Prader-Willi and Angelman syndrome (Homo sapiens)

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AS ICFollicle stimulating hormoneLuteinizing hormonePWS regionRB signallingGABA(A) receptorTranscription of INK4/ARF locusBreakpoint 3telomereAS regionBreakpoint 2Literature1-13, 17-19centromereBreakpoint 1Non-imprintedRB1GABA(A) receptor subunit alpha-5GABA(A) receptorsubunit deltaTyrosinasep53P-proteinLHBCDK4Melanin biosynthesisCCND1ApoptosisSignaling pathway in GlioblastomaG2/M arrestGABA(A) receptorsubunit rhoGABA(A) receptor subunit beta-3CDKN2BFSHBNK3Rp16-INK4aMDM2KISS1SLC45A2NKBL-dopaquinoneHERC2GABA(A) receptorsubunit gammaCDC6G1/S progressionE2F1CCND2CGAL-tyrosineMDM4ARF2, 8IPWSNORD116@1OCA2MAGEL211-13CYFIP1GABRA5GABRB37Peptide hormone biosynthesisGHRH (1-108)GHRH (32-75)PCSK1TUBGCP5NHLH2Insulin (25-110)1, 4POMC (1-241)Oxytocin-neurophysin 1 (1-125)Ca2+GABRG3Ghrelin (24-51)SNORD115@17NIPA2GNRH1 (24-92)POMC (138-176)NIPA1Spliceosomal A complexATP10ASNORD107mRNA processingMajor splicing pathwayInsulin B chain(25-54)Synthesis, secretion and deacylation of ghrelinInsulin processingSNURFPWRN1GNRH1 (24-33)SNRPNNDN9, 10, 13UBE3A5BDNF (1-247)MKRN38NPAP1SNORD64SNORD109ASNORD109BNon-imprintedPWS ICOxytocin (20-28)BDNF (129-247)Ghrelin (1-117)SNURF-SNRPN6Spliceosomal E complexPCSK1Insulin A chain(90-110)Insulin (57-87)MKRN38GNRH1 (24-33)CGAUBE3AE2F15UBE3Ap16-INK4aCDKN2CCCND1CCND2CDK6E2F1Signaling pathway in GlioblastomaGABRB37GABRA5OCA27GABRG31112109, 1313Molecular motor kinesinDynein microtubule based molecular motorDevelopment of hypothalamic anorexigenic circuits(interaction by Fez orthologue UNC-76)Leptin mediated depolarisation of POMC neuronsDNA transcriptionNdn mice embryos (C57BL/6J line)tm2StwAxonal transportD. melanogasterFormation of centrosomalmicrotubule organising centerMSX1DLX5MAGEL2FEZ2Proteasome degradationpathwayNDNPCM1FEZ1BBS4Neurite/axonal outgrowth13PC12 cellsNeurite outgrowthNGFFEZ1PRKCZBBS4GNRH1GT1-7 cells16, 17Alternate splicingFull-length 5-HT2C receptors14, 16-18POMC neuronsAdenosine-to-inosineRNA-editing15-17, 195'-...CGGUAUGUAGCAAUACGUAAUCCUAUUGAGCAUAGCC...-3'SNORD115HTR2C pre-mRNA3'-...GAGUCGCAUUAGGAUAACUCGUACUAA...-5'HTR2C mRNAExon IHTR2CSNORD115@16, 17IIIIIIVVaVbVI


