Portal:ExRNA/FeaturedPathways

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T-Cell Receptor and Co-stimulatory Signaling

Takahashi et al. Long non-coding RNA in liver diseases

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IL1 and megakaryotyces in obesity

Beaulieu et al. Interleukin 1 receptor 1 and interleukin 1beta regulate megakaryocyte maturation, platelet activation, and transcript profile during inflammation in mice and humans

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miRNA mechanism of action and biogenesis

Ozpolat et al. Liposomal siRNA nanocarriers for cancer therapy Thomas et al. Eri1: a conserved enzyme at the crossroads of multiple RNA-processing pathways

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Extracellular vesicle-mediated signaling in recipient cells

Gangoda et al. Extracellular vesicles including exosomes are mediators of signal transduction: Are they protective or pathogenic?

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TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer

Yang et al. Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer

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mir34a and TGIF2 in osteoclastogenesis

Krzeszinski et al. miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2

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mir219 in Oligodendrocyte Differentiation and Myelination

Pusic et al. Youth and environmental enrichment generate serum exosomes containing miR-219 that promote CNS myelination

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Apoptosis-related network due to altered Notch3 in ovarian cancer

Hu et al. Notch3 pathway alterations in ovarian cancer

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miR-222 in Exercise-Induced Cardiac Growth

Liu et al. miR-222 Is Necessary for Exercise-Induced Cardiac Growth and Protects against Pathological Cardiac Remodeling

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Hypoxia-mediated EMT and Stemness

van den Beucken et al. Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER

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DDX1 as a regulatory component of the Drosha microprocessor

Han et al. The RNA-binding protein DDX1 promotes primary microRNA maturation and inhibits ovarian tumor progression

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EV release from cardiac cells and their functional effects

Danielson and Das, Extracellular Vesicles in Heart Disease: Excitement for the Future?

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Rac1/Pak1/p38/MMP-2 pathway

Gonzalez-Villasana et al. Rac1/Pak1/p38/MMP-2 Axis Regulates Angiogenesis in Ovarian Cancer

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eIF5A regulation in response to inhibition of the nuclear export system

Miyake et al. XPO1/CRM1 Inhibition Causes Antitumor Effects by Mitochondrial Accumulation of eIF5A

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MFAP5-mediated ovarian cancer cell motility and invasiveness

Leung et al. Calcium-dependent FAK/CREB/TNNC1 signalling mediates the effect of stromal MFAP5 on ovarian cancer metastatic potential

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LncRNA-mediated mechanisms of therapeutic resistance

Parasramka et al. Long non-coding RNAs as novel targets for therapy in hepatocellular carcinoma

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ApoE and miR-146 in inflammation and atherosclerosis

Li et al. Apolipoprotein E enhances microRNA-146a in monocytes and macrophages to suppress nuclear factor-κB-driven inflammation and atherosclerosis

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miR-148a/miR-31/FIH1/HIF1α-Notch signaling in glioblastoma

Wong et al. The Cancer Genome Atlas Analysis Predicts MicroRNA for Targeting Cancer Growth and Vascularization in Glioblastoma

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mir-124 predicted interactions with cell cycle and differentiation

Shields et al. A genome-scale screen reveals context-dependent ovarian cancer sensitivity to miRNA overexpression

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miR-517 relationship with ARCN1 and USP1

Shields et al. A genome-scale screen reveals context-dependent ovarian cancer sensitivity to miRNA overexpression

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miR-509-3p alteration of YAP1/ECM axis

Pan et al. miR-509-3p is clinically significant and strongly attenuates cellular migration and multi-cellular spheroids in ovarian cancer

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H19 action Rb-E2F1 signaling and CDK-β-catenin activity

Ohtsuka et al. H19 Noncoding RNA, an Independent Prognostic Factor, Regulates Essential Rb-E2F and CDK8-β-Catenin Signaling in Colorectal Cancer

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mir-193a and MVP in colon cancer metastasis

Teng et al. H19 MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression

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miRNA regulation of p53 pathway in prostate cancer

Moustafa et al. Identification of microRNA signature and potential pathway targets in prostate cancer

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miRNA regulation of prostate cancer signaling pathways

Moustafa et al. Identification of microRNA signature and potential pathway targets in prostate cancer

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LncRNA involvement in canonical Wnt signaling and colorectal cancer

Shen et al. To Wnt or Lose: The Missing Non-Coding Linc in Colorectal Cancer

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Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer

Vannini et al. Transcribed ultraconserved region 339 promotes carcinogenesis by modulating tumor suppressor microRNAs

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Extracellular vesicles in the crosstalk of cardiac cells

Bei et al. Extracellular Vesicles in Cardiovascular Theranostics.

