Ebola virus infection in host (Homo sapiens)

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26634171536519Filamin AITGA2CLEC10AASGR1ADAM17ICAM2ICAM3RHOBCD209CLEC4MHAVCR1MHC1GAS6TYRO3ITGA3ITGA4ITGA5ITGA1ITGA6ITGB1ITGB3BST2RAB7ACell MembraneRAB5ANPC1NPC2CTSBCTSLLysosomeNucleusAXLMERTKIKBKEIRF7KPNA1CLEC4GVP35VP24IQGAP1VP40TBK1EBOLAC1QBPTLR4TIMD4VIRUS'RNATPCN2TSG101STAT1NEDD4SOCS3PIK3RCDC42Trans-InfectionMHC2Macropinocytosis24IRF3Interferon Response23Exit of Secreted GPAssembly and BuddingCLATHRINITGAVsGPCytokine Signal343524122CLEC6AMBL2GP1,244441811357CAVEOLINFOLR1RHOC1181202025ssGPTranscription, Traduction and ReplicationVP30Cell AdhesionImmune Surveillance LNPLopes, E. N. 2017Endosome44Fusion toCleave EnvelopeFusion to Ebola's GPChanges the pH19331013211919GP2733RAC193229EGFR29Exit byAKT1MFGE83636CD300A36PRKRA36DDX5822HAVCR222IL438DAB2IPTFAP2ARAB9AEIF2AK228EIF2S130VPS33A30VPS18VPS39VPS41VPS11VPS16NFKBVPS4AdsRNA20EPS151414ERK14RASA2RHOAGELSOLIN26ACTINActin CytoskeletonEP300CREBBP343434CDC44F-ACTINFILAMINPAK13939TIAM17VAV2IGF1R26CLTC37CLTACLTBCLTCL1CAV1CAV2CAV3PIK3R1PIK3CAPIK3CBPIK3CDPIK3R3PIK3R2IsoformsPP1LC8TOP1FLNAFLNBFLNCGSNSCINMAPK1MAPK3NFKB1NFKB2RELRELAACTN1ACTN4ACTBACTG1HLA-AHLA-BHLA-CHLA-DMAHLA-DMBHLA-DOAHLA-DOBHLA-DPA1HLA-EHLA-FHLA-GHLA-DPB1HLA-DQA1HLA-DQA2HLA-DQB1HLA-DQB2HLA-DRAHLA-DRB1HLA-DRB3HLA-DRB4HLA-DRB566342234313173343321313131966137182019136421172127262117234137131361366632626613131362206661322422243222262226666261361010202110101010101010101010101010101010510101010131344333342342342642564622264RELB13EBOLAEBOLAPtdSerGP3916Filamin B31Filamin C


Description

Study of Ebola interaction with human proteins. The direction of the representation is drawn from left to right. The numbers on the circles are relative study data on the evolutionary levels (provisional data).

