Regulation of toll-like receptor signaling (Homo sapiens)
From WikiPathways
Description
Toll-like receptors (TLRs) are critical pattern recognition receptors (PRRs) that recognize pathogen-associated molecular patterns (PAMPs), which are conserved and specific molecular "signatures" expressed by pathogens. TLR ligation triggers distinct but shared signaling pathways that lead to effector mechanisms in innate immune responses. TLR specificity and activation are strictly and finely tuned at multiple levels of various signal transduction pathways, resulting in complex signaling platforms. Many molecules, ranging from membrane and cytosol to nuclear, contribute to TLR ligand discrimination or receptor signaling and play different roles in the regulation of TLR responses via different mechanisms, such as cross-regulation, protein modification, helper cofactors, and posttranscriptional and epigenetic regulation. [1] Source
Quality Tags
Ontology Terms
Pathway Ontology : Toll-like receptor signaling pathway
Bibliography
- Qian C, Cao X; ''Regulation of Toll-like receptor signaling pathways in innate immune responses.''; Ann N Y Acad Sci, 2013 PubMed Europe PMC Scholia
- ''Toll-like receptor signaling pathway ''; https://www.kegg.jp/pathway/hsa04620,
- Hemmi H, Kaisho T, Takeuchi O, Sato S, Sanjo H, Hoshino K, Horiuchi T, Tomizawa H, Takeda K, Akira S; ''Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway.''; Nat Immunol, 2002 PubMed Europe PMC Scholia
- Jurk M, Heil F, Vollmer J, Schetter C, Krieg AM, Wagner H, Lipford G, Bauer S; ''Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848.''; Nat Immunol, 2002 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
(anti-viral compounds) | Metabolite | CHEBI:22587 (ChEBI) | |
AKT1 | GeneProduct | 207 (Entrez Gene) | Original kegg element: gene;60;hsa:10000 hsa:207 hsa:208 |
AKT2 | GeneProduct | 208 (Entrez Gene) | Original kegg element: gene;60;hsa:10000 hsa:207 hsa:208 |
AKT3 | GeneProduct | 10000 (Entrez Gene) | Original kegg element: gene;60;hsa:10000 hsa:207 hsa:208 |
Apoptosis | Pathway | WP254 (WikiPathways) | |
BTK | GeneProduct | ENSG00000010671 (Ensembl) | |
CASP8 | GeneProduct | 841 (Entrez Gene) | Original kegg element: gene;87;hsa:841 |
CCL3 | GeneProduct | 6348 (Entrez Gene) | Original kegg element: gene;44;hsa:6348 |
CCL4 | GeneProduct | 6351 (Entrez Gene) | Original kegg element: gene;38;hsa:6351 |
CCL5 | GeneProduct | 6352 (Entrez Gene) | Original kegg element: gene;58;hsa:6352 |
CD14 | GeneProduct | 929 (Entrez Gene) | Original kegg element: gene;84;hsa:929 |
CD180 | GeneProduct | ENSG00000134061 (Ensembl) | |
CD40 | GeneProduct | 958 (Entrez Gene) | Original kegg element: gene;29;hsa:958 |
CD80 | GeneProduct | 941 (Entrez Gene) | Original kegg element: gene;69;hsa:941 |
CD86 | GeneProduct | 942 (Entrez Gene) | Original kegg element: gene;28;hsa:942 |
CHUK | GeneProduct | 1147 (Entrez Gene) | Original kegg element: gene;42;hsa:1147 |
CISH | GeneProduct | ENSG00000114737 (Ensembl) | |
CTNNAL1 | GeneProduct | ENSG00000119326 (Ensembl) | |
CUEDC2 | GeneProduct | ENSG00000107874 (Ensembl) | |
CXCL10 | GeneProduct | 3627 (Entrez Gene) | Original kegg element: gene;25;hsa:3627 |
CXCL11 | GeneProduct | 6373 (Entrez Gene) | Original kegg element: gene;23;hsa:6373 |
CXCL9 | GeneProduct | 4283 (Entrez Gene) | Original kegg element: gene;24;hsa:4283 |
CYLD | GeneProduct | ENSG00000083799 (Ensembl) | |
FADD | GeneProduct | 8772 (Entrez Gene) | Original kegg element: gene;56;hsa:8772 |
