Nuclear receptors meta-pathway (Homo sapiens)

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6, 49CAR/PXR LigandCAR target genes2GCLMCYP2A6ESR1ME1Co-activatorsFKBP5SLC7A11G6PDAGERNFKB2RGS2NR1H4UGT2B7POU5F1ANKRD1GSTT2FGD4DegradationGGT1EPHA2CES1SLCO2B1FTLABCC2ETNK2PRRG4GPX2PLK2CYP3A7CDC42EP3ALOX5APGPX3SULT2A1Cell proliferationand apoptosisCYP4A11TGFB2ALDH3A1NCOA1CYP2A6MYOFCYP2B6CDKN1CDNAJC7FGFBP1bile acidconjugationGCLCNR3C1SLC2A3ABCB11SLC26A2DNAJC15OtherGSTP1SP1THBDTGFBR2UGT1A7SLC2A8IL12AUGT1A6SRCSLC2A9MGST1SULT1A1HBEGFABCB4SULT2A1TNS4SLC2A14EP300SNAI2PPARAFTH1NAV3CYP4A11PTGS2CYP7A1SRGNSLC10A1CYP3A4MGST2ZIC2CAP2SLC2A7SLC7A5NCOA2CES5AUGT1A4ABCC3PDE4BCYP3A4EGR1SRXN1HGFSEC14L1SLC2A6SPRY1SQSTM1SLC2A11PCK1GSTA1CBR3AMIGO2SMARCA1Cell proliferationand differentiationFGF13UGT1A4JUNSLC2A4JUNBIRC3UGT1A9CCL2NR0B2CYP2C9SLC2A2GADD45BIP6K3SLC27A5PGDSTAT3NR0B2UGT1A3BAATCES4ACES2UGT1A4CYP1A2CYP3A4PPARGC1ACCL20Drug and steroidmetabolismUGT1A1TNFAIP3CYP1A1CYP2B6HSP90AA1ARL5BTGFAPPARAGPAMUGT1A9TGFBR3GPR153IL12BPDK4PDGFBIRS2Bile acid &xenobiotics transportJUNBACOX1CYP7A1PPARGC1ASERTAD2TGFB1CES3TXNGSTA4PPP2R4SERPINB2EDN2IL1BALAS1HSPA1ACYP2C19MGAMPMP2MAFGIFNGSULT2A1TXNRD3SOD3DNAJB1SLC2A12LRRC8ACES3UGT1A7S100PSTOMSREBF1PPP1R14CGSTA3SLC2A5TGFB1BIRC2GCC1ABCC3ABHD2InflammationGPR115NCOA6Bile acidneosynthesisSP1UGT1A1CXCR7SERPINB9TranscriptionfactorsSLC2A13SLC19A2UGT1A9NRG1RXRAPOLKNR0B2ABCC4TranscriptionfactorsDNERSPINK13SMC1AABCG5CBR1NQO1MGST3EPHA3PRDX6ACAA1B3GNT5SERPINA1KAT2BUGT2B4UGT1A3KEAP1SLC2A1ENC1ABCG8NFE2L2HMOX1SCNN1AABCC2PRDX1ANGPTL4PPARDSDPRGSTA2FGF19UGT1A6AKAP13PTGR1ABCB1CYP2A6CYP1B1HSP90AA1TSC22D3MFGE8ADH7NR1H3FASNCPEB4IL11EHHADHMetabolismHSP90AB1EPB41L4BCYP7A1GSTA2CUL1Phase 2metabolismMT1IPIL17BAntioxidantproteinsGSTA5GSRKTN1TXNRD1GSTT1UGT1A3CYP3A5ABCC5MAFFBLVRBCYP8B1NR1I3SLC2A10BHLHE407243635284537363630NR1I373642521281324413628124181236242334283616, 483743375347361283712373837357292837354239729285423633363635436313637365293613LigandDNAJC7HSP90AA1CoregulatorsGenesTATA boxPBREMRXRANR1I3LigandCo-activatorsNCOA1EGFR pathwayEP300UGT1A620, 28, 36AHRRSRC7CDKN1BAIP7CYP1B14, 7, 20, 28, 42UGT1A120, 28, 36ALDH3A142GSTA220, 28AHRJUND27NQO120, 28IGFBP119NFE2L2BAX207JUN17CYP1A2EGFR4, 7, 20, 28, 42HSP90AA1TNFPTGES3IL214HES1ARNT50CDC37CYP1A14, 7, 20, 28, 42AHRARNTAIPSRCSRCCDC37AHRARNTAHRLigandLigandLigandXREGenesTATA boxUGT1A9Hepatocyteproliferation21, 36NR1H321SCP2CPT1A2121APOC321FABP121CCND1PLTP2121DBIAPOA22121CPT221APOA1CYP4A1121ACADM2121CDK4CYP7A12121MYC21mitochondrialomega-oxidationSLC27A121Cholesterolcatabolismperoxisomalbeta-oxidationKLK1521APOA521CDK121CYP8B1PPAR alpha ligand21PPARAGenesTATA boxPPREPPARARXRALigandlipoproteinmetabolismfatty acidtransportmitochondrialbeta-oxidationPXR target genes5, 15SLCO1B115HSP90AA1NR1I2SRPX2NCOA3FOXO111CYP4F12CYP3A41528UGT1A1DNAJC715ABCC415NRIP1UnknownCYP2B6GSTA228PSMC515PPARGC1ANCOA1NCOA2ABCB1NR1I215LigandCoregulatorsGenesTATA boxXRERXRANR1I2LigandAhR LigandCo-activatorsGenesTATA boxNR1I3NR1I2NR3C1RXRA16, 48NR1I3NR1I2NR3C1HSP90AA1GR ligandp23HSP90AA1p23NR3C1HSP90AA126, 33p23NR3C133LigandNR3C133LigandLigandLigandNR3C1NR3C1LigandLigandGREGenesTATA boxNR3C1NR3C1LigandLigandnGRECoregulatorsGR inhibitorytarget genesLXR ligandNR1H3LigandRXRA16, 48PTGES3RXRA16, 48NR1H3CYP2B637CYP2C937GenesTATA boxVDREVDR target genesVDR32, 33LigandRXRACYP3A437VDRVDR ligandRXRAVDRLigandER ligandESR1ESR1LigandLigandGenesTATA boxEREESR1LigandESR1LigandESR138ESR1ESR1LigandLigandCoregulatorsER target genes44GenesTATA boxNR1H3LigandLXRERXRALXR target genes16, 48FXR ligandNR1H423RXRALigandGenesTATA boxNR1H4RXRA23LigandFXREBile aciddetoxification29NR1H423LigandUGT1A4UGT1A636UGT1A936UGT1A33636CYP2C928CYP3A528CYP2C1928SULT2A1ABCC21ABCC337EHHADH37FOXO135Inflammation1125Growth andapoptosis25SignaltransductionOther2525InflammationGrowth andapoptosis25Signaltransduction25Metabolism2525TransportOther25Nuclearreceptors25FXR Target genesOtherGR stimulatorytarget genesMulti-drugresistanceDrug and steroidmetabolismPhase 2metabolismMulti-drugresistanceOtherOtherPhase 2metabolismDrug and steroidmetabolismPhase 2metabolismOtherDrug and steroidmetabolismMulti-drugresistanceTranscriptionfactorsOtherDrug and steroidmetabolismTranscriptionfactorsOtherDrug and steroidmetabolismPPAR alphatarget genesAhR target genesGenesTATA boxRXRALigandARENRF2 targetgenesOther34Phase 1proteinsPhase 2proteins3434GSTM5GSTM1GSTM2GSTM3GSTM4TransportSLC5A234SLC5A1SLC5A4SLC5A10SLC5A9SLC5A6SLC5A11SLC5A12SLC5A3SLC5A7SLC5A8SLC5A5SLC6A2SLC6A1SLC6A4SLC6A11SLC6A9SLC6A6SLC6A13SLC6A14SLC6A3SLC6A7SLC6A8SLC6A5SLC6A16SLC6A15SLC6A18SLC6A20SLC6A17SLC6A19SLC39A2SLC39A1SLC39A4SLC39A10SLC39A9SLC39A6SLC39A11SLC39A12SLC39A3SLC39A7SLC39A8SLC39A5SLC39A13SLC39A14Growth factorsand receptors34NFE2L2NRF2 ligandKEAP1NFE2L2LigandNFE2L2NFE2L2SCD


