Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)

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27, 59, 74, 9121, 54, 869, 297, 53, 8719, 3417, 22, 32, 49, 56...68353, 51687919, 34, 8412, 5216, 895, 9015, 42, 7358, 7138, 481, 10, 18, 28, 65...13, 24, 36, 55, 72...20, 33, 47, 692, 6461, 633, 30, 5118, 8035, 45, 624, 3711, 2644, 57, 81388, 436, 14, 41, 46, 50...40, 6723, 25, 59, 60, 8510, 287766, 76phagocytic cupcytosolendoplasmic reticulum lumenIg lambda chain V-III region SH Ig lambda chain V-II region NEI MYH9 BAIAP2 Ig heavy chain V-II region COR Ig kappa chain V-I region Walker Ig lambda chain V-II region BOH Ig lambda chain V-VI region SUT Ig lambda chain V-IV region MOL Ig kappa chain V-IV region JI Ig heavy chain V-III region JON Ig kappa chain V-II region RPMI 6410 Ig kappa chain V-II region GM607 IGLC1 PLCG1 IGLV4-69(1-?) Ig lambda chain V-II region WIN Ig heavy chain V-III region TRO WIPF3 ACTB(1-375) Ig kappa chain V-I region DEE IGLV3-22(1-?) ATPIGLV3-27(1-?) Ig heavy chain V-II region ARH-77 Ig lambda chain V-IV region Hil Ig kappa chain V-I region Mev Ig heavy chain V-I region WOL Ig heavy chain V-III region KOL Ig heavy chain V-II region DAW Ig kappa chain V-III region NG9 Ig kappa chain V-III region CLL Ig heavy chain V-III region WAS Ig heavy chain V-III region HIL IGKV4-1(21-?) Ig heavy chain V-III region KOL Ig lambda chain V-I region EPS Ig lambda chain V-III region LOI Ig heavy chain V-I region EU Ig lambda chain V-IV region MOL IGKV4-1(21-?) IGLV5-45(1-?) Ig kappa chain V-I region Daudi Ig heavy chain V-II region NEWM BAIAP2 Ig lambda chain V-II region BUR ABI2 Ig kappa chain V-III region SIE p-5S-ABI1 Ig kappa chain V-III region POM Ig lambda chain V-I region MEM Ig kappa chain V-I region AG ITPR3 Ig heavy chain V-III region JON Ig lambda chain V-VI region WLT Ig kappa chain V-III region WOL Ig kappa chain V-III region CLL IGLV4-69(1-?) Ig lambda chain V-IV region MOL BAIAP2 Ig lambda chain V-I region HA Ig heavy chain V-II region DAW IGHV7-81(1-?) Ig heavy chain V-III region LAY Ig lambda chain V-VI region AR Ig lambda chain V-I region EPS Ig kappa chain V-I region AU IGHG3 Ig heavy chain V-I region ND IGLV3-27(1-?) IGKV4-1(21-?) Ig lambda chain V-II region NIG-84 Ig kappa chain V-II region TEW Ig lambda chain V-II region NIG-84 Ig kappa chain V-I region AG Ig heavy chain V-I region SIE Ig kappa chain V-I region EU CD3G CYFIP2 PI(4,5)P2 Ig lambda chain V-VI region NIG-48 Ig heavy chain V-III region DOB IGHV(1-?) Ig lambda chain V-IV region Bau clusteredIgG-Ag:FCGRsIGHG1 Ig kappa chain V-I region EU IGLV2-11(1-?) Ig lambda chain V region 4A Ig kappa chain V-II region GM607 p-Y160,Y171-CD3G IGLV10-54(1-?) IGLV1-36(1-?) Ig kappa chain V-III region NG9 Src-kinasesIGLV3-12(1-?) Ig lambda chain V-I region NEW IGLV11-55(1-?) Ig kappa chain V-III region VG Ig lambda chain V-VI region SUT ACTG1 IGLV8-61(1-?) Ig lambda chain V-IV region Hil Ig kappa chain V-III region SIE ADP NCKAP1L Ig lambda chain V region 4A Ig kappa chain V-II region FR Ig kappa chain V-III region Ti Ig lambda chain V-II region TRO IGLV1-44(1-?) IGLV3-27(1-?) WIPF3 ACTR3 Ig kappa chain V-III region WOL Ig kappa chain V-I region Hau p-6Y-CD247-1 IGLV2-23(1-?) ARPC4 Ig heavy chain V-III region LAY Ig kappa chain V-III region VH Ig lambda chain V-II region TOG WIPF1 Ig lambda chain V-IV region Kern Ig kappa chain V-II region RPMI 6410 Ig kappa chain V-I region HK101 Ig heavy chain V-III region HIL Ig lambda chain V-VI region EB4 Ig lambda chain V-V region DEL Ig lambda chain V-VI region NIG-48 Ig kappa chain V-II region FR Ig heavy chain V-III region LAY IGLV3-22(1-?) Ig lambda chain V-VI region WLT Ig heavy chain V-III region ZAP Ig kappa chain V-III region NG9 IGLC2 Ig heavy chain V-II region OU Ig lambda chain V-VI region EB4 MYO10 IGLV3-12(1-?) p-Y291-WAS Ig heavy chain V-I region ND PAK1 Ig heavy chain V-III region BUT Antigen Ig kappa chain V-IV region Len Ig lambda chain V-I region NIG-64 Ig kappa chain V-I region Walker ARPC1A Ig lambda chain V-I region BL2 p-6Y-CD247-1 Ig kappa chain V-III region WOL Ig kappa chain V-I region WAT RAC1 IGLV2-18(1-?) IGHG2 Ig lambda chain V-I region EPS IGLC6 Ig kappa chain V-III region WOL IGHG1 Ig kappa chain V-IV region STH PI(3,4,5)P3 Ig kappa chain V-I region CAR ATPIg lambda chain V-I region EPS Ig kappa chain V-I region Daudi IGHG4 BRK1 Ig heavy chain V-I region HG3 Ig heavy chain V-II region HE ADPIGHG2 Ig lambda chain V-VI region WLT Ig lambda chain V-IV region MOL Ig heavy chain V-II region COR IGLV5-37(1-?) Ig kappa chain V-I region EU Ig kappa chain V-II region RPMI 6410 IGLV1-40(1-?) Ig kappa chain V-III region HAH Ig heavy chain V-II region OU Ig lambda chain V-I region EPS Ig kappa chain V-I region WEA LYN Ig lambda chain V-IV region MOL Ig heavy chain V-III region WEA Ig heavy chain V-II region OU Ig heavy chain V-III region WAS Ig kappa chain V-II region FR F-actinCDC42 Ig kappa chain V-I region BAN IGHG3 IGLV3-25(1-?) Ig lambda chain V-II region VIL Ig lambda chain V-VI region WLT IGLV3-16(1-?) ARPC5 IgH heavy chain V-III region VH26 precursor IGLV3-12(1-?) Ig kappa chain V-I region Bi IGKVA18(21-?) Ig lambda chain V-I region VOR Ig kappa chain V-I region Hau Ig lambda chain V-I region EPS Ig kappa chain V-III region VH Ig heavy chain V-III region CAM p-T508-LIMK1 IGKV1-5(23-?) Ig heavy chain V-II region MCE IGKVA18(21-?) Ig kappa chain V-I region EU RAC1 Ig lambda chain V-I region BL2 Ig heavy chain V-III region TUR Ig kappa chain V-I region Daudi Ig kappa chain V-II region RPMI 6410 Ig lambda chain V-I region NEWM Ig kappa chain V-IV region JI Ig kappa chain V-III region B6 Ig kappa chain V-I region OU Ig heavy chain V-III region POM Ig heavy chain V-II region HE IGLV2-23(1-?) p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3IGLC2 SYKIg kappa chain V-I region Walker Ig kappa chain V-III region WOL F-actin Ig kappa chain V-III region Ti ARPC2 IGLV5-45(1-?) Ig heavy chain V-III region ZAP IGLV3-27(1-?) Ig lambda chain V-IV region Hil Ig lambda chain V-V region DEL IGLV4-3(1-?) ACTR2 Ig heavy chain V-III region TRO p-6Y-CD247-1 Ig kappa chain V-II region MIL Ig kappa chain V-I region WEA Ig kappa chain V-I region Walker Ig heavy chain V-III region WEA Ig lambda chain V-IV region X PI(4,5)P2Ig lambda chain V-II region NEI Ig heavy chain V-I region ND Ig lambda chain V-I region NEWM IGLC7 IGLV2-23(1-?) Ig heavy chain V-I region HG3 IGHG3 PIK3R1 Ig lambda chain V-I region NEW Ig kappa chain V-I region Walker Ig lambda chain V-II region BO HSP90AA1 Ig kappa chain V-IV region B17 RAC1 Ig kappa chain V-II region TEW CFL1ARPC2 Ig heavy chain V-II region OU Ig lambda chain V-III region SH Ig kappa chain V-I region AU p-Y150-WASF2 H2OIg kappa chain V-I region EU WIPF1 Ig heavy chain V-III region WEA Ig heavy chain V-II region COR Ig heavy chain V-I region SIE Ig lambda chain V-II region MGC Ig heavy chain V-II region NEWM Ig lambda chain V-II region TRO FCGR1A IGLV1-44(1-?) Ig lambda chain V-I region MEM p-6Y-CD247-1 p-Y151-WASF1 p-Y288,Y304-FCGR2A Ig lambda chain V-II region NEI ARPC3 IGLC2 IGKC CDC42 IGLV4-60(1-?) IgH heavy chain V-III region VH26 precursor Ig heavy chain V-III region TUR GRB2-1 Ig kappa chain V-I region Ni Ig lambda chain V-II region TOG Ig heavy chain V-III region POM Ig lambda chain V-I region HA IGLV2-33(1-?) Ig lambda chain V-VI region SUT IGLV8-61(1-?) IGHG4 Ig heavy chain V-II region COR Ig kappa chain V-III region VG PhosphatidatephosphataseITPR2 IGLV2-18(1-?) p-5S-ABI1 Ig kappa chain V-IV region STH Ig heavy chain V-III region WEA Ig lambda chain V-II region VIL IGLV2-33(1-?) WIPF2 IgH heavy chain V-III region VH26 precursor IGLV7-46(1-?) Ig kappa chain V-III region IARC/BL41 Ig kappa chain V-I region Rei Ig kappa chain V-I region Gal IGLV4-3(1-?) p-4Y-PLCG1Ig kappa chain V-III region SIE IGLV7-43(1-?) Ig kappa chain V-IV region B17 ARPC1B GTP Ig lambda chain V-I region NEWM PI(3,4,5)P3 Ig lambda chain V-I region NEWM Ig kappa chain V-IV region B17 FCGR2A p-5S-ABI1 Ig kappa chain V-I region Daudi GRB2-1 Ig kappa chain V-I region AG Ig heavy chain V-III region NIE Ig kappa chain V-II region Cum Antigen p-T507,S645,S664-PRKCD(1-676) Ig lambda chain V-II region NIG-84 Ig heavy chain V-III region KOL Ig heavy chain V-III region TRO ABI2 Ig kappa chain V-II region Cum Ig kappa chain V-III region VG clusteredIgG-Ag:p-FCGRs:p-6Y-SYK:p-VAVIGLC2 Ig kappa chain V-I region Scw Ig kappa chain V-I region WEA FCGR3A Ig kappa chain V-III region IARC/BL41 Ig heavy chain V-I region HG3 WIPF1 IGLV3-27(1-?) Ig heavy chain V-I region ND Ig lambda chain V-I region BL2 Ig kappa chain V-III region HIC Ig kappa chain V-I region BAN Ig kappa chain V-I region WEA Ig kappa chain V-I region Hau ELMO2 Ig kappa chain V-IV region Len Ig kappa chain V-I region WAT p-Y256-WASL IGKV4-1(21-?) Ig lambda chain V-I region BL2 Ig lambda chain V-VI region WLT CYFIP1 Ig lambda chain V-I region BL2 IGLV3-22(1-?) p-Y160,Y171-CD3G ATPVAV2 Ig kappa chain V-I region Wes ACTG1 IGLV1-44(1-?) IGLC2 Ig kappa chain V-III region HAH Ig lambda chain V-I region HA Ig lambda chain V-IV region MOL IGHG4 IGLV5-37(1-?) CRK Ig heavy chain V-III region JON CD247-1 IGHV(1-?) BAIAP2 Ig heavy chain V-II region ARH-77 Ig lambda chain V-IV region X IGLV3-12(1-?) Ig lambda chain V-VI region SUT p-Y174-VAV1 Ig kappa chain V-I region Ni WIPF1 PAp-5S-ABI1 Ig heavy chain V-II region WAH Ig heavy chain V-III region TEI Ig heavy chain V-III region BUR Ig heavy chain V-III region BUR Ig heavy chain V-III region BUT Ig heavy chain V-I region WOL GTP Ig kappa chain V-I region Kue Ig kappa chain V-I region WEA VAV1 Ig lambda chain V-II region NIG-58 Ig kappa chain V-II region FR IGLV1-40(1-?) Ig kappa chain V-I region Ka p-Y151-WASF3 Ig heavy chain V-II region SESS WIPF1 Ig kappa chain V-I region Hau IGLV1-36(1-?) Ig kappa chain V-I region WAT Ig heavy chain V-III region KOL Ig kappa chain V-II region RPMI 6410 Ig kappa chain V-III region WOL IGLV4-60(1-?) Ig kappa chain V-I region Lay Ig kappa chain V-I region EU Ig heavy chain V-III region DOB Ig kappa chain V-I region CAR IGLC1 Ig lambda chain V-IV region Kern Ig heavy chain V-I region HG3 IGLV5-37(1-?) PRKCD IGLC6 Ig kappa chain V-III region VH Ig kappa chain V-I region Rei Ig kappa chain V-I region AG Ig kappa chain V-I region DEE Ig kappa chain V-I region WAT ABI1 Ig lambda chain V-I region VOR Ig kappa chain V-I region Ka Antigen Ig heavy chain V-I region WOL Ig kappa chain V-I region Lay Ig kappa chain V-I region Roy RAC1 Ig heavy chain V-I region SIE Ig kappa chain V-II region GM607 IGLC6 Ig lambda chain V-II region TRO Ig kappa chain V-II region GM607 Ig lambda chain V-I region NEWM Ig heavy chain V-I region Mot Ig kappa chain V-III region B6 Ig heavy chain V-III region HIL Ig lambda chain V-II region MGC Ig heavy chain V-I region EU IGLV3-12(1-?) Ig kappa chain V-I region EU Ig heavy chain V-III region BUT RAC1 Ig heavy chain V-I region SIE GTP Ig heavy chain V-III region NIE Ig lambda chain V-II region MGC CYFIP1 Ig kappa chain V-I region DEE Ig heavy chain V-I region ND Ig kappa chain V-II region Cum Ig heavy chain V-III region TEI Ig kappa chain V-II region FR IGHG3 Ig lambda chain V-I region NEW CD247-1 Ig heavy chain V-I region ND Ig kappa chain V-I region Wes Ig heavy chain V-III region WEA Ig lambda chain V-I region MEM Ig kappa chain V-III region NG9 PI(3,4,5)P3 p-Y150-WASF2 Ig heavy chain V-II region OU ITPR2 Ig kappa chain V-I region Mev Ig kappa chain V-II region Cum IGHV7-81(1-?) PI(4,5)P2 CDC42 Ig lambda chain V-V region DEL Ig lambda chain V-I region WAH IGLV3-22(1-?) IGLV10-54(1-?) p-Y160,Y171-CD3G Ig heavy chain V-III region WAS Ig kappa chain V region EV15 IgG-Ag:FCGRIIIA:CD3G/CD3Z dimersIGHG3 Ig lambda chain V-IV region Bau Ig lambda chain V-II region MGC Ig kappa chain V-III region POM p-6Y-SYK p-Y151-WASF1 IGLV3-12(1-?) Ig heavy chain V-III region TIL ARPC4 p-Y150-WASF2 PI3KIg heavy chain V-II region ARH-77 Ig lambda chain V-I region BL2 Ig lambda chain V-IV region Kern Ig heavy chain V-II region MCE Ig kappa chain V-I region OU IGLV7-46(1-?) Ig heavy chain V-III region ZAP Ig kappa chain V-I region Mev Ig heavy chain V-II region NEWM GTP IGLC7 IGKVA18(21-?) FCGR1A IGLC3 IGHG3 IGLV11-55(1-?) Ig lambda chain V-IV region MOL Ig kappa chain V-I region Scw Ig kappa chain V-I region Gal IGLV4-3(1-?) Ig kappa chain V-I region Gal ATPIGHG3 Ig kappa chain V-II region GM607 IGLV1-44(1-?) Ig kappa chain V-I region Ka Ig lambda chain V-II region BOH Ig lambda chain V-II region NIG-84 Ig kappa chain V-I region EU Ig lambda chain V-IV region X ACTB(1-375) p-Y151-WASF1 Ig kappa chain V-III region HAH Ig heavy chain V-III region TIL Actin:ADPIg kappa chain V-I region Kue Ig heavy chain V-I region SIE F-actin IGKV1-5(23-?) IGLC6 Ig lambda chain V-II region TOG Ig lambda chain V-II region TOG IGLV7-46(1-?) IGHV7-81(1-?) IGKVA18(21-?) PCIGHV(1-?) IGLV1-36(1-?) Ig kappa chain V-I region Ni Ig kappa chain V-I region Bi Ig kappa chain V-I region Lay Ig lambda chain V-VI region WLT Ig kappa chain V-I region HK101 Ig lambda chain V-I region WAH Ig heavy chain V-III region TRO p-Y150-WASF2 Ig lambda chain V-II region BOH Ig heavy chain V-III region WAS Ig kappa chain V-III region HIC IGLV2-33(1-?) Ig lambda chain V-IV region X RAC1 Ig heavy chain V-III region BUR Ig kappa chain V-I region Mev Ig lambda chain V-VI region WLT Ig heavy chain V-III region WEA Ig kappa chain V-I region Walker ARPC2 Ig heavy chain V-III region TRO IGKC ARAIGHG2 Ig heavy chain V-II region DAW NCKAP1L ITPR3 IGLV5-45(1-?) Ig heavy chain V-III region TRO Ig lambda chain V-I region NEW Ig lambda chain V-II region NIG-58 Ig kappa chain V-I region Scw IgH heavy chain V-III region VH26 precursor IGLV2-23(1-?) Ig heavy chain V-III region WAS ARP2/3 complex (ATPbound)Ig lambda chain V-VI region EB4 Ig kappa chain V-III region VH GRB2-1 Ig heavy chain V-II region COR IGLC6 ARPC4 Ig heavy chain V-III region KOL Ig kappa chain V-I region Bi Ig kappa chain V-IV region JI Ig lambda chain V-IV region Hil NCKIPSD IGLV4-3(1-?) Ig lambda chain V-I region NEW p-Y151-WASF1 clusteredIgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCGPI(4,5)P2 IGLC7 Ig heavy chain V-III region ZAP Ig kappa chain V-IV region B17 IGKVA18(21-?) IGLV4-3(1-?) Ig heavy chain V-I region EU ATP Ig lambda chain V-VI region AR Ig kappa chain V-I region Ka Ig heavy chain V-II region ARH-77 Ig heavy chain V-I region WOL Ig kappa chain V-II region GM607 p-6Y-SYK Ig kappa chain V-I region DEE Ig kappa chain V-III region HIC IGLC3 Ig lambda chain V-II region NIG-58 IGKV1-5(23-?) Ig heavy chain V-III region ZAP CYFIP1 IGHG3 IGLV4-60(1-?) IGLC7 IGLV1-44(1-?) IGLC2 IGLV1-40(1-?) ITPR2 HCK Ig kappa chain V-I region WEA IGHG4 Ig kappa chain V-I region Mev p-Y151,S,T-WASF1 Ig kappa chain V-III region Ti Ig kappa chain V-I region Lay IGLV4-69(1-?) Ig lambda chain V-I region HA Ig heavy chain V-III region BRO Ig heavy chain V-III region KOL IGLV2-11(1-?) IGLV(23-?) Ig kappa chain V-I region AU Ig heavy chain V-III region GAL Ig kappa chain V-I region OU Ig lambda chain V-II region VIL IGLV3-12(1-?) IGLV(23-?) Ig kappa chain V-III region NG9 Ig kappa chain V-III region POM IGKVA18(21-?) Ig lambda chain V-VI region AR Ig kappa chain V-III region NG9 IGKVA18(21-?) Ig kappa chain V-I region Scw Ig kappa chain V-III region HIC Ig heavy chain V-III region BUR IGHV(1-?) Ig heavy chain V-III region TEI Ig heavy chain V-III region TIL PLCG2 Ig kappa chain V-II region MIL IGLV5-37(1-?) Ig kappa chain V-I region DEE Ig lambda chain V-I region VOR Ig lambda chain V-II region VIL Ig kappa chain V-I region Bi Ig lambda chain V-III region SH IGLV8-61(1-?) Ig heavy chain V-III region BUT Ig kappa chain V-III region NG9 Ig kappa chain V-I region Walker IGLV5-37(1-?) Ig lambda chain V-VII region MOT Ig kappa chain V-I region AG Ig heavy chain V-II region HE Ig kappa chain V-II region GM607 Ig heavy chain V-III region GA Ig heavy chain V-II region SESS Ig lambda chain V-III region LOI ACTR2 IGLC1 IGLC3 Ig kappa chain V-III region B6 Ig heavy chain V-II region ARH-77 Ig kappa chain V-III region POM IGLC2 IGLV5-45(1-?) IGLV4-3(1-?) CRK Ig heavy chain V-III region NIE Ig kappa chain V-I region BAN IGKV4-1(21-?) Ig heavy chain V-I region ND ABI1 Ig kappa chain V-I region Gal IGLC1 Ig kappa chain V-I region OU Ig lambda chain V-V region DEL Ig kappa chain V-IV region STH IGLV4-60(1-?) Ig heavy chain V-III region LAY IGKVA18(21-?) Ig kappa chain V-II region MIL Ig lambda chain V-VI region EB4 Ig lambda chain V-VI region NIG-48 IGLC6 BRK1 IGLV3-16(1-?) Ig heavy chain V-II region HE Ig lambda chain V-I region NIG-64 IGLV7-43(1-?) Ig lambda chain V-VI region AR IGLV7-46(1-?) IGLV7-46(1-?) Ig lambda chain V-IV region Kern RAC1/CDC42:p-S144,T423-PAKARPC4 Ig lambda chain V-II region TOG NCKIPSD IGLV(23-?) p-5S-ABI1 IGLV4-60(1-?) Ig heavy chain V-III region POM Ig kappa chain V-II region RPMI 6410 FCGR2AIg heavy chain V-III region DOB Activated WAVE2 andWASP/N-WASPIg heavy chain V-I region SIE Ig kappa chain V-I region BAN Ig kappa chain V-I region Kue Ig kappa chain V-III region CLL Ig lambda chain V-IV region Kern Ig kappa chain V-I region BAN Ig kappa chain V-I region Lay Ig heavy chain V-II region DAW Ig heavy chain V-II region COR Ig kappa chain V-I region Gal ACTG1 IGLV1-44(1-?) Ig heavy chain V-III region WEA Ig lambda chain V-IV region Hil Ig kappa chain V-III region HAH Ig heavy chain V-II region MCE ARPC4 Ig kappa chain V-IV region STH p-4S-ABI2 p-Y150,S343,T346-WASF2 Ig kappa chain V-I region WAT IGLV5-37(1-?) IGLV1-44(1-?) IGHV(1-?) Ig kappa chain V-I region HK101 Ig lambda chain V-II region VIL Ig kappa chain V-I region Daudi Ig kappa chain V-I region WAT Ig lambda chain V-II region VIL Ig heavy chain V-II region DAW ACTR3 Ig lambda chain V-I region EPS F-actin Ig heavy chain V-III region GAL BAIAP2 Ig lambda chain V-VI region NIG-48 ATP IGLV1-36(1-?) Ig heavy chain V-III region ZAP IGKVA18(21-?) IGLV4-69(1-?) Ig lambda chain V-IV region MOL Ig heavy chain V-I region Mot CYFIP2 Ig kappa chain V-II region MIL ADPIGLV3-12(1-?) p-Y291-WAS Ig heavy chain V-III region GAL Ig heavy chain V-I region WOL Ig kappa chain V-III region SIE Ig lambda chain V-VI region NIG-48 Ig lambda chain V-I region WAH Ig heavy chain V-III region WAS Ig kappa chain V-I region Roy Ig kappa chain V-I region Gal p-Y173-VAV3 YES1 Ig lambda chain V-I region BL2 Ig kappa chain V-I region Rei WIPF3 p-Y753,Y759,Y1217-PLCG2 IGHG3 IGHG3 Ig kappa chain V-II region MIL Ig kappa chain V-I region WAT Ig kappa chain V-I region CAR Ig kappa chain V-III