ATR signaling (Homo sapiens)
From WikiPathways
Description
This pathway is modeled after Figure 1 in the article " ATR signalling: more than meeting at the fork" (See Bibliography). This pathway details the ATR signaling which commences when there is a gap in the single strand DNA. It details the usage of several independent checkpoint proteins which then cause TOPBP1 dependent activation of the phosphorylation and kinase of a large number of substrates including CHK1 to commence regulation of cellular response to DNA damage and replication stress.
Quality Tags
Ontology Terms
Saving...Bibliography
- Nam EA, Cortez D; ''ATR signalling: more than meeting at the fork.''; Biochem J, 2011 PubMed Europe PMC Scholia
History
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External references
DataNodes
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| Name | Type | Database reference | Comment |
|---|---|---|---|
| ATR | GeneProduct | ENSG00000175054 (Ensembl)  | |
| ATRIP | GeneProduct | ENSG00000282827 (Ensembl) | |
| CHK1 | GeneProduct | ENSG00000149554 (Ensembl) | |
| HUS1 | GeneProduct | ENSG00000136273 (Ensembl) | |
| RAD1 | GeneProduct | ENSG00000113456 (Ensembl) | |
| RAD9A | GeneProduct | ENSG00000172613 (Ensembl) | |
| RAD9B | GeneProduct | ENSG00000151164 (Ensembl) | |
| RPA | GeneProduct | ENSG00000132383 (Ensembl) | |
| TOPBP1 | GeneProduct | ENSG00000163781 (Ensembl) |
Annotated Interactions
No annotated interactions
