VEGFA-VEGFR2 signaling (Homo sapiens)

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95STAT3PROCK2PRKD2373795MAPK3T202Y204MAPK1T185Y1873262, 137MAPK1Y187T18594129, 243911151, 102, 16421417532, 90MAP2K3MAP2K6P2721MAPK9MAPK8Y185T183STAT3PMAPK3T183146MAPK3Y204T20214829, 49, 111, 183MAPK1Y18522PRKCZ80, 211PIK3R2ACACBNCF2MAPK12RAP1B133VEGFR2Y1214Y1059Y1175MeK1041Y1054Y996Y9519992, 243197AP1complexPKC delta/ZetadependentSoluble andcleaved FLT1may sequesterVEGFA fromVEGFR2Epoxyeicosatrienoicacid regioisomersEC proliferation,migration,tube formationand angiogenesisCYCell motilityand tube formationEC Migration andTube Formation133, 154157FADDTCEB3FAF1FASBIN1BMXHDAC1TNFRSF10CHSPA1ASMARCA2226DOK1PGAB1PReceptorPROTEINLigandProtein translocation LEGENDMultiple colored edges are introduced to distinguish the connecting nodesPhosphorylated form with/without site & residueEndosomeNucleusMitochondrionCytoplasmPlasma membraneMTEndoplasmic reticulumCYPMNUERENVEGFR2Y951Y801Y1214Y1054Y1175Y1059127VEGFA252MAPK14P114, 225225F-actinreorganization20, 225225Stress fibreformationFocal adhesionassembly andcell migration225NCK1PFYNPPAK2P133STAT1PSTAT6P48, 134STAT1PSTAT6P134NUFRS2PCRKPPRKCI79797979133SRCY530Y419113130RAPGEF1148148RAP1AGTP148ITGAVITGB3Y773148BCAR1P127, 193PLCG1UbY783231SHC1193SHC219322, 133PTK2Y407S732Y576Y397Y861237IQGAP1PRAC1100, 142GTP197197Directed Cell migration73, 197, 202ITGB5ITGB1ITGAV16145, 161161161235SH2D2A174174207VascularpermeabilityNAADP152TPCN2Ca2+Ca2+Ca2+Ca2+Ca2+Ca2+152152H+H+H+ATPADP152152152Endolysosomalcalcium storeMAPKAPK2T334114, 234114114114PLAUPIP2IP3DAG333333CAPN2105Ca2+Ca2+Ca2+187MYL9T19S20237Endothelial cellcontraction athigh VEGFA levels237156ROCK1P156, 228RHOAGTP107, 118, 156, 228, 229100RHOCGTP146, 239Endothelial cellProliferationand migration146146MAP2K1S218S22292, 14614624, 113CBL242424ITPR133146PRKCBPRKCAS657223RAF1P102, 214, 223SPHK1PHRASGTP783361PRKD1S738S910S742946194, 157HDAC5S498S25994HDAC5S498S259PRKCDPRKCEPLA2G4AP10251, 102PGI2HSPB1S15S8255S78109NRP1247CAV1Y14130130130CDH5215PTPN11215CSK215215215204PTK2BY40224076, 80HSP90AA113913976, 13952MLLT4168168FHL220020059PLCB3S537S1105128128CDC42GTP128WASF1NCF1PPAK1P200195195PTPN968PTPRZ167676767NCLMYH9NCL13113113113150AKT1T308S47350FOXO1S256AKT1T308S47350, 86, 23050FOXO1S25627, 505050, 215, 224RELANFKBIAP3612612618, 57, 112, 126126PLA2G5RPS6KA5P474747145, 203PIK3R1P143145, 230NOS3S114S117923155, 105, 145NO145LIMK1S323CFL1S355202020, 109VAV2Y172118118FLNB9191, 22091PFN1Y1297777G-actin bindingand actinpolymerization77At cellleadingedge11990, 138ATF2T71T69Promotes endothelial-leukocyte interactions909032Endothelialcell survival32, 218GRB2P113113139, 211PXNpY80, 93, 116170GJA1S282S255S279S368S262238ClathrinmediatedGap junctioninternalization111GJA1S368S255S282S279S262Stress fibreformation119PTPRJ192, 