Purine metabolism and related disorders (Homo sapiens)

From WikiPathways

Revision as of 14:03, 23 March 2018 by DeSl (Talk | contribs)
Jump to: navigation, search
1XMPPNPSAICAribosideXanthine oxidaseFAICARPguanosinedGTPdGDPdATPRRAPRTdADPAMPD1AICARUrateIMPDH12-DeoxyguanosineSuccinyladenosineSAICARP2,8-DihydroxyadeninedGMPATICPRPPINOSINEHPRT1XanthosineAICARPPRPPsADSLGUANINEATP2-DeoxyadenosineGDPAdenosine deaminaseadenineRibose-5-PAdenosineS-AmphetamineGTPGMPDGUOKXanthineAMPADPhypoxanthinePNPPhosphoribosylpyrophosphate synthetase superactivitydAMP2ʼ-deoxyinosinePNPIMPPNPPNPXOPNPXanthine oxidaseRRATICAdenosine deaminasePNP Phosphoribosylpyrophosphate synthetase superactivityAdenylosuccinase deficiencyAICAr transformylase/IMP cyclohydrolase deficiencyAmp deaminase Myoadenylate deaminaseIMP DEHYDROGENASE 1ADENOSINE DEAMINASEPURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCYADENOSINE DEAMINASEPURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCYPURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCYPURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCYPURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCYXANTHINURIA, TYPE II; XAN2XANTHINURIA, TYPE II; XAN2XANTHINURIA, TYPE II; XAN2XANTHINURIA, TYPE II; XAN2XANTHINURIA, TYPE II; XAN2XANTHINURIA, TYPE II; XAN2ADENINE PHOSPHORIBOSYLTRANSFERASE; APRTLESCH-NYHAN SYNDROME; LNSLESCH-NYHAN SYNDROME; LNSHPRT1LESCH-NYHAN SYNDROME; LNSPURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCYMITOCHONDRIAL DNA DEPLETION SYNDROME 3 (HEPATOCEREBRAL TYPE); MTDPS3RIBONUCLEOTIDE REDUCTASE, M2 B; RRM2B


Description

Overview of purine metabolism and related disseases

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

  1. Blau, N., Duran, M., Gibson, K.M., Dionisi-Vici, C.; '''Physician's Guide to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases, Chapter 41''; ISBN 978-3-642-40337-8,, 2014 PubMed Europe PMC Scholia
  2. R. Mendel; ''The Molybdenum Cofactor''; J. Biol. Chem., 2013 PubMed Europe PMC Scholia
  3. Crouch RD, Blobaum AL, Felts AS, Conn PJ, Lindsley CW; ''Species-Specific Involvement of Aldehyde Oxidase and Xanthine Oxidase in the Metabolism of the Pyrimidine-Containing mGlu5-Negative Allosteric Modulator VU0424238 (Auglurant).''; Drug Metab Dispos, 2017 PubMed Europe PMC Scholia
  4. Su, H, Lenardo, M.; ''Chapter 5 Combined Immune Deficiencies''; https://doi.org/10.1016/B978-0-12-405546-9.00005-4, 2014 DOI Scholia

