H19, Rb-E2F1, and CDK-beta-catenin in colorectal cancer (Homo sapiens)

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1CRC growthPhosphorylationH19macroH2ACTNNB1G1-S transitionCDK4CCND1E2F1CDK8CDK8MED1CSRP2JAG1SOX4CDH1TULP3PMAIP1RB1PCRC migrationE2F1RB1


Description

A scheme of H19 action: we provided additional insights of H19 on Rb-E2F1 signaling and CDK-β-catenin activity. We propose that H19 interacts with macroH2A, and this may consequently lead to de-repression of genes including CDK8, CDK4, and CCND1. Increased CDK4-cyclin D1 complex phosphorylates Rb to disrupt Rb-E2F1 interaction, leading to E2F1 activation. The increase of CDK8 expression enhances the function of mediator complex including MED1, and facilitates the gene regulation by β-catenin. These downstream targets could work in a synergistic way of promoting cell proliferation and increasing cell motility in CRC.

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Bibliography

  1. Ohtsuka M, Ling H, Ivan C, Pichler M, Matsushita D, Goblirsch M, Stiegelbauer V, Shigeyasu K, Zhang X, Chen M, Vidhu F, Bartholomeusz GA, Toiyama Y, Kusunoki M, Doki Y, Mori M, Song S, Gunther JR, Krishnan S, Slaby O, Goel A, Ajani JA, Radovich M, Calin GA; ''H19 Noncoding RNA, an Independent Prognostic Factor, Regulates Essential Rb-E2F and CDK8-β-Catenin Signaling in Colorectal Cancer.''; EBioMedicine, 2016 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129540view15:49, 10 May 2024EweitzModified description
129539view15:49, 10 May 2024EweitzModified title
129345view09:22, 27 March 2024MkutmonOntology Term : 'signaling pathway' added !
123402view06:27, 23 July 2022EgonwMade a pathway clickable
106437view23:25, 28 August 2019KhanspersModified description
105518view06:53, 8 August 2019KhanspersModified description
97690view00:59, 2 June 2018AlexanderPicoModified title
94706view04:13, 5 October 2017KhanspersModified description
94300view05:06, 1 September 2017Khanspersupdated layout
91527view23:01, 8 March 2017Khanspersclarified phosphorylation event
91497view23:15, 6 March 2017KhanspersOntology Term : 'colorectal cancer' added !
91496view23:14, 6 March 2017KhanspersModified description
91495view23:13, 6 March 2017KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CCND1GeneProductENSG00000110092 (Ensembl)
CDH1GeneProductENSG00000039068 (Ensembl)
CDK4GeneProductENSG00000135446 (Ensembl)
CDK8GeneProductENSG00000132964 (Ensembl)
CSRP2GeneProductENSG00000175183 (Ensembl)
CTNNB1GeneProductENSG00000168036 (Ensembl)
E2F1GeneProductENSG00000101412 (Ensembl)
G1-S transitionPathwayWP45 (WikiPathways)
H19RnaENSG00000130600 (Ensembl)
JAG1GeneProductENSG00000101384 (Ensembl)
MED1GeneProductENSG00000125686 (Ensembl)
PMAIP1GeneProductENSG00000141682 (Ensembl)
RB1GeneProductENSG00000139687 (Ensembl)
SOX4GeneProductENSG00000124766 (Ensembl)
TULP3GeneProductENSG00000078246 (Ensembl)
macroH2AGeneProductENSG00000113648 (Ensembl)

Annotated Interactions

No annotated interactions

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