224192, 224224SHBP62626262144, 154144, 1541547676ROCK1P76RPS6KB1T4121TXNIPACP1S-glutathionylation1, 40TXN11, 40ONOO-1150, 125Cysteineoxidationof VEGFR2and SRCPTPN6181181GRB10P21013, 195PRKAA1T183ROSMitochondrial20213CytosolicROS132Angiogenesis13284, 13212, 38, 101cGMP38, 82Angiogenesis12, 38, 101CREB1P98CAMKK215, 84ACACAP84, 21315, 84PRKAA2202ARHGEF15167167RHOJGTP54167167137SHC1S36137PDPK1S241243PIP2PIP3R1CTORMLST8MAPKAP1MTORS2481S24486969MTORRAPTORMLST8243243Non-phosphoform of SHC243NRDG1T345mTORC2mTORC1217117, 218GSK3BS9230166, 243243AKT1S1T266129129129RPS6S235S236129, 166203RAPTORMTORMLST8mTORC1166ER stress-independentVEGF-UPR machinerymediated pathwayEIF2AK3ERN1PATF6EIF2AS51166166166GeneexpressionATF4166166DNAJB9HERPUD1166AKT1S473166133119CAPN2187EZR105105105TRPC1ITPR1191KL121121Ca2+Ca2+Ca2+Ca2+Ca2+121191Calciumreleasefrom ERPIK3CA168TXNIPVEGFR21PLCG1Y783RAB5ACDH5S665CTNND1S268S252CTNNB1CTNNA1S453MAP2K1S222S218MAP2K2185185VEGFR2UbY1175Y121410Lysosomemediatedpartialproteosomaldegradation230 kDa160 kDaFBXW1110EEA144SLC8A1Ca2+Ca2+Ca2+Ca2+28Na+Na+28282828Mostlyclathrindependentinternalization4HGSY334VEGFR2Y1214UbY1175STAM7070GIPC1MYO6163PTPN1135, 1632407NRP177ClathrindependentinternalizationNRP1RAB11VEGFR2NRP183VEGFR2recycling83177SRCY527Y416VAV2Y172RAC1GTP100, 142PAK2PARRB2118, 177177100, 118, 177177177177177177CDH5S655CTNND1CTNNB1ARRB2177177177VE CadherinrecyclingEarly endosomes122122122122Regulation ofcell survivalRegulation ofchromatinremodellingRNA elongationby RNA Pol II122122122VCLS34613913976, 13976, 139139103Regulation ofendothelial cellsproutingCLTC10Involvedin the activationof VEGFR2162MAPKAPK5T182162162NRP2MAP3K5S83MAP2K7PMAP2K4T261JUNS63212121AKT1T308S473CAV1Y14130ARF6108ARF6108ANXA1P190190172NFATC2dePNFATC2deP3, 65, 221, 2313NFATC1NFATC125, 30PTGS2231EC Migration19RND119179, 208, 221EGR15, 25, 1155, 25, 115SRF5, 25, 115NUR4A2NUR4A325PPP3CACREB1P9851, 1023, 65, 179, 208, 221...Ca2+Ca2+Ca2+JAG1DKK1CCL2CXCL8AMOTBMP10179TEAD441, 5311, 158, 179416523PKC delta/betadependentTEAD44123104EndosomeRegulation of receptor endocytosis and recyclingCYNUCYNUCYNUCYNUCYNUCYNUCYNUCYNUNUCYNFKB1RELANFKB1ICAM1SELE112Promotes endothelial-leukocyte interactions11218Endothelialcell survival4848FOXO4S197FOXO327FOXO4FOXO32727CYNUCYNU27Decreasedexpressionby nuclearexport ofFOXO1/3/4Endothelialcell survival27VEGFR2EndosomeRAB4A44RAB4A44ENPMHGSEPS15EPN1OCLNS490UbITCHGap junctiondisruptionNa+Na+7575, 216, 2197575Tight junctiondisruption75Occludininternalizationand proteosomaldegradationHDAC7S194S397S479FLNBK1147220220YWHAE194HDAC7S397S479S194HDAC9S245S254HDAC4S 246S467CY63, 194, 220NUMEF2CCCND114663, 194, 22023, 63, 194, 220RCAN2MMP10MMP14Activationof MEF2 by nuclearexport ofHDACsEC proliferation,migration,tube formationand angiogenesis63, 194, 22023MKNK1PMKNK1P214NUCYEIF4EP214ELK1153OCLNS490Ub49, 