Senescence and autophagy in cancer (Homo sapiens)

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5332, 41, 435AUTOPHAGOSOMECDK4PI3K?ATG16CDK2SLC39A4CDC25BISREHMGA1IFI16MAP2K6TNFSF15COL10A1RNASELGSNIL6IL6STRSL1D1CREG1TGFB1CXCL20GeneProductRB1CC1BMI1MAPK14CDKN2ACD44GABARAPL2HRASATG14MAP1LC3BFN1IL24MMP14CDKN2ACXCL14SERPINE1bcl-xLATG16L1SMAD4MIR29B1IRF5IFNGRB1GASIRF1GBLGeneProductCCL3CDK2ATG4ATG7CDKN1AIL6RMIR29CATG12IRF7AKT1S1?SMAD3IL8SLC39A1IGF1MAP1LC3AMIR29B2IL1BC/EBP-betaMAP2K1INSNFKBSLC39A3COL1A1MAP2K3LAMP2IL3SQSTM1MIR29B1INHBAUVRAGGABARAPL1PTENE2F1ING1RAF1ATG10SPARCPLATCDKN1ACOL3A1GAD45AGABARAPMAP1LC3CBECN1SLC39A2ATG17ATG3FRAP1TP53GSK3BPLAUCDKN2AJUNMMP-3PIK3C3PIP3(16:0/16:0)IGFBP7SERPINB2IGFBP3MDM2PIK3C3CDK6IGFBP5MIR29CBRAFATG7CDKN1ASH3GLB1IGF1RSRCVTNIFNB1FKBP8ATG11MIR29B2ING2KIAA0652IL1ATHBS1ATG6BCL2CXCR2CDKN2ABMP2pkb?MLLCDKN1BAMBRA1ATG5LAMP1MAPK1ULK1CXCL1PCNAMIR29C


Description

Senescense and Autophagy Pathways in Cancer. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Ontology Terms

 

Bibliography

  1. Wang C, Bian Z, Wei D, Zhang JG; ''miR-29b regulates migration of human breast cancer cells.''; Mol Cell Biochem, 2011 PubMed Europe PMC Scholia
  2. Garzon R, Heaphy CE, Havelange V, Fabbri M, Volinia S, Tsao T, Zanesi N, Kornblau SM, Marcucci G, Calin GA, Andreeff M, Croce CM; ''MicroRNA 29b functions in acute myeloid leukemia.''; Blood, 2009 PubMed Europe PMC Scholia
  3. Sengupta S, den Boon JA, Chen IH, Newton MA, Stanhope SA, Cheng YJ, Chen CJ, Hildesheim A, Sugden B, Ahlquist P; ''MicroRNA 29c is down-regulated in nasopharyngeal carcinomas, up-regulating mRNAs encoding extracellular matrix proteins.''; Proc Natl Acad Sci U S A, 2008 PubMed Europe PMC Scholia
  4. Zhao JJ, Lin J, Lwin T, Yang H, Guo J, Kong W, Dessureault S, Moscinski LC, Rezania D, Dalton WS, Sotomayor E, Tao J, Cheng JQ; ''microRNA expression profile and identification of miR-29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma.''; Blood, 2010 PubMed Europe PMC Scholia
  5. Kuilman T, Michaloglou C, Vredeveld LC, Douma S, van Doorn R, Desmet CJ, Aarden LA, Mooi WJ, Peeper DS; ''Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network.''; Cell, 2008 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
116733view10:59, 11 May 2021EweitzModified title
115575view09:09, 27 February 2021EgonwAdded missing DataNode types
108116view10:23, 29 November 2019FehrhartOntology Term : 'cancer pathway' added !
106820view13:30, 17 September 2019MaintBotHMDB identifier normalization
106488view21:41, 4 September 2019KhanspersModified description
105458view05:08, 8 August 2019KhanspersModified description
98554view18:21, 16 September 2018AlexanderPicoupdated outdated ensembl
97621view07:36, 31 May 2018AMTanOntology Term : 'cancer' added !
81193view13:56, 3 August 2015Mkutmonfix unconnected lines
80451view20:25, 23 June 2015KhanspersModified title
80448view06:19, 23 June 2015KhanspersAdded mir29c
80446view06:12, 23 June 2015KhanspersAdded mir29c
80444view05:57, 23 June 2015KhanspersAdded mir29b targeting of PTEN
80442view05:45, 23 June 2015KhanspersAdded mir29b targeting of CDK6
80195view23:00, 19 May 2015Khanspersupdated mir29c target interactions
80159view20:59, 14 May 2015KhanspersAdded two more mir29c targets
80156view20:36, 14 May 2015Khanspersconnected interactions
80155view20:34, 14 May 2015KhanspersAdded mir29c targeting of SPARC
71375view18:38, 17 October 2013MaintBotAutomated update of data sources
60842view11:52, 29 March 2013EgonwFixed a metabolite which was annotated as GeneProduct.
59170view18:34, 22 February 2013MaintBotUpdated Ensembl and UniProt data source
47912view19:26, 18 April 2012Khanspersupdated xrefs
47911view19:23, 18 April 2012Khanspersupdated xrefs
45024view18:43, 6 October 2011ThomasOntology Term : 'autophagy pathway' added !
45023view18:43, 6 October 2011ThomasOntology Term : 'senescence pathway' added !
41102view23:22, 1 March 2011MaintBotRemoved redundant pathway information and comments
34820view16:22, 21 January 2010Sham.ukPeriodical save, work in progress
34819view14:00, 21 January 2010Sham.ukPeriodical save, work in progress
34818view13:50, 21 January 2010Sham.ukPeriodical save, work in progress
34817view13:39, 21 January 2010Sham.ukPeriodical save, work in progress
34816view13:29, 21 January 2010Sham.ukPeriodical save, work in progress
34815view12:03, 21 January 2010Sham.ukPeriodical save, work in progress
34468view18:31, 10 December 2009MaintBotAutomatic update of empty xrefs
32660view22:19, 25 August 2009KhanspersModified categories
32166view14:06, 14 August 2009MaintBotFixed group labels
29697view13:00, 28 May 2009Sham.ukPeriodical save, work in progress
29696view12:38, 28 May 2009Sham.ukPeriodical save, work in progress
29531view10:07, 12 May 2009Sham.ukPeriodical save, work in progress
28686view13:15, 24 February 2009Sham.ukPeriodical save, work in progress
28685view13:05, 24 February 2009Sham.ukPeriodical save, work in progress
28684view12:55, 24 February 2009Sham.ukPeriodical save, work in progress
28108view10:10, 26 January 2009Sham.ukPeriodical save, work in progress
28107view09:59, 26 January 2009Sham.ukPeriodical save, work in progress
28000view16:17, 22 January 2009Sham.ukPeriodical save, work in progress
27998view16:12, 22 January 2009Sham.ukSpecify description
27996view13:12, 22 January 2009Sham.ukPeriodical save, work in progress
27994view12:21, 22 January 2009Sham.ukPeriodical save, work in progress
27992view12:11, 22 January 2009Sham.ukPeriodical save, work in progress
27990view12:01, 22 January 2009Sham.ukPeriodical save, work in progress
27988view11:51, 22 January 2009Sham.ukPeriodical save, work in progress