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Bibliography

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  1. Hayes JD, McMahon M; ''NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer.''; Trends Biochem Sci, 2009 PubMed Europe PMC Scholia
  2. Mueller M, Banning A, Brigelius-Flohé R, Kipp A; ''Nrf2 target genes are induced under marginal selenium-deficiency.''; Genes Nutr, 2010 PubMed Europe PMC Scholia
  3. Pavek P, Dvorak Z; ''Xenobiotic-induced transcriptional regulation of xenobiotic metabolizing enzymes of the cytochrome P450 superfamily in human extrahepatic tissues.''; Curr Drug Metab, 2008 PubMed Europe PMC Scholia
  4. Mandard S, Mueller M, Kersten S; ''Peroxisome proliferator-activated receptor alpha target genes.''; Cell Mol Life Sci, 2004 PubMed Europe PMC Scholia
  5. Echchgadda I, Song CS, Oh T, Ahmed M, De La Cruz IJ, Chatterjee B; ''The xenobiotic-sensing nuclear receptors pregnane X receptor, constitutive androstane receptor, and orphan nuclear receptor hepatocyte nuclear factor 4alpha in the regulation of human steroid-/bile acid-sulfotransferase.''; Mol Endocrinol, 2007 PubMed Europe PMC Scholia
  6. Lindsey S, Papoutsakis ET; ''The aryl hydrocarbon receptor (AHR) transcription factor regulates megakaryocytic polyploidization.''; Br J Haematol, 2011 PubMed Europe PMC Scholia
  7. Hockley SL, Arlt VM, Brewer D, Te Poele R, Workman P, Giddings I, Phillips DH; ''AHR- and DNA-damage-mediated gene expression responses induced by benzo(a)pyrene in human cell lines.''; Chem Res Toxicol, 2007 PubMed Europe PMC Scholia
  8. Gadaleta RM, van Mil SW, Oldenburg B, Siersema PD, Klomp LW, van Erpecum KJ; ''Bile acids and their nuclear receptor FXR: Relevance for hepatobiliary and gastrointestinal disease.''; Biochim Biophys Acta, 2010 PubMed Europe PMC Scholia
  9. Hariparsad N, Chu X, Yabut J, Labhart P, Hartley DP, Dai X, Evers R; ''Identification of pregnane-X receptor target genes and coactivator and corepressor binding to promoter elements in human hepatocytes.''; Nucleic Acids Res, 2009 PubMed Europe PMC Scholia
  10. Rowlands JC, Gustafsson JA; ''Aryl hydrocarbon receptor-mediated signal transduction.''; Crit Rev Toxicol, 1997 PubMed Europe PMC Scholia
  11. Rodriguez-Sosa M, Elizondo G, Lopez-Duran RM, Rivera I, Gonzalez FJ, Vega L; ''Over-production of IFN-gamma and IL-12 in AhR-null mice.''; FEBS Lett, 2005 PubMed Europe PMC Scholia
  12. Drocourt L, Ourlin JC, Pascussi JM, Maurel P, Vilarem MJ; ''Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  13. Sugatani J, Kojima H, Ueda A, Kakizaki S, Yoshinari K, Gong QH, Owens IS, Negishi M, Sueyoshi T; ''The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR.''; Hepatology, 2001 PubMed Europe PMC Scholia
  14. Willson TM, Kliewer SA; ''PXR, CAR and drug metabolism.''; Nat Rev Drug Discov, 2002 PubMed Europe PMC Scholia
  15. Echchgadda I, Song CS, Roy AK, Chatterjee B; ''Dehydroepiandrosterone sulfotransferase is a target for transcriptional induction by the vitamin D receptor.''; Mol Pharmacol, 2004 PubMed Europe PMC Scholia
  16. Bock KW; ''From differential induction of UDP-glucuronosyltransferases in rat liver to characterization of responsible ligand-activated transcription factors, and their multilevel crosstalk in humans.''; Biochem Pharmacol, 2011 PubMed Europe PMC Scholia
  17. Jeon MS, Esser C; ''The murine IL-2 promoter contains distal regulatory elements responsive to the Ah receptor, a member of the evolutionarily conserved bHLH-PAS transcription factor family.''; J Immunol, 2000 PubMed Europe PMC Scholia
  18. Gao H, Faelt S, Sandelin A, Gustafsson JA, Dahlman-Wright K; ''Genome-wide identification of estrogen receptor alpha-binding sites in mouse liver.''; Mol Endocrinol, 2008 PubMed Europe PMC Scholia