75PMENITGAVStimulationof tip cellfilopodiaPLAURPLAU120PLAUProActiveMMP2747426, 71, 120ITGAVITGB1PLAURPLAUCell migrationand invasion120PMENClathrinmediatedF3233NUR4A1VCAM1BCL2L1CYP2C8SOD2ADAMTS1ACKR3EGR3233HBEGFRCAN1CDKN1BNUR4A1MEF2C233VCAM1233CCL2BCL2CTNNB1VEGFA SIGNALING PATHWAY IN ENDOTHELIAL CELLSCTNNB1Y142999, 141Adherensjunctiondisassembly9ATF2T71T69BCL2L132ERG95NOTCH4DLL4130ETS1149AA51, 102, 164164PTGS2S-nitrosylPTGS214NOS314T172PRKG18238, 82ProteinComplexSmallmoleculesTranscriptional regulation of gene expression (multiple colours)Unique solid edges between receptor and other proteinsDirect protein-protein interactions associated with VEGFR2 phospho-Y1175Direct protein-protein interactions associated with VEGFR2 phospho-Y801Direct protein-protein interactions associated with VEGFR2 phospho-Y1214Direct protein-protein interactions associated with VEGFR2 phospho-Y951Direct protein interactions of VEGFR2 for which a specific VEGFR2 phosphosite involvement isnot reported AND also represents direct protein-protein interactions between other proteinsDirect phosphorylations by VEGFR2 AND also represents otherdirect kinase-substrate phosphorylation eventsGeneric edges between proteinsSolid edges Dashed edgesDirect protein-protein interactions or enzyme-substrate reactionsLeads to, through unknown or not reported intermediatesDirect dephosphorylation of substrates by phosphatasesDirect ubiquitination of substrates by E3 ubiquitin ligasesDirect protein cleavage of substrates by proteasesDirect inhibition of protein activityDissociation of direct protein-protein interactionsLeads to, through unknown ornot reported/studied intermediatesUbiquitinated form with/without site & residueMethylated form with/without site & residueGlutathionilated form with/without site & residuePTMsProtein transport across multiple cell compartmentsPIP2 PtdIns(4,5)P2PIP3 PtdIns(3,4,5)P3DAG DiacylglycerolIP3 Inositol triphosphateROS Reactive oxygen speciesONOO- PeroxynitriteNAADP Nicotinic acid adenine dinucleotide phosphateATP Adenosine triphosphateGTP Guanosine triphosphateADP Adenosine diphosphateNO Nitric OxidecGMP Cyclic GMPAA Arachidonic AcidPGI2 Prostaglandin I2S-nitrosilated formPROTEINmRNASmallmoleculesmRNAPROTEINModifiedformIncreasedexpressionDecreasedexpressionPI3K-AKT-MTOR ModuleP38 MAPKModuleJNKModulePLC-PKCModuleERKModuleNFKBModuleFAKModuleRACModuleSTATModuleRHOAModuleADAMTS1VEGFA-165a88FGAMMRN2TNXBIGFBP7GPC1CTGF15524113689206818PGFFGBFGGVEGFA-145aVEGFA-145bVEGFA-111VEGFA-148VEGFA-165aVEGFA-165bVEGFA-121aVEGFA-121bVEGFA-183aVEGFA-183bVEGFA-162VEGFA-206VEGFA-189aVEGFA-189bMultiple VEGFA isoforms196196FLT1Y1169Y1333Y794Y1213244, 245249249249249246, 251248RACK1250250Direct protein-protein interactions associated with FLT1 phospho -Y794, -Y1169, -Y1213 & -Y1333VEGFAVEGFA-165a252242