Description

Prader Willi and Angelman syndrome

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Bekker-Jensen S, Rendtlew Danielsen J, Fugger K, Gromova I, Nerstedt A, Lukas C, Bartek J, Lukas J, Mailand N; ''HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes.''; Nat Cell Biol, 2010 PubMed Europe PMC Scholia
  2. Homanics GE, DeLorey TM, Firestone LL, Quinlan JJ, Handforth A, Harrison NL, Krasowski MD, Rick CE, Korpi ER, Mäkelä R, Brilliant MH, Hagiwara N, Ferguson C, Snyder K, Olsen RW; ''Mice devoid of gamma-aminobutyrate type A receptor beta3 subunit have epilepsy, cleft palate, and hypersensitive behavior.''; Proc Natl Acad Sci U S A, 1997 PubMed Europe PMC Scholia
  3. Miller NL, Wevrick R, Mellon PL; ''Necdin, a Prader-Willi syndrome candidate gene, regulates gonadotropin-releasing hormone neurons during development.''; Hum Mol Genet, 2009 PubMed Europe PMC Scholia
  4. Lee S, Walker CL, Karten B, Kuny SL, Tennese AA, O'Neill MA, Wevrick R; ''Essential role for the Prader-Willi syndrome protein necdin in axonal outgrowth.''; Hum Mol Genet, 2005 PubMed Europe PMC Scholia
  5. Neumann LC, Markaki Y, Mladenov E, Hoffmann D, Buiting K, Horsthemke B; ''The imprinted NPAP1/C15orf2 gene in the Prader-Willi syndrome region encodes a nuclear pore complex associated protein.''; Hum Mol Genet, 2012 PubMed Europe PMC Scholia
  6. Chumová J, Trögelová L, Kourová H, Volc J, Sulimenko V, Halada P, Ku�era O, Benada O, Kuchařová A, Klebanovych A, Dráber P, Daniel G, Binarová P; ''γ-Tubulin has a conserved intrinsic property of self-polymerization into double stranded filaments and fibrillar networks.''; Biochim Biophys Acta Mol Cell Res, 2018 PubMed Europe PMC Scholia
  7. Burns CM, Chu H, Rueter SM, Hutchinson LK, Canton H, Sanders-Bush E, Emeson RB; ''Regulation of serotonin-2C receptor G-protein coupling by RNA editing.''; Nature, 1997 PubMed Europe PMC Scholia
  8. Garfield AS, Davies JR, Burke LK, Furby HV, Wilkinson LS, Heisler LK, Isles AR; ''Increased alternate splicing of Htr2c in a mouse model for Prader-Willi syndrome leads disruption of 5HT2Creceptor mediated appetite.''; Mol Brain, 2016 PubMed Europe PMC Scholia
  9. Colmers WF, Wevrick R; ''Leptin signaling defects in a mouse model of Prader-Willi syndrome: An orphan genetic obesity syndrome no more?''; Rare Dis, 2013 PubMed Europe PMC Scholia
  10. Navarro VM, Gottsch ML, Wu M, García-Galiano D, Hobbs SJ, Bosch MA, Pinilla L, Clifton DK, Dearth A, Ronnekleiv OK, Braun RE, Palmiter RD, Tena-Sempere M, Alreja M, Steiner RA; ''Regulation of NKB pathways and their roles in the control of Kiss1 neurons in the arcuate nucleus of the male mouse.''; Endocrinology, 2011 PubMed Europe PMC Scholia
  11. ''mRNA splicing - major pathway''; Reactome; R-HSA-72163.2, DOI Scholia
  12. Mercer RE, Michaelson SD, Chee MJ, Atallah TA, Wevrick R, Colmers WF; ''Magel2 is required for leptin-mediated depolarization of POMC neurons in the hypothalamic arcuate nucleus in mice.''; PLoS Genet, 2013 PubMed Europe PMC Scholia
  13. Abreu AP, Macedo DB, Brito VN, Kaiser UB, Latronico AC; ''A new pathway in the control of the initiation of puberty: the MKRN3 gene.''; J Mol Endocrinol, 2015 PubMed Europe PMC Scholia
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  15. Delahanty RJ, Zhang Y, Bichell TJ, Shen W, Verdier K, Macdonald RL, Xu L, Boyd K, Williams J, Kang JQ; ''Beyond Epilepsy and Autism: Disruption of GABRB3 Causes Ocular Hypopigmentation.''; Cell Rep, 2016 PubMed Europe PMC Scholia
  16. Donnelly MP, Paschou P, Grigorenko E, Gurwitz D, Barta C, Lu RB, Zhukova OV, Kim JJ, Siniscalco M, New M, Li H, Kajuna SL, Manolopoulos VG, Speed WC, Pakstis AJ, Kidd JR, Kidd KK; ''A global view of the OCA2-HERC2 region and pigmentation.''; Hum Genet, 2012 PubMed Europe PMC Scholia
  17. Schenck A, Bardoni B, Moro A, Bagni C, Mandel JL; ''A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P.''; Proc Natl Acad Sci U S A, 2001 PubMed Europe PMC Scholia
  18. Kuroda S, Nakagawa N, Tokunaga C, Tatematsu K, Tanizawa K; ''Mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth is a protein kinase C zeta-interacting protein.''; J Cell Biol, 1999 PubMed Europe PMC Scholia
  19. ''Mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth is a protein kinase C zeta-interacting protein.''; J Cell Biol, 1999
  20. Burnett LC, LeDuc CA, Sulsona CR, Paull D, et al; ''Deficiency in prohormone convertase PC1 impairs prohormone processing in Prader-Willi Syndrome''; J Clin Invest, 2017 PubMed Europe PMC Scholia