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Bibliography

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  6. Luthra P, Ramanan P, Mire CE, Weisend C, Tsuda Y, Yen B, Liu G, Leung DW, Geisbert TW, Ebihara H, Amarasinghe GK, Basler CF; ''Mutual antagonism between the Ebola virus VP35 protein and the RIG-I activator PACT determines infection outcome.''; Cell Host Microbe, 2013 PubMed Europe PMC Scholia
  7. Lu J, Qu Y, Liu Y, Jambusaria R, Han Z, Ruthel G, Freedman BD, Harty RN; ''Host IQGAP1 and Ebola virus VP40 interactions facilitate virus-like particle egress.''; J Virol, 2013 PubMed Europe PMC Scholia
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  13. Reid SP, Leung LW, Hartman AL, Martinez O, Shaw ML, Carbonnelle C, Volchkov VE, Nichol ST, Basler CF; ''Ebola virus VP24 binds karyopherin alpha1 and blocks STAT1 nuclear accumulation.''; J Virol, 2006 PubMed Europe PMC Scholia
  14. Chan SY, Empig CJ, Welte FJ, Speck RF, Schmaljohn A, Kreisberg JF, Goldsmith MA; ''Folate receptor-alpha is a cofactor for cellular entry by Marburg and Ebola viruses.''; Cell, 2001 PubMed Europe PMC Scholia
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  16. Esteves GH, Simoes AC, Souza E, Dias RA, Ospina R, Venancio TM; ''New insights about host response to smallpox using microarray data.''; BMC Syst Biol, 2007 PubMed Europe PMC Scholia
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  24. Brudner M, Karpel M, Lear C, Chen L, Yantosca LM, Scully C, Sarraju A, Sokolovska A, Zariffard MR, Eisen DP, Mungall BA, Kotton DN, Omari A, Huang IC, Farzan M, Takahashi K, Stuart L, Stahl GL, Ezekowitz AB, Spear GT, Olinger GG, Schmidt EV, Michelow IC; ''Lectin-dependent enhancement of Ebola virus infection via soluble and transmembrane C-type lectin receptors.''; PLoS One, 2013 PubMed Europe PMC Scholia
  25. Panchal RG, Ruthel G, Kenny TA, Kallstrom GH, Lane D, Badie SS, Li L, Bavari S, Aman MJ; ''In vivo oligomerization and raft localization of Ebola virus protein VP40 during vesicular budding.''; Proc Natl Acad Sci U S A, 2003 PubMed Europe PMC Scholia
  26. Quinn K, Brindley MA, Weller ML, Kaludov N, Kondratowicz A, Hunt CL, Sinn PL, McCray PB Jr, Stein CS, Davidson BL, Flick R, Mandell R, Staplin W, Maury W, Chiorini JA; ''Rho GTPases modulate entry of Ebola virus and vesicular stomatitis virus pseudotyped vectors.''; J Virol, 2009 PubMed Europe PMC Scholia
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  28. Gramberg T, Hofmann H, Moller P, Lalor PF, Marzi A, Geier M, Krumbiegel M, Winkler T, Kirchhoff F, Adams DH, Becker S, Munch J, Pohlmann S; ''LSECtin interacts with filovirus glycoproteins and the spike protein of SARS coronavirus.''; Virology, 2005 PubMed Europe PMC Scholia
  29. Dolnik O, Volchkova V, Garten W, Carbonnelle C, Becker S, Kahnt J, Stroher U, Klenk HD, Volchkov V; ''Ectodomain shedding of the glycoprotein GP of Ebola virus.''; EMBO J, 2004 PubMed Europe PMC Scholia
  30. Jemielity S, Wang JJ, Chan YK, Ahmed AA, Li W, Monahan S, Bu X, Farzan M, Freeman GJ, Umetsu DT, Dekruyff RH, Choe H; ''TIM-family proteins promote infection of multiple enveloped viruses through virion-associated phosphatidylserine.''; PLoS Pathog, 2013 PubMed Europe PMC Scholia
  31. Yuan S, Cao L, Ling H, Dang M, Sun Y, Zhang X, Chen Y, Zhang L, Su D, Wang X, Rao Z; ''TIM-1 acts a dual-attachment receptor for Ebolavirus by interacting directly with viral GP and the PS on the viral envelope.''; Protein Cell, 2015 PubMed Europe PMC Scholia
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  35. Carette JE, Raaben M, Wong AC, Herbert AS, Obernosterer G, Mulherkar N, Kuehne AI, Kranzusch PJ, Griffin AM, Ruthel G, Dal Cin P, Dye JM, Whelan SP, Chandran K, Brummelkamp TR; ''Ebola virus entry requires the cholesterol transporter Niemann-Pick C1.''; Nature, 2011 PubMed Europe PMC Scholia
  36. Dominguez-Soto A, Aragoneses-Fenoll L, Martin-Gayo E, Martinez-Prats L, Colmenares M, Naranjo-Gomez M, Borras FE, Munoz P, Zubiaur M, Toribio ML, Delgado R, Corbi AL; ''The DC-SIGN-related lectin LSECtin mediates antigen capture and pathogen binding by human myeloid cells.''; Blood, 2007 PubMed Europe PMC Scholia
  37. Zhang AP, Bornholdt ZA, Liu T, Abelson DM, Lee DE, Li S, Woods VL Jr, Saphire EO; ''The ebola virus interferon antagonist VP24 directly binds STAT1 and has a novel, pyramidal fold.''; PLoS Pathog, 2012 PubMed Europe PMC Scholia
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History

View all...