region NG9 Ig kappa chain V-I region WAT Ig heavy chain V-II region ARH-77 Ig lambda chain V-II region VIL Ig lambda chain V-II region NIG-84 Ig lambda chain V-II region TRO Ig lambda chain V-II region WIN CYFIP2 Ig kappa chain V-I region OU Ig kappa chain V-I region Ni Ig kappa chain V-II region TEW Ig heavy chain V-III region NIE Ig lambda chain V-I region WAH FCGR1A IGHV7-81(1-?) p-4Y-PLCG1 Ig lambda chain V-I region NEWM ADPIg lambda chain V-IV region MOL Ig heavy chain V-II region ARH-77 IGLV1-36(1-?) ARPC5 Ig heavy chain V-III region TIL IGLV11-55(1-?) Ig kappa chain V-I region Ka IGLV5-37(1-?) IGHV(1-?) Ig heavy chain V-III region POM Ig kappa chain V-II region GM607 IgH heavy chain V-III region VH26 precursor ATPACTG1 NCKAP1L Ig heavy chain V-II region OU Ig heavy chain V-II region ARH-77 Ig lambda chain V-IV region Hil p-Y160,Y171-CD3G Ig kappa chain V-I region Wes p-Y288,Y304-FCGR2A Ig lambda chain V-III region SH RAC1 Ig kappa chain V-I region WAT IGLV5-45(1-?) Ig heavy chain V-III region CAM IGLV2-33(1-?) Ig kappa chain V-I region Kue Ig heavy chain V-I region WOL Ig lambda chain V-II region TOG IGLC3 ATPIGHG3 Ig kappa chain V-I region BAN Ig kappa chain V-I region BAN ACTR2 IGLV11-55(1-?) GTP Ig heavy chain V-I region WOL IGLV5-45(1-?) Ig heavy chain V-III region TUR WIPF2 Ig kappa chain V region EV15 IGLV2-11(1-?) IGLV1-36(1-?) Ig heavy chain V-I region WOL Ig kappa chain V-I region Roy Ig lambda chain V-II region TRO Ig kappa chain V-III region HAH VAV3 p-Y288,Y304-FCGR2A Ig heavy chain V-III region TUR Ig lambda chain V-II region NIG-84 WAVE RegulatoryComplexIGLV2-11(1-?) Ig lambda chain V-II region BUR Ig kappa chain V-III region POM Ig heavy chain V-III region HIL Ig heavy chain V-III region HIL Ig lambda chain V-I region MEM IgH heavy chain V-III region VH26 precursor ACTR2 IGLC7 Ig kappa chain V-III region NG9 Ig kappa chain V region EV15 p-Y160,Y171-CD3G IGLV11-55(1-?) Ig heavy chain V-III region POM Ig kappa chain V-III region SIE p-6Y-CD247-1 GTP IGHV(1-?) IGLV(23-?) Ig kappa chain V-III region SIE Ig heavy chain V-III region DOB CDC42 Ig lambda chain V-II region BO Ig kappa chain V-III region IARC/BL41 p-Y151-WASF3 Ig heavy chain V-III region GAL Ig heavy chain V-III region HIL IGLV3-25(1-?) GDP Ig heavy chain V-III region TRO Ig lambda chain V-V region DEL IGLV3-16(1-?) Ig kappa chain V-I region Rei Ig lambda chain V-I region EPS IGLV4-69(1-?) Ig kappa chain V-III region HIC Ig kappa chain V-II region FR IGLV3-22(1-?) IGLV10-54(1-?) Ig kappa chain V-I region CAR PRKCE Ig lambda chain V-IV region X Ig kappa chain V-I region WEA Ig lambda chain V-V region DEL Ig kappa chain V-I region Kue Ig kappa chain V-III region NG9 Ig lambda chain V-II region TOG IGLV8-61(1-?) Ig heavy chain V-I region HG3 Ig heavy chain V-III region HIL Ig kappa chain V-III region HIC PPAPDC1A Ig heavy chain V-III region TUR IGLC3 Ig heavy chain V-III region GAL IGKC IGHG3 Antigen IGLC1 Ig lambda chain V-I region WAH Ig lambda chain V-IV region Kern Ig kappa chain V-I region Roy HSP90AB1 Ig lambda chain V-VI region EB4 Ig heavy chain V-I region SIE Ig kappa chain V-I region Bi Ig kappa chain V-I region Ni Ig heavy chain V-III region TEI p-Y150-WASF2 RAC1 IGLV10-54(1-?) NCKAP1L IGLC7 Ig kappa chain V-I region AU H2OWASP/N-WASPIg heavy chain V-III region LAY IGLC1 IGHG4 Ig kappa chain V-I region Wes Ig lambda chain V-I region HA Ig kappa chain V-II region TEW NCKAP1 Ig lambda chain V-IV region Bau Ig lambda chain V-IV region MOL 2-LysophosphatidylcholineNCKAP1L IGLV1-44(1-?) Ig lambda chain V-I region VOR ABI1 Ig lambda chain V-I region NEW Ig heavy chain V-III region CAM Ig heavy chain V-III region LAY Ig kappa chain V-IV region STH IgH heavy chain V-III region VH26 precursor Ig kappa chain V-I region Roy CYFIP2 Ig kappa chain V-II region TEW Ig kappa chain V-I region Ni Ig lambda chain V-II region NIG-58 Ig kappa chain V-I region Rei ACTB(1-375) Ig heavy chain V-III region GAL CYFIP2 Ig lambda chain V-I region EPS Ig heavy chain V-I region Mot FCGR1A BRK1 IGLV1-40(1-?) PIK3CA Ig lambda chain V-VI region SUT Ig kappa chain V-I region DEE IGLV2-23(1-?) Ig lambda chain V-III region LOI IGKV1-5(23-?) Ig kappa chain V-II region TEW Ig lambda chain V-II region BUR Ig kappa chain V-I region Gal ARPC1A p-Y288,Y304-FCGR2A PIK3R2 IGKVA18(21-?) Ig lambda chain V-VI region AR Ig heavy chain V-III region GAL IGLV3-27(1-?) IGKV1-5(23-?) FCGRIIIA:CD3G/CD3ZdimersIg heavy chain V-II region SESS IGLV3-16(1-?) Ig kappa chain V-I region Hau IGLV4-3(1-?) GTP IGLV3-27(1-?) Ig kappa chain V region EV15 Ig lambda chain V-II region MGC IGHG2 Ig lambda chain V-I region BL2 IGKVA18(21-?) Antigen Ig kappa chain V-III region HAH Ig lambda chain V-I region VOR Ig lambda chain V-I region NEW Ig kappa chain V-I region WEA Ig lambda chain V-II region NIG-84 Ig kappa chain V-I region AG Ig heavy chain V-I region WOL p-Y150-WASF2 Ig kappa chain V-I region Roy ATPIg lambda chain V-I region VOR p-S3-CFL1 Ig kappa chain V-I region Mev Ig heavy chain V-III region JON IGLV3-16(1-?) Ig heavy chain V-III region TIL IGLV2-33(1-?) Ig heavy chain V-II region MCE Ig lambda chain V-II region TRO Ig kappa chain V-I region DEE GTP NCKIPSD Ig lambda chain V-II region BO IGLV4-69(1-?) IGLV4-69(1-?) Ig heavy chain V-III region HIL Ig lambda chain V-VI region NIG-48 Ig kappa chain V-I region CAR Ig kappa chain V-IV region JI Ig heavy chain V-III region KOL Ig heavy chain V-III region TUR IGLV2-18(1-?) IGHG2 Ig kappa chain V-I region Wes Ig kappa chain V-IV region JI Ig kappa chain V-I region Daudi ATP IGLV5-45(1-?) RAC1 Ig heavy chain V-III region BRO GTP Ig lambda chain V-II region BO VAV2 Ig lambda chain V-II region BUR p-Y291-WAS Ig lambda chain V-III region SH Ig lambda chain V-I region NEW Ig lambda chain V-II region TOG IGLC7 Ig kappa chain V-I region Scw Ig kappa chain V-IV region JI Ig kappa chain V-I region Rei Ig heavy chain V-III region WAS IGLV7-46(1-?) CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteinsIGHG3 Ig heavy chain V-III region GAL Ig lambda chain V-II region VIL Ig heavy chain V-I region SIE IGLV7-43(1-?) Ig heavy chain V-II region DAW Ig kappa chain V region EV15 p-Y151-WASF1 ABI2 p-Y151,S,T-WASF1 p-6Y-CD247-1 Ig lambda chain V-I region HA IGLV3-22(1-?) p-Y151-WASF3 IGLV4-69(1-?) IGHG3 IGLV5-37(1-?) ARPC5 p-Y151-WASF3 Ig lambda chain V-IV region Bau Ig kappa chain V-I region Walker IGLV3-27(1-?) Ig kappa chain V-I region HK101 IGLV3-27(1-?) p-Y288,Y304-FCGR2A IGLV1-44(1-?) Ig heavy chain V-I region EU Ig heavy chain V-III region TUR Ig kappa chain V-III region NG9 Ig heavy chain V-III region WAS WASF3 Ig kappa chain V-I region WAT IGLC1 Ig heavy chain V-II region MCE Ig heavy chain V-III region LAY Ig heavy chain V-II region HE Ig lambda chain V-II region NEI ABI1 IGHV7-81(1-?) Ig lambda chain V-V region DEL Ig heavy chain V-III region BUR IGLV3-25(1-?) Ig lambda chain V-VII region MOT Ig lambda chain V-I region NIG-64 Ig heavy chain V-III region TRO Ig heavy chain V-III region LAY Ig kappa chain V-I region Roy Ig kappa chain V-I region WAT p-Y151,S,T-WASF1 IGKV1-5(23-?) IGHV7-81(1-?) Ig kappa chain V-I region Ni Ig kappa chain V-III region SIE IGLV1-40(1-?) Ig lambda chain V-II region BUR Ig heavy chain V-I region ND Ig kappa chain V-III region B6 Ig kappa chain V-I region WAT Ig lambda chain V-I region NIG-64 PAK1Ig lambda chain V-II region WIN Ig heavy chain V-II region ARH-77 IGLV4-3(1-?) Ig kappa chain V region EV15 Ig lambda chain V-II region NIG-84 ARPC2 clusteredIgG-Ag:p-FCGRs:SYKAntigen p-T202,Y204-MAPK3 Antigen Ig kappa chain V-I region Daudi IgH heavy chain V-III region VH26 precursor ARPC1A Ig heavy chain V-I region ND IGLV8-61(1-?) Ig kappa chain V-III region WOL Ig heavy chain V-III region KOL ABI2 Ig heavy chain V-III region BUR PI3K:p-6Y-SYKIg kappa chain V-III region SIE IGLV1-36(1-?) Ig lambda chain V-II region NEI Ig kappa chain V-IV region B17 Ig heavy chain V-III region NIE Ig lambda chain V-IV region Bau Ig lambda chain V-IV region Bau FCGR1A Ig lambda chain V-IV region Kern Ig lambda chain V-II region BUR Ig kappa chain V-IV region Len Ig lambda chain V-V region DEL PiIg lambda chain V-IV region MOL IGLV1-44(1-?) Ig lambda chain V-III region LOI Ig heavy chain V-III region WEA IGLV11-55(1-?) Ig heavy chain V-III region BRO Ig kappa chain V-I region AG Ig kappa chain V-II region Cum Ig kappa chain V-III region CLL Ig lambda chain V-IV region X p-Y151,S,T-WASF3 Ig heavy chain V-III region BUR FCGR3A Ig kappa chain V-IV region STH Ig kappa chain V-I region Rei Ig heavy chain V-II region COR ARPC1A FCGR1A BRK1 Ig kappa chain V-I region Scw IGLC6 Ig lambda chain V-II region BO Ig lambda chain V-II region BO Ig lambda chain V-I region WAH Ig lambda chain V-II region MGC Ig kappa chain V-I region WAT Ig heavy chain V-I region EU Ig lambda chain V-III region SH Ig lambda chain V-II region NIG-58 Ig kappa chain V-I region Gal Ig heavy chain V-III region GAL IGLV2-11(1-?) p-Y150,S343,T346-WASF2 Ig heavy chain V-III region TEI Ig kappa chain V-I region Scw Ig heavy chain V-II region HE Ig heavy chain V-III region DOB Ig kappa chain V-I region Scw Ig heavy chain V-I region EU WIPF2 Ig heavy chain V-III region TEI IGHV7-81(1-?) IGHG4 Ig kappa chain V-I region Wes Ig lambda chain V-I region BL2 Ig kappa chain V-III region VG Ig kappa chain V-III region GOL Ig lambda chain V-I region HA Ig kappa chain V-I region Daudi Ig kappa chain V-III region GOL p-Y150,S343,T346-WASF2 Ig kappa chain V-III region IARC/BL41 PI(4,5)P2 Ig lambda chain V-VI region AR Ig lambda chain V-II region NEI IGLV7-43(1-?) Ig lambda chain V-II region VIL IGLV1-36(1-?) Ig kappa chain V-I region Walker Ig heavy chain V-III region BRO IGLV7-46(1-?) Ig heavy chain V-II region OU PI(4,5)P2Ig kappa chain V-III region IARC/BL41 FCGR3A AHCYL1 Ig kappa chain V-III region WOL Ig lambda chain V-VII region MOT IGLV3-25(1-?) Ig kappa chain V-I region DEE IGLV8-61(1-?) IGLV3-16(1-?) Ig heavy chain V-I region WOL ABI1 Ig heavy chain V-III region TUR PI(3,4,5)P3 SH3 domain proteinsIg kappa chain V-III region CLL IGHG2 Ig lambda chain V-II region VIL Ig kappa chain V-III region POM ARPC5 Ig heavy chain V-II region OU Ig kappa chain V-III region HAH IGLV5-45(1-?) Ig lambda chain V-IV region X CYFIP1 H2OAHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramerp-4S-ABI2 Ig kappa chain V-III region GOL Ig kappa chain V-I region Bi Ig kappa chain V-I region Gal CYFIP1 Ig kappa chain V-III region HAH Ig lambda chain V-II region WIN Antigen-antibodycomplexIGLV3-22(1-?) IGLV1-40(1-?) CDC42 ARPC1B Ig heavy chain V-III region GA IGLC1 Ig lambda chain V-IV region Kern Ig kappa chain V-I region AU ACTR2 WIPF1 MYH2 IGKC p-T185,Y187-MAPK1 ADPIGLV3-16(1-?) IGKV4-1(21-?) IGLV1-44(1-?) Ig kappa chain V-I region Daudi Ig heavy chain V-III region POM IGLV4-3(1-?) ACTG1 Ig lambda chain V-II region NEI Ig kappa chain V-I region Ni Ig heavy chain V-II region NEWM Ig lambda chain V-I region BL2 BAIAP2Ig lambda chain V-I region NEWM Ig kappa chain V-I region Bi IGLV1-44(1-?) Ig lambda chain V-II region TOG Ig kappa chain V-I region Hau Ig lambda chain V-I region NEWM IGLV2-23(1-?) IGHV(1-?) Ig kappa chain V-III region B6 Ig heavy chain V-II region MCE IGLV10-54(1-?) Ig heavy chain V-I region Mot Ig kappa chain V region EV15 ATPIg heavy chain V-I region EU Ig heavy chain V-III region GAL IGLV5-37(1-?) Ig lambda chain V-II region TRO Ig heavy chain V-III region TIL Ig lambda chain V-VI region EB4 Ig lambda chain V-III region SH ABI2 Ig lambda chain V-IV region Hil Ig lambda chain V-II region TOG Ig kappa chain V-III region GOL Ig heavy chain V-I region EU Ig lambda chain V-I region VOR Ig kappa chain V-II region FR IGHG4 Ig heavy chain V-II region WAH IgH heavy chain V-III region VH26 precursor IGHG1 Ig lambda chain V-I region NEW Ig heavy chain V-III region BRO Ig kappa chain V-I region Hau Ig kappa chain V-I region Hau CYFIP2 IGLC1 IGLC3 Ig kappa chain V-IV region Len Ig heavy chain V-III region CAM Ig kappa chain V-I region Lay Ig heavy chain V-III region TIL Ig kappa chain V-I region Bi Ig kappa chain V-III region NG9 IGHV7-81(1-?) PI(3,4,5)P3 Ig lambda chain V-II region NEI Ig kappa chain V-I region EU Ig kappa chain V-II region TEW RAC1/CDC42:PAK dimerIg kappa chain V-III region GOL IGHG2 Ig lambda chain V-III region SH Ig kappa chain V-III region SIE Ig lambda chain V-I region VOR Ig kappa chain V-I region BAN PLA2G6Ig kappa chain V-III region GOL Ig kappa chain V-III region SIE Ig lambda chain V-I region HA PAK1 RAC1:GTPIg lambda chain V-VI region AR IGLV4-3(1-?) PLD2 Ig kappa chain V-II region Cum ACTR2 Ig lambda chain V-IV region MOL NCKAP1L IGLV11-55(1-?) Ig kappa chain V-I region Scw Ig heavy chain V-I region WOL MYO10 Ig kappa chain V-IV region B17 MYO5A Ig kappa chain V-II region MIL Ig heavy chain V-III region POM Ig heavy chain V-II region HE Ig heavy chain V-I region EU IGLC1 GTP MYO1C Ig lambda chain V-VI region EB4 Ig kappa chain V-II region RPMI 6410 N-WASP Ig lambda chain V-I region WAH Ig heavy chain V-III region TEI IGLC7 Ig heavy chain V-III region TEI Ig kappa chain V-I region Hau IGLV7-43(1-?) ARPC1B Ig lambda chain V-II region TRO Ig kappa chain V-III region HAH I(1,4,5)P3Ig lambda chain V-VI region NIG-48 Ig heavy chain V-III region TIL Ig heavy chain V-II region NEWM Ig heavy chain V-I region EU GDP IGLV3-22(1-?) NCK1 Ig lambda chain V-V region DEL FCGR3A Ig heavy chain V-III region POM IGLC3 Ig lambda chain V-IV region Kern Ig kappa chain V-I region CAR ARPC3 Ig kappa chain V-I region Ni Ig kappa chain V-IV region STH Ig kappa chain V-III region VG Ig heavy chain V-II region MCE G-actinIg kappa chain V-II region MIL Ig heavy chain V-III region ZAP Ig lambda chain V-II region NIG-84 IGLV3-12(1-?) Ig lambda chain V-I region HA Ig kappa chain V-I region AU Ig kappa chain V-III region WOL IGLV3-16(1-?) Ig kappa chain V-III region VH IGLV1-40(1-?) Ig kappa chain V-I region Wes Ig kappa chain V-I region Walker Ig kappa chain V-I region Scw IGHG4 Ig lambda chain V-II region NIG-58 Ig lambda chain V-II region MGC Ig kappa chain V-I region Daudi Ig lambda chain V-I region MEM Ig lambda chain V region 4A Ig kappa chain V-III region WOL Ig heavy chain V-III region NIE Ig heavy chain V-III region HIL N-WASP Ig kappa chain V-II region MIL Ig kappa chain V-I region AU IGLV3-16(1-?) p-Y256-WASL IGLC2 ARPC3 Ig heavy chain V-III region BUT FCGR3A IGLC3 Ig heavy chain V-III region BUR ARPC1B Ig kappa chain V-III region SIE Ig lambda chain V-IV region Bau Ig lambda chain V-I region EPS Ig heavy chain V-II region COR Ig kappa chain V-I region WEA PPAPDC1B Ig lambda chain V-II region NIG-84 Ig lambda chain V-III region SH Ig heavy chain V-II region NEWM Ig lambda chain V-I region NEWM Ig lambda chain V-I region NEW Ig heavy chain V-III region ZAP Ig heavy chain V-III region WEA Ig lambda chain V-III region SH ARPC1A Ig kappa chain V-IV region B17 IGLV2-23(1-?) IGLV3-25(1-?) Ig lambda chain V-I region NIG-64 Ig kappa chain V region EV15 Ig lambda chain V-I region WAH Ig kappa chain V-I region WAT Ig lambda chain V-II region BO Ig kappa chain V-I region Ka PI(4,5)P2IGLC1 Ig heavy chain V-III region WEA Ig lambda chain V-VII region MOT Ig kappa chain V-III region B6 ABL1Ig heavy chain V-I region ND ABI2 NCKIPSD Ig heavy chain V-III region POM VAV3 IGKC HSP90AA1,HSP90AB1Ig lambda chain V-II region TRO IGLC7 Ig kappa chain V-IV region STH Ig kappa chain V-I region Mev Ig heavy chain V-III region BUT Ig lambda chain V-II region BOH IGLV3-25(1-?) Ig lambda chain V-I region NEWM Ig heavy chain V-III region CAM IGLV2-18(1-?) Ig kappa chain V-II region MIL Ig kappa chain V-I region Gal IGLV10-54(1-?) p-4S-ABI2 ATPIg lambda chain V-II region NIG-84 Ig kappa chain V-III region CLL PLC gamma1,2IGKV4-1(21-?) Ig heavy chain V-III region JON IGLV1-40(1-?) Ig lambda chain V-I region NIG-64 Ig heavy chain V-II region WAH Ig kappa chain V-III region B6 Ig lambda chain V-II region TRO ADPIg heavy chain V-III region POM Ig lambda chain V-IV region X GRB2-1 Ig kappa chain V-IV region B17 IGLV(23-?) Ig kappa chain V-I region CAR IGLV7-46(1-?) IGLV7-46(1-?) Ig heavy chain V-III region GA IGLV4-69(1-?) IGLV3-25(1-?) Ig kappa chain V-I region WEA PI(3,4,5)P3IGLV5-37(1-?) Ig kappa chain V-I region Walker BRK1 p-S144,T423-PAK1Ig heavy chain V-II region DAW Antigen Ig kappa chain V-III region POM Ig heavy chain V-III region TRO Ig kappa chain V-I region Ka Ig kappa chain V-III region GOL Ig heavy chain V-III region BUT ARPC3 IGLV2-18(1-?) Ig lambda chain V-II region NIG-58 Ig lambda chain V-II region BUR WASF2 p-Y288,Y304-FCGR2A Ig kappa chain V-I region Lay CYFIP2 Ig kappa chain V-I region EU IGLV1-44(1-?) Ig kappa chain V-II region FR IGHG4 Ig kappa chain V-I region DEE ATPIGKV4-1(21-?) Ig kappa chain V-I region Walker Ig heavy chain V-III region BUR ADP IGLV4-60(1-?) IGLV7-43(1-?) Ig heavy chain V-I region SIE Ig kappa chain V-IV region STH IGLV3-16(1-?) Ig heavy chain V-I region Mot IGLV7-46(1-?) Ig heavy chain V-I region HG3 ACTB(1-375) CYFIP1 Ig heavy chain V-I region ND Ig heavy chain V-I region Mot NCK1 Ig kappa chain V-III region B6 Ig heavy chain V-II region HE Ig heavy chain V-III region GAL Antigen Ig lambda chain V-II region BOH Ig lambda chain V-II region WIN IGLV5-45(1-?) Ig heavy chain V-III region GAL ATPIGLV4-60(1-?) Ig kappa chain V-IV region STH IGLV4-60(1-?) Ig heavy chain V-III region GA Ig kappa chain V-I region Scw Ig lambda chain V-I region VOR Ig heavy chain V-III region KOL Ig kappa chain V-II region FR IGLC3 Ig kappa chain V-III region WOL Ig kappa chain V-I region Rei Ig kappa chain V region EV15 Ig kappa chain V-III region IARC/BL41 ABI1 Ig lambda chain V-IV region Hil GTP Ig kappa chain V-III region Ti Ig lambda chain V-III region SH Ig lambda chain V-VI region NIG-48 Ig heavy chain V-I region HG3 Ig kappa chain V-I region Roy IGLV2-11(1-?) ADPIg kappa chain V-I region Kue Ig kappa chain V-III region GOL IGHG4 Ig lambda chain V-I region EPS Ig heavy chain V-III region JON IGLV3-12(1-?) IGLC1 Ig lambda chain V-II region BUR Ig lambda chain V-I region HA ARPC1B PI(3,4,5)P3 IGLV10-54(1-?) Ig kappa chain V-I region Wes FCGR3A IGLV2-18(1-?) Ig kappa chain V-III region IARC/BL41 IGLV4-69(1-?) IGLV1-36(1-?) Ca2+Ig lambda chain V-I region VOR Ig lambda chain V-VI region EB4 Ig heavy chain V-II region MCE NCKAP1 IGLV2-18(1-?) Ig heavy chain V-II region DAW Ig lambda chain V-IV region Kern Ig lambda chain V-I region MEM Ig heavy chain V-III region CAM IGLV4-60(1-?) Ig lambda chain V-V region DEL Ig lambda chain V-VI region AR Ig heavy chain V-III region