Integrated breast cancer pathway (Homo sapiens)

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1215792524231315153181621541117222082614525151019G1SCell CycleG2MBASC Complex6, 8, 21NCOA3Cell survival and ProliferationUBP15TRADDMAPKsAnastrozoleSP1CASP9AngiogenesisPLK3CACASP8ABC3GAKT1DihydrotestosteroneUBP16BARD1MSH2Cell SurvivalCERK1ANDRNFKB1fra-1P53SMEK2MRE11RaloxifeneGSK3ACDC42SMAD7NOXA1P13KEstradiolDHTPMLCHK2JKIP1UBIMTAB1MPIP2SMAD1FADDPaclitaxelBAXSMCA4MIR29B1E2F1BMPR1AERKMDM2P38BRCA1ATF1PAK1TGFR1NAB1B5MEC1MYCCASP3GRABL1SMEK1P13BACH1CCND1CASP3Penicillin GCorticosteroneATRIPKAUBP21DNAERRASGRP3RRASMMP1CREBCYP19A1PTENBRCA2AURKABADAKT1CDH1CDK2FADDNCOA2EP300HydroxyureaNocodazoleMitomycinJUNC9JNK1AHRGCRCDK2SIRT1C9JNK1Cell proliferationCDK4TSC2CIP1MIR21CTNB1PPARWEE1ProteasomePLK1TSC1MTORSMAD4RAD50DAG1RPP38PRTAK1LConjugated EstrogensATMIKKABMPR2BRCA1IMPA1KRASODC1B3KP27BADBLMATRApoptosisFlutamideCTNB1 degradationCDC25AANXA1HydrocortisoneIKKASMEK1JAK1SMAD6FulvestrantRAP1ABIDSMAD7EGFRRALACERKJUNTetradecanoylphorbol AcetateCERK1C9JNK1ESR1TFPITamoxifenPKCB1RAC1BCL2PLK3Gene ExpressionLetrozoleSELKP65FOXO1RHOTSC1ITPKCCell Cycle arrestBARD1RRASUBE2FVEGFAIRS1STK11GDIRHEBAQP73P85AHDAC1NF1HDAC1/HDAC2STAT1CSNK1DMYCBAKCBPMAXRASGEF1AP85RAD51HDAC1TGFR2cyc-DTCF/LEFGRNMIR21MIR21ATRFLIP1ExemstaneSMAD3RAFAmpicillinDonepezilCDK7CHK1FluoxymesteroneERAL1TestosteroneRAD54LPIAS1BRAFGADD45AWEE1PHBXRCC3UBP21ProteinMDM2Q8NBS1ARMSH6E2F1MYT1ATMCycloheximideProliferative genesCancer DevelopmentLapatnibRRASApoptosisZMIZ1SMAD2TranscriptionDexamethasoneAnti-ApoptosisMPIP1Methyl MethanesulfonateHIPK2RHOALKB1DCAKDBleomycinSMAD4PlicamycinP53RALGAPA1PPRB/RBLithium Chloride1MIR29B2


Description

This pathway incorporates the most important proteins for Breast Cancer. The Rp score from the Connectivity-Maps (C-Maps) webserver was used to determine the rank of the most important proteins in Breast Cancer. These proteins were then used to determine the most important pathways involved in Breast Cancer by using the Human Pathway Database (HPD). The pathways retrieved from the Human Pathway Database were from several sources such as Protein Lounge, BioCarta, KEGG, and NCI-Nature. The pathways were then annotated. Protein-protein relations for the most important proteins for Breast Cancer were determined by annotating the pathways and by literature review. The protein-protein interactions are mapped onto this pathway.

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Quality Tags

Ontology Terms

 

Bibliography

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  3. Zhang H, Shi X, Zhang QJ, Hampong M, Paddon H, Wahyuningsih D, Pelech S; ''Nocodazole-induced p53-dependent c-Jun N-terminal kinase activation reduces apoptosis in human colon carcinoma HCT116 cells.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
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History

