 ProteinP20963-1 (Uniprot-TrEMBL)
p-6Y-SYK ProteinP43405 (Uniprot-TrEMBL)
p-PLCGComplexR-HSA-2029095 (Reactome)
p-S,T508-LIMK1 ProteinP53667 (Uniprot-TrEMBL)
p-S144,T423-PAK1 ProteinQ13153 (Uniprot-TrEMBL)
p-S144,T423-PAK1ProteinQ13153 (Uniprot-TrEMBL)
p-S3-CFL1 ProteinP23528 (Uniprot-TrEMBL)
p-T,Y MAPK dimersComplexR-HSA-1268261 (Reactome)
p-T185,Y187-MAPK1 ProteinP28482 (Uniprot-TrEMBL)
p-T202,Y204-MAPK3 ProteinP27361 (Uniprot-TrEMBL)
p-T507,S645,S664-PRKCD(1-676) ProteinQ05655 (Uniprot-TrEMBL)
p-T508-LIMK1 ProteinP53667 (Uniprot-TrEMBL)
p-T508-LIMK1ProteinP53667 (Uniprot-TrEMBL)
p-T566,T710,S729-PRKCE ProteinQ02156 (Uniprot-TrEMBL)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3ComplexR-HSA-2029148 (Reactome)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3ComplexR-HSA-2130182 (Reactome)
p-Y150,S343,T346-WASF2 ProteinQ9Y6W5 (Uniprot-TrEMBL)
p-Y150-WASF2 ProteinQ9Y6W5 (Uniprot-TrEMBL)
p-Y151,S,T-WASF1 ProteinQ92558 (Uniprot-TrEMBL)
p-Y151,S,T-WASF3 ProteinQ9UPY6 (Uniprot-TrEMBL)
p-Y151-WASF1 ProteinQ92558 (Uniprot-TrEMBL)
p-Y151-WASF3 ProteinQ9UPY6 (Uniprot-TrEMBL)
p-Y160,Y171-CD3G ProteinP09693 (Uniprot-TrEMBL)
p-Y172-VAV2 ProteinP52735 (Uniprot-TrEMBL)
p-Y173-VAV3 ProteinQ9UKW4 (Uniprot-TrEMBL)
p-Y174-VAV1 ProteinP15498 (Uniprot-TrEMBL)
p-Y256-WASL ProteinO00401 (Uniprot-TrEMBL)
p-Y288,Y304-FCGR2A ProteinP12318 (Uniprot-TrEMBL)
p-Y291-WAS ProteinP42768 (Uniprot-TrEMBL)
p-Y753,Y759,Y1217-PLCG2 ProteinP16885 (Uniprot-TrEMBL)
pCofilin: Active LIMK-1ComplexR-HSA-399878 (Reactome)
pLIMK dimer:HSP-90ComplexR-HSA-419632 (Reactome)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
2-LysophosphatidylcholineArrowR-HSA-2029475 (Reactome)
ABL1mim-catalysisR-HSA-2130194 (Reactome)
ADPArrowR-HSA-198314 (Reactome)
ADPArrowR-HSA-2029268 (Reactome)
ADPArrowR-HSA-2029271 (Reactome)
ADPArrowR-HSA-2029449 (Reactome)
ADPArrowR-HSA-2029453 (Reactome)
ADPArrowR-HSA-2029454 (Reactome)
ADPArrowR-HSA-2029459 (Reactome)
ADPArrowR-HSA-2029460 (Reactome)
ADPArrowR-HSA-2029469 (Reactome)
ADPArrowR-HSA-2130194 (Reactome)
ADPArrowR-HSA-2197698 (Reactome)
ADPArrowR-HSA-399950 (Reactome)
ADPArrowR-HSA-419644 (Reactome)
AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramerTBarR-HSA-169683 (Reactome)
ARAArrowR-HSA-2029475 (Reactome)
ARP2/3 complex (ATP bound)R-HSA-442592 (Reactome)
ATPR-HSA-1861595 (Reactome)
ATPR-HSA-198314 (Reactome)
ATPR-HSA-2029268 (Reactome)
ATPR-HSA-2029271 (Reactome)
ATPR-HSA-2029449 (Reactome)
ATPR-HSA-2029453 (Reactome)
ATPR-HSA-2029454 (Reactome)
ATPR-HSA-2029459 (Reactome)
ATPR-HSA-2029460 (Reactome)
ATPR-HSA-2029469 (Reactome)
ATPR-HSA-2029476 (Reactome)
ATPR-HSA-2130194 (Reactome)
ATPR-HSA-2197698 (Reactome)
ATPR-HSA-399950 (Reactome)
ATPR-HSA-419644 (Reactome)
Actin filament bound Myosin-XArrowR-HSA-1861595 (Reactome)
Actin:ADPArrowR-HSA-2029473 (Reactome)
Activated WAVE2 and

WASP/N-WASP:ARP2/3

complex:G-actin		ArrowR-HSA-442592 (Reactome)
Activated WAVE2 and

WASP/N-WASP:ARP2/3

complex:G-actin		R-HSA-2029466 (Reactome)
Activated WAVE2 and WASP/N-WASPArrowR-HSA-2197690 (Reactome)
Activated WAVE2 and WASP/N-WASPR-HSA-442592 (Reactome)
Active LIMK1ArrowR-HSA-419644 (Reactome)
Active LIMK1R-HSA-399950 (Reactome)
Active LIMK1mim-catalysisR-HSA-399950 (Reactome)
Antigen-antibody complexR-HSA-1861621 (Reactome)
Antigen-antibody complexR-HSA-2029455 (Reactome)
Antigen-antibody complexR-HSA-2029457 (Reactome)
BAIAP2R-HSA-2029465 (Reactome)
CDC42:GDPR-HSA-2029445 (Reactome)
CDC42:GTP, RAC1:GTPR-HSA-2029456 (Reactome)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteinsArrowR-HSA-2197691 (Reactome)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteinsR-HSA-2197698 (Reactome)
CDC42:GTP:WASP/N-WASPArrowR-HSA-442586 (Reactome)
CDC42:GTP:WASP/N-WASPR-HSA-2197691 (Reactome)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteinsArrowR-HSA-2197698 (Reactome)
CDC42:GTPArrowR-HSA-2029445 (Reactome)
CDC42:GTPR-HSA-442586 (Reactome)
CFL1R-HSA-399950 (Reactome)
CRK:DOCK180:ELMO1,ELMO2R-HSA-2197697 (Reactome)
CRKII:DOCK180:ELMO