GAL Ig lambda chain V-II region VIL Ig kappa chain V-I region CAR Ig kappa chain V-I region CAR IGHG4 p-Y288,Y304-FCGR2A Ig heavy chain V-II region DAW IGHV(1-?) Ig heavy chain V-III region GA ELMO1 WIPF2 Ig heavy chain V-III region CAM IGLV3-16(1-?) BAIAP2 Ig lambda chain V-II region BO CDC42 FCGR3A Ig kappa chain V-I region DEE Ig kappa chain V-IV region Len IGLV1-40(1-?) WIPF1 Ig kappa chain V-III region WOL Ig kappa chain V-I region HK101 p-5S-ABI1 p-Y256-WASL PLDIGLV2-33(1-?) IGLC6 Ig heavy chain V-I region WOL Ig kappa chain V-III region B6 IgH heavy chain V-III region VH26 precursor IGLV4-69(1-?) Ig kappa chain V-I region Walker ARPC4 Ig lambda chain V-II region NIG-58 Ig lambda chain V-IV region Hil MYO1C IGKV4-1(21-?) Ig kappa chain V-I region CAR Ig heavy chain V-III region DOB IGLV10-54(1-?) WIPF2 Ig heavy chain V-III region DOB IGLV2-33(1-?) IGKVA18(21-?) CDC42 Ig kappa chain V-I region CAR IGLV3-22(1-?) Ig kappa chain V-I region Hau Ig lambda chain V-III region LOI HSP90AA1 IGLV2-33(1-?) Ig lambda chain V-II region NIG-58 Ig kappa chain V-I region Scw IGLV2-18(1-?) Ig heavy chain V-II region NEWM NCK1 FCGR1A ABI1 Ig heavy chain V-III region GAL GTP GTP Ig heavy chain V-III region BRO IGHG1 Ig heavy chain V-I region SIE Ig heavy chain V-III region GA Ig lambda chain V region 4A Ig heavy chain V-I region Mot Ig heavy chain V-II region OU IGLV4-3(1-?) Ig heavy chain V-III region DOB Ig heavy chain V-II region NEWM Ig kappa chain V-I region AG Ig kappa chain V-IV region STH MYO5A IGLV3-16(1-?) Ig kappa chain V-I region Bi Ig kappa chain V-I region Gal IGLV2-33(1-?) Ig lambda chain V-I region VOR CDC42:GTP:WASP/N-WASPp-Y150,S343,T346-WASF2 BAIAP2 Ig lambda chain V-IV region X Ig heavy chain V-III region DOB IGLV3-27(1-?) Ig heavy chain V-II region WAH Ig kappa chain V-IV region STH p-Y172-VAV2 p-Y151,S,T-WASF3 Ig lambda chain V-II region BOH Ig heavy chain V-II region HE IGLV1-44(1-?) Ig kappa chain V-III region CLL Ig kappa chain V-II region FR Ig kappa chain V-III region HAH Ig kappa chain V-I region DEE Ig kappa chain V-III region POM Ig heavy chain V-I region SIE Ig lambda chain V-I region BL2 Ig heavy chain V-II region ARH-77 Ig heavy chain V-III region BUT Ig lambda chain V region 4A Ig lambda chain V-II region TOG HSP90AB1 Ig lambda chain V-I region VOR Ig heavy chain V-III region TRO Ig lambda chain V-IV region Hil Ig kappa chain V-III region SIE NCKAP1 IGHV(1-?) IGLV2-18(1-?) IGLV10-54(1-?) Ig heavy chain V-III region TEI Ig heavy chain V-III region GA Ig kappa chain V-II region GM607 IGLV3-22(1-?) Ig kappa chain V-I region Roy MYO9B IGLV1-36(1-?) Ig kappa chain V-III region Ti Ig lambda chain V region 4A Ig lambda chain V-II region NIG-58 Ig heavy chain V-II region ARH-77 Ig kappa chain V-IV region B17 Ig kappa chain V-I region Daudi Ig heavy chain V-II region WAH Ig kappa chain V-II region RPMI 6410 Ig lambda chain V-IV region Bau Ig kappa chain V-I region WEA Ig kappa chain V-I region Lay Ig kappa chain V-II region TEW Ig heavy chain V-I region HG3 IGLV2-18(1-?) Ig kappa chain V-I region Ka Ig heavy chain V-III region WEA WAS Ig lambda chain V-II region BO IGLV4-69(1-?) IGLV10-54(1-?) NCKIPSD Ig kappa chain V-I region WEA IGLV5-45(1-?) Ig kappa chain V-III region IARC/BL41 Ig lambda chain V-II region WIN PLD4 Ig kappa chain V-I region EU Ig lambda chain V-II region BOH Ig kappa chain V-I region Daudi Ig heavy chain V-I region HG3 Ig kappa chain V-I region OU CD3G Ig lambda chain V-II region NEI Ig heavy chain V-II region MCE IGHV7-81(1-?) CD3G Ig kappa chain V-II region GM607 Ig kappa chain V region EV15 Ig kappa chain V-II region RPMI 6410 Ig lambda chain V-I region NEWM Ig lambda chain V-I region NIG-64 IGLV5-45(1-?) Ig heavy chain V-III region LAY IGLV2-23(1-?) RAC1:GDPPI(3,4,5)P3 Ig lambda chain V-VI region SUT Ig kappa chain V-III region VH Ig lambda chain V-VI region SUT GTP Ig heavy chain V-III region NIE Ig kappa chain V-I region Bi FCGRIA:CD3GhomodimerIGLC2 Ig heavy chain V-III region NIE Ig kappa chain V-I region Daudi Ig lambda chain V-VI region NIG-48 Ig lambda chain V-II region BUR ACTB(1-375) Ig kappa chain V-I region Wes GTP Ig lambda chain V-I region HA ABI2 Ig lambda chain V-VI region EB4 Ig kappa chain V-I region DEE Ig heavy chain V-I region Mot Ig kappa chain V-I region EU Antigen Ig lambda chain V-IV region Bau Ig kappa chain V-III region B6 Ig heavy chain V-I region ND Ig heavy chain V-II region DAW GDPIGLV11-55(1-?) NCKAP1 IGLV8-61(1-?) Ig kappa chain V-II region FR IGLC7 Ig kappa chain V-I region OU Ig lambda chain V-II region WIN PIK3CA Ig lambda chain V-VI region WLT Ig kappa chain V-II region RPMI 6410 Ig lambda chain V-IV region Bau WIPF3 IGLC6 IGLV3-22(1-?) Ig lambda chain V-VII region MOT RAC1 IGLV1-36(1-?) MYO9B Ig kappa chain V-II region TEW Ig heavy chain V-II region COR Ig heavy chain V-II region NEWM IGLC2 Ig heavy chain V-III region NIE Ig heavy chain V-II region SESS Ig heavy chain V-II region ARH-77 Ig heavy chain V-III region TRO p-Y150,S343,T346-WASF2 Ig heavy chain V-III region POM Ig kappa chain V-II region MIL Ig kappa chain V-III region VG IGLV7-43(1-?) Ig kappa chain V-I region Rei Ig lambda chain V-III region LOI p-Y291-WAS Ig heavy chain V-III region TIL IGHG2 Ig heavy chain V-II region HE Ig lambda chain V-II region WIN Ig kappa chain V-III region VG Ig kappa chain V-I region WAT IGLV2-33(1-?) IGLV7-46(1-?) Ig kappa chain V-I region CAR p-Y288,Y304-FCGR2A Ig heavy chain V-I region HG3 Ig kappa chain V-III region HAH Ig kappa chain V-I region OU Ig kappa chain V-III region Ti p-6Y-CD247-1 Ig lambda chain V-I region NEW Actin filament boundMyosin-XIg kappa chain V-IV region STH PI(4,5)P2 IGLC1 CDC42 DAGsNCKAP1 Ig kappa chain V-III region SIE IGHG2 IGLV5-45(1-?) CDC42 Ig kappa chain V-I region Kue Ig kappa chain V-I region Roy Ig lambda chain V-I region EPS WIPF3 Ig heavy chain V-III region TUR Ig kappa chain V-III region VH Ig kappa chain V-III region CLL Ig lambda chain V-I region NEWM IGLC7 IGLV(23-?) Ig lambda chain V-II region WIN Ig heavy chain V-III region LAY Ig heavy chain V-I region EU Ig lambda chain V-IV region MOL IGLV2-11(1-?) Ig kappa chain V-I region Ni Ig kappa chain V-IV region B17 Ig heavy chain V-III region CAM IGLV(23-?) IGLV2-23(1-?) Ig heavy chain V-III region JON Ig kappa chain V-I region AG Ig lambda chain V-II region TRO CDC42:GDPPIK3R1 p-Y160,Y171-CD3G CD3G Ig kappa chain V-I region Hau WASF2 CDC42:GTP, RAC1:GTPIg kappa chain V region EV15 Ig kappa chain V-I region Bi Ig lambda chain V-VI region AR NCKAP1L ACTR3 Ig lambda chain V region 4A Ig kappa chain V-IV region Len Ig heavy chain V-III region BRO IGHG1 ATP GTP Ig lambda chain V-I region BL2 Ig kappa chain V-III region HAH IGLV2-33(1-?) Ig lambda chain V-IV region Hil Ig lambda chain V-II region WIN IGLV3-25(1-?) p-6Y-CD247-1 Ig lambda chain V-I region MEM PI(3,4)P2Ig heavy chain V-III region CAM Ig lambda chain V-II region BUR ADPIg heavy chain V-II region SESS Ig kappa chain V-I region Kue Ig kappa chain V-I region Lay Ig kappa chain V-I region Lay Ig lambda chain V-IV region Bau Ig kappa chain V-I region AG IGLV1-40(1-?) Ig heavy chain V-II region SESS Ig kappa chain V-I region HK101 IGLV8-61(1-?) Ig lambda chain V-I region HA IGLV3-22(1-?) IGLV5-45(1-?) IGLV1-40(1-?) Ig lambda chain V-II region MGC Ig kappa chain V-I region AU PCp-S144,T423-PAK1 p-4Y-PLCG1 Ig kappa chain V-I region Ni Ig heavy chain V-III region HIL WIPF2 IGLV2-33(1-?) Ig lambda chain V-II region VIL Ig kappa chain V-I region Gal IGLC6 Ig lambda chain V-II region VIL Ig heavy chain V-III region TEI SRC-1 ARPC5 Ig lambda chain V-II region NIG-84 Ig lambda chain V-I region NIG-64 ACTR3 Ig lambda chain V-VI region NIG-48 Ig kappa chain V-I region HK101 Ig kappa chain V-III region POM FAK1 Ig kappa chain V-III region CLL Ig lambda chain V-IV region Hil Ig kappa chain V-I region BAN GTP BRK1 IGLC1 Ig heavy chain V-II region OU Ig heavy chain V-III region JON Ig lambda chain V-VI region AR Ig kappa chain V-I region Lay Ig kappa chain V-I region AU IGLV4-3(1-?) Ig heavy chain V-II region COR Ig lambda chain V-VI region AR Ig heavy chain V-III region TIL Ig heavy chain V-I region EU Ig kappa chain V-II region MIL IGHG1 Ig kappa chain V-I region WEA Ig lambda chain V-I region NEW ABI1 Ig heavy chain V-III region POM Ig heavy chain V-III region WAS Ig heavy chain V-II region SESS Ig kappa chain V-II region GM607 NCK1 IGLV1-40(1-?) Ig heavy chain V-III region LAY Ig heavy chain V-II region HE Ig heavy chain V-III region BUR PLD3 Ig kappa chain V-III region VG Ig lambda chain V-II region NIG-58 Ig heavy chain V-II region SESS Ig kappa chain V-I region EU Ig kappa chain V-I region AU Ig kappa chain V-I region Kue WASF1 Ig kappa chain V-IV region B17 Ig heavy chain V-III region TEI IP3 receptorhomotetramerIg kappa chain V-I region OU Ig lambda chain V-II region MGC Ig heavy chain V-II region COR IGLV2-23(1-?) Antigen Ig lambda chain V-I region VOR LIMK1Ig kappa chain V-II region Cum p-6Y-SYK Ig lambda chain V-VI region WLT IGHG1 NCKIPSD Myosin-ActinfilamentsWASF3 Ig kappa chain V-III region GOL Ig lambda chain V-II region TRO Ig heavy chain V-III region JON WIPF1 p-Y151,S,T-WASF3 Ig lambda chain V-I region NIG-64 Ig heavy chain V-III region TUR Ig kappa chain V-II region Cum Ig heavy chain V-II region WAH Ig heavy chain V-II region COR IGLV3-16(1-?) IGKC Ig heavy chain V-III region BUR Ig lambda chain V-III region SH IGLV11-55(1-?) IGLV5-37(1-?) Ig lambda chain V-III region LOI Ig heavy chain V-III region JON Ig kappa chain V-I region HK101 Ig lambda chain V-II region TOG IGHG2 IGLV2-23(1-?) Ig heavy chain V-III region HIL Ig heavy chain V-III region KOL Ig kappa chain V-I region EU Ig kappa chain V-II region RPMI 6410 Ig lambda chain V-VI region AR Ig kappa chain V-III region Ti IGLV3-25(1-?) Ig lambda chain V-II region BUR Ig lambda chain V-V region DEL BAIAP2 Ig heavy chain V-II region WAH Ig kappa chain V-I region Lay IGLV2-18(1-?) IGLV4-3(1-?) Ig lambda chain V-I region MEM Ig heavy chain V-III region WAS Ig kappa chain V-III region HIC Ig kappa chain V-IV region STH IGLV1-36(1-?) Ig kappa chain V-I region Wes NCKAP1 IGLC7 p-Y151,S,T-WASF3 Ig kappa chain V-IV region JI Ig kappa chain V-I region BAN ELMO1 BTK Ig heavy chain V-III region BRO IGLV1-40(1-?) IGLC2 Ig lambda chain V-IV region X Ig kappa chain V-I region Scw IGLV3-27(1-?) Ig kappa chain V-I region OU IGLV2-33(1-?) IGKVA18(21-?) IGHG2 N-WASP Ig heavy chain V-III region BRO p-Y150,S343,T346-WASF2 Ig kappa chain V-I region Gal Ig kappa chain V-I region Kue Ig kappa chain V-I region Roy PAK1 dimerIg kappa chain V-II region MIL Ig heavy chain V-III region TUR Ig lambda chain V-II region NIG-58 p-PLCGIg heavy chain V-III region ZAP Ig heavy chain V-I region Mot Ig heavy chain V-III region KOL Ig kappa chain V-III region HAH Ig lambda chain V region 4A GTP Ig kappa chain V-III region B6 RAC1 Ig kappa chain V-IV region B17 Ig kappa chain V-III region NG9 Ig kappa chain V-II region RPMI 6410 Ig heavy chain V-III region GA Ig lambda chain V-IV region Kern p-Y291-WAS IGLV7-43(1-?) Ig lambda chain V-IV region Kern Ig kappa chain V-III region WOL Ig heavy chain V-I region SIE Ig kappa chain V-I region Rei IGHG2 Ig kappa chain V-I region HK101 IGLC7 Ig kappa chain V-III region GOL Ig heavy chain V-III region KOL IGKV4-1(21-?) Ig lambda chain V-II region NEI Ig heavy chain V-II region MCE Ig kappa chain V-I region Wes GRB2-1 Ig kappa chain V-I region WAT IgH heavy chain V-III region VH26 precursor Ig lambda chain V-VI region NIG-48 Ig lambda chain V-IV region X Ig kappa chain V-III region GOL WIPF1 IGLV4-69(1-?) FCGR3A Ig lambda chain V-II region BO Ig lambda chain V-V region DEL p-Y160,Y171-CD3G F-actin Ig kappa chain V-III region VG Ig lambda chain V-II region BOH Ig heavy chain V-I region EU p-Y151,S,T-WASF3 Ig lambda chain V-II region BO Ig lambda chain V-IV region Hil Ig heavy chain V-III region TEI NCKIPSD Ig lambda chain V-III region SH Ig lambda chain V-III region SH Ig heavy chain V-III region BRO Ig heavy chain V-II region OU IGLV3-25(1-?) ADPNCKAP1 Ig lambda chain V-I region MEM p-Y151,S,T-WASF3 IGKV4-1(21-?) IGHV7-81(1-?) IGLV2-33(1-?) IGLV1-40(1-?) p-Y151-WASF3 IGLV7-43(1-?) Ig lambda chain V-VI region AR WAS IGLV2-11(1-?) WIPF2 Ig kappa chain V-I region Scw Ig kappa chain V-III region B6 Ig kappa chain V-I region EU Ig heavy chain V-III region DOB IGKV1-5(23-?) IgG-Ag:FCGRIIAIGLV3-27(1-?) Ig heavy chain V-III region POM IGLV3-12(1-?) Ig kappa chain V-I region DEE WRC:IRSp53/58:RAC1:GTP:PIP3Ig heavy chain V-I region ND Ig lambda chain V-III region LOI GTP p-Y150,S343,T346-WASF2 Ig heavy chain V-III region ZAP Ig heavy chain V-III region HIL Ig kappa chain V-III region GOL ARPC3 Ig kappa chain V-I region OU Ig heavy chain V-I region WOL WIPF2 IGKV1-5(23-?) NCK1 Ig kappa chain V-III region VG IGHG4 Ig kappa chain V-II region Cum NCKAP1 Ig heavy chain V-II region OU IGKV1-5(23-?) Ig kappa chain V-I region Ka Ig kappa chain V-III region Ti Ig lambda chain V-I region NEWM Ig kappa chain V-III region POM Ig lambda chain V-I region NEWM Ig kappa chain V-I region Gal Ig kappa chain V-I region DEE p-4S-ABI2 Ig kappa chain V-II region TEW ACTB(1-375) Ig lambda chain V-II region BUR Ig heavy chain V-II region COR Ig lambda chain V-III region LOI Ig kappa chain V-III region Ti Ig kappa chain V-III region WOL PiIg lambda chain V region 4A Ig lambda chain V-I region NEW IGLV1-40(1-?) Ig lambda chain V-VI region NIG-48 Ig kappa chain V-II region FR Antigen Ig kappa chain V-IV region STH pLIMK dimer:HSP-90Ig kappa chain V-II region RPMI 6410 Ig kappa chain V-I region OU p-Y151,S,T-WASF3 Ig kappa chain V-I region CAR PI(3,4,5)P3 Ig lambda chain V-III region LOI Ig heavy chain V-III region ZAP Ig kappa chain V-I region Ni Ig heavy chain V-III region CAM ARPC1A Ig lambda chain V-VI region SUT p-6Y-SYK p-Y256-WASL Ig heavy chain V-III region LAY Ig heavy chain V-III region HIL Ig heavy chain V-III region JON Ig heavy chain V-II region NEWM Ig lambda chain V-II region BOH IGHG1 clusteredIgG-Ag:p-FCGRsIg heavy chain V-III region TUR Ig kappa chain V-I region Ka Ig kappa chain V-I region Wes Ig lambda chain V-I region VOR Antigen VAV1,2,3Ig kappa chain V-I region Kue IGHG2 NCK1 Ig heavy chain V-III region JON Ig kappa chain V-III region VH Ig lambda chain V-VII region MOT Ig heavy chain V-I region ND IGLV11-55(1-?) Ig kappa chain V-IV region JI BRK1 IgH heavy chain V-III region VH26 precursor PLCG2 Ig lambda chain V-II region NIG-58 IGLV4-3(1-?) Ig heavy chain V-III region TRO Ig lambda chain V region 4A IGLV8-61(1-?) Ig heavy chain V-II region COR IGLV3-12(1-?) Ig kappa chain V-III region VH Ig lambda chain V-II region BOH Ig lambda chain V-II region BUR IGHG2 Ig kappa chain V-III region Ti Ig lambda chain V-II region MGC Ig kappa chain V-II region Cum IGHG1 Ig kappa chain V-III region VH IGLV10-54(1-?) Ig kappa chain V-II region MIL p-T566,T710,S729-PRKCE Ig kappa chain V-I region BAN IGLV5-45(1-?) IGLC3 Ig heavy chain V-II region NEWM IGLV1-36(1-?) BRK1 Ig kappa chain V region EV15 Ig heavy chain V-III region LAY IGLC6 Ig kappa chain V-I region DEE Ig kappa chain V-I region EU Ig kappa chain V-II region MIL Ig lambda chain V-II region TOG Ig kappa chain V-I region Gal FGR Ig kappa chain V-I region Hau ADPDOCK1 Ig heavy chain V-II region OU Ig heavy chain V-II region SESS IGLV5-37(1-?) IGLV3-27(1-?) Ig lambda chain V-V region DEL p-4S-ABI2 IGHV7-81(1-?) Ig lambda chain V-II region MGC Ig lambda chain V-III region SH Ig lambda chain V-II region NIG-84 Ig heavy chain V-I region SIE Ig heavy chain V-III region TIL Ig heavy chain V-III region JON IGKV1-5(23-?) PiIg kappa chain V-I region AG IGLC6 Ig kappa chain V-III region POM Ig kappa chain V-IV region B17 Ig heavy chain V-II region ARH-77 IGLV8-61(1-?) IGLV4-60(1-?) Ig lambda chain V-I region MEM Ig lambda chain V-III region LOI Ig kappa chain V-IV region B17 Ig lambda chain V-IV region Kern Ig heavy chain V-II region SESS IGHG4 Ig lambda chain V-II region NIG-84 Ig lambda chain V-I region EPS Ig heavy chain V-III region BUT Ig heavy chain V-III region TEI Ig kappa chain V-I region Ka Ig kappa chain V-III region HAH IGLV1-36(1-?) PKC-delta/epsilonIg kappa chain V-III region Ti Ig lambda chain V-II region BO Ig lambda chain V-II region MGC Ig kappa chain V-II region TEW Ig lambda chain V-IV region X Ig lambda chain V-I region NEW Ig lambda chain V-VI region WLT IGLV4-60(1-?) Ig kappa chain V-I region AU Ig kappa chain V-I region HK101 Ig kappa chain V-IV region B17 IGLV7-43(1-?) Ig heavy chain V-II region WAH Ig kappa chain V-III region Ti Ig lambda chain V-II region NEI IGLV2-18(1-?) IGLV7-43(1-?) Ig kappa chain V-I region Rei Ig heavy chain V-II region SESS Ig heavy chain V-II region OU ACTG1 p-Y288,Y304-FCGR2A Ig lambda chain V-I region EPS Ig lambda chain V-II region TRO IGHV(1-?) Ig kappa chain V-III region POM IGLV4-3(1-?) IGLV5-37(1-?) ARPC2 Ig lambda chain V-I region WAH Ig heavy chain V-III region BRO Ig heavy chain V-II region MCE IGLV2-23(1-?) Ig heavy chain V-III region TUR ARPC2 Ig lambda chain V-III region LOI Ig kappa chain V-I region Mev ADP Ig heavy chain V-III region BUT IGLV3-27(1-?) Ig heavy chain V-III region NIE ADPIGLC2 Ig heavy chain V-III region LAY Ig lambda chain V-VI region EB4 CDC42:GTPIg heavy chain V-III region NIE IGLV3-25(1-?) Ig lambda chain V-IV region Bau IGLC7 Ig heavy chain V-III region BUT NCKAP1L Ig lambda chain V-I region WAH ARPC1A Ig lambda chain V-VII region MOT WIPF2 Ig kappa chain V-III region Ti Ig kappa chain V-IV region JI Ig kappa chain V-I region Ka Ig kappa chain V-I region OU Ig heavy chain V-III region TUR p-Y151-WASF3 Ig heavy chain V-III region TEI p-Y160,Y171-CD3G Ig kappa chain V-I region Ka IGLV2-18(1-?) Ig heavy chain V-III region GA IGKV1-5(23-?) Ig heavy chain V-I region Mot IGLV8-61(1-?) Ig kappa chain V-I region Wes Ig lambda chain V-I region NIG-64 Ig kappa chain V-III region CLL Ig kappa chain V-IV region Len Ig lambda chain V region 4A IGHG2 Ig heavy chain V-III region GA Ig lambda chain V-I region NEW Ig lambda chain V-I region NIG-64 CDC42 p-Y160,Y171-CD3G FCGR3A IGLV3-25(1-?) IGKC Ig heavy chain V-III region POM IGLV2-11(1-?) Ig kappa chain V-I region AU FCGR1A Ig kappa chain V-I region WEA Ig kappa chain V-II region MIL Ig lambda chain V-VI region EB4 IGLV(23-?) Ig lambda chain V-II region NEI IGLC6 Ig lambda chain V-VI region AR FYN Ig kappa chain V-III region HIC p-Y160,Y171-CD3G IGLV2-23(1-?) Ig lambda chain V-VI region WLT ATP Ig lambda chain V-II region NEI Ig heavy chain V-II region SESS GTP IGKC Ig