FBXW5 | GeneProduct | ENSG00000159069 (Ensembl) | |
FOS | GeneProduct | 2353 (Entrez Gene) | Original kegg element: gene;35;hsa:2353 hsa:3725 |
IFNA10 | GeneProduct | 3446 (Entrez Gene) | Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452 |
IFNA13 | GeneProduct | 3447 (Entrez Gene) | Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452 |
IFNA1 | GeneProduct | 3439 (Entrez Gene) | Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452 |
IFNA14 | GeneProduct | 3448 (Entrez Gene) | Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452 |
IFNA16 | GeneProduct | 3449 (Entrez Gene) | Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452 |
IFNA17 | GeneProduct | 3451 (Entrez Gene) | Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452 |
IFNA21 | GeneProduct | 3452 (Entrez Gene) | Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452 |
IFNA2 | GeneProduct | 3440 (Entrez Gene) | Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452 |
IFNA4 | GeneProduct | 3441 (Entrez Gene) | Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452 |
IFNA5 | GeneProduct | 3442 (Entrez Gene) | Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452 |
IFNA6 | GeneProduct | 3443 (Entrez Gene) | Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452 |
IFNA7 | GeneProduct | 3444 (Entrez Gene) | Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452 |
IFNA8 | GeneProduct | 3445 (Entrez Gene) | Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452 |
IFNAR1 | GeneProduct | 3454 (Entrez Gene) | Original kegg element: gene;49;hsa:3454 hsa:3455 |
IFNAR2 | GeneProduct | 3455 (Entrez Gene) | Original kegg element: gene;49;hsa:3454 hsa:3455 |
IFNB1 | GeneProduct | 3456 (Entrez Gene) | Original kegg element: gene;1;hsa:3456 |
IKBKB | GeneProduct | 3551 (Entrez Gene) | Original kegg element: gene;36;hsa:3551 |
IKBKE | GeneProduct | 9641 (Entrez Gene) | Original kegg element: gene;54;hsa:9641 |
IKBKG | GeneProduct | 8517 (Entrez Gene) | Original kegg element: gene;85;hsa:8517 |
IL12A | GeneProduct | 3592 (Entrez Gene) | Original kegg element: gene;45;hsa:3592 hsa:3593 |
IL12B | GeneProduct | 3593 (Entrez Gene) | Original kegg element: gene;45;hsa:3592 hsa:3593 |
IL1B | GeneProduct | 3553 (Entrez Gene) | Original kegg element: gene;51;hsa:3553 |
IL6 | GeneProduct | 3569 (Entrez Gene) | Original kegg element: gene;57;hsa:3569 |
IL8 | GeneProduct | 3576 (Entrez Gene) | Original kegg element: gene;43;hsa:3576 |
IRAK1 | GeneProduct | 3654 (Entrez Gene) | Original kegg element: gene;41;hsa:3654 |
IRAK2 | GeneProduct | ENSG00000134070 (Ensembl) | |
IRAK3 | GeneProduct | ENSG00000090376 (Ensembl) | |
IRAK4 | GeneProduct | 51135 (Entrez Gene) | Original kegg element: gene;86;hsa:51135 |
IRF3 | GeneProduct | 3661 (Entrez Gene) | Original kegg element: gene;67;hsa:3661 |
IRF5 | GeneProduct | 3663 (Entrez Gene) | Original kegg element: gene;21;hsa:3663 |
IRF7 | GeneProduct | 3665 (Entrez Gene) | Original kegg element: gene;20;hsa:3665 |
Imidazoquinolin | Metabolite | CHEBI:38776 (ChEBI) | |
JUN | GeneProduct | 3725 (Entrez Gene) | Original kegg element: gene;35;hsa:2353 hsa:3725 |
LBP | GeneProduct | 3929 (Entrez Gene) | Original kegg element: gene;77;hsa:3929 |
LY96 | GeneProduct | 23643 (Entrez Gene) | Original kegg element: gene;71;hsa:23643 |
MAP2K1 | GeneProduct | 5604 (Entrez Gene) | Original kegg element: gene;12;hsa:5604 hsa:5605 |
MAP2K2 | GeneProduct | 5605 (Entrez Gene) | Original kegg element: gene;12;hsa:5604 hsa:5605 |