complex recruited

to phagocytic cup		ArrowR-HSA-2197697 (Reactome)
CRKII:DOCK180:ELMO

complex recruited

to phagocytic cup		mim-catalysisR-HSA-2029467 (Reactome)
Ca2+ArrowR-HSA-169683 (Reactome)
Ca2+R-HSA-169683 (Reactome)
ChoArrowR-HSA-2029471 (Reactome)
DAGsArrowR-HSA-167686 (Reactome)
DAGsArrowR-HSA-198314 (Reactome)
DAGsArrowR-HSA-2029468 (Reactome)
F-actinR-HSA-2029466 (Reactome)
FCGR2AR-HSA-1861621 (Reactome)
FCGRIA:CD3G homodimerR-HSA-2029455 (Reactome)
FCGRIIIA:CD3G/CD3Z dimersR-HSA-2029457 (Reactome)
G-actinR-HSA-2029473 (Reactome)
G-actinR-HSA-442592 (Reactome)
GDPArrowR-HSA-2029445 (Reactome)
GDPArrowR-HSA-2029451 (Reactome)
GDPArrowR-HSA-2029467 (Reactome)
GTPR-HSA-2029445 (Reactome)
GTPR-HSA-2029451 (Reactome)
GTPR-HSA-2029467 (Reactome)
H2OR-HSA-167686 (Reactome)
H2OR-HSA-2029468 (Reactome)
H2OR-HSA-2029471 (Reactome)
H2OR-HSA-2029475 (Reactome)
HSP90AA1,HSP90AB1ArrowR-HSA-419644 (Reactome)
HSP90AA1,HSP90AB1R-HSA-419645 (Reactome)
I(1,4,5)P3ArrowR-HSA-167686 (Reactome)
I(1,4,5)P3ArrowR-HSA-169683 (Reactome)
I(1,4,5)P3R-HSA-169680 (Reactome)
IP3 receptor homotetramerR-HSA-169680 (Reactome)
ITPR:I(1,4,5)P3 tetramerArrowR-HSA-169680 (Reactome)
ITPR:I(1,4,5)P3 tetramermim-catalysisR-HSA-169683 (Reactome)
IgG-Ag:FCGRIA:CD3G homodimerArrowR-HSA-2029455 (Reactome)
IgG-Ag:FCGRIIAArrowR-HSA-1861621 (Reactome)
IgG-Ag:FCGRIIIA:CD3G/CD3Z dimersArrowR-HSA-2029457 (Reactome)
LIMK1R-HSA-2029460 (Reactome)
Mother filament:ARP2/3:actin:GDPArrowR-HSA-2197690 (Reactome)
Mother filament:ARP2/3:actin:GDPR-HSA-2029473 (Reactome)
Mother