  21. Gamell C, Gulati T, Levav-Cohen Y, Young RJ, Do H, Pilling P, Takano E, Watkins N, Fox SB, Russell P, Ginsberg D, Monahan BJ, Wright G, Dobrovic A, Haupt S, Solomon B, Haupt Y; ''Reduced abundance of the E3 ubiquitin ligase E6AP contributes to decreased expression of the INK4/ARF locus in non-small cell lung cancer.''; Sci Signal, 2017 PubMed Europe PMC Scholia
  22. Brange J, Langkjoer L; ''Insulin structure and stability.''; Pharm Biotechnol, 1993 PubMed Europe PMC Scholia
  23. Ehrhart F, Janssen KJM, Coort SL, Evelo CT, Curfs LMG2; ''Prader-Willi Syndrome and Angelman Syndrome: Visualisation of the molecular pathways for two chromosomal disorders''; World J Biol Psychiatry, 2018 PubMed Europe PMC Scholia
  24. Lee S, Walker CL, Karten B, Kuny SL, Tennese AA, O'Neill MA, Wevrick R; ''Essential role for the Prader-Willi syndrome protein necdin in axonal outgrowth''; Hum Mol Genet, 2005 PubMed Europe PMC Scholia
  25. Maillard J, Park S, Croizier S, Vanacker C, Cook JH, Prevot V, Tauber M, Bouret SG; ''Loss of Magel2 impairs the development of hypothalamic Anorexigenic circuits.''; Hum Mol Genet, 2016 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
134606view06:26, 23 July 2024EgonwAdded a missing datasource
134605view06:26, 23 July 2024EgonwRemoved template comments
127157view15:16, 7 August 2023Fehrhartlegend correction
127156view15:12, 7 August 2023FehrhartModified description
127155view15:09, 7 August 2023FehrhartModified description
127154view15:07, 7 August 2023Fehrhartupdate
127153view10:31, 7 August 2023Fehrhartupdate
125298view17:32, 31 January 2023LarsgwAdd DOI to reference
123316view12:01, 15 July 2022Fehrhartupdate in progress
123312view10:51, 15 July 2022Fehrhartupdate
123122view18:06, 4 July 2022EgonwMade multiple pathways clickable
119303view13:04, 23 June 2021FinterlyAdded Reactome info to PublicationXref
117171view09:55, 18 May 2021EweitzModified title
113877view16:32, 3 December 2020Fehrhartupdated IPW ID and color (RNA)
106536view00:01, 6 September 2019KhanspersModified description
105788view19:47, 15 August 2019KhanspersModified description
105316view22:47, 29 July 2019AriuttaHGNC -> HGNC Accession number.
101993view19:22, 22 November 2018EgonwRemoved whitespace in PubMed identifiers and duplicate BioPax content.
101842view20:54, 12 November 2018EgonwFixed the upper case of a Uniprot identifier.
101830view09:45, 12 November 2018EgonwReplaced old Uniprot data sources with the new ones.
96172view14:29, 22 February 2018FehrhartAdded reference for pathway publication
96171view13:26, 22 February 2018FehrhartModified description
96170view13:25, 22 February 2018FehrhartModified description
95733view22:42, 18 January 2018AlexanderPicoupdated to TrEMBL
94984view13:49, 23 October 2017DeSlAdded IDs for GABA-receptor units which where missing, added linkout to GABA signalling PW.
94551view16:11, 25 September 2017EgonwReverted to version '14:42, 5 September 2017' by Egonw
94544view14:14, 22 September 2017Fehrhartcorrected some graphical issues
94543view13:09, 22 September 2017SusanQuick edit to datanode annotation or property
94376view14:42, 5 September 2017Fehrhartannotated interactions
94375view12:48, 5 September 2017Fehrhartchange of presentation of protein complex (LH, FSH)
93046view09:05, 27 July 2017FehrhartConnected interaction
92786view10:03, 6 July 2017KJanssenCorrected 1 interaction type
92755view14:21, 3 July 2017KJanssenEdited the legend and some annotations
92753view12:02, 3 July 2017FehrhartGraphical element conversion
92751view07:20, 3 July 2017FehrhartConversion graphical lines in legend
92732view11:48, 1 July 2017KJanssenCorrected a small mistake
92731view11:39, 1 July 2017KJanssenAdded a figure legend
92684view17:46, 28 June 2017MaintBotfixed unconnected
92679view16:23, 28 June 2017KJanssenMade some minor changes to the layout
92649view10:45, 27 June 2017FehrhartOntology Term : 'Angelman syndrome' added !
92648view10:44, 27 June 2017FehrhartModified description
92629view15:43, 22 June 2017KJanssenModified description
92628view15:39, 22 June 2017KJanssenModified description
92627view15:19, 22 June 2017KJanssenModified title
92611view14:15, 20 June 2017KJanssenAdded a part in the GABRB3 section
92610view12:41, 20 June 2017KJanssenFixed references, as this went wrong with the last update
92609view12:33, 20 June 2017KJanssenAdded a section for SNORD115. Also made some minor changes regarding the layout of the pathway.
92567view12:07, 16 June 2017Mkutmonfixed reference
92566view12:00, 16 June 2017KJanssenOntology Term : 'Prader-Willi syndrome' added !
92565view11:59, 16 June 2017KJanssenOntology Term : 'disease pathway' added !