  19. Koehle C, Bock KW; ''Coordinate regulation of Phase I and II xenobiotic metabolisms by the Ah receptor and Nrf2.''; Biochem Pharmacol, 2007 PubMed Europe PMC Scholia
  20. Marchand A, Tomkiewicz C, Marchandeau JP, Boitier E, Barouki R, Garlatti M; ''2,3,7,8-Tetrachlorodibenzo-p-dioxin induces insulin-like growth factor binding protein-1 gene expression and counteracts the negative effect of insulin.''; Mol Pharmacol, 2005 PubMed Europe PMC Scholia
  21. Xu RX, Lambert MH, Wisely BB, Warren EN, Weinert EE, Waitt GM, Williams JD, Collins JL, Moore LB, Willson TM, Moore JT; ''A structural basis for constitutive activity in the human CAR/RXRalpha heterodimer.''; Mol Cell, 2004 PubMed Europe PMC Scholia
  22. Handschin C, Meyer UA; ''Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR.''; Arch Biochem Biophys, 2005 PubMed Europe PMC Scholia
  23. Tachibana K, Kobayashi Y, Tanaka T, Tagami M, Sugiyama A, Katayama T, Ueda C, Yamasaki D, Ishimoto K, Sumitomo M, Uchiyama Y, Kohro T, Sakai J, Hamakubo T, Kodama T, Doi T; ''Gene expression profiling of potential peroxisome proliferator-activated receptor (PPAR) target genes in human hepatoblastoma cell lines inducibly expressing different PPAR isoforms.''; Nucl Recept, 2005 PubMed Europe PMC Scholia
  24. Cai Y, Konishi T, Han G, Campwala KH, French SW, Wan YJ; ''The role of hepatocyte RXR alpha in xenobiotic-sensing nuclear receptor-mediated pathways.''; Eur J Pharm Sci, 2002 PubMed Europe PMC Scholia
  25. Maglich JM, Parks DJ, Moore LB, Collins JL, Goodwin B, Billin AN, Stoltz CA, Kliewer SA, Lambert MH, Willson TM, Moore JT; ''Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  26. Drocourt L, Ourlin JC, Pascussi JM, Maurel P, Vilarem MJ; ''Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  27. Cai Y, Konishi T, Han G, Campwala KH, French SW, Wan YJ; ''The role of hepatocyte RXR alpha in xenobiotic-sensing nuclear receptor-mediated pathways.''; Eur J Pharm Sci, 2002 PubMed Europe PMC Scholia
  28. Maglich JM, Parks DJ, Moore LB, Collins JL, Goodwin B, Billin AN, Stoltz CA, Kliewer SA, Lambert MH, Willson TM, Moore JT; ''Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  29. Mandard S, Mueller M, Kersten S; ''Peroxisome proliferator-activated receptor alpha target genes.''; Cell Mol Life Sci, 2004 PubMed Europe PMC Scholia
  30. Krogsdam AM, Nielsen CA, Neve S, Holst D, Helledie T, Thomsen B, Bendixen C, Mandrup S, Kristiansen K; ''Nuclear receptor corepressor-dependent repression of peroxisome-proliferator-activated receptor delta-mediated transactivation.''; Biochem J, 2002 PubMed Europe PMC Scholia
  31. Weiss C, Faust D, Schreck I, Ruff A, Farwerck T, Melenberg A, Schneider S, Oesch-Bartlomowicz B, Zatloukalova J, Vondracek J, Oesch F, Dietrich C; ''TCDD deregulates contact inhibition in rat liver oval cells via Ah receptor, JunD and cyclin A.''; Oncogene, 2008 PubMed Europe PMC Scholia
  32. Wang JC, Derynck MK, Nonaka DF, Khodabakhsh DB, Haqq C, Yamamoto KR; ''Chromatin immunoprecipitation (ChIP) scanning identifies primary glucocorticoid receptor target genes.''; Proc Natl Acad Sci U S A, 2004 PubMed Europe PMC Scholia
  33. Handschin C, Meyer UA; ''Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR.''; Arch Biochem Biophys, 2005 PubMed Europe PMC Scholia
  34. Timsit YE, Negishi M; ''CAR and PXR: the xenobiotic-sensing receptors.''; Steroids, 2007 PubMed Europe PMC Scholia
  35. Vezina CM, Walker NJ, Olson JR; ''Subchronic exposure to TCDD, PeCDF, PCB126, and PCB153: effect on hepatic gene expression.''; Environ Health Perspect, 2004 PubMed Europe PMC Scholia
  36. Smoak KA, Cidlowski JA; ''Mechanisms of glucocorticoid receptor signaling during inflammation.''; Mech Ageing Dev, 2004 PubMed Europe PMC Scholia
  37. Li AC, Glass CK; ''PPAR- and LXR-dependent pathways controlling lipid metabolism and the development of atherosclerosis.''; J Lipid Res, 2004 PubMed Europe PMC Scholia
  38. Banning A, Deubel S, Kluth D, Zhou Z, Brigelius-Flohé R; ''The GI-GPx gene is a target for Nrf2.''; Mol Cell Biol, 2005 PubMed Europe PMC Scholia
