PI3K-AKT-mTOR signaling and therapeutic opportunities in prostate cancer (Homo sapiens)
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Description
This pathway is based on figure 1 from Merritt et al. (See Bibliography). The PI3K-AKT-mTOR signaling pathway has been shown to have a significant correlation with the development of castration-resistant prostate cancer. The signaling pathway regulates many cellular processes such as protein synthesis, proliferation, survival, metabolism, and differentiation, all factors that would increase a cancerous cell’s ability to survive. Scientists have explored the use of various inhibitors for different parts of the signaling pathway, and have been faced with varying success.
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Bibliography
- Merritt P Edlind, Andrew C Hsieh; ''PI3K-AKT-mTOR singaling in prostate cancer progression and androgen deprivation therapy resistance''; NIH, 2014 PubMed Europe PMC Scholia
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