Description

Angiogenesis, the formation of new blood vessels from pre-existing vasculature, is central to a number of physiological conditions, from embryogenesis to wound healing in adults and is a hallmark of pathological conditions such as tumorigenesis [1-3]. Angiogenesis is mediated by the coordinated action of a variety of growth factors, metabolites and cell adhesion molecules in endothelial cells [4-6]. Vascular endothelial growth factor (VEGF) is the principal angiogenic growth factor modulating neovascularization [7].

The biological effect of VEGF is mediated through specific VEGF receptors on endothelial cell surface. VEGFs (VEGF-A, VEGF-B, VEGF-C and VEGF-D) interact with VEGF receptors such as VEGFR1, VEGFR2 and VEGFR3. Among them, VEGFA/VEGFR2 signaling appears to mediate cellular responses involved in angiogenesis prominently. Further, VEGF/VEGFR1 signaling, though weak, converges to VEGFR2 signaling pathway. VEGFA binding to VEGFR2 at the surface of endothelial cells leads to dimerization and auto-phosphorylation of specific tyrosine residues in the cytoplasmic domain of VEGFR2. It leads to activation of multiple downstream signaling cascades and promotes endothelial cell proliferation, migration, and tube formation relevant to angiogenesis [8]. VEGFR2 dependent activation of PI3K-AKT-mTOR signaling regulates cell survival, cell proliferation, anti-apoptotic and cell permeability functions [9]. Another important pathway of VEGF mediated cell proliferation appears to be through PLCγ-mediated activation of PKC and downstream induction of the ERK and other PKC-dependent pathways [10]. Endothelial cell migration is induced by VEGFA/VEGFR2 signaling through activation of p38MAPK (actin polymerization) and FAK (focal adhesion turnover) which is particularly important in directed migration [11, 12]. Phosphosite specificity towards downstream signalling has also been documented. Phosphosite mapping documented seven phosphosites in VEGFR2 receptor: Y1054, Y1214, Y801, Y1175, Y951, Y1059 and Y996. Phosphorylation of Y1214 and Y1054 regulates signaling events involved in cell migration. Y801 phosphorylation regulates cell survival. Y1175 regulates both cell proliferation and migration. Y951 and Y1059 phosphorylation regulates cell survival, cell migration and cell proliferation.

VEGFA/VEGFR2 signaling network compiles data available in the literature with respect to VEGFA signaling (especially VEGFA-165) through VEGFR2 in endothelial cells. The signaling events involving these proteins were derived from experimentally validated data involving multiple experimental techniques and approaches. Individual signaling events in VEGFR2 signaling networks leading to cell proliferation, migration and survival were identified and categorized into protein-protein interactions, enzyme-catalyzed events, activation/inhibition reactions, transport of protein across subcellular compartments, and gene regulation events. Signaling molecules involved in VEGFA/VEGFR2 signaling were categorized to enzymes, receptors and transcription factors and the contextual activation/deactivation of these molecules downstream to VEGFA/ VEGFR2 signaling, in modulating angiogenesis, is documented.

VEGFA dependent angiogenesis pathway map depicts the integration of signaling pathways regulating cell survival, cell migration, cell proliferation, cellular interactions downstream of VEGFA/VEGFR2 signaling relevant to angiogenesis, regulation of VEGFR2, phosphosite specificity of VEGFR2 towards downstream signaling, post-translational modifications, molecular function-based information, cross-talks among proteins in the canonical signaling modules and the information on the compartmentalization of proteins. The map of VEGFA/VEGFR2 signaling network is interactive to help investigators to add new information as it becomes available in the future for analysis or representation. VEGFA dependent angiogenesis pathway map can be cited as ‘Abhinand CS , Raju R, Soumya SJ, Arya PS, Sudhakaran PR (2016). VEGF-A/VEGFR2 signaling network in endothelial cells relevant to angiogenesis. J Cell Commun Signal. doi: 10.1007/s12079-016-0352-8’.

References

1. Folkman J (1971). Tumor angiogenesis: therapeutic implications. N Engl J Med. 285:1182-1186.

2. Chatterjee S, Heukamp LC, Siobal M et al., 2013. Tumor VEGF: VEGFR2 autocrine feed-forward loop triggers angiogenesis in lung cancer. J Clin Invest. 123:1732-1740.

3. Shibuya M (2014). VEGF-VEGFR Signals in Health and Disease. BiomolTher (Seoul). 22:1-9.

4. Kumar VB, Binu S, Soumya SJ et al., 2014. Regulation of vascular endothelial growth factor by metabolic context of the cell. Glycoconj J. 31:427-434.

5. Kitazume S, Imamaki R, Ogawa K et al., 2014. Sweet role of platelet endothelial cell adhesion molecule in understanding angiogenesis. Glycobiology. 24:1260-1264.

6. Kunhiraman H, Edatt L, Thekkeveedu S et al., 2016. 2‐Deoxy Glucose Modulates Expression and Biological Activity of VEGF in a SIRT‐1 Dependent Mechanism. J Cell Biochem.

7. Lohela M, Bry M, Tammela T et al., 2009. VEGFs and receptors involved in angiogenesis versus lymphangiogenesis. Curr Opin Cell Biol. 21:154-165.

