Molybdenum cofactor (Moco) biosynthesis (Homo sapiens)

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Description

Quality Tags

Ontology Terms

Bibliography

1. Nenad Blau, Marinus Duran, K Michael Gibson, Carlo Dionisi-Vici; '''Physician's Guide to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases'''; Springer-Verlag Berlin Heidelberg, 2014
2. Llamas A, Mendel RR, Schwarz G; ''Synthesis of adenylated molybdopterin: an essential step for molybdenum insertion.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
3. Schwarz G; ''Molybdenum cofactor biosynthesis and deficiency.''; Cell Mol Life Sci, 2005 PubMed Europe PMC Scholia
4. Simon Julius Mayr, Juliane Roeper, Guenter Schwarz; ''Alternative splicing of bicistronic MOCS1 defines a novel mitochondrial protein maturation mechanism''; https://doi.org/10.1101/429183, 2018 DOI Scholia

History

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Compare	Revision	Action	Time	User	Comment
	128207	view	02:28, 29 January 2024	Eweitz	Soften disease color, standardize case
	119314	view	13:18, 23 June 2021	Finterly	Added ISBN and DOI Biopax Info
	107173	view	14:26, 17 September 2019	MaintBot	ChEBI identifier normalization
	106144	view	12:04, 16 August 2019	MaintBot	HMDB identifier normalization
	104389	view	13:35, 23 May 2019	Josienlandman	Added Rhea identifiers
	104024	view	17:38, 25 April 2019	IreneHemel	Modified description
	103899	view	11:07, 15 April 2019	Josienlandman	Modified Xanthinuria type I and II
	102862	view	14:50, 25 January 2019	DeSl	Modified title
	102834	view	19:18, 24 January 2019	Egonw	Replaced secondary ChEBI IDs with primary IDs.
	102831	view	16:06, 24 January 2019	DeSl	Added identifier for amidoxine reducing component.
	102828	view	15:48, 24 January 2019	DeSl	Modified description
	102827	view	15:47, 24 January 2019	DeSl	Modified title
	102825	view	15:46, 24 January 2019	DeSl	Ontology Term : 'xanthinuria type II pathway' added !
	102824	view	15:45, 24 January 2019	DeSl	Ontology Term : 'xanthinuria type I pathway' added !
	102823	view	15:45, 24 January 2019	DeSl	Ontology Term : 'xanthinuria' added !
	102822	view	15:45, 24 January 2019	DeSl	Ontology Term : 'molybdenum cofactor deficiency type C' added !
	102821	view	15:45, 24 January 2019	DeSl	Ontology Term : 'molybdenum cofactor deficiency type B' added !
	102820	view	15:44, 24 January 2019	DeSl	Ontology Term : 'molybdenum cofactor deficiency pathway' added !
	102819	view	15:44, 24 January 2019	DeSl	Ontology Term : 'molybdenum cofactor deficiency' added !
	102818	view	15:44, 24 January 2019	DeSl	Ontology Term : 'altered molybdenum cofactor biosynthetic pathway' added !
	102817	view	15:44, 24 January 2019	DeSl	Ontology Term : 'molybdenum cofactor biosynthetic pathway' added !
	102816	view	15:43, 24 January 2019	DeSl	Modified description
	102815	view	15:28, 24 January 2019	DeSl	Annotated Aldehyde oxidase reactions
	102813	view	15:22, 24 January 2019	DeSl	Annotated xanthine oxidase reactions.
	102809	view	15:15, 24 January 2019	DeSl	Annotated Sulfite related reactions
	102808	view	15:11, 24 January 2019	DeSl	Annotated proteins and metabolites on the left.
	102802	view	14:31, 24 January 2019	DeSl	Added lit. ref.
	102801	view	14:30, 24 January 2019	DeSl	Added diseases from Chapter Blau
	102800	view	14:17, 24 January 2019	DeSl	New pathway

External references

DataNodes

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Name	Type	Database reference	Comment
Aldehyde oxidase	Protein
Amidoxime reducing component	Protein
GTP	Metabolite	CHEBI:37565 (ChEBI)
Gephyrin (E domain)	Protein
Gephyrin (G domain)	Protein
MOCS1A	Protein
MOCS1AB	Protein
MOCS2A	Protein
MOCS2B	Protein
MPT	Metabolite
MPT-AMP	Metabolite
Moco	Metabolite	CHEBI:60198 (ChEBI)
R-H	Metabolite
R-NH	Metabolite
R-OH	Metabolite
R=N-OH	Metabolite
Sulfate	Metabolite
Sulfite	Metabolite
Sulfite oxidase	Protein
Uric Acid	Metabolite
Xanthine	Metabolite
Xanthine oxidase	Protein
cPMP	Metabolite	CHEBI:52994 (ChEBI)

Annotated Interactions

No annotated interactions