MAP2K3 | GeneProduct | 5606 (Entrez Gene) | Original kegg element: gene;65;hsa:5606 hsa:5608 |
MAP2K4 | GeneProduct | 6416 (Entrez Gene) | Original kegg element: gene;63;hsa:5609 hsa:6416 |
MAP2K6 | GeneProduct | 5608 (Entrez Gene) | Original kegg element: gene;65;hsa:5606 hsa:5608 |
MAP2K7 | GeneProduct | 5609 (Entrez Gene) | Original kegg element: gene;63;hsa:5609 hsa:6416 |
MAP3K7 | GeneProduct | 6885 (Entrez Gene) | Original kegg element: gene;37;hsa:6885 |
MAP3K7IP1 | GeneProduct | 10454 (Entrez Gene) | Original kegg element: gene;59;hsa:10454 |
MAP3K7IP2 | GeneProduct | ENSG00000055208 (Ensembl) | Original kegg element: gene;59;hsa:10454 |
MAP3K7IP3 | GeneProduct | ENSG00000157625 (Ensembl) | Original kegg element: gene;61;hsa:23118 |
MAP3K8 | GeneProduct | 1326 (Entrez Gene) | Original kegg element: gene;13;hsa:1326 |
MAPK10 | GeneProduct | 5602 (Entrez Gene) | Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602 |
MAPK11 | GeneProduct | 5600 (Entrez Gene) | Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300 |
MAPK12 | GeneProduct | 6300 (Entrez Gene) | Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300 |
MAPK13 | GeneProduct | 5603 (Entrez Gene) | Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300 |
MAPK14 | GeneProduct | 1432 (Entrez Gene) | Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300 |
MAPK1 | GeneProduct | 5594 (Entrez Gene) | Original kegg element: gene;11;hsa:5594 hsa:5595 |
MAPK3 | GeneProduct | 5595 (Entrez Gene) | Original kegg element: gene;11;hsa:5594 hsa:5595 |
MAPK8 | GeneProduct | 5599 (Entrez Gene) | Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602 |
MAPK9 | GeneProduct | 5601 (Entrez Gene) | Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602 |
MBL2 | GeneProduct | ENSG00000165471 (Ensembl) | |
MLST8 | GeneProduct | 64223 (Entrez Gene) | |
MYD88 | GeneProduct | 4615 (Entrez Gene) | Original kegg element: gene;47;hsa:4615 |
MYD88s | GeneProduct | ENSG00000172936 (Ensembl) | |
NEU1 | GeneProduct | ENSG00000184494 (Ensembl) | |
NFKB1 | GeneProduct | 4790 (Entrez Gene) | Original kegg element: gene;14;hsa:4790 |
NFKB2 | GeneProduct | 4791 (Entrez Gene) | Original kegg element: gene;10;hsa:4790 hsa:4791 hsa:5970 |
NFKBIA | GeneProduct | 4792 (Entrez Gene) | Original kegg element: gene;64;hsa:4792 |
OTUD5 | GeneProduct | ENSG00000068308 (Ensembl) | |
PELI1 | GeneProduct | ENSG00000197329 (Ensembl) | |
PELI2 | GeneProduct | ENSG00000139946 (Ensembl) | |
PELI3 | GeneProduct | ENSG00000174516 (Ensembl) | |
PIK3CA | GeneProduct | 5290 (Entrez Gene) | Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503 |
PIK3CB | GeneProduct | 5291 (Entrez Gene) | Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503 |
PIK3CD | GeneProduct | 5293 (Entrez Gene) | Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503 |
PIK3CG | GeneProduct | 5294 (Entrez Gene) | Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503 |
PIK3R1 | GeneProduct | 5295 (Entrez Gene) | Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503 |
PIK3R2 | GeneProduct | 5296 (Entrez Gene) | Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503 |
PIK3R3 | GeneProduct | 8503 (Entrez Gene) | Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503 |
PIK3R5 | GeneProduct | 23533 (Entrez Gene) | Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503 |
PLK1 | GeneProduct | ENSG00000166851 (Ensembl) | |
PTPN6 | GeneProduct | ENSG00000111679 (Ensembl) | |