filament:branching complex:daughter

filament		ArrowR-HSA-2029473 (Reactome)
Mother

filament:branching complex:daughter

filament		R-HSA-1861595 (Reactome)
Mother

filament:branching complex:daughter

filament		R-HSA-2029476 (Reactome)
Mother

filament:branching

complex		ArrowR-HSA-2029466 (Reactome)
Mother

filament:branching

complex		R-HSA-2197690 (Reactome)
Myosin-Actin filamentsArrowR-HSA-2029476 (Reactome)
Myosin-X dimerR-HSA-1861595 (Reactome)
Myosin-X dimermim-catalysisR-HSA-1861595 (Reactome)
MyosinR-HSA-2029476 (Reactome)
PAArrowR-HSA-2029471 (Reactome)
PAK1 dimerR-HSA-2029456 (Reactome)
PAK1mim-catalysisR-HSA-2029454 (Reactome)
PAR-HSA-2029468 (Reactome)
PCR-HSA-2029471 (Reactome)
PCR-HSA-2029475 (Reactome)
PI(3,4)P2R-HSA-1861595 (Reactome)
PI(3,4,5)P3ArrowR-HSA-2029271 (Reactome)
PI(3,4,5)P3ArrowR-HSA-2029272 (Reactome)
PI(3,4,5)P3R-HSA-2029268 (Reactome)
PI(3,4,5)P3R-HSA-2029458 (Reactome)
PI(3,4,5)P3R-HSA-2029465 (Reactome)
PI(4,5)P2R-HSA-167686 (Reactome)
PI(4,5)P2R-HSA-2029271 (Reactome)
PI(4,5)P2R-HSA-442586 (Reactome)
PI3K:p-6Y-SYKArrowR-HSA-2029273 (Reactome)
PI3K:p-6Y-SYKmim-catalysisR-HSA-2029271 (Reactome)
PI3KR-HSA-2029273 (Reactome)
PKC-delta/epsilonR-HSA-198314 (Reactome)
PKC-delta/epsilonmim-catalysisR-HSA-198314 (Reactome)
PLA2G6mim-catalysisR-HSA-2029475 (Reactome)
PLC gamma1,2R-HSA-2029270 (Reactome)
PLDmim-catalysisR-HSA-2029471 (Reactome)
Phosphatidate phosphatasemim-catalysisR-HSA-2029468 (Reactome)
Phospho-PKC-delta/epsilonArrowR-HSA-198314 (Reactome)
PiArrowR-HSA-1861595 (Reactome)
PiArrowR-HSA-2029468 (Reactome)
PiArrowR-HSA-2029473 (Reactome)
PiArrowR-HSA-2029476 (Reactome)
R-HSA-167686 (Reactome) Inositol 1,4,5-triphosphate (IP3) is a second messenger produced by phospholipase C (PLC) metabolism of phosphoinositol 4,5-bisphosphate (PIP2) (Canossa et al. 2001).
R-HSA-169680 (Reactome) The IP3 receptor (IP3R) is an IP3-gated calcium channel. It is a large, homotetrameric protein, similar to other calcium channel proteins such as ryanodine. The four subunits form a 'four-leafed clover' structure arranged around the central calcium channel. Binding of ligands such as IP3 results in conformational changes in the receptor's structure that leads to channel opening.
R-HSA-169683 (Reactome) IP3 promotes the release of intracellular calcium.
R-HSA-1861595 (Reactome) Myosin-X (Myosin 10) is one of the downstream effectors of PI3K in FCGR-phagocytosis and is involved in pseudopod extension and closure of phagocytic cups. It is recruited to the forming phagosome by binding, through its second PH domain to membrane PIP3, a major product of PI3-kinase (Cox et al. 2002). Myosin-X may act as a motor to transport membrane cargo molecules to the forming pseudopods, influencing actin dynamics. It is not understood with certainty how myosin X contributes to the mechanism of pseudopod extension. It selectively binds to actin bundle such that each head may bind, in an ATP-sensitive manner, to two adjacent actin filaments within the actin bundle. Myosin X hydrolyze ATP and converts this chemical energy to mechanical energy moving toward the plus end/barbed end of the actin filament facing towards the tip of the growing pseudopods (Araki 2006, Chavrier 2003, Watanabe et al 2010).
R-HSA-1861621 (Reactome) FCGRII (CD32) is a low-affinity receptor encoded by three different genes (A, B and C) (Brooks et al. 1989). FCGRIIA functions as a single-chain transmembrane receptor containing both the ligand-binding extracellular domain and a signal transducing cytoplasmic domain that contains distinct immunoreceptor tyrosine-based activation motif (ITAM). This ITAM-like domain in FCGRIIA contains two YXXL motifs with a spacer sequence of 12 amino acids instead of the usual 7. Isoform FCGRIIB is expressed in various leukocytes, including human monocytes and, as opposed to the activating Fc receptors it has an immunoreceptor tyrosine-based inhibitory motif (ITIM) and negatively regulates phagocytosis (Van den Herik-Oudijk IE et al. 1995, Mitchell et al. 1994, Tridandapani et al. 2002).
The first step in Fc-gamma receptor (FCGR) phagocytosis is binding and clustering of FCGRs by IgG-coated foreign particles. FCGR are clustered at the cell surface by multivalent antigen-antibody complexes and recruited to lipid raft micro domains; monovalent ligand binding is insufficient to generate a signal. This cross-linking results in the localization of FCGRs into lipid rafts and this may aid in recruiting and complexing with additional signalling proteins associated with lipid rafts (Bournazos et al. 2009, Kwiatkowska & Sobota 2001, Kono et al. 2002). This is followed by phosphorylation of the tyrosine residues within the ITAM located on the cytoplasmic portion of FCGRIIA by membrane-associated tyrosine kinases of the Src family (Mitchell et al. 1994).
R-HSA-198314 (Reactome) Diacylglycerol (DAG) positively regulates the autophosphorylation of protein kinase C-delta (PKC-delta), which stimulates ERK1/2 and triggers neurite outgrowth. DAG also stimulates the translocation of PKC from the cytosol to the plasma membrane. PKC-delta contributes to growth factor specificity and response to neuronal cells by promoting cell-type-specific differences in growth factor signalling. DAG can also activate PKC-epsilon in the same manner.
R-HSA-2029268 (Reactome) PLCG is tyrosine phosphorylated by either SYK or Src kinases on three tyrosine residues and this phosphorylation enhances the activity of PLCG. Although maximal activation requires binding of PLCG to PIP3 with its plecstrin homology (PH) domain.
R-HSA-2029270 (Reactome) PLCgamma (PLCG) is recruited to FCGR and the phosphorylated Y342 and Y346 in SYK have been reported to be involved in the interaction of PLCG (Law et al. 1996). PLCG accumulates at the phagocytic cup during FCGR, but the exact role of PLCG in the regulation of phagocytosis is not clear. It may be involved in FCGR signaling by activating PKC through DAG production (Garcia-Garcia & Rosales 2002 )
R-HSA-2029271 (Reactome) Activated PI3K phosphorylates phosphatidylinositol (PI) 4-phosphate and PI 4,5-bisphosphate (PIP2) to generate PI 3,4-bisphosphate and PI 3,4,5-triphosphate (PIP3) and these second messengers recruit other signaling proteins containing plecstrin homology (PH) domain. PIP3 rapidly accumulates at sites of phagocytosis and disappears after the phagosome has been sealed off from the plasma membrane.
R-HSA-2029272 (Reactome) Activated PLCG translocates to the plasmamembrane and interacts with the inositol ring of the membrane bound phosphatidylinositol 4,5-bisphosphate (PIP2) with its PH domain. The active enzyme promotes intracelllular signaling by catalysing the hydrolysis of PIP2 to generate the second messengers IP3 and DAG.
