DNA replication (Homo sapiens)

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RFC36Cdt1Pre-replicative complexCdt1UbiquitinOrc2Processive complexOrc3Orc3Orc complexMcm6Mcm4Cdc6DNA polymerase alpha:primase: origin complexMcm5Orc3RNA primer-DNA primerOrc3Phosphorylated Cdc6Degraded by proteasome in cytosolRNA primer-DNA primerOrc2Orc4Mcm 4,6,7 trimer forms andassociates with the replication forkMcm6Orc13. DNA replication initiationMcm7Mcm4RFC40RFC37Ubiquitinated Cdc6Degraded byproteasomein cytosolCdc6Mcm7PrimaseCdc6RFC1405. Leading/lagging strand synthesisCdt1Orc5p49RNA primer-DNA primer:origin duplex:PCNAMcm10DNA polymerase alpha:primase: origin complexDNAPolymerase ACdt1Orc5p70Orc complexMcm31. Assembly of the pre-replicative complexCdt1Orc complexMcm5RFC Heteropentamer:RNA primer-DNA primerMcm22. Activation of the pre-replicative complexOrc2UbiquitinUbiquitinated Orc1p180Mcm2RNA PrimerOrc complexPhosphorylated Orc1Mcm10Orc4Mcm3Orc5RFC38Geminin4. Switching of origins to post-replicative stateRFC Heteropentamer:RNA primer-DNA primerPCNA homotrimerPhosphorylation ofMcm 2-7 complexCdc6Orc2p58Pre-replicative complexOrc complexOriginORC1LRFC4MCM2RFC5RPA2UTPPOLD2ATPMCM10RFC3ATPADPPCNAPOLE2GMNNdCTPRPA3POLD1PRIM1POLEdUTPCDK2ORC6LRFC1CTPORC5LMCM5CDC7UBA52RFC2RPA4ATPPOLD3dATPORC4LORC3LMCM6MCM4ORC2LMCM7dGTPMCM3PRIM2AASKPOLD4GTPADPCDC6CDT1UBCCDC45LATPPOLAPOLA2RPA1


Description

No description

Comments

GenMAPP notes 
http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.reactome.org

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Quality Tags

Ontology Terms

 