kappa chain V-I region AU Ig lambda chain V-I region MEM Ig kappa chain V-I region AG Ig kappa chain V-IV region JI Ig heavy chain V-I region ND Ig kappa chain V-III region IARC/BL41 Ig heavy chain V-II region HE Ig heavy chain V-III region CAM Ig lambda chain V-VI region AR Ig lambda chain V-I region VOR Ig heavy chain V-I region SIE IGLV1-44(1-?) Ig heavy chain V-III region WEA Ig kappa chain V-II region TEW Ig kappa chain V-III region VG NCKAP1 Ig heavy chain V-III region TIL IGHG1 FCGR3A IGLV4-69(1-?) BRK1 Ig kappa chain V-III region VH Ig kappa chain V-III region CLL NAD+ IGLC1 PIK3CB IGLV2-33(1-?) Ig lambda chain V-II region WIN Ig heavy chain V-III region BRO IGLV3-22(1-?) Ig heavy chain V-II region ARH-77 Ig kappa chain V-III region VG IGLV3-25(1-?) Ig kappa chain V-I region Roy Ig kappa chain V-I region Scw IGLV11-55(1-?) IGKV1-5(23-?) Ig lambda chain V-VI region SUT Ig lambda chain V-I region BL2 Ig lambda chain V-III region LOI MYH2 Ig lambda chain V-VI region SUT Ig lambda chain V-IV region X IGLV8-61(1-?) Ig lambda chain V-IV region MOL IGLV4-60(1-?) Ig kappa chain V-I region Kue IGHV(1-?) Ig heavy chain V-II region COR Ig kappa chain V-III region HIC Ig heavy chain V-III region CAM IGLV(23-?) Ig lambda chain V-I region HA Ig lambda chain V-II region NIG-84 Ig heavy chain V-II region MCE IGLV7-46(1-?) Ig kappa chain V-I region Mev Motherfilament:branchingcomplexIg lambda chain V-IV region Kern IGLV2-11(1-?) IGLV4-60(1-?) IGLV7-43(1-?) Ig kappa chain V-I region AU Ig lambda chain V-VI region SUT Ig lambda chain V-I region WAH p-Y288,Y304-FCGR2A Ig kappa chain V-IV region B17 Ig kappa chain V-I region WEA FCGR1A IGLV4-69(1-?) Ig heavy chain V-II region NEWM Ig kappa chain V-II region GM607 Ig lambda chain V-II region WIN Ig kappa chain V-II region GM607 Ig kappa chain V-I region Walker IGHV7-81(1-?) Ig heavy chain V-II region DAW Ig lambda chain V-I region EPS IGHV7-81(1-?) ITPR:I(1,4,5)P3tetramerIg lambda chain V-I region WAH GRB2-1 PLD1 Ig lambda chain V-VII region MOT Ig kappa chain V-IV region JI Ig heavy chain V-III region LAY Ig lambda chain V-I region WAH IGLV10-54(1-?) IGKC Ig kappa chain V-I region Rei Ig lambda chain V-II region MGC Ig lambda chain V-IV region Bau Ig heavy chain V-III region JON IGLV8-61(1-?) Ig kappa chain V-II region RPMI 6410 Ig kappa chain V-I region AU IGLV3-12(1-?) Ig lambda chain V-II region VIL Ig lambda chain V-II region BO Ig lambda chain V-I region WAH Ig heavy chain V-III region DOB Ig heavy chain V-II region HE Ig kappa chain V-I region Roy Ig kappa chain V-I region Wes IGLC6 IGKC IGLC6 IGHV(1-?) I(1,4,5)P3 Ig kappa chain V-III region IARC/BL41 Ig kappa chain V-IV region STH IGLV4-60(1-?) Ig kappa chain V-II region GM607 Ig heavy chain V-III region TIL Ig heavy chain V-I region HG3 IGHV(1-?) Ig lambda chain V-I region NIG-64 IGLC1 IGKV4-1(21-?) Ig kappa chain V-III region POM Ig heavy chain V-II region DAW IGLC3 IGLC3 IGLV3-22(1-?) Ig heavy chain V-I region Mot DAGsIg kappa chain V-III region HIC Ig heavy chain V-III region NIE Ig kappa chain V-I region Mev Ig heavy chain V-III region ZAP ADP Ig lambda chain V-V region DEL Ig kappa chain V-II region TEW IGHG1 Ig kappa chain V-I region Daudi Ig heavy chain V-III region ZAP Ig heavy chain V-III region KOL p-Y151,S,T-WASF1 Ig kappa chain V-I region Bi Ig lambda chain V-II region MGC Ig heavy chain V-III region GA Ig heavy chain V-II region SESS Ig lambda chain V-II region WIN Ig lambda chain V-II region TOG ITPR1 Ig kappa chain V-IV region Len Ig heavy chain V-III region BRO IGLV2-18(1-?) Ig kappa chain V-I region HK101 Ig lambda chain V-I region VOR Ig lambda chain V-VI region EB4 ACTR3 Ig kappa chain V-I region Roy Ig heavy chain V-III region GA WIPF3 IGLV2-23(1-?) IGLC7 Ig kappa chain V-I region BAN Ig kappa chain V-III region B6 Ig kappa chain V-I region Ka IGLV(23-?) Ig lambda chain V-II region MGC Ig kappa chain V-III region B6 IgH heavy chain V-III region VH26 precursor Ig lambda chain V-II region VIL Ig heavy chain V-III region JON IGLV7-43(1-?) Ig kappa chain V-II region TEW CDC42 Ig kappa chain V-IV region JI IGLV1-36(1-?) IGLV2-11(1-?) Ig heavy chain V-III region BRO IGHG2 IGLV2-23(1-?) IGLV7-43(1-?) IGLV3-27(1-?) Ig heavy chain V-III region WAS Ig lambda chain V-VI region WLT Ig kappa chain V-I region Hau CDC42 FCGR1A Ig kappa chain V-III region WOL IGLV5-37(1-?) Ig kappa chain V-I region CAR PIK3CB Ig kappa chain V-I region Rei Ig heavy chain V-II region ARH-77 CYFIP1 PI(3,4,5)P3 ATP IGLV8-61(1-?) Ig lambda chain V-VII region MOT Ig lambda chain V-I region NIG-64 Ig lambda chain V-IV region Kern Ig heavy chain V-II region DAW Ig heavy chain V-III region HIL Ig heavy chain V-III region KOL Ig heavy chain V-II region ARH-77 Ig kappa chain V-I region Bi IGLV7-46(1-?) Ig kappa chain V-I region Wes IGLV7-43(1-?) p-Y256-WASL Ig kappa chain V-II region Cum Ig heavy chain V-I region ND Ig kappa chain V-IV region Len p-S,T508-LIMK1 GTP p-6Y-CD247-1 ACTR3 p-Y151,S,T-WASF1 IGHV7-81(1-?) Ig kappa chain V-III region GOL Ig heavy chain V-I region Mot Ig kappa chain V-I region Roy Ig kappa chain V-I region Ka Ig heavy chain V-III region TUR PI(3,4,5)P3ARPC3 IGLV(23-?) FCGR1A Ig lambda chain V-III region LOI IGHG1 IGLC2 Ig kappa chain V-IV region JI Ig heavy chain V-III region BUR PiIGLV3-16(1-?) Ig heavy chain V-III region TIL Ig lambda chain V-VI region SUT Ig lambda chain V region 4A Ig kappa chain V-I region Mev Ig kappa chain V-I region CAR Ig kappa chain V-IV region Len Ig kappa chain V-III region POM Ig heavy chain V-III region TRO Ig lambda chain V-II region NIG-58 Ig heavy chain V-II region MCE Ig heavy chain V-II region HE Ig lambda chain V-I region MEM Ig heavy chain V-III region WEA p-Y150-WASF2 clusteredIgG-Ag:p-FCGRsIGLV10-54(1-?) Ig kappa chain V-II region Cum p-6Y-SYK IGHG1 ATP IGHG3 Ig kappa chain V-I region Hau Ig kappa chain V-III region Ti Ig heavy chain V-III region WEA ACTG1 Ig heavy chain V-III region BUR IgH heavy chain V-III region VH26 precursor Ig kappa chain V-I region Kue Ig heavy chain V-III region DOB p-Y291-WAS Ig heavy chain V-I region SIE IGLV11-55(1-?) Ig lambda chain V-II region TRO I(1,4,5)P3 Ig lambda chain V-II region BO CYFIP2 IGHG1 clusteredIgG-Ag:p-FCGRs:p-6Y-SYKACTR3 Ig heavy chain V-I region WOL Ig lambda chain V-IV region MOL Ig heavy chain V-II region MCE Ig lambda chain V-II region NEI IGHG1 IGKV4-1(21-?) IGKV4-1(21-?) Ig kappa chain V-III region CLL Ig lambda chain V-II region MGC Ig lambda chain V-VI region EB4 Ig heavy chain V-II region SESS Ig kappa chain V-I region AG IGLV10-54(1-?) NCKAP1L Ig heavy chain V-III region DOB Ig lambda chain V-I region MEM CD3G Ig heavy chain V-III region LAY Ig lambda chain V-IV region Hil p-4S-ABI2 IGKVA18(21-?) Ig lambda chain V-I region NIG-64 p-Y291-WAS MYH9 Ig lambda chain V-V region DEL IGLV5-37(1-?) NCKIPSD Ig lambda chain V-IV region Kern IGHV(1-?) Ig heavy chain V-I region EU Ig heavy chain V-III region TRO Ig kappa chain V-III region VH Ig lambda chain V-III region SH Ig kappa chain V-I region Bi Ig lambda chain V-I region BL2 Ig kappa chain V-III region CLL Ig heavy chain V-II region OU IGLV7-46(1-?) Ig lambda chain V-IV region Bau Ig kappa chain V-I region Mev IGLV2-18(1-?) IGKV1-5(23-?) WASF1 Ig heavy chain V-III region GAL VAV1 Ig kappa chain V-III region CLL Ig kappa chain V-III region NG9 Ig kappa chain V-III region B6 PI(3,4,5)P3 IGKV4-1(21-?) ADPIg heavy chain V-III region GAL Ig kappa chain V-I region Mev Ig kappa chain V-III region NG9 Ig heavy chain V-II region WAH Antigen Ig kappa chain V-I region HK101 Ig lambda chain V-II region WIN Ig heavy chain V-III region TRO ATPIg lambda chain V-II region WIN Ig heavy chain V-III region TEI Ig kappa chain V-I region DEE Ig lambda chain V-VII region MOT IGKC Ig kappa chain V-III region CLL PI(3,4)P2 Ig lambda chain V-II region BOH Ig kappa chain V-III region IARC/BL41 Ig heavy chain V-III region WAS CYFIP1 Active LIMK1IGLV3-22(1-?) IGLV7-46(1-?) Ig heavy chain V-II region WAH Ig kappa chain V-I region Rei IGLV2-11(1-?) Ig lambda chain V-I region EPS PI(4,5)P2 Ig lambda chain V-I region WAH IGLV8-61(1-?) Ig heavy chain V-I region Mot IGLV1-40(1-?) IGLV2-23(1-?) CD247-1 Ig kappa chain V-II region Cum Ig heavy chain V-II region NEWM Ig kappa chain V-I region Mev ABI2 Ig lambda chain V-II region BUR IGLV7-46(1-?) Ig kappa chain V-IV region JI IGKV1-5(23-?) Ig lambda chain V-VI region EB4 Ig lambda chain V-II region NIG-58 Ig heavy chain V-II region MCE Motherfilament:branchingcomplex:daughterfilamentIg kappa chain V-III region VH IGKC Ig kappa chain V-II region MIL DOCK1 p-6Y-CD247-1 Ig kappa chain V-I region Mev Ig kappa chain V-III region CLL IGKC Ig lambda chain V-III region LOI Ig lambda chain V-VI region NIG-48 IGLV2-11(1-?) Ig kappa chain V-I region Ni Ig heavy chain V-I region HG3 IGLV3-27(1-?) IGLV11-55(1-?) Ig heavy chain V-III region TIL Ig lambda chain V region 4A Ig lambda chain V region 4A RAC1 Ig heavy chain V-II region NEWM Ig kappa chain V-I region Scw GTPIg kappa chain V-I region AU p-6Y-CD247-1 Ig kappa chain V-I region BAN Ig heavy chain V-I region HG3 Ig heavy chain V-III region WEA IGLV1-36(1-?) Ig heavy chain V-III region GA Ig heavy chain V-III region CAM Ig heavy chain V-III region GA Ig lambda chain V-II region TOG GRB2-1 Ig lambda chain V-VII region MOT IGLV(23-?) CRK:DOCK180:ELMO1,ELMO2ABI2 ITPR1 Ig kappa chain V-II region FR Ig heavy chain V-III region NIE ARPC2 clusteredIgG-Ag:p-FCGRs:p-6Y-SYK:PLCGIg lambda chain V-II region TOG p-Y256-WASL Ig heavy chain V-III region JON Ig kappa chain V-II region RPMI 6410 clusteredIgG-Ag:p-FCGRs:p-6Y-SYK:VAVPI(4,5)P2 Ig lambda chain V-VII region MOT Ig heavy chain V-II region DAW Ig heavy chain V-III region GA Ig lambda chain V-VI region WLT Ig kappa chain V-III region Ti Ig lambda chain V-I region HA F-actin Ig heavy chain V-II region NEWM CRKII:DOCK180:ELMOcomplex recruitedto phagocytic cupIGLV3-22(1-?) Ig kappa chain V-III region VG ChoIGLV4-60(1-?) Ig kappa chain V-III region POM Ig kappa chain V-I region Mev Ig lambda chain V-I region HA Ig lambda chain V-VI region NIG-48 ACTG1 FCGR3A ADPIg kappa chain V-I region Ni Ig lambda chain V-II region NEI Ig heavy chain V-III region NIE Ig lambda chain V-VII region MOT IGLV3-16(1-?) Ig kappa chain V-I region Gal Ig kappa chain V-IV region Len Ig lambda chain V-VI region EB4 Ig heavy chain V-II region WAH p-Y753,Y759,Y1217-PLCG2 IGLC3 Ig heavy chain V-III region CAM Ig kappa chain V-IV region Len Ig kappa chain V-IV region Len IgG-Ag:FCGRIA:CD3GhomodimerSrc family kinases(SFKs)Ig kappa chain V-III region GOL IGKVA18(21-?) IGLV(23-?) IGKC Ig lambda chain V-III region LOI Ig heavy chain V-III region BUT BAIAP2 Ig heavy chain V-II region WAH p-6Y-SYK IGKC Ig lambda chain V-VII region MOT IGLV8-61(1-?) Ig heavy chain V-III region TUR Ig heavy chain V-III region WAS Ig heavy chain V-III region DOB Ig kappa chain V-I region Hau Ig kappa chain V-III region VG Ig heavy chain V-III region BUT IGHG4 Ig kappa chain V-I region Daudi Ig heavy chain V-III region DOB Ig kappa chain V-II region RPMI 6410 ADPIg kappa chain V-I region Kue Ig heavy chain V-III region GA Ig lambda chain V region 4A Ig kappa chain V-I region Bi IGLV(23-?) Ig kappa chain V-I region Kue Ig lambda chain V-II region VIL IGLC3 FCGR1A Ig heavy chain V-I region EU IGLV3-12(1-?) IGLV(23-?) FCGR3A Ig kappa chain V region EV15 Ig heavy chain V-II region WAH FCGR1A IgH heavy chain V-III region VH26 precursor Ig lambda chain V-II region BO PI(3,4,5)P3 Ig lambda chain V-IV region X Ig lambda chain V-II region NIG-84 Ig kappa chain V-II region Cum Ig kappa chain V-I region Roy Ig kappa chain V-I region OU Ig kappa chain V-III region HIC Ig kappa chain V-I region AG Ig kappa chain V-III region POM Ig kappa chain V-III region VG GDPIg heavy chain V-I region WOL ELMO2 IGLV(23-?) Ig lambda chain V-I region MEM Ig heavy chain V-III region ZAP Ig lambda chain V-VII region MOT Ig heavy chain V-II region NEWM IGLV4-69(1-?) Ig kappa chain V-III region B6 p-Y151,S,T-WASF1 NCK1 NCK1 Ig lambda chain V-VI region WLT Ig heavy chain V-I region EU Ig kappa chain V-I region Bi Ig kappa chain V-III region NG9 BRK1 Motherfilament:ARP2/3:actin:GDPIg kappa chain V-I region HK101 IGKVA18(21-?) Ig lambda chain V-VI region SUT ARPC1B IGLV10-54(1-?) IGLC2 Ig heavy chain V-III region POM Ig kappa chain V-III region HIC GTP Ig kappa chain V-I region BAN p-Y288,Y304-FCGR2A Ig heavy chain V-III region BUR IGLV3-25(1-?) Ig heavy chain V-I region WOL Ig kappa chain V-I region BAN IGLV2-11(1-?) Ig kappa chain V-I region AG Ig lambda chain V-I region NEW NCKAP1L IGLC6 Ig kappa chain V-IV region JI ATPIg lambda chain V-I region NIG-64 Ig lambda chain V-II region TRO Ig kappa chain V-III region HAH Ig heavy chain V-III region BUR Ig kappa chain V region EV15 IGHG4 IGLV7-43(1-?) IGLV3-25(1-?) FCGR3A p-Y151-WASF3 Ig lambda chain V-I region NIG-64 Ig kappa chain V-II region FR Ig lambda chain V-IV region X clusteredIgG-Ag:p-FCGRsIGHV(1-?) Ig kappa chain V-I region OU CYFIP2 Ig kappa chain V-II region FR ARPC5 Activated WAVE2 andWASP/N-WASP:ARP2/3complex:G-actinIGLC2 Ig lambda chain V-II region WIN Ig heavy chain V-II region WAH WAS IGLV11-55(1-?) Ig lambda chain V-II region NIG-58 Ig kappa chain V-III region SIE Ig heavy chain V-III region BUT Ig kappa chain V-IV region Len Ig kappa chain V-I region Walker SYK Ig lambda chain V-II region NEI PI(3,4,5)P3ACTG1 Ig heavy chain V-III region BUT Ig heavy chain V-III region DOB p-Y151-WASF1 IGLV4-3(1-?) Antigen ARPC4 GTP Ig kappa chain V-II region GM607 ARPC5 Ig kappa chain V-I region Lay Ig kappa chain V-I region Rei ACTB(1-375) Ig heavy chain V-III region POM PLCG1 Ig heavy chain V-III region WAS Ig lambda chain V-VI region SUT IGLV2-11(1-?) CYFIP1 IGLV5-45(1-?) Ig heavy chain V-III region BRO CDC42 Ig kappa chain V-I region HK101 p-5S-ABI1 Ig heavy chain V-III region CAM Ig kappa chain V-I region CAR p-4S-ABI2 Ig heavy chain V-III region CAM Ig kappa chain V-IV region JI IGHV7-81(1-?) Ig kappa chain V-III region HAH Ig lambda chain V-VI region NIG-48 Ig lambda chain V-VI region WLT Ig kappa chain V-I region Kue Phospho-PKC-delta/epsilonPIK3R2 Ig kappa chain V-III region VH RAC1 Ig heavy chain V-III region BRO IGHG4 WIPF3 Ig kappa chain V-II region FR IGHG1 Ig kappa chain V-I region Lay Ig heavy chain V-III region TRO IGLV5-45(1-?) Ig kappa chain V-III region HIC ATP IGKV1-5(23-?) p-Y160,Y171-CD3G G-actinIGLV3-12(1-?) IGLV10-54(1-?) IGLV11-55(1-?) Ig kappa chain V-I region Wes Ig lambda chain V-IV region Hil ATP Ig kappa chain V-III region WOL Ig kappa chain V-III region SIE Ig heavy chain V-III region KOL IGLV5-37(1-?) IGLC2 Ig kappa chain V-III region HIC Ig heavy chain V-III region TEI WIP family proteinsIg kappa chain V-I region Hau Ig heavy chain V-II region DAW Ig lambda chain V-I region HA ATPIg lambda chain V-II region BUR Ig heavy chain V-III region ZAP IGLV2-18(1-?) Ig lambda chain V-I region NEWM Ig heavy chain V-II region WAH RAC1 GRB2-1 Ig kappa chain V-II region TEW IGHG3 Ig heavy chain V-I region Mot IGKC p-Y151-WASF1 Ig kappa chain V-III region HIC p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3Ig kappa chain V-I region BAN NCKAP1 pCofilin: ActiveLIMK-1Ig lambda chain V-VI region AR Ig heavy chain V-III region BUT Ig heavy chain V-II region COR Ig lambda chain V-VI region SUT Ig lambda chain V-I region BL2 Ig heavy chain V-III region BUR Ig heavy chain V-III region NIE Ig lambda chain V-IV region X Ig kappa chain V-III region IARC/BL41 Ig lambda chain V-IV region Bau Ig kappa chain V region EV15 Ig kappa chain V-I region Lay Ig heavy chain V-III region WAS Ig heavy chain V-III region WAS Ig heavy chain V-I region Mot Ig heavy chain V-II region WAH Ig kappa chain V-I region HK101 Ig heavy chain V-II region DAW Ig kappa chain V-II region Cum CDC42:GTP:WASP/N-WASP:WIP:SH3 proteinsIg lambda chain V-VII region MOT MyosinIg kappa chain V-III region GOL IGLC3 Ig kappa chain V-II region GM607 Ig kappa chain V-I region Lay Ig heavy chain V-II region SESS Ig heavy chain V-III region HIL IGLV3-25(1-?) p-Y256-WASL Ig lambda chain V-IV region Bau CYFIP1 Ig lambda chain V-VI region SUT Ig lambda chain V-V region DEL Ig kappa chain V-II region TEW FCGR2A Antigen IGHV7-81(1-?) Ig lambda chain V-I region NEWM IGLV11-55(1-?) Ig heavy chain V-II region OU Ig heavy chain V-II region MCE p-T,Y MAPK dimersIg lambda chain V-IV region MOL Ig heavy chain V-III region HIL Ig lambda chain V-II region BOH ACTB(1-375) Ig kappa chain V-I region WEA Ig heavy chain V-I region SIE Ig heavy chain V-I region HG3 CYFIP2 Ig lambda chain V-II region BOH p-6Y-SYK NCKIPSD Ig kappa chain V-I region Walker PI(4,5)P2 IGLV2-33(1-?) Ig lambda chain V-I region BL2 Ig kappa chain V-III region VH Ig kappa chain V-I region AG ACTR2 Ig kappa chain V-III region HIC Ig heavy chain V-I region HG3 Ig heavy chain V-III region WEA Ig kappa chain V-IV region Len IGLV3-12(1-?) Ig kappa chain V-III region GOL Ig lambda chain V-II region TRO Ig kappa chain V-I region Ka FCGR3A WIPF3 Ig lambda chain V-II region BUR Ig lambda chain V-II region BOH Ig heavy chain V-III region KOL GRB2-1 Ig kappa chain V region EV15 ARPC1B Ig lambda chain V-VI region NIG-48 NCK1 Ig heavy chain V-II region HE Ig lambda chain V-I region MEM Ig kappa chain V-I region Daudi CDC42 IGLC7 Ig lambda chain V-I region WAH PI(4,5)P2 Ig heavy chain V-I region HG3 ITPR1 Myosin-X dimerIg kappa chain V-III region IARC/BL41 Ig heavy chain V-III region TIL Ig lambda chain V-II region BOH Ig kappa chain V-I region Rei IGLV1-44(1-?) Ig heavy chain V-III region ZAP ABI1 Ig kappa chain V-III region VG Ig kappa chain V-III region VH IGLV4-60(1-?) Ig kappa chain V-IV region Len Ig kappa chain V-I region OU Ig heavy chain V-I region Mot Ig lambda chain V region 4A IGKV1-5(23-?) Ig kappa chain V-III region IARC/BL41 Ca2+ACTB(1-375) FCGR1A Ig kappa chain V-III region Ti IgH heavy chain V-III region VH26 precursor ITPR3 Ig kappa chain V-I region HK101 Ig kappa chain V-III region IARC/BL41 Ig heavy chain V-II region SESS GTPIGLV2-11(1-?) IGLV3-16(1-?) IGKV4-1(21-?) Ig kappa chain V-I region Ni H2OIg lambda chain V-VI region WLT Ig kappa chain V-I region Ni WIPF3 Ig lambda chain V-I region MEM Ig kappa chain V-III region SIE p-S,T508-LIMK1 p-T508-LIMK1ARPC3 Ig heavy chain V-III region NIE Ig heavy chain V-II region HE p-Y151,S,T-WASF1 IGLC3 ATPIg kappa chain V-II region Cum Ig lambda chain V-IV region Hil Ig kappa chain V-III region IARC/BL41 Ig lambda chain V-II region BO Ig lambda chain V-II region BOH Ig lambda chain V-VI region EB4 3131, 84313939