R-HSA-2029273 (Reactome) PI3K is one of the downstream effector of activated SYK. The p85 alpha regulatory subunit of PI3K have been shown to interact with SYK and FCGRs, and transient and restricted accumulation of lipid products of the kinase have been observed at sites of the phagosomal cup (Yanagi et al. 1994, Marshall et al. 2001). Leverrier at al. has demonstrated that p110beta is the major class I catalytic isoform required for FCGR-mediated phagocytosis by primary macrophages (Leverrier at al. 2003). p85 alpha subunit interacts with phosphorylated SYK at tyrosine 317 with its C-terminal SH2 domain, whereas other tyrosine residues like 342 and 346 in the linker region may contribute to the interaction with N-terminal SH2 domain (Moon et al, 2005). The main role of PI3K in phagocytosis appears to be the regulation of pseudopod extension necessary for particle internalization and may also regulate phagocytosis through activation of ERK (Garcia-Garcia & Rosales. 2002).
R-HSA-2029445 (Reactome) FCGR mediated phagocytosis requires CDC42 to stimulate actin polymerization, generating the force for phagocytic cup protrusion or pseudopod extension. CDC42 activation is restricted at the advancing edge of the phagocytic cup, where actin is concentrated, and is deactivated at the base of the phagocytic cup (Beemiller et al 2010). The mechanism behind the recruitment and activation of CDC42 during FCGR phagocytosis is unknown. VAV regulates the activation of RAC1 but not CDC42 and the GEF responsible for CDC42 activation during FCGR-mediated phagocytosis remains unidentified (Adam et al 2004, Patel et al 2002).
R-HSA-2029449 (Reactome) Multiple sites of phosphorylation are known to exist in SYK, which both regulate its activity and also serve as docking sites for other proteins. Some of these sites include Y131 of interdomain A, Y323, Y348, and Y352 of interdomain B, and Y525 and Y526 within the activation loop of the kinase domain and Y630 in the C-terminus (Zhang et al. 2002, Lupher et al. 1998, Furlong et al. 1997). Phosphorylation of these tyrosine residues disrupts autoinhibitory interactions and results in kinase activation even in the absence of phosphorylated ITAM tyrosines (Tsang et al. 2008). SYK is primarily phosphorylated by Src family kinases and this acts as an initiating trigger by generating few molecules of activated SYK which are then involved in major SYK autophosphorylation (Hillal et al. 1997).
R-HSA-2029451 (Reactome) The organized movements of membranes and the actin cytoskeleton are coordinated in phagocytosis by small GTPases of the Rho family. Specifically, RAC1 and CDC42 are known to be stimulated upon engagement of FCGR and are essential for the extension of the pseudopods that surround and engulf the phagocytic particle (Scott et al 2005). RAC1 is known to regulate actin dynamics. It is active throughout the phagocytic cup and activated RAC1 is necessary to assemble F actin. However, closing the phagocytic cup requires RAC1 to be deactivated (Naakaya et al 2007). Deletion of RAC1 prevents FCGR mediated phagocytosis (Hall et al 2006). RAC1 activation involves transition from an inactive GDP bound to an active GTP bound state catalysed by guanine exchanges factors (GEFs). VAV has been implicated in the activation of RAC1 (Patel et al 2002).
R-HSA-2029452 (Reactome) SYK is a tyrosine kinase related to ZAP70 that is expressed in all hematopoietic cells and coimmunoprecipitates with the gamma chain associated with FCGRIIIA in macrophages and with FCERI in mast cells. SYK is very important for FCGR phagocytosis and is recruited to these phosphorylated ITAM residues through its two SRC homology 2 (SH2) domains (Agarwal et al. 1993). When SYK kinase expression is inhibited with antisense oligonucleotides both in vitro and in vivo, phagocytosis and inflammation are abolished (Matsuda et al. 1997). The domain structure of SYK comprises a regulatory region at the N-terminus consisting of a pair of SH2 domains separated by an inter-SH2 linker called interdomain A, an SH2-domain-kinase linker termed interdomain B, and a C-terminal kinase domain (Arias-Palomo et al. 2009). In resting state SYK exists in an auto-inhibited conformation by the interactions between the SH2-SH2 regulatory region and the inter-SH2 linker and the catalytic domain. This interdomain interaction reduces the conformational flexibility required by the kinase domain for catalysis (Arias-Palomo et al. 2007). Changes in the orientation of the SH2 domains could control the disruption of the auto inhibitory interactions and the activation of SYK. These movements could be totally or partially induced by the binding to phosphorylated ITAMs and/or phosphorylation of tyrosine residues in interdomain A or B (Arias-Palomo et al. 2009). Tsang et al. suggested that SYK functions as an OR-gate switch with respect to phosphorylation and ITAM binding, as either one stimulus OR the other is sufficient to cause full activation (Tsang et al. 2008).
R-HSA-2029453 (Reactome) VAV proteins exist in an auto-inhibitory state folded in such a way as to inhibit the GEF activity of its DH domain. This folding is mediated through binding of tyrosines in the acidic domain to the DH domain and through binding of the CH domain to the C1 region. Activation of VAV may involve at least three different events to relieve this auto-inhibition. Phosphorylation of the tyrosines in the acidic domain causes them to be displaced from the DH domain, binding of a ligand to the CH domain may cause it to release the C1 domain and binding of PIP3 to PH domain may alter its conformation. VAV1 is phosphorylated on Y174 in the acidic domain, and this is mediated by Syk and Src-family tyrosine kinases. Once activated, VAV1 is then involved in the activation of RAC and CDC42 downstream of FCGR.
R-HSA-2029454 (Reactome) PAK1 needs autophosphorylation for complete activation. PAK1 is autophosphorylated at several sites, but S144 flanking the kinase inhibitor region and T423 within the catalytic domain are the two conserved sites that regulate the catalytic activity (Chong et al. 2001, Parrini et al. 2001).
R-HSA-2029455 (Reactome) FCGRI is coded by three different genes (A, B, and C) and is expressed on most myeloid cells including monocytes, macrophages and dendritic cells (Allen & Seed 1988). FCGRI is a high affinity IgG receptor capable of binding monomeric IgG. FCGRI exists as a complex containing ligand (IgG) binding extracellular alpha-chain and homodimer of signal transducing FcR gamma (CD3G) chains, or a heterodimer of signal transducing FcR gamma and zeta chains (Ernst et al. 1993, Scholl & Geha 1993, van Vugt et al. 1996). The cytoplasmic domain of FCGRI does not have signaling motifs, however it is suggested that the gamma-subunit might be required for generating the phagocytic signal (Duchemin et al. 1994, Indik et al. 1995).
