Leptin-insulin signaling overlap (Homo sapiens)

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11IRSIRSIRSPI3KDNAINSRLEPPIP3JAK2SOCS1PIP2DGKZSTAT3STAT3PIK3CGAKT1STAT3IRS1SOCS3JAK2PIK3CGLEPRJAK2PDPK1SOCS2Irs3INSIRS2PIK3R3IRS4


Description

Overlap of cellular insulin and leptin signaling. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

Comments

HomologyMapper 
This pathway was inferred from Mus musculus pathway "Leptin Insulin Overlap", WP578 revision, with a 95.0% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Banks AS, Davis SM, Bates SH, Myers MG Jr; ''Activation of downstream signals by the long form of the leptin receptor.''; J Biol Chem, 2000 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
118425view14:24, 27 May 2021Mkutmonremoved unused reference
116797view10:02, 14 May 2021EweitzModified title
107152view14:23, 17 September 2019MaintBotChEBI identifier normalization
106627view20:53, 12 September 2019KhanspersModified description
105633view05:04, 10 August 2019KhanspersModified description
90771view01:19, 14 December 2016KhanspersOntology Term : 'leptin system pathway' added !
90770view01:18, 14 December 2016KhanspersOntology Term : 'insulin signaling pathway' added !
90769view01:18, 14 December 2016KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProductENSG00000142208 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11651
DGKZGeneProductENSG00000149091 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000040479
INSGeneProductENSG00000254647 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16333
INSRGeneProductENSG00000171105 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16337
IRS1GeneProductENSG00000169047 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16367
IRS2GeneProductENSG00000185950 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:384783
IRS4GeneProductENSG00000133124 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16370
Irs3GeneProductNo homologues found for original id L:16369
JAK2GeneProductENSG00000096968 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16452
LEPGeneProductENSG00000174697 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P41160
LEPRGeneProductENSG00000116678 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16847
PDPK1GeneProductENSG00000140992 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18607
PIK3CGGeneProductENSG00000105851 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000020573
PIK3R3GeneProductENSG00000117461 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000028698
PIP2MetaboliteCHEBI:18348 (ChEBI)
PIP3Metabolite16618 (ChEBI)
SOCS1GeneProductENSG00000185338 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12703
SOCS2GeneProductENSG00000120833 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:216233
SOCS3GeneProductENSG00000184557 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12702
STAT3GeneProductENSG00000168610 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20848

Annotated Interactions

No annotated interactions
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