CRD motif and sFRPs influence on Wnt signaling (Danio rerio)

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1Legend:Activation by N-terminal CRD motifEndocytosisEnhanced signalingJNKFz7 receptorpapcsFRP2distinct non-canonical Wnt pathways RhoAFz7aFz7 receptorRor2 receptorWnt5aJNKsFRP2Ror2Fz7 receptorRor2 receptordistinct non-canonical Wnt pathways Activation by extracellular CRD motif EndocytosisFz7bdistinct non-canonical Wnt pathways JNKpapcpapcpapcpapcpapcpapcEndocytosis


Description

New PW on Danio rerio signaling

Comments

 
Study conducted on wild-type zebrafish AB2O3.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Brinkmann EM, Mattes B, Kumar R, Hagemann AI, Gradl D, Scholpp S, Steinbeisser H, Kaufmann LT, Özbek S; ''Secreted Frizzled-related Protein 2 (sFRP2) Redirects Non-canonical Wnt Signaling from Fz7 to Ror2 during Vertebrate Gastrulation.''; J Biol Chem, 2016 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
96496view21:34, 15 March 2018DeSlChanged gene node to textlabel where needed, slight modification of title.
96495view21:32, 15 March 2018DeSlAdded more IDs
96494view21:16, 15 March 2018DeSlOntology Term : 'embryonic stem cell' added !
96492view21:11, 15 March 2018DeSlOntology Term : 'Wnt signaling pathway' added !
96491view21:11, 15 March 2018DeSlModified description
96489view21:08, 15 March 2018DeSlNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Fz7 receptorProtein
Fz7aGeneProductENSDARG00000060004 (Ensembl)
Fz7bGeneProductENSDARG00000027589 (Ensembl)
JNKProtein
RhoAProtein
Ror2Protein
Ror2 receptorProtein
Wnt5aProtein
distinct non-canonical Wnt pathways Pathway
papcProtein
sFRP2Protein

Annotated Interactions

No annotated interactions
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