Histidine, purine, and pyrimidine superpathway (Saccharomyces cerevisiae)
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AMP
phosphoribosyl-ATP
carbamoyl-phosphate
H2O
phosphoribosyl-formamido-carboxamide
histidinol
H2O
histidinal
NAD
H+
THF
H2O
UTP
UMP
phosphoribosyl-carboxy-aminoimidazole
5-phospho-ribosyl-glycineamide
oxidized thioredoxin
oxidized flavodoxin
5-phosphoribosylamine
reduced acceptor
NAD
HCO3
H2O
reduced flavodoxin
5’-phosphoribosyl-5-aminoimidazole
CO2
THF
UDP
dihydroorotate
orotate
reduced thioredoxin
H+
phosphoribosylformiminoAICAR-phosphate
L-aspartate
imidazole acetol-phosphate
H2O
phosphoribulosylformimino-AICAR-P
H2O
D-erythro-imidazole-glycerol-phosphate
H2O
5’-phosphoribosyl-N-formylglycineamide
acceptor
2-oxoglutarate
H+
CTP
deoxy-GTP
H2O
IMP
orotidine-5’-phosphate
AMP
AMP
CO2
H2O
H2O
H2O
NH3
sucinocarboxamide)-5-aminoimidazole
H2O
H2O
fumerate
H2O
H2O
5-phosphoribosyl-n-formylglycineamidine
carbamoyl-L-aspartate
phosphoribosyl-AMP
NAD
L-aspartate
H2O
5’-phosphoribosyl-4-(N-
ADP
10-formyl-THF
ADP
ATP
ATP
xanthosine-5-phosphate
ADE1
ATP
NADH
ADE5,7
HIS4
PRS2
ADE6
RNR4
GTP
PRPP
phosphate
ADP
ATP
L-glutamine
URA2
IMD2
URA4
URA2
PRS1
HIS1
phosphate
RNR3
ADP
AICAR
ATP
HIS4
NADH
L-glutamate
L-glutamate
URA5
2 ADP
ADE16
IMD3
pyrophosphate
phosphate
HIS2
L-glutamine
CDP
ADP
ADE5,7
URA6
ATP
phosphate
phosphate
RNR2
YNK1
ADE17
ADP
RNR1
ATP
ADP
ADE17
PRS5
ADP
ADE13
ATP
ribose-5-phosphate
ADP
phosphate
L-glutamate
ATP
ADE2
ATP
ADP
ADE8
ADE4
L-glutamine
HIS3
HIS4
L-glutamine
phosphate
pyrophosphate
2 ATP
URA3
ATP
dGDP
GUA1
YNK1
L-glutamate
URA10
10-formyl-THF
phosphate
ATP
PRS4
ATP
IMD4
URA8
phosphate
ATP
ATP
ADP
HIS6
ADP
PRS3
HIS5
L-glutamine
phosphate
L-histidinol-phosphate
GUK1
ATP
pyrophosphate
L-histidine
URA7
HIS4
L-glutamate
L-glutamine
URA1
GDP
ADE16
L-glycine
L-glutamate
L-glutamate
NADH
pyrophosphate
GMP
pyrophosphate
Description
No description
Comments
GenMAPP remarks
Based on
http://pathway.yeastgenome.org/biocyc/
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Quality Tags
Ontology Terms
Saving...
No Tags!
Bibliography
''Histidine, purine, and pyrimidine superpathway''; YeastPathways,
History
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Compare
Revision
Action
Time
User
Comment
135544
view
20:00, 23 September 2024
Khanspers
Modified description
135448
view
21:58, 5 September 2024
Khanspers
Ontology Term : 'classic metabolic pathway' added !
135447
view
21:58, 5 September 2024
Khanspers
removed GenMAPP comments
135446
view
21:57, 5 September 2024
Khanspers
135445
view
21:56, 5 September 2024
Khanspers
lit ref
135314
view
00:05, 17 August 2024
Khanspers
interactions
122754
view
05:17, 10 May 2022
Egonw
Added identifiers to water nodes
117345
view
11:53, 20 May 2021
Eweitz
Modified title
107259
view
14:35, 17 September 2019
MaintBot
ChEBI identifier normalization
94664
view
13:18, 4 October 2017
DeSl
Changed ribose-5-P label to D-ribose-5-P
94663
view
13:17, 4 October 2017
DeSl
Connected all lines, changed all textlabels to metabolite nodes, connected all genes to the lines.
93079
view
09:22, 28 July 2017
Elisa
Fixed some of the unconnected interactions (left side of the pathway).
93011
view
14:46, 24 July 2017
DeSl
Changed wrong CAS number (salt) for correct ChEBI ID
85638
view
16:11, 4 June 2016
Egonw
Fixed the CAS number.