  39. Handschin C, Meyer UA; ''Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR.''; Arch Biochem Biophys, 2005 PubMed Europe PMC Scholia
  40. Mimura J, Fujii-Kuriyama Y; ''Functional role of AhR in the expression of toxic effects by TCDD.''; Biochim Biophys Acta, 2003 PubMed Europe PMC Scholia
  41. Nilsson S, Gustafsson J-Å; ''Estrogen receptors: therapies targeted to receptor subtypes.''; Clin Pharmacol Ther, 2011 PubMed Europe PMC Scholia
  42. Han S, Chiang JY; ''Mechanism of vitamin D receptor inhibition of cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes.''; Drug Metab Dispos, 2009 PubMed Europe PMC Scholia
  43. Pascussi JM, Gerbal-Chaloin S, Drocourt L, Maurel P, Vilarem MJ; ''The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors.''; Biochim Biophys Acta, 2003 PubMed Europe PMC Scholia
  44. Haarmann-Stemmann T, Bothe H, Abel J; ''Growth factors, cytokines and their receptors as downstream targets of arylhydrocarbon receptor (AhR) signaling pathways.''; Biochem Pharmacol, 2009 PubMed Europe PMC Scholia
  45. Kodama S, Koike C, Negishi M, Yamamoto Y; ''Nuclear receptors CAR and PXR cross talk with FOXO1 to regulate genes that encode drug-metabolizing and gluconeogenic enzymes.''; Mol Cell Biol, 2004 PubMed Europe PMC Scholia
  46. Maglich JM, Watson J, McMillen PJ, Goodwin B, Willson TM, Moore JT; ''The nuclear receptor CAR is a regulator of thyroid hormone metabolism during caloric restriction.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
  47. Le Vee M, Jouan E, Fardel O; ''Involvement of aryl hydrocarbon receptor in basal and 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced expression of target genes in primary human hepatocytes.''; Toxicol In Vitro, 2010 PubMed Europe PMC Scholia
  48. Hashimoto K, Mori M; ''Crosstalk of thyroid hormone receptor and liver X receptor in lipid metabolism and beyond [Review].''; Endocr J, 2011 PubMed Europe PMC Scholia
  49. Weiss C, Faust D, Duerk H, Kolluri SK, Pelzer A, Schneider S, Dietrich C, Oesch F, Goettlicher M; ''TCDD induces c-jun expression via a novel Ah (dioxin) receptor-mediated p38-MAPK-dependent pathway.''; Oncogene, 2005 PubMed Europe PMC Scholia
  50. Rochette-Egly C, Germain P; ''Dynamic and combinatorial control of gene expression by nuclear retinoic acid receptors (RARs).''; Nucl Recept Signal, 2009 PubMed Europe PMC Scholia
  51. Gadaleta RM, van Mil SW, Oldenburg B, Siersema PD, Klomp LW, van Erpecum KJ; ''Bile acids and their nuclear receptor FXR: Relevance for hepatobiliary and gastrointestinal disease.''; Biochim Biophys Acta, 2010 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
126680view16:51, 11 June 2023EgonwFixed character encoding issues
126012view11:37, 26 March 2023EgonwWrong ligand term
125859view10:46, 13 March 2023DeSlFixed last 'ligand' classified as protein
125858view10:44, 13 March 2023DeSlResolved typo in description
125857view10:43, 13 March 2023DeSlRemoved empty comment from Description
125856view10:42, 13 March 2023DeSlConnected unconnected line
125855view10:41, 13 March 2023DeSlConverted textLabels 'ligand; to DataNode Metabolite, with ChEBI annotation; changed two protein datanodes to metaboliute for ligand.
125833view07:00, 13 March 2023EgonwAdded ChEBI identifiers for ligands
120815view15:30, 11 January 2022SusanOntology Term : 'transcription factor mediated signaling pathway' added !
117808view14:40, 22 May 2021EweitzModified title
115341view14:20, 14 February 2021EgonwMade more pathways clickable
103038view11:54, 2 February 2019MaintBotReplaced an outdated Ensembl identifiers with the new one.
97489view13:23, 23 May 2018Fehrhartlayout
97488view13:17, 23 May 2018Fehrhartadded annotations
97487view13:08, 23 May 2018Fehrhartadded annotations
97484view12:58, 23 May 2018FehrhartModified description
97483view12:56, 23 May 2018Fehrhartadded annotations
97481view12:50, 23 May 2018Fehrhartadded annotations
97480view12:42, 23 May 2018Fehrhartadded annotations
97479view12:35, 23 May 2018Fehrhartadded annotations
97478view12:12, 23 May 2018FehrhartModified description
97477view12:11, 23 May 2018FehrhartModified description
97476view12:07, 23 May 2018Fehrhartall connections done (hopefully)
97475view12:04, 23 May 2018Fehrhartconnections
97474view12:02, 23 May 2018Fehrhartconnections...
