Disorders of folate metabolism and transport (Homo sapiens)

From WikiPathways

Revision as of 22:46, 22 April 2018 by Andra (Talk | contribs)
Jump to: navigation, search
1Purine MetabolismTHFProton-coupled folate transporterDNA methylationVitamin B12SerineDHFFolic acidBrainFolate receptor alphaL-glutamic acidFormateSAHNH4+SAMMTHFR deficiencyMTHFSGARTHomocysteineGlycineL-histidineFormiminoglutamic acidCO2DNA synthesis5,10-Methylene-THF5-Methyl-THFMethionine5-formimino-THF5,10-Methenyl-THFGARFormyl-GARAICARFAICAR10-Formyl-THF5-Formyl-THFdTMPdUMPAICARTTSFTHFIFTHFDHMSSHMTFITHFCHDHFRMTHFRMTHFD1THFMTHFS deficiencyMTHFD1 deficiencyDHFR deficiencyHeriditary Folate MalabsorptionFolate ReceptorAlpha DeficiencyIntestinesDHFRDHFR deficiencyMTHFD1MTHFD1LiverFolic acid


Description

Folate metabolism and transport

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

  1. Fernando Scaglia, Nenad Blau; ''Disorders of Folate Metabolism and Transport''; Physician's Guide to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic diseases, chapter 10, 2014
  2. Yuxiang Zheng, Lewis C Cantley; ''Toward a better understanding of folate metabolism in health and disease''; J Exp Med ., 2019 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
128548view22:43, 11 February 2024EweitzSoften disease color, standardize case
126062view14:05, 31 March 2023DeSl
124234view09:57, 3 October 2022DeSlOntology Term : 'megaloblastic anemia' added !
124233view09:52, 3 October 2022DeSlUpdated OMIM-ID for MTHFD1 deficiency
124232view09:50, 3 October 2022DeSlOntology Term : 'glutamate formiminotransferase deficiency' added !
124231view09:50, 3 October 2022DeSlOntology Term : 'BH4-deficient hyperphenylalaninemia C' added !
124229view09:47, 3 October 2022DeSlConnected FIGLU-Uria to another interaction
124227view09:33, 3 October 2022DeSlAdded two more disorders not mentioned in the book
124226view09:29, 3 October 2022DeSlAdded comment for FTHFDH
124225view09:27, 3 October 2022DeSlAdded mitochondria drawing for ALDH1L2
124224view09:26, 3 October 2022DeSlAdded last missing disease from chapter, added more rhea IDs and proteins
124223view09:15, 3 October 2022DeSluPDATED SEVERAL PROTEINS AND DISEASES, STARTED ADDING RHEA idS TO INTERACTIONS
124221view08:56, 3 October 2022DeSlAdded legend
124220view08:55, 3 October 2022DeSlConverted GeneProduct MTHFD1 to Protein DataNode
124219view08:53, 3 October 2022DeSlAdded additional conversions from qDHF
124208view09:39, 29 September 2022DeSlAdded new metabolite reaction (qDHF) based on InchiKey
124207view08:35, 29 September 2022DeSlConverted FTHFI to textLabel, since there is no evidence found that this protein is active in humans.
124206view08:33, 29 September 2022DeSlAdded some more enzymes to THF->5,10-M-THF conversion based on lit. ref.
124205view08:18, 29 September 2022DeSlAdded new ref for whole PWM
124204view08:15, 29 September 2022DeSlUpdated interactions from textlabels, added mim-translocation, added rhea ID for SHMT-catalyzed reaction
124203view08:04, 29 September 2022DeSlAdded some more dteails on FTHFI
119256view19:45, 22 June 2021FinterlyAdded ISBN for book citation
117700view12:21, 22 May 2021EweitzModified title
108786view15:33, 29 January 2020DeSlReplaced A0A024RB99 (unreviewed) with P34897 (reviewed) for SHMT Protein
108078view11:47, 28 November 2019FehrhartOntology Term : 'disease pathway' added !
104641view07:16, 7 June 2019JosienlandmanConverted interaction lines to diseases into graphical lines
104021view17:37, 25 April 2019IreneHemelModified description
102719view14:00, 21 January 2019DeSlModified description
