Cannabinoid receptor signaling (Homo sapiens)

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6endogenous cannabinoidsHepG2 cellsLeukocytes, spleen, thymus, bone marrowand other tissues associated with immune functionsInhibition of Glutamate or GABA release in synaptic cleftinactiveNeuronal cell of CNS(hyppocampus, cerebellum or basal ganglia)DAGLAFAAHMAPK GlutamateNAPENAPEPLD2-arachidonoylglycerolATPCNR2CNR1cAMP AEAPKACYP2C9ADCY1Anti-inflammatory pathwaysTHCDAGLBOH-CBDsPhosphatidylethanolamineCOOH-THCADCY7protein tyrosine kinasesCYP3A4CYP2C19Calcium?11-OH-THCAHRADORA2ACYP1A1GABA CBD51742434PKAATPcAMP


Description

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Díaz-Alonso J, Guzmán M, Galve-Roperh I; ''Endocannabinoids via CB� receptors act as neurogenic niche cues during cortical development.''; Philos Trans R Soc Lond B Biol Sci, 2012 PubMed Europe PMC Scholia
  2. Anderson GD, Chan LN; ''Pharmacokinetic Drug Interactions with Tobacco, Cannabinoids and Smoking Cessation Products.''; Clin Pharmacokinet, 2016 PubMed Europe PMC Scholia
  3. Yamaori S, Kinugasa Y, Jiang R, Takeda S, Yamamoto I, Watanabe K; ''Cannabidiol induces expression of human cytochrome P450 1A1 that is possibly mediated through aryl hydrocarbon receptor signaling in HepG2 cells.''; Life Sci, 2015 PubMed Europe PMC Scholia
  4. Carrier EJ, Auchampach JA, Hillard CJ; ''Inhibition of an equilibrative nucleoside transporter by cannabidiol: a mechanism of cannabinoid immunosuppression.''; Proc Natl Acad Sci U S A, 2006 PubMed Europe PMC Scholia
  5. Laprairie RB, Bagher AM, Kelly ME, Denovan-Wright EM; ''Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor.''; Br J Pharmacol, 2015 PubMed Europe PMC Scholia
  6. Jiang R, Yamaori S, Takeda S, Yamamoto I, Watanabe K; ''Identification of cytochrome P450 enzymes responsible for metabolism of cannabidiol by human liver microsomes.''; Life Sci, 2011 PubMed Europe PMC Scholia
  7. ; ''''; http://www.genecards.org/cgi-bin/carddisp.pl?gene=CNR2&keywords=cnr2,

History

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CompareRevisionActionTimeUserComment
118463view15:04, 27 May 2021FinterlyMoved URL to Source for rdf:id b2b
106148view12:04, 16 August 2019MaintBotHMDB identifier normalization
98007view07:54, 3 July 2018Fehrhartfixed aesthetics
97566view07:39, 25 May 2018IreneHemelModified description
97565view07:39, 25 May 2018IreneHemelModified description
97564view07:36, 25 May 2018IreneHemelAddition of relevant MAPK subtypes
97536view14:31, 24 May 2018IreneHemelSubunits PKA
94926view11:40, 13 October 2017DeSlOntology Term : 'xenobiotic metabolic pathway' added !
94925view11:38, 13 October 2017DeSladded ID for 2nd PKA node
94924view11:37, 13 October 2017DeSladded ID for PKA
94923view11:36, 13 October 2017DeSladded ID for MAPK
88989view11:44, 18 August 2016Mkutmonremoved comments
88980view09:30, 18 August 2016Fehrhartfixed some weird characters
88978view09:18, 18 August 2016Fehrhartadjusted some lines and added descriptions
88975view09:12, 18 August 2016Fehrhartaddition of OH-CBDs
88973view08:36, 18 August 2016FehrhartModified description
88834view13:13, 15 August 2016Fehrhartwork in progress
88833view13:10, 15 August 2016FehrhartModified description
88598view19:51, 11 August 2016Mkutmonfix unconnected lines
88457view14:38, 9 August 2016Fehrhartwork in progress
88450view15:07, 8 August 2016Fehrhartwork in progress
88449view15:02, 8 August 2016Fehrhartadded CYP1A1 stimulation pathway
88389view13:24, 3 August 2016FehrhartOntology Term : 'leukocyte' added !
88388view13:24, 3 August 2016FehrhartOntology Term : 'neuron' added !
88387view13:23, 3 August 2016FehrhartOntology Term : 'cannabinoid signaling pathway' added !
88386view13:22, 3 August 2016FehrhartWork in progress
88383view12:53, 3 August 2016FehrhartNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
11-OH-THCMetaboliteHMDB60906 (HMDB)
2-arachidonoylglycerolMetaboliteHMDB04666 (HMDB)
?Metabolite
ADCY1GeneProductENSG00000164742 (Ensembl)
ADCY7GeneProductENSG00000121281 (Ensembl)
ADORA2AGeneProductENSG00000128271 (Ensembl)
AEAMetaboliteHMDB04080 (HMDB)
AHRGeneProductENSG00000106546 (Ensembl)
ATPMetaboliteHMDB00538 (HMDB)
Anti-inflammatory pathwaysPathway
CBDMetaboliteCHEBI:69478 (ChEBI)
CNR1GeneProductENSG00000118432 (Ensembl)
CNR2GeneProductENSG00000188822 (Ensembl)
COOH-THCMetaboliteCHEBI:77273 (ChEBI) 22-nor-9-carboxy- D9-tetrahydrocannabinol (COOH-THC) - CheBI Identifier is for11-nor-9-carboxy-Δ9-tetrahydrocannabinol
CYP1A1GeneProductENSG00000140465 (Ensembl)
CYP2C19GeneProductENSG00000165841 (Ensembl)
CYP2C9GeneProductENSG00000138109 (Ensembl)
CYP3A4GeneProductENSG00000160868 (Ensembl)
CalciumMetaboliteHMDB00464 (HMDB)
DAGLAGeneProductENSG00000134780 (Ensembl)
DAGLBGeneProductENSG00000164535 (Ensembl)
FAAHGeneProductENSG00000117480 (Ensembl)
GABA MetaboliteHMDB00112 (HMDB)
GlutamateMetaboliteHMDB00148 (HMDB)
MAPK GeneProduct
NAPEMetaboliteCHEBI:61232 (ChEBI)
NAPEPLDGeneProductENSG00000161048 (Ensembl)
OH-CBDsMetabolite
  • 6α-OH-, 6β-OH-, 7-OH-, 1″-OH-, 2″-OH-, 3″-OH-, 4″-OH-, and 5″-OH-CBDs
  • no identifier available yet
PKAGeneProduct
PhosphatidylethanolamineMetaboliteHMDB60501 (HMDB)
THCMetaboliteHMDB41865 (HMDB)
cAMP MetaboliteHMDB00058 (HMDB)
protein tyrosine kinasesPathway

Annotated Interactions

No annotated interactions

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