97473view12:00, 23 May 2018Fehrhartfixed connections
97472view11:58, 23 May 2018Fehrhartfixed connections
97471view11:56, 23 May 2018Fehrhartfixed connections
97470view11:55, 23 May 2018Fehrhartfixed more connections
97469view11:53, 23 May 2018Fehrhartfixed more connections
97467view09:20, 23 May 2018Fehrhartfixed more connections
97463view08:48, 22 May 2018Fehrhartfixed connections
87959view13:12, 25 July 2016ElisaOntology Term : 'regulatory pathway' added !
83040view04:29, 18 November 2015Mkutmonfixed issue with references
83016view13:30, 17 November 2015FehrhartUpdate of outdated identifiers
79825view08:28, 17 April 2015EgonwFixed the Ensembl data source.
78569view14:50, 7 January 2015MaintBotadded missing graphIds
78210view14:44, 14 December 2014EgonwChanged schema.
78209view14:42, 14 December 2014MaintBotModified title
78095view11:38, 2 December 2014RiannefijtenNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABCB11GeneProductENSG00000073734 (Ensembl)
ABCB1GeneProductENSG00000085563 (Ensembl)
ABCB4GeneProductENSG00000005471 (Ensembl)
ABCC2GeneProductENSG00000023839 (Ensembl)
ABCC3GeneProductENSG00000108846 (Ensembl)
ABCC4GeneProductENSG00000125257 (Ensembl)
ABCC5GeneProductENSG00000114770 (Ensembl)
ABCG5GeneProductENSG00000138075 (Ensembl)
ABCG8GeneProductENSG00000143921 (Ensembl)
ABHD2GeneProductENSG00000140526 (Ensembl)
ACAA1GeneProductENSG00000060971 (Ensembl)
ACADMGeneProductENSG00000117054 (Ensembl)
ACOX1GeneProductENSG00000161533 (Ensembl)
ADH7GeneProductENSG00000196344 (Ensembl)
AGERGeneProductENSG00000204305 (Ensembl)
AHRGeneProductENSG00000106546 (Ensembl)
AHRRGeneProductENSG00000063438 (Ensembl)
AIPGeneProductENSG00000110711 (Ensembl)
AKAP13GeneProductENSG00000170776 (Ensembl)
ALAS1GeneProductENSG00000023330 (Ensembl)
ALDH3A1GeneProductENSG00000108602 (Ensembl)
ALOX5APGeneProductENSG00000132965 (Ensembl)
AMIGO2GeneProductENSG00000139211 (Ensembl)
ANGPTL4GeneProductENSG00000167772 (Ensembl)
ANKRD1GeneProductENSG00000148677 (Ensembl)
APOA1GeneProductENSG00000118137 (Ensembl)
APOA2GeneProductENSG00000158874 (Ensembl)
APOA5GeneProductENSG00000110243 (Ensembl)
APOC3GeneProductENSG00000110245 (Ensembl)
ARL5BGeneProductENSG00000165997 (Ensembl)
ARNTGeneProduct405 (Entrez Gene)
Antioxidant proteinsPathway
B3GNT5GeneProductENSG00000176597 (Ensembl)
BAATGeneProductENSG00000136881 (Ensembl)
BAX GeneProductENSG00000087088 (Ensembl)
BHLHE40GeneProductENSG00000134107 (Ensembl)
BIRC2GeneProductENSG00000110330 (Ensembl)
BIRC3GeneProductENSG00000023445 (Ensembl)
BLVRBGeneProductENSG00000090013 (Ensembl)
Bile acid detoxificationPathway
Bile acid neosynthesisPathway
Bile acid & xenobiotics transportPathway
CAP2GeneProductENSG00000112186 (Ensembl)
CBR1GeneProductENSG00000159228 (Ensembl)
CBR3GeneProductENSG00000159231 (Ensembl)
CCL20GeneProductENSG00000115009 (Ensembl)
CCL2GeneProductENSG00000108691 (Ensembl)
CCND1GeneProductENSG00000110092 (Ensembl)
CDC37GeneProductENSG00000105401 (Ensembl)
CDC42EP3GeneProductENSG00000163171 (Ensembl)
CDK1GeneProductENSG00000170312 (Ensembl)
CDK4GeneProductENSG00000135446 (Ensembl)
CDKN1BGeneProductENSG00000111276 (Ensembl)
CDKN1CGeneProductENSG00000129757 (Ensembl)
CES1GeneProductENSG00000198848 (Ensembl)
CES2GeneProductENSG00000172831 (Ensembl)
CES3GeneProductENSG00000172828 (Ensembl)
CES4AGeneProductENSG00000172824 (Ensembl)
CES5AGeneProductENSG00000159398 (Ensembl)
CPEB4GeneProductENSG00000113742 (Ensembl)
CPT1AGeneProductENSG00000110090 (Ensembl)
CPT2GeneProductENSG00000157184 (Ensembl)