History

View all...
CompareRevisionActionTimeUserComment
134289view05:40, 20 July 2024EgonwRemoved a template comment (and fixed the β character)
128217view03:40, 29 January 2024EweitzStandardize case
128216view03:35, 29 January 2024EweitzSoften disease color
126033view09:50, 29 March 2023DeSlUpdate layout righthand side
126032view09:49, 29 March 2023DeSlUpdated details for xantinuria II (XAN2) and included MOCOS enzyme
124954view08:25, 7 January 2023EgonwFixed the OMIM link patterns
123768view13:38, 12 August 2022DeSlAdded ed. 5 details
123767view13:35, 12 August 2022DeSlAdded lit ref. + inchikey for 6-oxoP (M1), converted AICARP line to graphical line.
120400view09:08, 30 November 2021Fehrhartboxed pathway node
119708view09:01, 5 August 2021DeSlVisualization change
119707view08:56, 5 August 2021DeSlconverted all http to https for OMIM URLs
119706view08:54, 5 August 2021DeSlFixed another OMIM URL
119705view08:53, 5 August 2021DeSlFixed two more OMIM URLs
119702view08:39, 5 August 2021DeSlfixed another OMIM URL (ADA)
119701view08:28, 5 August 2021DeSlUpdated OMIM URL for APRT disorder
119700view07:54, 5 August 2021DeSlAdded ID for auglurant
119283view10:48, 23 June 2021FinterlyAdded ISBN and DOI Biopax Info
111936view09:08, 11 September 2020DeSlModified description
108454view14:06, 20 December 2019DeSlOntology Term : 'disease pathway' added !
108453view14:06, 20 December 2019DeSlModified title
107302view12:23, 19 September 2019DeSlModified description
107301view12:20, 19 September 2019DeSlUpdated layout
107161view14:24, 17 September 2019MaintBotChEBI identifier normalization
106527view23:48, 5 September 2019KhanspersModified description
105796view22:47, 15 August 2019KhanspersModified description
104773view07:31, 13 June 2019JosienlandmanCorrected the identifier for AICA-riboside
104517view13:13, 29 May 2019JosienlandmanCorrected one Rhea identifier and one OMIM number
104472view12:26, 28 May 2019EgonwConverted another interaction to a graphical line.
104448view13:52, 27 May 2019JosienlandmanChanged interaction to graphicalline
104443view07:48, 27 May 2019Josienlandman
104422view10:58, 24 May 2019JosienlandmanComment for 5-PRA and GAR
104419view09:08, 24 May 2019JosienlandmanAdded enzyme ADSS and identifiers
104388view13:15, 23 May 2019JosienlandmanUnconnected line from AMP to IMP
104386view12:49, 23 May 2019JosienlandmanModified the ChEBI for 5-PRA and added a comment to this datanode.
104381view10:37, 23 May 2019JosienlandmanAdded more Rhea identifiers and modified Chebi identifiers
104374view13:01, 22 May 2019JosienlandmanAdded Rhea identifiers to reactions and changed Chebi identifiers
104030view17:42, 25 April 2019IreneHemelModified description
103969view11:03, 18 April 2019JosienlandmanAdded identifier to AICAR
103967view09:09, 18 April 2019JosienlandmanConnected Adenyl-succinate lyase deficiency to the conversion of SAICARP to AICARP
103966view08:45, 18 April 2019IreneHemelRemoved capitals in Guanine name
103964view08:18, 18 April 2019IreneHemelConnected TPMT deficiency to rest of pathway
103963view07:52, 18 April 2019IreneHemelChanged lines for 2 diseases to graphical line
103962view07:50, 18 April 2019IreneHemelChanged layout for reaction from ITP to IMP
103915view15:05, 15 April 2019IreneHemelModified description
103913view15:01, 15 April 2019IreneHemelModified description
103911view14:01, 15 April 2019JosienlandmanAdded Allopurinol, XO inhibitor, to distinguish Xanthinuria type I and type II
103857view11:38, 11 April 2019IreneHemelChanged arrows to conversions
103856view11:36, 11 April 2019IreneHemelAdded two diseases and reactions involved in these
103851view09:42, 11 April 2019DeSlChanged Uniprot Swissprot annotation to Trembl
103847view06:06, 11 April 2019IreneHemelChanged spelling error