View all...
CompareRevisionActionTimeUserComment
126476view20:57, 5 May 2023EgonwAdded an identifier for the proteasome node
123531view06:33, 2 August 2022EgonwMade two pathways clickable
116548view12:47, 7 May 2021EweitzModified title
116285view21:46, 26 April 2021EweitzModified description
113594view09:46, 4 November 2020DeSlUpdated hydrocortisone ID (to drug ID).
110683view13:17, 28 May 2020EgonwAdded missing @Type annotation
108807view15:48, 30 January 2020DeSlReplaced P65 with MAP3K13
108804view15:38, 30 January 2020DeSlUpdated C9JNK1 to ZN655
108802view15:27, 30 January 2020DeSlRemoved B5MEC1; doesn't exist in original database anymore; no replacement; no lit.ref.
108799view15:00, 30 January 2020DeSlUpdated name FOSL2
108101view10:15, 29 November 2019FehrhartOntology Term : 'cancer pathway' added !
106619view20:46, 12 September 2019KhanspersModified description
106143view12:04, 16 August 2019MaintBotHMDB identifier normalization
105685view07:15, 13 August 2019EgonwReplaced a deprecated UniProt identifiers with the current one.
105682view07:01, 13 August 2019EgonwRemoved a deleted UniProt info, but do not have enough knowledge to replace it, given that the label has the same string.
105628view05:02, 10 August 2019KhanspersModified description
105392view21:37, 6 August 2019EgonwUgh... sorry, I missed that I was adding a secondary ChEBI identifier. Now fixed.
105376view05:01, 6 August 2019EgonwReplaced the PubChem CID with incomplete stereochem with the ChEBI one with full stereochem.
103002view15:01, 31 January 2019Marvin M2Reversed error in miRNA id
102999view14:52, 31 January 2019Marvin M2Updated miRNA ensembl ids
98352view05:24, 24 August 2018EgonwUpdated the MIR21 identifier.
95143view02:51, 17 November 2017AlexanderPicoconnected interactions
93247view12:15, 8 August 2017DeSlConnected unconnected interaction lines with appropriate nodes.
93246view12:06, 8 August 2017DeSlAdded two Pathway nodes, with links to an example PW from WPs.
92369view15:27, 30 May 2017DdiglesReverted to version '09:51, 14 November 2015' by Ddigles
92358view01:59, 30 May 2017Tdavid88Modified description
82941view09:51, 14 November 2015EgonwUpdated Ensembl identifiers.
80445view06:02, 23 June 2015KhanspersAdded mir29b targeting of PTEN
80429view19:56, 22 June 2015KhanspersAdded additional mir21 targeting
80428view19:33, 22 June 2015KhanspersAdded mir21 targeting of BMPR2
80427view19:03, 22 June 2015KhanspersAdded mir21 targeting of PTEN
79991view19:59, 29 April 2015Zariannotated ODC1 , MYC, JUN , fra-1 , cyc-D and PPAR
72732view00:57, 4 December 2013Jakechendeleted unconnected genes.
72731view00:56, 4 December 2013Jakechenupdated DAG1
71652view19:34, 17 October 2013MaintBotUpdated data sources
70228view18:59, 15 July 2013KhanspersReverted to version '11:48, 29 June 2013' by Khanspers
70227view18:57, 15 July 2013Khanspersminor layout
68045view11:48, 29 June 2013EgonwAdded more identifiers for metabolites which were previously marked as 'unknown'.
68044view11:32, 29 June 2013EgonwAdding identifiers for metabolites which were previously marked as 'unknown'.
67397view10:55, 26 June 2013DdiglesOntology Term : 'breast cancer pathway' added !
63220view21:01, 8 May 2013MaintBotUpdating gpml version
59204view19:37, 22 February 2013MaintBotUpdated Ensembl data source
51834view19:03, 23 September 2012SaibrahiPeriodical save, work in progress
51161view21:15, 30 August 2012SaibrahiPeriodical save, work in progress
51083view19:46, 28 August 2012Pragat11Periodical save, work in progress
51082view19:36, 28 August 2012Pragat11Periodical save, work in progress
51081view19:25, 28 August 2012Pragat11Periodical save, work in progress
51020view19:18, 26 August 2012SaibrahiSpecify description
51019view19:12, 26 August 2012SaibrahiPeriodical save, work in progress
51018view19:01, 26 August 2012SaibrahiPeriodical save, work in progress