The first step in Fc-gamma receptor (FCGR) phagocytosis is binding and clustering of FCGRs by IgG-coated foreign particles. FCGR are clustered at the cell surface by multivalent antigen-antibody complexes and recruited to lipid raft micro domains; monovalent ligand binding is insufficient to generate a signal. This cross-linking results in the localization of FCGRs into lipid rafts and this may aid in recruiting and complexing with additional signalling proteins associated with lipid rafts (Bournazos et al. 2009, Kwiatkowska & Sobota 2001, Kono et al. 2002). This is followed by phosphorylation of the tyrosine residues with in the immuno tyrosine activation motif (ITAM) located on the cytoplasmic portion of accessory gamma/zeta chains by membrane-associated tyrosine kinases of the Src family (Duchemin et al. 1994, van Vugt et al. 1996).
R-HSA-2029456 (Reactome) PAK1, a downstream effector of CDC42 and RAC1, is found localized in phagosomes. Upon activation, PAK1 phosphorylates LIMK, which directly phosphorylates and inactivates cofilin, a protein that mediates depolymerization of actin filaments. Thus, RAC and CDC42 coordinate actin dynamics by inducing actin polymerization via ARP2/3 on one hand, and inhibiting actin depolyerization via LIMK and cofilin on the other (Garcia-Garcia & Rosales 2002).
PAK1 exists as homodimer in a trans-inhibited conformation. The kinase inhibitory (KI) domain of one PAK1 molecule binds to the C-terminal catalytic domain of the other and inhibits catalytic activity. GTPases RAC1/CDC42 bind the GBD domain of PAK1 thereby altering the conformation of the KI domain, relieving inhibition of its catalytic domain, and allowing PAK1 autophosphorylation that is required for full kinase activity (Parrini et al. 2002, Zhao & Manser 2005).
R-HSA-2029457 (Reactome) FCGRIII (CD16) is a low affinity Fc gamma receptor and is encoded by two genes (A and B), the transmembrane form FCGRIIIA and the GPI anchored FCGRIIIB (Edberg et al. 1989). Between the two isoforms FCGRIIIA is involved in phagocytosis whereas FCGRIIIB is capable of inducing calcium signalling and actin polymerisation, but its role in phagocytosis is still not clear (Garcia Garcia & Rosales 2002). FCGRIIIA is expressed in macrophages and natural killer cells as a multi chain complex consisting of a single alpha chain containing IgG binding domains and a signal transducing gamma and/or zeta dimer (Wirthmuller et al. 1992, Lanier et al. 1989). Both gamma and zeta chains contain a conserved immunoreceptor tyrosine based activation motif (ITAM), which has 2 copies of the YXXL sequence (Isakov 1997). However, the gamma chain of FCGRIIIA is approximately sixfold more efficient in mediating phagocytosis than the zeta subunit (Park & Schreiber 1995). Phosphorylation of the conserved tyrosine residues of the ITAM in these accessory proteins is required for the phagocytic signal mediated by FCRGIIIA.
The first step in Fc-gamma receptor (FCGR) phagocytosis is binding and clustering of FCGRs by IgG-coated foreign particles. FCGR are clustered at the cell surface by multivalent antigen-antibody complexes and recruited to lipid raft micro domains; monovalent ligand binding is insufficient to generate a signal.
This cross linking results in the localisation of FCGRs into lipid rafts and this may aid in their recruiting and complexing with additional signalling proteins associated with lipid rafts (Kono et al. 2002). This is followed by phosphorylation of the tyrosine residues within the ITAM located on the cytoplasmic portion of accessory gamma/zeta chains by membrane associated tyrosine kinases of the Src family (Park et al. 1993).
R-HSA-2029458 (Reactome) VAV family members are cytoplasmic guanine nucleotide exchange factors (GEFs) for Rho-family GTPases (RAC, RHO and CDC42). VAV1 is found predominantly in hematopoietic cells, whereas VAV2 and VAV3 are more broadly expressed. VAV proteins link the cell surface receptors like FCGR to the intracellular Rho GTPases and the actin cytoskeleton during phagocytosis (Hall et al 2006). Experiments using two-hybrid system suggest that VAV1 with its SH2 domain directly binds to the phosphorylated Y342 of SYK (Deckert et al. 1996). VAV proteins are also recruited to membrane through their PH domain by binding PI(3,4,5)P3 produced by PI3K.
R-HSA-2029459 (Reactome) After cross linking, Fc gamma receptors are sequestered to lipid rafts where they are complexed with some of the tyrosine kinases of Src family and undergo phosphorylation on the tyrosine residues contained in conserved ITAM sequences. At least six out of nine members of the Src family kinases (SRC, FYN, FGR, HCK, YES and LYN ) have been identified in the phagocytic cells and are implicated in the initiation of Fc gamma mediated signaling. (Suzuki et al. 2000, Majeed et al. 2001, Kwiatkowska et al. 2003). Some of these kinases have been found associated with specific receptors. In monocytes HCK and LYN have been found associated with FCGRI (Durden et al. 1995), whereas only HCK with FCGRIIA (Ghazizadeh et al. 1994) while FGR in neutrophils (Hamada et al. 1993) and LCK in NK cells with FCGRIIIA (Pignata et al. 1993)
The implication of Src kinases in phosphorylation was first supported by pharmacological findings that herbimycin A, a tyrosine kinase inhibitor relatively specific for Src-family kinases, potently suppressed Fc receptor mediated functions (Greenberg et al. 1993, Suzuki et al. 2000). However, their particular involvement in phagocytosis remains unclear, as targeted disruption of single or multiple Src family genes did not result in significant alterations in phagocytosis (Hunter et al. 1993, Fitzer Attas et al. 2000, Suzuki et al. 2000). HCK, FGR and LYN triple-deficient (-/-) macrophages have shown significant delays in FCGR mediated phagocytosis, but these deficiencies do not completly disrupt the process (Fitzer Attas et al. 2000).
Tyrosine residues Y288 and Y304 (Y282 and Y298 according to the literature reference, it is 6 residues shorter compared to uniprot entry due to an alternate initiation codon usage), within ITAM sequence in the cytoplasmic domain of FCGRIIA are the key target sites that are phosphorylated by Src family kinases (Mitchell et al, 1994). In case of FCGRIA and FCGRIIIA the specific tyrosine residues within ITAMs of the associated gamma/zeta chains are phosphorylated by activated Src family kinases (SFKs) (Park et al. 1993).