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Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells

Datta et al. Manumycin A suppresses exosome biogenesis and secretion via targeted inhibition of Ras/Raf/ERK1/2 signaling and hnRNP H1 in castration-resistant prostate cancer cells

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miRNAs in the signaling pathway of the immune response in sepsis

Giza et al. Cellular and viral microRNAs in sepsis: mechanisms of action and clinical applications

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ncRNAs involved in Wnt signaling in hepatocellular carcinoma

Klingenberg et al. Non-coding RNA in hepatocellular carcinoma: Mechanisms, biomarkers and therapeutic targets

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ncRNAs involved in STAT3 signaling in hepatocellular carcinoma

Klingenberg et al. Non-coding RNA in hepatocellular carcinoma: Mechanisms, biomarkers and therapeutic targets

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PDGFRα and STMN1 cooperate to exacerbate the cytotoxic effects of vinblastine

Jun et al. A PDGFRα-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine

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Model for regulation of MSMP expression in cancer cells and its proangiogenic role in ovarian tumors

Mitamara et al. Induction of anti-VEGF therapy resistance by upregulated expression of microseminoprotein (MSMP)

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MicroRNA network associated with Chronic lymphocytic leukemia

Ciccone and Calin, MicroRNAs in Chronic Lymphocytic Leukemia: An Old Disease with New Genetic Insights

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FABP4 in ovarian cancer

Gharpure et al, FABP4 as a key determinant of metastatic potential of ovarian cancer

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Platelet-mediated interactions with vascular and circulating cells

Koupenova et al, Circulating Platelets as Mediators of Immunity, Inflammation, and Thrombosis

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Circulating monocytes and cardiac macrophages in diastolic dysfunction

Hulsmans et al, Cardiac macrophages promote diastolic dysfunction

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Translational regulation by PDGFRα

Zhou et al, Chronic platelet-derived growth factor receptor signaling exerts control over initiation of protein translation in glioma

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MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement

Leung et al, Cancer-associated fibroblasts regulate endothelial adhesion protein LPP to promote ovarian cancer chemoresistance

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Interactions between immune cells and microRNAs in tumor microenvironment

Cortez et al, Role of miRNAs in immune responses and immunotherapy in cancer

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Alzheimers Disease
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Parkinsons Disease
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Mir302-367 Promoting Cardiomyocyte Proliferation
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MicroRNAs in cardiomyocyte hypertrophy
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Integrated Lung Cancer Pathway
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miRNA Biogenesis
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miRNA targets in ECM and membrane receptors
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Fluoropyrimidine Activity
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miRNAs involved in DNA damage response
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Metastatic Brain Tumor
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Regulatory RNA pathways
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Spinal Cord Injury
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miRNA Regulation of DNA Damage Response
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Parkinsons Disease Pathway (Mus musculus)
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Hepatitis C and Hepatocellular Carcinoma
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Metastatic brain tumor
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Role of Osx and miRNAs in tooth development
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miR-127 in mesendoderm differentiation
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Mecp2 and Associated Rett Syndrome
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miRs in Muscle Cell Differentiation
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Cell Differentiation
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Signaling Pathways in Glioblastoma
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REBF and miR33 in cholesterol and lipid homeostasis
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miR-targeted genes in lymphocytes - TarBase

TarBase

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miR-targeted genes in muscle cell - TarBase

TarBase

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miR-targeted genes in leukocytes - TarBase

TarBase

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miR-targeted genes in squamous cell - TarBase

TarBase

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miR-targeted genes in epithelium - TarBase

TarBase

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TarBasePathway

TarBase

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miR-targeted genes in adipocytes - TarBase

TarBase

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Ectoderm Differentiation
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Endoderm Differentiation
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Mesodermal Commitment Pathway
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SRF and miRs in Smooth Muscle Differentiation and Proliferation
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ErbB Signaling Pathway
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