Humoral immune response to fungal and bacterial pathogens (Drosophila melanogaster)

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1TranscriptionPlasmatocyteFungal B-1-3-glucansFungal and Bacterial Virulence FactorsDegradedDap Type PPGThiolester ProteinsLysine type PPGAntimicrobial PeptidesFat Body Cellp100p105FaddTak1IKKGMyd88Tab2PGRP-SDGNBP3Caspase-8DorsalSerine protease persephoneDiap2SPEDomelessPGRP-SAStatSpatimdIKKBupd3Protein tollPGRP-LCimdProtein TubeDifNF-kappa-B inhibitor cactusSerine/threonine-protein kinase pelleJNKJakGNBP1JakStatStatStat


Description

Pathways regulating Drosophila's humoral response to bacterial and fungal pathogens. Pathogens such as fungal B-1-3-glucans and virulence factors illicit signalling pathways through receptors on body fat cells of Drosophila Melanogaster (Protein Toll, PGRP-LC, and Domeless). The activation of receptors initiates pathways that increase transcription of antimicrobial agents and thioester proteins. This pathway is based on figure 1 from Igboin et al.

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Ontology Terms

 

Bibliography

  1. Igboin CO, Griffen AL, Leys EJ; ''The Drosophila melanogaster host model.''; J Oral Microbiol, 2012 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
116924view09:44, 16 May 2021EweitzModified title
90080view05:03, 13 October 2016Khanspersoverhaul
90079view23:52, 12 October 2016KhanspersModified title
88668view15:31, 12 August 2016JmeliusOntology Term : 'immune response pathway' added !
88667view15:31, 12 August 2016JmeliusOntology Term : 'PW:0000004' removed !
88666view15:31, 12 August 2016JmeliusOntology Term : 'regulatory pathway' added !
85929view18:26, 21 June 2016AAR&CoModified description
85823view19:22, 15 June 2016AAR&CoModified description
85822view18:57, 15 June 2016AAR&CoNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Caspase-8ProteinQ8IRY7 (Uniprot-TrEMBL)
Diap2GeneProductFBgn0015247 (Ensembl)
DifGeneProductFBgn0011274 (Ensembl)
DomelessGeneProductFBgn0043903 (Ensembl)
DorsalProteinC7LA93 (Uniprot-TrEMBL) Dorsal Not Specified
FaddGeneProductFBgn0038928 (Ensembl)
GNBP1GeneProductFBgn0040323 (Ensembl)
GNBP3GeneProductFBgn0040321 (Ensembl)
IKKBGeneProductFBgn0024222 (Ensembl)
IKKGGeneProductFBgn0041205 (Ensembl)
JNKProteinP92208 (Uniprot-TrEMBL)
JakGeneProductFBgn0004864 (Ensembl)
Myd88GeneProductFBgn0033402 (Ensembl)
NF-kappa-B inhibitor cactusProteinQ03017 (Uniprot-TrEMBL)
PGRP-LCGeneProductFBgn0035976 (Ensembl)
PGRP-SAGeneProductFBgn0030310 (Ensembl)
PGRP-SDGeneProductFBgn0035806 (Ensembl)
Protein TubeProteinP22812 (Uniprot-TrEMBL)
Protein tollProteinP08953 (Uniprot-TrEMBL)
SPEGeneProductFBgn0039102 (Ensembl)
Serine protease persephoneProteinQ9VWU1 (Uniprot-TrEMBL)
Serine/threonine-protein kinase pelleProteinQ05652 (Uniprot-TrEMBL)
SpatGeneProductFBgn0014031 (Ensembl)
StatGeneProductFBgn0016917 (Ensembl)
Tab2GeneProductFBgn0086358 (Ensembl)
Tak1GeneProductFBgn0026323 (Ensembl)
imdGeneProductFBgn0013983 (Ensembl)
p100GeneProductFBgn0035121 (Ensembl)
p105ProteinA1Z898 (Uniprot-TrEMBL)
upd3GeneProductFBgn0053542 (Ensembl)

Annotated Interactions

No annotated interactions

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