PI3K/AKT/mTOR - vitamin D3 signaling (Homo sapiens)

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1LDHALactatemTOR TCA CycleVDRAMPKAKT1,25-(OH)2-D3CD86ROSCYP24A1Complex formationC-MYCHLA-DRAHK3Fructose-6-PGlucose-6-PCD80GLUT3Fructose Bisphosphate PI3KRXRGSK-3bTSC1PFKFB4PDHA1PyruvateC-MYCC-MYCC-MYCATPMMPAMP/ATP ratioPFKFB4VDR1,25-(OH)2-D3RXRTSC2Glycolytic enzymesCell cyclep65 translocationIL-10IL-12


Description

No description

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Quality Tags

Ontology Terms

 

Bibliography

  1. Ferreira GB, Vanherwegen AS, Eelen G, Gutiérrez AC, Van Lommel L, Marchal K, Verlinden L, Verstuyf A, Nogueira T, Georgiadou M, Schuit F, Eizirik DL, Gysemans C, Carmeliet P, Overbergh L, Mathieu C; ''Vitamin D3 Induces Tolerance in Human Dendritic Cells by Activation of Intracellular Metabolic Pathways.''; Cell Rep, 2015 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
135057view12:30, 2 August 2024EweitzEconomize layout
122432view11:35, 5 April 2022EweitzModified title
116420view09:10, 7 May 2021EweitzModified title
106775view13:25, 17 September 2019MaintBotHMDB identifier normalization
106551view00:12, 6 September 2019KhanspersModified description
105774view19:40, 15 August 2019KhanspersModified description
98518view18:52, 14 September 2018Khanspersfixed literature reference
98517view18:50, 14 September 2018KhanspersModified description
98505view12:09, 13 September 2018SusanCorrected annotation of the TCA cycle
98474view08:39, 10 September 2018SusanAdded connections
96450view09:29, 15 March 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
95974view10:39, 11 February 2018EgonwMetabolites don't change to genes (but this needs some redrawing anyway).
95854view17:42, 26 January 2018KhanspersModified description
95225view18:39, 26 November 2017DeSlConnected unconnected line.
95171view20:36, 20 November 2017SusanAnnotated metabolites
95170view20:33, 20 November 2017SusanAdded annotations and labels
95147view03:29, 17 November 2017AlexanderPicofixed interactions
94303view11:18, 1 September 2017Marvin M2Changed the unconnected arrows into graphical arrows
94269view12:37, 30 August 2017Madeomuga
94266view12:14, 30 August 2017MadeomugaOntology Term : 'mTOR signaling pathway' added !
94265view12:14, 30 August 2017MadeomugaOntology Term : 'phosphatidylinositol 3-kinase-Akt signaling pathway' added !
94264view12:13, 30 August 2017MadeomugaOntology Term : 'vitamin D signaling pathway' added !
94263view12:11, 30 August 2017Madeomuga
94262view12:01, 30 August 2017Madeomuga
94261view11:49, 30 August 2017MadeomugaModified description
94260view11:48, 30 August 2017Madeomuga
94259view09:49, 30 August 2017MadeomugaModified description
94258view09:48, 30 August 2017MadeomugaAdded literature and description
94257view09:21, 30 August 2017MadeomugaModified title
94256view09:19, 30 August 2017MadeomugaNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
1,25-(OH)2-D3MetaboliteCHEBI:17823 (ChEBI)
AKTGeneProductENSG00000142208 (Ensembl)
AMP/ATP ratioMetabolite
AMPKGeneProductENSG00000162409 (Ensembl)
ATPMetabolite
C-MYCGeneProductENSG00000136997 (Ensembl)
CD80GeneProductENSG00000121594 (Ensembl)
CD86GeneProductENSG00000114013 (Ensembl)
CYP24A1GeneProductENSG00000019186 (Ensembl)
Cell cyclePathwayWP179 (WikiPathways)
Complex formation
Fructose Bisphosphate MetaboliteCHEBI:65056 (ChEBI)
Fructose-6-PMetaboliteCHEBI:42378 (ChEBI)
GLUT3GeneProductENSG00000059804 (Ensembl)
GSK-3bGeneProductENSG00000082701 (Ensembl)
Glucose-6-PMetaboliteCHEBI:4170 (ChEBI)
Glycolytic enzymesProtein
HK3GeneProductENSG00000160883 (Ensembl)
HLA-DRAGeneProductENSG00000204287 (Ensembl)
IL-10Metabolite
IL-12Metabolite
LDHAGeneProductENSG00000134333 (Ensembl)
LactateMetaboliteCHEBI:24996 (ChEBI)
MMPMetabolite
PDHA1GeneProductENSG00000131828 (Ensembl)
PFKFB4GeneProductENSG00000114268 (Ensembl)
PI3KGeneProductENSG00000121879 (Ensembl)
PyruvateMetaboliteCHEBI:15361 (ChEBI)
ROSMetabolite
RXRGeneProductENSG00000186350 (Ensembl)
TCA CyclePathwayWP999 (WikiPathways)
TSC1GeneProductENSG00000165699 (Ensembl)
TSC2GeneProductENSG00000103197 (Ensembl)
VDRGeneProductENSG00000111424 (Ensembl)
mTOR GeneProductENSG00000198793 (Ensembl)
p65 translocationMetabolite

Annotated Interactions

No annotated interactions

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