CompareRevisionActionTimeUserComment
134288view05:36, 20 July 2024EgonwRemoved a template comment
120623view22:45, 20 December 2021KhanspersModified title
118435view14:40, 27 May 2021Mkutmonfixed publication refs
117706view12:26, 22 May 2021EweitzModified title
101851view14:32, 13 November 2018Elisson nl
101850view14:30, 13 November 2018Elisson nlInteractions correction
98605view20:09, 20 September 2018Elisson nlModified description
98604view19:52, 20 September 2018Elisson nlModified description
98603view19:48, 20 September 2018Elisson nlModification in interactions
98602view19:09, 20 September 2018Elisson nlAnnotated interaction
98332view04:31, 23 August 2018Elisson nlModified description
98331view04:08, 23 August 2018Elisson nlReferences Accentuation Correction
98330view03:54, 23 August 2018Elisson nlReferences Changed
98292view15:35, 16 August 2018DeSlAdded last missing IDs, coloured MHC1 and 2 subunits for clarity 9couldn't find a ID for these groups). Also added a lit. reference describing the effect of LC8 on VP35
98291view15:17, 16 August 2018DeSlAdded more identifiers.
98290view14:57, 16 August 2018DeSlModified description
97372view19:31, 11 May 2018Elisson nlNew References
97362view20:19, 10 May 2018Elisson nlReferences
97361view19:57, 10 May 2018Elisson nlReferences
97360view19:37, 10 May 2018Elisson nlReferences
97357view19:15, 10 May 2018Elisson nlReferences
97356view19:12, 10 May 2018Elisson nlReferences
97353view19:00, 10 May 2018Elisson nlReferences
97351view18:55, 10 May 2018Elisson nlNew References
97327view19:23, 9 May 2018KhanspersOntology Term : 'viral infectious disease' added !
97326view19:22, 9 May 2018KhanspersOntology Term : 'Ebola hemorrhagic fever' added !
97325view19:22, 9 May 2018Khanspersadded xrefs
97170view21:45, 2 May 2018Elisson nlReferences
96845view17:45, 12 April 2018Elisson nlModified description
96805view10:25, 9 April 2018DeSlChanged lines to graphical lines for Ebola virus drawing
96804view10:17, 9 April 2018DeSlAdded IDs from https://www.wikipathways.org/index.php/Pathway:WP4180
96119view02:55, 20 February 2018Elisson nlModified description
96118view02:47, 20 February 2018Elisson nlNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACTBGeneProductENSG00000075624 (Ensembl)
ACTG1GeneProductENSG00000184009 (Ensembl)
ACTINGeneProductIPR004000 (InterPro)
ACTN1GeneProductENSG00000072110 (Ensembl)
ACTN4GeneProductENSG00000130402 (Ensembl)
ADAM17GeneProductENSG00000151694 (Ensembl)
AKT1GeneProductENSG00000142208 (Ensembl)
ASGR1GeneProductENSG00000141505 (Ensembl)
AXLGeneProductENSG00000167601 (Ensembl)
BST2GeneProductENSG00000130303 (Ensembl)
C1QBPGeneProductENSG00000108561 (Ensembl)
CAV1GeneProductENSG00000105974 (Ensembl)
CAV2GeneProductENSG00000105971 (Ensembl)
CAV3GeneProductENSG00000182533 (Ensembl)
CAVEOLINGeneProductIPR001612 (InterPro)
CD209GeneProductENSG00000090659 (Ensembl)
CD300AGeneProductENSG00000167851 (Ensembl)
CDC42GeneProductENSG00000070831 (Ensembl)
CDC44GeneProductP35251 (Uniprot-TrEMBL) Annotated according to synonimic name with RFC1 according to Uniprot (although not mentioned for Homo sapiens species).