Bibliography

  1. Bell SP, Dutta A; ''DNA replication in eukaryotic cells.''; Annu Rev Biochem, 2002 PubMed Europe PMC Scholia
  2. Cimbora DM, Groudine M; ''The control of mammalian DNA replication: a brief history of space and timing.''; Cell, 2001 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
128700view16:52, 20 February 2024Khanspersremoved brackets from three groups
117096view11:31, 17 May 2021EweitzModified title
107180view14:26, 17 September 2019MaintBotChEBI identifier normalization
106374view00:56, 23 August 2019KhanspersModified description
105566view06:22, 9 August 2019KhanspersModified description
104049view16:27, 27 April 2019DeSlAdded new anchor for PCNA
104048view16:21, 27 April 2019DeSlOntology Term : 'DNA replication pathway' added !
104047view16:19, 27 April 2019DeSlAdded references.
102301view20:51, 17 December 2018Khanspersremoved GenMAPP comment
96302view18:25, 7 March 2018EgonwReplaced a secondary ChEBI identifier with a primary identifier.
94886view18:02, 11 October 2017AlexanderPicoReattached interactions to anchors
94885view18:01, 11 October 2017AlexanderPicoReattached interactions to anchors
89897view13:12, 6 October 2016MkutmonModified description
89893view13:09, 6 October 2016MkutmonModified description
89891view13:08, 6 October 2016MkutmonReverted to version '14:46, 29 April 2015' by Mkutmon
89889view13:07, 6 October 2016MkutmonModified description
79981view14:46, 29 April 2015Zari
76196view22:59, 16 June 2014MaintBotminor move - test
70091view18:20, 12 July 2013MaintBotupdating to 2013 schema
41036view23:15, 1 March 2011MaintBotRemoved redundant pathway information and comments
34997view23:26, 9 February 2010KhanspersModified description
34437view18:16, 10 December 2009MaintBotAutomatic update of empty xrefs
32440view17:17, 15 August 2009MaintBotFixed text labels
32113view13:49, 14 August 2009MaintBotFixed group labels
21660view11:32, 14 November 2008MaintBot[[Pathway:Homo sapiens:DNA replication Reactome]] moved to [[Pathway:WP466]]: Moved to stable identifier
13884view13:07, 19 May 2008Thomasadded connectors and merged multi-line labels
13882view13:04, 19 May 2008ThomasWIP on connectors
13880view12:50, 19 May 2008ThomasWIP on connecting lines
13055view11:12, 17 May 2008MaintBotautomated metabolite conversion
12949view10:44, 17 May 2008MaintBotSticky edges patch by Sjoerd
12482view10:24, 15 May 2008ThomasModified categories
11947view00:15, 13 May 2008KhanspersUpdated pathway
7990view13:46, 7 January 2008MaintBot[[Pathway:Human:DNA replication Reactome]] moved to [[Pathway:Homo sapiens:DNA replication Reactome]]: Renaming species
7619view16:04, 18 December 2007MaintBotfixed category names
7209view12:33, 4 November 2007MaintBotAdded categories to GPML
19417view22:17, 22 May 2007D.Korengpml file for [[Human:DNA_replication_Reactome]]
6307view22:17, 22 May 2007Kdahlquistgpml file for [[Human:DNA_replication_Reactome]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADPMetabolite58-64-0 (CAS)
ASKGeneProduct10926 (Entrez Gene)
ATPMetabolite1927-31-7 (CAS)
CDC45LGeneProduct8318 (Entrez Gene)
CDC6GeneProduct990 (Entrez Gene)
CDC7GeneProduct8317 (Entrez Gene)
CDK2GeneProduct1017 (Entrez Gene)
CDT1GeneProduct81620 (Entrez Gene)
CTPMetabolite65-47-4 (CAS)
GMNNGeneProduct51053 (Entrez Gene)
GTPMetabolite2564-35-4 (CAS)
MCM10GeneProduct55388 (Entrez Gene)
MCM2GeneProduct4171 (Entrez Gene)
MCM3GeneProduct4172 (Entrez Gene)
MCM4GeneProduct4173 (Entrez Gene)
MCM5GeneProduct4174 (Entrez Gene)
MCM6GeneProduct4175 (Entrez Gene)
MCM7GeneProduct4176 (Entrez Gene)
ORC1LGeneProduct4998 (Entrez Gene)
ORC2LGeneProduct4999 (Entrez Gene)
ORC3LGeneProduct23595 (Entrez Gene)
ORC4LGeneProduct5000 (Entrez Gene)
ORC5LGeneProduct5001 (Entrez Gene)
ORC6LGeneProduct23594 (Entrez Gene)
PCNAGeneProduct5111 (Entrez Gene)
POLA2GeneProduct23649 (Entrez Gene)
POLAGeneProduct5422 (Entrez Gene)
POLD1GeneProduct5424 (Entrez Gene)
POLD2GeneProduct5425 (Entrez Gene)
POLD3GeneProduct10714 (Entrez Gene)
POLD4GeneProduct57804 (Entrez Gene)
POLE2GeneProduct5427 (Entrez Gene)
POLEGeneProduct5426 (Entrez Gene)
PRIM1GeneProduct5557 (Entrez Gene)
PRIM2AGeneProductENSG00000146143 (Ensembl)
RFC1GeneProduct5981 (Entrez Gene)
RFC2GeneProduct5982 (Entrez Gene)
RFC3GeneProduct5983 (Entrez Gene)
RFC4GeneProduct5984 (Entrez Gene)
RFC5GeneProduct5985 (Entrez Gene)
RPA1GeneProduct6117 (Entrez Gene)
RPA2GeneProduct6118 (Entrez Gene)
RPA3GeneProduct6119 (Entrez Gene)
RPA4GeneProduct29935 (Entrez Gene)
UBA52GeneProduct7311 (Entrez Gene)
UBCGeneProduct7316 (Entrez Gene)
UTPMetabolite9850 (ChEBI)
dATPMetabolite1927-31-7 (CAS)
dCTPMetabolite2056-98-6 (CAS)
dGTPMetabolite2564-35-4 (CAS)
dUTPMetabolite17625 (ChEBI)

Annotated Interactions

No annotated interactions
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