Modified nucleosides derived from tRNA as urinary cancer markers (Homo sapiens)

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4tRNAN6-methyladenosine2-methylguanosine3-methyluridine7-methylguanosineguanosineN6-threonylcarbomoyladenosineuridine(N)4-acetylcytidineN6-succinyladenosineN2,N2,7-trimethylguanosineinosine111211, 91pseudouridine112-pyridone-5-carboxamide-N1-ribofuranoside1, 5, 81-methylinosineCytidine11-methylguanosine31N2-N2-dimethyl-guanosine1, 6, 7adenosine1-methyl-adenosine1, 278-hydroxy-2'-deoxyguanosine5'-methylthioadenosine1


Description

Modified nucleosides which are primarily derived from tRNA are urinary biomarkers for various types of cancer, such as breast, colon, liver and lung cancer. This pathway provides an overview of these biomarkers, linked to literature and (if know) the mode of modification.

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Cho SH, Choi MH, Lee WY, Chung BC; ''Evaluation of urinary nucleosides in breast cancer patients before and after tumor removal.''; Clin Biochem, 2009 PubMed Europe PMC Scholia
  2. Nakano K, Nakao T, Schram KH, Hammargren WM, McClure TD, Katz M, Petersen E; ''Urinary excretion of modified nucleosides as biological marker of RNA turnover in patients with cancer and AIDS.''; Clin Chim Acta, 1993 PubMed Europe PMC Scholia
  3. Zheng YF, Kong HW, Xiong JH, Lv S, Xu GW; ''Clinical significance and prognostic value of urinary nucleosides in breast cancer patients.''; Clin Biochem, 2005 PubMed Europe PMC Scholia
  4. Jeng LB, Lo WY, Hsu WY, Lin WD, Lin CT, Lai CC, Tsai FJ; ''Analysis of urinary nucleosides as helper tumor markers in hepatocellular carcinoma diagnosis.''; Rapid Commun Mass Spectrom, 2009 PubMed Europe PMC Scholia
  5. Rasmuson T, Björk GR; ''Urinary excretion of pseudouridine and prognosis of patients with malignant lymphoma.''; Acta Oncol, 1995 PubMed Europe PMC Scholia
  6. L.A.Agrofoglio, A.Krstulja., C. De Schutter, P.Favetta, R. Delépéee, V.Roy, C.Dejous, H.Hallil, J.-L.Lachaud, N.Lebal, N.Omar Aouled, V.Raimbault, D.Rebiere, S.Dulong, F.Levi, C.Junot, F.Théodoro, A.Pruvost, R.Vidal; ''Detection of urinary modified nucleosides by a bulk acoustic wave MIP sensor - Results and future work''; https://doi.org/10.1016/j.irbm.2014.02.009, 2014 DOI Scholia
  7. Jeng LB, Lo WY, Hsu WY, Lin WD, Lin CT, Lai CC, Tsai FJ; ''Analysis of urinary nucleosides as helper tumor markers in hepatocellular carcinoma diagnosis.''; Rapid Commun Mass Spectrom, 2009 PubMed Europe PMC Scholia
  8. Frickenschmidt A, Frohlich H, Bullinger D, Zell A, Laufer S, Gleiter CH, Liebich H, Kammerer B; ''Metabonomics in cancer diagnosis: mass spectrometry-based profiling of urinary nucleosides from breast cancer patients.''; Biomarkers, 2008 PubMed Europe PMC Scholia
  9. Nakano K, Nakao T, Schram KH, Hammargren WM, McClure TD, Katz M, Petersen E; ''''; , PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
129319view13:56, 26 March 2024MkutmonOntology Term : 'cancer pathway' added !
129318view13:56, 26 March 2024MkutmonOntology Term : 'disease pathway' added !
128983view03:27, 27 February 2024EweitzFix node type (tRNA is not protein), economize layout, standardize case
119318view13:23, 23 June 2021FinterlyAdded DOI to PublicationXref
117796view14:10, 22 May 2021EweitzModified title
108161view10:44, 29 November 2019FehrhartOntology Term : 'cancer' added !
102340view13:02, 20 December 2018DeSlOntology Term : 'tRNA decay pathway' added !
102339view13:01, 20 December 2018DeSlChanged Ref. layout
102338view12:57, 20 December 2018DeSlAdded wikidata as database source where applicable
102337view12:57, 20 December 2018DeSlAdded id for tRNA.
102336view12:54, 20 December 2018DeSlAnnotated cytidine derivatives.
102335view12:53, 20 December 2018DeSlAnnotated uridine derivatives
102334view12:52, 20 December 2018DeSlAnnotated inosine and derivative
102333view12:49, 20 December 2018DeSlAnnotated adenosine derivatives
102332view12:45, 20 December 2018DeSlAnnotated guanosine derivatives
102331view12:35, 20 December 2018DeSlAdded more lit. refs and biomarkers
102330view12:18, 20 December 2018DeSlModified description
102329view12:15, 20 December 2018DeSlNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
(N)4-acetylcytidineMetaboliteQ20890503 (Wikidata) Breast cancer marker
1-methyl- adenosineMetaboliteQ161643 (Wikidata) Breast cancer marker
1-methylguanosineMetaboliteQ161647 (Wikidata) Breast cancer marker
1-methylinosineMetaboliteQ27109107 (Wikidata) Breast cancer marker
2-methylguanosineMetaboliteQ1419713 (Wikidata) Breast cancer marker
2-pyridone-

5-carboxamide-

N1-ribofuranoside		MetaboliteCouldn't be connected to main nucleoside in tRNA
3-methyluridineMetaboliteQ15632769 (Wikidata) Breast cancer marker
5'-methylthioadenosineMetaboliteQ3599216 (Wikidata) Breast cancer marker
7-methylguanosineMetaboliteQ4642879 (Wikidata) Breast cancer marker
8-hydroxy- 2'-deoxyguanosineMetaboliteQ270154 (Wikidata)
CytidineMetaboliteQ422538 (Wikidata) Hepatocellular carcinoma (HCC) marker
N2,N2,7-trimethylguanosineMetabolite40027-70-1 (CAS) Breast cancer marker
N2-N2-dimethyl- guanosineMetaboliteQ27109160 (Wikidata) Breast cancer marker
N6-methyladenosineMetaboliteQ6951996 (Wikidata) Breast cancer marker
N6-succinyladenosineMetaboliteQ27139416 (Wikidata) Breast cancer marker
N6-threonylcarbomoyladenosineMetabolite
  • Breast cancer marker
  • aka t6A37
adenosineMetaboliteQ190012 (Wikidata)
  • Breast cancer marker
  • Hepatocellular carcinoma (HCC) marker
guanosineMetaboliteQ422462 (Wikidata)
inosineMetaboliteQ422564 (Wikidata) Hepatocellular carcinoma (HCC) marker
pseudouridineMetaboliteQ420445 (Wikidata) Breast cancer marker
tRNAProteinQ201448 (BRENDA)
uridineMetaboliteQ422573 (Wikidata)

Annotated Interactions

No annotated interactions

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