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABC3GProteinQ9HC16 (Uniprot-TrEMBL)
ABL1GeneProductENSG00000097007 (Ensembl)
AHRGeneProductENSG00000106546 (Ensembl)
AKT1ProteinP31749 (Uniprot-TrEMBL)
ALKB1ProteinQ13686 (Uniprot-TrEMBL)
ANDRProteinP10275 (Uniprot-TrEMBL)
ANXA1GeneProductENSG00000135046 (Ensembl)
AQP73ProteinA6NL99 (Uniprot-TrEMBL)
ARProteinQ9UNE0 (Uniprot-TrEMBL)
ATF1ProteinP18846 (Uniprot-TrEMBL)
ATMProteinQ13315 (Uniprot-TrEMBL)
ATRProteinQ13535 (Uniprot-TrEMBL)
AURKAGeneProductENSG00000087586 (Ensembl)
AmpicillinMetabolite6249 (PubChem-compound)
AnastrozoleMetabolite2102 (Chemspider)
AngiogenesisPathwayWP1993 (WikiPathways) Example of Angiogenesis PW (homo sapiens)
Anti-Apoptosis
Apoptosis
ApoptosisPathwayWP254 (WikiPathways) Example Pw for apoptosis (homo sapiens)
B3KP27ProteinB3KP27 (Uniprot-TrEMBL)
B5MEC1ProteinB5MEC1 (Uniprot-TrEMBL)
BACH1ProteinO14867 (Uniprot-TrEMBL)
BADProteinQ92934 (Uniprot-TrEMBL)
BAKProteinQ16611 (Uniprot-TrEMBL)
BARD1GeneProduct580 (Entrez Gene)
BARD1GeneProductENSG00000138376 (Ensembl)
BAXGeneProductENSG00000087088 (Ensembl)
BCL2ProteinP10415 (Uniprot-TrEMBL)
BIDProteinP55957 (Uniprot-TrEMBL)
BLMProteinP54132 (Uniprot-TrEMBL)
BMPR1AGeneProductENSG00000107779 (Ensembl)
BMPR2ProteinQ13873 (Uniprot-TrEMBL)
BRAFProteinP15056 (Uniprot-TrEMBL)
BRCA1ProteinP38398 (Uniprot-TrEMBL)
BRCA2GeneProductENSG00000139618 (Ensembl)
BleomycinMetabolite456190 (PubChem-compound)
C9JNK1ProteinC9JNK1 (Uniprot-TrEMBL)
CASP3GeneProductENSG00000164305 (Ensembl)
CASP8GeneProductENSG00000064012 (Ensembl)
CASP9GeneProductENSG00000132906 (Ensembl)
CBPGeneProductENSG00000005810 (Ensembl)
CCND1ProteinP24385 (Uniprot-TrEMBL)
CDC25AGeneProduct993 (Entrez Gene)
CDC42GeneProductENSG00000070831 (Ensembl)
CDH1GeneProductENSG00000039068 (Ensembl)
CDK2ProteinP24941 (Uniprot-TrEMBL)
CDK4ProteinP11802 (Uniprot-TrEMBL)
CDK7GeneProduct1022 (Entrez Gene)
CERK1ProteinQ8TCT0 (Uniprot-TrEMBL)
CERKGeneProduct64781 (Entrez Gene)
CHK1ProteinO14757 (Uniprot-TrEMBL)
CHK2ProteinO96017 (Uniprot-TrEMBL) Phosphorylated
CIP1ProteinQ9NPC3 (Uniprot-TrEMBL)
CREBGeneProductENSG00000118260 (Ensembl)
CSNK1DGeneProductENSG00000141551 (Ensembl)
CTNB1 degradation
CTNB1ProteinP35222 (Uniprot-TrEMBL)
CYP19A1GeneProductENSG00000137869 (Ensembl)
Cancer Development
Cell Cycle arrest
Cell Survival
Cell proliferation
Cell survival and Proliferation
Conjugated Estrogens
CorticosteroneMetabolite5753 (PubChem-compound)
CycloheximideMetabolite6197 (PubChem-compound)
DAG1GeneProductENSG00000173402 (Ensembl)
DCAKDProteinQ8WVC6 (Uniprot-TrEMBL)
DHTGeneProductENSG00000181192 (Ensembl)
DNA
DexamethasoneMetabolite5743 (PubChem-compound)
DihydrotestosteroneMetaboliteHMDB02961 (HMDB)
DonepezilMetabolite3152 (PubChem-compound)
E2F1GeneProduct1869 (Entrez Gene)
E2F1ProteinQ01094 (Uniprot-TrEMBL)