71897
view
10:35, 22 October 2013
Mkutmon
changed AICAR from Unknown to Metabolite
70270
view
21:50, 15 July 2013
MaintBot
updated to 2013 schema
69872
view
18:00, 11 July 2013
Egonw
Marked a few DataNodes with CAS registry numbers as metabolites.
67670
view
11:47, 26 June 2013
Ddigles
Ontology Term : 'nucleotide metabolic pathway' added !
41803
view
04:48, 2 March 2011
MaintBot
Removed redundant pathway information and comments
21558
view
11:32, 14 November 2008
MaintBot
[[Pathway:Saccharomyces cerevisiae:Superpathway of Histidine Purine and Pyrimidine Biosynthesis]] moved to [[Pathway:WP416]]: Moved to stable identifier
12861
view
08:06, 17 May 2008
MaintBot
automated metabolite conversion
8948
view
14:13, 7 January 2008
MaintBot
Added to category $category
8946
view
14:13, 7 January 2008
M.Braymer
Uploaded new pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
10-formyl-THF
Metabolite
2800-34-2 (CAS)
2 ADP
Metabolite
58-64-0 (CAS)
2 ATP
Metabolite
1927-31-7 (CAS)
ADE13
GeneProduct
S000004351 (SGD)
ADE16
GeneProduct
S000004018 (SGD)
ADE17
GeneProduct
S000004727 (SGD)
ADE1
GeneProduct
S000000070 (SGD)
ADE2
GeneProduct
S000005654 (SGD)
ADE4
GeneProduct
S000004915 (SGD)
ADE5,7
GeneProduct
S000003203 (SGD)
ADE6
GeneProduct
S000003293 (SGD)
ADE8
GeneProduct
S000002816 (SGD)
ADP
Metabolite
58-64-0 (CAS)
AICAR
Metabolite
3031-94-5 (CAS)
ATP
Metabolite
1927-31-7 (CAS)
CDP
Metabolite
63-38-7 (CAS)
GDP
Metabolite
146-91-8 (CAS)
GMP
Metabolite
85-32-5 (CAS)
GTP
Metabolite
2564-35-4 (CAS)
GUA1
GeneProduct
S000004830 (SGD)
GUK1
GeneProduct
S000001550 (SGD)
HIS1
GeneProduct
S000000857 (SGD)
HIS2
GeneProduct
S000001921 (SGD)
HIS3
GeneProduct
S000005728 (SGD)
HIS4
GeneProduct
S000000535 (SGD)
HIS5
GeneProduct
S000001378 (SGD)
HIS6
GeneProduct
S000001282 (SGD)
IMD2
GeneProduct
S000001259 (SGD)
IMD3
GeneProduct
S000004424 (SGD)
IMD4
GeneProduct
S000004520 (SGD)
L-glutamate
Metabolite
56-86-0 (CAS)
L-glutamine
Metabolite
56-85-9 (CAS)
L-glycine
Metabolite
56-40-6 (CAS)
L-histidine
Metabolite
71-00-1 (CAS)
L-histidinol-phosphate
Metabolite
25679-93-0 (CAS)
NADH
Metabolite
53-84-9 (CAS)
PRPP
Metabolite
97-55-2 (CAS)
PRS1
GeneProduct
S000001664 (SGD)
PRS2
GeneProduct
S000000901 (SGD)
PRS3
GeneProduct
S000001003 (SGD)
PRS4
GeneProduct
S000000164 (SGD)
PRS5
GeneProduct
S000005422 (SGD)
RNR1
GeneProduct
S000000872 (SGD)
RNR2
GeneProduct
S000003563 (SGD)
RNR3
GeneProduct
S000001328 (SGD)
RNR4
GeneProduct
S000003412 (SGD)
URA10
GeneProduct
S000004884 (SGD)
URA1
GeneProduct
S000001699 (SGD)
URA2
GeneProduct
S000003666 (SGD)
URA3
GeneProduct
S000000747 (SGD)
URA4
GeneProduct
S000004412 (SGD)
URA5
GeneProduct
S000004574 (SGD)
URA6
GeneProduct
S000001507 (SGD)
URA7
GeneProduct
S000000135 (SGD)
URA8
GeneProduct
S000003864 (SGD)
YNK1
GeneProduct
S000001550 (SGD)
dGDP
Metabolite
28862 (ChEBI)
phosphate
Metabolite
14265-44-2 (CAS)
pyrophosphate
Metabolite
2466-09-3 (CAS)
ribose-5-phosphate
Metabolite
3615-55-2 (CAS)
xanthosine-5-phosphate
Metabolite
523-98-8 (CAS)
Annotated Interactions
No annotated interactions
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Discussion
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