R-HSA-2029460 (Reactome) LIM kinases are serine protein kinases with a unique combination of two N-terminal LIM motifs, a central PDZ domain, and a C-terminal protein kinase domain. LIMK1 is one of the downstream targets of PAK1 and is activated through phosphorylation by PAK1 on T508 within its activation loop (Edwards et al. 1999, Aizawa et al. 2001). LIM-kinase is responsible for the tight regulation of the activity of cofilin (a protein that depolymerizes actin filaments) and thus maintains the balance between actin assembly and disassembly. Phosphorylated cofilin is inactive, resulting in stabilization of the actin cytoskeleton.
R-HSA-2029465 (Reactome) WASP family verprolin-homologous proteins (WAVEs) function downstream of RAC1 and are involved in activation of the ARP2/3 complex. The resulting actin polymerization mediates the projection of the plasma membrane in lamellipodia and membrane ruffles. WAVEs exist as a pentameric hetero-complex called WAVE Regulatory Complex (WRC). The WRC consists of a WAVE family protein (WASF1, WASF2 or WASF3 - commonly known as WAVE1, WAVE2 or WAVE3), ABI (Abelson-interacting protein), NCKAP1 (NAP1, p125NAP1), CYFIP1 (SRA1) or the closely related CYFIP2 (PIR121), and BRK1 (HSPC300, BRICK). Of the three structurally conserved WAVEs in mammals, the importance of WAVE2 in activation of the ARP2/3 complex and the consequent formation of branched actin filaments is best established. WAVEs in the WRC are intrinsically inactive and are stimulated by RAC1 GTPase and phosphatidylinositols (PIP3). The C-terminal VCA domain of WAVE2 (and likely WAVE1 and WAVE3) which can bind both the ARP2/3 complex and actin monomers (G-actin) is masked in the inactive state. After PIP3 binds to the polybasic region of WAVE2 (and likely WAVE1 and WAVE3) and RAC1:GTP binds to the CYFIP1 (or CYFIP2) subunit of the WRC, allosteric changes most likely occur which allow WAVEs to interact with the ARP2/3 complex. The interactions between WAVEs and RAC1 are indirect. BAIAP2/IRSp53, an insulin receptor substrate, acts as a linker, binding both activated RAC1 and the proline-rich region of WAVE2 (and likely WAVE1 and WAVE3) and forming a trimolecular complex. CYFIP1 (or CYFIP2) in the WAVE regulatory complex binds directly to RAC1:GTP and links it to WAVE2 (and likely WAVE1 and WAVE3) (Derivery et al. 2009, Yamazaki et al. 2006, Takenawa & Suetsugu 2007, Chen et al. 2010, Pollard 2007, Lebensohn & Kirschner 2009).
R-HSA-2029466 (Reactome) Once activated, the ARP2/3 complex nucleates new actin filaments that extend from the sides of pre-existing mother actin filaments at a 70-degree angle to form Y-branched networks (Firat-Karalar & Welch 2010). These branched actin filaments push the cell membrane forward to form a pseudopod. The ARP2/3 complex is composed of two Arps (actin-related proteins), ARP2 and ARP3, and five unique proteins ARPC1, ARPC2, ARPC3, ARPC4 and ARPC5 (Gournier et al. 2001). Both ARP2 and ARP3 subunits bind ATP. There are two proposed models to explain the process of actin nucleation by ARP2/3 complex: the barbed-end branching model and the dendritic nucleation/side branching model (Le Clainche & Carlier 2008).
In barbed-end branching model, the branching/ternary complex (G-actin-WASP/WAVE-Arp2/3 complex) binds to the barbed end of the mother filament. G-actin bound to VCA domain or one of the Arp subunits incorporates into the mother filament at the barbed end, thus positioning ARP2/3 complex to initiate the daughter branch on the side of the mother filament. ARP2/3 nucleates the formation of new actin filament branches, which elongate at the barbed ends (Le Clainche & Carlier 2008, Pantaloni et al 2000, Le Clainche et al. 2003, Egile et al. 2005). In side branching model, the branching complex binds to the side of the mother actin filament mimicking an actin nucleus and initiates a lateral branch (Le Clainche & Carlier 2008, Amann & Pollard 2001).
R-HSA-2029467 (Reactome) RAC1 is activated from inactive GDP-bound state to active GTP-bound form by the GEF activity of DOCK180:ELMO complex.
R-HSA-2029468 (Reactome) Phosphatidic acid phosphatase (PAP) bound to the plasma membrane catalyzes the dephosphorylation of phosphatidic acid (PA), yielding diacylglycerol (DAG) and inorganic phosphate. In humans, Diacylglycerol pyrophosphate (DPPL1 and DPPL2) perform this reaction.
R-HSA-2029469 (Reactome) The ARP2/3 complex shows higher affinity for the phosphorylated VCA domain of WAVE2 than for the unphosphorylated VCA domain. WAVE proteins can be phosphorylated by various kinases. Active ERK (Mitogen activated protein kinase 3) phosphorylates the WAVE regulatory complex (WRC) on multiple serine/threonine sites within the proline-rich domains (PRDs) of WAVE2 and ABI1. Phosphorylation of the PRDs would disrupt their interaction with SH3 and PLP binding domains, potentially altering WRC activation. ERK phosphorylates both S343 and T346 in WAVE2 and S183, S216, S225, S392, and S410 in ABI1. Cumulatively, the phosphorylation of both WAVE2 and ABI in the WAVE regulatory complex (WRC) contributes to the RAC-induced WRC conformational change that exposes the VCA domain, leading to binding and activation of ARP2/3 (Mendoza et al. 2011, Nakanishi et al. 2007). ERK phosphorylation sites in WAVE2 are not strictly conserved in WAVE1 and WAVE3 but, based on the amino acid sequence, other potential ERK phosphorylation sites exist.
R-HSA-2029471 (Reactome) Phospholipase D (PLD) catalyses the hydrolysis of the membrane phospholipid, phosphatidylcholine (PC) to generate choline and metabolically active phosphatidic acid (PA) (Lennartz 1999). Pharmacological inhibition studies show that PLD participates in FCGR-mediated phagocytosis (Kusner et al. 1996). There is an increase in the activity of PLD following the activation of phagocytosis via FCGR (Kusner et al. 1999). Following activation of FCGR, PLD translocates to the plasma membrane at the phagocytic cup and generate PA. This PA can be converted to DAG through the action of phosphatidic acid phosphatase-1 (PAP-1). Thus activation of PLD may be an additional pathway leading to PKC activation.
The two isoforms PLD1 and PLD2 are both shown to be essential for the formation of phagosome at different stages. PLD1 is localized on the endosomal/lysosomal compartment and PLD2 is localized at the plasma membrane. PLD2 may be linked to phagosome formation whereas PLD1 may be involved in the focal exocytosis at the plasma membrane and also in the maturation process (Carrotte et al. 2006).