EGFRProteinP00533 (Uniprot-TrEMBL)
EP300GeneProductENSG00000100393 (Ensembl)
ERAL1GeneProductENSG00000132591 (Ensembl)
ERKGeneProduct64781 (Entrez Gene)
ERProteinP16591 (Uniprot-TrEMBL)
ESR1GeneProductENSG00000091831 (Ensembl)
EstradiolMetabolite5757 (PubChem-compound)
Exemstane
FADDGeneProductENSG00000168040 (Ensembl)
FADDProteinQ13158 (Uniprot-TrEMBL)
FLIP1ProteinQ7Z7B0 (Uniprot-TrEMBL)
FOXO1GeneProductENSG00000150907 (Ensembl)
FluoxymesteroneMetabolite6205 (Chemspider)
FlutamideMetabolite3397 (PubChem-compound)
FulvestrantMetabolite104741 (PubChem-compound)
GADD45AGeneProductENSG00000116717 (Ensembl)
GCRGeneProductENSG00000113161 (Ensembl)
GDIGeneProduct2664 (Entrez Gene)
GR ProteinP01833 (Uniprot-TrEMBL)
GRNGeneProductENSG00000030582 (Ensembl)
GSK3AProteinP49840 (Uniprot-TrEMBL)
Gene Expression
HDAC1Protein
HDAC1/HDAC2GeneProductENSG00000116478 (Ensembl)
HDAC1ProteinQ13547 (Uniprot-TrEMBL)
HIPK2ProteinQ9H2X6 (Uniprot-TrEMBL)
HydrocortisoneMetabolite5754 (PubChem-compound)
HydroxyureaMetabolite3657 (PubChem-compound)
IKKAProteinO15111 (Uniprot-TrEMBL)
IMPA1GeneProductENSG00000133731 (Ensembl)
IPKAProteinP61925 (Uniprot-TrEMBL)
IRS1GeneProductENSG00000169047 (Ensembl)
ITPKCGeneProductENSG00000086544 (Ensembl)
JAK1ProteinP23458 (Uniprot-TrEMBL)
JKIP1ProteinQ96N16 (Uniprot-TrEMBL)
JUNProtein3725 (Entrez Gene)
JUNGeneProductENSG00000177606 (Ensembl)
KRASGeneProductENSG00000133703 (Ensembl)
LapatnibMetabolite208908 (PubChem-compound)
LetrozoleMetabolite3765 (Chemspider)
Lithium ChlorideMetabolite433294 (PubChem-compound)
MAPKsGeneProduct5594 (Entrez Gene)
MAXProteinP61244 (Uniprot-TrEMBL)
MDM2ProteinQ00987 (Uniprot-TrEMBL)
MIR21RnaENSG00000284190 (Ensembl)
MIR29B1RnaENSG00000283797 (Ensembl)
MIR29B2RnaENSG00000284204 (Ensembl)
MMP1ProteinP03956 (Uniprot-TrEMBL)
MPIP1ProteinP30304 (Uniprot-TrEMBL)
MPIP2 ProteinP30305 (Uniprot-TrEMBL)
MRE11ProteinP49959 (Uniprot-TrEMBL)
MSH2ProteinP43246 (Uniprot-TrEMBL)
MSH6ProteinP52701 (Uniprot-TrEMBL)
MTORGeneProductENSG00000198793 (Ensembl)
MYCProtein4609 (Entrez Gene)
MYCProteinP01106 (Uniprot-TrEMBL)
MYT1ProteinQ01538 (Uniprot-TrEMBL)
Methyl MethanesulfonateMetabolite4156 (PubChem-compound)
MitomycinMetaboliteCHEBI:25357 (ChEBI)
NAB1ProteinQ13506 (Uniprot-TrEMBL)
NCOA2GeneProductENSG00000124151 (Ensembl)
NCOA3GeneProductENSG00000124151 (Ensembl)
NF1ProteinP21359 (Uniprot-TrEMBL)
NFKB1 ProteinP19838 (Uniprot-TrEMBL)
NOXA1ProteinQ86UR1 (Uniprot-TrEMBL)
NocodazoleMetabolite4122 (PubChem-compound)
ODC1Protein4953 (Entrez Gene)
P13KGeneProductENSG00000229882 (Ensembl)
P13ProteinQ9UHV8 (Uniprot-TrEMBL)
P38GeneProduct84640 (Entrez Gene)
P53ProteinP04637 (Uniprot-TrEMBL)
P65 ProteinC9JP65 (Uniprot-TrEMBL)
P85AGeneProductENSG00000125450 (Ensembl)
P85ProteinO00459 (Uniprot-TrEMBL)
PAK1ProteinQ13153 (Uniprot-TrEMBL)