Description

Phagocytosis is one of the important innate immune responses that function to eliminate invading infectious agents. Monocytes, macrophages, and neutrophils are the professional phagocytic cells. Phagocytosis is a complex process involving the recognition of invading foreign particles by specific types of phagocytic receptors and the subsequent internalization of the particles. Fc gamma receptors (FCGRs) are among the best studied phagocytic receptors that bind to Fc portion of immunoglobulin G (IgG). Through their antigen binding F(ab) end, antibodies bind to specific antigen while their constant (Fc) region binds to FCGRs on phagocytes. The clustering of FCGRs by IgG antibodies on the phagocyte initiates a variety of signals, which lead, through the reorganisation of actin cytoskeleton and membrane remodelling, to the formation of pseudopod and phagosome. Fc gamma receptors are classified into three classes: FCGRI, FCGRII and FCGRIII. Each class of these FCGRs consists of several individual isoforms. Among all these isoforms FCGRI, FCGRIIA and FCGRIIIA, are able to mediate phagocytosis (Joshi et al. 2006, Garcia Garcia & Rosales 2002, Nimmerjahn & Ravetch 2006). View original pathway at:Reactome.

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Bibliography

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  60. Miki H, Suetsugu S, Takenawa T.; ''WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac.''; PubMed Europe PMC Scholia
  61. Chong C, Tan L, Lim L, Manser E.; ''The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity.''; PubMed Europe PMC Scholia
  62. Nakanishi O, Suetsugu S, Yamazaki D, Takenawa T.; ''Effect of WAVE2 phosphorylation on activation of the Arp2/3 complex.''; PubMed Europe PMC Scholia
  63. Corrotte M, Chasserot-Golaz S, Huang P, Du G, Ktistakis NT, Frohman MA, Vitale N, Bader MF, Grant NJ.; ''Dynamics and function of phospholipase D and phosphatidic acid during phagocytosis.''; PubMed Europe PMC Scholia
  64. Mitchell MA, Huang MM, Chien P, Indik ZK, Pan XQ, Schreiber AD.; ''Substitutions and deletions in the cytoplasmic domain of the phagocytic receptor Fc gamma RIIA: effect on receptor tyrosine phosphorylation and phagocytosis.''; PubMed Europe PMC Scholia
  65. Le Clainche C, Pantaloni D, Carlier MF.; ''ATP hydrolysis on actin-related protein 2/3 complex causes debranching of dendritic actin arrays.''; PubMed Europe PMC Scholia
  66. Deckert M, Tartare-Deckert S, Couture C, Mustelin T, Altman A.; ''Functional and physical interactions of Syk family kinases with the Vav proto-oncogene product.''; PubMed Europe PMC Scholia
  67. Massol P, Montcourrier P, Guillemot JC, Chavrier P.; ''Fc receptor-mediated phagocytosis requires CDC42 and Rac1.''; PubMed Europe PMC Scholia
  68. Xu X, Chong AS.; ''Vav in natural killer cells is tyrosine phosphorylated upon cross-linking of Fc gamma RIIIA and is constitutively associated with a serine/threonine kinase.''; PubMed Europe PMC Scholia
  69. Scott CC, Dobson W, Botelho RJ, Coady-Osberg N, Chavrier P, Knecht DA, Heath C, Stahl P, Grinstein S.; ''Phosphatidylinositol-4,5-bisphosphate hydrolysis directs actin remodeling during phagocytosis.''; PubMed Europe PMC Scholia
  70. Park H, Cox D.; ''Cdc42 regulates Fc gamma receptor-mediated phagocytosis through the activation and phosphorylation of Wiskott-Aldrich syndrome protein (WASP) and neural-WASP.''; PubMed Europe PMC Scholia
  71. Mullins RD, Heuser JA, Pollard TD.; ''The interaction of Arp2/3 complex with actin: nucleation, high affinity pointed end capping, and formation of branching networks of filaments.''; PubMed Europe PMC Scholia
  72. Kiener PA, Rankin BM, Burkhardt AL, Schieven GL, Gilliland LK, Rowley RB, Bolen JB, Ledbetter JA.; ''Cross-linking of Fc gamma receptor I (Fc gamma RI) and receptor II (Fc gamma RII) on monocytic cells activates a signal transduction pathway common to both Fc receptors that involves the stimulation of p72 Syk protein tyrosine kinase.''; PubMed Europe PMC Scholia
  73. Chavrier P.; ''May the force be with you: Myosin-X in phagocytosis.''; PubMed Europe PMC Scholia
  74. Hall AB, Gakidis MA, Glogauer M, Wilsbacher JL, Gao S, Swat W, Brugge JS.; ''Requirements for Vav guanine nucleotide exchange factors and Rho GTPases in FcgammaR- and complement-mediated phagocytosis.''; PubMed Europe PMC Scholia
  75. Moon KD, Post CB, Durden DL, Zhou Q, De P, Harrison ML, Geahlen RL.; ''Molecular basis for a direct interaction between the Syk protein-tyrosine kinase and phosphoinositide 3-kinase.''; PubMed Europe PMC Scholia
  76. Wang QJ.; ''PKD at the crossroads of DAG and PKC signaling.''; PubMed Europe PMC Scholia
  77. Amann KJ, Pollard TD.; ''The Arp2/3 complex nucleates actin filament branches from the sides of pre-existing filaments.''; PubMed Europe PMC Scholia
  78. Nimmerjahn F, Ravetch JV.; ''Fcgamma receptors: old friends and new family members.''; PubMed Europe PMC Scholia
  79. Agarwal A, Salem P, Robbins KC.; ''Involvement of p72syk, a protein-tyrosine kinase, in Fc gamma receptor signaling.''; PubMed Europe PMC Scholia
  80. Kim YJ, Sekiya F, Poulin B, Bae YS, Rhee SG.; ''Mechanism of B-cell receptor-induced phosphorylation and activation of phospholipase C-gamma2.''; PubMed Europe PMC Scholia
  81. Millard TH, Sharp SJ, Machesky LM.; ''Signalling to actin assembly via the WASP (Wiskott-Aldrich syndrome protein)-family proteins and the Arp2/3 complex.''; PubMed Europe PMC Scholia
  82. Le Clainche C, Carlier MF.; ''Regulation of actin assembly associated with protrusion and adhesion in cell migration.''; PubMed Europe PMC Scholia
  83. Ernst LK, Duchemin AM, Anderson CL.; ''Association of the high-affinity receptor for IgG (Fc gamma RI) with the gamma subunit of the IgE receptor.''; PubMed Europe PMC Scholia
  84. Tsang E, Giannetti AM, Shaw D, Dinh M, Tse JK, Gandhi S, Ho H, Wang S, Papp E, Bradshaw JM.; ''Molecular mechanism of the Syk activation switch.''; PubMed Europe PMC Scholia
  85. Swanson JA, Johnson MT, Beningo K, Post P, Mooseker M, Araki N.; ''A contractile activity that closes phagosomes in macrophages.''; PubMed Europe PMC Scholia
  86. Takeuchi M, Harigai M, Momohara S, Ball E, Abe J, Furuichi K, Kamatani N.; ''Cloning and characterization of DPPL1 and DPPL2, representatives of a novel type of mammalian phosphatidate phosphatase.''; PubMed Europe PMC Scholia
  87. Sekiya F, Poulin B, Kim YJ, Rhee SG.; ''Mechanism of tyrosine phosphorylation and activation of phospholipase C-gamma 1. Tyrosine 783 phosphorylation is not sufficient for lipase activation.''; PubMed Europe PMC Scholia
  88. Zalevsky J, Lempert L, Kranitz H, Mullins RD.; ''Different WASP family proteins stimulate different Arp2/3 complex-dependent actin-nucleating activities.''; PubMed Europe PMC Scholia
  89. Brooks DG, Qiu WQ, Luster AD, Ravetch JV.; ''Structure and expression of human IgG FcRII(CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes.''; PubMed Europe PMC Scholia
  90. Strzelecka A, Kwiatkowska K, Sobota A.; ''Tyrosine phosphorylation and Fcgamma receptor-mediated phagocytosis.''; PubMed Europe PMC Scholia
  91. Ghazizadeh S, Bolen JB, Fleit HB.; ''Tyrosine phosphorylation and association of Syk with Fc gamma RII in monocytic THP-1 cells.''; PubMed Europe PMC Scholia
  92. Cory GO, Garg R, Cramer R, Ridley AJ.; ''Phosphorylation of tyrosine 291 enhances the ability of WASp to stimulate actin polymerization and filopodium formation. Wiskott-Aldrich Syndrome protein.''; PubMed Europe PMC Scholia
  93. van Vugt MJ, Heijnen IA, Capel PJ, Park SY, Ra C, Saito T, Verbeek JS, van de Winkel JG.; ''FcR gamma-chain is essential for both surface expression and function of human Fc gamma RI (CD64) in vivo.''; PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
118475view20:32, 27 May 2021FinterlyRemoved incorrect and duplicated openControlledVocabulary PW:0000234
114947view16:47, 25 January 2021ReactomeTeamReactome version 75
113391view11:46, 2 November 2020ReactomeTeamReactome version 74
112853view13:31, 12 October 2020DeSlFixing ontology tag error
112849view13:02, 12 October 2020DeSlOntology Term : 'innate immune response pathway' added !
112596view15:57, 9 October 2020ReactomeTeamReactome version 73
101512view11:37, 1 November 2018ReactomeTeamreactome version 66
101048view21:19, 31 October 2018ReactomeTeamreactome version 65
100579view19:52, 31 October 2018ReactomeTeamreactome version 64
100128view16:38, 31 October 2018ReactomeTeamreactome version 63
99678view15:07, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99271view12:45, 31 October 2018ReactomeTeamreactome version 62
94053view13:54, 16 August 2017ReactomeTeamreactome version 61
93681view11:30, 9 August 2017ReactomeTeamreactome version 61
89466view13:21, 15 September 2016Mkutmonfix ontology tag annotation
87448view13:50, 22 July 2016MkutmonOntology Term : 'PW:0000234' added !
86805view09:26, 11 July 2016ReactomeTeamreactome version 56
83122view10:02, 18 November 2015ReactomeTeamVersion54
81461view12:59, 21 August 2015ReactomeTeamVersion53
76936view08:20, 17 July 2014ReactomeTeamFixed remaining interactions
76641view12:01, 16 July 2014ReactomeTeamFixed remaining interactions
75971view10:02, 11 June 2014ReactomeTeamRe-fixing comment source
75674view10:59, 10 June 2014ReactomeTeamReactome 48 Update
75029view13:54, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74673view08:44, 30 April 2014ReactomeTeamNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
2-LysophosphatidylcholineMetaboliteCHEBI:17504 (ChEBI)
ABI1 ProteinQ8IZP0 (Uniprot-TrEMBL)
ABI2 ProteinQ9NYB9 (Uniprot-TrEMBL)
ABL1ProteinP00519 (Uniprot-TrEMBL)
ACTB(1-375) ProteinP60709 (Uniprot-TrEMBL)
ACTG1 ProteinP63261 (Uniprot-TrEMBL)
ACTR2 ProteinP61160 (Uniprot-TrEMBL)
ACTR3 ProteinP61158 (Uniprot-TrEMBL)
ADP MetaboliteCHEBI:16761 (ChEBI)
ADPMetaboliteCHEBI:16761 (ChEBI)
AHCYL1 ProteinO43865 (Uniprot-TrEMBL)
AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramerComplexR-HSA-5226920 (Reactome)
ARAMetaboliteCHEBI:15843 (ChEBI)
ARP2/3 complex (ATP bound)ComplexR-HSA-1861670 (Reactome)
ARPC1A ProteinQ92747 (Uniprot-TrEMBL)
ARPC1B ProteinO15143 (Uniprot-TrEMBL)
ARPC2 ProteinO15144 (Uniprot-TrEMBL)
ARPC3 ProteinO15145 (Uniprot-TrEMBL)
ARPC4 ProteinP59998 (Uniprot-TrEMBL)
ARPC5 ProteinO15511 (Uniprot-TrEMBL)
ATP MetaboliteCHEBI:15422 (ChEBI)
ATPMetaboliteCHEBI:15422 (ChEBI)
Actin filament bound Myosin-XComplexR-HSA-1861625 (Reactome)
Actin:ADPComplexR-HSA-202994 (Reactome)
Activated WAVE2 and

WASP/N-WASP:ARP2/3

complex:G-actin		ComplexR-HSA-442565 (Reactome)
Activated WAVE2 and WASP/N-WASPComplexR-HSA-2197675 (Reactome)
Active LIMK1ComplexR-HSA-419630 (Reactome)
Antigen R-NUL-173548 (Reactome)
Antigen-antibody complexComplexR-HSA-173552 (Reactome)
BAIAP2 ProteinQ9UQB8 (Uniprot-TrEMBL)
BAIAP2ProteinQ9UQB8 (Uniprot-TrEMBL)
BRK1 ProteinQ8WUW1 (Uniprot-TrEMBL)
BTK ProteinQ06187 (Uniprot-TrEMBL)
CD247-1 ProteinP20963-1 (Uniprot-TrEMBL)
CD3G ProteinP09693 (Uniprot-TrEMBL)
CDC42 ProteinP60953 (Uniprot-TrEMBL)
CDC42:GDPComplexR-HSA-418830 (Reactome)
CDC42:GTP, RAC1:GTPComplexR-HSA-389778 (Reactome)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteinsComplexR-HSA-2197683 (Reactome)
CDC42:GTP:WASP/N-WASPComplexR-HSA-442584 (Reactome)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteinsComplexR-HSA-2197680 (Reactome)
CDC42:GTPComplexR-HSA-182921 (Reactome)
CFL1ProteinP23528 (Uniprot-TrEMBL)
CRK ProteinP46108 (Uniprot-TrEMBL)
CRK:DOCK180:ELMO1,ELMO2ComplexR-HSA-2029141 (Reactome)
CRKII:DOCK180:ELMO