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ARFGeneProductQ8N726 (Uniprot-SwissProt)
ATP10AGeneProductENSG00000206190 (Ensembl)
ApoptosisPathwayWP254 (WikiPathways)
BBS4GeneProductENSG00000140463 (Ensembl)
BDNF (1-247)ProteinP23560 (Uniprot-SwissProt)
BDNF (129-247)ProteinP23560 (Uniprot-SwissProt)
CCND1ProteinP24385 (Uniprot-SwissProt)
CCND2ProteinP30279 (Uniprot-SwissProt)
CDC6GeneProductQ99741 (Uniprot-SwissProt)
CDK4ProteinP11802 (Uniprot-SwissProt)
CDK6ProteinQ00534 (Uniprot-SwissProt)
CDKN2BProteinP42772 (Uniprot-SwissProt)
CDKN2CProteinP42773 (Uniprot-SwissProt)
CGAGeneProductP01215 (Uniprot-SwissProt)
CYFIP1GeneProductENSG00000273749 (Ensembl)
Ca2+Metabolite
DLX5GeneProductENSG00000105880 (Ensembl)
E2F1GeneProductENSG00000101412 (Ensembl)
Exon IRna
FEZ1GeneProductENSG00000149557 (Ensembl)
FEZ2ProteinENSG00000171055 (Ensembl)
FSHBGeneProductP01225 (Uniprot-SwissProt)
G1/S progressionPathwayWP45 (WikiPathways)
G2/M arrestPathway
GABA(A) receptor subunit deltaGeneProduct
GABA(A) receptor subunit gammaGeneProduct
GABA(A) receptor subunit rhoGeneProduct
GABA(A) receptor subunit alpha-5GeneProductP31644 (Uniprot-SwissProt)
GABA(A) receptor subunit beta-3GeneProductP28472 (Uniprot-SwissProt)
GABRA5GeneProductENSG00000186297 (Ensembl)
GABRB3GeneProductENSG00000166206 (Ensembl)
GABRG3GeneProductENSG00000182256 (Ensembl)
GHRH (1-108)ProteinP01286 (Uniprot-SwissProt)
GHRH (32-75)ProteinP01286 (Uniprot-SwissProt)
GNRH1 (24-33)ProteinP01148 (Uniprot-SwissProt)
GNRH1 (24-92)ProteinP01148 (Uniprot-SwissProt)
GNRH1ProteinP01148 (Uniprot-SwissProt)
Ghrelin (1-117)ProteinQ9UBU3 (Uniprot-SwissProt)
Ghrelin (24-51)ProteinQ9UBU3 (Uniprot-SwissProt)
HERC2GeneProductENSG00000128731 (Ensembl)
HTR2C mRNARnaENSG00000147246 (Ensembl)
HTR2CGeneProductENSG00000147246 (Ensembl)
IIRna
IIIRna
IPWGeneProduct6109 (HGNC)
IVRna
Insulin (25-110)ProteinP01308 (Uniprot-SwissProt)
Insulin (57-87)ProteinP01308 (Uniprot-SwissProt)
Insulin A chain