8. Koch S, Claesson-Welsh L, 2012. Signal transduction by vascular endothelial growth factor receptors. Cold Spring Harbor perspectives in medicine. 2(7):a006502.

9. Koch S, Tugues S, Li X et al., 2011. Signal transduction by vascular endothelial growth factor receptors. Biochem J.437:169-183.


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108249view06:59, 3 December 2019Prslab2019 Update version of VEGFA-VEGFR2
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89246view16:01, 25 August 2016KhanspersReverted to version '06:50, 25 August 2016' by Khanspers
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89242view06:50, 25 August 2016PrslabOntology Term : 'vascular endothelial growth factor signaling pathway' added !
89241view06:38, 25 August 2016PrslabModified title
89240view06:34, 25 August 2016PrslabNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ACACAProtein31 (Entrez Gene)
ACACBProtein32 (Entrez Gene)
ACKR3Protein57007 (Entrez Gene)
ACP1Protein52 (Entrez Gene)
ADAMTS1Protein9510 (Entrez Gene)
AKT1Protein207 (Entrez Gene)
AKT1S1Protein84335 (Entrez Gene)
AMOTProtein154796 (Entrez Gene)
ANXA1Protein301 (Entrez Gene)
ARF6Protein382 (Entrez Gene)
ARHGEF15Protein22899 (Entrez Gene)
ARRB2Protein409 (Entrez Gene)
ATF2Protein1386 (Entrez Gene)
ATF4Protein468 (Entrez Gene)
ATF6Protein22926 (Entrez Gene)
BCAR1Protein9564 (Entrez Gene)
BCL2Protein596 (Entrez Gene)
BCL2L1Protein598 (Entrez Gene)
BIN1Protein274 (Entrez Gene)
BMP10Protein27302 (Entrez Gene)
BMXProtein660
CAMKK2Protein10645 (Entrez Gene)
CAPN2Protein824 (Entrez Gene)
CAV1 Protein857 (Entrez Gene)
CBLProtein867 (Entrez Gene)
CCL2Protein6347 (Entrez Gene)
CCND1Protein595 (Entrez Gene)
CDC42Protein998 (Entrez Gene)
CDH5Protein1003 (Entrez Gene)
CDKN1BProtein8013 (Entrez Gene)
CFL1Protein1072 (Entrez Gene)
CLTCProtein1213 (Entrez Gene)
CREB1Protein1385 (Entrez Gene)
CRKProtein1398 (Entrez Gene)
CSKProtein1445 (Entrez Gene)
CTGFProtein1490 (Entrez Gene)
CTNNA1Protein1495 (Entrez Gene)
CTNNB1Protein1499 (Entrez Gene)
CTNND1Protein1500 (Entrez Gene)
CXCL8Protein3576 (Entrez Gene)
CYP2C8 Protein1558 (Entrez Gene)
DKK1Protein22943 (Entrez Gene)
DLL4Protein54567 (Entrez Gene)
DNAJB9Protein4189 (Entrez Gene)
DOK1 Protein1796 (Entrez Gene)
EEA1Protein8411 (Entrez Gene)
EGR1Protein1958 (Entrez Gene)
EGR3Protein1960 (Entrez Gene)
EIF2AProtein83939 (Entrez Gene)
EIF2AK3Protein9451 (Entrez Gene)
EIF4EProtein1977 (Entrez Gene)
ELK1Protein2002 (Entrez Gene)
EPN1Protein29924 (Entrez Gene)
EPS15Protein2060 (Entrez Gene)
ERGProtein2078 (Entrez Gene)
ERN1Protein2081 (Entrez Gene)
ETS1Protein2113 (Entrez Gene)
EZRProtein7430 (Entrez Gene)
F3Protein2152 (Entrez Gene)
FADDProtein8772 (Entrez Gene)
FAF1Protein11124 (Entrez Gene)
FASProtein355 (Entrez Gene)
FBXW11Protein23291 (Entrez Gene)