R-HSA-2029473 (Reactome) ATP bound G-actin monomers are added to the fast growing barbed ends of both mother and daughter filaments and the polymerization of these filaments drives membrane protrusion. In the process of phagocytosis, pseudopodia extend around the antibody-bound particle to form the phagocytic cup. This elongation continues until the filament reaches steady state equilibrium with free G-actin monomers (Millard et al. 2004, Le Clainche et al. 2008).
R-HSA-2029475 (Reactome) Several members of phospholipase A (PLA) are involved in phagocytosis. Macrophages express three classes of PLA2: secreted Ca-dependent (sPLA2), cytosolic Ca-dependent (cPLA2) and cytosolic Ca-independent (iPLA2) of which iPLA2 is involved in FCGR mediated arachidonic acid (AA) production. Aggregation of FCGR triggers phosphorylation and membrane translocation of iPLA2. Protein kinase C (PKC), ERK and p38MAPK seems to regulate iPLA2 in monocytes, neutrophils and macrophages. Phosphorylated iPLA2 then mediates production of AA and lysoophospholipids from phosphatidylcholine. iPLA2 inhibitors (bromoenol lactone) block AA release and phagocytosis which can be restored upon addition of exogenous AA, suggesting a critical role for iPLA2 in FCGR phagocytosis (Lennartz et al. 1993, Tay & Melendez). Release of AA by activated iPLA2 changes the physical characteristic of the membrane which may facilitate pseudopod extension.
R-HSA-2029476 (Reactome) In addition to the membrane remodeling for pseudopod extension, particle internalization requires a contractility force pulling the forming phagosome into the cytoplasm. Myosin motor proteins are the actin-binding proteins, with ATPase activity move along actin fibers, and produce the driving force for phagosome formation and transport. Several myosin motors including myosins IC, II, V, IXb are involved in FCGR-mediated phagocytosis as force generators and actin-based transport motors (Swanson et al. 1999). Nonmuscle myosin II, is a motor protein known to generate intracellular contractile forces and tension by associating with F-actin. It has been observed to localize around forming phagosomes and suggested a role in phagocytic-cup squeezing during FCGR-mediated phagocytosis. Each myosin II motor protein exists as a complex consisting of two copies each of myosin II heavy chain (MHC), essential light chains (ELC), and myosin regulatory light chain (MRLC). Selective inhibition of myosin II by ML-7, a myosin light-chain kinase (MLCK) inhibitor, prevents phagocytic cup closure, but not pseudopod extension for the formation of phagocytic cups in FCGR-mediated phagocytosis (Grooves et al. 2008, Araki 2006). Tight ring of actin filaments within the elongating pseudopodia squeezes the deformable particles. In the classical zipper model for phagocytosis, the pseudopod extends over the IgG-coated particles, in which FCGRs in the phagocyte plasma membrane interact sequentially with Fc portions of IgG molecules zippering the membrane along the particle. This sequential IgG-FCGR binding might not occur by itself, but requires forced zipper closure, where myosin-II contractile activity may promote the binding between the FCGR and its ligands, to facilitate the efficient extension and subsequent closure of phagocytic cups (Araki 2006, ). Myosin IC mediates the purse-string-like contraction that closes phagosomes. Myosin-V has been implicated in membrane trafficking events (Swanson et al. 1999).
R-HSA-2130194 (Reactome) Abelson interactor-1 (ABL) tyrosine kinase phosphorylates the strictly conserved tyrosine 150 in WAVE2 (Y151 in WAVE1 and WAVE3) (Leng et al. 2003, Chen et al. 2010).
R-HSA-2197690 (Reactome) After incorporation at the branch, the actin bound to VCA domain of WASP/WAVE undergoes ATP hydrolysis and this destabilizes its interaction with WASP/WAVE. This dissociates the branched junction from the membrane-bound WASP/WAVE (Kovar 2006).
R-HSA-2197691 (Reactome) WASP interacting proteins (WIP) family includes WIPF1 (WIP), WIPF2 (WIRE,WICH) and WIPF3 (CR16, corticosteroids and regional expression-16). WIPs share a specific proline rich sequence that interacts with the WH1 domain of WASP and N-WASP (WASL). WIPs form heterocomplexes with WASPs and may contribute to the WASP protein stability (Aspenstrom 2002, Kato et al. 2002, Ho et al. 2001, Moreau et al. 2000).
SH3 domain containing adaptor proteins like GRB2 (Carlier et al. 2000), NCK (Rohatgi et al. 2001) and WISH (DIP/SPIN90) (Fukuoka et al. 2001) bind to the proline rich domain in WASPs and activate the ARP2/3 complex. By binding simultaneously to N-WASP and the ARP2/3 complex, GRB2 works synergistically with CDC42 in the activation of ARP2/3 complex-mediated actin assembly (Carlier et al. 2000).
R-HSA-2197697 (Reactome) Macrophages lacking all the three isoforms of VAV did not affect FCGR-mediated phagocytosis suggesting that RAC1 is regulated by GEFs other than VAV downstream of the FCGR (Hall et al 2006). DOCK180, a member of GEFs, is found to be involved in the activation of RAC1. DOCK180 associates with the adaptor protein CRKII and the complex is found to accumulate at the phagocytic cup. DOCK180 is recruited to the sites of phagocytosis by binding to SH3 domain of CRKII through its proline-rich motif (Hasegawa et al 1996). CRKII is likely recruited to the activated FCGR complex by binding phosphorylated ITAM tyrosines on the receptor or through other phosphotyrosines on ancillary proteins that are recruited to the receptor complex (Lee et al 2007). Unlike the usual GEFs, DOCK180 does not contain the conserved Dbl homology (DH) domain. Instead, it has a DHR-2 or DOCKER domain capable of loading RAC with GTP (Brugnera et al 2002). Binding of DOCK180 to RAC alone is insufficient for GTP loading, and a DOCK180-ELMO interaction is required. ELMO1, as well as ELMO2, form a complex with DOCK180 and they function together as a bipartite GEF to optimally activate RAC (Gumienny et al 2001, Brugnera et al 2002).
R-HSA-2197698 (Reactome) WASP is phosphorylated on Tyr291 (Cory et al. 2002) and N-WASP (WASL) on Tyr256 (Wu et al. 2004) by Src family of tyrosine kinases and this phosphorylation may release the autoinhibitory intramolecular interactions. The phosphorylation seems to be enhanced by the activation of CDC42. WASP phosphorylation and binding of CDC42 have a synergistic effect on the activation of the ARP2/3 complex (Takenawa & Suetsugu 2007). In N-WASP, the phosphorylation may reduce its nuclear translocation and may sustain it in its functional site in the cytoplasm (Wu et al. 2004).