PHBGeneProductENSG00000167085 (Ensembl)
PIAS1ProteinO75925 (Uniprot-TrEMBL)
PKCB1ProteinQ9ULU4 (Uniprot-TrEMBL)
PLK1ProteinP53350 (Uniprot-TrEMBL)
PLK3CAGeneProduct1263 (Entrez Gene)
PLK3GeneProductENSG00000173846 (Ensembl)
PMLProteinP29590 (Uniprot-TrEMBL)
PPARProtein8061 (Entrez Gene)
PPRB/RBProteinP06400 (Uniprot-TrEMBL)
PRProteinP12270 (Uniprot-TrEMBL)
PTENProteinP60484 (Uniprot-TrEMBL)
PaclitaxelMetabolite10368587 (Chemspider)
Penicillin GMetabolite5693 (Chemspider)
PlicamycinMetabolite457831 (PubChem-compound)
Proliferative genes
Proteasome
ProteinProtein
Q8NBS1ProteinQ8NBS1 (Uniprot-TrEMBL)
RAC1ProteinP63000 (Uniprot-TrEMBL)
RAD50ProteinQ92878 (Uniprot-TrEMBL)
RAD51ProteinQ06609 (Uniprot-TrEMBL)
RAD54LGeneProductENSG00000085999 (Ensembl)
RAFProteinP10398 (Uniprot-TrEMBL)
RALAProteinP11233 (Uniprot-TrEMBL)
RALGAPA1GeneProductENSG00000174373 (Ensembl)
RAP1AGeneProductENSG00000116473 (Ensembl)
RASGEF1AGeneProduct221002 (Entrez Gene)
RASGRP3GeneProductENSG00000152689 (Ensembl)
RHEBProteinQ15382 (Uniprot-TrEMBL)
RHOGeneProduct6010 (Entrez Gene)
RHOGeneProductENSG00000163914 (Ensembl)
RPP38GeneProductENSG00000152464 (Ensembl)
RRASProteinP10301 (Uniprot-TrEMBL)
RaloxifeneMetabolite4859 (Chemspider)
SELKProteinQ9Y6D0 (Uniprot-TrEMBL)
SIRT1ProteinQ96EB6 (Uniprot-TrEMBL)
SMAD1ProteinQ15797 (Uniprot-TrEMBL)
SMAD2ProteinQ15796 (Uniprot-TrEMBL)
SMAD3ProteinQ13485 (Uniprot-TrEMBL)
SMAD4ProteinQ13485 (Uniprot-TrEMBL)
SMAD4ProteinQ15796 (Uniprot-TrEMBL)
SMAD6ProteinO43541 (Uniprot-TrEMBL)
SMAD7ProteinO15105 (Uniprot-TrEMBL)
SMCA4ProteinP51532 (Uniprot-TrEMBL)
SMEK1GeneProductENSG00000100796 (Ensembl)
SMEK2GeneProductENSG00000275052 (Ensembl)
SP1GeneProductENSG00000185591 (Ensembl)
STAT1ProteinP42224 (Uniprot-TrEMBL)
STK11GeneProductENSG00000118046 (Ensembl)
TAB1ProteinQ15750 (Uniprot-TrEMBL)
TAK1LProteinP57077 (Uniprot-TrEMBL)
TCF/LEFProtein
TFPIGeneProductENSG00000003436 (Ensembl)
TGFR1ProteinP36897 (Uniprot-TrEMBL)
TGFR2ProteinP37173 (Uniprot-TrEMBL)
TRADDProteinQ15628 (Uniprot-TrEMBL)
TSC1GeneProductENSG00000165699 (Ensembl)
TSC1ProteinQ92574 (Uniprot-TrEMBL)
TSC2GeneProductENSG00000103197 (Ensembl)
TamoxifenMetabolite2733526 (PubChem-compound)
TestosteroneMetabolite5791 (Chemspider)
Tetradecanoylphorbol AcetateMetabolite22833501 (PubChem-compound)
Transcription
UBE2FProteinQ969M7 (Uniprot-TrEMBL)
UBIMProteinP35544 (Uniprot-TrEMBL)
UBP15ProteinQ9Y4E8 (Uniprot-TrEMBL)
UBP16ProteinQ9Y5T5 (Uniprot-TrEMBL)
UBP21ProteinQ9UK80 (Uniprot-TrEMBL)
VEGFAGeneProductENSG00000112715 (Ensembl)
WEE1ProteinP30291 (Uniprot-TrEMBL)
XRCC3GeneProductENSG00000126215 (Ensembl)
ZMIZ1ProteinQ9ULJ6 (Uniprot-TrEMBL)
cyc-DProtein
fra-1Protein8061 (Entrez Gene)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1984"
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