complex recruited

to phagocytic cup		ComplexR-HSA-2029130 (Reactome)
CYFIP1 ProteinQ7L576 (Uniprot-TrEMBL)
CYFIP2 ProteinQ96F07 (Uniprot-TrEMBL)
Ca2+MetaboliteCHEBI:29108 (ChEBI)
ChoMetaboliteCHEBI:15354 (ChEBI)
DAGsMetaboliteCHEBI:18035 (ChEBI)
DOCK1 ProteinQ14185 (Uniprot-TrEMBL)
ELMO1 ProteinQ92556 (Uniprot-TrEMBL)
ELMO2 ProteinQ96JJ3 (Uniprot-TrEMBL)
F-actin R-HSA-201877 (Reactome)
F-actinR-HSA-201877 (Reactome)
FAK1 ProteinQ05397 (Uniprot-TrEMBL)
FCGR1A ProteinP12314 (Uniprot-TrEMBL)
FCGR2A ProteinP12318 (Uniprot-TrEMBL)
FCGR2AProteinP12318 (Uniprot-TrEMBL)
FCGR3A ProteinP08637 (Uniprot-TrEMBL)
FCGRIA:CD3G homodimerComplexR-HSA-2029093 (Reactome)
FCGRIIIA:CD3G/CD3Z dimersComplexR-HSA-2029097 (Reactome)
FGR ProteinP09769 (Uniprot-TrEMBL)
FYN ProteinP06241 (Uniprot-TrEMBL)
G-actinComplexR-HSA-201857 (Reactome)
GDP MetaboliteCHEBI:17552 (ChEBI)
GDPMetaboliteCHEBI:17552 (ChEBI)
GRB2-1 ProteinP62993-1 (Uniprot-TrEMBL)
GTP MetaboliteCHEBI:15996 (ChEBI)
GTPMetaboliteCHEBI:15996 (ChEBI)
H2OMetaboliteCHEBI:15377 (ChEBI)
HCK ProteinP08631 (Uniprot-TrEMBL)
HSP90AA1 ProteinP07900 (Uniprot-TrEMBL)
HSP90AA1,HSP90AB1ComplexR-HSA-419619 (Reactome)
HSP90AB1 ProteinP08238 (Uniprot-TrEMBL)
I(1,4,5)P3 MetaboliteCHEBI:16595 (ChEBI)
I(1,4,5)P3MetaboliteCHEBI:16595 (ChEBI)
IGHG1 ProteinP01857 (Uniprot-TrEMBL)
IGHG2 ProteinP01859 (Uniprot-TrEMBL)
IGHG3 ProteinP01860 (Uniprot-TrEMBL)
IGHG4 ProteinP01861 (Uniprot-TrEMBL)
IGHV(1-?) ProteinA2KUC3 (Uniprot-TrEMBL)
IGHV7-81(1-?) ProteinQ6PIL0 (Uniprot-TrEMBL)
IGKC ProteinP01834 (Uniprot-TrEMBL)
IGKV1-5(23-?) ProteinP01602 (Uniprot-TrEMBL)
IGKV4-1(21-?) ProteinP06312 (Uniprot-TrEMBL)
IGKVA18(21-?) ProteinA2NJV5 (Uniprot-TrEMBL)
IGLC1 ProteinP0CG04 (Uniprot-TrEMBL)
IGLC2 ProteinP0CG05 (Uniprot-TrEMBL)
IGLC3 ProteinP0CG06 (Uniprot-TrEMBL)
IGLC6 ProteinP0CF74 (Uniprot-TrEMBL)
IGLC7 ProteinA0M8Q6 (Uniprot-TrEMBL)
IGLV(23-?) ProteinA2NXD2 (Uniprot-TrEMBL)
IGLV1-36(1-?) ProteinQ5NV67 (Uniprot-TrEMBL)
IGLV1-40(1-?) ProteinQ5NV69 (Uniprot-TrEMBL)
IGLV1-44(1-?) ProteinQ5NV81 (Uniprot-TrEMBL)
IGLV10-54(1-?) ProteinQ5NV86 (Uniprot-TrEMBL)
IGLV11-55(1-?) ProteinQ5NV87 (Uniprot-TrEMBL)
IGLV2-11(1-?) ProteinQ5NV84 (Uniprot-TrEMBL)
IGLV2-18(1-?) ProteinQ5NV65 (Uniprot-TrEMBL)
IGLV2-23(1-?) ProteinQ5NV89 (Uniprot-TrEMBL)
IGLV2-33(1-?) ProteinQ5NV66 (Uniprot-TrEMBL)
IGLV3-12(1-?) ProteinQ5NV85 (Uniprot-TrEMBL)
IGLV3-16(1-?) ProteinQ5NV64 (Uniprot-TrEMBL)
IGLV3-22(1-?) ProteinQ5NV75 (Uniprot-TrEMBL)
IGLV3-25(1-?) ProteinQ5NV90 (Uniprot-TrEMBL)
IGLV3-27(1-?) ProteinQ5NV91 (Uniprot-TrEMBL)
IGLV4-3(1-?) ProteinQ5NV61 (Uniprot-TrEMBL)
IGLV4-60(1-?) ProteinQ5NV79 (Uniprot-TrEMBL)
IGLV4-69(1-?) ProteinQ5NV92 (Uniprot-TrEMBL)
IGLV5-37(1-?) ProteinQ5NV68 (Uniprot-TrEMBL)
IGLV5-45(1-?) ProteinQ5NV82 (Uniprot-TrEMBL)
IGLV7-43(1-?) ProteinQ5NV80 (Uniprot-TrEMBL)
IGLV7-46(1-?) ProteinQ5NV83 (Uniprot-TrEMBL)
IGLV8-61(1-?) ProteinQ5NV62 (Uniprot-TrEMBL)
IP3 receptor homotetramerComplexR-HSA-169686 (Reactome)
ITPR1 ProteinQ14643 (Uniprot-TrEMBL)
ITPR2 ProteinQ14571 (Uniprot-TrEMBL)
ITPR3 ProteinQ14573 (Uniprot-TrEMBL)
ITPR:I(1,4,5)P3 tetramerComplexR-HSA-169696 (Reactome)
Ig heavy chain V-I region EU ProteinP01742 (Uniprot-TrEMBL)
Ig heavy chain V-I region HG3 ProteinP01743 (Uniprot-TrEMBL)
Ig heavy chain V-I region Mot ProteinP06326 (Uniprot-TrEMBL)
Ig heavy chain V-I region ND ProteinP01744 (Uniprot-TrEMBL)
Ig heavy chain V-I region SIE ProteinP01761 (Uniprot-TrEMBL)
Ig heavy chain V-I region WOL ProteinP01760 (Uniprot-TrEMBL)
Ig heavy chain V-II region ARH-77 ProteinP06331 (Uniprot-TrEMBL)
Ig heavy chain V-II region COR ProteinP01815 (Uniprot-TrEMBL)
Ig heavy chain V-II region DAW ProteinP01816 (Uniprot-TrEMBL)
Ig heavy chain V-II region HE ProteinP01818 (Uniprot-TrEMBL)
Ig heavy chain V-II region MCE ProteinP01817 (Uniprot-TrEMBL)
Ig heavy chain V-II region NEWM ProteinP01825 (Uniprot-TrEMBL)
Ig heavy chain V-II region OU ProteinP01814 (Uniprot-TrEMBL)
Ig heavy chain V-II region SESS ProteinP04438 (Uniprot-TrEMBL)
Ig heavy chain V-II region WAH ProteinP01824 (Uniprot-TrEMBL)
Ig heavy chain V-III region BRO ProteinP01766 (Uniprot-TrEMBL)
Ig heavy chain V-III region BUR ProteinP01773 (Uniprot-TrEMBL)
Ig heavy chain V-III region BUT ProteinP01767 (Uniprot-TrEMBL)
Ig heavy chain V-III region CAM ProteinP01768 (Uniprot-TrEMBL)
Ig heavy chain V-III region DOB ProteinP01782 (Uniprot-TrEMBL)
Ig heavy chain V-III region GA ProteinP01769 (Uniprot-TrEMBL)
Ig heavy chain V-III region GAL ProteinP01781 (Uniprot-TrEMBL)
Ig heavy chain V-III region HIL ProteinP01771 (Uniprot-TrEMBL)
Ig heavy chain V-III region JON ProteinP01780 (Uniprot-TrEMBL)
Ig heavy chain V-III region KOL ProteinP01772 (Uniprot-TrEMBL)
Ig heavy chain V-III region LAY ProteinP01775 (Uniprot-TrEMBL)
Ig heavy chain V-III region NIE ProteinP01770 (Uniprot-TrEMBL)
Ig heavy chain V-III region POM ProteinP01774 (Uniprot-TrEMBL)
Ig heavy chain V-III region TEI ProteinP01777 (Uniprot-TrEMBL)
Ig heavy chain V-III region TIL ProteinP01765 (Uniprot-TrEMBL)
Ig heavy chain V-III region TRO ProteinP01762 (Uniprot-TrEMBL)
Ig heavy chain V-III region TUR ProteinP01779 (Uniprot-TrEMBL)
Ig heavy chain V-III region WAS ProteinP01776 (Uniprot-TrEMBL)
Ig heavy chain V-III region WEA ProteinP01763 (Uniprot-TrEMBL)
Ig heavy chain V-III region ZAP ProteinP01778 (Uniprot-TrEMBL)
Ig kappa chain V region EV15 ProteinP06315 (Uniprot-TrEMBL)
Ig kappa chain V-I region AG ProteinP01593 (Uniprot-TrEMBL)
Ig kappa chain V-I region AU ProteinP01594 (Uniprot-TrEMBL)
Ig kappa chain V-I region BAN ProteinP04430 (Uniprot-TrEMBL)
Ig kappa chain V-I region Bi ProteinP01595 (Uniprot-TrEMBL)
Ig kappa chain V-I region CAR ProteinP01596 (Uniprot-TrEMBL)
Ig kappa chain V-I region DEE ProteinP01597 (Uniprot-TrEMBL)
Ig kappa chain V-I region Daudi ProteinP04432 (Uniprot-TrEMBL)
Ig kappa chain V-I region EU ProteinP01598 (Uniprot-TrEMBL)
Ig kappa chain V-I region Gal ProteinP01599 (Uniprot-TrEMBL)
Ig kappa chain V-I region HK101 ProteinP01601 (Uniprot-TrEMBL)
Ig kappa chain V-I region Hau ProteinP01600 (Uniprot-TrEMBL)
Ig kappa chain V-I region Ka ProteinP01603 (Uniprot-TrEMBL)
Ig kappa chain V-I region Kue ProteinP01604 (Uniprot-TrEMBL)
Ig kappa chain V-I region Lay ProteinP01605 (Uniprot-TrEMBL)
Ig kappa chain V-I region Mev ProteinP01612 (Uniprot-TrEMBL)
Ig kappa chain V-I region Ni ProteinP01613 (Uniprot-TrEMBL)
Ig kappa chain V-I region OU ProteinP01606 (Uniprot-TrEMBL)
Ig kappa chain V-I region Rei ProteinP01607 (Uniprot-TrEMBL)
Ig kappa chain V-I region Roy ProteinP01608 (Uniprot-TrEMBL)
Ig kappa chain V-I region Scw ProteinP01609 (Uniprot-TrEMBL)
Ig kappa chain V-I region WAT ProteinP80362 (Uniprot-TrEMBL)
Ig kappa chain V-I region WEA ProteinP01610 (Uniprot-TrEMBL)
Ig kappa chain V-I region Walker ProteinP04431 (Uniprot-TrEMBL)
Ig kappa chain V-I region Wes ProteinP01611 (Uniprot-TrEMBL)
Ig kappa chain V-II region Cum ProteinP01614 (Uniprot-TrEMBL)
Ig kappa chain V-II region FR ProteinP01615 (Uniprot-TrEMBL)
Ig kappa chain V-II region GM607 ProteinP06309 (Uniprot-TrEMBL)
Ig kappa chain V-II region MIL ProteinP01616 (Uniprot-TrEMBL)
Ig kappa chain V-II region RPMI 6410 ProteinP06310 (Uniprot-TrEMBL)
Ig kappa chain V-II region TEW ProteinP01617 (Uniprot-TrEMBL)
Ig kappa chain V-III region B6 ProteinP01619 (Uniprot-TrEMBL)
Ig kappa chain V-III region CLL ProteinP04207 (Uniprot-TrEMBL)
Ig kappa chain V-III region GOL ProteinP04206 (Uniprot-TrEMBL)
Ig kappa chain V-III region HAH ProteinP18135 (Uniprot-TrEMBL)
Ig kappa chain V-III region HIC ProteinP18136 (Uniprot-TrEMBL)
Ig kappa chain V-III region IARC/BL41 ProteinP06311 (Uniprot-TrEMBL)
Ig kappa chain V-III region NG9 ProteinP01621 (Uniprot-TrEMBL)
Ig kappa chain V-III region POM ProteinP01624 (Uniprot-TrEMBL)
Ig kappa chain V-III region SIE ProteinP01620 (Uniprot-TrEMBL)
Ig kappa chain V-III region Ti ProteinP01622 (Uniprot-TrEMBL)
Ig kappa chain V-III region VG ProteinP04433 (Uniprot-TrEMBL)
Ig kappa chain V-III region VH ProteinP04434 (Uniprot-TrEMBL)
Ig kappa chain V-III region WOL ProteinP01623 (Uniprot-TrEMBL)
Ig kappa chain V-IV region B17 ProteinP06314 (Uniprot-TrEMBL)
Ig kappa chain V-IV region JI ProteinP06313 (Uniprot-TrEMBL)
Ig kappa chain V-IV region Len ProteinP01625 (Uniprot-TrEMBL)
Ig kappa chain V-IV region STH ProteinP83593 (Uniprot-TrEMBL)
Ig lambda chain V region 4A ProteinP04211 (Uniprot-TrEMBL)
Ig lambda chain V-I region BL2 ProteinP06316 (Uniprot-TrEMBL)
Ig lambda chain V-I region EPS ProteinP06888 (Uniprot-TrEMBL)
Ig lambda chain V-I region HA ProteinP01700 (Uniprot-TrEMBL)
Ig lambda chain V-I region MEM ProteinP06887 (Uniprot-TrEMBL)
Ig lambda chain V-I region NEW ProteinP01701 (Uniprot-TrEMBL)
Ig lambda chain V-I region NEWM ProteinP01703 (Uniprot-TrEMBL)
Ig lambda chain V-I region NIG-64 ProteinP01702 (Uniprot-TrEMBL)
Ig lambda chain V-I region VOR ProteinP01699 (Uniprot-TrEMBL)
Ig lambda chain V-I region WAH ProteinP04208 (Uniprot-TrEMBL)
Ig lambda chain V-II region BO ProteinP01710 (Uniprot-TrEMBL)
Ig lambda chain V-II region BOH ProteinP01706 (Uniprot-TrEMBL)
Ig lambda chain V-II region BUR ProteinP01708 (Uniprot-TrEMBL)
Ig lambda chain V-II region MGC ProteinP01709 (Uniprot-TrEMBL)
Ig lambda chain V-II region NEI ProteinP01705 (Uniprot-TrEMBL)
Ig lambda chain V-II region NIG-58 ProteinP01713 (Uniprot-TrEMBL)
Ig lambda chain V-II region NIG-84 ProteinP04209 (Uniprot-TrEMBL)
Ig lambda chain V-II region TOG ProteinP01704 (Uniprot-TrEMBL)
Ig lambda chain V-II region TRO ProteinP01707 (Uniprot-TrEMBL)
Ig lambda chain V-II region VIL ProteinP01711 (Uniprot-TrEMBL)
Ig lambda chain V-II region WIN ProteinP01712 (Uniprot-TrEMBL)
Ig lambda chain V-III region LOI ProteinP80748 (Uniprot-TrEMBL)
Ig lambda chain V-III region SH ProteinP01714 (Uniprot-TrEMBL)
Ig lambda chain V-IV region Bau ProteinP01715 (Uniprot-TrEMBL)
Ig lambda chain V-IV region Hil ProteinP01717 (Uniprot-TrEMBL)
Ig lambda chain V-IV region Kern ProteinP01718 (Uniprot-TrEMBL)
Ig lambda chain V-IV region MOL ProteinP06889 (Uniprot-TrEMBL)
Ig lambda chain V-IV region X ProteinP01716 (Uniprot-TrEMBL)
Ig lambda chain V-V region DEL ProteinP01719 (Uniprot-TrEMBL)
Ig lambda chain V-VI region AR ProteinP01721 (Uniprot-TrEMBL)
Ig lambda chain V-VI region EB4 ProteinP06319 (Uniprot-TrEMBL)
Ig lambda chain V-VI region NIG-48 ProteinP01722 (Uniprot-TrEMBL)
Ig lambda chain V-VI region SUT ProteinP06317 (Uniprot-TrEMBL)
Ig lambda chain V-VI region WLT ProteinP06318 (Uniprot-TrEMBL)
Ig lambda chain V-VII region MOT ProteinP01720 (Uniprot-TrEMBL)
IgG-Ag:FCGRIA:CD3G homodimerComplexR-HSA-2029132 (Reactome)
IgG-Ag:FCGRIIAComplexR-HSA-1861689 (Reactome)
IgG-Ag:FCGRIIIA:CD3G/CD3Z dimersComplexR-HSA-2029163 (Reactome)
IgH heavy chain V-III region VH26 precursor ProteinP01764 (Uniprot-TrEMBL)
LIMK1ProteinP53667 (Uniprot-TrEMBL)
LYN ProteinP07948 (Uniprot-TrEMBL)
MYH2 ProteinQ9UKX2 (Uniprot-TrEMBL)
MYH9 ProteinP35579 (Uniprot-TrEMBL)
MYO10 ProteinQ9HD67 (Uniprot-TrEMBL)
MYO1C ProteinO00159 (Uniprot-TrEMBL)
MYO5A ProteinQ9Y4I1 (Uniprot-TrEMBL)
MYO9B ProteinQ13459 (Uniprot-TrEMBL)
Mother filament:ARP2/3:actin:GDPComplexR-HSA-2197686 (Reactome)
Mother

filament:branching complex:daughter

filament		ComplexR-HSA-1861699 (Reactome)
Mother

filament:branching

complex		ComplexR-HSA-2029140 (Reactome)
Myosin-Actin filamentsComplexR-HSA-2029139 (Reactome)
Myosin-X dimerComplexR-HSA-1861665 (Reactome)
MyosinComplexR-HSA-2029109 (Reactome)
N-WASP ProteinO00401 (Uniprot-TrEMBL)
NAD+ MetaboliteCHEBI:15846 (ChEBI)
NCK1 ProteinP16333 (Uniprot-TrEMBL)
NCKAP1 ProteinQ9Y2A7 (Uniprot-TrEMBL)
NCKAP1L ProteinP55160 (Uniprot-TrEMBL)
NCKIPSD ProteinQ9NZQ3 (Uniprot-TrEMBL)
PAMetaboliteCHEBI:16337 (ChEBI)
PAK1 ProteinQ13153 (Uniprot-TrEMBL)
PAK1 dimerComplexR-HSA-445002 (Reactome)
PAK1ProteinQ13153 (Uniprot-TrEMBL)
PCMetaboliteCHEBI:16110 (ChEBI)
PI(3,4)P2 MetaboliteCHEBI:16152 (ChEBI)
PI(3,4)P2MetaboliteCHEBI:16152 (ChEBI)
PI(3,4,5)P3 MetaboliteCHEBI:16618 (ChEBI)
PI(3,4,5)P3MetaboliteCHEBI:16618 (ChEBI)
PI(4,5)P2 MetaboliteCHEBI:18348 (ChEBI)
PI(4,5)P2MetaboliteCHEBI:18348 (ChEBI)
PI3K:p-6Y-SYKComplexR-HSA-2029149 (Reactome)
PI3KComplexR-HSA-74693 (Reactome)
PIK3CA ProteinP42336 (Uniprot-TrEMBL)
PIK3CB ProteinP42338 (Uniprot-TrEMBL)
PIK3R1 ProteinP27986 (Uniprot-TrEMBL)
PIK3R2 ProteinO00459 (Uniprot-TrEMBL)
PKC-delta/epsilonComplexR-HSA-198276 (Reactome)
PLA2G6ProteinO60733 (Uniprot-TrEMBL)
PLC gamma1,2ComplexR-HSA-1169089 (Reactome)
PLCG1 ProteinP19174 (Uniprot-TrEMBL)
PLCG2 ProteinP16885 (Uniprot-TrEMBL)
PLD1 ProteinQ13393 (Uniprot-TrEMBL)
PLD2 ProteinO14939 (Uniprot-TrEMBL)
PLD3 ProteinQ8IV08 (Uniprot-TrEMBL)
PLD4 ProteinQ96BZ4 (Uniprot-TrEMBL)
PLDComplexR-HSA-2029102 (Reactome)
PPAPDC1A ProteinQ5VZY2 (Uniprot-TrEMBL)
PPAPDC1B ProteinQ8NEB5 (Uniprot-TrEMBL)
PRKCD ProteinQ05655 (Uniprot-TrEMBL)
PRKCE ProteinQ02156 (Uniprot-TrEMBL)
Phosphatidate phosphataseComplexR-HSA-2029101 (Reactome)
Phospho-PKC-delta/epsilonComplexR-HSA-198265 (Reactome)
PiMetaboliteCHEBI:18367 (ChEBI)
RAC1 ProteinP63000 (Uniprot-TrEMBL)
RAC1/CDC42:PAK dimerComplexR-HSA-2029159 (Reactome)
RAC1/CDC42:p-S144,T423-PAKComplexR-HSA-2029155 (Reactome)
RAC1:GDPComplexR-HSA-5674631 (Reactome)
RAC1:GTPComplexR-HSA-442641 (Reactome)
SH3 domain proteinsComplexR-HSA-2197679 (Reactome)
SRC-1 ProteinP12931-1 (Uniprot-TrEMBL)
SYK ProteinP43405 (Uniprot-TrEMBL)
SYKProteinP43405 (Uniprot-TrEMBL)
Src family kinases (SFKs)ComplexR-HSA-1861597 (Reactome)
Src-kinasesComplexR-HSA-2197681 (Reactome)
VAV1 ProteinP15498 (Uniprot-TrEMBL)
VAV1,2,3ComplexR-HSA-430172 (Reactome)
VAV2 ProteinP52735 (Uniprot-TrEMBL)
VAV3 ProteinQ9UKW4 (Uniprot-TrEMBL)
WAS ProteinP42768 (Uniprot-TrEMBL)
WASF1 ProteinQ92558 (Uniprot-TrEMBL)
WASF2 ProteinQ9Y6W5 (Uniprot-TrEMBL)
WASF3 ProteinQ9UPY6 (Uniprot-TrEMBL)
WASP/N-WASPComplexR-HSA-201892 (Reactome)
WAVE Regulatory ComplexComplexR-HSA-2029154 (Reactome)
WIP family proteinsComplexR-HSA-2197678 (Reactome)
WIPF1 ProteinO43516 (Uniprot-TrEMBL)
WIPF2 ProteinQ8TF74 (Uniprot-TrEMBL)
WIPF3 ProteinA6NGB9 (Uniprot-TrEMBL)
WRC:IRSp53/58:RAC1:GTP:PIP3ComplexR-HSA-2029147 (Reactome)
YES1 ProteinP07947 (Uniprot-TrEMBL)
clustered IgG-Ag:FCGRsComplexR-HSA-2029146 (Reactome)
clustered IgG-Ag:p-FCGRs:SYKComplexR-HSA-2029129 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCGComplexR-HSA-2029137 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAVComplexR-HSA-2029133 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCGComplexR-HSA-2029156 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-VAVComplexR-HSA-2029131 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYKComplexR-HSA-2029158 (Reactome)
clustered IgG-Ag:p-FCGRsComplexR-HSA-2029128 (Reactome)
clustered IgG-Ag:p-FCGRsComplexR-HSA-2029151 (Reactome)
p-4S-ABI2 ProteinQ9NYB9 (Uniprot-TrEMBL)
p-4Y-PLCG1 ProteinP19174 (Uniprot-TrEMBL)
p-4Y-PLCG1ProteinP19174 (Uniprot-TrEMBL)
p-5S-ABI1 ProteinQ8IZP0 (Uniprot-TrEMBL)
p-6Y-CD247-1 ProteinP20963-1 (Uniprot-TrEMBL)
p-6Y-SYK ProteinP43405 (Uniprot-TrEMBL)
p-PLCGComplexR-HSA-2029095 (Reactome)
p-S,T508-LIMK1 ProteinP53667 (Uniprot-TrEMBL)
p-S144,T423-PAK1 ProteinQ13153 (Uniprot-TrEMBL)
p-S144,T423-PAK1ProteinQ13153 (Uniprot-TrEMBL)
p-S3-CFL1 ProteinP23528 (Uniprot-TrEMBL)
p-T,Y MAPK dimersComplexR-HSA-1268261 (Reactome)
p-T185,Y187-MAPK1 ProteinP28482 (Uniprot-TrEMBL)
p-T202,Y204-MAPK3 ProteinP27361 (Uniprot-TrEMBL)
p-T507,S645,S664-PRKCD(1-676) ProteinQ05655 (Uniprot-TrEMBL)
p-T508-LIMK1 ProteinP53667 (Uniprot-TrEMBL)
p-T508-LIMK1ProteinP53667 (Uniprot-TrEMBL)
p-T566,T710,S729-PRKCE ProteinQ02156 (Uniprot-TrEMBL)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3ComplexR-HSA-2029148 (Reactome)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3ComplexR-HSA-2130182 (Reactome)
p-Y150,S343,T346-WASF2 ProteinQ9Y6W5 (Uniprot-TrEMBL)
p-Y150-WASF2 ProteinQ9Y6W5 (Uniprot-TrEMBL)
p-Y151,S,T-WASF1 ProteinQ92558 (Uniprot-TrEMBL)
p-Y151,S,T-WASF3 ProteinQ9UPY6 (Uniprot-TrEMBL)
p-Y151-WASF1 ProteinQ92558 (Uniprot-TrEMBL)
p-Y151-WASF3 ProteinQ9UPY6 (Uniprot-TrEMBL)
p-Y160,Y171-CD3G ProteinP09693 (Uniprot-TrEMBL)
p-Y172-VAV2 ProteinP52735 (Uniprot-TrEMBL)
p-Y173-VAV3 ProteinQ9UKW4 (Uniprot-TrEMBL)
p-Y174-VAV1 ProteinP15498 (Uniprot-TrEMBL)
p-Y256-WASL ProteinO00401 (Uniprot-TrEMBL)
p-Y288,Y304-FCGR2A ProteinP12318 (Uniprot-TrEMBL)
p-Y291-WAS ProteinP42768 (Uniprot-TrEMBL)
p-Y753,Y759,Y1217-PLCG2 ProteinP16885 (Uniprot-TrEMBL)
pCofilin: Active LIMK-1ComplexR-HSA-399878 (Reactome)
pLIMK dimer:HSP-90ComplexR-HSA-419632 (Reactome)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
2-LysophosphatidylcholineArrowR-HSA-2029475 (Reactome)
ABL1mim-catalysisR-HSA-2130194 (Reactome)
ADPArrowR-HSA-198314 (Reactome)
ADPArrowR-HSA-2029268 (Reactome)
ADPArrowR-HSA-2029271 (Reactome)
ADPArrowR-HSA-2029449 (Reactome)
ADPArrowR-HSA-2029453 (Reactome)
ADPArrowR-HSA-2029454 (Reactome)
ADPArrowR-HSA-2029459 (Reactome)
ADPArrowR-HSA-2029460 (Reactome)
ADPArrowR-HSA-2029469 (Reactome)
ADPArrowR-HSA-2130194 (Reactome)
ADPArrowR-HSA-2197698 (Reactome)
ADPArrowR-HSA-399950 (Reactome)
ADPArrowR-HSA-419644 (Reactome)
AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramerTBarR-HSA-169683 (Reactome)
ARAArrowR-HSA-2029475 (Reactome)
ARP2/3 complex (ATP bound)R-HSA-442592 (Reactome)
ATPR-HSA-1861595 (Reactome)
ATPR-HSA-198314 (Reactome)
ATPR-HSA-2029268 (Reactome)
ATPR-HSA-2029271 (Reactome)
ATPR-HSA-2029449 (Reactome)
ATPR-HSA-2029453 (Reactome)
ATPR-HSA-2029454 (Reactome)
ATPR-HSA-2029459 (Reactome)
ATPR-HSA-2029460 (Reactome)
ATPR-HSA-2029469 (Reactome)
ATPR-HSA-2029476 (Reactome)
ATPR-HSA-2130194 (Reactome)
ATPR-HSA-2197698 (Reactome)
ATPR-HSA-399950 (Reactome)
ATPR-HSA-419644 (Reactome)
Actin filament bound Myosin-XArrowR-HSA-1861595 (Reactome)
Actin:ADPArrowR-HSA-2029473 (Reactome)
Activated WAVE2 and