CUL1GeneProductENSG00000055130 (Ensembl)
CXCR7GeneProductENSG00000144476 (Ensembl)
CYP1A1GeneProductENSG00000140465 (Ensembl)
CYP1A2GeneProductENSG00000140505 (Ensembl)
CYP1B1GeneProductENSG00000138061 (Ensembl)
CYP2A6GeneProductENSG00000255974 (Ensembl)
CYP2B6GeneProductENSG00000197408 (Ensembl)
CYP2C19GeneProductENSG00000165841 (Ensembl)
CYP2C9GeneProductENSG00000138109 (Ensembl)
CYP3A4GeneProductENSG00000160868 (Ensembl)
CYP3A5GeneProductENSG00000106258 (Ensembl)
CYP3A7GeneProductENSG00000160870 (Ensembl)
CYP4A11GeneProductENSG00000187048 (Ensembl)
CYP4F12GeneProductENSG00000186204 (Ensembl)
CYP7A1GeneProductENSG00000167910 (Ensembl)
CYP8B1GeneProductENSG00000180432 (Ensembl)
Cell proliferation and apoptosisPathway
Cell proliferation

and differentiation

Pathway
Cholesterol catabolismPathway
Co-activators
DBIGeneProductENSG00000155368 (Ensembl)
DNAJB1GeneProductENSG00000132002 (Ensembl)
DNAJC15GeneProductENSG00000120675 (Ensembl)
DNAJC7GeneProductENSG00000168259 (Ensembl)
DNERGeneProductENSG00000187957 (Ensembl)
DegradationPathway
Drug and steroid metabolismPathway
EDN2GeneProductENSG00000127129 (Ensembl)
EGFR pathwayPathway
EGFRGeneProductENSG00000146648 (Ensembl)
EGR1GeneProductENSG00000120738 (Ensembl)
EHHADHGeneProductENSG00000113790 (Ensembl)
ENC1GeneProductENSG00000171617 (Ensembl)
EP300GeneProductENSG00000100393 (Ensembl)
EPB41L4BGeneProductENSG00000095203 (Ensembl)
EPHA2GeneProductENSG00000142627 (Ensembl)
EPHA3GeneProductENSG00000044524 (Ensembl)
ESR1GeneProductENSG00000091831 (Ensembl)
ETNK2GeneProductENSG00000143845 (Ensembl)
FABP1GeneProductENSG00000163586 (Ensembl)
FASNGeneProductENSG00000169710 (Ensembl)
FGD4GeneProductENSG00000139132 (Ensembl)
FGF13GeneProductENSG00000129682 (Ensembl)
FGF19GeneProductENSG00000162344 (Ensembl)
FGFBP1GeneProductENSG00000137440 (Ensembl)
FKBP5GeneProductENSG00000096060 (Ensembl)
FOXO1GeneProductENSG00000150907 (Ensembl)
FTH1GeneProductENSG00000167996 (Ensembl)
FTLGeneProductENSG00000087086 (Ensembl)
G6PDGeneProductENSG00000160211 (Ensembl)
GADD45BGeneProductENSG00000099860 (Ensembl)
GCC1GeneProductENSG00000179562 (Ensembl)
GCLCGeneProductENSG00000001084 (Ensembl)
GCLMGeneProductENSG00000023909 (Ensembl)
GGT1GeneProductENSG00000100031 (Ensembl)
GPAMGeneProductENSG00000119927 (Ensembl)
GPR115GeneProductENSG00000153294 (Ensembl)
GPR153GeneProductENSG00000158292 (Ensembl)
GPX2GeneProductENSG00000176153 (Ensembl)
GPX3GeneProductENSG00000211445 (Ensembl)
GSRGeneProductENSG00000104687 (Ensembl)
GSTA1GeneProductENSG00000243955 (Ensembl)
GSTA2GeneProductENSG00000244067 (Ensembl)
GSTA3GeneProductENSG00000174156 (Ensembl)
GSTA4GeneProductENSG00000170899 (Ensembl)
GSTA5GeneProductENSG00000182793 (Ensembl)
GSTM1GeneProductENSG00000134184 (Ensembl)
GSTM2GeneProductENSG00000213366 (Ensembl)
GSTM3GeneProductENSG00000134202 (Ensembl)
GSTM4GeneProductENSG00000168765 (Ensembl)
GSTM5GeneProductENSG00000134201 (Ensembl)
GSTP1GeneProductENSG00000084207 (Ensembl)
GSTT1GeneProductENSG00000277656 (Ensembl)
GSTT2GeneProductENSG00000099984 (Ensembl)
Growth and apoptosisPathway
Growth factors and receptorsPathway
HBEGFGeneProductENSG00000113070 (Ensembl)
HES1GeneProductENSG00000114315 (Ensembl)
HGFGeneProductENSG00000019991 (Ensembl)
HMOX1GeneProductENSG00000100292 (Ensembl)
HSP90AA1 GeneProductENSG00000080824 (Ensembl)
HSP90AA1GeneProductENSG00000080824 (Ensembl)
HSP90AB1GeneProductENSG00000096384 (Ensembl)
HSPA1AGeneProductENSG00000204389 (Ensembl)
Hepatocyte proliferationPathwayin mice (possibly also in humans?)