(90-110)

ProteinP01308 (Uniprot-SwissProt)
Insulin B chain

(25-54)

ProteinP01308 (Uniprot-SwissProt)
Insulin processingPathwayWP2736 (WikiPathways)
KISS1ProteinQ15726 (Uniprot-SwissProt)
L-dopaquinoneMetaboliteCHEBI:16852 (ChEBI)
L-tyrosineMetaboliteCHEBI:58315 (ChEBI)
LHBGeneProductP01229 (Uniprot-SwissProt)
MAGEL2GeneProductENSG00000254585 (Ensembl)
MDM2GeneProductQ00987 (Uniprot-SwissProt)
MDM4GeneProductO15151 (Uniprot-SwissProt)
MKRN3GeneProductENSG00000179455 (Ensembl)
MSX1GeneProductENSG00000163132 (Ensembl)
Melanin biosynthesisPathwayWP3377 (WikiPathways)
NDNGeneProductENSG00000182636 (Ensembl)
NGFGeneProductENSG00000134259 (Ensembl)
NHLH2GeneProductENSG00000177551 (Ensembl)
NIPA1GeneProductENSG00000170113 (Ensembl)
NIPA2GeneProductENSG00000140157 (Ensembl)
NK3RProteinP29371 (Uniprot-SwissProt)
NKBProteinQ2UVB8 (Uniprot-TrEMBL)
NPAP1GeneProductENSG00000185823 (Ensembl)
OCA2GeneProductENSG00000104044 (Ensembl)
Oxytocin (20-28)ProteinP01178 (Uniprot-SwissProt)
Oxytocin-neurophysin 1 (1-125)Proteinp01178 (Uniprot-SwissProt)
P-proteinProteinQ04671 (Uniprot-SwissProt)
PCM1GeneProductENSG00000078674 (Ensembl)
PCSK1GeneProductENSG00000175426 (Ensembl)
POMC (1-241)ProteinP01189 (Uniprot-SwissProt)
POMC (138-176) ProteinP01189 (Uniprot-SwissProt)
PRKCZGeneProductENSG00000067606 (Ensembl)
PWRN1GeneProductENSG00000259905 (Ensembl)
Peptide hormone biosynthesisPathwayWP2691 (WikiPathways)
Proteasome

degradation

pathway		PathwayWP183 (WikiPathways)
RB1ProteinP06400 (Uniprot-SwissProt)
SLC45A2GeneProductENSG00000164175 (Ensembl)
SNORD107GeneProductENSG00000276314 (Ensembl)
SNORD109AGeneProductENSG00000274640 (Ensembl)
SNORD109BGeneProductENSG00000239169 (Ensembl)
SNORD115@GeneProduct692218 (Entrez Gene)
  • SNORD115 primarily regulates alternate splicing of HTR2C pre-mRNA, by binding to the latter.
  • Alternate splicing and adenosine-to-inosine RNA-editing both lead to translation of less functional receptors.
  • Loss of SNORD115 might influence 5-HT2CR regulated appetite, and could therefore contribute to hyperphagia in PWS.
SNORD116@GeneProduct692236 (Entrez Gene)
SNORD64GeneProductENSG00000276610 (Ensembl)
SNRPNGeneProductENSG00000128739 (Ensembl)
SNURF-SNRPNGeneProductENSG00000128739 (Ensembl)
SNURFGeneProductENSG00000273173 (Ensembl)
Signaling pathway in GlioblastomaPathwayWP2261 (WikiPathways)
Spliceosomal A complexComplexR-HSA-72068.3 (Reactome)
Spliceosomal E complexComplexR-HSA-72057.3 (Reactome)
Synthesis, secretion

and deacylation of

ghrelin		PathwayWP3436 (WikiPathways)
TUBGCP5GeneProductENSG00000275835 (Ensembl)
TyrosinaseProteinP14679 (Uniprot-SwissProt)
UBE3AGeneProductENSG00000114062 (Ensembl)
VIRna
VaRna
VbRna
mRNA processing Major splicing pathwayPathwayWP411 (WikiPathways)
p16-INK4aProteinP42771 (Uniprot-SwissProt)
p53ProteinP04637 (Uniprot-SwissProt)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP3998"
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