R-HSA-399950 (Reactome) The EPHB2-FAK pathway partially promotes dendritic spine stability through LIMK-mediated cofilin (CFL1) phosphorylation (Shi et al. 2009). CFL1 is a member of the ADF (actin-depolymerizing factor) protein family that is involved in regulating actin dynamics in the growth cone. It binds to actin in a one-to-one molar ratio, and stimulates both the severing of actin filaments and depolymerization of actin subunits from the actin filament end. Activated LIMK phosphorylates CFL1 on the conserved serine 3 residue located near the actin-binding site. After phosphorylation, CFL1 is inactive, loses its affinity for actin and dissociates from G-actin monomers. Once freed, ADP-actin monomers can exchange ADP with cytoplasmic ATP, ready for reincorporation at the barbed end of a growing filament (Gungabissoon & Bamburg 2003).
R-HSA-419644 (Reactome) Binding of Hsp90 to the LIMK proteins protects them from degradation and promotes their dimer formation and transphosphorylation. It is estimated that LIMK1 contains at least 5 phospho-amino acids primarily phospho-serines, in its kinase domain. The positions of these serine residues are not known. Transphosphorylation of these serine residues in LIMK1 increases its stability.
R-HSA-419645 (Reactome) After phosphorylation on Thr 508, LIMK undergoes homodimerization. Homodimer formation is promoted by the binding of heat shock protein 90 (Hsp90) to a short sequence in the kinase domain of LIMKs. LIMKs are further phosphorylated after homodimer formation and transphosphorylation of the kinase domain.
R-HSA-442586 (Reactome) Wiskott-Aldrich syndrome protein (WASP) and Neural-WASP (N-WASP, WASL) proteins are scaffolds that transduce signals from cell surface receptors to the activation of the ARP2/3 complex and actin polymerization. WASP and N-WASP possess a central GTPase binding domain (GBD) and an NH2-terminal WASP homology domain 1 (WH1) followed by a basic region (B), and a C-terminal VCA region that contains: a V domain (verprolin homology/WASP homology 2), a C domain (connecting), and an A motif (acidic). The VCA region is responsible for binding to and activating the ARP2/3 complex (Bompard & Caron 2004, Callebaut et al 1998). Under resting conditions, WASP and N-WASP are maintained in an autoinhibited state via interaction of the GBD and the VCA domains. This prevents access of the ARP2/3 complex and G-actin to the VCA region. Activated CDC42 binds to the GBD region of WASPs and this interaction releases the VCA region from autoinhibition, enabling binding of the ARP2/3 complex and stimulating actin polymerization (Kim et al 2000, Park & Cox 2009). Phosphoinositides (PtdIns(4,5)P2) interact with the basic (B) region in WASPs and this interaction is important for activation of the WASPs and the ARP2/3 complex (Higgs & Pollard 2000).
R-HSA-442592 (Reactome) Once WASPs (WASP and N-WASP) and WAVEs (WAVE2 and probably WAVE1 and WAVE3) are activated, their VCA region becomes available for binding to the ARP2/3 complex and actin monomer (G-actin). The actin monomer binds to the V domain and ARP2/3 complex binds to the CA domain. The simultaneous binding of G-actin and the ARP2/3 complex to the VCA region contributes to the activation of the ARP2/3-complex-mediated actin polymerization. The VCA module acts as a platform on which an actin monomer binds to the ARP2/3 complex to trigger actin polymerization (Takenawa & Suetsugu 2007).
RAC1/CDC42:PAK dimerArrowR-HSA-2029456 (Reactome)
RAC1/CDC42:PAK dimerR-HSA-2029454 (Reactome)
RAC1/CDC42:p-S144,T423-PAKArrowR-HSA-2029454 (Reactome)
RAC1:GDPR-HSA-2029451 (Reactome)
RAC1:GDPR-HSA-2029467 (Reactome)
RAC1:GTPArrowR-HSA-2029451 (Reactome)
RAC1:GTPArrowR-HSA-2029467 (Reactome)
RAC1:GTPR-HSA-2029465 (Reactome)
SH3 domain proteinsR-HSA-2197691 (Reactome)
SYKR-HSA-2029452 (Reactome)
Src family kinases (SFKs)mim-catalysisR-HSA-2029459 (Reactome)
Src-kinasesmim-catalysisR-HSA-2197698 (Reactome)
VAV1,2,3R-HSA-2029458 (Reactome)
WASP/N-WASPR-HSA-442586 (Reactome)
WAVE Regulatory ComplexR-HSA-2029465 (Reactome)
WIP family proteinsR-HSA-2197691 (Reactome)
WRC:IRSp53/58:RAC1:GTP:PIP3ArrowR-HSA-2029465 (Reactome)
WRC:IRSp53/58:RAC1:GTP:PIP3R-HSA-2130194 (Reactome)
clustered IgG-Ag:FCGRsR-HSA-2029459 (Reactome)
clustered IgG-Ag:p-FCGRs:SYKArrowR-HSA-2029452 (Reactome)
clustered IgG-Ag:p-FCGRs:SYKR-HSA-2029449 (Reactome)
clustered IgG-Ag:p-FCGRs:SYKmim-catalysisR-HSA-2029449 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCGArrowR-HSA-2029270 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCGR-HSA-2029268 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCGmim-catalysisR-HSA-2029268 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAVArrowR-HSA-2029458 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAVR-HSA-2029453 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCGArrowR-HSA-2029268 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCGR-HSA-2029272 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-VAVArrowR-HSA-2029453 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-VAVmim-catalysisR-HSA-2029451 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYKArrowR-HSA-2029272 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYKArrowR-HSA-2029449 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYKR-HSA-2029270 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYKR-HSA-2029273 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYKR-HSA-2029458 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYKR-HSA-2197697 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYKmim-catalysisR-HSA-2029453 (Reactome)
clustered IgG-Ag:p-FCGRsArrowR-HSA-2029459 (Reactome)
clustered IgG-Ag:p-FCGRsArrowR-HSA-2029476 (Reactome)
clustered IgG-Ag:p-FCGRsR-HSA-2029452 (Reactome)
clustered IgG-Ag:p-FCGRsR-HSA-2029476 (Reactome)
p-4Y-PLCG1mim-catalysisR-HSA-167686 (Reactome)
p-PLCGArrowR-HSA-2029272 (Reactome)
p-S144,T423-PAK1ArrowR-HSA-2029454 (Reactome)
p-S144,T423-PAK1mim-catalysisR-HSA-2029460 (Reactome)
p-T,Y MAPK dimersmim-catalysisR-HSA-2029469 (Reactome)
p-T508-LIMK1ArrowR-HSA-2029460 (Reactome)
p-T508-LIMK1R-HSA-419645 (Reactome)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3ArrowR-HSA-2029469 (Reactome)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3ArrowR-HSA-2130194 (Reactome)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3R-HSA-2029469 (Reactome)
pCofilin: Active LIMK-1ArrowR-HSA-399950 (Reactome)
pLIMK dimer:HSP-90ArrowR-HSA-419645 (Reactome)
pLIMK dimer:HSP-90R-HSA-419644 (Reactome)
pLIMK dimer:HSP-90mim-catalysisR-HSA-419644 (Reactome)
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