CLATHRINGeneProduct1211 (Entrez Gene)
CLEC10AGeneProductENSG00000132514 (Ensembl)
CLEC4GGeneProductENSG00000182566 (Ensembl)
CLEC4MGeneProductENSG00000104938 (Ensembl)
CLEC6AGeneProductENSG00000205846 (Ensembl)
CLTAGeneProductENSG00000122705 (Ensembl)
CLTBGeneProductENSG00000175416 (Ensembl)
CLTCGeneProductENSG00000141367 (Ensembl)
CLTCL1GeneProductENSG00000070371 (Ensembl)
CREBBPGeneProductENSG00000005339 (Ensembl)
CTSBGeneProductENSG00000164733 (Ensembl)
CTSLGeneProductENSG00000135047 (Ensembl)
DAB2IPGeneProductENSG00000136848 (Ensembl)
DDX58GeneProductENSG00000107201 (Ensembl)
EGFRGeneProductENSG00000146648 (Ensembl)
EIF2AK2GeneProductENSG00000055332 (Ensembl)
EIF2S1GeneProductENSG00000134001 (Ensembl)
EP300GeneProductENSG00000100393 (Ensembl)
EPS15GeneProductENSG00000085832 (Ensembl)
ERKGeneProduct
F-ACTINGeneProductENSG00000075624 (Ensembl)
FILAMINGeneProduct
FLNAGeneProductENSG00000196924 (Ensembl)
FLNBGeneProduct
FLNCGeneProductENSG00000128591 (Ensembl)
FOLR1GeneProductENSG00000110195 (Ensembl)
Filamin AGeneProduct2316 (Entrez Gene)
Filamin BGeneProduct2317 (Entrez Gene)
Filamin CGeneProduct2318 (Entrez Gene)
GAS6GeneProductENSG00000183087 (Ensembl)
GELSOLINGeneProductA0A0A0MS51 (Uniprot-TrEMBL)
GSNGeneProductENSG00000148180 (Ensembl)
HAVCR1GeneProductENSG00000113249 (Ensembl)
HAVCR2GeneProductENSG00000135077 (Ensembl)
HLA-AGeneProductENSG00000206503 (Ensembl)
HLA-BGeneProductENSG00000234745 (Ensembl)
HLA-CGeneProductENSG00000204525 (Ensembl)
HLA-DMAGeneProductENSG00000204257 (Ensembl)
HLA-DMBGeneProductENSG00000242574 (Ensembl)
HLA-DOAGeneProductENSG00000204252 (Ensembl)
HLA-DOBGeneProductENSG00000241106 (Ensembl)
HLA-DPA1GeneProductENSG00000231389 (Ensembl)
HLA-DPB1GeneProductENSG00000223865 (Ensembl)
HLA-DQA1GeneProductENSG00000196735 (Ensembl)
HLA-DQA2GeneProductENSG00000237541 (Ensembl)
HLA-DQB1GeneProductENSG00000179344 (Ensembl)
HLA-DQB2GeneProductENSG00000232629 (Ensembl)
HLA-DRAGeneProductENSG00000204287 (Ensembl)
HLA-DRB1GeneProductENSG00000196126 (Ensembl)
HLA-DRB3GeneProduct
HLA-DRB4GeneProduct
HLA-DRB5GeneProductENSG00000198502 (Ensembl)
HLA-EGeneProductENSG00000204592 (Ensembl)
HLA-FGeneProductENSG00000204642 (Ensembl)
HLA-GGeneProductENSG00000204632 (Ensembl)
ICAM2GeneProductENSG00000108622 (Ensembl)
ICAM3GeneProductENSG00000076662 (Ensembl)
IGF1RGeneProductENSG00000140443 (Ensembl)
IKBKEGeneProductENSG00000263528 (Ensembl)
IL4GeneProductENSG00000113520 (Ensembl)
IQGAP1GeneProductENSG00000140575 (Ensembl)
