mir-193a and MVP in colon cancer metastasis (Mus musculus)
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Description
Proposed model for the mechanism of colon cancer metastasis to the liver involves exporting miR-193a via exosomes sorted by major vault protein (MVP).
In pre-metastatic cells miR-193a suppresses mouse colon cancer progression by directly targeting Caprin1, which is known to positively regulate the cell cycle and cell proliferation. Higher levels of miR-193a in tumor cells causes of cell cycle G1 arrest and cell proliferation repression through reduction of Caprin1 expression. In metatstatic cells, increased levels of MVP leads to MVP-mediated selective sorting of tumor suppressor miRNA into exosomes, which promotes tumor progression.
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Ontology Terms
Saving...Bibliography
- Teng Y, Ren Y, Hu X, Mu J, Samykutty A, Zhuang X, Deng Z, Kumar A, Zhang L, Merchant ML, Yan J, Miller DM, Zhang HG; ''MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression.''; Nat Commun, 2017 PubMed Europe PMC Scholia
History
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External references
DataNodes
| View all... |
| Name | Type | Database reference | Comment |
|---|---|---|---|
| Caprin1 | GeneProduct | ENSMUSG00000027184 (Ensembl)  | |
| Ccnd1 | GeneProduct | ENSMUSG00000070348 (Ensembl) | |
| Ccnd2 | GeneProduct | ENSMUSG00000000184 (Ensembl) | |
| G3bp1 | GeneProduct | ENSMUSG00000018583 (Ensembl) | |
| Mvp | GeneProduct | ENSMUSG00000030681 (Ensembl) | |
| Myc | GeneProduct | ENSMUSG00000022346 (Ensembl) | |
| mir193a | Rna | ENSMUSG00000065395 (Ensembl) |
Annotated Interactions
No annotated interactions