External references

DataNodes

View all...
NameTypeDatabase referenceComment
?GeneProduct
AKT1S1GeneProductENSG00000204673 (Ensembl)
AMBRA1GeneProduct55626 (Entrez Gene)
ATG10GeneProduct83734 (Entrez Gene)
ATG11GeneProduct
ATG12GeneProduct9140 (Entrez Gene)
ATG14GeneProduct22863 (Entrez Gene)
ATG16GeneProduct9474 (Entrez Gene)
ATG16L1GeneProductENSG00000085978 (Ensembl)
ATG17GeneProduct
ATG3GeneProduct64422 (Entrez Gene)
ATG4GeneProduct
ATG5GeneProduct9474 (Entrez Gene)
ATG6GeneProduct
ATG7GeneProduct10533 (Entrez Gene)
BCL2GeneProduct596 (Entrez Gene)
BECN1GeneProduct8678 (Entrez Gene)
BMI1GeneProduct648 (Entrez Gene) ARF
BMP2GeneProduct650 (Entrez Gene) tPA
BRAFGeneProduct673 (Entrez Gene)
C/EBP-betaGeneProduct1051 (Entrez Gene)
CCL3GeneProduct6348 (Entrez Gene)
CD44GeneProduct960 (Entrez Gene)
CDC25BGeneProduct994 (Entrez Gene)
CDK2GeneProduct1029 (Entrez Gene) ARF
CDK4GeneProduct1029 (Entrez Gene) ARF
CDK6GeneProduct1029 (Entrez Gene) ARF
CDKN1AGeneProduct1026 (Entrez Gene) P21/CIP1/WAF1
CDKN1BGeneProduct1027 (Entrez Gene) P27/KIP
CDKN2AGeneProduct1029 (Entrez Gene)
COL10A1GeneProduct1300 (Entrez Gene) MKK3
COL1A1GeneProduct1277 (Entrez Gene)
COL3A1GeneProduct1281 (Entrez Gene)
CREG1GeneProduct8804 (Entrez Gene)
CXCL1GeneProduct2919 (Entrez Gene) GROa
CXCL14GeneProduct9547 (Entrez Gene) BRAK
CXCL20GeneProduct
CXCR2GeneProduct1026 (Entrez Gene)
E2F1GeneProduct1869 (Entrez Gene)
FKBP8GeneProductENSG00000105701 (Ensembl)
FN1GeneProduct2335 (Entrez Gene)
FRAP1GeneProduct2475 (Entrez Gene) mTOR
GABARAPGeneProduct11337 (Entrez Gene)
GABARAPL1GeneProduct23710 (Entrez Gene)
GABARAPL2GeneProduct11345 (Entrez Gene)
GAD45AGeneProduct
GASTFBSDNA regulatory element
GBLGeneProductENSG00000167965 (Ensembl)
GSK3BGeneProduct2932 (Entrez Gene)
GSNGeneProduct2934 (Entrez Gene)
GeneProductGeneProduct
HMGA1GeneProduct3159 (Entrez Gene)
HRASGeneProduct3265 (Entrez Gene) H-RAS
IFI16GeneProduct3428 (Entrez Gene)
IFNB1GeneProduct3456 (Entrez Gene)
IFNGGeneProduct3458 (Entrez Gene)
IGF1GeneProduct3479 (Entrez Gene)
IGF1RGeneProduct3480 (Entrez Gene)
IGFBP3GeneProduct3486 (Entrez Gene)
IGFBP5GeneProduct3488 (Entrez Gene)
IGFBP7GeneProduct3490 (Entrez Gene) ARF
IL1AGeneProduct3552 (Entrez Gene)
IL1BGeneProduct3553 (Entrez Gene)
IL24GeneProduct11009 (Entrez Gene)
IL3GeneProduct3562 (Entrez Gene)
IL6GeneProduct3569 (Entrez Gene)
IL6RGeneProduct3570 (Entrez Gene)
IL6STGeneProduct3572 (Entrez Gene)