IRF3GeneProductENSG00000126456 (Ensembl)
IRF7GeneProductENSG00000185507 (Ensembl)
ITGA1GeneProductENSG00000213949 (Ensembl)
ITGA2GeneProductENSG00000164171 (Ensembl)
ITGA3GeneProductENSG00000005884 (Ensembl)
ITGA4GeneProductENSG00000115232 (Ensembl)
ITGA5GeneProductENSG00000161638 (Ensembl)
ITGA6GeneProductENSG00000091409 (Ensembl)
ITGAVGeneProductENSG00000138448 (Ensembl)
ITGB1GeneProductENSG00000150093 (Ensembl)
ITGB3GeneProductENSG00000259207 (Ensembl)
KPNA1GeneProductENSG00000114030 (Ensembl)
LC8GeneProduct
MAPK1GeneProductENSG00000100030 (Ensembl)
MAPK3GeneProductMAPK3 (HGNC)
MBL2GeneProductENSG00000165471 (Ensembl)
MERTKGeneProductENSG00000153208 (Ensembl)
MFGE8GeneProductENSG00000140545 (Ensembl)
MHC1GeneProduct
MHC2GeneProduct
NEDD4GeneProductENSG00000069869 (Ensembl)
NFKB1GeneProductENSG00000109320 (Ensembl)
NFKB2GeneProductENSG00000077150 (Ensembl)
NFKBGeneProductENSG00000109320 (Ensembl)
NPC1GeneProductENSG00000141458 (Ensembl)
NPC2GeneProductENSG00000119655 (Ensembl)
PAK1GeneProductENSG00000149269 (Ensembl)
PIK3CAGeneProductENSG00000121879 (Ensembl)
PIK3CBGeneProductENSG00000051382 (Ensembl)
PIK3CDGeneProductENSG00000171608 (Ensembl)
PIK3R1GeneProductENSG00000145675 (Ensembl)
PIK3R2GeneProductENSG00000105647 (Ensembl)
PIK3R3GeneProductENSG00000117461 (Ensembl)
PIK3RGeneProductENSG00000145675 (Ensembl)
PP1GeneProduct
PRKRAGeneProductENSG00000180228 (Ensembl)
RAB5AGeneProductENSG00000144566 (Ensembl)
RAB7AGeneProductENSG00000075785 (Ensembl)
RAB9AGeneProductENSG00000123595 (Ensembl) PUBMED
RAC1GeneProductENSG00000136238 (Ensembl)
RASA2GeneProductENSG00000155903 (Ensembl)
RELGeneProduct
RELAGeneProductENSG00000173039 (Ensembl)
RELBGeneProductENSG00000104856 (Ensembl)
RHOAGeneProductENSG00000067560 (Ensembl)
RHOBGeneProductENSG00000143878 (Ensembl)
RHOCGeneProductENSG00000155366 (Ensembl)
SCINGeneProductENSG00000006747 (Ensembl)
SOCS3GeneProductENSG00000184557 (Ensembl)
STAT1GeneProductENSG00000115415 (Ensembl)
TBK1GeneProductENSG00000183735 (Ensembl)
TFAP2AGeneProductENSG00000137203 (Ensembl)
TIAM1GeneProductENSG00000156299 (Ensembl)
TIMD4GeneProductENSG00000145850 (Ensembl)
TLR4GeneProductENSG00000136869 (Ensembl)
TOP1GeneProductENSG00000198900 (Ensembl)
TPCN2GeneProductENSG00000162341 (Ensembl)
TSG101GeneProductENSG00000074319 (Ensembl)
TYRO3GeneProductENSG00000092445 (Ensembl)
VAV2GeneProductENSG00000160293 (Ensembl)
VPS11GeneProductENSG00000160695 (Ensembl)
VPS16GeneProductENSG00000215305 (Ensembl)
VPS18GeneProductENSG00000104142 (Ensembl)