FGAProtein2243 (Entrez Gene)
FGBProtein2244 (Entrez Gene)
FGGProtein2266 (Entrez Gene)
FHL2Protein2274 (Entrez Gene)
FLNBProtein2317 (Entrez Gene)
FLT1Protein2321 (Entrez Gene)
FOXO1Protein2308 (Entrez Gene)
FOXO3Protein2309 (Entrez Gene)
FOXO4Protein4303 (Entrez Gene)
FRS2Protein10818 (Entrez Gene)
FYN Protein2534 (Entrez Gene)
GAB1Protein2549 (Entrez Gene)
GIPC1Protein10755 (Entrez Gene)
GJA1Protein2697 (Entrez Gene)
GPC1Protein2817 (Entrez Gene)
GRB10Protein2887 (Entrez Gene)
GRB2Protein2885 (Entrez Gene)
GSK3BProtein2932 (Entrez Gene)
HBEGFProtein1839 (Entrez Gene)
HDAC1Protein3065 (Entrez Gene)
HDAC4Protein9759 (Entrez Gene)
HDAC5Protein10014 (Entrez Gene)
HDAC7Protein51564 (Entrez Gene)
HDAC9Protein9734 (Entrez Gene)
HERPUD1Protein9709 (Entrez Gene)
HGSProtein9146 (Entrez Gene)
HRASProtein3265 (Entrez Gene)
HSP90AA1Protein3320 (Entrez Gene)
HSPA1AProtein3303 (Entrez Gene)
HSPB1Protein3315 (Entrez Gene)
ICAM1Protein3383 (Entrez Gene)
IGFBP7Protein3490 (Entrez Gene)
IQGAP1Protein8826 (Entrez Gene)
ITCHProtein83737 (Entrez Gene)
ITGAVProtein3685 (Entrez Gene)
ITGB1Protein3688 (Entrez Gene)
ITGB3Protein3690 (Entrez Gene)
ITGB5Protein3693 (Entrez Gene)
ITPR1Protein3748 (Entrez Gene)
JAG1Protein182 (Entrez Gene)
JUNProtein3725 (Entrez Gene)
KLProtein9365 (Entrez Gene)
LIMK1Protein3984 (Entrez Gene)
MAP2K1Protein5604 (Entrez Gene)
MAP2K2Protein5605 (Entrez Gene)
MAP2K3Protein5606 (Entrez Gene)
MAP2K4Protein6416 (Entrez Gene)
MAP2K6Protein5608 (Entrez Gene)
MAP2K7Protein5609 (Entrez Gene)
MAP3K5Protein4217 (Entrez Gene)
MAPK12Protein6300 (Entrez Gene)
MAPK14Protein1432 (Entrez Gene)
MAPK1Protein5594 (Entrez Gene)
MAPK3Protein5595 (Entrez Gene)
MAPK8Protein5599 (Entrez Gene)
MAPK9Protein5601 (Entrez Gene)
MAPKAP1Protein79109 (Entrez Gene)
MAPKAPK2Protein9261 (Entrez Gene)
MAPKAPK5Protein8550 (Entrez Gene)
MEF2CProtein4208 (Entrez Gene)
MKNK1Protein8569 (Entrez Gene)
MLLT4Protein4301 (Entrez Gene)
MLST8Protein64223 (Entrez Gene)
MMP10Protein4319 (Entrez Gene)
MMP14Protein4323 (Entrez Gene)
MMP2Protein4313 (Entrez Gene)
MMRN2Protein79812 (Entrez Gene)
MTORProtein2475 (Entrez Gene)
MYH9Protein4627 (Entrez Gene)
MYL9Protein4633 (Entrez Gene)
MYO6Protein4646 (Entrez Gene)
NCF1Protein653361 (Entrez Gene)
NCF2Protein4688 (Entrez Gene)
NCK1Protein4690 (Entrez Gene)
NCLProtein4691 (Entrez Gene)
NFATC1Protein4772 (Entrez Gene)
NFATC2Protein4773 (Entrez Gene)
NFKB1Protein4790 (Entrez Gene)
NFKBIAProtein4792 (Entrez Gene)
NOS3Protein4846 (Entrez Gene)
NOTCH4Protein4855 (Entrez Gene)
NRDG1Protein10397 (Entrez Gene)
NRP1Protein8821 (Entrez Gene)
NRP2Protein8828 (Entrez Gene)
NUR4A1Protein3164 (Entrez Gene)
NUR4A2Protein4929 (Entrez Gene)
NUR4A3Protein8013 (Entrez Gene)
OCLNProtein100506658 (Entrez Gene)
PAK1Protein5058 (Entrez Gene)
PAK2Protein5062 (Entrez Gene)
PDPK1Protein5170 (Entrez Gene)