IL8GeneProduct3576 (Entrez Gene)
ING1GeneProduct3621 (Entrez Gene)
ING2GeneProduct3622 (Entrez Gene)
INHBAGeneProduct3624 (Entrez Gene)
INSGeneProduct3630 (Entrez Gene) BRAK
IRF1GeneProduct3659 (Entrez Gene)
IRF5GeneProduct3663 (Entrez Gene)
IRF7GeneProduct3665 (Entrez Gene)
ISRETFBSDNA regulatory element
JUNGeneProduct3725 (Entrez Gene) P21/CIP1/WAF1
KIAA0652GeneProductENSG00000175224 (Ensembl)
LAMP1GeneProduct3916 (Entrez Gene)
LAMP2GeneProduct3920 (Entrez Gene)
MAP1LC3AGeneProduct84557 (Entrez Gene)
MAP1LC3BGeneProduct81631 (Entrez Gene)
MAP1LC3CGeneProduct440738 (Entrez Gene)
MAP2K1GeneProduct5604 (Entrez Gene) MEK
MAP2K3GeneProduct5606 (Entrez Gene) MKK3
MAP2K6GeneProduct5606 (Entrez Gene) MEK6
MAPK14GeneProduct1432 (Entrez Gene) P38a
MAPK1GeneProduct5594 (Entrez Gene) ERK
MDM2GeneProduct4193 (Entrez Gene)
MIR29B1RnaENSG00000265410 (Ensembl)
MIR29B2RnaENSG00000207790 (Ensembl)
MIR29CRnaENSG00000203709 (Ensembl)
MLLGeneProduct4297 (Entrez Gene) ARF
MMP-3GeneProduct
MMP14GeneProduct4323 (Entrez Gene)
NFKBGeneProduct1026 (Entrez Gene) P21/CIP1/WAF1
PCNAGeneProduct5111 (Entrez Gene)
PI3K?GeneProduct
PIK3C3GeneProduct5289 (Entrez Gene) VPS34
PIK3C3GeneProductENSG00000078142 (Ensembl)
PIP3(16:0/16:0)MetaboliteHMDB0010147 (HMDB)
PLATGeneProduct5327 (Entrez Gene) tPA
PLAUGeneProduct5328 (Entrez Gene) uPA
PTENGeneProduct5728 (Entrez Gene)
RAF1GeneProduct5894 (Entrez Gene)
RB1GeneProduct5925 (Entrez Gene)
RB1CC1GeneProductENSG00000023287 (Ensembl)
RNASELGeneProduct6041 (Entrez Gene)
RSL1D1GeneProduct26156 (Entrez Gene)
SERPINB2GeneProduct5055 (Entrez Gene)
SERPINE1GeneProduct5054 (Entrez Gene) PAI1
SH3GLB1GeneProduct51100 (Entrez Gene) BIF1
SLC39A1GeneProduct27173 (Entrez Gene)
SLC39A2GeneProduct29986 (Entrez Gene)
SLC39A3GeneProduct29985 (Entrez Gene)
SLC39A4GeneProduct55630 (Entrez Gene)
SMAD3GeneProduct4088 (Entrez Gene)
SMAD4GeneProduct4089 (Entrez Gene)
SPARCGeneProduct6678 (Entrez Gene)
SQSTM1GeneProduct8878 (Entrez Gene)
SRCGeneProduct6714 (Entrez Gene)
TGFB1GeneProduct7040 (Entrez Gene)
THBS1GeneProduct7057 (Entrez Gene)
TNFSF15GeneProduct9966 (Entrez Gene)
TP53GeneProduct7157 (Entrez Gene)
ULK1GeneProduct8408 (Entrez Gene) ATG1
UVRAGGeneProduct7405 (Entrez Gene)
VTNGeneProduct7448 (Entrez Gene)
bcl-xLGeneProduct
pkb?GeneProduct

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP615"
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