VPS33AGeneProductENSG00000139719 (Ensembl)
VPS39GeneProductENSG00000166887 (Ensembl)
VPS41GeneProductENSG00000006715 (Ensembl)
VPS4AGeneProductENSG00000132612 (Ensembl)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
ADAM17Exit of Secreted GPArrow13 (Other) PUBMED
ASGR1GP65 (Other) PUBMED
AXLGAS627 (Other) PUBMED
BST2Assembly and BuddingTBar33 (Other) PUBMED
C1QBP46 (Other) PUBMED
CD209GP32 (Other) PUBMED
CD300APtdSer68 (Other) PUBMED
CDC426 (Other) PUBMED
CLATHRIN62 (Other) PUBMED
CLATHRIN63 (Other) PUBMED
CLATHRIN64 (Other) PUBMED
CLEC10AGP31 (Other) PUBMED
CLEC4GGP42 (Other) PUBMED
CLEC6AGP47 (Other) PUBMED
CREBBP57 (Other) PUBMED
CTSBEBOLAArrow2 (Other) PUBMED
CTSLEBOLAArrow3 (Other) PUBMED
EBOLANPC1Arrow4 (Other) PUBMED
EGFRGP11 (Other) PUBMED
EIF2AK2EIF2S1Arrow72 (Other) PUBMED
ERK1 (Other) PUBMED
F-ACTIN7 (Other) PUBMED
FOLR1GP24 (Other) PUBMED
GAS6PtdSer26 (Other) PUBMED
GP1,2ITGA1TBar19 (Other) PUBMED
GP1,2ITGA2TBar23 (Other) PUBMED
GP1,2ITGA3TBar22 (Other) PUBMED
GP1,2ITGA4TBar20 (Other) PUBMED
GP1,2ITGA5TBar21 (Other) PUBMED
GP1,2ITGA6TBar18 (Other) PUBMED
GP1,2ITGB1TBar17 (Other) PUBMED
HAVCR1TIMD437 (Other) PUBMED
HAVCR236 (Other) PUBMED
IGF1RPIK3RArrow67 (Other) PUBMED
IKBKEIRF7Arrow38 (Other) PUBMED
IL4CLEC4GArrow41 (Other) PUBMED
IQGAP1Arrow43 (Other) PUBMED
ITGAV16 (Other) PUBMED
ITGB315 (Other) PUBMED
Interferon Response44 (Other) PUBMED
Interferon Response58 (Other) PUBMED
Interferon ResponseCREBBP59 (Other) PUBMED
Interferon ResponseSTAT154 (Other) PUBMED
KPNA1STAT1TBar40 (Other) PUBMED
MBL2GP45 (Other) PUBMED
MERTKGAS628 (Other) PUBMED
MFGE8PtdSer14 (Other) PUBMED
NEDD4Arrow51 (Other) PUBMED
NPC2NPC1Arrow5 (Other) PUBMED
PAK112 (Other) PUBMED
PAK1CDC428 (Other) PUBMED
PIK3RAKT1Arrow66 (Other) PUBMED
PRKRADDX58Arrow70 (Other) PUBMED
RAB5ALysosomeArrow9 (Other) PUBMED
RAB7ARAB5AArrow10 (Other) PUBMED
RHOB56 (Other) PUBMED
RHOC55 (Other) PUBMED
SOCS3TLR4Arrow52 (Other) PUBMED
TBK1IRF3Arrow39 (Other) PUBMED
TIMD4PtdSer35 (Other) PUBMED
TLR4Cytokine SignalArrow53 (Other) PUBMED
TPCN2Transcription, Traduction and ReplicationArrow48 (Other) PUBMED
TSG101Arrow49 (Other) PUBMED
TYRO3GAS625 (Other) PUBMED
Trans-InfectionICAM2Arrow30 (Other) PUBMED
Trans-InfectionICAM3Arrow29 (Other) PUBMED
Trans-InfectionMHC1Arrow61 (Other) PUBMED
Trans-InfectionMHC2Arrow60 (Other) PUBMED
VP35EIF2AK2TBar71 (Other) PUBMED
VP35PRKRATBar69 (Other) PUBMED
VPS4AArrow50 (Other) PUBMED
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