WASP/N-WASP:ARP2/3

complex:G-actin		ArrowR-HSA-442592 (Reactome)
Activated WAVE2 and

WASP/N-WASP:ARP2/3

complex:G-actin		R-HSA-2029466 (Reactome)
Activated WAVE2 and WASP/N-WASPArrowR-HSA-2197690 (Reactome)
Activated WAVE2 and WASP/N-WASPR-HSA-442592 (Reactome)
Active LIMK1ArrowR-HSA-419644 (Reactome)
Active LIMK1R-HSA-399950 (Reactome)
Active LIMK1mim-catalysisR-HSA-399950 (Reactome)
Antigen-antibody complexR-HSA-1861621 (Reactome)
Antigen-antibody complexR-HSA-2029455 (Reactome)
Antigen-antibody complexR-HSA-2029457 (Reactome)
BAIAP2R-HSA-2029465 (Reactome)
CDC42:GDPR-HSA-2029445 (Reactome)
CDC42:GTP, RAC1:GTPR-HSA-2029456 (Reactome)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteinsArrowR-HSA-2197691 (Reactome)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteinsR-HSA-2197698 (Reactome)
CDC42:GTP:WASP/N-WASPArrowR-HSA-442586 (Reactome)
CDC42:GTP:WASP/N-WASPR-HSA-2197691 (Reactome)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteinsArrowR-HSA-2197698 (Reactome)
CDC42:GTPArrowR-HSA-2029445 (Reactome)
CDC42:GTPR-HSA-442586 (Reactome)
CFL1R-HSA-399950 (Reactome)
CRK:DOCK180:ELMO1,ELMO2R-HSA-2197697 (Reactome)
CRKII:DOCK180:ELMO

complex recruited

to phagocytic cup		ArrowR-HSA-2197697 (Reactome)
CRKII:DOCK180:ELMO

complex recruited

to phagocytic cup		mim-catalysisR-HSA-2029467 (Reactome)
Ca2+ArrowR-HSA-169683 (Reactome)
Ca2+R-HSA-169683 (Reactome)
ChoArrowR-HSA-2029471 (Reactome)
DAGsArrowR-HSA-167686 (Reactome)
DAGsArrowR-HSA-198314 (Reactome)
DAGsArrowR-HSA-2029468 (Reactome)
F-actinR-HSA-2029466 (Reactome)
FCGR2AR-HSA-1861621 (Reactome)
FCGRIA:CD3G homodimerR-HSA-2029455 (Reactome)
FCGRIIIA:CD3G/CD3Z dimersR-HSA-2029457 (Reactome)
G-actinR-HSA-2029473 (Reactome)
G-actinR-HSA-442592 (Reactome)
GDPArrowR-HSA-2029445 (Reactome)
GDPArrowR-HSA-2029451 (Reactome)
GDPArrowR-HSA-2029467 (Reactome)
GTPR-HSA-2029445 (Reactome)
GTPR-HSA-2029451 (Reactome)
GTPR-HSA-2029467 (Reactome)
H2OR-HSA-167686 (Reactome)
H2OR-HSA-2029468 (Reactome)
H2OR-HSA-2029471 (Reactome)
H2OR-HSA-2029475 (Reactome)
HSP90AA1,HSP90AB1ArrowR-HSA-419644 (Reactome)
HSP90AA1,HSP90AB1R-HSA-419645 (Reactome)
I(1,4,5)P3ArrowR-HSA-167686 (Reactome)
I(1,4,5)P3ArrowR-HSA-169683 (Reactome)
I(1,4,5)P3R-HSA-169680 (Reactome)
IP3 receptor homotetramerR-HSA-169680 (Reactome)
ITPR:I(1,4,5)P3 tetramerArrowR-HSA-169680 (Reactome)
ITPR:I(1,4,5)P3 tetramermim-catalysisR-HSA-169683 (Reactome)
IgG-Ag:FCGRIA:CD3G homodimerArrowR-HSA-2029455 (Reactome)
IgG-Ag:FCGRIIAArrowR-HSA-1861621 (Reactome)
IgG-Ag:FCGRIIIA:CD3G/CD3Z dimersArrowR-HSA-2029457 (Reactome)
LIMK1R-HSA-2029460 (Reactome)
Mother filament:ARP2/3:actin:GDPArrowR-HSA-2197690 (Reactome)
Mother filament:ARP2/3:actin:GDPR-HSA-2029473 (Reactome)
Mother

