Tryptophan catabolism leading to NAD+ production (Homo sapiens)

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1, 212122222121112222212Nicotinic acid mononucleotideTryptophan (Trp)Nadsyn13-HAON-methylnicotinamideNicotinic acid adenine dinucleotide (NaAD+)ADP-ribosylNAD+NaprtNmnat15-HTNrk1PBEF3-hydroxyanthranolate dioxygenaseSerotonin/melatonin productionprotein synthesisIDO2-Amino-3-carboxymuconatesemialdehydeNicotinuric acidNMNNAD+-consuming enzymesNRN-formyl kynurenineL-kynurenine3-OH kynurenine (HK)3-OH anthranilic acid (HAA)Quinolinic acid (QA)Nicotinic acid (NA)Nicotinamide11111Kynurenic acid (KA)1Xanthurenic acid (XA)Anthranilic acid (AA)1TDO1AFMIDKATK3HKYNUQPRTKYNUIndoxyl acetic acid (IAA)Nmnat2Nmnat3NamNrk2


Description

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Quality Tags

Ontology Terms

 

Bibliography

  1. Jrad-Lamine A, Henry-Berger J, Gourbeyre P, Damon-Soubeyrand C, Lenoir A, Combaret L, Saez F, Kocer A, Tone S, Fuchs D, Zhu W, Oefner PJ, Munn DH, Mellor AL, Gharbi N, Cadet R, Aitken RJ, Drevet JR; ''Deficient tryptophan catabolism along the kynurenine pathway reveals that the epididymis is in a unique tolerogenic state.''; J Biol Chem, 2011 PubMed Europe PMC Scholia
  2. Belenky P, Bogan KL, Brenner C; ''NAD+ metabolism in health and disease.''; Trends Biochem Sci, 2007 PubMed Europe PMC Scholia
  3. Okamoto H, Okada F, Hayaishi O; ''Kynurenine metabolism in hyperthyroidism. A biochemical basis for the low NAD(P) level in hyperthyroid rat liver.''; J Biol Chem, 1971 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
123510view05:00, 29 July 2022EgonwMade a pathway clickable
95880view15:32, 31 January 2018DeSlIncluded info from ref 3 in PW
95879view15:22, 31 January 2018DeSlAdded ID for serotonin/melatonin production
95878view15:15, 31 January 2018DeSlAdded database for 3-hydroxyanthranilate dioxygenase
95877view15:12, 31 January 2018DeSlAdded ID for 3-hydroxyanthranilate dioxygenase
95876view15:08, 31 January 2018DeSlOntology Term : 'kynurenine metabolic pathway' added !
95875view15:08, 31 January 2018DeSlOntology Term : 'nicotinamide adenine nucleotide utilization pathway' added !
95874view15:08, 31 January 2018DeSlOntology Term : 'nicotinamide adenine dinucleotide metabolic pathway' added !
95873view15:08, 31 January 2018DeSlOntology Term : 'nicotinamide adenine dinucleotide biosynthetic pathway' added !
95872view15:08, 31 January 2018DeSlOntology Term : 'de novo nicotinamide adenine dinucleotide biosynthetic pathway' added !
95871view15:07, 31 January 2018DeSlOntology Term : 'nicotinamide adenine dinucleotide biosynthesis, the salvage pathway' added !
95870view15:07, 31 January 2018DeSlOntology Term : 'tryptophan degradation pathway' added !
95869view15:06, 31 January 2018DeSlAnnotated additional metabolites
95868view15:00, 31 January 2018DeSlModified description
95867view14:54, 31 January 2018DeSlNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
2-Amino-3-carboxymuconate semialdehydeMetabolite
3-HAOProteinP46952 (Uniprot-TrEMBL) 3-hydroxyamino oxidase ( 3HAO )
3-OH anthranilic acid (HAA)MetaboliteQ2823213 (Wikidata)
3-OH kynurenine (HK)MetaboliteQ2815992 (Wikidata)
3-hydroxyanthranolate dioxygenaseProtein
5-HTMetaboliteQ167934 (Wikidata) pre-cursor for serotonin/melatonin
ADP-ribosylMetaboliteQ27074316 (Wikidata) aka ADP ribose
AFMIDProteinQ63HM1 (Uniprot-TrEMBL) formaminase (arylformamidase; AFMID )
Anthranilic acid (AA)MetaboliteQ385140 (Wikidata)
IDOProteinP14902 (Uniprot-TrEMBL) in most cell types
Indoxyl acetic acid (IAA)MetaboliteQ411208 (Wikidata) indol derivative
K3HProteinO15229 (Uniprot-TrEMBL) kynurenine 3-hydroxylase ( K3H ; also known as KMO)
KATProteinQ8N5Z0 (Uniprot-TrEMBL) kynurenine aminotransferase ( KAT ; also known as AADAT)
KYNUProteinQ16719 (Uniprot-TrEMBL) kynureninase
Kynurenic acid (KA)MetaboliteQ642217 (Wikidata) most abundant kynurenines found in caput epididymal tissue
L-kynurenineMetaboliteQ415768 (Wikidata) most abundant kynurenines found in caput epididymal tissue
N-formyl kynurenineMetaboliteQ27104120 (Wikidata)
N-methylnicotinamideMetaboliteQ27088080 (Wikidata)
NAD+Metabolite
NAD+-consuming enzymesProtein
NMNMetaboliteQ27094156 (Wikidata) Nicotinamide Mononucleotide
NRMetaboliteQ3334152 (Wikidata)
  • N-ribosylnicotinamide = NR
  • occurs extracellularly in blood and milk and can be provided in the diet
Nadsyn1ProteinQ6IA69 (Uniprot-TrEMBL) aka glutamine-dependent NAD+ synthetase
NamMetaboliteQ192423 (Wikidata)
NaprtProteinQ6XQN6 (Uniprot-TrEMBL) Na phosphoribosyltransferase
NicotinamideMetaboliteQ192423 (Wikidata)
Nicotinic acid mononucleotideMetaboliteCHEBI:37008 (ChEBI)
Nicotinic acid (NA)MetaboliteQ11324215 (Wikidata) Provided by diet and, potentially, by bacterial degradative pathways in vertebrates
Nicotinic acid adenine dinucleotide (NaAD+)MetaboliteQ905651 (Wikidata) Assuming that NAADP+ is referred to (since the phosphate group is needed for stabilisation).
Nicotinuric acidMetaboliteQ27107528 (Wikidata)
Nmnat1ProteinQ9HAN9 (Uniprot-TrEMBL)
Nmnat2ProteinQ9BZQ4 (Uniprot-TrEMBL)
Nmnat3ProteinQ96T66 (Uniprot-TrEMBL)
Nrk1ProteinQ9NWW6 (Uniprot-TrEMBL) nicotinamide riboside kinases
Nrk2ProteinQ9NPI5 (Uniprot-TrEMBL) nicotinamide riboside kinases
PBEFProteinP43490 (Uniprot-TrEMBL) Nam phosphoribosyltransferase
QPRTProteinQ15274 (Uniprot-TrEMBL) phosphoribosyltransferase
Quinolinic acid (QA)MetaboliteQ411945 (Wikidata)
Serotonin/melatonin productionPathway
TDOProteinP48775 (Uniprot-TrEMBL) in liver cells
Tryptophan (Trp)MetaboliteQ181003 (Wikidata)
Xanthurenic acid (XA)MetaboliteQ5961262 (Wikidata)
protein synthesisPathway

Annotated Interactions

No annotated interactions

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