IFNGGeneProductENSG00000111537 (Ensembl)
IGFBP1 GeneProductENSG00000146678 (Ensembl)
IL11GeneProductENSG00000095752 (Ensembl)
IL12AGeneProductENSG00000168811 (Ensembl)
IL12BGeneProductENSG00000113302 (Ensembl)
IL17BGeneProductENSG00000127743 (Ensembl)
IL1BGeneProductENSG00000125538 (Ensembl)
IL2 GeneProductENSG00000109471 (Ensembl)
IP6K3GeneProductENSG00000161896 (Ensembl)
IRS2GeneProductENSG00000185950 (Ensembl)
InflammationPathway
JUNBGeneProductENSG00000171223 (Ensembl)
JUNDGeneProductENSG00000130522 (Ensembl)
JUNGeneProductENSG00000177606 (Ensembl)
KAT2BGeneProductENSG00000114166 (Ensembl)
KEAP1GeneProductENSG00000079999 (Ensembl)
KLK15GeneProductENSG00000174562 (Ensembl)
KTN1GeneProductENSG00000126777 (Ensembl)
LRRC8AGeneProductENSG00000136802 (Ensembl)
Ligand
Ligand ProteinOmeprazole, TCDD, PCB
MAFFGeneProductENSG00000185022 (Ensembl)
MAFGGeneProductENSG00000197063 (Ensembl)
ME1GeneProductENSG00000065833 (Ensembl)
MFGE8GeneProductENSG00000140545 (Ensembl)
MGAMGeneProductENSG00000179087 (Ensembl)
MGST1GeneProductENSG00000008394 (Ensembl)
MGST2GeneProductENSG00000085871 (Ensembl)
MGST3GeneProductENSG00000143198 (Ensembl)
MT1IPGeneProduct644314 (Entrez Gene)
MYCGeneProductENSG00000136997 (Ensembl)
MYOFGeneProductENSG00000138119 (Ensembl)
MetabolismPathway
Multi-drug resistancePathway
NAV3GeneProductENSG00000067798 (Ensembl)
NCOA1GeneProductENSG00000084676 (Ensembl)
NCOA2GeneProductENSG00000140396 (Ensembl)
NCOA3GeneProductENSG00000124151 (Ensembl)
NCOA6GeneProductENSG00000198646 (Ensembl)
NFE2L2GeneProductENSG00000116044 (Ensembl)
NFKB2GeneProductENSG00000077150 (Ensembl)
NQO1GeneProductENSG00000181019 (Ensembl)
NR0B2GeneProductENSG00000131910 (Ensembl)
NR1H3GeneProductENSG00000025434 (Ensembl)
NR1H4GeneProductENSG00000012504 (Ensembl)
NR1I2GeneProductENSG00000144852 (Ensembl)
NR1I3GeneProductENSG00000143257 (Ensembl)
NR3C1GeneProductENSG00000113580 (Ensembl)
NRG1GeneProductENSG00000157168 (Ensembl)
NRIP1GeneProductENSG00000180530 (Ensembl)
Nuclear receptorsPathway
OtherPathway
PCK1GeneProductENSG00000124253 (Ensembl)
PDE4BGeneProductENSG00000184588 (Ensembl)
PDGFBGeneProductENSG00000100311 (Ensembl)
PDK4GeneProductENSG00000004799 (Ensembl)
PGDGeneProductENSG00000142657 (Ensembl)
PLK2GeneProductENSG00000145632 (Ensembl)
PLTPGeneProductENSG00000100979 (Ensembl)
PMP2GeneProductENSG00000147588 (Ensembl)
POLKGeneProductENSG00000122008 (Ensembl)
POU5F1GeneProductENSG00000204531 (Ensembl)
PPAR alpha ligand
PPARAGeneProductENSG00000186951 (Ensembl)
PPARDGeneProductENSG00000112033 (Ensembl)
PPARGC1AGeneProductENSG00000109819 (Ensembl)
PPP1R14CGeneProductENSG00000198729 (Ensembl)
PPP2R4GeneProductENSG00000119383 (Ensembl) plays a role in translocation of CAR
PRDX1GeneProductENSG00000117450 (Ensembl)
PRDX6GeneProductENSG00000117592 (Ensembl)
PRRG4GeneProductENSG00000135378 (Ensembl)
PSMC5GeneProductENSG00000087191 (Ensembl)
PTGES3GeneProductENSG00000110958 (Ensembl)
PTGR1GeneProductENSG00000106853 (Ensembl)
PTGS2GeneProductENSG00000073756 (Ensembl)
Phase 1

proteins

Pathway
Phase 2 metabolismPathway
Phase 2

proteins

Pathway
RGS2GeneProductENSG00000116741 (Ensembl)
RXRAGeneProductENSG00000186350 (Ensembl)
S100PGeneProductENSG00000163993 (Ensembl)
SCDGeneProductENSG00000099194 (Ensembl)
SCNN1AGeneProductENSG00000111319 (Ensembl)
SCP2GeneProductENSG00000116171 (Ensembl)
SDPRGeneProductENSG00000168497 (Ensembl)
SEC14L1GeneProductENSG00000129657 (Ensembl)
SERPINA1GeneProductENSG00000197249 (Ensembl)
SERPINB2GeneProductENSG00000197632 (Ensembl)
SERPINB9GeneProductENSG00000170542 (Ensembl)
SERTAD2GeneProductENSG00000179833 (Ensembl)
SLC10A1GeneProductENSG00000100652 (Ensembl) inhibition
SLC19A2GeneProductENSG00000117479 (Ensembl)
SLC26A2GeneProductENSG00000155850 (Ensembl)
SLC27A1GeneProductENSG00000130304 (Ensembl)
SLC27A5GeneProductENSG00000083807 (Ensembl)
SLC2A10GeneProductENSG00000197496 (Ensembl)
SLC2A11GeneProductENSG00000133460 (Ensembl)
SLC2A12GeneProductENSG00000146411 (Ensembl)
SLC2A13GeneProductENSG00000151229 (Ensembl)
SLC2A14GeneProductENSG00000173262 (Ensembl)
SLC2A1GeneProductENSG00000117394 (Ensembl)
SLC2A2GeneProductENSG00000163581 (Ensembl)
SLC2A3GeneProductENSG00000059804 (Ensembl)
SLC2A4GeneProductENSG00000181856 (Ensembl)
SLC2A5GeneProductENSG00000142583 (Ensembl)
SLC2A6GeneProductENSG00000160326 (Ensembl)
SLC2A7GeneProductENSG00000197241 (Ensembl)
SLC2A8GeneProductENSG00000136856 (Ensembl)