RAC1 | GeneProduct | 5879 (Entrez Gene) | Original kegg element: gene;48;hsa:5879 |
RBCK1 | GeneProduct | ENSG00000125826 (Ensembl) | |
RELA | GeneProduct | 5970 (Entrez Gene) | Original kegg element: gene;10;hsa:4790 hsa:4791 hsa:5970 |
RIPK1 | GeneProduct | 8737 (Entrez Gene) | Original kegg element: gene;17;hsa:8737 |
RNF216 | GeneProduct | ENSG00000011275 (Ensembl) | |
RNF31 | GeneProduct | ENSG00000092098 (Ensembl) | |
RNF41 | GeneProduct | ENSG00000181852 (Ensembl) | |
SARM1 | GeneProduct | ENSG00000004139 (Ensembl) | |
SFTPA1 | GeneProduct | ENSG00000185303 (Ensembl) | |
SFTPD | GeneProduct | ENSG00000133661 (Ensembl) | |
SIGIRR | GeneProduct | ENSG00000185187 (Ensembl) | |
SMAD6 | GeneProduct | ENSG00000137834 (Ensembl) | |
SOCS1 | GeneProduct | ENSG00000185338 (Ensembl) | |
SPP1 | GeneProduct | 6696 (Entrez Gene) | Original kegg element: gene;15;hsa:6696 |
SQSTM1 | GeneProduct | ENSG00000161011 (Ensembl) | |
STAT1 | GeneProduct | 6772 (Entrez Gene) | Original kegg element: gene;62;hsa:6772 |
SYK | GeneProduct | ENSG00000165025 (Ensembl) | |
TBK1 | GeneProduct | 29110 (Entrez Gene) | Original kegg element: gene;52;hsa:29110 |
TICAM1 | GeneProduct | 148022 (Entrez Gene) | Original kegg element: gene;82;hsa:148022 |
TICAM2 (TAG) | GeneProduct | ENSG00000134970 (Ensembl) | |
TICAM2 | GeneProduct | 353376 (Entrez Gene) | Original kegg element: gene;80;hsa:353376 |
TIRAP | GeneProduct | 114609 (Entrez Gene) | Original kegg element: gene;46;hsa:114609 |
TLR1 | GeneProduct | 7096 (Entrez Gene) | Original kegg element: gene;75;hsa:7096 |
TLR2 | GeneProduct | 7097 (Entrez Gene) | Original kegg element: gene;74;hsa:7097 |
TLR2s | GeneProduct | ENSG00000137462 (Ensembl) | |
TLR3 | GeneProduct | 7098 (Entrez Gene) | Original kegg element: gene;73;hsa:7098 |
TLR4 | GeneProduct | 7099 (Entrez Gene) | Original kegg element: gene;79;hsa:7099 |
TLR4s | GeneProduct | ENSG00000136869 (Ensembl) | |
TLR5 | GeneProduct | 7100 (Entrez Gene) | Original kegg element: gene;72;hsa:7100 |
TLR6 | GeneProduct | 10333 (Entrez Gene) | Original kegg element: gene;76;hsa:10333 |
TLR7 | GeneProduct | 51284 (Entrez Gene) | Original kegg element: gene;39;hsa:51284 hsa:51311 |
TLR8 | GeneProduct | 51311 (Entrez Gene) | Original kegg element: gene;39;hsa:51284 hsa:51311 |
TLR9 | GeneProduct | 54106 (Entrez Gene) | Original kegg element: gene;78;hsa:54106 |
TNF | GeneProduct | 7124 (Entrez Gene) | Original kegg element: gene;66;hsa:7124 |
TNFAIP3 | GeneProduct | ENSG00000118503 (Ensembl) | |
TOLLIP | GeneProduct | 54472 (Entrez Gene) | Original kegg element: gene;81;hsa:54472 |
TRAF3 | GeneProduct | 7187 (Entrez Gene) | Original kegg element: gene;16;hsa:7187 |
TRAF6 | GeneProduct | 7189 (Entrez Gene) | Original kegg element: gene;9;hsa:7189 |
TRAFD1 | GeneProduct | ENSG00000135148 (Ensembl) | |
TREM1 | GeneProduct | ENSG00000124731 (Ensembl) | |
Tifa | GeneProduct | ENSG00000145365 (Ensembl) | |
Trim30 | GeneProduct | ||
USP7 | GeneProduct | ENSG00000187555 (Ensembl) | |
ZMYND11 | GeneProduct | ENSG00000015171 (Ensembl) | |
hsa-let-7e | GeneProduct | ||
hsa-let-7e | GeneProduct | ENSG00000198972 (Ensembl) | |
hsa-let-7i (gene) | GeneProduct | ENSG00000199179 (Ensembl) | |
hsa-mir-105-1 | GeneProduct | ENSG00000207957 (Ensembl) | |
hsa-mir-146a | GeneProduct | ENSG00000207936 (Ensembl) | |
hsa-mir-155 | GeneProduct | ENSG00000207795 (Ensembl) | |
hsa-mir-98 | GeneProduct | 407054 (Entrez Gene) |
Annotated Interactions
No annotated interactions