filament:branching complex:daughter

filament		ArrowR-HSA-2029473 (Reactome)
Mother

filament:branching complex:daughter

filament		R-HSA-1861595 (Reactome)
Mother

filament:branching complex:daughter

filament		R-HSA-2029476 (Reactome)
Mother

filament:branching

complex		ArrowR-HSA-2029466 (Reactome)
Mother

filament:branching

complex		R-HSA-2197690 (Reactome)
Myosin-Actin filamentsArrowR-HSA-2029476 (Reactome)
Myosin-X dimerR-HSA-1861595 (Reactome)
Myosin-X dimermim-catalysisR-HSA-1861595 (Reactome)
MyosinR-HSA-2029476 (Reactome)
PAArrowR-HSA-2029471 (Reactome)
PAK1 dimerR-HSA-2029456 (Reactome)
PAK1mim-catalysisR-HSA-2029454 (Reactome)
PAR-HSA-2029468 (Reactome)
PCR-HSA-2029471 (Reactome)
PCR-HSA-2029475 (Reactome)
PI(3,4)P2R-HSA-1861595 (Reactome)
PI(3,4,5)P3ArrowR-HSA-2029271 (Reactome)
PI(3,4,5)P3ArrowR-HSA-2029272 (Reactome)
PI(3,4,5)P3R-HSA-2029268 (Reactome)
PI(3,4,5)P3R-HSA-2029458 (Reactome)
PI(3,4,5)P3R-HSA-2029465 (Reactome)
PI(4,5)P2R-HSA-167686 (Reactome)
PI(4,5)P2R-HSA-2029271 (Reactome)
PI(4,5)P2R-HSA-442586 (Reactome)
PI3K:p-6Y-SYKArrowR-HSA-2029273 (Reactome)
PI3K:p-6Y-SYKmim-catalysisR-HSA-2029271 (Reactome)
PI3KR-HSA-2029273 (Reactome)
PKC-delta/epsilonR-HSA-198314 (Reactome)
PKC-delta/epsilonmim-catalysisR-HSA-198314 (Reactome)
PLA2G6mim-catalysisR-HSA-2029475 (Reactome)
PLC gamma1,2R-HSA-2029270 (Reactome)
PLDmim-catalysisR-HSA-2029471 (Reactome)
Phosphatidate phosphatasemim-catalysisR-HSA-2029468 (Reactome)
Phospho-PKC-delta/epsilonArrowR-HSA-198314 (Reactome)
PiArrowR-HSA-1861595 (Reactome)
PiArrowR-HSA-2029468 (Reactome)
PiArrowR-HSA-2029473 (Reactome)
PiArrowR-HSA-2029476 (Reactome)
R-HSA-167686 (Reactome) Inositol 1,4,5-triphosphate (IP3) is a second messenger produced by phospholipase C (PLC) metabolism of phosphoinositol 4,5-bisphosphate (PIP2) (Canossa et al. 2001).
R-HSA-169680 (Reactome) The IP3 receptor (IP3R) is an IP3-gated calcium channel. It is a large, homotetrameric protein, similar to other calcium channel proteins such as ryanodine. The four subunits form a 'four-leafed clover' structure arranged around the central calcium channel. Binding of ligands such as IP3 results in conformational changes in the receptor's structure that leads to channel opening.
R-HSA-169683 (Reactome) IP3 promotes the release of intracellular calcium.
R-HSA-1861595 (Reactome) Myosin-X (Myosin 10) is one of the downstream effectors of PI3K in FCGR-phagocytosis and is involved in pseudopod extension and closure of phagocytic cups. It is recruited to the forming phagosome by binding, through its second PH domain to membrane PIP3, a major product of PI3-kinase (Cox et al. 2002). Myosin-X may act as a motor to transport membrane cargo molecules to the forming pseudopods, influencing actin dynamics. It is not understood with certainty how myosin X contributes to the mechanism of pseudopod extension. It selectively binds to actin bundle such that each head may bind, in an ATP-sensitive manner, to two adjacent actin filaments within the actin bundle. Myosin X hydrolyze ATP and converts this chemical energy to mechanical energy moving toward the plus end/barbed end of the actin filament facing towards the tip of the growing pseudopods (Araki 2006, Chavrier 2003, Watanabe et al 2010).
R-HSA-1861621 (Reactome) FCGRII (CD32) is a low-affinity receptor encoded by three different genes (A, B and C) (Brooks et al. 1989). FCGRIIA functions as a single-chain transmembrane receptor containing both the ligand-binding extracellular domain and a signal transducing cytoplasmic domain that contains distinct immunoreceptor tyrosine-based activation motif (ITAM). This ITAM-like domain in FCGRIIA contains two YXXL motifs with a spacer sequence of 12 amino acids instead of the usual 7. Isoform FCGRIIB is expressed in various leukocytes, including human monocytes and, as opposed to the activating Fc receptors it has an immunoreceptor tyrosine-based inhibitory motif (ITIM) and negatively regulates phagocytosis (Van den Herik-Oudijk IE et al. 1995, Mitchell et al. 1994, Tridandapani et al. 2002).
The first step in Fc-gamma receptor (FCGR) phagocytosis is binding and clustering of FCGRs by IgG-coated foreign particles. FCGR are clustered at the cell surface by multivalent antigen-antibody complexes and recruited to lipid raft micro domains; monovalent ligand binding is insufficient to generate a signal. This cross-linking results in the localization of FCGRs into lipid rafts and this may aid in recruiting and complexing with additional signalling proteins associated with lipid rafts (Bournazos et al. 2009, Kwiatkowska & Sobota 2001, Kono et al. 2002). This is followed by phosphorylation of the tyrosine residues within the ITAM located on the cytoplasmic portion of FCGRIIA by membrane-associated tyrosine kinases of the Src family (Mitchell et al. 1994).
R-HSA-198314 (Reactome) Diacylglycerol (DAG) positively regulates the autophosphorylation of protein kinase C-delta (PKC-delta), which stimulates ERK1/2 and triggers neurite outgrowth. DAG also stimulates the translocation of PKC from the cytosol to the plasma membrane. PKC-delta contributes to growth factor specificity and response to neuronal cells by promoting cell-type-specific differences in growth factor signalling. DAG can also activate PKC-epsilon in the same manner.
R-HSA-2029268 (Reactome) PLCG is tyrosine phosphorylated by either SYK or Src kinases on three tyrosine residues and this phosphorylation enhances the activity of PLCG. Although maximal activation requires binding of PLCG to PIP3 with its plecstrin homology (PH) domain.
R-HSA-2029270 (Reactome) PLCgamma (PLCG) is recruited to FCGR and the phosphorylated Y342 and Y346 in SYK have been reported to be involved in the interaction of PLCG (Law et al. 1996). PLCG accumulates at the phagocytic cup during FCGR, but the exact role of PLCG in the regulation of phagocytosis is not clear. It may be involved in FCGR signaling by activating PKC through DAG production (Garcia-Garcia & Rosales 2002 )
R-HSA-2029271 (Reactome) Activated PI3K phosphorylates phosphatidylinositol (PI) 4-phosphate and PI 4,5-bisphosphate (PIP2) to generate PI 3,4-bisphosphate and PI 3,4,5-triphosphate (PIP3) and these second messengers recruit other signaling proteins containing plecstrin homology (PH) domain. PIP3 rapidly accumulates at sites of phagocytosis and disappears after the phagosome has been sealed off from the plasma membrane.
R-HSA-2029272 (Reactome) Activated PLCG translocates to the plasmamembrane and interacts with the inositol ring of the membrane bound phosphatidylinositol 4,5-bisphosphate (PIP2) with its PH domain. The active enzyme promotes intracelllular signaling by catalysing the hydrolysis of PIP2 to generate the second messengers IP3 and DAG.
R-HSA-2029273 (Reactome) PI3K is one of the downstream effector of activated SYK. The p85 alpha regulatory subunit of PI3K have been shown to interact with SYK and FCGRs, and transient and restricted accumulation of lipid products of the kinase have been observed at sites of the phagosomal cup (Yanagi et al. 1994, Marshall et al. 2001). Leverrier at al. has demonstrated that p110beta is the major class I catalytic isoform required for FCGR-mediated phagocytosis by primary macrophages (Leverrier at al. 2003). p85 alpha subunit interacts with phosphorylated SYK at tyrosine 317 with its C-terminal SH2 domain, whereas other tyrosine residues like 342 and 346 in the linker region may contribute to the interaction with N-terminal SH2 domain (Moon et al, 2005). The main role of PI3K in phagocytosis appears to be the regulation of pseudopod extension necessary for particle internalization and may also regulate phagocytosis through activation of ERK (Garcia-Garcia & Rosales. 2002).
R-HSA-2029445 (Reactome) FCGR mediated phagocytosis requires CDC42 to stimulate actin polymerization, generating the force for phagocytic cup protrusion or pseudopod extension. CDC42 activation is restricted at the advancing edge of the phagocytic cup, where actin is concentrated, and is deactivated at the base of the phagocytic cup (Beemiller et al 2010). The mechanism behind the recruitment and activation of CDC42 during FCGR phagocytosis is unknown. VAV regulates the activation of RAC1 but not CDC42 and the GEF responsible for CDC42 activation during FCGR-mediated phagocytosis remains unidentified (Adam et al 2004, Patel et al 2002).
R-HSA-2029449 (Reactome) Multiple sites of phosphorylation are known to exist in SYK, which both regulate its activity and also serve as docking sites for other proteins. Some of these sites include Y131 of interdomain A, Y323, Y348, and Y352 of interdomain B, and Y525 and Y526 within the activation loop of the kinase domain and Y630 in the C-terminus (Zhang et al. 2002, Lupher et al. 1998, Furlong et al. 1997). Phosphorylation of these tyrosine residues disrupts autoinhibitory interactions and results in kinase activation even in the absence of phosphorylated ITAM tyrosines (Tsang et al. 2008). SYK is primarily phosphorylated by Src family kinases and this acts as an initiating trigger by generating few molecules of activated SYK which are then involved in major SYK autophosphorylation (Hillal et al. 1997).
R-HSA-2029451 (Reactome) The organized movements of membranes and the actin cytoskeleton are coordinated in phagocytosis by small GTPases of the Rho family. Specifically, RAC1 and CDC42 are known to be stimulated upon engagement of FCGR and are essential for the extension of the pseudopods that surround and engulf the phagocytic particle (Scott et al 2005). RAC1 is known to regulate actin dynamics. It is active throughout the phagocytic cup and activated RAC1 is necessary to assemble F actin. However, closing the phagocytic cup requires RAC1 to be deactivated (Naakaya et al 2007). Deletion of RAC1 prevents FCGR mediated phagocytosis (Hall et al 2006). RAC1 activation involves transition from an inactive GDP bound to an active GTP bound state catalysed by guanine exchanges factors (GEFs). VAV has been implicated in the activation of RAC1 (Patel et al 2002).
R-HSA-2029452 (Reactome) SYK is a tyrosine kinase related to ZAP70 that is expressed in all hematopoietic cells and coimmunoprecipitates with the gamma chain associated with FCGRIIIA in macrophages and with FCERI in mast cells. SYK is very important for FCGR phagocytosis and is recruited to these phosphorylated ITAM residues through its two SRC homology 2 (SH2) domains (Agarwal et al. 1993). When SYK kinase expression is inhibited with antisense oligonucleotides both in vitro and in vivo, phagocytosis and inflammation are abolished (Matsuda et al. 1997). The domain structure of SYK comprises a regulatory region at the N-terminus consisting of a pair of SH2 domains separated by an inter-SH2 linker called interdomain A, an SH2-domain-kinase linker termed interdomain B, and a C-terminal kinase domain (Arias-Palomo et al. 2009). In resting state SYK exists in an auto-inhibited conformation by the interactions between the SH2-SH2 regulatory region and the inter-SH2 linker and the catalytic domain. This interdomain interaction reduces the conformational flexibility required by the kinase domain for catalysis (Arias-Palomo et al. 2007). Changes in the orientation of the SH2 domains could control the disruption of the auto inhibitory interactions and the activation of SYK. These movements could be totally or partially induced by the binding to phosphorylated ITAMs and/or phosphorylation of tyrosine residues in interdomain A or B (Arias-Palomo et al. 2009). Tsang et al. suggested that SYK functions as an OR-gate switch with respect to phosphorylation and ITAM binding, as either one stimulus OR the other is sufficient to cause full activation (Tsang et al. 2008).
R-HSA-2029453 (Reactome) VAV proteins exist in an auto-inhibitory state folded in such a way as to inhibit the GEF activity of its DH domain. This folding is mediated through binding of tyrosines in the acidic domain to the DH domain and through binding of the CH domain to the C1 region. Activation of VAV may involve at least three different events to relieve this auto-inhibition. Phosphorylation of the tyrosines in the acidic domain causes them to be displaced from the DH domain, binding of a ligand to the CH domain may cause it to release the C1 domain and binding of PIP3 to PH domain may alter its conformation. VAV1 is phosphorylated on Y174 in the acidic domain, and this is mediated by Syk and Src-family tyrosine kinases. Once activated, VAV1 is then involved in the activation of RAC and CDC42 downstream of FCGR.
R-HSA-2029454 (Reactome) PAK1 needs autophosphorylation for complete activation. PAK1 is autophosphorylated at several sites, but S144 flanking the kinase inhibitor region and T423 within the catalytic domain are the two conserved sites that regulate the catalytic activity (Chong et al. 2001, Parrini et al. 2001).
R-HSA-2029455 (Reactome) FCGRI is coded by three different genes (A, B, and C) and is expressed on most myeloid cells including monocytes, macrophages and dendritic cells (Allen & Seed 1988). FCGRI is a high affinity IgG receptor capable of binding monomeric IgG. FCGRI exists as a complex containing ligand (IgG) binding extracellular alpha-chain and homodimer of signal transducing FcR gamma (CD3G) chains, or a heterodimer of signal transducing FcR gamma and zeta chains (Ernst et al. 1993, Scholl & Geha 1993, van Vugt et al. 1996). The cytoplasmic domain of FCGRI does not have signaling motifs, however it is suggested that the gamma-subunit might be required for generating the phagocytic signal (Duchemin et al. 1994, Indik et al. 1995).
The first step in Fc-gamma receptor (FCGR) phagocytosis is binding and clustering of FCGRs by IgG-coated foreign particles. FCGR are clustered at the cell surface by multivalent antigen-antibody complexes and recruited to lipid raft micro domains; monovalent ligand binding is insufficient to generate a signal. This cross-linking results in the localization of FCGRs into lipid rafts and this may aid in recruiting and complexing with additional signalling proteins associated with lipid rafts (Bournazos et al. 2009, Kwiatkowska & Sobota 2001, Kono et al. 2002). This is followed by phosphorylation of the tyrosine residues with in the immuno tyrosine activation motif (ITAM) located on the cytoplasmic portion of accessory gamma/zeta chains by membrane-associated tyrosine kinases of the Src family (Duchemin et al. 1994, van Vugt et al. 1996).
R-HSA-2029456 (Reactome) PAK1, a downstream effector of CDC42 and RAC1, is found localized in phagosomes. Upon activation, PAK1 phosphorylates LIMK, which directly phosphorylates and inactivates cofilin, a protein that mediates depolymerization of actin filaments. Thus, RAC and CDC42 coordinate actin dynamics by inducing actin polymerization via ARP2/3 on one hand, and inhibiting actin depolyerization via LIMK and cofilin on the other (Garcia-Garcia & Rosales 2002).
PAK1 exists as homodimer in a trans-inhibited conformation. The kinase inhibitory (KI) domain of one PAK1 molecule binds to the C-terminal catalytic domain of the other and inhibits catalytic activity. GTPases RAC1/CDC42 bind the GBD domain of PAK1 thereby altering the conformation of the KI domain, relieving inhibition of its catalytic domain, and allowing PAK1 autophosphorylation that is required for full kinase activity (Parrini et al. 2002, Zhao & Manser 2005).
R-HSA-2029457 (Reactome) FCGRIII (CD16) is a low affinity Fc gamma receptor and is encoded by two genes (A and B), the transmembrane form FCGRIIIA and the GPI anchored FCGRIIIB (Edberg et al. 1989). Between the two isoforms FCGRIIIA is involved in phagocytosis whereas FCGRIIIB is capable of inducing calcium signalling and actin polymerisation, but its role in phagocytosis is still not clear (Garcia Garcia & Rosales 2002). FCGRIIIA is expressed in macrophages and natural killer cells as a multi chain complex consisting of a single alpha chain containing IgG binding domains and a signal transducing gamma and/or zeta dimer (Wirthmuller et al. 1992, Lanier et al. 1989). Both gamma and zeta chains contain a conserved immunoreceptor tyrosine based activation motif (ITAM), which has 2 copies of the YXXL sequence (Isakov 1997). However, the gamma chain of FCGRIIIA is approximately sixfold more efficient in mediating phagocytosis than the zeta subunit (Park & Schreiber 1995). Phosphorylation of the conserved tyrosine residues of the ITAM in these accessory proteins is required for the phagocytic signal mediated by FCRGIIIA.
The first step in Fc-gamma receptor (FCGR) phagocytosis is binding and clustering of FCGRs by IgG-coated foreign particles. FCGR are clustered at the cell surface by multivalent antigen-antibody complexes and recruited to lipid raft micro domains; monovalent ligand binding is insufficient to generate a signal.
This cross linking results in the localisation of FCGRs into lipid rafts and this may aid in their recruiting and complexing with additional signalling proteins associated with lipid rafts (Kono et al. 2002). This is followed by phosphorylation of the tyrosine residues within the ITAM located on the cytoplasmic portion of accessory gamma/zeta chains by membrane associated tyrosine kinases of the Src family (Park et al. 1993).
R-HSA-2029458 (Reactome) VAV family members are cytoplasmic guanine nucleotide exchange factors (GEFs) for Rho-family GTPases (RAC, RHO and CDC42). VAV1 is found predominantly in hematopoietic cells, whereas VAV2 and VAV3 are more broadly expressed. VAV proteins link the cell surface receptors like FCGR to the intracellular Rho GTPases and the actin cytoskeleton during phagocytosis (Hall et al 2006). Experiments using two-hybrid system suggest that VAV1 with its SH2 domain directly binds to the phosphorylated Y342 of SYK (Deckert et al. 1996). VAV proteins are also recruited to membrane through their PH domain by binding PI(3,4,5)P3 produced by PI3K.
R-HSA-2029459 (Reactome) After cross linking, Fc gamma receptors are sequestered to lipid rafts where they are complexed with some of the tyrosine kinases of Src family and undergo phosphorylation on the tyrosine residues contained in conserved ITAM sequences. At least six out of nine members of the Src family kinases (SRC, FYN, FGR, HCK, YES and LYN ) have been identified in the phagocytic cells and are implicated in the initiation of Fc gamma mediated signaling. (Suzuki et al. 2000, Majeed et al. 2001, Kwiatkowska et al. 2003). Some of these kinases have been found associated with specific receptors. In monocytes HCK and LYN have been found associated with FCGRI (Durden et al. 1995), whereas only HCK with FCGRIIA (Ghazizadeh et al. 1994) while FGR in neutrophils (Hamada et al. 1993) and LCK in NK cells with FCGRIIIA (Pignata et al. 1993)
The implication of Src kinases in phosphorylation was first supported by pharmacological findings that herbimycin A, a tyrosine kinase inhibitor relatively specific for Src-family kinases, potently suppressed Fc receptor mediated functions (Greenberg et al. 1993, Suzuki et al. 2000). However, their particular involvement in phagocytosis remains unclear, as targeted disruption of single or multiple Src family genes did not result in significant alterations in phagocytosis (Hunter et al. 1993, Fitzer Attas et al. 2000, Suzuki et al. 2000). HCK, FGR and LYN triple-deficient (-/-) macrophages have shown significant delays in FCGR mediated phagocytosis, but these deficiencies do not completly disrupt the process (Fitzer Attas et al. 2000).
Tyrosine residues Y288 and Y304 (Y282 and Y298 according to the literature reference, it is 6 residues shorter compared to uniprot entry due to an alternate initiation codon usage), within ITAM sequence in the cytoplasmic domain of FCGRIIA are the key target sites that are phosphorylated by Src family kinases (Mitchell et al, 1994). In case of FCGRIA and FCGRIIIA the specific tyrosine residues within ITAMs of the associated gamma/zeta chains are phosphorylated by activated Src family kinases (SFKs) (Park et al. 1993).
R-HSA-2029460 (Reactome) LIM kinases are serine protein kinases with a unique combination of two N-terminal LIM motifs, a central PDZ domain, and a C-terminal protein kinase domain. LIMK1 is one of the downstream targets of PAK1 and is activated through phosphorylation by PAK1 on T508 within its activation loop (Edwards et al. 1999, Aizawa et al. 2001). LIM-kinase is responsible for the tight regulation of the activity of cofilin (a protein that depolymerizes actin filaments) and thus maintains the balance between actin assembly and disassembly. Phosphorylated cofilin is inactive, resulting in stabilization of the actin cytoskeleton.
R-HSA-2029465 (Reactome) WASP family verprolin-homologous proteins (WAVEs) function downstream of RAC1 and are involved in activation of the ARP2/3 complex. The resulting actin polymerization mediates the projection of the plasma membrane in lamellipodia and membrane ruffles. WAVEs exist as a pentameric hetero-complex called WAVE Regulatory Complex (WRC). The WRC consists of a WAVE family protein (WASF1, WASF2 or WASF3 - commonly known as WAVE1, WAVE2 or WAVE3), ABI (Abelson-interacting protein), NCKAP1 (NAP1, p125NAP1), CYFIP1 (SRA1) or the closely related CYFIP2 (PIR121), and BRK1 (HSPC300, BRICK). Of the three structurally conserved WAVEs in mammals, the importance of WAVE2 in activation of the ARP2/3 complex and the consequent formation of branched actin filaments is best established. WAVEs in the WRC are intrinsically inactive and are stimulated by RAC1 GTPase and phosphatidylinositols (PIP3). The C-terminal VCA domain of WAVE2 (and likely WAVE1 and WAVE3) which can bind both the ARP2/3 complex and actin monomers (G-actin) is masked in the inactive state. After PIP3 binds to the polybasic region of WAVE2 (and likely WAVE1 and WAVE3) and RAC1:GTP binds to the CYFIP1 (or CYFIP2) subunit of the WRC, allosteric changes most likely occur which allow WAVEs to interact with the ARP2/3 complex. The interactions between WAVEs and RAC1 are indirect. BAIAP2/IRSp53, an insulin receptor substrate, acts as a linker, binding both activated RAC1 and the proline-rich region of WAVE2 (and likely WAVE1 and WAVE3) and forming a trimolecular complex. CYFIP1 (or CYFIP2) in the WAVE regulatory complex binds directly to RAC1:GTP and links it to WAVE2 (and likely WAVE1 and WAVE3) (Derivery et al. 2009, Yamazaki et al. 2006, Takenawa & Suetsugu 2007, Chen et al. 2010, Pollard 2007, Lebensohn & Kirschner 2009).
R-HSA-2029466 (Reactome) Once activated, the ARP2/3 complex nucleates new actin filaments that extend from the sides of pre-existing mother actin filaments at a 70-degree angle to form Y-branched networks (Firat-Karalar & Welch 2010). These branched actin filaments push the cell membrane forward to form a pseudopod. The ARP2/3 complex is composed of two Arps (actin-related proteins), ARP2 and ARP3, and five unique proteins ARPC1, ARPC2, ARPC3, ARPC4 and ARPC5 (Gournier et al. 2001). Both ARP2 and ARP3 subunits bind ATP. There are two proposed models to explain the process of actin nucleation by ARP2/3 complex: the barbed-end branching model and the dendritic nucleation/side branching model (Le Clainche & Carlier 2008).
In barbed-end branching model, the branching/ternary complex (G-actin-WASP/WAVE-Arp2/3 complex) binds to the barbed end of the mother filament. G-actin bound to VCA domain or one of the Arp subunits incorporates into the mother filament at the barbed end, thus positioning ARP2/3 complex to initiate the daughter branch on the side of the mother filament. ARP2/3 nucleates the formation of new actin filament branches, which elongate at the barbed ends (Le Clainche & Carlier 2008, Pantaloni et al 2000, Le Clainche et al. 2003, Egile et al. 2005). In side branching model, the branching complex binds to the side of the mother actin filament mimicking an actin nucleus and initiates a lateral branch (Le Clainche & Carlier 2008, Amann & Pollard 2001).
R-HSA-2029467 (Reactome) RAC1 is activated from inactive GDP-bound state to active GTP-bound form by the GEF activity of DOCK180:ELMO complex.
R-HSA-2029468 (Reactome) Phosphatidic acid phosphatase (PAP) bound to the plasma membrane catalyzes the dephosphorylation of phosphatidic acid (PA), yielding diacylglycerol (DAG) and inorganic phosphate. In humans, Diacylglycerol pyrophosphate (DPPL1 and DPPL2) perform this reaction.
R-HSA-2029469 (Reactome) The ARP2/3 complex shows higher affinity for the phosphorylated VCA domain of WAVE2 than for the unphosphorylated VCA domain. WAVE proteins can be phosphorylated by various kinases. Active ERK (Mitogen activated protein kinase 3) phosphorylates the WAVE regulatory complex (WRC) on multiple serine/threonine sites within the proline-rich domains (PRDs) of WAVE2 and ABI1. Phosphorylation of the PRDs would disrupt their interaction with SH3 and PLP binding domains, potentially altering WRC activation. ERK phosphorylates both S343 and T346 in WAVE2 and S183, S216, S225, S392, and S410 in ABI1. Cumulatively, the phosphorylation of both WAVE2 and ABI in the WAVE regulatory complex (WRC) contributes to the RAC-induced WRC conformational change that exposes the VCA domain, leading to binding and activation of ARP2/3 (Mendoza et al. 2011, Nakanishi et al. 2007). ERK phosphorylation sites in WAVE2 are not strictly conserved in WAVE1 and WAVE3 but, based on the amino acid sequence, other potential ERK phosphorylation sites exist.
R-HSA-2029471 (Reactome) Phospholipase D (PLD) catalyses the hydrolysis of the membrane phospholipid, phosphatidylcholine (PC) to generate choline and metabolically active phosphatidic acid (PA) (Lennartz 1999). Pharmacological inhibition studies show that PLD participates in FCGR-mediated phagocytosis (Kusner et al. 1996). There is an increase in the activity of PLD following the activation of phagocytosis via FCGR (Kusner et al. 1999). Following activation of FCGR, PLD translocates to the plasma membrane at the phagocytic cup and generate PA. This PA can be converted to DAG through the action of phosphatidic acid phosphatase-1 (PAP-1). Thus activation of PLD may be an additional pathway leading to PKC activation.
The two isoforms PLD1 and PLD2 are both shown to be essential for the formation of phagosome at different stages. PLD1 is localized on the endosomal/lysosomal compartment and PLD2 is localized at the plasma membrane. PLD2 may be linked to phagosome formation whereas PLD1 may be involved in the focal exocytosis at the plasma membrane and also in the maturation process (Carrotte et al. 2006).
R-HSA-2029473 (Reactome) ATP bound G-actin monomers are added to the fast growing barbed ends of both mother and daughter filaments and the polymerization of these filaments drives membrane protrusion. In the process of phagocytosis, pseudopodia extend around the antibody-bound particle to form the phagocytic cup. This elongation continues until the filament reaches steady state equilibrium with free G-actin monomers (Millard et al. 2004, Le Clainche et al. 2008).
R-HSA-2029475 (Reactome) Several members of phospholipase A (PLA) are involved in phagocytosis. Macrophages express three classes of PLA2: secreted Ca-dependent (sPLA2), cytosolic Ca-dependent (cPLA2) and cytosolic Ca-independent (iPLA2) of which iPLA2 is involved in FCGR mediated arachidonic acid (AA) production. Aggregation of FCGR triggers phosphorylation and membrane translocation of iPLA2. Protein kinase C (PKC), ERK and p38MAPK seems to regulate iPLA2 in monocytes, neutrophils and macrophages. Phosphorylated iPLA2 then mediates production of AA and lysoophospholipids from phosphatidylcholine. iPLA2 inhibitors (bromoenol lactone) block AA release and phagocytosis which can be restored upon addition of exogenous AA, suggesting a critical role for iPLA2 in FCGR phagocytosis (Lennartz et al. 1993, Tay & Melendez). Release of AA by activated iPLA2 changes the physical characteristic of the membrane which may facilitate pseudopod extension.
R-HSA-2029476 (Reactome) In addition to the membrane remodeling for pseudopod extension, particle internalization requires a contractility force pulling the forming phagosome into the cytoplasm. Myosin motor proteins are the actin-binding proteins, with ATPase activity move along actin fibers, and produce the driving force for phagosome formation and transport. Several myosin motors including myosins IC, II, V, IXb are involved in FCGR-mediated phagocytosis as force generators and actin-based transport motors (Swanson et al. 1999). Nonmuscle myosin II, is a motor protein known to generate intracellular contractile forces and tension by associating with F-actin. It has been observed to localize around forming phagosomes and suggested a role in phagocytic-cup squeezing during FCGR-mediated phagocytosis. Each myosin II motor protein exists as a complex consisting of two copies each of myosin II heavy chain (MHC), essential light chains (ELC), and myosin regulatory light chain (MRLC). Selective inhibition of myosin II by ML-7, a myosin light-chain kinase (MLCK) inhibitor, prevents phagocytic cup closure, but not pseudopod extension for the formation of phagocytic cups in FCGR-mediated phagocytosis (Grooves et al. 2008, Araki 2006). Tight ring of actin filaments within the elongating pseudopodia squeezes the deformable particles. In the classical zipper model for phagocytosis, the pseudopod extends over the IgG-coated particles, in which FCGRs in the phagocyte plasma membrane interact sequentially with Fc portions of IgG molecules zippering the membrane along the particle. This sequential IgG-FCGR binding might not occur by itself, but requires forced zipper closure, where myosin-II contractile activity may promote the binding between the FCGR and its ligands, to facilitate the efficient extension and subsequent closure of phagocytic cups (Araki 2006, ). Myosin IC mediates the purse-string-like contraction that closes phagosomes. Myosin-V has been implicated in membrane trafficking events (Swanson et al. 1999).
R-HSA-2130194 (Reactome) Abelson interactor-1 (ABL) tyrosine kinase phosphorylates the strictly conserved tyrosine 150 in WAVE2 (Y151 in WAVE1 and WAVE3) (Leng et al. 2003, Chen et al. 2010).
R-HSA-2197690 (Reactome) After incorporation at the branch, the actin bound to VCA domain of WASP/WAVE undergoes ATP hydrolysis and this destabilizes its interaction with WASP/WAVE. This dissociates the branched junction from the membrane-bound WASP/WAVE (Kovar 2006).
R-HSA-2197691 (Reactome) WASP interacting proteins (WIP) family includes WIPF1 (WIP), WIPF2 (WIRE,WICH) and WIPF3 (CR16, corticosteroids and regional expression-16). WIPs share a specific proline rich sequence that interacts with the WH1 domain of WASP and N-WASP (WASL). WIPs form heterocomplexes with WASPs and may contribute to the WASP protein stability (Aspenstrom 2002, Kato et al. 2002, Ho et al. 2001, Moreau et al. 2000).
SH3 domain containing adaptor proteins like GRB2 (Carlier et al. 2000), NCK (Rohatgi et al. 2001) and WISH (DIP/SPIN90) (Fukuoka et al. 2001) bind to the proline rich domain in WASPs and activate the ARP2/3 complex. By binding simultaneously to N-WASP and the ARP2/3 complex, GRB2 works synergistically with CDC42 in the activation of ARP2/3 complex-mediated actin assembly (Carlier et al. 2000).
R-HSA-2197697 (Reactome) Macrophages lacking all the three isoforms of VAV did not affect FCGR-mediated phagocytosis suggesting that RAC1 is regulated by GEFs other than VAV downstream of the FCGR (Hall et al 2006). DOCK180, a member of GEFs, is found to be involved in the activation of RAC1. DOCK180 associates with the adaptor protein CRKII and the complex is found to accumulate at the phagocytic cup. DOCK180 is recruited to the sites of phagocytosis by binding to SH3 domain of CRKII through its proline-rich motif (Hasegawa et al 1996). CRKII is likely recruited to the activated FCGR complex by binding phosphorylated ITAM tyrosines on the receptor or through other phosphotyrosines on ancillary proteins that are recruited to the receptor complex (Lee et al 2007). Unlike the usual GEFs, DOCK180 does not contain the conserved Dbl homology (DH) domain. Instead, it has a DHR-2 or DOCKER domain capable of loading RAC with GTP (Brugnera et al 2002). Binding of DOCK180 to RAC alone is insufficient for GTP loading, and a DOCK180-ELMO interaction is required. ELMO1, as well as ELMO2, form a complex with DOCK180 and they function together as a bipartite GEF to optimally activate RAC (Gumienny et al 2001, Brugnera et al 2002).
R-HSA-2197698 (Reactome) WASP is phosphorylated on Tyr291 (Cory et al. 2002) and N-WASP (WASL) on Tyr256 (Wu et al. 2004) by Src family of tyrosine kinases and this phosphorylation may release the autoinhibitory intramolecular interactions. The phosphorylation seems to be enhanced by the activation of CDC42. WASP phosphorylation and binding of CDC42 have a synergistic effect on the activation of the ARP2/3 complex (Takenawa & Suetsugu 2007). In N-WASP, the phosphorylation may reduce its nuclear translocation and may sustain it in its functional site in the cytoplasm (Wu et al. 2004).
R-HSA-399950 (Reactome) The EPHB2-FAK pathway partially promotes dendritic spine stability through LIMK-mediated cofilin (CFL1) phosphorylation (Shi et al. 2009). CFL1 is a member of the ADF (actin-depolymerizing factor) protein family that is involved in regulating actin dynamics in the growth cone. It binds to actin in a one-to-one molar ratio, and stimulates both the severing of actin filaments and depolymerization of actin subunits from the actin filament end. Activated LIMK phosphorylates CFL1 on the conserved serine 3 residue located near the actin-binding site. After phosphorylation, CFL1 is inactive, loses its affinity for actin and dissociates from G-actin monomers. Once freed, ADP-actin monomers can exchange ADP with cytoplasmic ATP, ready for reincorporation at the barbed end of a growing filament (Gungabissoon & Bamburg 2003).
R-HSA-419644 (Reactome) Binding of Hsp90 to the LIMK proteins protects them from degradation and promotes their dimer formation and transphosphorylation. It is estimated that LIMK1 contains at least 5 phospho-amino acids primarily phospho-serines, in its kinase domain. The positions of these serine residues are not known. Transphosphorylation of these serine residues in LIMK1 increases its stability.
R-HSA-419645 (Reactome) After phosphorylation on Thr 508, LIMK undergoes homodimerization. Homodimer formation is promoted by the binding of heat shock protein 90 (Hsp90) to a short sequence in the kinase domain of LIMKs. LIMKs are further phosphorylated after homodimer formation and transphosphorylation of the kinase domain.
R-HSA-442586 (Reactome) Wiskott-Aldrich syndrome protein (WASP) and Neural-WASP (N-WASP, WASL) proteins are scaffolds that transduce signals from cell surface receptors to the activation of the ARP2/3 complex and actin polymerization. WASP and N-WASP possess a central GTPase binding domain (GBD) and an NH2-terminal WASP homology domain 1 (WH1) followed by a basic region (B), and a C-terminal VCA region that contains: a V domain (verprolin homology/WASP homology 2), a C domain (connecting), and an A motif (acidic). The VCA region is responsible for binding to and activating the ARP2/3 complex (Bompard & Caron 2004, Callebaut et al 1998). Under resting conditions, WASP and N-WASP are maintained in an autoinhibited state via interaction of the GBD and the VCA domains. This prevents access of the ARP2/3 complex and G-actin to the VCA region. Activated CDC42 binds to the GBD region of WASPs and this interaction releases the VCA region from autoinhibition, enabling binding of the ARP2/3 complex and stimulating actin polymerization (Kim et al 2000, Park & Cox 2009). Phosphoinositides (PtdIns(4,5)P2) interact with the basic (B) region in WASPs and this interaction is important for activation of the WASPs and the ARP2/3 complex (Higgs & Pollard 2000).
R-HSA-442592 (Reactome) Once WASPs (WASP and N-WASP) and WAVEs (WAVE2 and probably WAVE1 and WAVE3) are activated, their VCA region becomes available for binding to the ARP2/3 complex and actin monomer (G-actin). The actin monomer binds to the V domain and ARP2/3 complex binds to the CA domain. The simultaneous binding of G-actin and the ARP2/3 complex to the VCA region contributes to the activation of the ARP2/3-complex-mediated actin polymerization. The VCA module acts as a platform on which an actin monomer binds to the ARP2/3 complex to trigger actin polymerization (Takenawa & Suetsugu 2007).
RAC1/CDC42:PAK dimerArrowR-HSA-2029456 (Reactome)
RAC1/CDC42:PAK dimerR-HSA-2029454 (Reactome)
RAC1/CDC42:p-S144,T423-PAKArrowR-HSA-2029454 (Reactome)
RAC1:GDPR-HSA-2029451 (Reactome)
RAC1:GDPR-HSA-2029467 (Reactome)
RAC1:GTPArrowR-HSA-2029451 (Reactome)
RAC1:GTPArrowR-HSA-2029467 (Reactome)
RAC1:GTPR-HSA-2029465 (Reactome)
SH3 domain proteinsR-HSA-2197691 (Reactome)
SYKR-HSA-2029452 (Reactome)
Src family kinases (SFKs)mim-catalysisR-HSA-2029459 (Reactome)
Src-kinasesmim-catalysisR-HSA-2197698 (Reactome)
VAV1,2,3R-HSA-2029458 (Reactome)
WASP/N-WASPR-HSA-442586 (Reactome)
WAVE Regulatory ComplexR-HSA-2029465 (Reactome)
WIP family proteinsR-HSA-2197691 (Reactome)
WRC:IRSp53/58:RAC1:GTP:PIP3ArrowR-HSA-2029465 (Reactome)
WRC:IRSp53/58:RAC1:GTP:PIP3R-HSA-2130194 (Reactome)
clustered IgG-Ag:FCGRsR-HSA-2029459 (Reactome)
clustered IgG-Ag:p-FCGRs:SYKArrowR-HSA-2029452 (Reactome)
clustered IgG-Ag:p-FCGRs:SYKR-HSA-2029449 (Reactome)
clustered IgG-Ag:p-FCGRs:SYKmim-catalysisR-HSA-2029449 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCGArrowR-HSA-2029270 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCGR-HSA-2029268 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCGmim-catalysisR-HSA-2029268 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAVArrowR-HSA-2029458 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAVR-HSA-2029453 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCGArrowR-HSA-2029268 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCGR-HSA-2029272 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-VAVArrowR-HSA-2029453 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-VAVmim-catalysisR-HSA-2029451 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYKArrowR-HSA-2029272 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYKArrowR-HSA-2029449 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYKR-HSA-2029270 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYKR-HSA-2029273 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYKR-HSA-2029458 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYKR-HSA-2197697 (Reactome)
clustered IgG-Ag:p-FCGRs:p-6Y-SYKmim-catalysisR-HSA-2029453 (Reactome)
clustered IgG-Ag:p-FCGRsArrowR-HSA-2029459 (Reactome)
clustered IgG-Ag:p-FCGRsArrowR-HSA-2029476 (Reactome)
clustered IgG-Ag:p-FCGRsR-HSA-2029452 (Reactome)
clustered IgG-Ag:p-FCGRsR-HSA-2029476 (Reactome)
p-4Y-PLCG1mim-catalysisR-HSA-167686 (Reactome)
p-PLCGArrowR-HSA-2029272 (Reactome)
p-S144,T423-PAK1ArrowR-HSA-2029454 (Reactome)
p-S144,T423-PAK1mim-catalysisR-HSA-2029460 (Reactome)
p-T,Y MAPK dimersmim-catalysisR-HSA-2029469 (Reactome)
p-T508-LIMK1ArrowR-HSA-2029460 (Reactome)
p-T508-LIMK1R-HSA-419645 (Reactome)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3ArrowR-HSA-2029469 (Reactome)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3ArrowR-HSA-2130194 (Reactome)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3R-HSA-2029469 (Reactome)
pCofilin: Active LIMK-1ArrowR-HSA-399950 (Reactome)
pLIMK dimer:HSP-90ArrowR-HSA-419645 (Reactome)
pLIMK dimer:HSP-90R-HSA-419644 (Reactome)
pLIMK dimer:HSP-90mim-catalysisR-HSA-419644 (Reactome)
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