PFN1Protein5216 (Entrez Gene)
PGFProtein5228 (Entrez Gene)
PIK3CAProtein5290 (Entrez Gene)
PIK3R1Protein5295 (Entrez Gene)
PIK3R2Protein5296 (Entrez Gene)
PLA2G4AProtein5321 (Entrez Gene)
PLA2G5Protein5322 (Entrez Gene)
PLAUProtein5328 (Entrez Gene)
PLAURProtein5329 (Entrez Gene)
PLCB3Protein5331 (Entrez Gene)
PLCG1Protein5335 (Entrez Gene)
PPP3CAProtein5530 (Entrez Gene)
PRKAA1Protein5562 (Entrez Gene)
PRKAA2Protein5563 (Entrez Gene)
PRKCAProtein5578 (Entrez Gene)
PRKCBProtein5579 (Entrez Gene)
PRKCDProtein5580 (Entrez Gene)
PRKCEProtein5581 (Entrez Gene)
PRKCIProtein5584 (Entrez Gene)
PRKCZProtein5590 (Entrez Gene)
PRKD1Protein5587 (Entrez Gene)
PRKD2Protein25865 (Entrez Gene)
PRKG1Protein5592 (Entrez Gene)
PTGS2Protein5743 (Entrez Gene)
PTK2Protein5747 (Entrez Gene)
PTK2BProtein2185 (Entrez Gene)
PTPN11Protein5781 (Entrez Gene)
PTPN1Protein5770 (Entrez Gene)
PTPN6Protein5777 (Entrez Gene)
PTPN9Protein5780 (Entrez Gene)
PTPRJProtein5795 (Entrez Gene)
PTPRZ1Protein5803 (Entrez Gene)
PXNProtein5829 (Entrez Gene)
R1CTOR Protein253260 (Entrez Gene)
RAB11Protein8766 (Entrez Gene)
RAB4AProtein5867 (Entrez Gene)
RAB5AProtein5868 (Entrez Gene)
RAC1Protein5879 (Entrez Gene)
RACK1Protein10399 (Entrez Gene)
RAF1Protein5894 (Entrez Gene)
RAP1AProtein5906 (Entrez Gene)
RAP1BProtein5908 (Entrez Gene)
RAPGEF1Protein2889 (Entrez Gene)
RAPTORProtein253260 (Entrez Gene)
RCAN1Protein1827 (Entrez Gene)
RCAN2Protein10231 (Entrez Gene)
RELAProtein5970 (Entrez Gene)
RHOAProtein387 (Entrez Gene)
RHOCProtein389 (Entrez Gene)
RHOJProtein57381 (Entrez Gene)
RND1Protein27289 (Entrez Gene)
ROCK1Protein6093 (Entrez Gene)
ROCK2Protein9475 (Entrez Gene)
RPS6Protein6194 (Entrez Gene)
RPS6KA5Protein9252 (Entrez Gene)
RPS6KB1Protein6198 (Entrez Gene)
SELEProtein6401 (Entrez Gene)
SH2D2AProtein9047 (Entrez Gene)
SHBProtein6461 (Entrez Gene)
SHC1Protein6464 (Entrez Gene)
SHC2Protein25759 (Entrez Gene)
SLC8A1Protein6546 (Entrez Gene)
SMARCA2Protein6595 (Entrez Gene)
SOD2Protein6648 (Entrez Gene)
SPHK1Protein55872 (Entrez Gene)
SRCProtein6714 (Entrez Gene)
SRFProtein6722 (Entrez Gene)
STAMProtein8027 (Entrez Gene)
STAT1Protein6772 (Entrez Gene)
STAT3Protein6774 (Entrez Gene)
STAT6Protein6778 (Entrez Gene)
TCEB3Protein6924 (Entrez Gene)
TEAD4Protein7004 (Entrez Gene)
TNFRSF10CProtein8794 (Entrez Gene)
TNXBProtein7148 (Entrez Gene)
TPCN2Protein219931 (Entrez Gene)
TRPC1Protein7220 (Entrez Gene)
TXNProtein7295 (Entrez Gene)
TXNIPProtein10628 (Entrez Gene)
VAV2Protein7410 (Entrez Gene)
VCAM1Protein5328 (Entrez Gene)
VCLProtein7414 (Entrez Gene)
VEGFAProtein7422 (Entrez Gene)
VEGFR2Protein3791 (Entrez Gene)
WASF1Protein8936 (Entrez Gene)
YWHAEProtein7531 (Entrez Gene)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP3888"
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