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Phosphoribosylpyrophosphate synthetase superactivity300661 (OMIM)
2,8-DihydroxyadenineMetaboliteQ4596812 (Wikidata)
2-DeoxyadenosineMetaboliteCHEBI:17256 (ChEBI)
2-DeoxyguanosineMetaboliteCHEBI:17172 (ChEBI)
2ʼ-deoxyinosineMetaboliteCHEBI:28997 (ChEBI)
ADENINE PHOSPHORIBOSYLTRANSFERASE; APRT102600 (OMIM)
ADENOSINE DEAMINASE608958 (OMIM)
ADPMetaboliteCHEBI:2342 (ChEBI)
ADSLProteinA0A096LNY4 (Uniprot-TrEMBL)
AICARMetaboliteCHEBI:2030 (ChEBI)
AICARPMetaboliteCHEBI:2030 (ChEBI)
AICAr transformylase/IMP cyclohydrolase deficiency608688 (OMIM)
AMPMetaboliteCHEBI:2356 (ChEBI)
AMPD1GeneProductENSG00000116748 (Ensembl)
APRTGeneProductAPRT (HGNC)
ATICGeneProductENSG00000138363 (Ensembl)
ATPMetaboliteCHEBI:30616 (ChEBI)
Adenosine deaminaseProteinF5GYD4 (Uniprot-TrEMBL)
AdenosineMetaboliteCHEBI:2472 (ChEBI)
Adenylosuccinase deficiency608222 (OMIM)
Amp deaminase Myoadenylate deaminase102770 (OMIM)
DGUOKGeneProductENSG00000114956 (Ensembl)
FAICARPMetaboliteCHEBI:18967 (ChEBI)
GDPMetaboliteCHEBI:5212 (ChEBI)
GMPMetaboliteCHEBI:5228 (ChEBI)
GTPMetaboliteCHEBI:37565 (ChEBI)
GUANINEMetaboliteCHEBI:42948 (ChEBI)
HPRT1GeneProductENSG00000165704 (Ensembl)
IMP DEHYDROGENASE 1146690 (OMIM)
IMPMetaboliteCHEBI:17202 (ChEBI)
IMPDH1GeneProductENSG00000106348 (Ensembl)
INOSINEMetaboliteCHEBI:44407 (ChEBI)
LESCH-NYHAN SYNDROME; LNS300322 (OMIM)
MITOCHONDRIAL DNA DEPLETION SYNDROME 3 (HEPATOCEREBRAL TYPE); MTDPS3251880 (OMIM)
PNPGeneProductCHEBI:1913 (ChEBI)
PRPPMetaboliteCHEBI:2121 (ChEBI)
PRPPsGeneProduct2.7.6.1 (Enzyme Nomenclature)
PURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCY613179 (OMIM)
Phosphoribosylpyrophosphate synthetase superactivity311850 (OMIM)
RIBONUCLEOTIDE REDUCTASE, M2 B; RRM2B604712 (OMIM)
RRGeneProduct
Ribose-5-PMetaboliteCHEBI:52742 (ChEBI)
S-AmphetamineMetaboliteCHEBI:4469 (ChEBI)
SAICARPMetabolite
SAICAribosideMetaboliteCHEBI:18319 (ChEBI)
SuccinyladenosineMetaboliteHMDB00912 (HMDB)
UrateMetaboliteCHEBI:9885 (ChEBI)
XANTHINURIA, TYPE II; XAN2278300 (OMIM)
XANTHINURIA, TYPE II; XAN2603592 (OMIM)
XMPMetaboliteCHEBI:10067 (ChEBI)
XOGeneProduct1.17.3.2 (Enzyme Nomenclature)
Xanthine oxidaseGeneProductQ412509 (Wikidata)
XanthineMetaboliteCHEBI:10059 (ChEBI)
XanthosineMetaboliteCHEBI:10066 (ChEBI)
adenineMetaboliteCHEBI:16708 (ChEBI)
dADPMetaboliteCHEBI:10489 (ChEBI)
dAMPMetaboliteCHEBI:10490 (ChEBI)
dATPMetaboliteCHEBI:10491 (ChEBI)
dGDPMetaboliteCHEBI:10495 (ChEBI)
dGMPMetaboliteCHEBI:10496 (ChEBI)
dGTPMetaboliteCHEBI:10497 (ChEBI)
guanosineMetaboliteCHEBI:16750 (ChEBI)
hypoxanthineMetaboliteQ410305 (Wikidata)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP4224"
Personal tools