102717view13:34, 21 January 2019DeSlModified description
98280view15:56, 15 August 2018DeSlModified description
98279view15:56, 15 August 2018DeSlChanged layout of disease nodes, and layout of right side of PW for readability.
97896view08:35, 21 June 2018Jessev1993Made lay-out changes
97595view09:21, 28 May 2018DeSlModified description
97594view09:11, 28 May 2018DeSlConnected last unconnected line.
97593view09:10, 28 May 2018DeSlAdded last disease, changed layout, created better connections for RDF.
97575view13:31, 25 May 2018DeSlMore layout changes, connected side metabolites where they should have been
97574view12:53, 25 May 2018DeSlChanged layout, added disease IDs.
97295view20:47, 7 May 2018Khanspersconnected interaction
97162view13:22, 2 May 2018Jessev1993Added Pathway annotations
97161view12:18, 2 May 2018Jessev1993updated annotations, replaced unknown nodes with textlabels
97160view08:53, 2 May 2018DeSlOntology Term : 'vitamin B12 deficiency' added !
97159view08:52, 2 May 2018DeSlOntology Term : 'vitamin metabolic disorder' added !
97158view08:51, 2 May 2018DeSlOntology Term : 'central nervous system neuron' added !
97157view08:51, 2 May 2018DeSlOntology Term : 'methylenetetrahydrofolate reductase deficiency pathway' added !
97156view08:50, 2 May 2018DeSlOntology Term : 'cerebral folate receptor alpha deficiency' added !
96956view22:46, 22 April 2018AndraOntology Term : 'folate metabolic pathway' added !
96924view06:09, 20 April 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
96914view13:05, 19 April 2018Jessev1993added data nodes
96891view12:48, 18 April 2018Jessev1993New pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
10-Formyl-THFMetaboliteCHEBI:15637 (ChEBI)
5,10-Methenyl-THFMetaboliteCHEBI:15638 (ChEBI)
5,10-Methylene-THFMetaboliteCHEBI:1989 (ChEBI)
5-Formyl-THFMetaboliteCHEBI:15640 (ChEBI)
5-Methyl-THFMetaboliteCHEBI:15641 (ChEBI)
5-formimino-THFMetaboliteCHEBI:15639 (ChEBI)
AICARMetaboliteCHEBI:2030 (ChEBI)
AICARTProteinP31939 (Uniprot-TrEMBL)
Brain
CO2MetaboliteCHEBI:16526 (ChEBI)
DHFMetaboliteCHEBI:15633 (ChEBI)
DHFR deficiency
DHFRProteinB0YJ76 (Uniprot-TrEMBL)
DNA methylationPathway
DNA synthesisPathway
FAICARMetaboliteCHEBI:18381 (ChEBI)
FITHFCHProteinO95954 (Uniprot-TrEMBL)
FTHFDHProteinO75891 (Uniprot-TrEMBL)
FTHFIProtein
Folate Receptor Alpha Deficiency
Folate receptor alphaProteinP15328 (Uniprot-TrEMBL)
Folic acidMetaboliteCHEBI:27470 (ChEBI)
FormateMetaboliteCHEBI:30751 (ChEBI)
Formiminoglutamic acidMetaboliteHMDB00854 (HMDB)
Formyl-GARMetaboliteCHEBI:18272 (ChEBI)
GARMetaboliteCHEBI:18349 (ChEBI)
GARTProteinC9JKQ7 (Uniprot-TrEMBL)
GlycineMetabolite
Heriditary Folate Malabsorption
HomocysteineMetaboliteCHEBI:17230 (ChEBI)
Intestines
L-glutamic acidMetaboliteCHEBI:16015 (ChEBI)
L-histidineMetaboliteCHEBI:15971 (ChEBI)
Liver
MSProteinQ99707 (Uniprot-TrEMBL)
MTHFD1 deficiency
MTHFD1GeneProductENSG00000100714 (Ensembl)
MTHFR deficiency
MTHFRProteinP42898 (Uniprot-TrEMBL)
MTHFS deficiency
MTHFSProteinENSG00000136371 (Ensembl)
MethionineMetaboliteCHEBI:16643 (ChEBI)
NH4+MetaboliteCHEBI:28938 (ChEBI)
Proton-coupled folate transporterProteinQ96NT5 (Uniprot-TrEMBL)
Purine MetabolismPathway
SAHMetaboliteCHEBI:16680 (ChEBI)
SAMMetaboliteCHEBI:67040 (ChEBI)
SHMTProteinA0A024RB99 (Uniprot-TrEMBL)
SerineMetabolite
THFMetabolite
THFMetaboliteCHEBI:20506 (ChEBI)
TSProteinP04818 (Uniprot-TrEMBL)
Vitamin B12MetaboliteCHEBI:30411 (ChEBI)
dTMPMetaboliteCHEBI:17013 (ChEBI)
dUMPMetaboliteCHEBI:17622 (ChEBI)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP4259"
Personal tools