SLC2A9GeneProductENSG00000109667 (Ensembl)
SLC39A10GeneProductENSG00000196950 (Ensembl)
SLC39A11GeneProductENSG00000133195 (Ensembl)
SLC39A12GeneProductENSG00000148482 (Ensembl)
SLC39A13GeneProductENSG00000165915 (Ensembl)
SLC39A14GeneProductENSG00000104635 (Ensembl)
SLC39A1GeneProductENSG00000143570 (Ensembl)
SLC39A2GeneProductENSG00000165794 (Ensembl)
SLC39A3GeneProductENSG00000141873 (Ensembl)
SLC39A4GeneProductENSG00000147804 (Ensembl)
SLC39A5GeneProductENSG00000139540 (Ensembl)
SLC39A6GeneProductENSG00000141424 (Ensembl)
SLC39A7GeneProductENSG00000112473 (Ensembl)
SLC39A8GeneProductENSG00000138821 (Ensembl)
SLC39A9GeneProductENSG00000029364 (Ensembl)
SLC5A10GeneProductENSG00000154025 (Ensembl)
SLC5A11GeneProductENSG00000158865 (Ensembl)
SLC5A12GeneProductENSG00000148942 (Ensembl)
SLC5A1GeneProductENSG00000100170 (Ensembl)
SLC5A2GeneProductENSG00000140675 (Ensembl)
SLC5A3GeneProductENSG00000198743 (Ensembl)
SLC5A4GeneProductENSG00000100191 (Ensembl)
SLC5A5GeneProductENSG00000105641 (Ensembl)
SLC5A6GeneProductENSG00000138074 (Ensembl)
SLC5A7GeneProductENSG00000115665 (Ensembl)
SLC5A8GeneProductENSG00000256870 (Ensembl)
SLC5A9GeneProductENSG00000117834 (Ensembl)
SLC6A11GeneProductENSG00000132164 (Ensembl)
SLC6A13GeneProductENSG00000010379 (Ensembl)
SLC6A14GeneProductENSG00000268104 (Ensembl)
SLC6A15GeneProductENSG00000072041 (Ensembl)
SLC6A16GeneProductENSG00000063127 (Ensembl)
SLC6A17GeneProductENSG00000197106 (Ensembl)
SLC6A18GeneProductENSG00000164363 (Ensembl)
SLC6A19GeneProductENSG00000174358 (Ensembl)
SLC6A1GeneProductENSG00000157103 (Ensembl)
SLC6A20GeneProductENSG00000163817 (Ensembl)
SLC6A2GeneProductENSG00000103546 (Ensembl)
SLC6A3GeneProductENSG00000142319 (Ensembl)
SLC6A4GeneProductENSG00000108576 (Ensembl)
SLC6A5GeneProductENSG00000165970 (Ensembl)
SLC6A6GeneProductENSG00000131389 (Ensembl)
SLC6A7GeneProductENSG00000011083 (Ensembl)
SLC6A8GeneProductENSG00000130821 (Ensembl)
SLC6A9GeneProductENSG00000196517 (Ensembl)
SLC7A11GeneProductENSG00000151012 (Ensembl)
SLC7A5GeneProductENSG00000103257 (Ensembl)
SLCO1B1GeneProductENSG00000134538 (Ensembl)
SLCO2B1GeneProductENSG00000137491 (Ensembl) inhibition
SMARCA1GeneProductENSG00000102038 (Ensembl)
SMC1AGeneProductENSG00000072501 (Ensembl)
SNAI2GeneProductENSG00000019549 (Ensembl)
SOD3GeneProductENSG00000109610 (Ensembl)
SP1GeneProductENSG00000185591 (Ensembl)
SPINK13GeneProductENSG00000214510 (Ensembl)
SPRY1GeneProductENSG00000164056 (Ensembl)
SQSTM1GeneProductENSG00000161011 (Ensembl)
SRC GeneProductENSG00000197122 (Ensembl)
SRC GeneProductENSG00000197122 (Ensembl)
SRCGeneProductENSG00000197122 (Ensembl)
SREBF1GeneProductENSG00000072310 (Ensembl)
SRGNGeneProductENSG00000122862 (Ensembl)
SRPX2GeneProductENSG00000102359 (Ensembl)
SRXN1GeneProductENSG00000172070 (Ensembl)
STAT3GeneProductENSG00000168610 (Ensembl)
STOMGeneProductENSG00000148175 (Ensembl)
SULT1A1GeneProductENSG00000196502 (Ensembl) during fasting
SULT2A1GeneProductENSG00000105398 (Ensembl)
Signal transductionPathway
TGFAGeneProductENSG00000163235 (Ensembl)
TGFB1GeneProductENSG00000105329 (Ensembl)
TGFB2GeneProductENSG00000092969 (Ensembl)
TGFBR2GeneProductENSG00000163513 (Ensembl)
TGFBR3GeneProductENSG00000069702 (Ensembl)
THBDGeneProductENSG00000178726 (Ensembl)
TNF GeneProductENSG00000232810 (Ensembl)
TNFAIP3GeneProductENSG00000118503 (Ensembl)
TNS4GeneProductENSG00000131746 (Ensembl)
TSC22D3GeneProductENSG00000157514 (Ensembl)
TXNGeneProductENSG00000136810 (Ensembl)
TXNRD1GeneProductENSG00000198431 (Ensembl)
TXNRD3GeneProductENSG00000197763 (Ensembl)
Transcription factorsPathway
TransportPathway
UGT1A1GeneProductENSG00000241635 (Ensembl)
UGT1A3GeneProductENSG00000243135 (Ensembl)
UGT1A4GeneProductENSG00000244474 (Ensembl)
UGT1A6GeneProductENSG00000167165 (Ensembl)
UGT1A7GeneProductENSG00000244122 (Ensembl)
UGT1A9GeneProductENSG00000241119 (Ensembl)
UGT2B4GeneProductENSG00000156096 (Ensembl)
UGT2B7GeneProductENSG00000171234 (Ensembl)
Unknown
VDRGeneProductENSG00000111424 (Ensembl)
ZIC2GeneProductENSG00000043355 (Ensembl)
bile acid conjugationPathway
fatty acid transportPathway
lipoprotein metabolismPathway
mitochondrial beta-oxidationPathway
mitochondrial omega-oxidationPathway
p23GeneProductENSG00000110958 (Ensembl)
peroxisomal beta-oxidationPathway

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP2882"
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